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https://www.readbyqxmd.com/read/29147666/sympathetic-denervation-accelerates-wound-contraction-but-inhibits-reepithelialization-and-pericyte-proliferation-in-diabetic-mice
#1
Zhifang Zheng, Yu Wan, Yishu Liu, Yu Yang, Jianbing Tang, Wenhua Huang, Biao Cheng
Previous studies focused on the effects of sympathetic denervation with 6-hydroxydopamine (6-OHDA) on nondiabetic wounds, but the effects of 6-OHDA on diabetic wounds have not been previously reported. In this study, treated mice received intraperitoneal 6-OHDA, and control mice received intraperitoneal injections of normal saline. Full-thickness wounds were established on the backs of mice. The wounds were sectioned (four mice per group) for analysis at 2, 5, 7, 10, 14, 17, and 21 days after injury. The wound areas in the control group were larger than those in the treatment group...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29121832/how-a-simple-ankle-sprain-turned-into-neuropathic-pain-complex-reflex-sympathetic-dystrophy-versus-erythromelalgia
#2
Ann Regina Lurati
A 36-year-old woman sustained a Grade 2 ankle sprain at work. Two days after the injury, the ankle and foot became red and she complained of "intense burning pain." First diagnosed with complex reflex sympathetic dystrophy, the employee was prescribed medications that provided some pain relief; a subsequent temporary nerve block provided additional relief. However, the symptoms returned and she was treated unsuccessfully with surgical sympathectomy. The employee was referred to a neurologist and diagnosed with primary erythromelalgia, a rare pain disorder that can be mistaken as complex reflex sympathetic dystrophy...
November 1, 2017: Workplace Health & Safety
https://www.readbyqxmd.com/read/29104105/bilateral-superior-cervical-ganglionectomy-attenuates-the-progression-of-%C3%AE-aminopropionitrile-induced-aortic-dissection-in-rats
#3
Huan Liu, Xiangxiang Zheng, Linfei Zhang, Xuechao Yang, Yongfeng Shao, Shijiang Zhang
AIMS: Aortic dissection (AD) represents one of the most common aortic emergencies with high incidence of morbidity and mortality. Clinical studies have shown that the increased excitability of the sympathetic nerve may be associated with the formation of AD. In this study, we examined the effects of bilateral superior cervical sympathectomy (SCGx) on the progression of β-aminopropionitrile (BAPN)-induced AD in rats. MAIN METHODS: Sprague-Dawley rats were randomly divided into three groups, including BAPN, BAPN+SCGx and control groups...
November 2, 2017: Life Sciences
https://www.readbyqxmd.com/read/29049566/evaluation-of-patients-who-underwent-resympathectomy-for-treatment-of-primary-hyperhidrosis
#4
José Ribas Milanez de Campos, Lucas Lembrança, Juliana Maria Fukuda, Paulo Kauffman, Marcelo Passos Teivelis, Pedro Puech-Leão, Nelson Wolosker
OBJECTIVES: Video thoracoscopic sympathectomy is the recommended surgical treatment for primary hyperhidrosis and has a high success rate. Despite this high success rate, some patients are unresponsive and eventually need a resympathectomy. Few studies have previously analysed exclusively the results of these resympathectomies in patients with primary hyperhidrosis. None of the studies have objectively evaluated the degree of response to surgery or the improvement in quality of life after resympathectomies...
November 1, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29019534/evaluation-of-the-quality-of-life-of-patients-with-primary-hyperhidrosis-submitted-to-videothoracoscopic-sympathectomy
#5
Sandoval Lage da Silva, Rossano Kepler Alvim Fiorelli, Maria Ribeiro Santos Morard
OBJECTIVE: to evaluate the quality of life of patients undergoing video-assisted thoracoscopy for primary hyperhidrosis. METHODS: we evaluated the patients who underwent thoracoscopic sympathectomy to treat primary hyperhidrosis by the team of thoracic surgery at the University Hospital Gaffrée and Guinle - UNIRIO between July 2004 and August 2013. It was applied a questionnaire about quality of life related to hyperhidrosis since preoperative period until one year after the surgery...
July 2017: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/28985838/t3-versus-t4-thoracoscopic-sympathectomy-for-palmar-hyperhidrosis-a-meta-analysis-and-systematic-review
#6
REVIEW
Wenxiong Zhang, Yiping Wei, Han Jiang, Jianjun Xu, Dongliang Yu
BACKGROUND: Palmar hyperhidrosis (PH) is a benign sympathetic disorder that can adversely affect the quality of life of patients. Thoracic sympathectomy (TS) at the T3 or T4 level has been used to treat PH. We aimed to determine the optimal denervation level for TS by comparing the efficacy of T3 TS versus T4 TS in PH patients. METHODS: We searched the PubMed, Ovid MEDLINE, EMBASE, Web of Science, ScienceDirect, the Cochrane Library, Scopus, and Google Scholar databases for studies comparing T3 versus T4 TS for PH...
October 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28977371/resolution-of-generalized-compensatory-hyperhidrosis-related-to-sympathectomy-after-t2-sympatholysis
#7
Malcolm Brock, Christos S Georgiades
Compensatory hyperhidrosis (CH) is common after sympathectomy, and most treatments are ineffective. We present a 36-year-old man whose CH was effectively treated with percutaneous sympatholysis. The patient's axillary-palmar hyperhidrosis had been treated with T3-4 sympathetic ligation. The patient developed CH involving the head, face, back, torso and feet and was referred for computed tomography-guided percutaneous T2 sympatholysis for craniofacial symptoms, after which the patient experienced resolution of CH (complete face/neck/feet and partial back/torso), despite the treated level being above the previous ligation...
July 21, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28962894/sympathetic-innervation-is-essential-for-metabolic-homeostasis-and-pancreatic-beta-cell-function-in-adult-rats
#8
REVIEW
Kelly V Prates, Júlio C de Oliveira, Ananda Malta, Camila C I Matiusso, Rosiane A Miranda, Tatiane A Ribeiro, Flávio A Francisco, Claudinéia C S Franco, Veridiana M Moreira, Vander S Alves, Rosana Torrezan, Paulo C F Mathias, Luiz F Barella
Obesity is associated with an imbalance in the activity of the autonomic nervous system (ANS), specifically in the organs involved in energy metabolism. The pancreatic islets are richly innervated by the ANS, which tunes the insulin release due to changes in energy demand. Therefore, changes in the sympathetic input that reach the pancreas can lead to metabolic dysfunctions. To evaluate the role of the sympathetic ends that innervate the pancreas, 60-day-old male Wistar rats were subjected to sympathectomy (SYM) or were sham-operated (SO)...
September 26, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28960445/vascular-branches-from-cutaneous-nerve-of-the-forearm-and-hand-application-to-better-understanding-raynaud-s-disease
#9
K Umemoto, M Ohmichi, Y Ohmichi, T Yakura, N Hammer, D Mizuno, M Naito, T Nakano
INTRODUCTION: Cutaneous nerves have branches called vascular branches (VBs) that reach arteries. VBs are thought to be involved in arterial constriction, and this is the rationale for periarterial sympathectomy as a treatment option for Raynaud's disease. However, the branching patterns and distribution areas of the VBs remain largely unclear. The aim of the present study was to investigate the anatomical structures of the VBs of the cutaneous nerves. MATERIALS AND METHODS: Forty hands and forearms were examined to assess the branching patterns and distribution areas of the VBs of the superficial branch of the radial nerve (SBRN), the lateral antebrachial cutaneous nerve (LACN), the medial antebrachial cutaneous nerve (MACN), and the palmar cutaneous branch of the ulnar nerve (PCUN)...
September 29, 2017: Clinical Anatomy
https://www.readbyqxmd.com/read/28931760/inflammation-oxidative-stress-and-glial-cell-activation-characterize-stellate-ganglia-from-humans-with-electrical-storm
#10
Olujimi A Ajijola, Donald B Hoover, Thomas M Simerly, T Christopher Brown, Jane Yanagawa, Reshma M Biniwale, Jay M Lee, Ali Sadeghi, Negar Khanlou, Jeffrey L Ardell, Kalyanam Shivkumar
BACKGROUND: Neuronal remodeling in human heart disease is not well understood. METHODS: Stellate ganglia from patients with cardiomyopathy (CMY) and refractory ventricular arrhythmias undergoing cardiac sympathetic denervation (n = 8), and from organ donors with normal hearts (n = 8) collected at the time of organ procurement were compared. Clinical data on all subjects were reviewed. Electron microscopy (EM), histologic, and immunohistochemical assessments of neurotransmitter profiles, glial activation and distribution, and lipofuscin deposition, a marker of oxidative stress, were quantified...
September 21, 2017: JCI Insight
https://www.readbyqxmd.com/read/28929251/risk-reduction-of-long-term-major-adverse-cardiovascular-events-after-endoscopic-thoracic-sympathectomy-in-palmar-hyperhidrosis
#11
Chun-An Cheng, Chun-Gu Cheng, Hsin Chu, Hung-Che Lin, Chi-Hsiang Chung, Hung-Wen Chiu, Wu-Chien Chien
PURPOSE: Palmar hyperhidrosis (PH) is excessive sweating of the palms resulting from sympathetic overactivity, and patients who undergo endoscopic thoracic sympathectomy (ETS) show reduced cardiac demand after 1 year and improved cerebral perfusion within 2-4 weeks. However, the long-term risks of major adverse cardiovascular events (MACE) following ETS remain unclear. METHODS: We searched the Longitudinal National Health Insurance Database in Taiwan and identified PH patients (International Classification of Disease, Ninth Revision, Clinical Modification diagnostic code 708...
December 2017: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/28920529/surgical-interventions-for-organ-and-limb-ischemia-associated-with-primary-and-secondary-antiphospholipid-antibody-syndrome-with-arterial-involvement
#12
Carlos A Hinojosa, Javier E Anaya-Ayala, Karla Bermudez-Serrato, Ramón García-Alva, Hugo Laparra-Escareno, Adriana Torres-Machorro, Rene Lizola
OBJECTIVE: The association of antiphospholipid antibody syndrome (APS) and hypercoagulability is well known. Arterial compromise leading to ischemia of organs and/or limbs in patients with APS is uncommon, frequently unrecognized, and rarely described. We evaluated our institutional experience. METHODS: Retrospective review was conducted. From August 2007 to September 2016, 807 patients with diagnosis of APS were managed in our Institution. Patients with primary and secondary APS who required interventions were examined...
November 2017: Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28917558/cardiac-sympathectomy-for-the-management-of-ventricular-arrhythmias-refractory-to-catheter-ablation
#13
Travis Richardson, Ricardo Lugo, Pablo Saavedra, George Crossley, Walter Clair, Sharon Shen, Juan Carlos Estrada, Jay Montgomery, M Benjamin Shoemaker, Christopher Ellis, Gregory F Michaud, Eric Lambright, Arvindh N Kanagasundram
BACKGROUND: Catheter ablation is now a mainstay of therapy for ventricular arrhythmias (VAs). However, there are scenarios where either physiological or anatomical factors make ablation less likely to be successful. OBJECTIVE: The purpose of this study was to demonstrate that cardiac sympathetic denervation (CSD) may be an alternate therapy for patients with difficult-to-ablate VAs. METHODS: We identified all patients referred for CSD at a single center for indications other than long QT syndrome and catecholaminergic polymorphic ventricular tachycardia who had failed catheter ablation...
September 14, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28871176/interleukin-17a-is-involved-in-mechanical-hyperalgesia-but-not-in-the-severity-of-murine-antigen-induced-arthritis
#14
Matthias Ebbinghaus, Gabriel Natura, Gisela Segond von Banchet, Susanne Hensellek, Martin Böttcher, Birgit Hoffmann, Firas Subhi Salah, Mieczyslaw Gajda, Thomas Kamradt, Hans-Georg Schaible
Interleukin-17A (IL-17A) is considered an important pro-inflammatory cytokine but its importance in joint diseases such as rheumatoid arthritis (RA) is unclear. It has also been reported that IL-17A may induce pain but it is unclear whether pro-inflammatory and pro-nociceptive effects are linked. Here we studied in wild type (WT) and IL-17A knockout (IL-17AKO) mice inflammation and hyperalgesia in antigen-induced arthritis (AIA). We found that the severity and time course of AIA were indistinguishable in WT and IL-17AKO mice...
September 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28862182/does-endoscopic-thoracic-sympathectomy-through-clipping-procedure-have-early-effects-on-electrocardiographic-parameters
#15
Fatih Candas, Zafer Isilak, Akin Yildizhan, Omer Uz, Murat Yalcin, Rauf Gorur, Turgut Isitmangil
BACKGROUND & OBJECTIVES: Hyperhidrosis is a pathologic condition of excessive sweating in amounts greater than physiologic needs. Endoscopic thoracic sympathectomy (ETS) is a globally accepted treatment modality for primary palmar and axillary hyperhidrosis. ETS also has distinctive effects on the heart, circulatory and respiratory systems. In this study early effects of ETS on electrocardiographic (ECG) parameters of hyperhidrosis patients were evaluated. METHODS: Twelve-lead ECGs were performed on 72 patients who were free from cardiovascular, metabolic, neurological and pulmonary diseases and underwent planned ETS because of hyperhidrosis, before and after the procedure within the first 24 h...
April 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28860792/endothelial-dysfunction-in-patients-with-buerger-disease
#16
Kimihiro Igari, Toshifumi Kudo, Takahiro Toyofuku, Yoshinori Inoue
We evaluated the endothelial function of patients with Buerger disease using peripheral arterial tonometry test, and examined the factors that are significantly correlated with the endothelial dysfunction in these patients. We performed the peripheral arterial tonometry test in 22 patients with Buerger disease. We recorded the patients' characteristics, including ankle brachial pressure index and reactive hyperemia index, which reflect the endothelial dysfunction. We divided the patients with Buerger disease into the conservative treatment and lumbar sympathectomy group...
2017: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/28852403/recovery-of-sympathetic-nerve-function-after-lumbar-sympathectomy-is-slower-in-the-hind-limbs-than-in-the-torso
#17
Zhi-Fang Zheng, Yi-Shu Liu, Xuan Min, Jian-Bing Tang, Hong-Wei Liu, Biao Cheng
Local sympathetic denervation by surgical sympathectomy is used in the treatment of lower limb ulcers and ischemia, but the restoration of cutaneous sympathetic nerve functions is less clear. This study aims to explore the recovery of cutaneous sympathetic functions after bilateral L2-4 sympathectomy. The skin temperature of the left feet, using a point monitoring thermometer, increased intraoperatively after sympathectomy. The cytoplasm of sympathetic neurons contained tyrosine hydroxylase and dopamine β-hydroxylase, visualized by immunofluorescence, indicated the accuracy of sympathectomy...
July 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28833780/stellate-ganglion-blockade-for-the-treatment-of-refractory-ventricular-arrhythmias-a-systematic-review-and-meta-analysis
#18
Marat Fudim, Richard Boortz-Marx, Arun Ganesh, Nathan H Waldron, Yawar J Qadri, Chetan B Patel, Carmelo A Milano, Albert Y Sun, Joseph P Mathew, Jonathan P Piccini
INTRODUCTION: Treatment refractory ventricular arrhythmias (VAs) are often driven and exacerbated by heightened sympathetic tone. We aim to conduct a systematic review and meta-analysis of published studies of a temporary percutaneous stellate ganglion block (SGB) on VA burden and defibrillation episodes in patients with treatment refractory VAs. METHODS: Relevant studies from January 1960 through May 2017 were identified in PubMed and Google Scholar. We performed a patient-level analysis using Student's t-test to compare outcomes before and after SGB...
August 18, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28811905/surgical-sympathectomy-for-buerger-s-disease
#19
REVIEW
Daniel G Cacione, Daniel H Moreno, Luis Cu Nakano, José Cc Baptista-Silva
Buerger's disease is characterized by recurring progressive inflammation and occlusions in small and medium arteries and veins of the limbs. Its cause is unknown, but it is most common in young men with a history of tobacco use. It is responsible for ischemic ulcers and extreme pain in the hands and feet. In many cases, notably in patients with the most severe presentations, there is no possibility of improving the condition with surgery (limb revascularisation), and therefore, alternative therapies (e.g. sympathectomy) is used...
August 2017: JRSM Open
https://www.readbyqxmd.com/read/28759961/lumbar-sympathectomy-regulates-vascular-cell-turnover-in-rat-hindfoot-plantar-skin
#20
Zhifang Zheng, Yu Wan, Yishu Liu, Lulu Zhu, Jianbing Tang, Wenhua Huang, Biao Cheng
BACKGROUND: Sympathetic denervation and impaired angiogenesis cause skin diseases. However, the relationship between the sympathetic nervous system and vascular cell turnover in normal skin remains unclear. OBJECTIVE: To determine the effects of sympathetic denervation on vascular cell turnover in normal skin. METHODS: Rats underwent bilateral L2-4 sympathetic trunk resection (sympathectomy group) or sham operation (control). Hindfoot plantar skin was analyzed 2 weeks and 3 months postoperatively...
July 25, 2017: Clinical Hemorheology and Microcirculation
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