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Preterm infants follow neurological

Elizabeth V Asztalos, Paige T Church, Patricia Riley, Carlos Fajardo, Prakesh S Shah
Objective This study aims to examine the association between the absence of neonatal comorbidities, as well as the presence of indicators of clinical progress with good neurodevelopmental (ND) outcomes, at 18 months corrected age in a national cohort of preterm infants of < 29 weeks' gestation. Design Study subjects included preterm infants (< 29 weeks' gestation) born in 2010 and 2011. Univariate analyses were conducted and regression estimates were calculated for variables where odds of a good ND outcome, composite scores ≥ 100 in three domains (cognitive, language, and motor) in the Bayley Scales of Infant and Toddler Development, 3rd ed...
September 2, 2016: American Journal of Perinatology
David Ley, Olga Romantsik, Suvi Vallius, Kristbjörg Sveinsdóttir, Snjolaug Sveinsdóttir, Alex A Agyemang, Maria Baumgarten, Matthias Mörgelin, Nataliya Lutay, Matteo Bruschettini, Bo Holmqvist, Magnus Gram
Severe cerebral intraventricular hemorrhage (IVH) in preterm infants continues to be a major clinical problem, occurring in about 15-20% of very preterm infants. In contrast to other brain lesions the incidence of IVH has not been reduced over the last decade, but actually slightly increased. Currently over 50% of surviving infants develop post-hemorrhagic ventricular dilatation and about 35% develop severe neurological impairment, mainly cerebral palsy and intellectual disability. To date there is no therapy available to prevent infants from developing either hydrocephalus or serious neurological disability...
2016: Frontiers in Physiology
Maja Petkovic, Lauriane Rat-Fischer, Jacqueline Fagard
Preterm born children without neurological impairments have been shown to present some visual-manual coordination deficits, more or less depending on their tonicity and the degree of prematurity. In this paper, we compare the development of tool use in 15-23-month-old preterm infants born after 33-36 weeks of gestation without neurological complications with that of full-term infants according to corrected age. Understanding the affordance of a tool is an important cognitive milestone in early sensorimotor period...
2016: Frontiers in Psychology
Gabriella Di Rosa, Tiziana Cavallaro, Angela Alibrandi, Lucia Marseglia, Marco Lamberti, Elisa Giaimo, Antonio Nicotera, Maria Bonsignore, Antonella Gagliano
BACKGROUND: Developmental milestones are useful signposts developed to assess the pace and the trajectory of maturation occurring during specific time-windows called critical periods. The predictive role of their clinical assessment in premature infants is challenging, however, it actually represents an easy and reliable tool at follow-up. AIM AND STUDY DESIGN: Relying on a milestone-based neurological examination, we aimed to detect the interdependence between time of achievement of each milestone with long-term neuropsychological and neurodevelopmental outcomes...
October 2016: Early Human Development
Isabelle Guellec, Alexandre Lapillonne, Stephane Marret, Jean-Charles Picaud, Delphine Mitanchez, Marie-Laure Charkaluk, Jeanne Fresson, Catherine Arnaud, Cyril Flamand, Gilles Cambonie, Monique Kaminski, Jean-Christophe Roze, Pierre-Yves Ancel
OBJECTIVE: To determine whether extrauterine growth is associated with neurologic outcomes and if this association varies by prenatal growth profile. STUDY DESIGN: For 1493 preterms from the EPIPAGE (Étude Épidémiologique sur les Petits Âges Gestationnels [Epidemiological Study on Small Gestational Ages]) cohort, appropriate for gestational-age (AGA) was defined by birth weight >-2 SD and small for gestational-age (SGA) by birth weight ≤-2 SD. Extra-uterine growth was defined by weight gain or loss between birth and 6 months by z-score change...
August 2016: Journal of Pediatrics
Jingang Li, Tamara Yawno, Amy Sutherland, Jan Loose, Ilias Nitsos, Robert Bischof, Margie Castillo-Melendez, Courtney A McDonald, Flora Y Wong, Graham Jenkin, Suzanne L Miller
Infants born very preterm are at high risk for neurological deficits including cerebral palsy. In this study we assessed the neuroprotective effects of umbilical cord blood cells (UCBCs) and optimal administration timing in a fetal sheep model of preterm brain injury. 50 million allogeneic UCBCs were intravenously administered to fetal sheep (0.7 gestation) at 12h or 5d after acute hypoxia-ischemia (HI) induced by umbilical cord occlusion. The fetal brains were collected at 10d after HI. HI (n=7) was associated with reduced number of oligodendrocytes (Olig2+) and myelin density (CNPase+), and increased density of activated microglia (Iba-1+) in cerebral white matter compared to control fetuses (P<0...
September 2016: Experimental Neurology
Julie Morin, Thuy Mai Luu, Rosanne Superstein, Luis H Ospina, Francine Lefebvre, Marie-Noëlle Simard, Vibhuti Shah, Prakesh S Shah, Edmond N Kelly
BACKGROUND AND OBJECTIVE: Bevacizumab intravitreal injection, a vascular endothelial growth factor inhibitor, is used to treat retinopathy of prematurity (ROP). However, concerns have been raised regarding its systemic absorption and effect on developing tissues including brain. This study compared neurodevelopment at 18 months' corrected age in preterm infants of <29 weeks' gestation treated with bevacizumab versus laser ablation. METHODS: Data from the Canadian Neonatal Network and the Canadian Neonatal Follow-Up Network databases were retrospectively reviewed...
April 2016: Pediatrics
Ilaria Orsenigo, Simona Serveli, Angela Cicconetti, Roberta Da Rin Della Mora
UNLABELLED: Theme: Cross-cultural nursing. INTRODUCTION: Preterm infants have to acquire neurological skills to begin breast or bottle feeding. The literature review suggested the need of a tool to assess the readiness of preterm infants for the transition from tube to oral feeding. Currently, there is not such a tool in the Italian context. AIM: To perform the cross-cultural validation of POFRAS from English to Italian. METHOD: We followed international guidelines to design and conduct the process (forward translations, synthesis, pilot test to assess the comprehensibility of the contents, back translations, synthesis)...
May 9, 2016: Nursing Children and Young People
Jin Young Bae, Hyun Hwa Cha, Won Joon Seong
BACKGROUND: A severely deformed vertebra is a matter of concern, particularly when it develops before 24 weeks of gestation, which may lead to compromised pulmonary function and neurological development. CASE: A 39-year-old, nulliparous woman presented at 19 weeks of gestation. Her uterus was snowman shaped due to uterine synechiae, and the fetus was confined in the upper section, where amniotic fluid was scanty. The fetal spine was flexed at the upper thoracic level at an angle greater than 90°, with the head flexed and touching the right shoulder throughout pregnancy...
March 2016: Journal of Reproductive Medicine
Mehmet Ramoğlu, Sultan Kavuncuoğlu, Esin Aldemir, Coşkun Yarar, Zeynep Eras
AIM: To compare perinatal, neonatal characteristics and neurodevelopmental prognosis of preterm infants born after in vitro fertilization (IVF) and spontaneous multiple pregnancies, and to evaluate the factors affecting the neurodevelopmental outcome at 24-36 months. METHODS: A total of 125 preterm infants, 65 from spontaneous and 60 from IVF multiple pregnancies were evaluated in terms of neurodevelopmental outcome at the age of 24-36 months. The mean maternal age, chronic maternal disease, birth weight, gestational week, gender, APGAR score, neonatal intensive care unit admission, presence of congenital anomalies, referral to follow-ups, rehospitalization and socioeconomic levels were investigated...
April 16, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
Monika Lachowska, Krzysztof Lachowski, Barbara Królak-Olejnik
INTRODUCTION: Percutaneously inserted central venous catheters (epicutaneo-cava-catheter - ECC) are widely used in neonatal intensive care, facilitating the parenteral nutrition and the treatment of critically ill newborns. This invasive procedure is regarded as safe and associated with low complication rate. Possible life-threatening complications may result from malpositioning of ECC. Paraspinal misplacement of ECC is one of the most serious complications. CASE PRESENTATION: The authors report a case of misplacement of ECC inserted via left saphenous vein for intravenous feeding...
2016: Journal of Vascular Access
Melek Akar, Zeynep Eras, Mehmet Yekta Oncel, Sema Arayici, Nilufer Guzoglu, Fuat Emre Canpolat, Nurdan Uras, Serife Suna Oguz
OBJECTIVE: The aim of the study was to evaluate the neurodevelopment outcomes of very low birth weight (VLBW) preterm infants supplemented with oral probiotics for the prevention of necrotizing enterocolitis (NEC). METHODS: A prospective follow-up study was performed in a cohort of VLBW preterm infants enrolled in a single center randomized controlled clinical trial to evaluate the efficacy of oral probiotics for the prevention of NEC. Cognitive and neuromotor developments were assessed by using the Bayley scales of infant development II...
May 5, 2016: Journal of Maternal-fetal & Neonatal Medicine
Federica Accordino, Sara Consonni, Tiziana Fedeli, Gaia Kullman, Francesca Moltrasio, Alessandro Ghidini, Anna Locatelli
OBJECTIVE: Gestational age (GA) at delivery and spontaneous prematurity are independent risk factors for cerebral palsy (CP). The aim of this study is to investigate perinatal risk factors for CP in spontaneous preterm delivery. METHODS: A retrospective cohort study of all single pregnancies complicated by spontaneous preterm labor (PTL) or PPROM with delivery at <34 weeks from January 2006 to December 2012 was performed. We compared demographic, obstetric, neonatal, and placental histology variables in cases of spontaneous preterm birth in reference to the development of CP...
December 2016: Journal of Maternal-fetal & Neonatal Medicine
M E Redshaw, M E Harvey
BACKGROUND: The study is part of a larger research programme on neonatal brain imaging in the trial element of which parents were randomised to receive prognostic information based upon either magnetic resonance imaging (MRI) or ultrasound findings (ePrime study). The aim of this study was to investigate the strategies used by clinicians in communicating with parents following imaging at term age of the brain of preterm infants born before 33 weeks gestation, focusing on explanations and information-giving about prognosis  METHOD: Audio recordings of discussions between parents and clinicians were made following MRI and ultrasound assessment...
2016: BMC Pediatrics
Elie Azria, Gilles Kayem, Bruno Langer, Laetitia Marchand-Martin, Stephane Marret, Jeanne Fresson, Véronique Pierrat, Catherine Arnaud, François Goffinet, Monique Kaminski, Pierre-Yves Ancel
OBJECTIVE: To determine whether breech presentation is an independent risk factor for neonatal morbidity, mortality, or long-term neurologic morbidity in very preterm infants. DESIGN: Prospective population-based cohort. POPULATION: Singletons infants without congenital malformations born from 27 to 32 completed weeks of gestation enrolled in France in 1997 in the EPIPAGE cohort. METHODS: The neonatal and long-term follow-up outcomes of preterm infants were compared between those in breech presentation and those in vertex presentation...
2016: PloS One
Laura Bourgoin, Cecile Cipierre, Quentin Hauet, Helene Basset, Veronique Gournay, Jean-Christophe Rozé, Cyril Flamant, Geraldine Gascoin
BACKGROUND: Patent ductus arteriosus (PDA) is a condition frequently found in very preterm infants, and its treatment remains a subject of debate. Furthermore, there are only a few studies available that have examined the impact of these treatments on the neurological outcome of the patient. OBJECTIVE: To evaluate the neurodevelopmental outcome of PDA treatment on preterm infants born between 24+0 and 28+6 weeks of gestation. METHODS: We conducted an observational multicentric cohort study (LIFT Cohort)...
2016: Neonatology
Pier P Bassareo, Andrea R Marras, Lucia Cugusi, Angela M Zedda, Giuseppe Mercuro
The survival percentage of infants born preterm has risen steadily worldwide thanks to the giant steps forward made in the field of perinatal (the period immediately after birth) and neonatal (the first 4 weeks of birth following delivery) medicine. However, prematurity at birth and consequent low birth weight still represent the major causes of neonatal morbidity and mortality. Infants born preterm are at high risk of developing neurological, ophthalmological, and gastrointestinal complications as well. Furthermore, extensive more recent epidemiological findings have demonstrated an increase in risk factors and a higher mortality rate due to cardiovascular causes in patients born preterm and/or with intrauterine growth restriction...
May 2016: Journal of Cardiovascular Medicine
Jessie R Maxwell, Jesse L Denson, Nancy E Joste, Shenandoah Robinson, Lauren L Jantzie
INTRODUCTION: Preterm birth is a major cause of infant morbidity and long-term disability, and is associated with numerous central nervous system (CNS) deficits. Infants exposed to intrauterine inflammation, specifically chorioamnionitis, are at risk for very early preterm birth and neurological complications including cerebral palsy, epilepsy, and behavioral and cognitive deficits. However, placenta-brain axis abnormalities and their relationship to subsequent permanent CNS injury remain poorly defined...
December 2015: Placenta
Eisha A Christian, Edward F Melamed, Edwin Peck, Mark D Krieger, J Gordon McComb
OBJECT Posthemorrhagic hydrocephalus (PHH) in the preterm infant remains a major neurological complication of prematurity. The authors first described insertion of a specially designed low-profile subcutaneous ventricular catheter reservoir for temporary management of hydrocephalus in 1983. This report presents the follow-up experience with the surgical management of PHH in this population and describes outcomes both in infants who were stable for permanent shunt insertion and those initially temporized with a ventricular reservoir (VR) prior to permanent ventriculoperitoneal (VP)/ventriculoatrial (VA) shunt placement...
March 2016: Journal of Neurosurgery. Pediatrics
Wai-Tim Jim, Nan-Chang Chiu, Che-Sheng Ho, Chyong-Hsin Shu, Jui-Hsing Chang, Han-Yang Hung, Hsin-An Kao, Hung-Yang Chang, Chun-Chih Peng, Bey-Hwa Yui, Chih-Pin Chuu
Approximately 15% of preterm infants may develop postnatal cytomegalovirus (CMV) infection from seropositive mothers via breast milk and are at risk for neurological sequelae in childhood. The aims of this study were to assess the effects and outcomes on growth, neurodevelopmental status, and hearing in very low birth weight (VLBW) premature infants with postnatal CMV infection via breast milk at the corrected age of 12 and 24 months.The prospective follow-up study population comprised all living preterm children (n = 55) with a birth weight ≤1500 g and gestational age of ≤35 weeks, who had been participated in our "postnatal CMV infection via breast milk" studies in 2000 and 2009, respectively...
October 2015: Medicine (Baltimore)
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