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Preterm infants follow neurological

Nathalie Charpak, Rejean Tessier, Juan G Ruiz, Jose Tiberio Hernandez, Felipe Uriza, Julieta Villegas, Line Nadeau, Catherine Mercier, Francoise Maheu, Jorge Marin, Darwin Cortes, Juan Miguel Gallego, Dario Maldonado
BACKGROUND AND OBJECTIVES: Kangaroo mother care (KMC) is a multifaceted intervention for preterm and low birth weight infants and their parents. Short- and mid-term benefits of KMC on survival, neurodevelopment, breastfeeding, and the quality of mother-infant bonding were documented in a randomized controlled trial (RCT) conducted in Colombia from 1993 to 1996. The aim of the present study was to evaluate the persistence of these results in young adulthood. METHODS: From 2012 to 2014, a total of 494 (69%) of the 716 participants of the original RCT known to be alive were identified; 441 (62% of the participants in the original RCT) were re-enrolled, and results for the 264 participants weighing ≤1800 g at birth were analyzed...
January 2017: Pediatrics
Barthelemy Tosello, Meriem Zahed, Floriane Guimond, Karine Baumstarck, Alice Faure, Fabrice Michel, Olivier Claris, Jerome Massardier, Catherine Gire, Thierry Merrot
Introduction Quantify quality of life (QoL) outcomes in gastroschisis children is little assessed. The primary objective was to describe the long-term outcome of newborns with gastroschisis treated in three tertiary care hospitals of France in terms of neurodevelopment and QoL. Materials and Methods The study reported was a cross-sectional, descriptive multicentric retrospective study assessing the outcome of newborns with gastroschisis, born between January 1, 2009, and December 31, 2014, treated at two large and French level III neonatal intensive care units...
December 8, 2016: European Journal of Pediatric Surgery
Sun Young Seo, Gyu Hong Shim, Myoung Jae Chey, Su Jeong You
PURPOSE: This study aimed to identify prognostic factors of neurological outcomes, including developmental delay, cerebral palsy and epilepsy in late-preterm and term infants with perinatal asphyxia. METHODS: All late-preterm and term infants with perinatal asphyxia or hypoxic-ischemic insults who admitted the neonatal intensive care unit of Inje University Sanggye Paik Hospital between 2006 and 2014 and were followed up for at least 2 years were included in this retrospective study...
November 2016: Korean Journal of Pediatrics
Krishna Revanna Gopagondanahalli, Jingang Li, Michael C Fahey, Rod W Hunt, Graham Jenkin, Suzanne L Miller, Atul Malhotra
Hypoxic-ischemic encephalopathy (HIE) is a recognizable and defined clinical syndrome in term infants that results from a severe or prolonged hypoxic-ischemic episode before or during birth. However, in the preterm infant, defining hypoxic-ischemic injury (HII), its clinical course, monitoring, and outcomes remains complex. Few studies examine preterm HIE, and these are heterogeneous, with variable inclusion criteria and outcomes reported. We examine the available evidence that implies that the incidence of hypoxic-ischemic insult in preterm infants is probably higher than recognized and follows a more complex clinical course, with higher rates of adverse neurological outcomes, compared to term infants...
2016: Frontiers in Pediatrics
Elizabeth V Asztalos, Paige T Church, Patricia Riley, Carlos Fajardo, Prakesh S Shah
Objective This study aims to examine the association between the absence of neonatal comorbidities, as well as the presence of indicators of clinical progress with good neurodevelopmental (ND) outcomes, at 18 months corrected age in a national cohort of preterm infants of < 29 weeks' gestation. Design Study subjects included preterm infants (< 29 weeks' gestation) born in 2010 and 2011. Univariate analyses were conducted and regression estimates were calculated for variables where odds of a good ND outcome, composite scores ≥ 100 in three domains (cognitive, language, and motor) in the Bayley Scales of Infant and Toddler Development, 3rd ed...
September 2, 2016: American Journal of Perinatology
David Ley, Olga Romantsik, Suvi Vallius, Kristbjörg Sveinsdóttir, Snjolaug Sveinsdóttir, Alex A Agyemang, Maria Baumgarten, Matthias Mörgelin, Nataliya Lutay, Matteo Bruschettini, Bo Holmqvist, Magnus Gram
Severe cerebral intraventricular hemorrhage (IVH) in preterm infants continues to be a major clinical problem, occurring in about 15-20% of very preterm infants. In contrast to other brain lesions the incidence of IVH has not been reduced over the last decade, but actually slightly increased. Currently over 50% of surviving infants develop post-hemorrhagic ventricular dilatation and about 35% develop severe neurological impairment, mainly cerebral palsy and intellectual disability. To date there is no therapy available to prevent infants from developing either hydrocephalus or serious neurological disability...
2016: Frontiers in Physiology
Maja Petkovic, Lauriane Rat-Fischer, Jacqueline Fagard
Preterm born children without neurological impairments have been shown to present some visual-manual coordination deficits, more or less depending on their tonicity and the degree of prematurity. In this paper, we compare the development of tool use in 15-23-month-old preterm infants born after 33-36 weeks of gestation without neurological complications with that of full-term infants according to corrected age. Understanding the affordance of a tool is an important cognitive milestone in early sensorimotor period...
2016: Frontiers in Psychology
Gabriella Di Rosa, Tiziana Cavallaro, Angela Alibrandi, Lucia Marseglia, Marco Lamberti, Elisa Giaimo, Antonio Nicotera, Maria Bonsignore, Antonella Gagliano
BACKGROUND: Developmental milestones are useful signposts developed to assess the pace and the trajectory of maturation occurring during specific time-windows called critical periods. The predictive role of their clinical assessment in premature infants is challenging, however, it actually represents an easy and reliable tool at follow-up. AIM AND STUDY DESIGN: Relying on a milestone-based neurological examination, we aimed to detect the interdependence between time of achievement of each milestone with long-term neuropsychological and neurodevelopmental outcomes...
October 2016: Early Human Development
Isabelle Guellec, Alexandre Lapillonne, Stephane Marret, Jean-Charles Picaud, Delphine Mitanchez, Marie-Laure Charkaluk, Jeanne Fresson, Catherine Arnaud, Cyril Flamand, Gilles Cambonie, Monique Kaminski, Jean-Christophe Roze, Pierre-Yves Ancel
OBJECTIVE: To determine whether extrauterine growth is associated with neurologic outcomes and if this association varies by prenatal growth profile. STUDY DESIGN: For 1493 preterms from the EPIPAGE (Étude Épidémiologique sur les Petits Âges Gestationnels [Epidemiological Study on Small Gestational Ages]) cohort, appropriate for gestational-age (AGA) was defined by birth weight >-2 SD and small for gestational-age (SGA) by birth weight ≤-2 SD. Extra-uterine growth was defined by weight gain or loss between birth and 6 months by z-score change...
August 2016: Journal of Pediatrics
Jingang Li, Tamara Yawno, Amy Sutherland, Jan Loose, Ilias Nitsos, Robert Bischof, Margie Castillo-Melendez, Courtney A McDonald, Flora Y Wong, Graham Jenkin, Suzanne L Miller
Infants born very preterm are at high risk for neurological deficits including cerebral palsy. In this study we assessed the neuroprotective effects of umbilical cord blood cells (UCBCs) and optimal administration timing in a fetal sheep model of preterm brain injury. 50 million allogeneic UCBCs were intravenously administered to fetal sheep (0.7 gestation) at 12h or 5d after acute hypoxia-ischemia (HI) induced by umbilical cord occlusion. The fetal brains were collected at 10d after HI. HI (n=7) was associated with reduced number of oligodendrocytes (Olig2+) and myelin density (CNPase+), and increased density of activated microglia (Iba-1+) in cerebral white matter compared to control fetuses (P<0...
September 2016: Experimental Neurology
Julie Morin, Thuy Mai Luu, Rosanne Superstein, Luis H Ospina, Francine Lefebvre, Marie-Noëlle Simard, Vibhuti Shah, Prakesh S Shah, Edmond N Kelly
BACKGROUND AND OBJECTIVE: Bevacizumab intravitreal injection, a vascular endothelial growth factor inhibitor, is used to treat retinopathy of prematurity (ROP). However, concerns have been raised regarding its systemic absorption and effect on developing tissues including brain. This study compared neurodevelopment at 18 months' corrected age in preterm infants of <29 weeks' gestation treated with bevacizumab versus laser ablation. METHODS: Data from the Canadian Neonatal Network and the Canadian Neonatal Follow-Up Network databases were retrospectively reviewed...
April 2016: Pediatrics
Ilaria Orsenigo, Simona Serveli, Angela Cicconetti, Roberta Da Rin Della Mora
UNLABELLED: Theme: Cross-cultural nursing. INTRODUCTION: Preterm infants have to acquire neurological skills to begin breast or bottle feeding. The literature review suggested the need of a tool to assess the readiness of preterm infants for the transition from tube to oral feeding. Currently, there is not such a tool in the Italian context. AIM: To perform the cross-cultural validation of POFRAS from English to Italian. METHOD: We followed international guidelines to design and conduct the process (forward translations, synthesis, pilot test to assess the comprehensibility of the contents, back translations, synthesis)...
May 9, 2016: Nursing Children and Young People
Jin Young Bae, Hyun Hwa Cha, Won Joon Seong
BACKGROUND: A severely deformed vertebra is a matter of concern, particularly when it develops before 24 weeks of gestation, which may lead to compromised pulmonary function and neurological development. CASE: A 39-year-old, nulliparous woman presented at 19 weeks of gestation. Her uterus was snowman shaped due to uterine synechiae, and the fetus was confined in the upper section, where amniotic fluid was scanty. The fetal spine was flexed at the upper thoracic level at an angle greater than 90°, with the head flexed and touching the right shoulder throughout pregnancy...
March 2016: Journal of Reproductive Medicine
Mehmet Ramoğlu, Sultan Kavuncuoğlu, Esin Aldemir, Coşkun Yarar, Zeynep Eras
BACKGROUND: The aim of this study was to compare perinatal, neonatal characteristics and neurodevelopmental prognosis of preterm infants born after in vitro fertilization (IVF) and spontaneous multiple pregnancy, and to evaluate the factors affecting neurodevelopmental outcome at 24-36 months. METHODS: A total of 125 preterm infants, 65 from spontaneous and 60 from IVF multiple pregnancy were evaluated in terms of neurodevelopmental outcome at the age of 24-36 months...
December 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
Monika Lachowska, Krzysztof Lachowski, Barbara Królak-Olejnik
INTRODUCTION: Percutaneously inserted central venous catheters (epicutaneo-cava-catheter - ECC) are widely used in neonatal intensive care, facilitating the parenteral nutrition and the treatment of critically ill newborns. This invasive procedure is regarded as safe and associated with low complication rate. Possible life-threatening complications may result from malpositioning of ECC. Paraspinal misplacement of ECC is one of the most serious complications. CASE PRESENTATION: The authors report a case of misplacement of ECC inserted via left saphenous vein for intravenous feeding...
July 12, 2016: Journal of Vascular Access
Melek Akar, Zeynep Eras, Mehmet Yekta Oncel, Sema Arayici, Nilufer Guzoglu, Fuat Emre Canpolat, Nurdan Uras, Serife Suna Oguz
OBJECTIVE: The aim of the study was to evaluate the neurodevelopment outcomes of very low birth weight (VLBW) preterm infants supplemented with oral probiotics for the prevention of necrotizing enterocolitis (NEC). METHODS: A prospective follow-up study was performed in a cohort of VLBW preterm infants enrolled in a single center randomized controlled clinical trial to evaluate the efficacy of oral probiotics for the prevention of NEC. Cognitive and neuromotor developments were assessed by using the Bayley scales of infant development II...
February 2017: Journal of Maternal-fetal & Neonatal Medicine
Federica Accordino, Sara Consonni, Tiziana Fedeli, Gaia Kullman, Francesca Moltrasio, Alessandro Ghidini, Anna Locatelli
OBJECTIVE: Gestational age (GA) at delivery and spontaneous prematurity are independent risk factors for cerebral palsy (CP). The aim of this study is to investigate perinatal risk factors for CP in spontaneous preterm delivery. METHODS: A retrospective cohort study of all single pregnancies complicated by spontaneous preterm labor (PTL) or PPROM with delivery at <34 weeks from January 2006 to December 2012 was performed. We compared demographic, obstetric, neonatal, and placental histology variables in cases of spontaneous preterm birth in reference to the development of CP...
December 2016: Journal of Maternal-fetal & Neonatal Medicine
M E Redshaw, M E Harvey
BACKGROUND: The study is part of a larger research programme on neonatal brain imaging in the trial element of which parents were randomised to receive prognostic information based upon either magnetic resonance imaging (MRI) or ultrasound findings (ePrime study). The aim of this study was to investigate the strategies used by clinicians in communicating with parents following imaging at term age of the brain of preterm infants born before 33 weeks gestation, focusing on explanations and information-giving about prognosis  METHOD: Audio recordings of discussions between parents and clinicians were made following MRI and ultrasound assessment...
February 11, 2016: BMC Pediatrics
Elie Azria, Gilles Kayem, Bruno Langer, Laetitia Marchand-Martin, Stephane Marret, Jeanne Fresson, Véronique Pierrat, Catherine Arnaud, François Goffinet, Monique Kaminski, Pierre-Yves Ancel
OBJECTIVE: To determine whether breech presentation is an independent risk factor for neonatal morbidity, mortality, or long-term neurologic morbidity in very preterm infants. DESIGN: Prospective population-based cohort. POPULATION: Singletons infants without congenital malformations born from 27 to 32 completed weeks of gestation enrolled in France in 1997 in the EPIPAGE cohort. METHODS: The neonatal and long-term follow-up outcomes of preterm infants were compared between those in breech presentation and those in vertex presentation...
2016: PloS One
Laura Bourgoin, Cecile Cipierre, Quentin Hauet, Helene Basset, Veronique Gournay, Jean-Christophe Rozé, Cyril Flamant, Geraldine Gascoin
BACKGROUND: Patent ductus arteriosus (PDA) is a condition frequently found in very preterm infants, and its treatment remains a subject of debate. Furthermore, there are only a few studies available that have examined the impact of these treatments on the neurological outcome of the patient. OBJECTIVE: To evaluate the neurodevelopmental outcome of PDA treatment on preterm infants born between 24+0 and 28+6 weeks of gestation. METHODS: We conducted an observational multicentric cohort study (LIFT Cohort)...
2016: Neonatology
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