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https://www.readbyqxmd.com/read/29763893/patterns-of-infancy-growth-and-metabolic-hormonal-profile-are-different-in-very-low-birth-weight-preterm-infants-born-small-for-gestational-age-compared-to-those-born-appropriate-for-gestational-age
#1
María Isabel Hernandez, Katherine Rossel, Veronica Peña, Mirna Garcia, Gabriel Cavada, Alejandra Avila, German Iñiguez, Verónica Mericq
BACKGROUND/AIMS: An increased preterm birth survival rate is associated with long-term neurological and metabolic risks; thus, our aim was to evaluate whether early patterns of infancy anthropometry and metabolic hormonal profile differ in preterm infants born small for gestational age (SGA) or appropriate for gestational age (AGA) from birth to 36 months of corrected age (CA). METHODS: We recruited 110 very-low-birth-weight (VLBW) preterm infants (AGA = 60 and SGA = 50) with a mean birth weight of -2...
May 15, 2018: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/29740187/do-preterm-infants-with-a-birth-weight-%C3%A2-1250-g-born-to-single-parent-families-have-poorer-neurodevelopmental-outcomes-at-age-3-than-those-born-to-two-parent-families
#2
Abhay Lodha, Jahan Lakhani, Krystyna Ediger, Selphee Tang, Arijit Lodha, Vardhil Gandhi, Dianne Creighton
OBJECTIVE: Investigate neurodevelopmental outcomes at 3 years corrected age in infants with a birth weight ≤1250 g born to single parents. STUDY DESIGN: Infants born between 1995 and 2010 with a birth weight ≤1250 g were considered eligible. Primary outcome was neurodevelopmental impairment; considered present if a child had any of the following: cerebral palsy, cognitive delay, visual impairment, or deafness/neurosensory hearing impairment. Univariate and multivariate analyses were performed...
May 8, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29726792/early-surgical-management-and-long-term-surgical-outcome-for-intraventricular-hemorrhage-related-posthemorrhagic-hydrocephalus-in-shunt-treated-premature-infants
#3
Hans Christoph Bock, Jacqueline Feldmann, Hans Christoph Ludwig
OBJECTIVE Perinatal intraventricular hemorrhage (IVH) in premature neonates may lead to severe neurological disability and lifelong treatment requirement for consecutive posthemorrhagic hydrocephalus (PHHC). Early CSF diversion as a temporizing measure, or a permanent ventriculoperitoneal shunt (VPS), is the treatment of choice. Preterm neonates are not only at high risk for different perinatal but also for treatment-related complications. The authors reviewed their institutional neurosurgical management for preterm neonates with IVH-related PHHC and evaluated shunt-related surgical outcome for this particular hydrocephalus etiology after completion of a defined follow-up period of 5 years after initial shunt insertion...
May 4, 2018: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29700828/therapeutic-potential-to-reduce-brain-injury-in-growth-restricted-newborns
#4
Julie A Wixey, Kirat K Chand, Lily Pham, Paul B Colditz, S Tracey Bjorkman
Brain injury in intrauterine growth restricted (IUGR) infants is a major contributing factor to morbidity and mortality worldwide. Adverse outcomes range from mild learning difficulties, to attention difficulties, neurobehavioral issues, cerebral palsy, epilepsy, and other cognitive and psychiatric disorders. While the use of medication to ameliorate neurological deficits in IUGR neonates have been identified as warranting urgent research for several years, few trials have been reported. This review summarises clinical trials focusing on brain protection in the IUGR newborn as well as therapeutic interventions trialled in animal models of IUGR...
April 27, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29694990/respiratory-instability-and-hypoxemia-episodes-in-preterm-infants
#5
Eduardo Bancalari, Nelson Claure
Oxygenation instability is a very common problem in the premature infant that manifests as intermittent hypoxemia episodes (HEs). These are particularly frequent in premature infants who are on mechanical ventilation beyond the first weeks after birth. However, they can also occur in spontaneously breathing infants. Some of these episodes are due to central apnea, but in ventilated infants, they are frequently due to contractions of the abdominal musculature that can splint the respiratory pump, resulting in periods of decreased lung volume and hypoventilation...
May 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29686862/tryptophan-metabolic-profile-in-term-and-preterm-breast-milk-implications-for-health
#6
Louise O'Rourke, Gerard Clarke, Aoife Nolan, Claire Watkins, Timothy G Dinan, Catherine Stanton, R Paul Ross, Cornelius Anthony Ryan
Breast milk is the only source of the essential amino acid tryptophan (TRP) in breast-fed infants. Low levels of TRP could have implications for infant neurodevelopment. The objectives of the present study were to compare the relationship of TRP and its neuroactive pathway metabolites kynurenine (Kyn) and kynurenic acid (KynA) in preterm and term expressed breast milk (EBM) in the first 14 d following birth, and the relationship of TRP metabolism to maternal stress and immune status. A total of twenty-four mothers were recruited from Cork University Maternity Hospital: twelve term (>38 weeks) and twelve preterm (<35 weeks)...
2018: Journal of Nutritional Science
https://www.readbyqxmd.com/read/29678206/biliverdin-reductase-a-attenuated-gmh-induced-inflammatory-response-in-the-spleen-by-inhibiting-toll-like-receptor-4-through-enos-no-pathway
#7
Yiting Zhang, Yan Ding, Tai Lu, Yixin Zhang, Ningbo Xu, Devin W McBride, Jiping Tang, John H Zhang
BACKGROUND: Germinal matrix hemorrhage (GMH) is a common neurologic event with high morbidity and mortality in preterm infants. Spleen has been reported to play a critical role in inflammatory responses by regulating peripheral immune cells which contributes to secondary brain injury. METHODS: The current study investigated the mechanistic role of biliverdin reductase-A (BLVRA) in the splenic response and brain damage in neonates following a collagenase GMH model...
April 20, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29673373/chorioamnionitis-neuroinflammation-and-injury-timing-is-key-in-the-preterm-ovine-fetus
#8
Ruth Gussenhoven, Rob J J Westerlaken, Daan R M G Ophelders, Alan H Jobe, Matthew W Kemp, Suhas G Kallapur, Luc J Zimmermann, Per T Sangild, Stanislava Pankratova, Pierre Gressens, Boris W Kramer, Bobbi Fleiss, Tim G A M Wolfs
BACKGROUND: Antenatal infection (i.e., chorioamnionitis) is an important risk factor for adverse neurodevelopmental outcomes after preterm birth. Destructive and developmental disturbances of the white matter are hallmarks of preterm brain injury. Understanding the temporal effects of antenatal infection in relation to the onset of neurological injury is crucial for the development of neurotherapeutics for preterm infants. However, these dynamics remain unstudied. METHODS: Time-mated ewes were intra-amniotically injected with lipopolysaccharide at 5, 12, or 24 h or 2, 4, 8, or 15 days before preterm delivery at 125 days gestational age (term ~ 150 days)...
April 19, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29666163/neurodevelopmental-impairment-among-extremely-preterm-infants-in-the-neonatal-research-network
#9
Ira Adams-Chapman, Roy J Heyne, Sara B DeMauro, Andrea F Duncan, Susan R Hintz, Athina Pappas, Betty R Vohr, Scott A McDonald, Abhik Das, Jamie E Newman, Rosemary D Higgins
OBJECTIVES: Evaluate the spectrum of neurodevelopmental outcome in a contemporary cohort of extremely preterm infants. We hypothesize that the rate of severe neurodevelopmental impairment (NDI) decreases over time. METHODS: Retrospective analysis of neurodevelopmental outcome of preterm infants ≤27 weeks' gestational age (GA) from a Neonatal Research Network center that completed neurodevelopmental follow-up assessments between April 1, 2011, and January 1, 2015...
April 17, 2018: Pediatrics
https://www.readbyqxmd.com/read/29628409/prospective-follow-up-of-a-cohort-of-preterm-infants-33-wg-receiving-ketamine-for-tracheal-intubation-in-the-delivery-room-neurological-outcome-at-1-and-2-years
#10
C Elalouf, A-G Le Moing, C Fontaine, A Leke, G Kongolo, J Gondry, P Tourneux
OBJECTIVE: Although ketamine analgesia is effective in reducing pain and facilitating the tracheal intubation of newborns in the delivery room, no data on the neurological effects of this treatment are available. This study compared the neurodevelopmental outcomes at 2 years of age in a cohort of preterm newborns having received ketamine prior to tracheal intubation at birth (the ketamine group) and in a control group. METHODS: We included newborns delivered at less than 33 weeks gestational age (WGA) having undergone tracheal intubation at birth...
April 5, 2018: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/29624206/paracetamol-acetaminophen-for-patent-ductus-arteriosus-in-preterm-or-low-birth-weight-infants
#11
REVIEW
Arne Ohlsson, Prakeshkumar S Shah
BACKGROUND: In preterm newborns, the ductus arteriosus frequently fails to close and the infants require medical or surgical closure of the patent ductus arteriosus (PDA). A PDA can be treated surgically; or medically with one of two prostaglandin inhibitors, indomethacin or ibuprofen. Case reports suggest that paracetamol may be an alternative for the closure of a PDA. An association between prenatal or postnatal exposure to paracetamol and later development of autism or autism spectrum disorder has been reported...
April 6, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29579059/cardiac-findings-in-infants-with-in-utero-exposure-to-zika-virus-a-cross-sectional-study
#12
Dulce H G Orofino, Sonia R L Passos, Raquel V C de Oliveira, Carla Verona B Farias, Maria de Fatima M P Leite, Sheila M Pone, Marcos V da S Pone, Helena A R Teixeira Mendes, Maria Elizabeth L Moreira, Karin Nielsen-Saines
BACKGROUND: Antenatal exposure to Zika virus (ZIKV) is related to severe neurological manifestations. A previous study in Brazil reported an increased incidence of non-severe congenital heart defects in infants with diagnosis of congenital Zika syndrome but without laboratory confirmation of ZIKV infection in the mother or infant. The objective of this study is to report echocardiographic (ECHO) findings in infants with laboratory confirmed antenatal exposure to ZIKV. METHODOLOGY: Cross sectional study of cardiologic assessments of infants born between November 2015 and January 2017 with confirmed vertical exposure to ZIKV in Rio de Janeiro, Brazil...
March 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29571948/neurological-outcome-at-6-and-12-months-corrected-age-in-hospitalised-late-preterm-infants-a-prospective-study
#13
Ilias Chatziioannidis, Maria Kyriakidou, Sotiria Exadaktylou, Evangelia Antoniou, Dimitrios Zafeiriou, Nikolaos Nikolaidis
Late preterm infants (34-0/7 to 36-6/7 weeks" gestation) account for 10-20% of NICU admissions and are at increased risk for morbidity and mortality. Although they are prone to developmental delays, reports on neurological outcome during the first 2 years of life are scarce. The aim of the study was to assess neurological/neuromotor outcome in high risk late preterm infants at 6 and 12 months corrected age and the change in neurological scores over time, and to identify factors associated with the neurological outcome...
March 6, 2018: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/29567656/cerebellar-growth-impairment-characterizes-school-aged-children-born-preterm-without-perinatal-brain-lesions
#14
K Pieterman, T J White, G E van den Bosch, W J Niessen, I K M Reiss, D Tibboel, F E Hoebeek, J Dudink
BACKGROUND AND PURPOSE: Infants born preterm are commonly diagnosed with structural brain lesions known to affect long-term neurodevelopment negatively. Yet, the effects of preterm birth on brain development in the absence of intracranial lesions remain to be studied in detail. In this study, we aim to quantify long term consequences of preterm birth on brain development in this specific group. MATERIALS AND METHODS: Neonatal cranial sonography and follow-up T1-weighted MR imaging and DTI were performed to evaluate whether the anatomic characteristics of the cerebrum and cerebellum in a cohort of school-aged children (6-12 years of age) were related to gestational age at birth in children free of brain lesions in the perinatal period...
March 22, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29484288/ventilation-strategies-during-neonatal-cardiopulmonary-resuscitation
#15
REVIEW
Nariae Baik, Megan O'Reilly, Caroline Fray, Sylvia van Os, Po-Yin Cheung, Georg M Schmölzer
Approximately, 10-20% of newborns require breathing assistance at birth, which remains the cornerstone of neonatal resuscitation. Fortunately, the need for chest compression (CC) or medications in the delivery room (DR) is rare. About 0.1% of term infants and up to 15% of preterm infants receive these interventions, this will result in approximately one million newborn deaths annually worldwide. In addition, CC or medications (epinephrine) are more frequent in the preterm population (~15%) due to birth asphyxia...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29467523/early-low-dose-hydrocortisone-is-the-neurodevelopment-affected
#16
Gaston Ofman, Marta Perez, Kathryn N Farrow
TYPE OF INVESTIGATION: Prognosis; exploratory secondary analysis of an interventional randomized controlled trial. QUESTION: In extremely preterm infant (<28 weeks), is early low-dose hydrocortisone compared to placebo associated with neurodevelopmental impairment at 2 years of age? METHODS: Patients: Surviving infants enrolled in the PREMILOC trial conducted in France between 2008 and 2014. INTERVENTION: Double-blind, multicenter, randomized, placebo-controlled trial of infants born between 24 0/7 weeks and 27 6/7 weeks of gestation and before 24 h of postnatal age, assigned to receive either placebo or low-dose hydrocortisone (0...
February 21, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29428154/neonatal-infection-in-children-with-cerebral-palsy-a-registry-based-cohort-study
#17
Anne-Sophie Smilga, Jarred Garfinkle, Pamela Ng, John Andersen, David Buckley, Darcy Fehlings, Adam Kirton, Ellen Wood, Esias van Rensburg, Michael Shevell, Maryam Oskoui
BACKGROUND: The goal of this study was to explore the association between neonatal infection and outcomes in children with cerebral palsy. METHODS: We conducted a retrospective cohort study using the Canadian CP Registry. Neonatal infection was defined as meeting one of the following criteria: (1) septicemia, (2) septic shock, or (3) administration of antibiotics for ≥10 days. Phenotypic profiles of children with cerebral palsy with and without an antecedent neonatal infection were compared...
March 2018: Pediatric Neurology
https://www.readbyqxmd.com/read/29400610/psychosocial-functioning-in-adolescents-results-according-to-amiel-tison-neurological-assessment-in-a-group-of-preterm-infants
#18
Jana Kodric, Breda Sustersic, Darja Paro-Panjan
OBJECTIVE: This prospective study investigated the relationship between Amiel-Tison neurological assessment (ATNA) in preterm children and their psychosocial functioning in adolescence. METHODS: From the initial group of 45 children regularly assessed by the ATNA from term until the age of 2 years, 27 participated in the follow-up at 13 years. RESULTS: Of the three groups categorized by neurological signs as normal, intermediate or abnormal, parents of adolescents with normal ATNA reported the lowest number of executive function problems (p = 0...
February 5, 2018: Developmental Neurorehabilitation
https://www.readbyqxmd.com/read/29381949/late-onset-transient-adrenal-insufficiency-in-preterm-twins-with-twin-to-twin-transfusion-syndrome-a-case-report
#19
Chin Yee Ho, Zong-Rong He, San-Nan Yang, Yung-Ning Yang
RATIONALE: Late-onset transient adrenal insufficiency with circulatory collapse is a rare condition that occurs in preterm infants. Although the incidence of late-onset transient adrenal insufficiency in preterm infants has been reported in Japan, reports from Western countries are lacking. In addition, no study has investigated the effect of twin-to-twin transfusion syndrome (TTTS) in monozygotic twins. PATIENT CONCERNS: A pair of extremely low birth weight twins presented with TTTS...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29316931/nutritional-adequacy-of-a-novel-human-milk-fortifier-from-donkey-milk-in-feeding-preterm-infants-study-protocol-of-a-randomized-controlled-clinical-trial
#20
Alessandra Coscia, Enrico Bertino, Paola Tonetto, Chiara Peila, Francesco Cresi, Sertac Arslanoglu, Guido E Moro, Elena Spada, Silvano Milani, Marzia Giribaldi, Sara Antoniazzi, Amedeo Conti, Laura Cavallarin
BACKGROUND: Fortification of human milk is a standard practice for feeding very low birth weight infants. However, preterm infants often still experience suboptimal growth and feeding intolerance. New fortification strategies and different commercially available fortifiers have been developed. Commercially available fortifiers are constituted by a blend of ingredients from different sources, including plant oils and bovine milk proteins, thus presenting remarkable differences in the quality of macronutrients with respect to human milk...
January 9, 2018: Nutrition Journal
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