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https://www.readbyqxmd.com/read/28938302/anesthesia-information-management-clinical-decision-support
#1
Robert E Freundlich, Jesse M Ehrenfeld
PURPOSE OF REVIEW: Perioperative informatics tools continue to be developed at a rapid pace and offer clinicians the potential to greatly enhance clinical decision making. The goal of this review is to bring the reader updates on perioperative information management and discuss future research directions in the field. RECENT FINDINGS: Clinical decision support tools become more timely, accurate, and, in some instances, have been shown to improve patient outcomes...
September 21, 2017: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/28832563/participation-in-interdisciplinary-meetings-on-genetic-diagnostics-ngs
#2
Tom Koole, Lotte van Burgsteden, Paulien Harms, Cleo C van Diemen, Irene M van Langen
Diagnostics using next generation sequencing (NGS) requires high-quality interdisciplinary collaboration. In order to gain insight into this crucial collaborative process, we made video recordings of a new multidisciplinary team at work in the clinical genetics department of the University Medical Centre Groningen. Conversation Analysis was used to investigate the ways in which the team members deal with the disciplinary boundaries between them. We found that the team established different 'participation frames' in which to discuss recurring topics...
October 2017: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/28699568/evaluation-of-the-informatician-perspective-determining-types-of-research-papers-preferred-by-clinicians
#3
Boshu Ru, Xiaoyan Wang, Lixia Yao
BACKGROUND: To deliver evidence-based medicine, clinicians often reference resources that are useful to their respective medical practices. Owing to their busy schedules, however, clinicians typically find it challenging to locate these relevant resources out of the rapidly growing number of journals and articles currently being published. The literature-recommender system may provide a possible solution to this issue if the individual needs of clinicians can be identified and applied...
July 5, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28682958/defining-the-primary-outcomes-and-justifying-secondary-outcomes-of-a-study-usually-the-fewer-the-better
#4
Thomas R Vetter, Edward J Mascha
One of the first steps in designing and conducting a research study is identifying the primary and any secondary study outcomes. In an experimental, quasi-experimental, or analytic observational research study, the primary study outcomes arise from and align directly with the primary study aim or objective. Likewise, any secondary study outcomes arise from and directly align with any secondary study aim or objective. One designated primary study outcome then forms the basis for and is incorporated literally into the stated hypothesis...
August 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28679874/find-your-passion-lead-with-purpose-a-health-informaticians-guide
#5
Mowafa Househ
Health Informatics is an ever evolving, changing and dynamic field that has become the disruptive innovation shaping the future of healthcare. Health informaticians face a number of challenges in the workplace such as gaining acceptance and recognition from other healthcare providers and overcoming the resistance of healthcare providers from using technology in clinical practice. Being a health informatician is not for the faint hearted, especially as resistance to the role of health informaticians continues from both healthcare providers and hospital administrators...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28573677/physical-properties-of-the-chromosomes-and-implications-for-development
#6
REVIEW
Takeshi Sugawara, Akatsuki Kimura
Remarkable progress has been made in understanding chromosome structures inside the cell nucleus. Recent advances in Hi-C technologies enable the detection of genome-wide chromatin interactions, providing insight into three-dimensional (3D) genome organization. Advancements in the spatial and temporal resolutions of imaging as well as in molecular biological techniques allow the tracking of specific chromosomal loci, improving our understanding of chromosome movements. From these data, we are beginning to understand how the intra-nuclear locations of chromatin loci and the 3D genome structure change during development and differentiation...
June 2, 2017: Development, Growth & Differentiation
https://www.readbyqxmd.com/read/28549446/-gnparser-a-powerful-parser-for-scientific-names-based-on-parsing-expression-grammar
#7
Dmitry Y Mozzherin, Alexander A Myltsev, David J Patterson
BACKGROUND: Scientific names in biology act as universal links. They allow us to cross-reference information about organisms globally. However variations in spelling of scientific names greatly diminish their ability to interconnect data. Such variations may include abbreviations, annotations, misspellings, etc. Authorship is a part of a scientific name and may also differ significantly. To match all possible variations of a name we need to divide them into their elements and classify each element according to its role...
May 26, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28480121/alchemy-a-web-2-0-real-time-quality-assurance-platform-for-human-immunodeficiency-virus-hepatitis-c-virus-and-bk-virus-quantitation-assays
#8
Emmanuel Agosto-Arroyo, Gina M Coshatt, Thomas S Winokur, Shuko Harada, Seung L Park
BACKGROUND: The molecular diagnostics laboratory faces the challenge of improving test turnaround time (TAT). Low and consistent TATs are of great clinical and regulatory importance, especially for molecular virology tests. Laboratory information systems (LISs) contain all the data elements necessary to do accurate quality assurance (QA) reporting of TAT and other measures, but these reports are in most cases still performed manually: a time-consuming and error-prone task. The aim of this study was to develop a web-based real-time QA platform that would automate QA reporting in the molecular diagnostics laboratory at our institution, and minimize the time expended in preparing these reports...
2017: Journal of Pathology Informatics
https://www.readbyqxmd.com/read/28379377/eliie-an-open-source-information-extraction-system-for-clinical-trial-eligibility-criteria
#9
Tian Kang, Shaodian Zhang, Youlan Tang, Gregory W Hruby, Alexander Rusanov, Noémie Elhadad, Chunhua Weng
Objective: To develop an open-source information extraction system called Eligibility Criteria Information Extraction (EliIE) for parsing and formalizing free-text clinical research eligibility criteria (EC) following Observational Medical Outcomes Partnership Common Data Model (OMOP CDM) version 5.0. Materials and Methods: EliIE parses EC in 4 steps: (1) clinical entity and attribute recognition, (2) negation detection, (3) relation extraction, and (4) concept normalization and output structuring...
November 1, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/28272648/on-teaching-international-courses-on-health-information-systems-lessons-learned-during-16-years-of-frank-van-swieten-lectures-on-strategic-information-management-in-health-information-systems
#10
Elske Ammenwerth, Petra Knaup, Alfred Winter, Axel W Bauer, Oliver J Bott, Matthias Gietzelt, Birger Haarbrandt, Werner O Hackl, Nils Hellrung, Gudrun Hübner-Bloder, Franziska Jahn, Monique W Jaspers, Ulrike Kutscha, Christoph Machan, Bianca Oppermann, Jochen Pilz, Jonas Schwartze, Christoph Seidel, Jan-Eric Slot, Stefan Smers, Katharina Spitalewsky, Nathalie Steckel, Alexander Strübing, Minne van der Haak, Reinhold Haux, Willem J Ter Burg
BACKGROUND: Health information systems (HIS) are one of the most important areas for biomedical and health informatics. In order to professionally deal with HIS well-educated informaticians are needed. Because of these reasons, in 2001 an international course has been established: The Frank - van Swieten Lectures on Strategic Information Management of Health Information Systems. OBJECTIVES: Reporting about the Frank - van Swieten Lectures and about our students' feedback on this course during the last 16 years...
March 8, 2017: Methods of Information in Medicine
https://www.readbyqxmd.com/read/28214562/leveraging-health-informatics-to-a-foster-smart-systems-response-to-health-disparities-and-health-equity-challenges
#11
Timothy Jay Carney, Amanda Y Kong
Informaticians are challenged to design health IT solutions for complex problems like health disparities but are only achieving mixed results in demonstrating a direct impact on health outcomes. This presentation of collective intelligence and the corresponding terms of smart health, knowledge ecosystem, enhanced health disparities informatics capacities, knowledge exchange, big-data, and situational awareness are means of demonstrating the complex challenges informatics professional face in trying to model, measure, and manage an intelligence and a smart systems response to health disparities...
February 15, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28106590/competency-recommendations-for-advancing-nursing-informatics-in-the-next-decade-international-survey-results
#12
Charlene Ronquillo, Maxim Topaz, Lisiane Pruinelli, Laura-Maria Peltonen, Raji Nibber
The IMIA-NIstudents' and emerging professionals' working group conducted a large international survey in 2015 regarding research trends in nursing informatics. The survey was translated into half-a-dozen languages and distributed through 18 international research collaborators' professional connections. The survey focused on the perspectives of nurse informaticians. A total of 272 participants responded to an open ended question concerning recommendations to advance nursing informatics. Five key areas for action were identified through our thematic content analysis: education, research, practice, visibility and collaboration...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/27900588/modeling-informatics-at-vertex-pharmaceuticals-incorporated-our-philosophy-for-sustained-impact
#13
Georgia McGaughey, W Patrick Walters
Molecular modelers and informaticians have the unique opportunity to integrate cross-functional data using a myriad of tools, methods and visuals to generate information. Using their drug discovery expertise, information is transformed to knowledge that impacts drug discovery. These insights are often times formulated locally and then applied more broadly, which influence the discovery of new medicines. This is particularly true in an organization where the members are exposed to projects throughout an organization, such as in the case of the global Modeling & Informatics group at Vertex Pharmaceuticals...
March 2017: Journal of Computer-aided Molecular Design
https://www.readbyqxmd.com/read/27805796/implementation-of-a-multicenter-performance-improvement-program-for-early-detection-and-treatment-of-severe-sepsis-in-general-medical-surgical-wards
#14
Christa Schorr, Andrew Odden, Laura Evans, Gabriel J Escobar, Snehal Gandhi, Sean Townsend, Mitchell Levy
Sepsis is a leading cause of in-hospital death, and evidence suggests a higher mortality in patients presenting with sepsis on the ward compared to those presenting to the emergency department. Ward patients who develop severe sepsis may have poor outcomes for a variety of reasons, including delayed diagnosis, lack of readily available staffing, and delayed treatment. We report on a multihospital quality improvement program for early detection and treatment of sepsis on general medical-surgical wards. We describe a multipronged approach to improve severe sepsis outcomes using the Institute for Healthcare Improvement's Plan-Do-Study-Act model...
November 2016: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/27632043/health-informaticians-drive-innovation-from-bench-to-bedside
#15
Doug Fridsma
No abstract text is available yet for this article.
September 2016: Biomedical Instrumentation & Technology
https://www.readbyqxmd.com/read/27547217/a-pedagogical-walkthrough-of-computational-modeling-and-simulation-of-wnt-signaling-pathway-using-static-causal-models-in-matlab
#16
Shriprakash Sinha
Simulation study in systems biology involving computational experiments dealing with Wnt signaling pathways abound in literature but often lack a pedagogical perspective that might ease the understanding of beginner students and researchers in transition, who intend to work on the modeling of the pathway. This paucity might happen due to restrictive business policies which enforce an unwanted embargo on the sharing of important scientific knowledge. A tutorial introduction to computational modeling of Wnt signaling pathway in a human colorectal cancer dataset using static Bayesian network models is provided...
December 2016: EURASIP Journal on Bioinformatics & Systems Biology
https://www.readbyqxmd.com/read/27506144/validating-the-extract-transform-load-process-used-to-populate-a-large-clinical-research-database
#17
Michael J Denney, Dustin M Long, Matthew G Armistead, Jamie L Anderson, Baqiyyah N Conway
BACKGROUND: Informaticians at any institution that are developing clinical research support infrastructure are tasked with populating research databases with data extracted and transformed from their institution's operational databases, such as electronic health records (EHRs). These data must be properly extracted from these source systems, transformed into a standard data structure, and then loaded into the data warehouse while maintaining the integrity of these data. We validated the correctness of the extract, load, and transform (ETL) process of the extracted data of West Virginia Clinical and Translational Science Institute's Integrated Data Repository, a clinical data warehouse that includes data extracted from two EHR systems...
October 2016: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/27492615/a-survey-of-the-job-profiles-of-biomedical-informatics-graduates
#18
Alessandra A Macedo, Evandro E S Ruiz, José A Baranauskas
BACKGROUND: In 2003, the University of São Paulo established the first Biomedical Informatics (BMI) undergraduate course in Brazil. Our mission is to provide undergraduate students with formal education on the fundamentals of BMI and its applied methods. This undergraduate course offers theoretical aspects, practical knowledge and scientifically oriented skills in the area of BMI, enab- ling students to contribute to research and methodical development in BMI. Course coordinators, professors and students frequently evaluate the BMI course and the curriculum to ensure that alumni receive quality higher education...
October 17, 2016: Methods of Information in Medicine
https://www.readbyqxmd.com/read/27441996/standardizing-terms-for-clinical-pharmacogenetic-test-results-consensus-terms-from-the-clinical-pharmacogenetics-implementation-consortium-cpic
#19
Kelly E Caudle, Henry M Dunnenberger, Robert R Freimuth, Josh F Peterson, Jonathan D Burlison, Michelle Whirl-Carrillo, Stuart A Scott, Heidi L Rehm, Marc S Williams, Teri E Klein, Mary V Relling, James M Hoffman
INTRODUCTION: Reporting and sharing pharmacogenetic test results across clinical laboratories and electronic health records is a crucial step toward the implementation of clinical pharmacogenetics, but allele function and phenotype terms are not standardized. Our goal was to develop terms that can be broadly applied to characterize pharmacogenetic allele function and inferred phenotypes. MATERIALS AND METHODS: Terms currently used by genetic testing laboratories and in the literature were identified...
February 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/27440303/front-matter
#20
(no author information available yet)
There's never been a more exciting time to be involved with health informatics. In the last few decades, health informaticians have established the knowledge base and practical expertise to facilitate the development of ever-more capable technical systems, increasing connectivity, expanding access and greater mobility of e-health and information management systems. We have seen the evolution from simple computer based records to systems that allow intra-organisational, national, even international communication and information exchange...
2016: Studies in Health Technology and Informatics
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