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https://www.readbyqxmd.com/read/27900588/modeling-informatics-at-vertex-pharmaceuticals-incorporated-our-philosophy-for-sustained-impact
#1
Georgia McGaughey, W Patrick Walters
Molecular modelers and informaticians have the unique opportunity to integrate cross-functional data using a myriad of tools, methods and visuals to generate information. Using their drug discovery expertise, information is transformed to knowledge that impacts drug discovery. These insights are often times formulated locally and then applied more broadly, which influence the discovery of new medicines. This is particularly true in an organization where the members are exposed to projects throughout an organization, such as in the case of the global Modeling & Informatics group at Vertex Pharmaceuticals...
November 29, 2016: Journal of Computer-aided Molecular Design
https://www.readbyqxmd.com/read/27805796/implementation-of-a-multicenter-performance-improvement-program-for-early-detection-and-treatment-of-severe-sepsis-in-general-medical-surgical-wards
#2
Christa Schorr, Andrew Odden, Laura Evans, Gabriel J Escobar, Snehal Gandhi, Sean Townsend, Mitchell Levy
Sepsis is a leading cause of in-hospital death, and evidence suggests a higher mortality in patients presenting with sepsis on the ward compared to those presenting to the emergency department. Ward patients who develop severe sepsis may have poor outcomes for a variety of reasons, including delayed diagnosis, lack of readily available staffing, and delayed treatment. We report on a multihospital quality improvement program for early detection and treatment of sepsis on general medical-surgical wards. We describe a multipronged approach to improve severe sepsis outcomes using the Institute for Healthcare Improvement's Plan-Do-Study-Act model...
November 2016: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/27632043/health-informaticians-drive-innovation-from-bench-to-bedside
#3
Doug Fridsma
No abstract text is available yet for this article.
September 2016: Biomedical Instrumentation & Technology
https://www.readbyqxmd.com/read/27547217/a-pedagogical-walkthrough-of-computational-modeling-and-simulation-of-wnt-signaling-pathway-using-static-causal-models-in-matlab
#4
Shriprakash Sinha
Simulation study in systems biology involving computational experiments dealing with Wnt signaling pathways abound in literature but often lack a pedagogical perspective that might ease the understanding of beginner students and researchers in transition, who intend to work on the modeling of the pathway. This paucity might happen due to restrictive business policies which enforce an unwanted embargo on the sharing of important scientific knowledge. A tutorial introduction to computational modeling of Wnt signaling pathway in a human colorectal cancer dataset using static Bayesian network models is provided...
December 2016: EURASIP Journal on Bioinformatics & Systems Biology
https://www.readbyqxmd.com/read/27506144/validating-the-extract-transform-load-process-used-to-populate-a-large-clinical-research-database
#5
Michael J Denney, Dustin M Long, Matthew G Armistead, Jamie L Anderson, Baqiyyah N Conway
BACKGROUND: Informaticians at any institution that are developing clinical research support infrastructure are tasked with populating research databases with data extracted and transformed from their institution's operational databases, such as electronic health records (EHRs). These data must be properly extracted from these source systems, transformed into a standard data structure, and then loaded into the data warehouse while maintaining the integrity of these data. We validated the correctness of the extract, load, and transform (ETL) process of the extracted data of West Virginia Clinical and Translational Science Institute's Integrated Data Repository, a clinical data warehouse that includes data extracted from two EHR systems...
October 2016: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/27492615/a-survey-of-the-job-profiles-of-biomedical-informatics-graduates
#6
Alessandra A Macedo, Evandro E S Ruiz, José A Baranauskas
BACKGROUND: In 2003, the University of São Paulo established the first Biomedical Informatics (BMI) undergraduate course in Brazil. Our mission is to provide undergraduate students with formal education on the fundamentals of BMI and its applied methods. This undergraduate course offers theoretical aspects, practical knowledge and scientifically oriented skills in the area of BMI, enab- ling students to contribute to research and methodical development in BMI. Course coordinators, professors and students frequently evaluate the BMI course and the curriculum to ensure that alumni receive quality higher education...
October 17, 2016: Methods of Information in Medicine
https://www.readbyqxmd.com/read/27441996/standardizing-terms-for-clinical-pharmacogenetic-test-results-consensus-terms-from-the-clinical-pharmacogenetics-implementation-consortium-cpic
#7
Kelly E Caudle, Henry M Dunnenberger, Robert R Freimuth, Josh F Peterson, Jonathan D Burlison, Michelle Whirl-Carrillo, Stuart A Scott, Heidi L Rehm, Marc S Williams, Teri E Klein, Mary V Relling, James M Hoffman
INTRODUCTION: Reporting and sharing pharmacogenetic test results across clinical laboratories and electronic health records is a crucial step toward the implementation of clinical pharmacogenetics, but allele function and phenotype terms are not standardized. Our goal was to develop terms that can be broadly applied to characterize pharmacogenetic allele function and inferred phenotypes. MATERIALS AND METHODS: Terms currently used by genetic testing laboratories and in the literature were identified...
July 21, 2016: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/27440303/front-matter
#8
(no author information available yet)
There's never been a more exciting time to be involved with health informatics. In the last few decades, health informaticians have established the knowledge base and practical expertise to facilitate the development of ever-more capable technical systems, increasing connectivity, expanding access and greater mobility of e-health and information management systems. We have seen the evolution from simple computer based records to systems that allow intra-organisational, national, even international communication and information exchange...
2016: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/27362589/clinical-information-systems-from-yesterday-to-tomorrow
#9
R M Gardner
OBJECTIVES: To review the history of clinical information systems over the past twenty-five years and project anticipated changes to those systems over the next twenty-five years. METHODS: Over 250 Medline references about clinical information systems, quality of patient care, and patient safety were reviewed. Books, Web resources, and the author's personal experience with developing the HELP system were also used. RESULTS: There have been dramatic improvements in the use and acceptance of clinical computing systems and Electronic Health Records (EHRs), especially in the United States...
2016: Yearbook of Medical Informatics
https://www.readbyqxmd.com/read/27332462/exploring-community-planning-thinking-as-a-model-for-use-case-development
#10
Marisa L Wilson, Paula M Procter
There are many vetted technical and semantic standards promulgated within the United States and the United Kingdom to operationalize eHealth interoperability in order to improve care outcomes, manage population health, and provide efficient information exchange between providers, services, patients and consumers. However, consideration must be given to the complex real world use cases in which the data and information will be exchanged between a wide variety of interested parties, including the consumer or patient...
2016: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/27332312/nursing-and-ehealth-are-we-preparing-our-future-nurses-as-automatons-or-informaticians
#11
Michelle Honey, Paula M Procter, Marisa L Wilson, Anne Moen, Grace T M Dal Sasso
The Education Working Group of IMIA NI present this thought provoking panel where the changing and challenging role of nursing will be explored within the information intensive eHealth arena. The session will be of interest to any nurse as the discussion will be driven by the objective of trying to understand how best to prepare nurses to be actively engaged in information and communication technology (ICT) developments that enhance care assessment, delivery, evaluation and audit. As a balance, the discussion will consider the increasing emergence of 'nursing by numbers' where risk assessment tools are used in an automatic way leaving little room for individual evidenced based care...
2016: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/27332309/accelerating-the-global-workforce-demand-for-nurse-informaticians-advanced-health-informatics-certification-ahic
#12
Cynthia Gadd, Connie W Delaney, Heimar de Fátima Marin, Karen Greenwood, Jeffrey J Williamson
Advances in professional recognition of nursing informatics vary by country but examples exist of training programs moving from curriculum-based education to competency based frameworks to produce highly skilled nursing informaticians. This panel will discuss a significant credentialing project in the United States that should further enhance professional recognition of highly skilled nurses matriculating from NI programs as well as nurses functioning in positions where informatics-induced transformation is occurring...
2016: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/27332198/the-nursing-informatician-s-role-in-mediating-technology-related-health-literacies
#13
Ramona Nelson, Heather D Carter-Templeton
The advent of computer based technology and the internet have not changed nurses' responsibility for patient education; but they are rapidly changing what we teach and how we teach. The challenge for nursing informaticians is to create innovative patient education models and applications with the goal of achieving literate, engaged, empowered and informed patients as well as preparing health professionals to maximize the advantages offered by digital media and other new technology based tools. This paper explores the interrelationship of basic literacy, health literacy and technology related literacies that provide the foundation for achieving these goals...
2016: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/27246337/mapping-protein-dna-interactions-using-chip-exo-and-illumina-based-sequencing
#14
Stefan J Barfeld, Ian G Mills
Chromatin immunoprecipitation (ChIP) provides a means of enriching DNA associated with transcription factors, histone modifications, and indeed any other proteins for which suitably characterized antibodies are available. Over the years, sequence detection has progressed from quantitative real-time PCR and Southern blotting to microarrays (ChIP-chip) and now high-throughput sequencing (ChIP-seq). This progression has vastly increased the sequence coverage and data volumes generated. This in turn has enabled informaticians to predict the identity of multi-protein complexes on DNA based on the overrepresentation of sequence motifs in DNA enriched by ChIP with a single antibody against a single protein...
2016: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27209183/analysis-of-the-process-of-representing-clinical-statements-for-decision-support-applications-a-comparison-of-openehr-archetypes-and-hl7-virtual-medical-record
#15
A González-Ferrer, M Peleg, M Marcos, J A Maldonado
Delivering patient-specific decision-support based on computer-interpretable guidelines (CIGs) requires mapping CIG clinical statements (data items, clinical recommendations) into patients' data. This is most effectively done via intermediate data schemas, which enable querying the data according to the semantics of a shared standard intermediate schema. This study aims to evaluate the use of HL7 virtual medical record (vMR) and openEHR archetypes as intermediate schemas for capturing clinical statements from CIGs that are mappable to electronic health records (EHRs) containing patient data and patient-specific recommendations...
July 2016: Journal of Medical Systems
https://www.readbyqxmd.com/read/27199189/silver-anniversary-25-editions-of-the-imia-yearbook
#16
C U Lehmann, M-C Jaulent, B Séroussi
OBJECTIVES: To provide an editorial introduction into the special 25th anniversary edition of the IMIA Yearbook of Medical Informatics with discussion of the significance of the Yearbook, past and current editorial teams, and a look into the future. METHODS: A brief overview of the 2016 anniversary edition of the Yearbook allows for a discussion of the significance and value of the Yearbook to the Biomedical Informatics community as well as a review of changes in Yearbook team and format over time...
2016: Yearbook of Medical Informatics
https://www.readbyqxmd.com/read/27198115/learning-training-and-teaching-of-health-informatics-and-its-evidence-for-informaticians-and-clinical-practice
#17
Evelyn Hovenga, Heather Grain
A globally agreed well structured framework representing the health informatics discipline's body of knowledge is yet to emerge. Considerable progress has been made towards describing this over the fifty or so years of the discipline's evolution. This contribution explains the need for such a structured body of knowledge from an educational and workforce capacity building perspective. Some examples of how education and training has been provided to date by a few key stakeholders/leaders are given and critical reviews of guideline and competency developments and their applications are presented...
2016: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/27195185/translation-in-data-mining-to-advance-personalized-medicine-for-health-equity
#18
Estela S Estape, Mary Helen Mays, Elizabeth A Sternke
Personalized medicine is the development of 'tailored' therapies that reflect traditional medical approaches, with the incorporation of the patient's unique genetic profile and the environmental basis of the disease. These individualized strategies encompass disease prevention, diagnosis, as well as treatment strategies. Today's healthcare workforce is faced with the availability of massive amounts of patient- and disease-related data. When mined effectively, these data will help produce more efficient and effective diagnoses and treatment, leading to better prognoses for patients at both the individual and population level...
January 2016: Intelligent Information Management
https://www.readbyqxmd.com/read/27185504/a-data-driven-concept-schema-for-defining-clinical-research-data-needs
#19
Gregory W Hruby, Julia Hoxha, Praveen Chandar Ravichandran, Eneida A Mendonça, David A Hanauer, Chunhua Weng
OBJECTIVES: The Patient, Intervention, Control/Comparison, and Outcome (PICO) framework is an effective technique for framing a clinical question. We aim to develop the counterpart of PICO to structure clinical research data needs. METHODS: We use a data-driven approach to abstracting key concepts representing clinical research data needs by adapting and extending an expert-derived framework originally developed for defining cancer research data needs. We annotated clinical trial eligibility criteria, EHR data request logs, and data queries to electronic health records (EHR), to extract and harmonize concept classes representing clinical research data needs...
July 2016: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/27156868/5-year-trends-in-qsar-and-its-machine-learning-methods
#20
Oleg T Devinyak, Roman B Lesyk
A bibliometric analysis of articles published in top molecular modeling and medicinal chemistry journals has been carried out in order to highlight recent trends of QSAR in general and trends of machine learning methods in particular. During 5-year span studied, the fraction of QSAR studies underwent a twofold decrease. Top journals of both categories became less likely to publish Multiple Linear Regression models and increased the presence of Random forest and Naïve Bayes methods. 3D-QSAR remains the most popular method of studying structure-activity relationships with a slight decrease of its presence in molecular modeling journals but a relative increase in medicinal chemistry...
May 9, 2016: Current Computer-aided Drug Design
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