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https://www.readbyqxmd.com/read/28646272/rhesus-cochlear-and-vestibular-functions-are-preserved-after-inner-ear-injection-of-saline-volume-sufficient-for-gene-therapy-delivery
#1
Chenkai Dai, Mohamed Lehar, Daniel Q Sun, Lani Swarthout Rvt, John P Carey, Tim MacLachlan, Doug Brough, Hinrich Staecker, Alexandra M Della Santina, Timothy E Hullar, Charles C Della Santina
Sensorineural losses of hearing and vestibular sensation due to hair cell dysfunction are among the most common disabilities. Recent preclinical research demonstrates that treatment of the inner ear with a variety of compounds, including gene therapy agents, may elicit regeneration and/or repair of hair cells in animals exposed to ototoxic medications or other insults to the inner ear. Delivery of gene therapy may also offer a means for treatment of hereditary hearing loss. However, injection of a fluid volume sufficient to deliver an adequate dose of a pharmacologic agent could, in theory, cause inner ear trauma that compromises functional outcome...
June 23, 2017: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/28465323/13-series-resolvins-mediate-the-leukocyte-platelet-actions-of-atorvastatin-and-pravastatin-in-inflammatory-arthritis
#2
Mary E Walker, Patricia R Souza, Romain A Colas, Jesmond Dalli
Rheumatoid arthritis is an inflammatory condition characterized by overzealous inflammation that leads to joint damage and is associated with an increased incidence of cardiovascular disease. Statins are frontline therapeutics for patients with cardiovascular disease and exert beneficial actions in rheumatoid arthritis. The mechanism that mediates the beneficial actions of statins in rheumatoid arthritis remains of interest. In the present study, we found that the administration of 2 clinically relevant statins-atorvastatin (0...
May 2, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28407492/residual-vein-thrombosis-and-serial-d-dimer-for-the-long-term-management-of-patients-with-deep-venous-thrombosis
#3
Paolo Prandoni, Valentina Vedovetto, Maurizio Ciammaichella, Eugenio Bucherini, Sara Corradini, Iolanda Enea, Benilde Cosmi, Nicola Mumoli, Adriana Visonà, Giovanni Barillari, Carlo Bova, Roberto Quintavalla, Nello Zanatta, Simona Pedrini, Sabina Villalta, Giuseppe Camporese, Sofie Testa, Roberto Parisi, Cecilia Becattini, Stefano Cuppini, Vittorio Pengo, Gualtiero Palareti
BACKGROUND: The optimal long-term strategy for preventing recurrent venous thromboembolism (VTE) in patients with deep-vein thrombosis (DVT) is uncertain. METHODS: In 620 consecutive outpatients with a first proximal DVT who had completed at least three months of anticoagulation (unprovoked in 483, associated with minor risk factors in 137), the ultrasound presence of residual vein thrombosis (RVT) was assessed and defined as an incompressibility of at least 4mm...
June 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28400236/synthesis-antiplatelet-and-antithrombotic-activities-of-resveratrol-derivatives-with-no-donor-properties
#4
Luiz Antonio Dutra, Jéssica Frade O Guanaes, Nadine Johmann, Maria Elisa Lopes Pires, Chung Man Chin, Sisi Marcondes, Jean Leandro Dos Santos
Resveratrol (RVT) is a stilbene with a protective effect on the cardiovascular system; however, drawbacks including low bioavailability and fast metabolism limit its efficacy. In this work we described new resveratrol derivatives with nitric oxide (NO) release properties, ability to inhibit platelet aggregation and in vivo antithrombotic effect. Compounds (4a-f) were able to release NO in vitro, at levels ranging from 24.1% to 27.4%. All compounds (2a-f and 4a-f) have exhibited platelet aggregation inhibition using as agonists ADP, collagen and arachidonic acid...
April 4, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28393617/residual-vein-thrombosis-echogenicity-is-associated-to-the-risk-of-dvt-recurrence-a-cohort-study
#5
Bruna M Mazetto, Fernanda L A Orsi, Sandra A F Silveira, Luis F Bittar, Mariane M C Flores-Nascimento, Kiara C S Zapponi, Marina P Colella, Erich V de Paula, Joyce M Annichino-Bizzacchi
Although deep vein thrombosis (DVT) recurrence is a common late complication of the disease, there are few predictive markers to risk-stratify patients long-term after the thrombotic event. The accuracy of residual vein thrombosis (RVT) in this context is controversial, possibly due to a lack of a standardized methodology. The objective of the study was to evaluate the accuracy of RVT echogenicity as a predictive marker of late DVT recurrence. To evaluate the accuracy of RVT echogenicity as a predictive marker of late DVT recurrence...
January 1, 2017: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/28364690/recanalization-rate-in-patients-with-proximal-vein-thrombosis-treated-with-the-direct-oral-anticoagulants
#6
Paolo Prandoni, Walter Ageno, Nicola Mumoli, Nello Zanatta, Davide Imberti, Adriana Visonà, Maurizio Ciammaichella, Livio Simioni, Roberto Cappelli, Eugenio Bucherini, Marcello Di Nisio, Giampiero Avruscio, Giuseppe Camporese, Roberto Parisi, Stefano Cuppini, Giacomo Turatti, Franco Noventa, Lucia Sarolo
BACKGROUND: The recanalization rate in patients with deep venous thrombosis (DVT) of the legs treated with the direct oral anticoagulants (DOAC) is unknown. METHODS: In an Italian cohort, we investigated the rate of residual vein thrombosis (RVT) after three and/or six months in 352 patients with proximal DVT who had been treated with the DOACs as a stand-alone therapy or lead-in parenteral anticoagulants, and compared it to that recorded in a historical cohort of 1094 patients in which vitamin K antagonists (VKAs) had been employed...
March 27, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28110589/incidences-risk-factors-and-outcomes-of-neonatal-thromboembolism
#7
Nongnuch Sirachainan, Anchalee Limrungsikul, Ampaiwan Chuansumrit, Pracha Nuntnarumit, Lunliya Thampratankul, Somporn Wangruangsathit, Werasak Sasanakul, Praguywan Kadegasem
BACKGROUND: The incidences of thromboembolism (TE) in neonates were reported to be around 0.51 per 10,000 live births per year for overall TE and 24 per 10,000 NICU admissions per year. As the incidences of TE in children and adults are lower in Asian populations, the incidences, risk factors, and outcomes of neonatal TE may be different to those reports from other countries. OBJECTIVES: To determine the incidences, risk factors, and outcomes of neonatal TE in a tertiary care hospital in Thailand...
February 9, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27973353/impact-of-physiological-noise-correction-on-detecting-blood-oxygenation-level-dependent-contrast-in-the-breast
#8
Tess E Wallace, Roido Manavaki, Martin J Graves, Andrew J Patterson, Fiona J Gilbert
Physiological fluctuations are expected to be a dominant source of noise in blood oxygenation level-dependent (BOLD) magnetic resonance imaging (MRI) experiments to assess tumour oxygenation and angiogenesis. This work investigates the impact of various physiological noise regressors: retrospective image correction (RETROICOR), heart rate (HR) and respiratory volume per unit time (RVT), on signal variance and the detection of BOLD contrast in the breast in response to a modulated respiratory stimulus. BOLD MRI was performed at 3 T in ten volunteers at rest and during cycles of oxygen and carbogen gas breathing...
January 7, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/27914038/serotonin-5-ht6-receptor-antagonists-in-alzheimer-s-disease-therapeutic-rationale-and-current-development-status
#9
Hilda Ferrero, Maite Solas, Paul T Francis, Maria J Ramirez
Alzheimer's disease (AD) is the most common cause of dementia in elderly people. Because of the lack of effective treatments for this illness, research focused on identifying compounds that restore cognition and functional impairments in patients with AD is a very active field. Since its discovery in 1993, the serotonin 5-HT6 receptor has received increasing attention, and a growing number of studies supported 5-HT6 receptor antagonism as a target for improving cognitive dysfunction in AD. This article reviews the rationale behind investigations into the targeting of 5-HT6 receptors as a symptomatic treatment for cognitive and/or behavioral symptoms of AD...
December 3, 2016: CNS Drugs
https://www.readbyqxmd.com/read/27899900/fiber-type-specific-satellite-cell-content-in-cyclists-following-heavy-training-with-carbohydrate-and-carbohydrate-protein-supplementation
#10
Alec I McKenzie, Andrew C D'Lugos, Michael J Saunders, Keith D Gworek, Nicholas D Luden
The central purpose of this study was to evaluate the fiber type-specific satellite cell and myonuclear responses of endurance-trained cyclists to a block of intensified training, when supplementing with carbohydrate (CHO) vs. carbohydrate-protein (PRO). In a crossover design, endurance-trained cyclists (n = 8) performed two consecutive training periods, once supplementing with CHO (de facto "control" condition) and the other with PRO. Each training period consisted of 10 days of intensified cycle training (ICT-120% increase in average training duration) followed by 10 days of recovery (RVT-reduced volume training; 33% volume reduction vs...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27888650/closure-of-the-cervical-os-in-patients-after-fertility-preserving-treatment-for-early-cervical-cancer-results-of-a-prospective-observational-study
#11
Mandy Mangler, Malgorzata Lanowska, Anne Bartens, Aaron Schindler, Jens-Uwe Blohmer, Dorothee Speiser
INTRODUCTION: Up to 50% of the infants delivered after radical vaginal trachelectomy (RVT) are born prematurely. An effective strategy to reduce this number could be the closure of the cervical os (CCO). PATIENTS AND METHODS: Fifteen pregnant patients who had a RVT due to early cervical cancer were included in this prospective case control study. All patients were scheduled for CCO early in the second trimester. CCO was performed in 12 patients. Their data were compared to data from 125 pregnancies after a RVT without CCO...
November 26, 2016: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/27883351/-rivaroxaban-resistant-right-ventricular-thrombus-successfully-treated-with-vitamin-k-antagonist-in-a-patient-with-dilated-cardiomyopathy
#12
Waldemar Elikowski, Małgorzata Małek-Elikowska, Marek Słomczyński, Teresa Ganowicz-Kaatz, Andrzej Bolewski, Paweł Skrzywanek
Rivaroxaban, a selective inhibitor of active factor X belongs to the group of direct-acting oral anticoagulants (DOAC), more and more often replacing vitamin K antagonists (VKA) in venous thromboembolic disease and nonvalvular atrial fibrillation. Attempts are also being made to use DOAC to treat locally formed intracardiac thrombi, mainly in the left atrium and its appendage, in atrial fibrillation and in heart failure. Rarely diagnosed local right ventricular thrombus (RVT) may be a complication of dilated cardiomyopathy (DCM)...
November 25, 2016: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/27832957/the-physio-toolbox-for-modeling-physiological-noise-in-fmri-data
#13
Lars Kasper, Steffen Bollmann, Andreea O Diaconescu, Chloe Hutton, Jakob Heinzle, Sandra Iglesias, Tobias U Hauser, Miriam Sebold, Zina-Mary Manjaly, Klaas P Pruessmann, Klaas E Stephan
BACKGROUND: Physiological noise is one of the major confounds for fMRI. A common class of correction methods model noise from peripheral measures, such as ECGs or pneumatic belts. However, physiological noise correction has not emerged as a standard preprocessing step for fMRI data yet due to: (1) the varying data quality of physiological recordings, (2) non-standardized peripheral data formats and (3) the lack of full automatization of processing and modeling physiology, required for large-cohort studies...
January 30, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/27796697/characteristics-of-patients-diagnosed-with-renal-vein-thrombosis-and-glomerulopathy-a-case-series
#14
Oliver Ross, Andrew Pourmoussa, Michael Batech, John J Sim
BACKGROUND: Few contemporary studies have evaluated the clinical characteristics of patients with biopsy-proven glomerulopathy diagnosed with renal vein thrombosis (RVT). METHODS: Retrospective case series study within an integrated health system in a 12-year period (January 1, 2000 through December 31, 2011) investigating clinical characteristics of all adult patients who underwent native or transplant kidney biopsy and also had a diagnosis of RVT. Patient characteristics, diagnostic studies, and outcomes were evaluated...
February 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/27790518/adult-idiopathic-renal-vein-thrombosis-mimicking-acute-pyelonephritis
#15
Arpan Choudhary, Prasenjit Majee, Rupesh Gupta, Supriyo Basu, Ranjit Kumar Das
Renal Vein Thrombosis (RVT) is a rarely encountered condition. It occurs due to a hypercoagulable state in the body, caused by nephrotic syndrome and membranous nephropathy in the adults. Mode of presentation is variable. In chronic form, it may remain silent for a long time and presenting later with symptoms of pedal oedema, varicocele, proteinuria. In acute state, it manifests as flank pain, nausea or haematuria. We present a case of 25-year-old male, with left sided flank pain, haematuria and nausea for 4 days...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27775614/curcumin-shows-antiviral-properties-against-norovirus
#16
Minji Yang, GilJae Lee, Jiyeon Si, Sung-Joon Lee, Hyun Ju You, GwangPyo Ko
Phytochemicals provide environmentally friendly and relatively inexpensive natural products, which could potentially benefit public health by controlling human norovirus (HuNoV) infection. In this study, 18 different phytochemicals were evaluated for antiviral effects against norovirus using murine norovirus (MNV) as a model for norovirus biology. Among these phytochemicals, curcumin (CCM) was the most potent anti-noroviral phytochemical, followed by resveratrol (RVT). In a cell culture infection model, exposure to CCM or RVT for 3 days reduced infectivity of norovirus by 91% and 80%, respectively...
October 20, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27618091/supplemental-protein-during-heavy-cycling-training-and-recovery-impacts-skeletal-muscle-and-heart-rate-responses-but-not-performance
#17
RANDOMIZED CONTROLLED TRIAL
Andrew C D'Lugos, Nicholas D Luden, Justin M Faller, Jeremy D Akers, Alec I McKenzie, Michael J Saunders
The effects of protein supplementation on cycling performance, skeletal muscle function, and heart rate responses to exercise were examined following intensified (ICT) and reduced-volume training (RVT). Seven cyclists performed consecutive periods of normal training (NT), ICT (10 days; average training duration 220% of NT), and RVT (10 days; training duration 66% of NT). In a crossover design, subjects consumed supplemental carbohydrate (CHO) or an equal amount of carbohydrate with added protein (CP) during and following each exercise session (CP = +0...
September 7, 2016: Nutrients
https://www.readbyqxmd.com/read/27574342/radical-vaginal-trachelectomy-with-laparoscopic-pelvic-lymphadenectomy-for-fertility-preservation-in-young-women-with-early-stage-cervical-cancer
#18
Elvira Brătilă, C P Brătilă, C B Coroleuca
The primary objective of this study was to describe our experience with the conservative treatment of early-stage cervical cancer (stages IA1, IA2, and IB1) with radical vaginal trachelectomy (RVT) and laparoscopic pelvic lymphadenectomy. This retrospective observational case series included 36 patients with early cervical cancer. Radical trachelectomy and laparoscopic pelvic lymphadenectomy were performed as described by D. Dargent in 32 of these cases. Oncologic, reproductive, and obstetric outcomes were observed subsequently over a median period of 42 (24-96) weeks...
August 2016: Indian Journal of Surgery
https://www.readbyqxmd.com/read/27538867/hydrogen-sulfide-a-novel-mechanism-for-the-vascular-protection-by-resveratrol-under-oxidative-stress-in-mouse-aorta
#19
Gunay Yetik-Anacak, Gulnur Sevin, Ozge Ozzayım, Mehmet Vehbi Dereli, Asif Ahmed
Reactive oxygen species (ROS) decreases bioavailability of nitric oxide (NO) and impairs NO-dependent relaxations. Like NO, hydrogen sulfide (H2S) is an antioxidant and vasodilator; however, the effect of ROS on H2S-induced relaxations is unknown. Here we investigated whether ROS altered the effect of H2S on vascular tone in mouse aorta and determined whether resveratrol (RVT) protects it via H2S. Pyrogallol induced ROS formation. It also decreased H2S formation and relaxation induced by l-cysteine and in mouse aorta...
December 2016: Vascular Pharmacology
https://www.readbyqxmd.com/read/27509464/resveratrol-treatment-prevents-hippocamal-neurodegeneration-in-a-rodent-model-of-traumatic-brain-injury
#20
Tugay Atalay, Ismail Gulsen, Nese Colcimen, Hamit Hakan Alp, Enver Sosuncu, Ilker Alaca, Hakan Ak, Murat Cetin Ragbetli
AIM: Traumatic brain injury (TBI) is a complex process that increasing evidence has demonstrated that reactive oxygen species contribute to brain injury. Revesterol (RVT), which exhibits significant antioxidant properties, is neuroprotective against excitotoxicity, ischemia, and hypoxia. Our aim was to evaluate the neuroprotective effects of RVT on the hippocampus in a rat model of TBI. MATERIAL AND METHODS: Seven rats were divided into four. A moderate degree of head trauma was induced using Feeney's falling weight technique...
May 25, 2016: Turkish Neurosurgery
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