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Andrew C D'Lugos, Nicholas D Luden, Justin M Faller, Jeremy D Akers, Alec I McKenzie, Michael J Saunders
The effects of protein supplementation on cycling performance, skeletal muscle function, and heart rate responses to exercise were examined following intensified (ICT) and reduced-volume training (RVT). Seven cyclists performed consecutive periods of normal training (NT), ICT (10 days; average training duration 220% of NT), and RVT (10 days; training duration 66% of NT). In a crossover design, subjects consumed supplemental carbohydrate (CHO) or an equal amount of carbohydrate with added protein (CP) during and following each exercise session (CP = +0...
2016: Nutrients
Elvira Brătilă, C P Brătilă, C B Coroleuca
The primary objective of this study was to describe our experience with the conservative treatment of early-stage cervical cancer (stages IA1, IA2, and IB1) with radical vaginal trachelectomy (RVT) and laparoscopic pelvic lymphadenectomy. This retrospective observational case series included 36 patients with early cervical cancer. Radical trachelectomy and laparoscopic pelvic lymphadenectomy were performed as described by D. Dargent in 32 of these cases. Oncologic, reproductive, and obstetric outcomes were observed subsequently over a median period of 42 (24-96) weeks...
August 2016: Indian Journal of Surgery
Yetik-Anacak Gunay, Sevin Gulnur, Ozzayım Ozge, Dereli Mehmet Vehbi, Ahmed Asif
Reactive oxygen species (ROS) decreases bioavailability of nitric oxide (NO) and impairs NO-dependent relaxations. Like NO, hydrogen sulfide (H2S) is an antioxidant and vasodilator; however, the effect of ROS on H2S-induced relaxations is unknown. Here we investigated whether ROS altered the effect of H2S on vascular tone in mouse aorta and determined whether resveratrol (RVT) protects it via H2S. Pyrogallol induced ROS formation. It also decreased H2S formation and relaxation induced by l-cysteine and in mouse aorta...
August 15, 2016: Vascular Pharmacology
Tugay Atalay, Ismail Gulsen, Nese Colcimen, Hamit Hakan Alp, Enver Sosuncu, Ilker Alaca, Hakan Ak, Murat Cetin Ragbetli
AIM: Traumatic brain injury (TBI) is a complex process that increasing evidence has demonstrated that reactive oxygen species contribute to brain injury. Revesterol (RVT), which exhibits significant antioxidant properties, is neuroprotective against excitotoxicity, ischemia, and hypoxia. Our aim was to evaluate the neuroprotective effects of RVT on the hippocampus in a rat model of TBI. MATERIAL AND METHODS: Seven rats were divided into four. A moderate degree of head trauma was induced using Feeney's falling weight technique...
May 25, 2016: Turkish Neurosurgery
Seda Sultan Uğurel, Nilay Kuşçu, Çiler Çelik Özenci, Selvinaz Dalaklıoğlu, Arda Taşatargil
BACKGROUND: The cardiovascular benefits of Resveratrol (RVT) have been well established by previous experimental and clinical studies. AIMS: The goal of this study was to test the effectiveness of RVT administration on the impaired endothelial function induced by lipopolysaccharide (LPS), and to elucidate the role of endothelial nitric oxide synthase (eNOS)/Sirtuin 1 (SIRT1) pathway. STUDY DESIGN: Animal experiment. METHODS: Endotoxemia was induced by intraperitoneal injection of 10 mg/kg LPS, and the thoracic aorta was isolated six hours later...
March 2016: Balkan Medical Journal
Cesare Granata, Rodrigo S F Oliveira, Jonathan P Little, Kathrin Renner, David J Bishop
Increased mitochondrial content and respiration have both been reported after exercise training. However, no study has directly compared how different training volumes influence mitochondrial respiration and markers of mitochondrial biogenesis. Ten healthy men performed high-intensity interval cycling during 3 consecutive training phases; 4 wk of normal-volume training (NVT; 3/wk), followed by 20 d of high-volume training (HVT; 2/d) and 2 wk of reduced-volume training (RVT; 5 sessions). Resting biopsy samples (vastus lateralis) were obtained at baseline and after each phase...
July 11, 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Karen Poon, Lexin Liang, Chang Xu
OBJECTIVE: To monitor current production in Qi-deficient liver cells, and to study how cellular proton leakage might affect electric current production. METHODS: Cells were placed in an microbial fuel cells (MFC) anode and the electric current was measured. Mitochondrial-affecting chemicals, 2,4-dinitrophenol (DNP) and resveratrol (RVT), were used to induce proton leakage in cells and their effect on current production observed. MCF-7 breast cancer cells exhibited higher proton leakage relative to normal liver cells...
April 2016: Journal of Traditional Chinese Medicine, Chung i Tsa Chih Ying Wen Pan
N M W J de Bruin, A van Loevezijn, K M Wicke, M de Haan, J Venhorst, J H M Lange, L de Groote, M A W van der Neut, J Prickaerts, E Andriambeloson, A G Foley, M van Drimmelen, M van der Wetering, C G Kruse
In the present study, our aim was to investigate whether the novel highly selective 5-hydroxytryptamine6 (5-HT6) receptor antagonist SLV can ameliorate impairments in cognition and social interaction with potential relevance for both schizophrenia and Alzheimer's disease (AD). SLV sub-chronically - treated Wistar rats reared in isolation showed significantly enhanced prepulse inhibition (PPI) and object recognition performance when compared to vehicle - treated rats. In the isolated rats, also a significant reduction in expression of hippocampal neural cell adhesion molecule polysialylation (NCAM-PSA) was found which was ameliorated following treatment with SLV (30mg/kg)...
September 2016: Neurobiology of Learning and Memory
S Dalaklioglu, Z Bayram, A Tasatargil, S Ozdem
BACKGROUND: The aim of this study was to investigate the effect of resveratrol (RVT) on sildenafil-induced relaxations of isolated corpus cavernosum in non-diabetic and diabetic aged rats. METHODS: A total of 13 male aged rats (72-80 weeks old) were randomized into two groups including non-diabetic aged rats and diabetic aged rats. Diabetes was induced in aged rats by streptozotocin (single i.p. dose of 45 mg/kg body weight) administration. At the end of the 12th week, corpus cavernosum strips of rats were suspended in an organ bath system...
May 11, 2016: Aging Clinical and Experimental Research
A Young, J Phillips, H Hancocks, C Hill, N Joshi, A Marshall, J Grumett, J A Dunn, A Lokare, O Chapman
INTRODUCTION: Venous thromboembolism (VTE) in cancer patients is an increasingly frequent clinical problem. The overall impact of VTE on cancer patients can be considerable. Targeted patient selection by identifying patients with clinically significant recurrent VTE may have wider health economic benefits whilst reducing patient risk through over-treatment. In the UK, dalteparin is one licensed anticoagulant for the extended treatment and prevention of recurrence of VTE in cancer patients...
April 2016: Thrombosis Research
Sakhila K Banu, Jone A Stanley, Kirthiram K Sivakumar, Joe A Arosh, Robert C Burghardt
Resveratrol (RVT), a polyphenolic component in grapes and red wine, has been known for its cytoprotective actions against several diseases. However, beneficial effects of RVT against early exposure to endocrine disrupting chemicals (EDCs) have not been understood. EDCs are linked to several ovarian diseases such as premature ovarian failure, polycystic ovary syndrome, early menopause and infertility in women. Hexavalent chromium (CrVI) is a heavy metal EDC, and widely used in >50 industries. Environmental contamination with CrVI in the US is rapidly increasing, predisposing the human to several illnesses including cancers and still birth...
July 15, 2016: Toxicology and Applied Pharmacology
Chien-Boon Jong, Wei-Yung Lo, Mu-Yang Hsieh
We report our experience using catheter-directed thrombectomy/thrombolysis (CDT) to treat a patient with acute renal vein thrombosis (RVT) associated with systemic lupus erythematosus (SLE). A 34-year-old woman presented with persistent left flank pain, and a renal ultrasonography examination revealed an enlarged left kidney. Contrast-enhanced computed tomography confirmed the presence of acute left RVT. Because medical treatment failed to relieve her pain and the renal function was deteriorating, we attempted to salvage the occluded left renal vein using an endovascular approach...
April 18, 2016: Catheterization and Cardiovascular Interventions
Han Zhang, Yaser Alrajhi, Hamdy El-Hakim
OBJECTIVES: The objectives of this study was to determine variables associated with rVT insertions for rAOM and/or OME in otherwise healthy children. METHODS: This was designed as a retrospectively controlled cohort study. Patients were identified from a prospectively collected surgical database. Eligible subjects were those who had undergone rVT and a consecutive concurrent control group who received only one ventilation tube (VT). Exclusion criteria included craniofacial abnormalities and syndromes...
May 2016: International Journal of Pediatric Otorhinolaryngology
Hong Yan, Zhongyu Liu, Xiaoyu Fu, Yan Li, Hongzhi Che, Rui Mo, Lei Song
OBJECTS: The present study sought to analyze the long-time clinical outcomes of the stage IB1 cervical cancer patients who had received the radical vaginal trachelectomy (RVT) and laparoscopic lymphadenectomy after neoadjuvant chemotherapy (NACT). METHOD: This is a prospective study of 60 patients potentially selected for RVT for a clinical and radiologic cervical cancer (stages IB 1) less than 2 cm. These patients were treated with surgery combined with preoperative NACT in the Department of Obstetrics and Gynecology, PLA General Hospital...
May 2016: International Journal of Surgery
Amihai Rottenstreich, Merav Barzilai, Nael Da'as, Geffen Kleinstern, David Varon, Yosef Kalish
BACKGROUND: Renal vein thrombosis (RVT) is a rare event with myriad clinical manifestations. Published experience regarding the clinical course and management of RVT in patients beyond the neonatal period is limited to case reports and small case series. METHODS: A multicenter retrospective review of consecutive admitted patients with diagnosed RVT between January 2000 and May 2015 at three different university hospitals. RESULTS: Thirty-nine patients (53...
February 9, 2016: Clinical and Experimental Nephrology
Lia M Hocke, Yunjie Tong, Kimberly P Lindsey, Blaise de B Frederick
PURPOSE: Functional MRI (fMRI) blood-oxygen level-dependent (BOLD) signals result not only from neuronal activation, but also from nonneuronal physiological processes. These changes, especially in the low-frequency domain (0.01-0.2 Hz), can significantly confound inferences about neuronal processes. It is crucial to effectively identify these nuisance low-frequency oscillations (LFOs). METHOD: A high temporal resolution (repetition time, ∼0.5 s) fMRI resting state study was conducted with simultaneous physiological measurements to compare LFOs measured directly by near-infrared spectroscopy (NIRS) in the periphery and three methods that model LFOs from the respiration or cardiac signal: 1) the respiration volume per time (RVT), 2) the respiratory variation (RVRRF), and 3) the cardiac variation method (HRCRF)...
February 7, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
Ayumi Taguchi, Kaori Koga, Kei Kawana, Tomoko Makabe, Fusako Sue, Mariko Miyashita, Mitsuyo Yoshida, Yoko Urata, Gentaro Izumi, Masashi Tkamura, Miyuki Harada, Tetsuya Hirata, Yasushi Hirota, Osamu Wada-Hiraike, Tomoyuki Fujii, Yutaka Osuga
PROBLEM: Resistance to apoptosis, together with inflammatory and invasive activity, contributes to the pathogenesis of endometriosis; therefore, approaches that can safely enhance apoptosis in endometriotic tissue are highly sought after as a means of managing the disease. Although resveratrol (RVT) is known to induce apoptosis or increase sensitivity to apoptotic stimuli in various cancer cell types, its effect on human endometriosis has remained uncertain. This study aimed to investigate whether RVT induces or enhances apoptosis in human endometriotic stromal cells (ESCs)...
April 2016: American Journal of Reproductive Immunology: AJRI
Gabriela da Rocha Lindner, Luciana Facco Dalmolin, Najeh Maissar Khalil, Rubiana Mara Mainardes
Polymeric nanoparticles are colloidal systems that promote protection and modification of physicochemical characteristics of a drug and that also ensure controlled and extended drug release. This paper reports a 2(3) factorial design study to optimize poly(lactide) (PLA) and poly(lactide)-polyethylene glycol (PLA-PEG) blend nanoparticles containing resveratrol (RVT) for prolonged release. The independent variables analyzed were solvent composition, surfactant concentration and ratio of aqueous to organic phase (two levels each factor)...
December 2015: Journal of Nanoscience and Nanotechnology
Habib Ghaznavi, Zahra Soheili, Shahram Samiei, Mohammad Soleiman Soltanpour
There are limited data regarding the role of methylene tetrahydrofolate reductase (MTHFR) A1298C polymorphism and hyperhomocysteinemia as risk factors for retinal vein thrombosis (RVT) in Iranians. This study aimed to examine a possible association between fasting plasma total homocysteine (tHcy) levels, MTHFR A1298C polymorphism and RVT development in Iranian patients. Our study population consisted of 73 patients with a diagnosis of RVT (52.7 ± 16.2 years) and 73 age and sex-matched healthy controls (49...
September 2016: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
Gunay Yetik-Anacak, Mehmet V Dereli, Gulnur Sevin, Ozge Ozzayım, Yasemin Erac, Asif Ahmed
INTRODUCTION: Resveratrol (RVT) found in red wine protects against erectile dysfunction and relaxes penile tissue (corpus cavernosum) via a nitric oxide (NO) independent pathway. However, the mechanism remains to be elucidated. Hydrogen sulfide (H2 S) is a potent vasodilator and neuromodulator generated in corpus cavernosum. AIMS: We investigated whether RVT caused the relaxation of mice corpus cavernosum (MCC) through H2 S. METHODS: H2 S formation is measured by methylene blue assay and vascular reactivity experiments have been performed by DMT strip myograph in CD1 MCC strips...
October 2015: Journal of Sexual Medicine
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