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https://www.readbyqxmd.com/read/27902473/rituximab-conjugated-doxorubicin-loaded-microbubbles-as-a-theranostic-modality-in-b-cell-lymphoma
#1
Shoubing Zhou, Xiu Zhang, Cailian Wang
This study evaluated rituximab-conjugated, doxorubicin-loaded microbubbles (RDMs) in combination with ultrasound as molecular imaging agents for early diagnosis of B cell lymphomas, and as a targeted drug delivery system. Rituximab, a monoclonal CD20 antibody, was attached to the surfaces of doxorubicin-loaded microbubbles. RDM binding to B cell lymphoma cells was assessed using immunofluorescence. The cytotoxic effects of RDMs in combination with ultrasound (RDMs+US) were evaluated in vitro in CD20+ and CD20- cell lines, and its antitumor activities were assessed in Raji (CD20+) and Jurkat (CD20-) lymphoma cell-grafted mice...
November 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27899667/rice-snp-seek-database-update-new-snps-indels-and-queries
#2
Locedie Mansueto, Roven Rommel Fuentes, Frances Nikki Borja, Jeffery Detras, Juan Miguel Abriol-Santos, Dmytro Chebotarov, Millicent Sanciangco, Kevin Palis, Dario Copetti, Alexandre Poliakov, Inna Dubchak, Victor Solovyev, Rod A Wing, Ruaraidh Sackville Hamilton, Ramil Mauleon, Kenneth L McNally, Nickolai Alexandrov
We describe updates to the Rice SNP-Seek Database since its first release. We ran a new SNP-calling pipeline followed by filtering that resulted in complete, base, filtered and core SNP datasets. Besides the Nipponbare reference genome, the pipeline was run on genome assemblies of IR 64, 93-11, DJ 123 and Kasalath. New genotype query and display features are added for reference assemblies, SNP datasets and indels. JBrowse now displays BAM, VCF and other annotation tracks, the additional genome assemblies and an embedded VISTA genome comparison viewer...
November 29, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27802640/variational-optimization-of-the-two-electron-reduced-density-matrix-under-pure-state-n-representability-conditions
#3
A Eugene DePrince
The direct variational optimization of the ground-state two-electron reduced-density matrix (2-RDM) is typically performed under ensemble N-representability conditions. Accordingly, variationally obtained 2-RDMs for degenerate ground states may not represent a pure state. When considering only ground-state energetics, the ensemble nature of the 2-RDM is of little consequence. However, the use of ensemble densities within an extended random phase approximation (ERPA) yields astonishingly poor estimates of excitation energies, even for simple atomic systems [H...
October 28, 2016: Journal of Chemical Physics
https://www.readbyqxmd.com/read/27574316/inferring-brain-computational-mechanisms-with-models-of-activity-measurements
#4
Nikolaus Kriegeskorte, Jörn Diedrichsen
High-resolution functional imaging is providing increasingly rich measurements of brain activity in animals and humans. A major challenge is to leverage such data to gain insight into the brain's computational mechanisms. The first step is to define candidate brain-computational models (BCMs) that can perform the behavioural task in question. We would then like to infer which of the candidate BCMs best accounts for measured brain-activity data. Here we describe a method that complements each BCM by a measurement model (MM), which simulates the way the brain-activity measurements reflect neuronal activity (e...
October 5, 2016: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/27337104/arginine-demethylation-is-catalysed-by-a-subset-of-jmjc-histone-lysine-demethylases
#5
Louise J Walport, Richard J Hopkinson, Rasheduzzaman Chowdhury, Rachel Schiller, Wei Ge, Akane Kawamura, Christopher J Schofield
While the oxygen-dependent reversal of lysine N(ɛ)-methylation is well established, the existence of bona fide N(ω)-methylarginine demethylases (RDMs) is controversial. Lysine demethylation, as catalysed by two families of lysine demethylases (the flavin-dependent KDM1 enzymes and the 2-oxoglutarate- and oxygen-dependent JmjC KDMs, respectively), proceeds via oxidation of the N-methyl group, resulting in the release of formaldehyde. Here we report detailed biochemical studies clearly demonstrating that, in purified form, a subset of JmjC KDMs can also act as RDMs, both on histone and non-histone fragments, resulting in formaldehyde release...
June 23, 2016: Nature Communications
https://www.readbyqxmd.com/read/26963813/fast-mode-decision-in-the-hevc-video-coding-standard-by-exploiting-region-with-dominated-motion-and-saliency-features
#6
Pallab Kanti Podder, Manoranjan Paul, Manzur Murshed
The emerging High Efficiency Video Coding (HEVC) standard introduces a number of innovative and powerful coding tools to acquire better compression efficiency compared to its predecessor H.264. The encoding time complexities have also increased multiple times that is not suitable for realtime video coding applications. To address this limitation, this paper employs a novel coding strategy to reduce the time complexity in HEVC encoder by efficient selection of appropriate block-partitioning modes based on human visual features (HVF)...
2016: PloS One
https://www.readbyqxmd.com/read/26718487/rituximab-conjugated-and-doxorubicin-loaded-microbubbles-combined-with-ultrasound-irradiation-inhibits-proliferation-and-induces-apoptosis-in-raji-cell-lines
#7
Shoubing Zhou, Shiya Zheng, Yongfeng Shan, Lulu Li, Xiu Zhang, Cailian Wang
Doxorubicin (DOX) is one of the most important medicines used for the treatment for B cell lymphoma, yet its clinical efficacy is often limited by severe adverse effects. Drug-loaded microbubbles, combined with ultrasound (US) irradiation, has shown great promise in reducing DOX-induced side effects and improving therapeutic efficacy. Nevertheless, these drug-loaded microbubbles are non-targeted microbubbles with comparatively suboptimal efficiency. Therefore, we synthesized targeted and DOX-loaded microbubbles (DMs), combined with US irradiation, for triggering drug release in lymphoma B cells...
February 2016: Oncology Reports
https://www.readbyqxmd.com/read/26326777/the-effects-of-recurrent-dynamics-on-ventral-stream-representational-geometry
#8
Seyed-Mahdi Khaligh-Razavi, Johan Carlin, Radoslaw Martin Cichy, Nikolaus Kriegeskorte
Visual processing involves feedforward and recurrent signals. Understanding which computations are performed in the feedforward sweep and which require recurrent processing has been challenging. We used fMRI and MEG to characterize the spatial and temporal components of human visual object representations. In the fMRI experiment, we used brief stimulus presentation (16.7ms) and a backward masking paradigm with short and long interstimulus intervals (ISI) to distinguish the contributions of feedforward and recurrent processing...
2015: Journal of Vision
https://www.readbyqxmd.com/read/26326679/spatio-temporal-uncertainty-and-cortical-hippocampal-interactions-fmri-study
#9
Nisha Dalal, Virginia Flanagin, Stefan Glasauer
INTRODUCTION: The hippocampus interacts with early visual cortex in a stimulus-dependent way. Previously our lab reported that when participants watched movement through a virtual tunnel there was a weaker correlation between the hippocampus and primary visual cortex than with videos where the phase content was scrambled (Figure S1). The hippocampus may provide an important function in interpreting unpredictable input. Here, we test this hypothesis using a similar fMRI paradigm, together with univariate and representational similarity analyses...
2015: Journal of Vision
https://www.readbyqxmd.com/read/26305097/undesirable-choice-biases-with-small-differences-in-the-spatial-structure-of-chance-stimulus-sequences
#10
David Herrera, Mario Treviño
In two-alternative discrimination tasks, experimenters usually randomize the location of the rewarded stimulus so that systematic behavior with respect to irrelevant stimuli can only produce chance performance on the learning curves. One way to achieve this is to use random numbers derived from a discrete binomial distribution to create a 'full random training schedule' (FRS). When using FRS, however, sporadic but long laterally-biased training sequences occur by chance and such 'input biases' are thought to promote the generation of laterally-biased choices (i...
2015: PloS One
https://www.readbyqxmd.com/read/25896934/visual-representations-are-dominated-by-intrinsic-fluctuations-correlated-between-areas
#11
Linda Henriksson, Seyed-Mahdi Khaligh-Razavi, Kendrick Kay, Nikolaus Kriegeskorte
Intrinsic cortical dynamics are thought to underlie trial-to-trial variability of visually evoked responses in animal models. Understanding their function in the context of sensory processing and representation is a major current challenge. Here we report that intrinsic cortical dynamics strongly affect the representational geometry of a brain region, as reflected in response-pattern dissimilarities, and exaggerate the similarity of representations between brain regions. We characterized the representations in several human visual areas by representational dissimilarity matrices (RDMs) constructed from fMRI response-patterns for natural image stimuli...
July 1, 2015: NeuroImage
https://www.readbyqxmd.com/read/25577316/the-effects-of-responsible-drinking-messages-on-attentional-allocation-and-drinking-behaviour
#12
Antony C Moss, Ian P Albery, Kyle R Dyer, Daniel Frings, Karis Humphreys, Thomas Inkelaar, Emily Harding, Abbie Speller
AIMS: Four experiments were conducted to assess the acute impact of context and exposure to responsible drinking messages (RDMs) on attentional allocation and drinking behaviour of younger drinkers and to explore the utility of lab-based methods for the evaluation of such materials. METHODS: A simulated bar environment was used to examine the impact of context, RDM posters, and brief online responsible drinking advice on actual drinking behaviour. Experiments one (n = 50) and two (n = 35) comprised female non-problem drinkers, whilst Experiments three (n = 80) and 4 (n = 60) included a mixed-gender sample of non-problem drinkers, recruited from an undergraduate student cohort...
May 2015: Addictive Behaviors
https://www.readbyqxmd.com/read/25375136/deep-supervised-but-not-unsupervised-models-may-explain-it-cortical-representation
#13
Seyed-Mahdi Khaligh-Razavi, Nikolaus Kriegeskorte
Inferior temporal (IT) cortex in human and nonhuman primates serves visual object recognition. Computational object-vision models, although continually improving, do not yet reach human performance. It is unclear to what extent the internal representations of computational models can explain the IT representation. Here we investigate a wide range of computational model representations (37 in total), testing their categorization performance and their ability to account for the IT representational geometry. The models include well-known neuroscientific object-recognition models (e...
November 2014: PLoS Computational Biology
https://www.readbyqxmd.com/read/24746426/rdms-certification-for-emergency-physicians
#14
Resa E Lewiss, Michael Stone
No abstract text is available yet for this article.
May 2014: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/24746425/rdms-ultrasound-certification-for-emergency-physicians
#15
Romolo J Gaspari, John Bailitz
No abstract text is available yet for this article.
May 2014: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/24721414/-acute-cough-in-infants-impact-of-national-guidelines-on-medical-practices-in-a-french-department
#16
F Alauzet, M-C Banide, C Pailhes, S Blanc, I Montaudié, C Piccini-Bailly, M Berlioz-Baudoin, M Bégassat, M Albertini, L Giovannini-Chami
CONTEXT AND AIM: Guidelines have been published regularly since 2010 by the ANSM (the Health Products Safety Agency) advising against antitussive drugs for infants because of their inefficacy and their side effects (convulsions, respiratory congestion). Antihistamines, mucolytics, and terpene-based suppositories have theoretically disappeared from infant pharmacopoeia. We assessed the degree of compliance with these guidelines on the part of health professionals. MATERIALS AND METHODS: From June 2012 to August 2012, 198 general practitioners and 44 pediatricians were assessed in the Alpes-Maritimes department of France by means of questionnaires...
May 2014: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/24387056/molecule-optimized-basis-sets-and-hamiltonians-for-accelerated-electronic-structure-calculations-of-atoms-and-molecules
#17
Gergely Gidofalvi, David A Mazziotti
Molecule-optimized basis sets, based on approximate natural orbitals, are developed for accelerating the convergence of quantum calculations with strongly correlated (multireferenced) electrons. We use a low-cost approximate solution of the anti-Hermitian contracted Schrödinger equation (ACSE) for the one- and two-electron reduced density matrices (RDMs) to generate an approximate set of natural orbitals for strongly correlated quantum systems. The natural-orbital basis set is truncated to generate a molecule-optimized basis set whose rank matches that of a standard correlation-consistent basis set optimized for the atoms...
January 16, 2014: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/24320307/communication-reduced-density-matrices-in-molecular-systems-grand-canonical-electron-states
#18
Roberto C Bochicchio, Ramón A Miranda-Quintana, Diego Rial
Grand-canonical like descriptions of many electron atomic and molecular open systems which are characterized by a non-integer number of electrons are presented. Their associated reduced density matrices (RDMs) are obtained by introducing the contracting mapping for this type of distributions. It is shown that there is loss of information when connecting RDMs of different order by partial contractions. The energy convexity property of these systems simplifies the description. Consequently, this formulation opens the possibility to a new look for chemical descriptors such as chemical potential and reactivity among others...
November 21, 2013: Journal of Chemical Physics
https://www.readbyqxmd.com/read/24276553/the-mcart-radiation-physics-core-the-quest-for-radiation-dosimetry-standardization
#19
Abdul M Kazi, Thomas J MacVittie, Giovanni Lasio, Wei Lu, Karl L Prado
Dose-related radiobiological research results can only be compared meaningfully when radiation dosimetry is standardized. To this purpose, the National Institute of Allergy and Infectious Diseases (NIAID)-sponsored Medical Countermeasures Against Radiological Threats (MCART) consortium recently created a Radiation Physics Core (RPC) as an entity to assume responsibility of standardizing radiation dosimetry practices among its member laboratories. The animal research activities in these laboratories use a variety of ionizing photon beams from several irradiators such as 250-320 kVp x-ray generators, Cs irradiators, Co teletherapy machines, and medical linear accelerators (LINACs)...
January 2014: Health Physics
https://www.readbyqxmd.com/read/23974203/genome-wide-dna-methylation-analysis-identifies-hypomethylated-genes-regulated-by-foxp3-in-human-regulatory-t-cells
#20
Yuxia Zhang, Jovana Maksimovic, Gaetano Naselli, Junyan Qian, Michael Chopin, Marnie E Blewitt, Alicia Oshlack, Leonard C Harrison
Regulatory T cells (Treg) prevent the emergence of autoimmune disease. Prototypic natural Treg (nTreg) can be reliably identified by demethylation at the Forkhead-box P3 (FOXP3) locus. To explore the methylation landscape of nTreg, we analyzed genome-wide methylation in human naive nTreg (rTreg) and conventional naive CD4(+) T cells (Naive). We detected 2315 differentially methylated cytosine-guanosine dinucleotides (CpGs) between these 2 cell types, many of which clustered into 127 regions of differential methylation (RDMs)...
October 17, 2013: Blood
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