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https://www.readbyqxmd.com/read/29456841/successful-treatment-of-extensively-drug-resistant-acinetobacter-baumannii-ventriculitis-with-polymyxin-b-and-tigecycline-a-case-report
#1
Wei Guo, Shao-Chun Guo, Min Li, Li-Hong Li, Yan Qu
Background: Acinetobacter baumannii nosocomial ventriculitis/meningitis, especially those due to drug-resistant strains, has substantially increased over recent years. However, limited therapeutic options exist for the Acinetobacter baumannii ventriculitis/meningitis because of the poor penetration rate of most antibiotics through the blood-brain barrier. Case presentation: A 57-year-old male patient developed ventriculitis from an extensively drug-resistant strain of Acinetobacter baumannii after the decompressive craniectomy for severe traumatic brain injury...
2018: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29456525/kinetics-and-novel-degradation-pathway-of-permethrin-in-acinetobacter-baumannii-zh-14
#2
Hui Zhan, Huishan Wang, Lisheng Liao, Yanmei Feng, Xinghui Fan, Lianhui Zhang, Shaohua Chen
Persistent use of permethrin has resulted in its ubiquitous presence as a contaminant in surface streams and soils, yet little is known about the kinetics and metabolic behaviors of this pesticide. In this study, a novel bacterial strain Acinetobacter baumannii ZH-14 utilizing permethrin via partial hydrolysis pathways was isolated from sewage sludge. Response surface methodology based on Box-Behnken design of cultural conditions was used for optimization resulting in 100% degradation of permethrin (50 mg·L-1 ) within 72 h...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29456043/colistin-alone-versus-colistin-plus-meropenem-for-treatment-of-severe-infections-caused-by-carbapenem-resistant-gram-negative-bacteria-an-open-label-randomised-controlled-trial
#3
Mical Paul, George L Daikos, Emanuele Durante-Mangoni, Dafna Yahav, Yehuda Carmeli, Yael Dishon Benattar, Anna Skiada, Roberto Andini, Noa Eliakim-Raz, Amir Nutman, Oren Zusman, Anastasia Antoniadou, Pia Clara Pafundi, Amos Adler, Yaakov Dickstein, Ioannis Pavleas, Rosa Zampino, Vered Daitch, Roni Bitterman, Hiba Zayyad, Fidi Koppel, Inbar Levi, Tanya Babich, Lena E Friberg, Johan W Mouton, Ursula Theuretzbacher, Leonard Leibovici
BACKGROUND: Colistin-carbapenem combinations are synergistic in vitro against carbapenem-resistant Gram-negative bacteria. We aimed to test whether combination therapy improves clinical outcomes for adults with infections caused by carbapenem-resistant or carbapenemase-producing Gram-negative bacteria. METHODS: A randomised controlled superiority trial was done in six hospitals in Israel, Greece, and Italy. We included adults with bacteraemia, ventilator-associated pneumonia, hospital-acquired pneumonia, or urosepsis caused by carbapenem-non-susceptible Gram-negative bacteria...
February 15, 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29453715/the-influence-of-heavy-metals-polyaromatic-hydrocarbons-and-polychlorinated-biphenyls-pollution-on-the-development-of-antibiotic-resistance-in-soils
#4
Andrey Vladimirovich Gorovtsov, Ivan Sergeevich Sazykin, Marina Alexandrovna Sazykina
The minireview is devoted to the analysis of the influence of soil pollution with heavy metals, polyaromatic hydrocarbons (PAHs), and the polychlorinated biphenyls (PCBs) on the distribution of antibiotics resistance genes (ARGs) in soil microbiomes. It is shown that the best understanding of ARGs distribution process requires studying the influence of pollutants on this process in natural microbiocenoses. Heavy metals promote co-selection of genes determining resistance to them together with ARGs in the same mobile elements of a bacterial genome, but the majority of studies focus on agricultural soils enriched with ARGs originating from manure...
February 16, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29449171/changes-in-antimicrobial-susceptibility-of-commonly-clinically-significant-isolates-before-and-after-the-interventions-on-surgical-prophylactic-antibiotics-spas-in-shanghai
#5
Su Wang, Li-Zhong Han, Yu-Xing Ni, Yi-Bo Zhang, Qun Wang, Da-Ke Shi, Wen-Hui Li, Yi-Chen Wang, Chen-Rong Mi
Surveillances and interventions on antibiotics use have been suggested to improve serious drug-resistance worldwide. Since 2007, our hospital have proposed many measures for regulating surgical prophylactic antibiotics (carbapenems, third gen. cephalosporins, vancomycin, etc.) prescribing practices, like formulary restriction or replacement for surgical prophylactic antibiotics and timely feedback. To assess the impacts on drug-resistance after interventions, we enrolled infected patients in 2006 (pre-intervention period) and 2014 (post-intervention period) in a tertiary hospital in Shanghai...
February 12, 2018: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/29447223/virome-and-bacteriome-characterization-of-children-with-pneumonia-and-asthma-in-mexico-city-during-winter-seasons-2014-and-2015
#6
Jose A Romero-Espinoza, Yazmin Moreno-Valencia, Rodrigo H Coronel-Tellez, Manuel Castillejos-Lopez, Andres Hernandez, Aaron Dominguez, Angel Miliar-Garcia, Arturo Barbachano-Guerrero, Rogelio Perez-Padilla, Alejandro Alejandre-Garcia, Joel A Vazquez-Perez
BACKGROUND: Acute asthma exacerbations and pneumonia are important causes of morbidity and mortality in children and may coexist in the same children, although symptom overlap may lead to difficulties in diagnosis. Microbial and viral diversity and differential abundance of either may play an important role in infection susceptibility and the development of acute and chronic respiratory diseases. OBJECTIVES: To describe the virome and bacteriome present in the upper respiratory tract of hospitalized children with a clinical diagnosis of asthma and pneumonia during an acute exacerbation and an acute respiratory illness ARI episode respectively...
2018: PloS One
https://www.readbyqxmd.com/read/29446811/nosocomial-infections-current-situation-in-a-resuscitation-unit
#7
Ahlem Trifi, Sami Abdellatif, Mouna Oueslati, Meriem Zribi, Foued Daly, Rochdi Nasri, Rahma Mannai, Chadlia Fandri, Salah Ben Lakhal
BACKGROUND: The nosocomial infection (NI) is defined as an infection that is not present or incubating on admission in establishment of care. It can be caused by the patient's germs, care personnel or hospital environment. Multidrug resistant (MDR) bacteria are particularly common in intensive care units that lead to a serious infections and increase morbidity, mortality and cost of care. PURPOSE: To identify the epidemiological characteristics of NI, the predisposing factors, the antimicrobial sensitivity pattern of isolated bacteria and the impact on morbidity and mortality...
March 2017: La Tunisie Médicale
https://www.readbyqxmd.com/read/29442713/antibacterial-activities-of-bacteriagenic-silver-nanoparticles-against-nosocomial-acinetobacter-baumannii
#8
Richa Singh, Jeet Vora, Shradhda B Nadhe, Sweety A Wadhwani, Utkarsha U Shedbalkar, Balu A Chopade
Acinetobacter baumannii has emerged as one of the major nosocomial pathogens implicated in variety of severe infections and mortality. It is rapidly developing multi-drug resistance and also possesses surface colonization ability, which make it most difficult to treat through traditional antibiotics. This is an extensive study to describe the antibacterial activity of bacteriagenic silver nanoparticles (AgNPs) against A. baumannii AIIMS 7 in planktonic and biofilm mode. Minimum inhibitory concentration of antibiotics were in the range of 1 to 4096 μg/ml whereas AgNPs inhibited planktonic bacteria at concentration of 16 μg/ml...
June 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29438671/the-structure-of-the-biofilm-controlling-response-regulator-bfmr-from-acinetobacter-baumannii-reveals-details-of-its-dna-binding-mechanism
#9
G Logan Draughn, Morgan E Milton, Erik A Feldmann, Benjamin G Bobay, Braden M Roth, Andrew L Olson, Richele J Thompson, Luis A Actis, Christopher Davies, John Cavanagh
The rise of drug-resistant bacterial infections coupled with decreasing antibiotic efficacy poses a significant challenge to global healthcare. Acinetobacter baumannii is an insidious, emerging bacterial pathogen responsible for severe nosocomial infections aided by its ability to form biofilms. The response regulator BfmR, from the BfmR/S two-component system, is the master regulator of biofilm initiation in A. baumannii and is a tractable therapeutic target. Here we present the structure of A. baumannii BfmR using a hybrid approach combining X-ray crystallography, nuclear magnetic resonance spectroscopy, chemical crosslinking mass spectrometry, and molecular modeling...
February 10, 2018: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29437264/insight-on-specificity-of-uracil-permeases-of-the-nat-ncs2-family-from-analysis-of-the-transporter-encoded-in-the-pyrimidine-utilization-operon-of-escherichia-coli
#10
Maria Botou, Panayiota Lazou, Konstantinos Papakostas, George Lambrinidis, Thomas Evangelidis, Emmanuel Mikros, Stathis Frillingos
The uracil permease UraA of Escherichia coli is a structurally known prototype for the ubiquitous Nucleobase-Ascorbate Transporter (NAT) or Nucleobase-Cation Symporter-2 (NCS2) family and represents a well defined subgroup of bacterial homologs that remain functionally unstudied. Here, we analyze four of these homologs, including RutG of E. coli which shares 35% identity with UraA and is encoded in the catabolic rut (pyrimidine utilization) operon. Using amplified expression in E. coli K-12, we show that RutG is a high-affinity permease for uracil, thymine and, at low efficiency, xanthine, and recognizes also 5-fluorouracil and oxypurinol...
February 13, 2018: Molecular Microbiology
https://www.readbyqxmd.com/read/29434938/genetic-characterization-and-in-vitro-activity-of-antimicrobial-combinations-of-multidrug-resistant-acinetobacter-baumannii-from-a-general-hospital-in-china
#11
Fang Chen, Ling Wang, Min Wang, Yixin Xie, Xiaomeng Xia, Xianping Li, Yanhua Liu, Wei Cao, Tingting Zhang, Pengling Li, Min Yang
The present study aimed to develop a rational therapy based on the genetic epidemiology, molecular mechanism evaluation and in vitro antibiotic combinations activity in multidrug-resistant Acinetobacter baumannii (MDRAB). MDRAB was screened by the Kirby-Bauer method. The random amplified polymorphic DNA technique was used to establish genetic fingerprinting, and a series of resistance genes were detected by polymerase chain reaction. Antimicrobial agents including amikacin (AK), cefoperazone/sulbactam (SCF I/II), meropenem (MEM), minocycline (MINO) and ciprofloxacin (CIP) were used to determine the minimum inhibitory concentrations (MICs) and interactions between antibiotics by the broth microdilution method and chequerboard assays...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29434581/site-specific-recombination-at-xerc-d-sites-mediates-the-formation-and-resolution-of-plasmid-co-integrates-carrying-a-blaoxa-58-and-tnapha6-resistance-module-in-acinetobacter-baumannii
#12
María M Cameranesi, Jorgelina Morán-Barrio, Adriana S Limansky, Guillermo D Repizo, Alejandro M Viale
Members of the genus Acinetobacter possess distinct plasmid types which provide effective platforms for the acquisition, evolution, and dissemination of antimicrobial resistance structures. Many plasmid-borne resistance structures are bordered by short DNA sequences providing potential recognition sites for the host XerC and XerD site-specific tyrosine recombinases (XerC/D-like sites). However, whether these sites are active in recombination and how they assist the mobilization of associated resistance structures is still poorly understood...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29434270/expression-and-replication-of-virus-like-circular-dna-in-human-cells
#13
Sebastian Eilebrecht, Agnes Hotz-Wagenblatt, Victor Sarachaga, Amelie Burk, Konstantina Falida, Deblina Chakraborty, Ekaterina Nikitina, Claudia Tessmer, Corinna Whitley, Charlotte Sauerland, Karin Gunst, Imke Grewe, Timo Bund
The consumption of bovine milk and meat is considered a risk factor for colon- and breast cancer formation, and milk consumption has also been implicated in an increased risk for developing Multiple Sclerosis (MS). A number of highly related virus-like DNAs have been recently isolated from bovine milk and sera and from a brain sample of a MS patient. As a genetic activity of these Acinetobacter-related bovine milk and meat factors (BMMFs) is unknown in eukaryotes, we analyzed their expression and replication potential in human HEK293TT cells...
February 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29433997/in-vitro-activities-of-carbapenems-in-combination-with-amikacin-colistin-or-fosfomycin-against-carbapenem-resistant-acinetobacter-baumannii-clinical-isolates
#14
Uthaibhorn Singkham-In, Tanittha Chatsuwan
Carbapenem-resistant Acinetobacter baumannii clinical isolates (n=23) were investigated for carbapenem resistance mechanisms and in vitro activities of carbapenems in combination with amikacin, colistin, or fosfomycin. Major carbapenem resistance mechanism was OXA-23 production. The vast majority of these isolates were OXA-23-producing A. baumannii ST195 and ST542, followed by novel STs, ST1417, and ST1423. The interuption of carO by a novel insertion sequence, ISAba40, was found in two isolates. The combinations of imipenem and fosfomycin, meropenem and amikacin, imipenem and amikacin, and imipenem and colistin were synergistic against carbapenem-resistant A...
January 31, 2018: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29432867/release-of-high-amounts-of-lipopolysaccharides-from-pseudomonas-aeruginosa-cells-reduces-their-susceptibility-to-colistin
#15
Shin-Ichi Yokota, Hiroshi Hakamada, Soh Yamamoto, Toyotaka Sato, Tsukasa Shiraishi, Masaaki Shinagawa, Satoshi Takahashi
Pseudomonas aeruginosa is an important etiological agent of opportunistic infections. Injectable colistin is available as a last-line option of treatment for multidrug-resistant P. aeruginosa infections. When cells were inoculated at a high number, colistin-susceptible P. aeruginosa grew on agar medium containing colistin at a concentration 10-fold higher than the MIC without acquiring colistin resistance. This study examined the responsible mechanism for growth in the presence of a high concentration of colistin...
February 9, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29430818/isolation-and-identification-of-acinetobacter-spp-from-healthy-canine-skin
#16
Kayleigh E Mitchell, Jane F Turton, David H Lloyd
BACKGROUND: Acinetobacter species can exhibit widespread resistance to antimicrobial agents. They are already recognized as important nosocomial pathogens of humans, but are becoming increasingly recognized in opportunistic infections of animals. HYPOTHESIS/OBJECTIVES: This study aimed to determine whether Acinetobacter spp. are carried on skin of healthy dogs and, if present, to identify the species. ANIMALS: Forty dogs were sampled at veterinary practices and rescue centres...
February 11, 2018: Veterinary Dermatology
https://www.readbyqxmd.com/read/29428685/inoculation-with-bacteria-in-floating-treatment-wetlands-positively-modulates-the-phytoremediation-of-oil-field-wastewater
#17
Khadeeja Rehman, Asma Imran, Imran Amin, Muhammad Afzal
The aim of the present study was to investigate the potential of plant-bacterial synergism in floating treatment wetlands (FTWs) for efficient remediation of an oil field wastewater. Two plants, Brachiara mutica and Phragmites australis, were vegetated on floatable mats to develop FTWs, and inoculated with bacterial cons which were then inoculated with a consortium of hydrocarbon-degrading bacteria (Bacillus subtilis strain LORI66, Klebsiella sp. strain LCRI87, Acinetobacter Junii strain TYRH47, Acinetobacter sp...
February 6, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29428610/performance-and-microbial-community-structure-of-a-polar-arctic-circle-aerobic-granular-sludge-system-operating-at-low-temperature
#18
Alejandro Gonzalez-Martinez, Barbara Muñoz-Palazon, Paula Maza-Márquez, Alejandro Rodriguez-Sanchez, Jesus Gonzalez-Lopez, Riku Vahala
The aim of this work was to study the performance and microbial community structure of a polar Arctic Circle aerobic granular sludge (AGS) system operating at low temperature. Thus, an AGS bioreactor was operated at 7, 5 and 3 °C of temperature using a cold-adapted sludge from Lapland. At 5 °C, it yielded acceptable conversion rates, in terms of nitrogen, phosphorous, and organic matter. However, under 3 °C a negligible nitrogen and phosphorous removal performance was observed. Below 5 °C, scanning electron microscopy studies showed a wispy, non-dense and irregular granular structure with a strong outgrowth of filamentous...
February 2, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29427687/rapid-detection-of-carbapenemase-producing-acinetobacter-baumannii-and-carbapenem-resistant-enterobacteriaceae-using-a-bioluminescence-based-phenotypic-method
#19
Vincent van Almsick, Beniam Ghebremedhin, Niels Pfennigwerth, Parviz Ahmad-Nejad
Accurate detection of carbapenem-resistant Enterobacteriaceae (CRE) and carbapenemase-producing carbapenem-resistant Acinetobacter spp. (CP-CRA) constitutes a major challenge in laboratory diagnostics. We developed a bioluminescence-based carbapenem susceptibility detection assay (BCDA) which allows identification of CRE (carbapenemase-producing-CRE (CP-CRE) as well as non-carbapenemase-producing-CRE (non-CP-CRE) and CP-CRA in 2.5 h from culture media. This laboratory method was evaluated with CP-CRE and CP-CRA isolates producing different β-lactamases of different Ambler classes (A, n = 16; B, n = 25; D, n = 67) and 22 non-CP-CRE...
February 7, 2018: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/29427523/meropenem-and-vaborbactam-stepping-up-the-battle-against-carbapenem-resistant-enterobacteriaceae
#20
Sarah Christina Jane Jorgensen, Michael Joseph Rybak
Vaborbactam (VAB; formerly RPX7009) is a novel beta-lactamase inhibitor based on a cyclic boronic acid pharmacophore with potent inhibitory activity against Ambler class A and C beta-lactamases. It has been co-formulated with meropenem to restore its activity against Klebsiella pneumoniae carbapenemases (KPC). VAB does not inhibit class B or D carbapenemases, nor does it improve the activity of meropenem against multidrug-resistant non-fermenting Gram-negative bacilli, notably Acinetobacter spp. and Pseudomonas aeruginosa...
February 10, 2018: Pharmacotherapy
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