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https://www.readbyqxmd.com/read/29474931/alpha-syntrophin-null-mice-are-protected-from-non-alcoholic-steatohepatitis-in-the-methionine-choline-deficient-diet-model-but-not-the-atherogenic-diet-model
#1
Lisa Rein-Fischboeck, Elisabeth M Haberl, Rebekka Pohl, Verena Schmid, Susanne Feder, Sabrina Krautbauer, Gerhard Liebisch, Christa Buechler
Adipose tissue dysfunction contributes to the pathogenesis of non-alcoholic steatohepatitis (NASH). The adapter protein alpha-syntrophin (SNTA) is expressed in adipocytes. Knock-down of SNTA increases preadipocyte proliferation and formation of small lipid droplets, which are both characteristics of healthy adipose tissue. To elucidate a potential protective role of SNTA in NASH, SNTA null mice were fed a methionine-choline-deficient (MCD) diet or an atherogenic diet which are widely used as preclinical NASH models...
February 20, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29465592/urinary-metalloproteinases-and-tissue-inhibitors-of-metalloproteinases-as-potential-early-biomarkers-for-renal-fibrosis-in-children-with-nephrotic-syndrome
#2
Beata Bieniaś, Przemysław Sikora
In chronic glomerulopathies, renal fibrosis (RF) results from extracellular matrix remodeling processes regulated by matrix metalloproteinases (MMP) and tissue inhibitors of metalloproteinases (TIMP). We assessed urinary (u-) and serum (s-) MMP-1, -2, -9, TIMP-1, -2 concentrations and MMP-1, -2, -9/TIMP-1, -2 ratios in children with nephrotic syndrome. Steroid-dependent and steroid-resistant nephrotic patients (SDNS-Ps and SRNS-Ps, respectively) were compared with respect to measured parameters. The correlations of measured parameters with magnitude of proteinuria and histopathological diagnosis were determined...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29465452/web-enabled-mechanistic-case-diagramming-a-novel-tool-for-assessing-students-ability-to-integrate-foundational-and-clinical-sciences
#3
Kristi J Ferguson, Clarence D Kreiter, Thomas H Haugen, Fred R Dee
PROBLEM: As medical schools move from discipline-based courses to more integrated approaches, identifying assessment tools that parallel this change is an important goal. APPROACH: The authors describe the use of test item statistics to assess the reliability and validity of web-enabled mechanistic case diagrams (MCDs) as a potential tool to assess students' ability to integrate basic science and clinical information. Students review a narrative clinical case and construct an MCD using items provided by the case author...
February 20, 2018: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29464958/sp-d-exchange-interactions-in-wave-function-engineered-colloidal-cdse-mn-cds-hetero-nanoplatelets
#4
Franziska Muckel, Savas Delikanli, Pedro Ludwig Hernandez Martinez, Tamara Priesner, Severin Lorenz, Julia Ackermann, Manoj Sharma, Hilmi Volkan Demir, Gerd Bacher
In two-dimensional (2D) colloidal semiconductor nanoplatelets, which are atomically flat nanocrystals, the precise control of thickness and composition on the atomic scale allows for the synthesis of heterostructures with well-defined electron and hole wave function distributions. Introducing transition metal dopants with monolayer precision enables tailored magnetic exchange interactions between dopants and band states. Here, we use the absorption based technique of magnetic circular dichroism (MCD) to directly prove exchange coupling of magnetic dopants with the band charge carriers in shell-doped CdSe/Mn:CdS hetero-nanoplatelets...
February 21, 2018: Nano Letters
https://www.readbyqxmd.com/read/29456749/the-effect-of-canal-fill-on-paediatric-femur-fractures-treated-with-titanium-elastic-nails
#5
E Nielsen, N Bonsu, L M Andras, R Y Goldstein
Purpose: Traditional teaching for fixation of paediatric femur fractures recommends 80% nail diameter/medullary canal diameter ratio (ND/MCD) for successful maintenance of reduction. Prior studies have investigated this with stainless steel Enders nails. Our aim was to assess the impact of ND/MCD on maintenance of reduction and malunion rates in paediatric femur fractures treated with flexible intramedullary nails (FINs). Methods: Retrospective data was collected on all paediatric patients treated with FINs for diaphyseal femur fractures at a single tertiary care institution over a ten-year period...
February 1, 2018: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/29448244/mir-499-ameliorates-podocyte-injury-by-targeting-calcineurin-in-minimal-change-disease
#6
Kaiyue Zhang, Wenjuan Sun, Lai Zhang, Xuefang Xu, Jidong Wang, Yan Hong
BACKGROUND: Podocyte injury is a hallmark of minimal change disease (MCD). Calcineurin inhibitors have been widely used in the current treatment of MCD, and miR-499 may target calcineurin. We aimed to study the function of miR-499 in MCD and test whether miR-499 delivery can improve MCD. METHODS: An MCD mouse model was generated using puromycin aminonucleoside (PAN). MiR-499 was delivered using lentiviruses. Biochemical indicators including serum albumin, triglyceride, cholesterol, and 24-h urine protein were determined...
February 15, 2018: American Journal of Nephrology
https://www.readbyqxmd.com/read/29447645/vulvar-metastatic-crohn-disease-clinical-histopathological-and-ultrasonographic-findings
#7
María Pousa-Martínez, Fernando Alfageme, María Antonia González de Domingo, Dolores Suárez-Masa, Marta Calvo, Gastón Roustán
Metastatic Crohn disease (MCD) is an unusual type of cutaneous Crohn disease characterized by skin lesions separated from the lesions of the gastrointestinal tract. The diagnosis of MCD is essentially histological,showing noncaseating granulomas in the dermis and subcutaneous fat tissue. We report a case of MCD with vulvar involvement and clinical, histopathological, and ultrasonographic findings of this disease.
November 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29444136/ly2405319-an-analog-of-fibroblast-growth-factor-21-ameliorates-%C3%AE-smooth-muscle-actin-production-through-inhibition-of-the-succinate-g-protein-couple-receptor-91-gpr91-pathway-in-mice
#8
Cong Thuc Le, Giang Nguyen, So Young Park, Dae Hee Choi, Eun-Hee Cho
Fibroblast growth factor 21 (FGF21) is an important metabolic regulator expressed predominantly in the liver. In this study, we evaluated the role of LY2405319, an analogue of FGF21, in hepatic stellate cell (HSC) activation and in a methionine and choline-deficient (MCD)-diet induced mouse model of liver fibrosis. During liver injury, HSCs trans-differentiate into activated myofibroblasts which produce alpha-smooth muscle actin (α-SMA) and become a major cell type in hepatic fibrogenesis. Succinate and succinate receptor (GPR91) signaling has emerged as a regulator to promote α-SMA production in MCD diet- induced mice...
2018: PloS One
https://www.readbyqxmd.com/read/29437743/minimal-change-disease-with-maximum-immunosuppression-successful-treatment-of-steroid-dependent-minimal-change-disease-with-rituximab
#9
Helena Pinto, Nuno Oliveira, Fátima Costa, Rui Alves
Minimal change disease (MCD) is usually steroid sensitive, although in case of steroid dependent and multiple relapses we can struggle with different immunosuppressive agents, sometimes with no response. Rituximab has been emerging as an alternative therapeutic option.We describe a case of a young patient with MCD that had frequent relapses and steroid dependency, with no response to several immunosuppressive agents during 15 years of disease. He was kept under high-dose steroids and ciclosporin. He started treatment with rituximab (two administrations of 1 g 2 weeks apart, repeating after 6 months)...
February 5, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29434951/a-retrospective-study-of-34-patients-with-unicentric-and-multicentric-castleman-s-disease-experience-from-a-single-institution
#10
Jin-Peng Jiang, Xiao-Fei Shen, Jun-Feng Du, Wen-Xian Guan
The aim of the present study was to share the experience of a single institute in the diagnosis, use of accessory examinations and treatment strategies of Castleman's disease (CD). The present study analyzed 34 patients (13 males and 21 females) with CD who were hospitalized between January 2006 and September 2014. The patients were divided into two groups based on the anatomical distribution of the disease: Unicentric CD (UCD) and multicentric CD (MCD). Histological data was obtained from lymph node biopsies...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29432915/measuring-adolescent-drinking-refusal-self-efficacy-development-and-validation-of-the-drinking-refusal-self-efficacy-questionnaire-shortened-adolescent-version-drseq-sra
#11
Kiri Patton, Jason P Connor, Sharyn Rundle-Thiele, Timo Dietrich, Ross McD Young, Matthew J Gullo
BACKGROUND: This study aimed to develop and validate a shortened version of the Drinking Refusal Self-Efficacy Questionnaire-Revised Adolescent version (DRSEQ-RA) using a large sample of adolescents. METHODS: Secondary school students (N = 2609, M = 14.52 years, SD = 0.94) completed the DRSEQ-RA (consisting of subscales: Social Pressure; Opportunistic; Emotional Relief) and the Alcohol Use Disorders Identification Test (AUDIT). These data were analysed using non-parametric item response theory (NIRT) including Mokken scalability coefficients, and confirmatory factor analysis...
February 5, 2018: Addictive Behaviors
https://www.readbyqxmd.com/read/29429043/treatment-patterns-healthcare-resource-utilization-and-spending-among-medicaid-enrolled-children-with-chronic-idiopathic-spontaneous-urticaria-in-the-united-states
#12
Paul V Williams, Abhishek Kavati, Dominic Pilon, Yongling Xiao, Maryia Zhdanava, Maria-Magdalena Balp, Patrick Lefebvre, Benjamin Ortiz, Vivian Hernandez-Trujillo
INTRODUCTION: Few studies have described chronic idiopathic/spontaneous urticaria (CIU/CSU) healthcare burden in adults, while this information remains largely unknown in children. We aimed to describe treatment patterns, healthcare resource utilization (HRU), and costs in CIU/CSU pediatric patients, as well as to compare HRU and costs in CIU/CSU and CIU/CSU-free pediatric patients. METHODS: Medicaid claims from four states (09/01/2013-03/31/2016) were used to identify patients less than 12 years old...
February 10, 2018: Dermatology and Therapy
https://www.readbyqxmd.com/read/29426794/spanish-national-hip-fracture-registry-snhfr-a-description-of-its-objectives-methodology-and-implementation
#13
P Sáez-López, J I González-Montalvo, C Ojeda-Thies, J Mora-Fernández, A Muñoz-Pascual, J M Cancio, F J Tarazona, T Pareja, P Gómez-Campelo, N Montero-Fernández, T Alarcón, P Mesa-Lampre, R Larrainzar, E Duaso, E Gil-Garay, A Diéz-Pérez, D Prieto-Alhambra, R Queipo-Matas, A Otero-Puime
OBJECTIVE: To ascertain the current situation and clinical variability of the provision of care for Hip Fracture (HF) in Spain and the factors related to it by using a National Registry (NHFR) with high patient numbers and territorial representation NHFR, and to compare results on a national and international level and propose standards and criteria to improve healthcare quality. DESIGN: Continuous registry for at least three years of a representative sample of patients admitted to Spanish hospitals due to HF using the Minimum Common Dataset - international Fragility Fracture Network (FFN) MCD, adapted for Spanish...
February 6, 2018: Revista Española de Geriatría y Gerontología
https://www.readbyqxmd.com/read/29407734/short-term-assessment-of-cadmium-toxicity-and-uptake-from-different-types-of-cd-based-quantum-dots-in-the-model-plant-allium-cepa-l
#14
Pavlína Modlitbová, Pavel Pořízka, Karel Novotný, Jana Drbohlavová, Ivana Chamradová, Zdeněk Farka, Helena Zlámalová-Gargošová, Tea Romih, Jozef Kaiser
We report on the toxicity and bioaccumulation of three different types of Cd-based quantum dots (QDs), dispersed in aqueous medium, for a model plant Allium cepa L. It is believed that encapsulation of nanoparticles should reduce their toxicity and increase their stability in different environments; in this work we studied how QD encapsulation affects their phytotoxicity. Core, core/shell, and core/shell/shell QDs (CdTe, CdTe/ZnS, and CdTe/CdS/ZnS QDs capped by 2-mercaptopropionic acid) were tested and CdCl2 was used as a positive control...
February 1, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29407685/alcohol-expectancies-pre-and-post-alcohol-use-disorder-treatment-clinical-implications
#15
Jason M Coates, Matthew J Gullo, Gerald F X Feeney, Ross McD Young, Genevieve A Dingle, Jason P Connor
BACKGROUND AND AIMS: Modification of elevated positive expectations of alcohol consumption (alcohol outcome expectancies; AOEs) is a key feature of Cognitive Behaviour Therapy (CBT) approaches to Alcohol Use Disorders (AUDs). Despite extensive research supporting the efficacy of CBT for AUD, few studies have examined AOE change. This study aimed to assess AOE change following completion of CBT for AUD and its association with drinking behaviour. METHOD: One-hundred and seventy-five patients who completed a 12-week CBT program for AUD were administered the Drinking Expectancy Questionnaire (DEQ) at pre-treatment assessment and upon completion of treatment...
January 26, 2018: Addictive Behaviors
https://www.readbyqxmd.com/read/29407218/membrane-cholesterol-removal-and-replenishment-affect-rat-and-monkey-brain-monoamine-transporters
#16
Marc Morissette, Nicolas Morin, Claude Rouillard, Thérèse Di Paolo
The dopamine transporter (DAT) is abundantly expressed in the striatum where it removes extracellular dopamine into the cytosol of presynaptic nerve terminals. It is the target of drugs of abuse and antidepressants. There is a loss of the DAT in Parkinson's disease affecting release of levodopa implicated in levodopa-induced dyskinesias. This study investigated the effect of cholesterol on DAT, serotonin transporter (SERT) and vesicular monoamine transporter 2 (VMAT2) in monkey and rat brains in vitro. DAT protein levels measured by Western blot remained unchanged with in vitro methyl-β-cyclodextrin (MCD) incubations to remove membrane cholesterol or with incubations to increase membrane cholesterol content...
January 30, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29405448/correlation-of-structural-and-magnetic-properties-in-a-set-of-mononuclear-lanthanide-complexes
#17
Peter Comba, Lena J Daumann, Rüdiger Klingeler, Changhyun Koo, Mark J Riley, Asha E Roberts, Hubert Wadepohl, Johannes Werner
The electronic and magnetic properties of a set of mononuclear terbium(III) and dysprosium(III) complexes with two tetradentate 1-hydroxy-pyridin-2-one (1,2-HOPO) ligands are reported. Two primary coordination geometries are observed depending on the length of the linker between the 1,2-HOPO donor moieties and the resulting arrangements of the linker. Fine details of the magnetic circular dichroism (MCD) spectra of the dysprosium(III) complexes illustrate differences in the splitting of the J multiplets and allow for a thorough ligand field analysis...
February 6, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29403325/tafro-syndrome-current-perspectives
#18
REVIEW
Kentaro Sakashita, Kengo Murata, Mikio Takamori
Multicentric Castleman's disease (MCD), a distinct subtype of Castleman's disease, is a rare, nonneoplastic, lymphoproliferative disorder. Patients with MCD present with systemic symptoms and multiple lymphadenopathy. Lymph node biopsy is necessary for the diagnosis of various histological MCD patterns including hyaline vascular, plasma cell, and mixed types. Human herpesvirus 8 (HHV8) infection was identified as an important etiology of MCD among immunocompromised patients such as those positive for human immunodeficiency virus...
2018: Journal of Blood Medicine
https://www.readbyqxmd.com/read/29395351/end-stage-renal-disease-and-mortality-outcomes-across-different-glomerulonephropathies-in-a-large-diverse-us-population
#19
John J Sim, Simran K Bhandari, Michael Batech, Aviv Hever, Teresa N Harrison, Yu-Hsiang Shu, Dean A Kujubu, Tracy Y Jonelis, Michael H Kanter, Steven J Jacobsen
OBJECTIVE: To compare renal function decline, incident end-stage renal disease (ESRD), and mortality among patients with 5 common glomerular diseases in a large diverse population. PATIENTS AND METHODS: A retrospective cohort study (between January 1, 2000, and December 31, 2011) of patients with glomerulonephropathy using the electronic health record of an integrated health system was performed. Estimated glomerular filtration rate (eGFR) change, incident ESRD, and mortality were compared among patients with biopsy-proven focal segmental glomerulosclerosis (FSGS), membranous glomerulonephritis (MN), minimal change disease (MCD), immunoglobulin A nephropathy (IgAN), and lupus nephritis (LN)...
January 9, 2018: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29394267/environmental-enrichment-normalizes-hippocampal-timing-coding-in-a-malformed-hippocampus
#20
Amanda E Hernan, J Matthew Mahoney, Willie Curry, Greg Richard, Marcella M Lucas, Andrew Massey, Gregory L Holmes, Rod C Scott
Neurodevelopmental insults leading to malformations of cortical development (MCD) are a common cause of psychiatric disorders, learning impairments and epilepsy. In the methylazoxymethanol (MAM) model of MCDs, animals have impairments in spatial cognition that, remarkably, are improved by post-weaning environmental enrichment (EE). To establish how EE impacts network-level mechanisms of spatial cognition, hippocampal in vivo single unit recordings were performed in freely moving animals in an open arena. We took a generalized linear modeling approach to extract fine spike timing (FST) characteristics and related these to place cell fidelity used as a surrogate of spatial cognition...
2018: PloS One
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