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Michal Kielbinski, Zuzanna Setkowicz, Kinga Gzielo, Krzysztof Janeczko
Malformations of cortical development (MCD) are a common cause of intractable seizures in humans. Among these, focal cortical dysplasia (FCD) poses an outstanding challenge. There are several subtypes of FCD that show significant variation in pathology and clinical presentation. All types exhibit disturbed cortical cytoarchitecture and increased propensity for seizures. The etiology is likely heterogenous, with mutations, specifically in genes related to mammalian target of rapamycin (mTOR), identified in only a subset of cases...
April 16, 2018: Developmental Neurobiology
Benedita Maria Costa-Neta, Abdias Ribeiro Lima-Neto, Apoliana Araújo da Silva, Jefferson Mesquita Brito, João Vitor Castro Aguiar, Islana Silva Ponte, Francinaldo Soares Silva
In this study the phototactic response of anopheline mosquitoes to different luminous intensity light-emitting diodes (LEDs) was investigated. Centers for Disease Control-type light traps were changed by replacement of the incandescent lamps by 5 mm round type green (520 nm) and blue (470 nm) LEDs of different luminous intensities: green-LED traps with luminous intensities of 10,000, 15,000 and 20,000 millicandela (mcd) and the blue-LED traps with luminous intensities of 4000, 12,000 and 15,000 mcd...
April 9, 2018: Acta Tropica
Aude Jary, Valentin Leducq, Romain Palich, Adélie Gothland, Diane Descamps, Véronique Joly, Sidonie Lambert-Niclot, Corinne Amiel, Ana Canestri, Audrey Mirand, Elyanne Gault, Astrid Vabret, Marc-Antoine Valantin, Christine Katlama, Vincent Calvez, Nicolas Dupin, Jean-Philippe Spano, Anne-Geneviève Marcelin
Kaposi Sarcoma-Associated Herpesvirus (KSHV) is the etiologic agent of Kaposi's sarcoma (KS) but also in multicentric variant of Castleman disease (MCD) and primary effusion lymphoma (PEL), diseases occurring primarily in HIV-infected patients (1).….
April 11, 2018: Journal of Clinical Microbiology
Yonghong Zhang, Zhen Liu, Ranran Liu, Jie Wang, Maiqing Zheng, Qinghe Li, Huanxian Cui, Guiping Zhao, Jie Wen
Fatty liver is a widespread disease in chickens that causes a decrease in egg production and even death. The characteristics of the inherited phenotype of acquired fatty liver and the molecular mechanisms underlying it, however, are largely unknown. In the current study, fatty liver was induced in 3 breeds by a high-fat (HF) diet and a methionine choline-deficient (MCD) diet. The results showed that the dwarf Jingxing-Huang (JXH) chicken was more susceptible to fatty liver compared with the layer White Leghorns (WL) and local Beijing-You (BJY) breeds...
April 8, 2018: Genes
Celene Y L Yap, Ya-Seng Arthur Hsueh, Jonathan C Knott, David McD Taylor, Esther W Chan, David C M Kong
BACKGROUND: The combination of midazolam and droperidol has proven superior to droperidol or olanzapine monotherapy in the management of acute agitation in emergency departments (EDs). OBJECTIVE: This is the first economic analysis to evaluate the cost-benefit and cost effectiveness of the midazolam-droperidol combination compared with droperidol or olanzapine for the management of acute agitation in EDs. METHODS: This analysis used data derived from a randomised, controlled, double-blind clinical trial conducted in two metropolitan Australian EDs between October 2014 and August 2015...
July 24, 2017: PharmacoEconomics open
Joanna Beata Kowalska, Ryszard Mazurek, Michał Gąsiorek, Tomasz Zaleski
The paper provides a complex, critical assessment of heavy metal soil pollution using different indices. Pollution indices are widely considered a useful tool for the comprehensive evaluation of the degree of contamination. Moreover, they can have a great importance in the assessment of soil quality and the prediction of future ecosystem sustainability, especially in the case of farmlands. Eighteen indices previously described by several authors (Igeo , PI, EF, Cf , PIsum , PINemerow , PLI, PIave , PIVector , PIN, MEC, CSI, MERMQ, Cdeg , RI, mCd and ExF) as well as the newly published Biogeochemical Index (BGI) were compared...
April 5, 2018: Environmental Geochemistry and Health
Stephanie H Carpenter, Michael L Neidig
Detailed studies of iron speciation and mechanism in iron-catalyzed cross-coupling reactions are critical for providing the necessary fundamental insight to drive new reaction development. However, such insight is challenging to obtain due to the prevalence of mixtures of unstable, paramagnetic organoiron species that can form in this chemistry. A physical-inorganic research approach combining freeze-trapped inorganic spectroscopic studies, organometallic synthesis and GC/kinetic studies provides a powerful method for studying such systems...
December 2017: Israel Journal of Chemistry
Kresimir Rupnik, Chi Chung Lee, Yilin Hu, Markus W Ribbe, Brian J Hales
The P-cluster of the nitrogenase MoFe protein is a [ Fe8 S7 ] cluster that mediates efficient transfer of electrons to the active site for substrate reduction. Arguably the most complex homometallic FeS cluster found in nature, the biosynthetic mechanism of the P-cluster is of considerable theoretical and synthetic interest to chemists and biochemists alike. Previous studies have revealed a biphasic assembly mechanism of the two P-clusters in the MoFe protein upon incubation with Fe protein and ATP, in which the first P-cluster is formed through fast fusion of a pair of [ Fe4 S4 ]+ clusters within 5 min and the second P-cluster is formed through slow fusion of the second pair of [ Fe4 S4 ]+ clusters in a period of 2 h...
April 3, 2018: Inorganic Chemistry
Hayley H Chen, Simone E Taylor, Andrew M Harding, David McD Taylor
OBJECTIVE: To assess the accuracy of medication information sources available for adult patients presenting to the ED, compared to a best possible medication history (BPMH). METHODS: This prospective observational study was undertaken in the ED of a major tertiary-referral teaching hospital. A convenience sample of consecutive adult patients taking one or more regular medications was included. A BPMH was ascertained using patient/carer interviews, where available, and confirmed with one or more other sources...
April 2, 2018: Emergency Medicine Australasia: EMA
Shanshan Deng, Nannan Feng, Shaoguo Kang, Jianxin Zhu, Bo Yu, Jing Chen, Xiaofeng Xie
Mechanochemical degradation (MCD) is a promising eco-friendly method to dispose persistent organic pollutants (POPs). Mechanically induced free-radical attack was thought to be one of the key elements in initiating and accelerating the dechlorination and degradation of POPs. In this study, mechanochemical formation of free-radicals and their roles in the remediation of hexachlorobenzene (HCB) contaminated soil were explored using both of experimental analysis and quantum chemical calculations. It was found that chlorinated phenoxy radicals(CB-O) can be produced in the milling process and they played a vital role in the dechlorination of HCB, based on the results of electron spin-resonance (ESR) and X-ray photoelectron spectra (XPS)...
March 26, 2018: Journal of Hazardous Materials
Feng Li, Xiaomei Zhang, Yanting Guo, Yuandong Zhu, Yicun Wu, Yun Ling
Multicentric Castleman disease (MCD) is a rare nonmalignant lymphoproliferative disorder presenting systemic symptoms such as fever, night sweats, fatigue, anemia, effusions, and multifocal lymphadenopathy. The etiology of MCD has not been clarified to date. The coexistence of MCD with chronic myelomonocytic leukemia (CMML) has been rarely reported. Although the pathogenesis remains unclear, this association probably reflects an incidental and fortuitous finding rather than the alteration of a common pluripotent stem cell precursor...
2018: Case Reports in Hematology
Shruti Aggarwal, Travis Peck, Jeffrey Golen, Zeynel A Karcioglu
Macular corneal dystrophy (MCD) is a corneal stromal dystrophy which leads to progressive vision loss. MCD is an autosomal recessive condition in which there is abnormality of proteoglycan synthesis. Mutations in the carbohydrate sulphotransferase gene (CHST6) prevent normal sulfation of corneal keratan. Different immunophenotypes have been described depending on the presence of keratan sulfate in cornea and or serum. The deposition of abnormal proteoglycans leads to loss of corneal transparency and decreased vision...
March 28, 2018: Survey of Ophthalmology
Elie Cousin, Hugues Flodrops, Olivia Boyer, Julien Hogan, Mahe Ruin, Anne Couderc, Jean-Michel Goujon, Sophie Taque
Pediatric Castleman disease (CD) is an uncommon and poorly understood disorder of the lymph nodes. Renal failure has not been described in pediatric multicentric CD (MCD). We report four cases, who presented with polyadenopathy, organomegaly, edema and fluid accumulations, high blood pressure, and acute renal failure. In all cases, renal biopsy confirmed diffuse thrombotic microangiopathy. Definitive diagnosis of MCD was made by a biopsy of an affected lymph node located by computer tomography before initiation of corticosteroid therapy...
March 30, 2018: Pediatric Blood & Cancer
Anna Maria Piras, Ylenia Zambito, Susi Burgalassi, Daniela Monti, Silvia Tampucci, Eleonora Terreni, Angela Fabiano, Federica Balzano, Gloria Uccello-Barretta, Patrizia Chetoni
The ocular bioavailability of lipophilic drugs, such as dexamethasone, depends on both drug water solubility and mucoadhesion/permeation. Cyclodextrins and chitosan are frequently employed to either improve drug solubility or prolong drug contact onto mucosae, respectively. Although the covalent conjugation of cyclodextrin and chitosan brings to mucoadhesive drug complexes, their water solubility is restricted to acidic pHs. This paper describes a straightforward grafting of methyl-β-cyclodextrin (MCD) on quaternary ammonium chitosan (QA-Ch60), mediated by hexamethylene diisocyanate...
March 30, 2018: Journal of Materials Science. Materials in Medicine
Irshad Sirwal, Ibrahim Masoodi
BACKGROUND: There is a paucity of data on the spectrum of renal diseases prevalent in the Jammu and Kashmir region. OBJECTIVES: To determine the spectrum of glomerulopathies in adult patients attending a tertiary care centre. METHODS: Two hundred and twenty-one adequate biopsies from native kidneys of adult patients who presented with features suggestive of glomerular diseases at Sheri Kashmir Institute of medical sciences Srinagar Kashmir for the last 8 years were studied in a retrospective manner...
March 29, 2018: Nephron
Claudia Wolff, Athanasios T Vafeidis, Sanne Muis, Daniel Lincke, Alessio Satta, Piero Lionello, Jose A Jimenez, Dario Conte, Jochen Hinkel
We have developed a new coastal database for the Mediterranean basin that is intended for coastal impact and adaptation assessment to sea-level rise and associated hazards on a regional scale. The data structure of the database relies on a linear representation of the coast with associated spatial assessment units. Using information on coastal morphology, human settlements and administrative boundaries, we have divided the Mediterranean coast into 13 900 coastal assessment units. To these units we have spatially attributed 160 parameters on the characteristics of the natural and socio-economic subsystems, such as extreme sea levels, vertical land movement and number of people exposed to sea-level rise and extreme sea levels...
March 27, 2018: Scientific Data
Dan Yang, Xuan Zhou, Youcai Zhao, Shibin Cao, Ailing Su, Xuezhong Zhang, Yanli Xu, Xiuqun Zhang
Multicentric Castleman's disease (MCD) is a rare kind of lymphoproliferative disorder characterized by systemic problems such as frequent fever, fatigue and weight loss with angiofollicular lymph node hyperplasia. However, unlike unicentric Castleman's disease (UCD) with long-time survival by surgery and local radiotherapy, MCD remains poor prognosis due to no well-defined optimal treatment strategies and high risk of developing malignances especially lymphoma. We reported a case of MCD who received chemotherapy by ECHOP with unsatisfactory outcome and then oral administration with thalidomide combined with prednisone without disease progression after therapy...
March 26, 2018: Cancer Biology & Therapy
Chen Ling, Xiaorong Liu, Ying Shen, Zhi Chen, Jianfeng Fan, Yeping Jiang, Qun Meng
BACKGROUND: The level of urinary cluster of differentiation 80 (uCD80) is elevated in most children with minimal change disease (MCD) as opposed to focal segmental glomerulosclerosis (FSGS) during the acute phase. The objective of this follow-up study was to evaluate whether uCD80 elevation is actually associated with MCD and whether it signals better prognosis. METHODS: We evaluated uCD80 levels and a series of putative progression factors in a cohort of 64 patients with nephrotic syndrome (NS) seen between 2011 and 2016...
March 22, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Kento Ueta, Masaya Fukuda, Gakhyun Kim, Soji Shimizu, Takayuki Tanaka, Dongho Kim, Atsuhiro Osuka
The first Si(IV) corrole complexes were synthesized in good yields, for the first time, by treatment of meso-triarylcorroles with tetrachlorosilane in 1,2-dichloroethane at 60 °C. The central silicon atom possesses a square-pyramidal coordination geometry with slightly longer Si-N bond lengths as compared with those of known triazacorrole Si(IV) complexes. The Si(IV) corrole complexes exhibit sharp and blue-shifted absorption spectra and larger fluorescence quantum yields as compared with the corresponding freebase corroles...
March 22, 2018: Chemistry: a European Journal
Shuying He, Weihong Guo, Feihong Deng, Kequan Chen, Yonghong Jiang, Minyu Dong, Liang Peng, Xueqing Chen
Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases worldwide, and precision therapeutic will be a benefit for the NAFLD regression. In this study, we observed low microRNA 146 b (miR-146 b) expression in NAFLD mice model induced by methionine-choline-deficient diet (MCD) compared with control group. Furthermore, miR-146b-/- mice induced MCD exhibited severe liver steatosis and hepatitis. A bio-distribution study showed that novel Lactosylated PDMAEMA nanoparticles effectively targeted hepatocytes Lac-PDMAEMA...
March 21, 2018: Artificial Cells, Nanomedicine, and Biotechnology
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