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Peritonal Dialysis

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https://www.readbyqxmd.com/read/29793213/end-stage-renal-disease-models-in-the-americas-optimizing-resources-to-achieve-better-health-outcomes
#1
Ramiro E Gilardino, Eduardo González-Pier, Claudia Brabata
End-stage renal disease, the last and most severe stage of chronic kidney disease, represents a major and rising concern for countries in Latin America, driven in large part by aging populations and the near-epidemic rises in diabetes, obesity, and hypertension. This places a great clinical, economic, and social burden on the region's health systems. During the ISPOR 6th Latin America Conference held in Sao Paulo, Brazil, in September 2017, an educational forum debated on value-based decision making in the treatment of end-stage renal disease in Latin America...
May 21, 2018: Value in Health Regional Issues
https://www.readbyqxmd.com/read/29792163/different-patterns-of-inflammatory-and-angiogenic-factors-are-associated-with-peritoneal-small-solute-transport-and-peritoneal-protein-clearance-in-peritoneal-dialysis-patients
#2
Yuanyuan Shi, Hao Yan, Jiangzi Yuan, He Zhang, Jiaying Huang, Zhaohui Ni, Jiaqi Qian, Wei Fang
BACKGROUND: Both peritoneal small solute transport and peritoneal protein clearance are closely linked to outcomes in peritoneal dialysis (PD) patients. However, the associated factors of these two components are not fully understood so far. This study aimed to investigate the association between a panel of systemic and peritoneal inflammatory and angiogenic factors and peritoneal solute transport properties. METHODS: Stable PD patients in PD center of Renji Hospital, School of Medicine, Shanghai Jiao Tong University were enrolled in present study...
May 23, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29787614/outcome-of-polycystic-kidney-disease-patients-on-peritoneal-dialysis-systematic-review-of-literature-and-meta-analysis
#3
Vincent Dupont, Lukshe Kanagaratnam, Mickaël Sigogne, Clémence Bechade, Thierry Lobbedez, Jose Portoles, Philippe Rieu, Moustapha Drame, Fatouma Touré
BACKGROUND: Polycystic kidney disease (PKD) is the most frequent hereditary cause of chronic kidney disease. Peritoneal dialysis (PD) is often avoided for patients with PKD because of the suspected risk of mechanical and infectious complications. Only a few studies have analyzed the outcome of PKD patients on PD with sometimes conflicting results. The purpose of this meta-analysis was to investigate outcomes of patients with PKD treated by PD. METHODS: A systematic review and meta-analysis were performed examining all studies which included "Polycystic kidney disease" and "Peritoneal dialysis" in their titles, excluding commentaries, letters to the authors and abstracts...
2018: PloS One
https://www.readbyqxmd.com/read/29780074/communication-site-ligation-and-polyglycolic-acid-sheet-use-for-the-treatment-of-hydrothorax-in-patients-undergoing-continuous-ambulatory-peritoneal-dialysis
#4
Hirotoshi Kubokura, Junichi Okamoto, Jitsuo Usuda
INTRODUCTION: Hydrothorax due to pleuroperitoneal communication (PPC) can occur in patients undergoing continuous ambulatory peritoneal dialysis (CAPD). We report our experiences of the safety and efficacy of the treatment of four patients with a novel video-assisted thoracoscopy method. METHODS: Single-port video-assisted thoracoscopic surgery (VATS) was performed with a mini-thoracotomy of 5 cm in length. The PPC site was identified on the diaphragm and ligated using an endoscopic loop...
May 21, 2018: Annals of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29779821/clinical-efficacy-and-feasibility-of-whey-protein-isolates-supplementation-in-malnourished-peritoneal-dialysis-patients-a-multicenter-parallel-open-label-randomized-controlled-trial
#5
Sharmela Sahathevan, Chee-Hee Se, SeeHoe Ng, Ban-Hock Khor, Karuthan Chinna, Bak Leong Goh, Halim A Gafor, Sunita Bavanandan, Ghazali Ahmad, Tilakavati Karupaiah
BACKGROUND AND AIMS: Poor dietary intake is commonly associated with malnutrition in the dialysis population and oral nutritional supplementation is strategized to redress dietary inadequacy. Knowledge on clinical efficacy of whey protein supplementation (WPS) as an option to treat malnutrition in continuous ambulatory peritoneal dialysis (CAPD) patients is limited. METHODS: This multicenter, parallel, open-label, randomized controlled trial investigated the clinical efficacy of WPS in 126 malnourished CAPD patients with serum albumin <40 g/L and body mass index (BMI) <24 kg/m2 ...
June 2018: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29779501/marine-n-3-pufa-heart-rate-variability-and-ventricular-arrhythmias-in-patients-on-chronic-dialysis-a-cross-sectional-study
#6
Jesper M Rantanen, Erik B Schmidt, Sam Riahi, Søren Lundbye-Christensen, Jeppe H Christensen
Marine n-3 PUFA may improve autonomic dysfunction by an increase in heart rate variability (HRV) and may reduce the risk of malignant ventricular arrhythmias. Only a few smaller studies have examined such effects in patients on chronic dialysis, who often have autonomic dysfunction and a high risk of sudden cardiac death, which accounts for almost 30 % of all deaths. This cross-sectional study investigated the association between the plasma phospholipid content of n-3 PUFA and 24-h HRV or ventricular arrhythmias in patients on chronic dialysis...
May 21, 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29779030/high-intraperitoneal-interleukin-6-levels-predict-peritonitis-in-peritoneal-dialysis-patients-a-prospective-cohort-study
#7
Xiaoxiao Yang, Yijing Tong, Hao Yan, Zhaohui Ni, Jiaoqi Qian, Wei Fang
BACKGROUND: To evaluate the predictive value of dialysate interleukin-6 (IL-6) representing local subclinical intraperitoneal inflammation for the development of peritonitis in continuous ambulatory peritoneal dialysis (CAPD) patients. METHODS: Stable prevalent CAPD patients were enrolled in this prospective study. IL-6 concentration in the overnight effluent was determined and expressed as the IL-6 appearance rate (IL-6AR). Patients were divided into 2 groups according to the median of IL-6AR and prospectively followed up until the first episode of peritonitis, cessation of PD, or the end of the study (December 30, 2017)...
May 18, 2018: American Journal of Nephrology
https://www.readbyqxmd.com/read/29776936/ethambutol-and-isoniazid-induced-severe-neurotoxicity-in-a-patient-undergoing-continuous-ambulatory-peritoneal-dialysis
#8
Meijun Si, Huiqun Li, Yanru Chen, Hui Peng
Ethambutol (EMB) and isoniazid (INH) are the first-line antituberculosis (anti-TB) drugs. However, their neurotoxicity could cause adverse effect and the patients with end-stage renal disease are especially vulnerable due to the reduction in renal drug clearance. Here, we report a 36-year-old man receiving peritoneal dialysis developed progressive paralysis in lower extremities, vision loss and hoarseness 4 months after anti-TB treatment with INH, EMB and rifapentine because of concomitant pulmonary tuberculosis...
May 18, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29776755/neutral-ph-and-low-glucose-degradation-product-dialysis-fluids-induce-major-early-alterations-of-the-peritoneal-membrane-in-children-on-peritoneal-dialysis
#9
Betti Schaefer, Maria Bartosova, Stephan Macher-Goeppinger, Peter Sallay, Peter Vörös, Bruno Ranchin, Karel Vondrak, Gema Ariceta, Ariane Zaloszyc, Aysun K Bayazit, Uwe Querfeld, Rimante Cerkauskiene, Sara Testa, Christina Taylan, Johan VandeWalle, YokChin Yap, Rafael T Krmar, Rainer Büscher, Anne K Mühlig, Dorota Drozdz, Salim Caliskan, Felix Lasitschka, Sahar Fathallah-Shaykh, Enrico Verrina, Günter Klaus, Klaus Arbeiter, Raj Bhayadia, Anette Melk, Philipp Romero, Bradley A Warady, Franz Schaefer, Akos Ujszaszi, Claus Peter Schmitt
The effect of peritoneal dialysates with low-glucose degradation products on peritoneal membrane morphology is largely unknown, with functional relevancy predominantly derived from experimental studies. To investigate this, we performed automated quantitative histomorphometry and molecular analyses on 256 standardized peritoneal and 172 omental specimens from 56 children with normal renal function, 90 children with end-stage kidney disease at time of catheter insertion, and 82 children undergoing peritoneal dialysis using dialysates with low-glucose degradation products...
May 15, 2018: Kidney International
https://www.readbyqxmd.com/read/29776362/apolipoprotein-b-apolipoprotein-a1-ratio-and-mortality-among-incident-peritoneal-dialysis-patients
#10
Xiaojiang Zhan, Yanbing Chen, Caixia Yan, Siyi Liu, Lijuan Deng, Yuting Yang, Panlin Qiu, Dan Pan, Bingxiang Zeng, Qinkai Chen
BACKGROUND: To investigate the association between the ratio of apolipoprotein B (apo B) / apolipoprotein A1 (apo A1) with all-cause mortality and cardiovascular events in peritoneal dialysis (PD) patients. METHODS: Eight hundred and sixty incident PD patients were enrolled from November 1, 2005, to February 28, 2017, and followed until May 31, 2017. Outcomes were all-cause mortality and cardiovascular events. Associations between the apo B/apo A1 ratio with all-cause mortality and cardiovascular events were evaluated using multivariable-adjusted Cox models...
May 17, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29775233/dialysis-modality-and-mortality-in-polycystic-kidney-disease
#11
Chenchen Zhou, Yaodong Gu, Changlin Mei, Bing Dai, Yi Wang, Cheng Xue
INTRODUCTION: Identifying the appropriate modality between hemodialysis (HD) and peritoneal dialysis (PD) is an unresolved issue in polycystic kidney disease (PKD) patients. This study aims to illustrate whether the mortality and survival are different among individuals receiving HD comparing PD. METHODS: We searched PubMed, EMBASE, and China National Knowledge Infrastructure about cohort studies involving PKD patients with end stage renal disease and comparing HD with PD...
May 18, 2018: Hemodialysis International
https://www.readbyqxmd.com/read/29774544/functional-molecules-in-mesothelial-to-mesenchymal-transition-revealed-by-transcriptome-analyses
#12
Sara Namvar, Adrian S Woolf, Leo A H Zeef, Thomas Wilm, Bettina Wilm, Sarah E Herrick
Peritoneal fibrosis is a common complication of abdominal and pelvic surgery, and can also be triggered by peritoneal dialysis, resulting in treatment failure. In these settings, fibrosis is driven by activated myofibroblasts that are considered to be partly derived by mesothelial-to-mesenchymal transition (MMT). We hypothesised that if the molecular signature of MMT could be better defined, these insights could be exploited to block this pathological cellular transition. Rat peritoneal mesothelial cells were purified, using an antibody to HBME1, a protein present on mesothelial cell microvilli, and streptavidin nanobead technology...
May 17, 2018: Journal of Pathology
https://www.readbyqxmd.com/read/29768353/correlation-of-increased-th17-treg-cell-ratio-with-endoplasmic-reticulum-stress-in-chronic-kidney-disease
#13
Xiaojing Zhu, Shuiqin Li, Qiaona Zhang, Dan Zhu, Yang Xu, Pengqian Zhang, Jin Han, Zhaoyang Duan, Jie Gao, Yan Ou
To investigate the relationship between the regulatory immune network and endoplasmic reticulum stress (ERS) in patients with different stages of chronic kidney disease (CKD).A total of 91 patients diagnosed with CKD were divided into different groups according to the stage of disease and treatment with hemodialysis (HD) or peritoneal dialysis (PD). Routine blood and biochemical tests were performed in patients in the different CKD groups and in healthy controls (n = 20). The frequencies of T helper type 17 (Th17) and regulatory T (Treg) cells in the overall T cell population were measured by flow cytometric analysis...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29767390/safety-and-efficacy-of-endoscopic-retrograde-cholangiopancreatography-for-choledocholithiasis-in-long-term-dialysis-a-propensity-score-analysis
#14
Sung Bum Kim, Kook Hyun Kim, Tae Nyeun Kim
BACKGROUND AND AIM: Previous studies evaluating the safety of endoscopic retrograde cholangiopancreatography (ERCP) in patients with end-stage renal disease (ESRD) undergoing hemodialysis reported an increased risk of post-procedural bleeding. We investigated the safety and efficacy of ERCP for the treatment of choledocholithiasis in patients with ESRD undergoing long-term dialysis. METHODS: A total of 3466 patients who underwent ERCP due to choledocholithiasis between January 2000 and Feb 2018 were reviewed and analyzed retrospectively...
May 16, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29762845/peritoneal-dialysis-effectively-removes-toxic-substances-and-improves-liver-functions-of-liver-failure-patients
#15
W-X Zhao, X-M Liu, C-M Yu, H Xu, J-R Dai, H-Y Chen, L Li, F Chen, Y-L Ou, Z-K Zhao
OBJECTIVE: Liver failure (LF) is a clinically complex disorder that characterizes with hepatic dysfunction. This study aimed at observing the therapeutic effects of peritoneal dialysis on liver function in LF patients. PATIENTS AND METHODS: This study involves 62 patients diagnosed as LF hospitalized from February 2005 to December 2016. The 62 LF patients were randomly divided into 3 groups, including artificial liver applying plasma exchange group (PE, n = 28), peritoneal dialysis group (PD, n = 22), and conservative treatment group (CT, n=12)...
April 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29760854/peritoneal-dialysis-in-austere-environments-an-emergent-approach-to-renal-failure-management
#16
REVIEW
Chad Gorbatkin, John Bass, Fredric O Finkelstein, Steven M Gorbatkin
Peritoneal dialysis (PD) is a means of renal replacement therapy (RRT) that can be performed in remote settings with limited resources, including regions that lack electrical power. PD is a mainstay of end-stage renal disease (ESRD) therapy worldwide, and the ease of initiation and maintenance has enabled it to flourish in both resource-limited and resource-abundant settings. In natural disaster scenarios, military conflicts, and other austere areas, PD may be the only available life-saving measure for acute kidney injury (AKI) or ESRD...
May 2018: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29759796/factors-associated-with-anthropometric-indicators-of-nutritional-status-in-children-with-chronic-kidney-disease-undergoing-peritoneal-dialysis-hemodialysis-and-after-kidney-transplant
#17
Julieta García De Alba Verduzco, Erika Fabiola Hurtado López, Consuelo Pontón Vázquez, Adriana de la Torre Serrano, Enrique Romero Velarde, Edgar Manuel Vásquez Garibay
OBJECTIVE: The objective of the study was to demonstrate that there are differences in the factors associated with anthropometric indicators of nutritional status, with particular emphasis on arm indicators, in children with end-stage kidney disease undergoing peritoneal dialysis (PD), hemodialysis (HD), and after kidney transplant (KT). METHODS: An analytical cross-sectional study of consecutive cases included 130 children and adolescents with end-stage kidney disease undergoing substitutive treatment: 49 patients who underwent KT, 33 undergoing PD, and 47 undergoing HD...
May 11, 2018: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/29753403/clinical-studies-of-interventions-to-mitigate-cardiovascular-risk-in-peritoneal-dialysis-patients
#18
REVIEW
Dev Jegatheesan, Yeoungjee Cho, David W Johnson
Cardiovascular disease (CVD) is highly prevalent in the peritoneal dialysis (PD) population, affecting up to 60% of cohorts. CVD is the primary cause of death in up to 40% of PD patients in Australia, New Zealand, and the United States. Cardiovascular mortality rates are reported to be approximately 14 per 100 patient-years, which are 10- to 20-fold greater than those of age- and sex-matched controls. The excess risk of CVD is related to a combination of traditional risk factors (such as hypertension, dyslipidemia, obesity, smoking, sedentary lifestyle, and insulin resistance), nontraditional (kidney disease-related) risk factors (such as anemia, chronic volume overload, inflammation, malnutrition, hyperuricemia, and mineral and bone disorder), and PD-specific risk factors (such as dialysis solutions, glycation end products, hypokalemia, residual kidney function, and ultrafiltration failure)...
May 2018: Seminars in Nephrology
https://www.readbyqxmd.com/read/29753311/peritoneal-and-systemic-responses-of-obese-type-ii-diabetic-rats-to-chronic-exposure-to-a-hyperbranched-polyglycerol-based-dialysis-solution
#19
Bo La Han, Qiunong Guan, Irina Chafeeva, Asher A Mendelson, Gerald da Roza, Richard Liggins, Jayachandran N Kizhakkedathu, Caigan Du
Metabolic syndrome (MetS) is commonly observed among peritoneal dialysis (PD) patients, and hyperbranched polyglycerol (HPG) is a promising glucose-sparing osmotic agent for PD. However, the biocompatibility of a HPG-based PD solution (HPG) in subjects with MetS has not been investigated. This study compared the local and systemic effects of a HPG solution with conventional Physioneal (PYS) and Icodextrin (ICO) PD solutions in rats with MetS. Obese type 2 diabetic ZSF1 rats received a daily intraperitoneal injection of PD solutions (10 mL) for 3 months...
May 12, 2018: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29746497/peritoneal-dialysis-related-peritonitis-caused-by-pseudomonas-species-insight-from-a-post-millennial-case-series
#20
Wanhong Lu, Bonnie Ching-Ha Kwan, Kai Ming Chow, Wing-Fai Pang, Chi Bon Leung, Philip Kam-To Li, Cheuk Chun Szeto
BACKGROUND: Pseudomonas peritonitis is a serious complication of peritoneal dialysis (PD). However, the clinical course of Pseudomonas peritonitis following the adoption of international guidelines remains unclear. METHODS: We reviewed the clinical course and treatment response of 153 consecutive episodes of PD peritonitis caused by Pseudomonas species from 2001 to 2015. RESULTS: Pseudomonas peritonitis accounted for 8.3% of all peritonitis episodes...
2018: PloS One
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