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Skin rejuvenation

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https://www.readbyqxmd.com/read/28403273/the-mechanisms-and-potential-impact-of-stem-cell-activation-in-skin-rejuvenation-an-evidence-based-analysis
#1
Hema Sundaram
<p>Stem cells can propagate indefinitely in an undifferentiated state; or, with appropriate signals, differentiate into various types of mature cells. Strong interest in stem cell therapies for degenerative diseases has extended to skin aging, itself a degenerative process. This article reviews mechanisms of skin aging, and enables an evidence-based approach to topical skin rejuvenation - specifically, to formulations labeled as stem cell products.</p> <p><em>J Drugs Dermatol. 2017;16(4):378-384...
April 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28403263/microneedling-in-all-skin-types-a-review
#2
Lauren Meshkov Bonati, Gorana Kuka Epstein, Tamara Lazic Strugar
<p>INTRODUCTION: Microneedling procedures are growing in popularity for a wide variety of skin conditions. This paper comprehensively reviews the medical literature regarding skin needling efficacy and safety in all skin types and in multiple dermatologic conditions.</p> <p>METHODS: A PubMed literature search was conducted in all languages without restriction and bibliographies of relevant articles reviewed. Search terms included: "microneedling," "percutaneous collagen induction," "needling," "skin needling," and "dermaroller...
April 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28389776/senotherapy-growing-old-and-staying-young
#3
REVIEW
Roland Schmitt
Cellular senescence, which has been linked to age-related diseases, occurs during normal aging or as a result of pathological cell stress. Due to their incapacity to proliferate, senescent cells cannot contribute to normal tissue maintenance and tissue repair. Instead, senescent cells disturb the microenvironment by secreting a plethora of bioactive factors that may lead to inflammation, regenerative dysfunction and tumor progression. Recent understanding of stimuli and pathways that induce and maintain cellular senescence offers the possibility to selectively eliminate senescent cells...
April 7, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28382785/autologous-platelet-rich-plasma-versus-readymade-growth-factors-in-skin-rejuvenation-a-split-face-study
#4
Heba I Gawdat, Amira M Tawdy, Rehab A Hegazy, Mohga M Zakaria, Ryham S Allam
BACKGROUND: The escalating urge for a youthful-looking skin instigates continuous innovations with minimally invasive procedures. Readymade growth factors and autologous platelet-rich plasma (PRP) represent such therapeutic interventions. OBJECTIVE: Compare the efficacy and safety of PRP to readymade growth factors in skin rejuvenation. PATIENTS AND METHODS: Twenty adult females with Fitzpatrick skin types III-IV and Glogau photoaging types II and III were enrolled in this study...
April 5, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28375975/autologous-pure-platelet-rich-plasma-dermal-injections-for-facial-skin-rejuvenation-clinical-instrumental-and-flow-cytometry-assessment
#5
Norma Cameli, Maria Mariano, Iole Cordone, Elva Abril, Serena Masi, Maria Laura Foddai
BACKGROUND: Platelet-rich plasma (PRP) is an emerging treatment in dermatology recently proposed for skin rejuvenation. OBJECTIVE: To evaluate the efficacy and safety of autologous pure PRP dermal injections on facial skin rejuvenation, investigating the cellularity of PRP samples. MATERIALS AND METHODS: Twelve patients underwent 3 sessions of PRP injection at 1-month intervals. The clinical and instrumental outcomes were evaluated before (T0) and 1 month (T1) after the end of treatment by means of transepidermal water loss, corneometry, Cutometer, Visioscan, and Visioface...
April 3, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28373880/effects-of-multipolar-radiofrequency-and-pulsed-electromagnetic-field-treatment-for-face-and-neck-rejuvenation
#6
Thais Cristina Ferraz de Oliveira, Sheyla de Fatima Soares Rocha, Daniel Gontijo Ramos, Camila Gontijo Ramos, Michelle Vanessa Dos Anjos Carvalho, Mariana Gontijo Ramos
Skin aging is a gradual process that leads to wrinkle formation, laxity, and overall changes in skin appearance. In recent years, the demands to noninvasive treatments for facial rejuvenation increased, along with a variety of technologies and devices, such as radiofrequency. The present study aimed to evaluate the clinical effects of a multipolar radiofrequency and pulsed electromagnetic field treatment for face and neck rejuvenation. Eleven patients with mild to moderate grades of photoaging underwent eight radiofrequency and pulsed electromagnetic field treatment sessions, once a week...
2017: Dermatology Research and Practice
https://www.readbyqxmd.com/read/28367263/melasma-associated-with-topical-estrogen-cream
#7
Alyson Snyder, Rachel A Schiechert, Martin N Zaiac
A 47-year-old woman presented with hyperpigmented patches on her upper extremities. The patient had begun using a topical estrogen cream in the affected areas prior to noticing the hyperpigmentation. A diagnosis of melasma secondary to topical estrogen cream was made. While systemic hormones are a well-documented trigger for the development of melasma, this case represents the first report of melasma associated with topical estrogens. Topical estrogens are frequently prescribed to postmenopausal women for skin rejuvenation...
February 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/28359075/a-holistic-approach-to-antiaging-as-an-adjunct-to-antiaging-procedures-a-review-of-the-literature
#8
Sandeep S Saluja, Sabrina G Fabi
BACKGROUND: Aging is a multifactorial process and depends on both intrinsic and extrinsic factors. Procedural options for diminishing signs of intrinsic aging and cosmetic rejuvenation have expanded dramatically. However, less attention is paid to counseling patients on options for mitigating extrinsic factors related to aging. OBJECTIVE: The objective of this study was to review changes that occur with intrinsic and extrinsic aging, and provide evidence-based holistic counseling recommendations that can be used synergistically with aesthetic procedures to maximize antiaging interventions...
April 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28343910/anti-skin-aging-effect-of-epigallocatechin-gallate-by-regulating-epidermal-growth-factor-receptor-pathway-on-aging-mouse-model-induced-by-d-galactose
#9
Jiming Chen, Yifan Li, Qiangqiang Zhu, Tong Li, Hao Lu, Nan Wei, Yewei Huang, Ruoyu Shi, Xiao Ma, Xuanjun Wang, Jun Sheng
Epigallocatechin gallate(EGCG) is a monomer separated from tea catechins, as an well-known antioxidant, which helps fight wrinkles and rejuvenate skin cells. In this study, we investigated the anti-aging effect of EGCG, and to clarify underlying mechanism of skin aging in a d-galactose-induced aging mouse model. Forty-five male mice were divided into 5 groups and treated with different dose of EGCG, Vitamin C (VitC) to mice as a positive control. All groups except vehicle were established aging model induced by d-galactose (200mg/kg/day) that was subcutaneously injected to mice for 8 weeks...
March 24, 2017: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/28299489/a-split-face-comparison-of-q-switched-nd-yag-1064-nm-laser-for-facial-rejuvenation-in-nevus-of-ota-patients
#10
Cao Yongqian, Lin Li, Bi Jianhai, Huo Ran, Guo Li, Wei Hao, Wang Xining, Xie Shigang, Wang Yibing
We aimed to investigate the efficacy and safety of using the 1064-nm Q-switched neodymium-doped yttrium aluminum garnet (Nd:YAG) laser (QSNYL) for skin rejuvenation in patients with Nevus of Ota. A retrospective, randomized, split-faced, clinical study was conducted. Twenty-nine patients with unilateral moderate to severe Nevus of Ota were enrolled. The participants completed 3-13 sessions of QSNYL treatments 3-6 months apart. Two independent physicians compared the treated and untreated sides of the face to evaluate the clearance of Nevus of Ota, the wrinkle severity rating scale (WSRS), the global aesthetic improvement scale (GAIS), and adverse event reporting...
March 15, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28245638/impact-of-age-and-insulin-like-growth-factor-1-on-dna-damage-responses-in-uv-irradiated-human-skin
#11
REVIEW
Michael G Kemp, Dan F Spandau, Jeffrey B Travers
The growing incidence of non-melanoma skin cancer (NMSC) necessitates a thorough understanding of its primary risk factors, which include exposure to ultraviolet (UV) wavelengths of sunlight and age. Whereas UV radiation (UVR) has long been known to generate photoproducts in genomic DNA that promote genetic mutations that drive skin carcinogenesis, the mechanism by which age contributes to disease pathogenesis is less understood and has not been sufficiently studied. In this review, we highlight studies that have considered age as a variable in examining DNA damage responses in UV-irradiated skin and then discuss emerging evidence that the reduced production of insulin-like growth factor-1 (IGF-1) by senescent fibroblasts in the dermis of geriatric skin creates an environment that negatively impacts how epidermal keratinocytes respond to UVR-induced DNA damage...
February 26, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28244901/new-classification-system-for-tear-trough-deformity
#12
Mohammed G Turkmani
BACKGROUND: Tear trough deformities (TTD) refer to a set of conditions leading to different shapes in the junction between the lower eyelid and the cheek. Tear trough deformity is a major aesthetic concern for a lot of individuals seeking periorbital rejuvenation and is one of the most discussed landmarks in facial aesthetic surgery. OBJECTIVE: To describe a new morphologically related classification system, providing an objective means to evaluating the deformity...
February 27, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28229524/dermal-morphological-changes-following-salicylic-acid-peeling-and-microdermabrasion
#13
Amira A Abdel-Motaleb, Eman E Abu-Dief, Mahmoud Ra Hussein
BACKGROUND: Microdermabrasion and chemical peeling are popular, inexpensive, and safe methods for treatment of some skin disorders and to rejuvenate skin. OBJECTIVES: To study the alterations of the dermal connective tissue following salicylic acid peeling and microdermabrasion. METHODS: Twenty patients were participated in our study. All participants underwent facial salicylic acid 30% peel or microdermabrasion (10 cases in each group) weekly for 6 weeks...
February 22, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28215619/the-effect-of-aging-on-the-three-dimensional-aspect-of-the-hand-a-pilot-study
#14
I A Hoevenaren, T S Wesselius, J W Meulstee, R D Vreeken, T J J Maal, D J O Ulrich
BACKGROUND: With the increasing popularity of rejuvenation treatments of the skin, there has been an increase in patient inquiry for rejuvenation of the hand. Thus far, no imaging tool exists to analyze the aging process of the hand. Three-dimensional (3D) stereophotogrammetry is a reliable technique, which is used for other purposes in soft tissue analysis of the upper extremity. This pilot study aimed to investigate the possibility of visualizing the hand aging process by 3D stereophotogrammetry...
April 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28198772/micro-free-orbital-fat-grafts-to-the-tear-trough-deformity-during-lower-blepharoplasty
#15
Suzette G Miranda, Mark A Codner
BACKGROUND: The tear trough deformity is challenging in lower eyelid rejuvenation. Surgical treatment has evolved with more modern techniques preserving orbital fat and using autologous fat transposition. The author reviewed his own experience in targeting the tear trough in lower lid blepharoplasty and presented a new technique that incorporates the addition of micro free fat grafts which adds direct volume to the underlying anatomical depression using a transcutaneous skin-muscle approach...
February 13, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28169910/long-term-outcome-of-microautologous-fat-transplantation-to-correct-temporal-depression
#16
Su-Shin Lee, Yu-Hao Huang, Tsung-Yin Lin, Chih-Kang Chou, Hidenobu Takahashi, Chung-Sheng Lai, Sin-Daw Lin, Tsai-Ming Lin
OBJECTIVE: Sunken temporal fossa appears oftentimes in Asians and resembles bad fortune that people wish to change. Numerous techniques and materials have been applied clinically for augmenting the sunken temporal fossa with variable results. The microautologous fat transplantation (MAFT) technique proposed by Lin et al in 2006 has demonstrated favorable results in facial rejuvenation. In the present study, the authors applied the MAFT technique with an innovative instrument in sunken temporal fossa and reported its results...
February 6, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28152387/development-of-an-enzyme-linked-immunosorbent-assay-for-the-detection-of-isomiroestrol-an-identical-marker-in-white-kwao-krua-using-a-monoclonal-antibody
#17
Tharita Kitisripanya, Kamonthip Jutathis, Chadathorn Inyai, Jukrapun Komaikul, Orapin Udomsin, Hiroyuki Tanaka, Waraporn Putalun
Pueraria candollei var. mirifica or White Kwao Krua (WKK) is a phytoestrogen-rich plant widely used among women to improve climacteric symptoms. Additionally, the tuberous roots of this plant have been added as an active ingredient for skin rejuvenation and breast enlargement effects in various functional foods. However, most of the products on the market containing WKK have not been sufficiently standardized with respect to the active compound or identical marker. To control the quality of these plant materials, an enzyme-linked immunosorbent assay (ELISA) using anti-isomiroestrol antibodies was established for the determination of isomiroestrol, an identical marker in WKK...
January 23, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28150435/study-of-efficacy-of-esthetic-high-intensity-focused-ultrasound-system-on-iranian-skin-for-reducing-the-laxity-and-wrinkles-of-aging
#18
Parvaneh Saket, Shobeir Shobeihi, Soroush Mehrdadi
BACKGROUND: Ultrasound is a mechanical wave that transmitted in a straight line and it can be focused at frequencies of 1-7 MHz with a high degree of precision. An important aspect of HIFU is that damaging focal point is located several millimeters below the surface of the skin and tissue above and below the focal point remains unaffected. Due to absorption of this energy, temperature of tissue rises to more than 60°C and this stimulates the cells for collagen production and tissue rejuvenation...
February 2, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28135887/median-canaliform-nail-dystrophy-treated-with-a-1064-nm-q-switched-nd-yag-laser
#19
Ju-Yeon Choi, Hyun-Min Seo, Won-Serk Kim
Median canaliform nail dystrophy is an uncommon and idiopathic dystrophic change, typically appears as central, longitudinal groove or split involving one or both thumbnails. Various treatments including potent topical steroid, an intralesional injection of triamcinolone 2.5 to 3 mg/dL, medications for systemic treatment, and topical psoralen plus ultraviolet A (PUVA) have been tried to treat the disease. However, each treatment has limitations including severe pain, inconsistent treatment results, long treatment periods, and dissatisfaction with effects of treatment...
January 31, 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/28121859/treatment-of-anterior-neck-aging-without-a-submental-approach-lateral-skin-platysma-displacement-a-new-and-proven-technique-for-platysma-bands-and-skin-laxity
#20
Mario Pelle-Ceravolo, Matteo Angelini, Erminia Silvi
BACKGROUND: A high rate of recurrence of anterior platysma bands and anterior skin laxity was reported at the 1-year follow-up of 150 patients who underwent complete neck undermining and full-width platysma transection for neck rejuvenation. The authors propose a new technique-lateral skin-platysma displacement-to treat these two aesthetic problems using only a lateral approach to avoid "opening" the anterior neck. The authors' objective was to compare outcomes following full-width platysma transection technique and lateral skin-platysma displacement technique in terms of patient satisfaction, complications, and long-term effectiveness in the treatment of bands and anterior skin laxity...
February 2017: Plastic and Reconstructive Surgery
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