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https://www.readbyqxmd.com/read/28629885/-prevalence-of-osteoporosis-estimation-of-probability-of-fracture-and-bone-metabolism-study-in-patients-with-newly-diagnosed-prostate-cancer-in-the-health-area-of-lugo
#1
Jonatan Miguel-Carrera, Carlos García-Porrua, Francisco Javier de Toro Santos, Jose Antonio Picallo-Sánchez
OBJECTIVE: To study the prevalence of osteoporosis and fracture probability in patients diagnosed with prostate cancer. DESIGN: Observational descriptive transversal study. SITE: Study performed from Primary Care of Lugo in collaboration with Rheumatology and Urology Services of our referral hospital. PARTICIPANTS: Patients diagnosed with prostate cancer without bone metastatic disease from January to December 2012. MAIN MEASUREMENTS: Epidemiologic, clinical, laboratory and densitometric variables involved in osteoporosis were collected...
June 16, 2017: Atencion Primaria
https://www.readbyqxmd.com/read/28626628/assessing-fracture-risk-in-early-stage-breast-cancer-patients-treated-with-aromatase-inhibitors-an-enhanced-screening-approach-incorporating-trabecular-bone-score
#2
Veronica Mariotti, David B Page, Oksana Davydov, Didier Hans, Clifford A Hudis, Sujata Patil, Siddharth Kunte, Monica Girotra, Azeez Farooki, Monica N Fornier
INTRODUCTION: Aromatase-inhibitors (AIs) are commonly used for treatment of patients with hormone-receptor positive breast carcinoma, and are known to induce bone density loss and increase the risk of fractures. The current standard-of-care screening tool for fracture risk is bone mineral density (BMD) by dual-energy X-ray absorptiometry (DXA). The fracture risk assessment tool (FRAX®) may be used in conjunction with BMD to identify additional osteopenic patients at risk of fracture who may benefit from a bone-modifying agent (BMA)...
June 2017: Journal of Bone Oncology
https://www.readbyqxmd.com/read/28625602/frax-score-can-be-used-to-avoid-superfluous-dxa-scans-in-detecting-osteoporosis-in-celiac-disease-accuracy-of-the-frax-score-in-celiac-patients
#3
Raffaella Tortora, Nicola Imperatore, Pietro Capone, Nicolò Gerbino, Matilde Rea, Giovanna Affinito, Nicola Caporaso, Antonio Rispo
The Fracture Risk Assessment (FRAX) tool has been developed to estimate patients' 10-yr probability of fracture, thus establishing which patients should undergo dual-energy X-ray Absorptiometry (DXA) scan. This study aimed to evaluate if the FRAX tool can replace or optimize the use of DXA scan in celiac disease (CD). We prospectively enrolled all CD patients aged over 40 yr diagnosed at our third-level unit. At time of CD diagnosis, all patients underwent FRAX score calculation for risk of major osteoporotic and hip fractures and DXA scan (used as gold standard) to assess the accuracy of the FRAX score...
June 15, 2017: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/28613988/cost-effectiveness-of-virtual-bone-strength-testing-in-osteoporosis-screening-programs-for-postmenopausal-women-in-the-united-states
#4
Christoph A Agten, Austin J Ramme, Stella Kang, Stephen Honig, Gregory Chang
Purpose To investigate whether assessment of bone strength with quantitative computed tomography (CT) in combination with dual-energy x-ray absorptiometry (DXA) is cost-effective as a screening tool for osteoporosis in postmenopausal women. Materials and Methods A state-transition microsimulation model of osteoporosis for postmenopausal women aged 55 years or older was developed with a lifetime horizon and U.S. societal perspective. All model inputs were derived from published literature. Three strategies were compared: no screening, DXA with T score-dependent rescreening intervals, and a combination of DXA and quantitative CT with different intervals (3, 5, and 10 years) at different screening initiation ages (55-65 years)...
June 14, 2017: Radiology
https://www.readbyqxmd.com/read/28607522/agreement-between-fragility-fracture-risk-assessment-algorithms-as-applied-to-adults-with-chronic-spinal-cord-injury
#5
T Cervinka, C L Lynch, L Giangregorio, J D Adachi, A Papaioannou, L Thabane, B C Craven
STUDY DESIGN: Cross-sectional. OBJECTIVES: The objective of the study was to determine and report agreement in fracture risk stratification of adults with spinal cord injury (SCI) using (1) Canadian Association of Radiologists and Osteoporosis Canada (CAROC) and Canadian Fracture Risk Assessment (FRAX) tools with and without areal bone mineral density (aBMD) and (2) SCI-specific fracture thresholds. SETTING: Tertiary rehabilitation center, Ontario, Canada...
June 13, 2017: Spinal Cord
https://www.readbyqxmd.com/read/28599401/the-frequency-of-bone-fractures-among-patients-with-chronic-kidney-disease-not-on-dialysis-two-year-follow-up
#6
Andreja Figurek, Vlastimir Vlatkovic, Dragan Vojvodic, Branislav Gasic, Milorad Grujicic
INTRODUCTION: Renal osteodystrophy is a severe complication of chronic kidney disease (CKD) that increases morbidity and mortality in these patients. Mineral and bone disorder starts early in CKD and affects the incidence of bone fractures. The aim of this study was to observe the frequency of diverse bone fractures in patients with CKD not on dialysis. METHODS: This cohort study included 68 patients, that were followed during the two-year period. The patients were divided in two cohorts: one that developed bone fractures and the other that did not...
May 22, 2017: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/28593449/frax-for-fracture-prediction-shorter-and-longer-than-10%C3%A2-years-the-manitoba-bmd-registry
#7
W D Leslie, S R Majumdar, S N Morin, L M Lix, H Johansson, A Oden, E V McCloskey, J A Kanis
In a large clinical registry for the province of Manitoba, Canada, FRAX predicted incident MOF and hip fracture from 1 to 15 years following baseline assessment. A simple linear rescaling of FRAX outputs seems useful for predicting both short- and long-term fracture risk in this population. INTRODUCTION: FRAX® estimates 10-year probability of major osteoporotic fracture (MOF) and hip fracture. We examined FRAX predictions over intervals shorter and longer than 10 years. METHODS: Using a population-based clinical registry for Manitoba, Canada, we identified 62,275 women and 6455 men 40 years and older with baseline dual-energy X-ray absorptiometry scans and FRAX scores...
June 7, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28591341/the-effect-of-frax-on-the-prediction-of-osteoporotic-fractures-in-urban-middle-aged-and-elderly-healthy-chinese-adults
#8
Jun Wang, Xuejun Wang, Zhen Fang, Nanjia Lu, Liyuan Han
OBJECTIVE: We aimed to analyze the applicability of a fracture risk assessment tool for the prediction of osteoporotic fractures in middle-aged and elderly healthy Chinese adults. METHODS: A standard questionnaire was administered, and bone mineral density was measured in residents visiting the Dongliu Street Community Health Service Center. Paired t-tests were used to compare the FRAX-based probabilities of fractures estimated with and without consideration of bone mineral density...
May 2017: Clinics
https://www.readbyqxmd.com/read/28578992/the-impact-of-fragility-fracture-and-approaches-to-osteoporosis-risk-assessment-worldwide
#9
Elizabeth M Curtis, Rebecca J Moon, Nicholas C Harvey, Cyrus Cooper
Osteoporosis constitutes a major public health problem, through its association with age-related fractures, particularly of the hip, vertebrae, distal forearm and humerus. Substantial geographic variation has been noted in the incidence of osteoporotic fractures worldwide, with Western populations (North America, Europe and Oceania), reporting increases in hip fracture throughout the second half of the 20th century, with a stabilisation or decline in the last two decades. In developing populations however, particularly in Asia, the rates of osteoporotic fracture appears to be increasing...
April 26, 2017: International Journal of Orthopaedic and Trauma Nursing
https://www.readbyqxmd.com/read/28567714/epidemiology-of-hip-fracture-and-the-development-of-frax-in-ukraine
#10
V V Povoroznyuk, N V Grygorieva, J A Kanis, McCloskey Ev, H Johansson, N C Harvey, M O Korzh, S S Strafun, V M Vaida, F V Klymovytsky, R O Vlasenko, V S Forosenko
A country-specific FRAX model has been developed for the Ukraine to replace the Austrian model hitherto used. Comparison of the Austrian and Ukrainian models indicated that the former markedly overestimated fracture probability whilst correctly stratifying risk. INTRODUCTION: FRAX has been used to estimate osteoporotic fracture risk since 2009. Rather than using a surrogate model, the Austrian version of FRAX was adopted for clinical practice. Since then, data have become available on hip fracture incidence in the Ukraine...
December 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/28546806/clarifying-world-heaith-organization-position-on-the-frax-%C3%A2-tool
#11
Laragh Gollogly
No abstract text is available yet for this article.
March 2017: Przeglad Menopauzalny, Menopause Review
https://www.readbyqxmd.com/read/28530076/-osteoporosis-and-diabetes-in-which-way-are-they-related
#12
REVIEW
Osnat Tell-Lebanon, Pnina Rotman-Pikielny
Diabetes and osteoporosis are common diseases with growing prevalence in the aging population. Many recent studies have reported an association between diabetes mellitus and an increased osteoporotic fracture rate. Compared to control subjects, decreased bone mineral density has been observed in patients with type 1 diabetes mellitus, while those with type 2 diabetes display a unique skeletal phenotype of increased bone mineral density, but impaired architectural structure and mineral properties. Accumulation of advanced glycation end products changes collagen structure and suppression of bone turnover causes impairment of repair and adaptation mechanisms...
November 2016: Harefuah
https://www.readbyqxmd.com/read/28520844/fracture-risk-assessment-with-frax-using-real-world-data-a-population-based-cohort-from-israel
#13
Inbal Goldshtein, Yariv Gerber, Sophia Ish-Shalom, Moshe Leshno
The predictive value of the WHO fracture risk assessment tool was evaluated using real-world community data. A population-based cohort of 141,320 women aged 50-90 years old (median age 58, inter quartile range (IQR): 54-67) at the year 2004 was extracted from the central database of a large Israeli healthcare services provider and insurer. Retrospective FRAX scores were calculated using computerized health records and compared to actual incident major osteoporotic fractures (MOF) during the following 10 years...
May 18, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28500828/the-impact-of-thyroid-autoimmunity-tpoab-on-bone-density-and-fracture-risk-in-postmenopausal-women
#14
Snezana P Polovina, Dragana Miljic, Sladjana Zivojinovic, Natasa Milic, Dragan Micic, Vera Popovic Brkic
OBJECTIVE: Skeletal development, linear growth, cartilage biology and bone turnover are highly dependent on the activity of thyroid hormones. Thyroid dysfunction affects the skeleton, and autoimmune thyroid disease, manifesting as a chronic inflammatory condition, may be an important contributing factor to impaired bone quality in these patients. MATERIALS AND METHODS: Measurement of TSH, FT4, TPOAb and bone mineral density and FRAX score calculations were performed in 189 postmenopausal women (110 euthyroid women and 79 women diagnosed with subclinical hypothyroidism) divided into subgroups according to the presence of TPOAb...
January 2017: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28479495/adjusting-frax%C3%A2-on-tbs-for-identification-of-subjects-at-high-risk-of-fractures
#15
G Couraud, C Souffir, E Gaigneux, S Kolta, C Roux, K Briot
The objective of this study was to compare the proportion of patients at high fracture risk according to FRAX® and FRAX® adjusted on TBS in patients hospitalized for a non vertebral fractures. Patients were selected from a Fracture Liaison Service FLS): clinical risk factors, bone mineral density (BMD) and TBS were assessed at the time of the fracture. Without considering the current fracture, we calculated FRAX® and FRAX® adjusted on TBS (TBS-FRAX®), and compared the proportion of patients with a high risk for major osteoporotic fracture (MOF)>20% according to FRAX® and TBS-FRAX®, and the proportion of subjects who should be treated according to current guidelines...
May 4, 2017: Bone
https://www.readbyqxmd.com/read/28476576/non-bmd-dxa-measurements-of-the-hip
#16
Clinten P Edmondson, Elliott N Schwartz
Hip fracture is one of the most serious complications of osteoporosis. More than 50% of hip and other fractures occur in patients without densitometric osteoporosis. Therefore, areal bone mineral density (aBMD) may not be the best way to assess fracture risk. In order to improve assessment of fracture risk, many other approaches have been taken. At the present time, the Fracture Risk Algorithm (FRAX©) is one of the most notable ways to improve assessment of fracture risk. However, since early in the initiation of the dual energy x-ray absorptiometry (DXA) era, several non-BMD DXA approaches to the assessment of hip fracture risk have been proposed...
May 2, 2017: Bone
https://www.readbyqxmd.com/read/28474780/the-effect-of-abaloparatide-sc-on-fracture-risk-is-independent-of-baseline-frax-fracture-probability-a-post-hoc-analysis-of-the-active-study
#17
McCloskey Ev, Johansson H, Oden A, Harvey Nc, Jiang H, Modin S, L Fitzpatrick, Kanis J A
Daily subcutaneous (SC) injections of the investigational drug abaloparatide-SC (80mcg) for 18 months significantly decrease the risk of vertebral and non-vertebral fracture compared with placebo in postmenopausal women. We examined the efficacy of abaloparatide-SC as a function of baseline fracture risk, assessed using the FRAX tool. Baseline clinical risk factors (age, BMI, prior fracture, glucocorticoid use, rheumatoid arthritis, and smoking) were entered into country-specific FRAX models to calculate the 10-year probability of major osteoporotic fractures, with or without femoral neck BMD...
May 5, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28471962/evaluating-osteoporotic-fracture-risk-with-the-fracture-risk-assessment-tool-in-chinese-patients-with-rheumatoid-arthritis
#18
Juan Meng, Yanchun Li, Xiaoxu Yuan, Yuewu Lu
This study aims to evaluate the discriminative and predictive capacity of the Fracture Risk Assessment Tool (FRAX) to determine the 10-year risk of osteoporotic fracture in Chinese rheumatoid arthritis (RA) patients.This study included 168 RA patients and 168 healthy individuals as controls. The Chinese mainland FRAX model was applied to calculate the 10-year risk of osteoporotic fractures, defined as fracture of the spine, forearm, hip, or shoulder.The incidence of osteoporosis was significantly increased in RA patients compared to controls (P < ...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28459415/frax-based-estimates-of-10-year-probability-of-hip-and-major-osteoporotic-fracture-among-adults-aged-40-and-over-united-states-2013-and-2014
#19
Anne C Looker, Neda Sarafrazi Isfahani, Bo Fan, John A Shepherd
BACKGROUND: The FRAX algorithm estimates the 10-year probability of hip and major osteoporotic (clinical spine, forearm, hip, or humerus) fracture for adults aged 40 and over. An expert panel developed criteria to define elevated FRAX probabilities for U.S. adults aged 50 and over. This report uses FRAX estimates from the National Health and Nutrition Examination Survey 2013-2014 to describe the hip and major osteoporotic fracture probability distribution (for adults aged 40 and over) and prevalence of elevated probabilities (for adults aged 50 and over) in the United States...
March 2017: National Health Statistics Reports
https://www.readbyqxmd.com/read/28451714/diabetes-bone-and-glucose-lowering-agents-clinical-outcomes
#20
REVIEW
Ann V Schwartz
Older adults with diabetes are at higher risk of fracture and of complications resulting from a fracture. Hence, fracture risk reduction is an important goal in diabetes management. This review is one of a pair discussing the relationship between diabetes, bone and glucose-lowering agents; an accompanying review is provided in this issue of Diabetologia by Beata Lecka-Czernik (DOI 10.1007/s00125-017-4269-4 ). Specifically, this review discusses the challenges of accurate fracture risk assessment in diabetes...
April 27, 2017: Diabetologia
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