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https://www.readbyqxmd.com/read/28159710/trabecular-bone-score-tbs-method-and-applications
#1
P Martineau, W D Leslie
Trabecular bone score (TBS) is a texture index derived from standard lumbar spine dual energy X-ray absorptiometry (DXA) images and provides information about the underlying bone independent of the bone mineral density (BMD). Several salient observations have emerged. Numerous studies have examined the relationship between TBS and fracture risk and have shown that lower TBS values are associated with increased risk for major osteoporotic fracture in postmenopausal women and older men, with this result being independent of BMD values and other clinical risk factors...
February 1, 2017: Bone
https://www.readbyqxmd.com/read/28151883/beyond-bone-mineral-density-frax-based-tailor-made-intervention-thresholds-for-therapeutic-decision-in-subjects-on-glucocorticoid-a-nationwide-osteoporosis-survey
#2
Shan-Fu Yu, Jia-Feng Chen, Yin-Chou Chen, Han-Ming Lai, Chi-Hua Ko, Wen-Chan Chiu, Fu-Mei Su, Chung-Yuan Hsu, Ben Yu-Jih Su, Chih-Hsing Wu, Tien-Tsai Cheng
Glucocorticoid-induced osteoporosis (GIOP) is the most common cause of secondary osteoporosis and confers a substantial risk for future fractures. Several recent guidelines for GIOP management have recommended the use of intervention thresholds to direct pharmacological therapy in those at high risk of fracture. The aim of this study was to analyze the characteristics of subjects on a glucocorticoid (GC) and to implement the Fracture Risk Assessment Tool (FRAX)-based intervention threshold for therapeutic decision-making...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28131130/trabecular-bone-score-a-new-dxa-derived-measurement-for-fracture-risk-assessment
#3
REVIEW
Barbara C Silva, William D Leslie
Trabecular bone score (TBS) is a novel method that assesses skeletal texture from spine dual-energy X-ray absorptiometry (DXA) images. TBS improves fracture-risk prediction beyond that provided by DXA bone mineral density (BMD) and clinical risk factors, and can be incorporated to the Word Health Organization Fracture Risk Assessment tool (FRAX®) to enhance fracture prediction. There is insufficient evidence that TBS can be used to monitor treatment with bisphosphonates. TBS may be particularly helpful to assess fracture risk in diabetes...
March 2017: Endocrinology and Metabolism Clinics of North America
https://www.readbyqxmd.com/read/28127556/trabecular-bone-score-reflects-trabecular-microarchitecture-deterioration-and-fragility-fracture-in-female-adult-patients-receiving-glucocorticoid-therapy-a-pre-post-controlled-study
#4
Mei-Hua Chuang, Tzyy-Ling Chuang, Malcolm Koo, Yuh-Feng Wang
A recently developed diagnostic tool, trabecular bone score (TBS), can provide quality of trabecular microarchitecture based on images obtained from dual-energy X-ray absorptiometry (DXA). Since patients receiving glucocorticoid are at a higher risk of developing secondary osteoporosis, assessment of bone microarchitecture may be used to evaluate risk of fragility fractures of osteoporosis. In this pre-post study of female patients, TBS and fracture risk assessment tool (FRAX) adjusted with TBS (T-FRAX) were evaluated along with bone mineral density (BMD) and FRAX...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28119181/the-impact-of-fragility-fracture-and-approaches-to-osteoporosis-risk-assessment-worldwide
#5
Elizabeth M Curtis, Rebecca J Moon, Nicholas C Harvey, Cyrus Cooper
Osteoporosis constitutes a major public health problem, through its association with age-related fractures, particularly of the hip, vertebrae, distal forearm and humerus. Substantial geographic variation has been noted in the incidence of osteoporotic fractures worldwide, with Western populations (North America, Europe and Oceania), reporting increases in hip fracture throughout the second half of the 20th century, with a stabilisation or decline in the last two decades. In developing populations however, particularly in Asia, the rates of osteoporotic fracture appears to be increasing...
January 22, 2017: Bone
https://www.readbyqxmd.com/read/28118961/agreement-of-mexican-frax-with-and-without-the-value-of-bone-mineral-density-in-assessing-the-risk-of-fracture-in-daily-clinical-practice
#6
Gabriel Horta-Baas, Arturo Pérez Bolde-Hernández, Argelia Pérez-Pérez, Imelda Vergara-Sánchez, María Del Socorro Romero-Figueroa
INTRODUCTION: The use of FRAX without the inclusion of bone mineral density (FRAX-BMI) may be useful in clinical practice to identify patients at high risk of fracture and inform treatment decisions, but its usefulness is debated. The aim of the study is to evaluate the agreement between the risk of fracture calculated by FRAX with or without bone mineral density (BMD). PATIENTS AND METHODS: A cross-sectional study was conducted with 431 women (40-90 years) without treatment...
January 21, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28104610/external-validation-and-comparison-of-three-prediction-tools-for-risk-of-osteoporotic-fractures-using-data-from-population-based-electronic-health-records-retrospective-cohort-study
#7
Noa Dagan, Chandra Cohen-Stavi, Maya Leventer-Roberts, Ran D Balicer
OBJECTIVE:  To directly compare the performance and externally validate the three most studied prediction tools for osteoporotic fractures-QFracture, FRAX, and Garvan-using data from electronic health records. DESIGN:  Retrospective cohort study. SETTING:  Payer provider healthcare organisation in Israel. PARTICIPANTS:  1 054 815 members aged 50 to 90 years for comparison between tools and cohorts of different age ranges, corresponding to those in each tools' development study, for tool specific external validation...
January 19, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28074251/hyponatremia-and-fractures-should-hyponatremia-be-further-studied-as-a-potential-biochemical-risk-factor-to-be-included-in-frax-algorithms
#8
REVIEW
J C Ayus, T Bellido, A L Negri
The Fracture Risk Assessment Tool (FRAX®) was developed by the WHO Collaborating Centre for metabolic bone diseases to evaluate fracture risk of patients. It is based on patient models that integrate the risk associated with clinical variables and bone mineral density (BMD) at the femoral neck. The clinical risk factors included in FRAX were chosen to include only well-established and independent variables related to skeletal fracture risk. The FRAX tool has acquired worldwide acceptance despite having several limitations...
January 10, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28041872/use-of-dual-energy-x-ray-absorptiometry-dxa-for-diagnosis-and-fracture-risk-assessment-who-criteria-t-and-z-score-and-reference-databases
#9
Hans P Dimai
Dual-energy X-ray absorptiometry (DXA) is a two-dimensional imaging technology developed to assess bone mineral density (BMD) of the entire human skeleton and also specifically of skeletal sites known to be most vulnerable to fracture. In order to simplify interpretation of BMD measurement results and allow comparability among different DXA-devices, the T-score concept was introduced. This concept involves an individual's BMD which is then compared with the mean value of a young healthy reference population, with the difference expressed as a standard deviation (SD)...
December 29, 2016: Bone
https://www.readbyqxmd.com/read/28025971/-primary-and-secondary-prevention-of-hip-fragility-fracture-in-teruel-health-sector-aragon-spain
#10
Rafael Gómez Navarro, Paloma González García, Carlos Martín Hernández, Ángel Castro Sauras, Santiago Valdearcos Enguídanos
OBJECTIVE: Osteoporosis should be prevented, diagnosed and treated, preferably before the fragility fracture occurs. The objective was to analyze primary and secondary interventions carried out in individuals diagnosed with femur fragility fracture at Teruel in 2014. METHODS: Descriptive retrospective study. Variables assessed were sex, age, main health district, place of residence, basal functional situation, diagnosis on osteoporosis, hip or vertebral fracture, loss of height, use of FRAX tool, treatment on discharge, survival and cause of exitus...
January 2, 2017: Revista Española de Salud Pública
https://www.readbyqxmd.com/read/28013446/evaluation-of-the-validity-of-osteoporosis-and-fracture-risk-assessment-tools-iof-one-minute-test-score-and-frax-in-postmenopausal-palestinian-women
#11
Akram Kharroubi, Elias Saba, Ibrahim Ghannam, Hisham Darwish
: The need for simple self-assessment tools is necessary to predict women at high risk for developing osteoporosis. In this study, tools like the IOF One Minute Test, Fracture Risk Assessment Tool (FRAX), and Simple Calculated Osteoporosis Risk Estimation (SCORE) were found to be valid for Palestinian women. The threshold for predicting women at risk for each tool was estimated. PURPOSE: The purpose of this study is to evaluate the validity of the updated IOF (International Osteoporosis Foundation) One Minute Osteoporosis Risk Assessment Test, FRAX, SCORE as well as age alone to detect the risk of developing osteoporosis in postmenopausal Palestinian women...
December 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/28004298/comparing-self-perceived-and-estimated-fracture-risk-by-frax%C3%A2-of-women-with-osteoporosis
#12
Petra Baji, László Gulácsi, Csaba Horváth, Valentin Brodszky, Fanni Rencz, Márta Péntek
: In this study, we compared subjective fracture risks of Hungarian women with osteoporosis to FRAX®-based estimates. Patients with a previous fracture, parental hip fracture, low femoral T-score, higher age, and higher BMI were more likely to underestimate their risks. Patients also failed to associate risk factors with an increased risk of fractures. PURPOSE: The main objectives were to explore associations between self-perceived 10-year fracture risks of women with osteoporosis (OP) and their risks calculated by the FRAX® algorithm and to identify determinants of the underestimation of risk...
December 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/28004297/evaluation-of-the-first-fracture-liaison-service-in-the-greek-healthcare-setting
#13
Polyzois Makras, Maria Panagoulia, Andriana Mari, Stavroula Rizou, George P Lyritis
: We evaluated the first implementation of FLS in the Greek healthcare setting, at the 251 Hellenic Air Force and VA General Hospital of Athens. Participation rate was moderate (54.5%) and needs improvement; osteoporosis medication was either suggested or reviewed in 74 out of the 116 patients recruited. PURPOSE: The purpose of this study was to evaluate the first implementation of a fracture liaison service (FLS) in Greece, at the 251 Hellenic Air Force and VA General Hospital, Athens...
December 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/27994275/clarifying-who-s-position-on-the-frax%C3%A2-tool-for-fracture-prediction
#14
EDITORIAL
Nathan Ford, Susan L Norris, Suzanne R Hill
No abstract text is available yet for this article.
December 1, 2016: Bulletin of the World Health Organization
https://www.readbyqxmd.com/read/27966104/the-impact-of-the-new-national-bone-health-alliance-nbha-diagnostic-criteria-on-the-prevalence-of-osteoporosis-in-the-usa
#15
N C Wright, K G Saag, B Dawson-Hughes, S Khosla, E S Siris
: We evaluated the prevalence of osteoporosis using the osteoporosis diagnostic criteria developed by the National Bone Health Alliance (NBHA), which includes qualified fractures, FRAX score in addition to bone mineral density (BMD). The expanded definition increases the prevalence compared to BMD alone definitions; however, it may better identify those at elevated fracture risk. PURPOSE: The purpose of this paper is to estimate the prevalence of osteoporosis in US adults ≥50 years using the NBHA osteoporosis diagnostic criteria...
December 13, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27900532/mir-148a-the-epigenetic-regulator-of-bone-homeostasis-is-increased-in-plasma-of-osteoporotic-postmenopausal-women
#16
Ajda Bedene, Simona Mencej Bedrač, Lea Ješe, Janja Marc, Peter Vrtačnik, Janez Preželj, Tomaž Kocjan, Tilen Kranjc, Barbara Ostanek
BACKGROUND: Osteoporosis is a prevalent skeletal disorder characterized by reduced bone mineral density and microarchitectural deterioration of bone tissue, resulting in bone fragility and low-trauma fractures. Imaging techniques are routinely used to detect low bone mass; however, they are unable to identify deterioration of bone quality. Recently, microRNAs have emerged as regulators of bone remodelling and potentially also as a new class of sensitive biomarkers of bone health to aid in diagnosis and treatment monitoring of osteoporosis...
December 2016: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/27889053/osteoporosis-in-postmenopausal-women-living-with-hiv
#17
REVIEW
Fionnuala Finnerty, Karen Walker-Bone, Shema Tariq
The widespread availability of effective antiretroviral therapy (ART) has transformed HIV from a life-limiting condition to one with near-normal life expectancy. HIV is associated with an increased risk of osteopenia and osteoporosis, with people living with HIV (PLHIV) potentially experiencing these conditions at a younger age than their HIV-negative counterparts. The mechanisms driving bone disease in HIV are complex and include: an increased prevalence of traditional risk factors; other comorbid conditions; and HIV-associated factors such as viral effects, systemic inflammation, and ART-related factors...
January 2017: Maturitas
https://www.readbyqxmd.com/read/27875059/cortical-bone-area-predicts-incident-fractures-independently-of-areal-bone-mineral-density-in-older-men
#18
Claes Ohlsson, Daniel Sundh, Andreas Wallerek, Martin Nilsson, Magnus Karlsson, Helena Johansson, Dan Mellström, Mattias Lorentzon
CONTEXT: Areal bone mineral density (aBMD) measured using dual-energy X-ray absorptiometry (DXA) is used clinically to predict fracture but does not allow discrimination between the trabecular and cortical bone compartments or assessment of cortical porosity. OBJECTIVE: To investigate if distinct information on cortical and trabecular bone parameters predict fracture risk independently of aBMD and clinical risk factors. DESIGN & PARTICIPANTS: Cortical area, cortical bone mass, trabecular bone volume fraction, and cortical porosity were measured at the tibia using high-resolution peripheral quantitative computed tomography (HR-pQCT) in 456 men (80...
November 22, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27844133/gait-speed-and-one-leg-standing-time-each-add-to-the-predictive-ability-of-frax
#19
H Lundin, M Sääf, L-E Strender, S Nyren, S-E Johansson, H Salminen
: Gait speed or one-leg standing time (OLST) as additional predictors in FRAX. Population 351 elderly women followed 10 years. Both could improve predictions. The area under curve (AUC) for FRAX is 0.59, OLST is 0.69 and gait speed is 0.71. The net reclassification index (NRI) for classification to highest risk quartile or lowest three quartiles was 0.24 for gait speed and non-significant for OLST. INTRODUCTION: The risk of falls and bone strength are two main determinants of hip fracture risk...
January 2017: Osteoporosis International
https://www.readbyqxmd.com/read/27801641/a-systematic-review-and-economic-evaluation-of-bisphosphonates-for-the-prevention-of-fragility-fractures
#20
Sarah Davis, Marrissa Martyn-St James, Jean Sanderson, John Stevens, Edward Goka, Andrew Rawdin, Susi Sadler, Ruth Wong, Fiona Campbell, Matt Stevenson, Mark Strong, Peter Selby, Neil Gittoes
BACKGROUND: Fragility fractures are fractures that result from mechanical forces that would not ordinarily result in fracture. OBJECTIVES: To evaluate the clinical effectiveness and safety of bisphosphonates [alendronic acid (Fosamax(®) and Fosamax(®) Once Weekly, Merck Sharp & Dohme Ltd), risedronic acid (Actonel(®) and Actonel Once a Week(®), Warner Chilcott UK Ltd), ibandronic acid (Bonviva(®), Roche Products Ltd) and zoledronic acid (Aclasta(®), Novartis Pharmaceuticals UK Ltd)] for the prevention of fragility fracture and to assess their cost-effectiveness at varying levels of fracture risk...
October 2016: Health Technology Assessment: HTA
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