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https://www.readbyqxmd.com/read/28926113/skeletal-fragility-in-diabetes
#1
REVIEW
Mishaela R Rubin
Fracture risk is heightened in patients with both type 1 diabetes (T1D) and type 2 diabetes (T2D). Although bone mineral density by dual-energy X-ray absorptiometry is decreased in T1D, it is paradoxically increased with T2D. To predict fracture risk, the Fracture Risk Assessment Tool (FRAX) can be used in diabetes patients, albeit with refinement. Skeletal abnormalities in diabetes include alterations in microarchitecture in T1D and T2D as well as compromised impact microindentation in T2D. Changes in bone microvasculature, advanced glycation end product accumulation, and bone formation may underlie these findings...
August 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28913949/relationship-of-number-of-missing-teeth-to-hip-fracture-in-elderly-patients-a-cohort-pilot-study
#2
Jennifer Priebe, Robert A Wermers, Stephen A Sems, Christopher M Viozzi, Sreenivas Koka
PURPOSE: To determine the relationship between the number of missing natural teeth or remaining natural teeth and osteoporotic hip fracture in elderly patients and to determine the relationship between the number of missing teeth or remaining teeth and osteoporotic fracture risk assessment (FRAX) probability. MATERIALS AND METHODS: Number of missing teeth was determined by clinical oral exam on a total of 100 subjects, 50 with hip fractures and 50 without. Ten-year fracture risk and hip fracture risk probabilities were calculated using the FRAX tool...
September 15, 2017: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/28913002/corrigendum-to-mikkeli-osteoporosis-index-identifies-fracture-risk-factors-and-osteoporosis-and-intervention-thresholds-parallel-with-frax
#3
Ville Juhana Waris, Joonas P Sirola, Vesa V Kiviniemi, Marjo T Tuppurainen, V Pekka Waris
[This corrects the article DOI: 10.4061/2011/732560.].
2017: Journal of Osteoporosis
https://www.readbyqxmd.com/read/28912392/-refracture-prevention-and-rehabilitation
#4
Hiroaki Fujita
Osteoporosis Liaison Service(OLS)is not only the fracture prevention of the onset, and the refracture prevention holds important positioning. For OLS activity in the hospitals of the fracture risk by FRAX grasp it, and it is important to evaluate the fall risk. What an interval, a motor function including the lower limbs muscular strength evaluate in a fall risk evaluation and TUG and walking speed temporarily for a fall risk evaluation for, the eye opening single leg right time to leave is desirable. It is a problem that an evaluation and treatment for osteoporosis are insufficient by recent DPC induction...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/28912385/-primary-fracture-prevention-through-the-osteoporosis-liaison-service
#5
Shinichi Nakatoh
It is difficult to prevent primary fragility fractures because the subjects have not yet experienced a fracture. The offers of the community Osteoporosis Liaison Service are important for primary prevention of fragility fractures. The prevention, education, enlightenment, and the offer of osteoporosis examinations are included in this service. It is necessary to deliver the prevention services and osteoporosis education according to the age of the subjects. Hence, for young people, it is effective to include in school education that getting high peak bone mass is important, and for the middle-aged population, it is necessary to include education on the maintenance of bone quantity and the impact on risk factors such as smoking and excessive alcohol consumption...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/28899596/frax-vs-caroc-for-the-canadian-imaging-physician-an-existential-dilemma
#6
REVIEW
Ian Hammond, Steven Burrell, David J Lyons, Brian C Lentle
No abstract text is available yet for this article.
September 9, 2017: Canadian Association of Radiologists Journal, Journal L'Association Canadienne des Radiologistes
https://www.readbyqxmd.com/read/28884422/less-strict-intervention-thresholds-for-the-frax-and-tbs-adjusted-frax-predict-clinical-fractures-in-osteopenic-postmenopausal-women-with-no-prior-fractures
#7
Martin Kužma, Didier Hans, Tomáš Koller, Eva Némethová, Peter Jackuliak, Zdenko Killinger, Heinrich Resch, Juraj Payer
Little is known about the clinical relevance of treating post-menopausal women with no prior history of fragility fracture and bone mineral densities (BMD) within the osteopenic range. In recent years, in addition to BMD and FRAX fracture probability assessments, a surrogate measure of bone micro-architecture quality, called the trabecular bone score (TBS), has been proven to predict future fragility fractures independently of both BMD and the FRAX. In this retrospective analysis of a follow-up study, we compared three risk assessment instruments-the FRAX, the TBS, and a TBS-adjusted FRAX score-in their ability, to predict future fragility fractures over a minimum of five years of follow-up among post-menopausal osteopenic women with no prior fragility fractures...
September 7, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/28875257/non-participation-in-systematic-screening-for-osteoporosis-the-rose-trial
#8
M J Rothmann, S Möller, T Holmberg, M Højberg, J Gram, M Bech, K Brixen, A P Hermann, C-C Glüer, R Barkmann, K H Rubin
Population-based screening for osteoporosis is still controversial and has not been implemented. Non-participation in systematic screening was evaluated in 34,229 women age 65-81 years. Although participation rate was high, non-participation was associated with comorbidity, aging other risk factors for fractures, and markers of low social status, e.g., low income, pension, and living alone. A range of strategies is needed to increase participation, including development of targeted information and further research to better understand the barriers and enablers in screening for osteoporosis...
September 5, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28861636/self-perception-of-fracture-risk-what-can-it-tell-us
#9
A E Litwic, J E Compston, A Wyman, E S Siris, S H Gehlbach, J D Adachi, R Chapurlat, A Díez-Pérez, A Z LaCroix, J W Nieves, J C Netelenbos, J Pfeilschifter, M Rossini, C Roux, K G Saag, S Silverman, N B Watts, S L Greenspan, L March, C L Gregson, C Cooper, E M Dennison
In this study, we report that self-perception of fracture risk captures some aspect of fracture risk not currently measured using conventional fracture prediction tools and is associated with improved medication uptake. It suggests that adequate appreciation of fracture risk may be beneficial and lead to greater healthcare engagement and treatment. INTRODUCTION: This study aimed to assess how well self-perception of fracture risk, and fracture risk as estimated by the fracture prediction tool FRAX, related to fracture incidence and uptake and persistence of anti-osteoporosis medication among women participating in the Global Longitudinal study of Osteoporosis in Women (GLOW)...
August 31, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28857846/utility-of-trabecular-bone-score-in-the-evaluation-of-osteoporosis
#10
Patrick Martineau, Barbara C Silva, William D Leslie
PURPOSE OF REVIEW: Trabecular bone score (TBS) is a lumbar spine dual-energy absorptiometry texture index which provides information on skeletal quality partially independent of bone mineral density (BMD). A body of work has emerged demonstrating the relationship between TBS and fracture risk, with lower TBS values associated with increased risk for osteoporotic fracture in postmenopausal women and older men. TBS is derived from standard DXA images; however, the information provided by TBS is complementary to that provided by BMD...
August 28, 2017: Current Opinion in Endocrinology, Diabetes, and Obesity
https://www.readbyqxmd.com/read/28856390/hypogonadal-men-with-higher-body-mass-index-have-higher-bone-density-and-better-bone-quality-but-reduced-muscle-density
#11
Lina E Aguirre, Georgia Colleluori, Richard Dorin, David Robbins, Rui Chen, Bryan Jiang, Clifford Qualls, Dennis T Villareal, Reina Armamento-Villareal
Although hypogonadism is a risk factor for bone loss and fractures, the different etiopathophysiology and hormonal profile of classical and obesity-induced hypogonadism may lead to differences in musculoskeletal profile. This is a cross-sectional study of hypogonadal men between 40 and 74 years old. Our outcomes include: areal bone mineral density (aBMD) and body composition by dual-energy X-ray absorptiometry; volumetric BMD (vBMD) and soft tissue composition of the tibia by peripheral quantitative computed tomography...
August 30, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28815485/screening-for-osteoporosis-in-older-men-operating-characteristics-of-proposed-strategies-for-selecting-men-for-bmd-testing
#12
Susan J Diem, Katherine W Peters, Margaret L Gourlay, John T Schousboe, Brent C Taylor, Eric S Orwoll, Jane A Cauley, Lisa Langsetmo, Carolyn J Crandall, Kristine E Ensrud
BACKGROUND: The optimal approach for selecting men for bone mineral density (BMD) testing to screen for osteoporosis is uncertain. OBJECTIVE: To compare strategies for selecting older men for screening BMD testing. DESIGN: Prospective cohort study. PARTICIPANTS: A total of 4043 community-dwelling men aged ≥70 years at four US sites. MAIN MEASURES: BMD at the total hip, femoral neck, and lumbar spine using dual-energy x-ray absorptiometry (DXA)...
August 16, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/28782072/frax-vs-t-score-based-intervention-thresholds-for-osteoporosis
#13
H Johansson, F Azizieh, N Al Ali, T Alessa, N C Harvey, E McCloskey, J A Kanis
Many current guidelines for the assessment of osteoporosis, including those in Kuwait, initiate fracture risk assessment in men and women using BMD T-score thresholds. We compared the Kuwaiti guidelines with FRAX-based age-dependent intervention thresholds equivalent to that in women with a prior fragility fracture. FRAX-based intervention thresholds identified women at higher fracture probability than fixed T-score thresholds, particularly in the elderly. PURPOSE: A FRAX® model been recently calibrated for Kuwait, but guidance is needed on how to utilise fracture probabilities in the assessment and treatment of patients...
August 7, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28781230/fracture-risk-assessment-tool-frax%C3%A2-results-calculated-with-and-without-bone-mineral-density-values-for-the-evaluation-of-fracture-risk-in-postmenopausal-women-with-osteopenia
#14
Ahmet Imerci, Cem Yalın Kılınç, Nevres Hurriyet Aydogan, Mustafa Nazım Karalezli, Ahmet Savran
The aim of this study was to evaluate the agreement between fracture risk predictions based on calculations made with and without bone mineral density (BMD) values using the Fracture Risk Assessment Tool (FRAX®) in Turkish postmenopausal women with osteopenia and to compare the treatment recommendations. This descriptive, cross-sectional study included postmenopausal women aged 50-79 yr with a diagnosis of osteoporosis who were not receiving any treatment. A questionnaire was administered to the participants face-to-face to obtain sociodemographic characteristics, medical history, and fracture history...
August 3, 2017: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/28766739/serum-levels-of-a-cathepsin-k-generated-periostin-fragment-predict-incident-low-trauma-fractures-in-postmenopausal-women-independently-of-bmd-and-frax
#15
Nicolas Bonnet, Emmanuel Biver, Thierry Chevalley, René Rizzoli, Patrick Garnero, Serge L Ferrari
Periostin is a matricellular protein involved in bone formation and bone matrix organization, but it is also produced by other tissues. Its circulating levels have been weakly associated with bone microstructure and prevalent fractures, possibly because periostin measured by the current commercial assays does not specifically reflect bone metabolism. In this context, we developed a new ELISA for a periostin fragment resulting from cathepsin K digestion (K-Postn). We hypothesized that circulating K-Postn levels could be associated with bone fragility...
August 2, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28766137/inhaled-glucocorticoids-are-associated-with-vertebral-fractures-in-copd-patients
#16
Pedro Assed Gonçalves, Rafael Dos Santos Neves, Leonardo Vieira Neto, Miguel Madeira, Fernando Silva Guimarães, Laura Maria Carvalho Mendonça, Agnaldo Jose Lopes, Maria Lucia Fleiuss Farias
Chronic obstructive pulmonary disease (COPD) is an independent risk factor for osteoporosis. Oral glucocorticoids are deleterious to bone; however, the impact of inhaled glucocorticoids (ICS) remains unclear. Our objective was to determine whether ICS contribute to osteoporosis and fragility fractures. Sixty-one COPD patients, 35 current users of ICS and 26 who had never received glucocorticoids, were evaluated for bone mineral density (BMD) and body composition and underwent vertebral fracture assessment (VFA)...
August 1, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/28756457/a-comparison-of-electronic-and-manual-fracture-risk-assessment-tools-in-screening-elderly-male-us-veterans-at-risk-for-osteoporosis
#17
S T Williams, P T Lawrence, K L Miller, J L Crook, J LaFleur, G W Cannon, R E Nelson
This study compares four screening tools in their ability to predict osteoporosis. We found that there was no significant difference between the tools. These results provide support for the use of automated screening tools which work in conjunction with the electronic medical record and help improve screening rates for osteoporosis. INTRODUCTION: The purpose of this study is to compare the performance of four fracture risk assessment tools (FRATs) in identifying osteoporosis by bone mineral density (BMD) T-score: Veterans Affairs Fracture Absolute Risk Assessment Tool (VA-FARA), World Health Organization's Fracture Risk Assessment Tool (FRAX), electronic FRAX (e-FRAX), and Osteoporosis Self-Assessment Screening Tool (OST)...
July 30, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28743851/-new-methods-for-the-evaluation-of-bone-quality-dxa-based-analysis-of-bone-quality-trabecular-bone-score-tbs
#18
Teruki Sone
Trabecular bone score(TBS)is a texture measure that evaluates pixel gray-level variations in lumbar spine DXA images, and provides skeletal information distinct from the standard BMD measurement. Recent clinical evidences show that TBS is associated with fracture risk in primary and secondary osteoporosis, and can be used together with FRAX(R) and BMD to adjust FRAX-probability of fracture in postmenopausal women and older men. However, athough treatment-related increases are reflected in the TBS, these are considerably smaller than the changes in BMD and there is insufficient evidence that TBS can be used to assess response to pharmacologic treatment...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/28734710/use-of-trabecular-bone-score-tbs-as-a-complementary-approach-to-dual-energy-x-ray-absorptiometry-dxa-for-fracture-risk-assessment-in-clinical-practice
#19
Enisa Shevroja, Olivier Lamy, Lynn Kohlmeier, Fjorda Koromani, Fernando Rivadeneira, Didier Hans
Osteoporosis is a common bone disease characterized by low bone mass and altered bone microarchitecture, resulting in decreased bone strength with an increased risk of fractures. In clinical practice, physicians can assess the risk of fracture for a patient based on several risk factors. Some such as age, weight, and history of fractures after 50 years of age, parental fracture, smoking status, and alcohol intake are incorporated into FRAX, an assessment tool that estimates the 10-year probability of hip fracture and major osteoporotic fractures based on the individual's risk factors profile...
July 2017: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/28734709/worldwide-fracture-prediction
#20
Ghada El-Hajj Fuleihan, Marlene Chakhtoura, Jane A Cauley, Nariman Chamoun
The substantial increase in the burden of non-communicable diseases in general and osteoporosis in particular, necessitates the establishment of efficient and targeted diagnosis and treatment strategies. This chapter reviews and compares different tools for osteoporosis screening and diagnosis; it also provides an overview of different treatment guidelines adopted by countries worldwide. While access to dual-energy X-ray absorptiometry to measure bone mineral density (BMD) is limited in most areas in the world, the introduction of risk calculators that combine risk factors, with or without BMD, have resulted in a paradigm shift in osteoporosis screening and management...
July 2017: Journal of Clinical Densitometry
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