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https://www.readbyqxmd.com/read/29675745/a-proposal-for-an-atypical-femur-fracture-treatment-and-prevention-clinical-practice-guideline
#1
REVIEW
R Dell, D Greene
The prevention as well as the treatment of atypical femur fractures (AFFs) remains controversial but there have been many clinical recommendations suggested. We have summarized these recommendations as well as expanded upon them in this paper. INTRODUCTION: The purpose of the paper was to develop a clinical practice guideline that both treats AFF and decreases the risk of AFF in patients requiring antiresorptive medications. Examples of these medications include bisphosphonates and denosumab for the treatment of osteoporosis...
April 19, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29666948/epidemiology-of-hip-fracture-in-belarus-development-of-a-country-specific-frax-model-and-its-comparison-to-neighboring-country-models
#2
H Ramanau, I Chernyanin, E Rudenka, O Lesnyak, A Zakroyeva, J P Bilezikian, H Johansson, N C Harvey, E V McCloskey, J A Kanis
Fracture probabilities resulting from the newly generated FRAX model for Belarus based on regional estimates of the hip fracture incidence were compared with FRAX models of neighboring countries. Differences between the country-specific FRAX patterns and the rank orders of fracture probabilities were modest. OBJECTIVE: This paper describes the epidemiology of hip fractures in Belarus that was used to develop the country-specific fracture prediction FRAX® tool and illustrates its features compared to models for the neighboring countries of Poland, Russia, and Lithuania...
April 17, 2018: Archives of Osteoporosis
https://www.readbyqxmd.com/read/29661041/prospective-risk-of-osteoporotic-fractures-in-patients-with-advanced-chronic-obstructive-pulmonary-disease
#3
Ayushman Gupta, Neil J Greening, Rachael A Evans, Abigail Samuels, Nicole Toms, Michael C Steiner
Despite the high prevalence of osteoporosis in chronic obstructive pulmonary disease (COPD) patients, the fracture risk prediction tools are not routinely undertaken in the management of COPD. We quantified fracture risk using a validated risk prediction tool (Fracture Risk Assessment (FRAX®)) and determined potential bone-protection treatment needs in patients with advanced COPD. The 10-year probability of major osteoporotic or hip fracture was calculated using the FRAX tool in a cohort of patients attending a hospital complex COPD service...
January 1, 2018: Chronic Respiratory Disease
https://www.readbyqxmd.com/read/29658832/the-associations-between-hypovitaminosis-d-higher-pth-levels-with-bone-mineral-densities-and-risk-of-the-10-year-probability-of-major-osteoporotic-fractures-in-chinese-patients-with-t2dm
#4
Xiao-Feng Wang, Jing-Jia Yu, Xiao-Jing Wang, Yi-Xuan Jing, Li-Hao Sun, Bei Tao, Wei-Qing Wang, Guang Ning, Jian-Min Liu, Hong-Yan Zhao
OBJECTIVE: In the current study, we investigated the vitamin D status, and its relationships with parathyroid hormone (PTH) levels, bone mineral density (BMD), and the 10-year probability of fractures in Chinese patients with type 2 diabetes mellitus (T2DM). METHODS: This was a cross-sectional study of 785 patients. BMDs at the lumbar spine (L2-4), femoral neck (FN), and total hip (TH) were measured by dual-energy X-ray absorptiometry (DXA). Serum levels of 25-hydroxyvitamin D (25(OH)D) and intact PTH were also quantified...
April 2018: Endocrine Practice
https://www.readbyqxmd.com/read/29651509/the-role-of-previous-falls-in-major-osteoporotic-fracture-prediction-in-conjunction-with-frax-in-older-chinese-men-and-women-the-mr-os-and-ms-os-cohort-study-in-hong-kong
#5
Y Su, J Leung, T Kwok
Falls are a major concern in terms of fracture risk. Although awareness rising for the absence of falls in the FRAX algorithm, our study only identified the independent predictive role of previous recurrent falls and their better conjunction use with FRAX for major osteoporotic fracture prediction in older Chinese men.
April 12, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29650194/fracture-risk-prediction-in-post-menopausal-women-with-osteopenia-and-osteoporosis-preliminary-findings
#6
Nik Noor Kaussar Nik Mohd Hatta, Muhammad Lokman, Mohd Said N, Azlina Daud, Muhammad Ibrahim, Mohd Ariff Sharifudin, Samsul Deraman
OBJECTIVE: The study aims to identify the risk of obtaining a fracture among post-menopausal women with osteopenia and osteoporosis. METHOD: This work was a cross-sectional study involving a purposive sample of 87 post-menopausal women who attended the orthopedic and menopause clinics of Hospital Tengku Ampuan Afzan, Kuantan. The data were entered into the WHO fracture risk assessment tool (FRAX® ) to predict major fracture and risk for hip fracture in 10 years' time...
February 2018: Enfermería Clínica
https://www.readbyqxmd.com/read/29642719/impact-of-pharmacist-physician-collaboration-on-osteoporosis-treatment-rates
#7
Brandi L Bowers, Amy M Drew, Christian Verry
BACKGROUND: The vast majority of women at high risk for osteoporotic fractures are not treated, despite known significant clinical and economic consequences of this prevalent condition. To date, this is the first study of this size and duration to examine the role of pharmacists in management of osteoporosis in a family medicine clinic. OBJECTIVE: To compare the initiation or continuation of prescription antifracture therapy in high-risk patients with collaborative pharmacist-physician to physician-only management; secondarily, to evaluate recommendation rates for antifracture therapy and calcium and vitamin D...
April 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29624722/volumetric-bone-mineral-density-and-failure-load-of-distal-limbs-predict-incident-clinical-fracture-independent-of-frax-and-clinical-risk-factors-among-older-men
#8
Lisa Langsetmo, Katherine W Peters, Andrew J Burghardt, Kristine E Ensrud, Howard A Fink, Peggy M Cawthon, Jane A Cauley, John T Schousboe, Elizabeth Barrett-Connor, Eric S Orwoll
Our objective was to determine the associations of peripheral bone strength and microarchitecture with incident clinical and major osteoporotic fracture among older men after adjusting for major clinical risk factors. We used a prospective cohort study design with data from 1794 men (mean age 84.4 years) in the Osteoporotic Fractures in Men (MrOS) study. Eligible men attended the Year 14 visit, had high resolution peripheral quantitative computed tomography (HR-pQCT) scans of the distal radius and distal or diaphyseal tibia, DXA measured BMD, and were followed for mean 1...
April 6, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29619576/fracture-risk-prediction-using-frax-in-patients-following-hematopoietic-stem-cell-transplantation
#9
Xerxes Pundole, William A Murphy, Chidinma C Ebede, Erfan Karim, Srishti Manocha, Data Don-Pedro, Gabriela Rondon, Cheuk Hong Leung, Suyu Liu, Xianglin L Du, Richard E Champlin, Huifang Lu
We aimed to study the utility of the FRAX tool in predicting fractures in patient's receiving a hematopoietic stem cell transplantation (HSCT). Our results indicate that the FRAX tool has modest fracture predictive ability in patients greater than 50 years of age at the time of HSCT. PURPOSE: Identifying patients at high risk of osteoporotic fractures following HSCT is challenging. We aimed to evaluate the utility of the FRAX tool at the time of HSCT in predicting fractures following transplant...
April 4, 2018: Archives of Osteoporosis
https://www.readbyqxmd.com/read/29593808/evaluation-of-the-validity-of-treatment-decisions-based-on-surrogate-country-models-before-introduction-of-the-polish-frax-and-recommendations-in-comparison-to-current-practice
#10
Wojciech M Glinkowski, Jerzy Narloch, Bożena Glinkowska, Małgorzata Bandura
Introduction: Patients diagnosed before the Polish FRAX was introduced may require re-evaluation and treatment changes if the diagnosis was established according to a surrogate country FRAX score. The aim of the study was to evaluate the validity of treatment decisions based on the surrogate country model before introduction of the Polish FRAX and to provide recommendations based on the current practice. Material and methods: We evaluated a group of 142 postmenopausal women (70...
March 2018: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/29583083/postmenopausal-osteoporosis-a-clinical-review
#11
Nelson B Watts
In postmenopausal women, osteoporotic fractures are more common than stroke, myocardial infarction, and breast cancer combined, and fractures can be costly and result in disability or death. Because there are no signs or symptoms of osteoporosis other than fracture, risk assessment is necessary to identify those at higher risk for clinical events. For women, a clinical fracture risk assessment (FRAX) is appropriate at menopause. Bone mineral density (BMD) measurement is recommended for women at age 65, and earlier for those who have risk factors...
March 27, 2018: Journal of Women's Health
https://www.readbyqxmd.com/read/29578195/assessment-of-osteoporotic-fracture-risk-in-urban-indian-population-using-quantitative-ultrasonography-frax-tool
#12
Raju Vaishya, Vipul Vijay, Amit K Agarwal, Prashant Maheshwari
Background & objectives: There have been studies around the world on the prevalence of osteoporosis and its related risk factors, but there have been limited studies on risk factors and osteoporosis in the Indian population. In this study, the incidence of osteoporosis and the associated clinical risk factors (CRFs) were studied in the urban Indian population. Methods: Bone mineral density of 445 individuals >38 yr of age using qualitative ultrasound (QUS) was assessed...
November 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29528866/the-utility-and-limitations-of-using-trabecular-bone-score-with-frax
#13
Patrick Martineau, William D Leslie
PURPOSE OF REVIEW: Trabecular bone score (TBS) is a texture index derived from the lumbar spine dual-energy X-ray absorptiometry which can assess skeletal quality and provide information about fracture risk independent of bone mineral density (BMD). TBS is useful in assessing osteoporotic fracture risk, with lower TBS values associated with increased fracture risk. In this article, we review the current state of TBS, including its utility and limitations in the assessment and management of osteoporosis, with particular emphasis on the recent literature...
March 9, 2018: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29526781/comparison-of-femoral-strength-and-fracture-risk-index-derived-from-dxa-based-finite-element-analysis-for-stratifying-hip-fracture-risk-a-cross-sectional-study
#14
Shuman Yang, Yunhua Luo, Lang Yang, Enrico Dall'Ara, Richard Eastell, Andrew L Goertzen, Eugene V McCloskey, William D Leslie, Lisa M Lix
BACKGROUND: Dual-energy X-ray absorptiometry (DXA)-based finite element analysis (FEA) has been studied for assessment of hip fracture risk. Femoral strength (FS) is the maximum force that the femur can sustain before its weakest region reaches the yielding limit. Fracture risk index (FRI), which also considers subject-specific impact force, is defined as the ratio of von Mises stress induced by a sideways fall to the bone yield stress over the proximal femur. We compared risk stratification for prior hip fracture using FS and FRI derived from DXA-based FEA...
March 8, 2018: Bone
https://www.readbyqxmd.com/read/29480960/management-of-patients-with-high-baseline-hip-fracture-risk-by-frax-reduces-hip-fractures-a-post-hoc-analysis-of-the-scoop-study
#15
Eugene McCloskey, Helena Johansson, Nicholas C Harvey, Lee Shepstone, Elizabeth Lenaghan, Ric Fordham, Ian Harvey, Amanda Howe, Cyrus Cooper, Shane Clarke, Neil Gittoes, Alison Heawood, Richard Holland, Tarnya Marshall, Terence W O'Neill, Tim J Peters, Niamh Redmond, David Torgerson, John A Kanis
The SCreening for Osteoporosis in Older women for the Prevention of fracture [SCOOP] study was a community-based screening intervention, in women aged 70 to 85 years in the UK. In the screening arm, licensed osteoporosis treatments were recommended in women identified to be at high risk of hip fracture using the FRAX risk assessment tool (including BMD measurement). In the control arm, standard care was provided. Screening led to a 28% reduction in hip fractures over 5 years. In this planned post hoc analysis, we wished to examine for interactions between screening effectiveness on fracture outcome (any, osteoporotic and hip fractures) on the one hand and baseline FRAX 10-year probability of hip fracture on the other...
February 26, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29475929/effect-of-androgen-deprivation-therapy-on-bone-mineral-density-in-japanese-patients-with-prostate-cancer
#16
Yoshiyuki Miyazawa, Yoshitaka Sekine, Takahiro Syuto, Masashi Nomura, Hidekazu Koike, Hiroshi Matsui, Yasuhiro Shibata, Kazuto Ito, Kazuhiro Suzuki
BACKGROUND/AIM: To evaluate bone mineral density (BMD) in Japanese patients with prostate cancer (PCa) after administering androgen deprivation therapy (ADT) for 2 years. PATIENTS AND METHODS: A total of 84 Japanese patients with PCa were enrolled in this study during the period 2008-2011. BMD was measured by dual energy X-ray absorptiometry, every 6 months. The fracture risk assessment tool (FRAX) score was calculated before starting ADT. We evaluated the change in BMD over a 2-year period and the relationship between this change, the FRAX score, and the estimated glomerular filtration rate (eGFR)...
March 2018: In Vivo
https://www.readbyqxmd.com/read/29470854/the-cost-effectiveness-of-screening-in-the-community-to-reduce-osteoporotic-fractures-in-older-women-in-the-uk-economic-evaluation-of-the-scoop-study
#17
David A Turner, Rebekah Fong Soe Khioe, Lee Shepstone, Elizabeth Lenaghan, Cyrus Cooper, Neil Gittoes, Nicholas C Harvey, Richard Holland, Amanda Howe, Eugene McCloskey, Terence W O'Neill, David Torgerson, Richard Fordham
The SCOOP study was a two-arm randomized controlled trial conducted in the UK in 12,483 eligible women aged 70 to 85 years. It compared a screening program using the FRAX® risk assessment tool in addition to bone mineral density (BMD) measures versus usual management. The SCOOP study found a reduction in the incidence of hip fractures in the screening arm, but there was no evidence of a reduction in the incidence of all osteoporosis-related fractures. To make decisions about whether to implement any screening program, we should also consider whether the program is likely to be a good use of health care resources, ie, is it cost-effective? The cost per gained quality adjusted life year of screening for fracture risk has not previously been demonstrated in an economic evaluation alongside a clinical trial...
February 22, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29469715/assessment-of-risk-and-use-of-prophylaxis-for-glucocorticoidinduced-osteoporosis-among-dermatologists-in-the-pacific-northwest-a-survey-study
#18
Eliza Notaro, Nicole Fett, Michi M Shinohara
OBJECTIVE: Exposure to even physiologic doses of glucocorticoids can reduce one's bone mass and increase risk for osteoporotic fracture. There currently exists a wide variation in clinician approach to the assessment and management of glucocorticoid-induced osteoporosis (GIO). Our objectives were to characterize Pacific Northwest dermatology providers' general practices, assessment of risk for GIO, and preferred GIO prophylaxis measures by way of survey. To identify whether knowledge deficits exist with respect to preventing and managing GIO in dermatology patients...
September 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29468478/does-trabecular-bone-score-tbs-improve-the-predictive-ability-of-frax-%C3%A2-for-major-osteoporotic-fractures-according-to-the-japanese-population-based-osteoporosis-jpos-cohort-study
#19
Junko Tamaki, Masayuki Iki, Yuho Sato, Renaud Winzenrieth, Etsuko Kajita, Sadanobu Kagamimori
This study examined whether bone microarchitecture determined by Trabecular Bone Score (TBS) is associated with the risk of major osteoporotic fractures independent of FRAX® in Japanese women. Participants included 1541 women aged ≥ 40 at baseline. Major osteoporotic fractures during a 10-year follow-up period were documented by the Japanese Population-based Osteoporosis Cohort Study. TBS and areal bone mineral density (aBMD) were calculated for the same spinal regions at baseline. To compare the predictive ability of FRAX® model when used alone versus in combination with TBS, Akaike information criterion (AIC), the area under the receiver operating characteristic curve (AUC), net reclassification improvement (NRI), and integrated discrimination improvement (IDI) were calculated...
February 21, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29463572/frax-tool-underestimates-the-risk-of-osteoporotic-fractures-in-mental-disorders
#20
Rajender R Aparasu, Sanika Rege
No abstract text is available yet for this article.
February 20, 2018: Evidence-based Mental Health
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