Antonino Di Stefano, Isabella Gnemmi, Umberto Rosani, Mauro Maniscalco, Silvestro Ennio D'Anna, Paola Brun, Vitina Carriero, Francesca Bertolini, Bruno Balbi, Fabio Luigi Massimo Ricciardolo
Notch signaling is involved in the prevention of cell differentiation and cell fate in various organs, including the lungs. We aimed to determine the transcriptomic and protein expression of Notch receptors, their ligands, and related transcription factors in stable COPD. The expression and localization of Notch receptors, their ligands, and related transcription factors were measured in bronchial biopsies of individuals with stable mild/moderate (MCOPD) (n = 18) or severe/very severe (SCOPD) (n = 16) COPD, control smokers (CSs) (n = 13), and control nonsmokers (CNSs) (n = 11), and in the lung parenchyma of those with MCOPD (n = 13), CSs (n = 10), and CNSs (n = 10) using immunohistochemistry, ELISA tests, and transcriptome analyses...
March 14, 2024: International Journal of Molecular Sciences