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https://www.readbyqxmd.com/read/28633599/mechanism-of-deltamethrin-induced-thymic-and-splenic-toxicity-in-mice-and-its-protection-by-piperine-and-curcumin-in-vivo-study
#1
Anoop Kumar, Dinakar Sasmal, Neelima Sharma
Deltamethrin (DLM) is a well-known pyrethroid insecticide which is widely used in the agriculture and home pest control due to restriction on the sale of organophosphate. DLM induced apoptosis is well known but its mechanism is still unclear. This study has been designed to find out its mechanism of apoptosis with the help of computational methods along with in vivo methods. The QikProp and ProTox results have shown that DLM has good oral absorption. The docking results reveal that DLM has a strong binding affinity toward the CD4, CD8, CD28 and CD45 receptors...
February 28, 2017: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/28629738/nitrous-oxide-versus-oral-sedation-for-pain-management-of-first-trimester-surgical-abortion-a-randomized-study
#2
Rameet H Singh, Maria Montoya, Eve Espey, Lawrence Leeman
OBJECTIVES: To compare nitrous oxide with oxygen (N2O/O2) to oral hydrocodone/acetaminophen and lorazepam (oral) for analgesia during first-trimester surgical abortion. STUDY DESIGN: This double-blind randomized trial assigned women undergoing first-trimester surgical abortion at<11weeks' gestation to inhaled N2O/O2 vs. oral sedation for pain management. The N2O/O2 group received up to 70:30 ratio during the procedure and placebo pills pre-procedure; the oral group received inhaled oxygen during the procedure and oral hydrocodone/acetaminophen 5mg/325mg and lorazepam 1mg pre-procedure...
June 16, 2017: Contraception
https://www.readbyqxmd.com/read/28622666/real-time-automatic-apneic-event-detection-using-nocturnal-pulse-oximetry
#3
Da Woon Jung, Su Hwan Hwang, Jaegeol Cho, Byung Hun Choi, Hyun Jae Baek, Yu Jin Lee, Do Un Jeong, Kwang Suk Park
OBJECTIVE: Nocturnal pulse oximetry has been proposed as a simpler alternative to polysomnography in diagnosing sleep apnea. However, existing techniques are limited in terms of inability to provide time information on sleep apnea occurrence. This study aimed to propose a new strategy for near real-time automatic detection of apneic events and reliable estimation of apnea-hypopnea index using nocturnal pulse oximetry. METHODS: Among 230 polysomnographic recordings with apnea-hypopnea index values ranging from 0 to 86...
June 14, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28616587/notch-signaling-facilitates-crossing-of-endothelial-barriers-by-tumor-cells
#4
Juan Rodriguez-Vita, Andreas Fischer
Blood vessels supply tumor cells with oxygen and nutrients and provide the basis for metastatic dissemination. In addition, endothelial cells can provide factors that orchestrate the behavior of tumor cells. Here, we expand upon our previous findings that link activation of Notch signaling in the endothelium to cellular senescence, weakening of cell junctions, and expression of adhesion molecules, which facilitates tumor and immune cell migration across the vessel wall and homing at distant sites.
2017: Molecular & Cellular Oncology
https://www.readbyqxmd.com/read/28610674/elevated-serum-d-dimer-level-is-associated-with-an-increased-risk-of-acute-exacerbation-in-interstitial-lung-disease
#5
Genta Ishikawa, Samuel O Acquah, Mary Salvatore, Maria L Padilla
BACKGROUND: Early recognition of patients with interstitial lung disease (ILD) who have an increased risk of developing acute exacerbation (AE) or preclinical AE may be clinically useful, since AE is associated with poor outcome and preventive measures would be of interest to ILD researchers. This study evaluated the relationship between elevated serum D-dimer level (≥0.4 mcg/mL) and subsequent AE or preclinical AE in patients with ILD. METHODS: This single-center, retrospective study was performed from October 2009 through September 2015 in patients with ILD who were ≥18 years old and had idiopathic pulmonary fibrosis, other idiopathic interstitial pneumonias, chronic hypersensitivity pneumonitis, ILD related to collagen tissue disease, or combined pulmonary fibrosis/emphysema...
July 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28600234/rescsrf-algorithm-to-automatically-extract-cheyne-stokes-respiration-features-from-respiratory-signals
#6
Faizan Javed, Henrik Fox
OBJECTIVE: Cheyne-Stokes respiration (CSR) related features are significantly associated with cardiac dysfunction. Scoring of these features is labor-intensive and time-consuming. To automate the scoring process, an algorithm (ResCSRF) has been developed to extract these features from nocturnal measurement of respiratory signals. METHODS: ResCSRF takes 4 signals (nasal flow, thorax, abdomen and finger oxygen saturation) as input. It first detects CSR cycles and then calculates the respiratory features [cyclelength (CL), lung-to-periphery circulation time (LPCT) and time to peak flow (TTPF)]...
June 5, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28597060/-early-bilateral-nephrectomy-in-neonatal-autosomal-recessive-polycystic-kidney-disease-improved-prognosis-or-unnecessary-effort
#7
REVIEW
S Riechardt, M Koch, J Oh, M Fisch
BACKGROUND: Neonatal autosomal recessive polycystic kidney disease (ARPKD) is associated with giant kidneys, lung hypoplasia, pulmonal hypertension, and end-stage renal failure. Depending on the study, mortality is reported to range between 20 and 80%. OBJECTIVES: Does bilateral nephrectomy improve survival? PATIENTS AND METHODS: Between 2010 and 2016, we treated 7 children with prenatally diagnosed ARPKD. All had a planned delivery by cesarean section...
June 8, 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/28587189/roles-of-nicotinamide-adenine-dinucleotide-phosphate-nadph-oxidase-in-angiogenesis-isoform-specific-effects
#8
REVIEW
Haibo Wang, M Elizabeth Hartnett
Angiogenesis is the formation of new blood vessels from preexisting ones and is implicated in physiologic vascular development, pathologic blood vessel growth, and vascular restoration. This is in contrast to vasculogenesis, which is de novo growth of vessels from vascular precursors, or from vascular repair that occurs when circulating endothelial progenitor cells home into an area and develop into blood vessels. The objective of this review is to discuss the isoform-specific role of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) in physiologic and pathologic angiogenesis and vascular repair, but will not specifically address vasculogenesis...
June 3, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28576876/targeting-chronic-myeloid-leukemia-stem-cells-with-the-hypoxia-inducible-factor-inhibitor-acriflavine
#9
Giulia Cheloni, Michele Tanturli, Ignazia Tusa, Ngoc Ho DeSouza, Yi Shan, Antonella Gozzini, Fréderic Mazurier, Elisabetta Rovida, Shaoguang Li, Persio Dello Sbarba
Chronic myeloid leukemia (CML) is a hematopoietic stem cell (HSC)-driven neoplasia characterized by the expression of the constitutively-active tyrosine kinase BCR/Abl. CML therapy based on tyrosine kinase inhibitors (TKi) is highly effective in inducing remission but not in targeting leukemia stem cells (LSC), which sustain minimal residual disease and are responsible for CML relapse following discontinuation of treatment. The identification of molecules capable to target LSC appears therefore of primary importance to aim at CML eradication...
June 2, 2017: Blood
https://www.readbyqxmd.com/read/28572970/home-based-preparation-approaches-altered-the-availability-of-health-beneficial-components-from-carrot-and-blueberry
#10
Boyan Gao, Lu Yu, Jie Liu, Thomas T Y Wang, Yinghua Luo, Liangli Lucy Yu, Huijuan Zhang, Lingxiao Gong, Jing Wang
This study investigated the effects of different home food preparation methods on availability of total phenolic contents (TPC) and radical scavenging components, as well as the selected health beneficial compounds from fresh blueberry and carrot. High performance liquid chromatography (HPLC) analysis revealed that ground carrots using blenders released significantly greater amount of β-carotene than their chopped counterpart, and blueberry samples prepared with different commercial blenders/grinders released different levels of cyaniding-3-O-glucoside and malvidin-3-O-glucoside...
May 2017: Food Science & Nutrition
https://www.readbyqxmd.com/read/28551423/safety-and-predictors-of-next-day-discharge-after-elective-transfemoral-transcatheter-aortic-valve-replacement
#11
Sulaiman Rathore, Yevgeniy Latyshev, Sheree Emore, Joseph Rowe, Jason Foerst
OBJECTIVES: We sought to determine the predictors of next-day discharge (NDD) for selected patients undergoing elective transfemoral transcatheter aortic valve replacement (TF-TAVR). BACKGROUND: Techniques have rapidly evolved over the last several years to simplify TF-TAVR allowing for a subset of patients to be discharged the next day. METHODS: Baseline and procedural characteristics, in-hospital and 30-day follow-up outcomes, complications and readmission rates of 100 TF-TAVR cases were assessed...
May 19, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/28550896/pediatric-near-drowning-events-do-they-warrant-trauma-team-activation
#12
Pranit N Chotai, Lisa Manning, Benjamin Eithun, Joshua C Ross, James W Eubanks, Chad Hamner, Ankush Gosain
BACKGROUND: The purpose of this study was to determine the incidence of traumatic injuries, factors associated with mortality, and need for pediatric trauma surgery involvement for drowning and near-drowning events in children. MATERIALS AND METHODS: An institutional review board-approved, retrospective chart review was performed at three American College of Surgeons-verified Pediatric Trauma Centers (2011-2014). Patients with International Classification of Diseases, Ninth Revision, codes or E-codes for fatal-nonfatal drowning, fall into water, accidental drowning, or submersion were included...
May 15, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28546848/estimation-of-maximal-oxygen-consumption-and-heart-rate-recovery-using-the-tecumseh-sub-maximal-step-test-and-their-relationship-to-cardiovascular-risk-factors
#13
Alun D Hughes, Nish Chaturvedi
BACKGROUND: Maximum aerobic capacity (VO2max) is associated with lower cardiovascular and total mortality. Step tests can be used to provide an estimate of (VO2max) in epidemiological or home-based studies. We compared different methods of estimation of VO2max and heart rate recovery and evaluated the relationship of these estimates with cardiovascular risk factors. METHODS: Data were analysed from 2286 participants in the Tecumseh Community Health Study (>16y and <70y) who performed a step test...
June 2017: Artery Research
https://www.readbyqxmd.com/read/28543396/functional-and-structural-assessment-of-the-effect-of-human-umbilical-cord-blood-mesenchymal-stem-cells-in-doxorubicin-induced-cardiotoxicity
#14
Somia H Abd Allah, Samia Hussein, Mai M Hasan, Raghda H A Deraz, Wafaa F Hussein, Laila M E Sabik
Cardiomyopathy induced by doxorubicin (DOX) was recognized at an early stage and also several years after drug administration. Mesenchymal stem cells (MSCs) have many properties that make them suitable for preventive and/ or regenerative therapies. In this study, we evaluated the effect of MSCs in the functional and the structural improvement of DOX-induced cardiomyopathy in rats. Ninety adult male albino rats were randomly divided into three equal groups of thirty rats each: Group I (control): rats received normal saline...
May 25, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28541941/greywater-treatment-by-granular-filtration-system-using-volcanic-tuff-and-gravel-media
#15
Abeer Albalawneh, Tsun-Kuo Chang, Heba Alshawabkeh
The main objective of this study was to evaluate the efficiency of a granular filtration system (GFS) in greywater treatment under arid and semi-arid conditions. Six GFSs were designed, constructed, and monitored for approximately 13 months. Each GFS served a single rural Jordanian home by treating their greywater. Volcanic tuff media were used as the filtration media in three of the GFSs while the remaining three GFSs used gravel media. Results show that the biological oxygen demand, chemical oxygen demand, and total suspended solids of the effluent were significantly lower as compared to the influent and demonstrated a removal efficiency of 73%, 65%, and 85%, respectively, when using volcanic tuff media...
May 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28536661/successful-use-of-extracorporeal-membrane-oxygenation-for-the-treatment-of-cardiogenic-shock-due-to-scorpion-envenomation
#16
Amine Tarmiz, Imene Mgarrech, Chokri Kortas, Sofiane Jerbi
Introduction. The occurrence of a cardiogenic shock is a rare presentation after scorpion envenomation. The treatment includes classically the use of inotropes and specific vasodilators. Case Presentation. We report a case of an 11-year-old boy presenting with cardiogenic shock and pulmonary edema after a scorpion sting. Despite adequate management at the emergency department and intensive care unit, the patient's hemodynamic status worsened rapidly, justifying his transfer to our department for ventricular mechanical assistance by venoarterial extracorporeal membrane oxygenation...
2017: Case Reports in Critical Care
https://www.readbyqxmd.com/read/28528348/effect-of-home-noninvasive-ventilation-with-oxygen-therapy-vs-oxygen-therapy-alone-on-hospital-readmission-or-death-after-an-acute-copd-exacerbation-a-randomized-clinical-trial
#17
Patrick B Murphy, Sunita Rehal, Gill Arbane, Stephen Bourke, Peter M A Calverley, Angela M Crook, Lee Dowson, Nicholas Duffy, G John Gibson, Philip D Hughes, John R Hurst, Keir E Lewis, Rahul Mukherjee, Annabel Nickol, Nicholas Oscroft, Maxime Patout, Justin Pepperell, Ian Smith, John R Stradling, Jadwiga A Wedzicha, Michael I Polkey, Mark W Elliott, Nicholas Hart
Importance: Outcomes after exacerbations of chronic obstructive pulmonary disease (COPD) requiring acute noninvasive ventilation (NIV) are poor and there are few treatments to prevent hospital readmission and death. Objective: To investigate the effect of home NIV plus oxygen on time to readmission or death in patients with persistent hypercapnia after an acute COPD exacerbation. Design, Setting, and Participants: A randomized clinical trial of patients with persistent hypercapnia (Paco2 >53 mm Hg) 2 weeks to 4 weeks after resolution of respiratory acidemia, who were recruited from 13 UK centers between 2010 and 2015...
June 6, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28528221/bronchopulmonary-dysplasia-and-perinatal-characteristics-predict-1-year-respiratory-outcomes-in-newborns-born-at-extremely-low-gestational-age-a-prospective-cohort-study
#18
Roberta L Keller, Rui Feng, Sara B DeMauro, Thomas Ferkol, William Hardie, Elizabeth E Rogers, Timothy P Stevens, Judith A Voynow, Scarlett L Bellamy, Pamela A Shaw, Paul E Moore
OBJECTIVE: To assess the utility of clinical predictors of persistent respiratory morbidity in extremely low gestational age newborns (ELGANs). STUDY DESIGN: We enrolled ELGANs (<29 weeks' gestation) at ≤7 postnatal days and collected antenatal and neonatal clinical data through 36 weeks' postmenstrual age. We surveyed caregivers at 3, 6, 9, and 12 months' corrected age to identify postdischarge respiratory morbidity, defined as hospitalization, home support (oxygen, tracheostomy, ventilation), medications, or symptoms (cough/wheeze)...
May 17, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28526665/the-sensor-study-protocol-for-a-mixed-methods-study-of-self-management-checks-to-predict-exacerbations-of-pseudomonas-aeruginosa-in-patients-with-long-term-respiratory-conditions
#19
Claire Roberts, Thomas L Jones, Samal Gunatilake, Will Storrar, Scott Elliott, Sharon Glaysher, Ben Green, Steven Rule, Carole Fogg, Ann Dewey, Kevin A Auton, Anoop J Chauhan
BACKGROUND: There are an estimated three million people in the United Kingdom with chronic obstructive pulmonary disease (COPD), and the incidence of bronchiectasis is estimated at around 0.1% but is more common in COPD and severe asthma. Both COPD and bronchiectasis are characterized by exacerbations in which bacteria play a central role. Pseudomonas aeruginosa is isolated from sputum samples from 4% to 15% of adults with COPD and is more likely to be isolated from patients with severe disease...
May 19, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28518009/aeromedical-evacuation-using-extra-corporeal-life-support-after-resuscitated-cardiac-arrest
#20
David Gerard, Hervé Raffin, Guillaume Lebreton
BACKGROUND: Extra corporeal life support (ECLS) is presently first line therapy for refractory cardiogenic shock. Mobile circulatory support teams implant ECLS or extra corporeal membrane oxygenation (ECMO) in patients in the hospital without circulatory support. These patients are then transported to specialized centers. Here we report a case of sending a mobile circulatory support team abroad, followed by air ambulance evacuation, which, to our knowledge, has never been used as part of medical assistance abroad...
April 1, 2017: Aerospace Medicine and Human Performance
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