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https://www.readbyqxmd.com/read/28742114/a-unique-polysaccharide-purified-from-hericium-erinaceus-mycelium-prevents-oxidative-stress-induced-by-h2o2-in-human-gastric-mucosa-epithelium-cell
#1
Mingxing Wang, Nakajima Kanako, Yanqiu Zhang, Xulang Xiao, Qipin Gao, Konishi Tetsuya
Hericium erinaceus (HE) has been used both as a traditional Chinese medicine and home remedy for treatment of gastric and duodenal ulcers and gastritis. EP-1, a purified polysaccharide isolated from HE mycelium, has recently been identified as the active component responsible for HE anti-gastritis activity. Because oxidative stress has been implicated as a pathogenic cause of gastritis and gastric ulcers, EP-1 antioxidant properties were systematically examined in vitro using the human gastric mucosal epithelial cell line, GES-1...
2017: PloS One
https://www.readbyqxmd.com/read/28739569/normal-carboxyhaemoglobin-level-in-carbon-monoxide-poisoning-treated-with-hyperbaric-oxygen-therapy
#2
Scott A Helgeson, Michael E Wilson, Pramod K Guru
Throughout the world both intentional and inadvertent exposure to carbon monoxide (CO) remains an important public health issue. While CO poisoning can be lethal, the morbidity is predominantly due to nervous system injury. A previously healthy 22-year-old woman was found unconscious at home by her sister. Her parents were found dead in the house with a recent history of a dysfunctional furnace. She was presumed to have CO poisoning despite an initial carboxyhaemoglobin level of 2.5%. Patient had both clinical and radiological evidence of neurological damage...
July 24, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28727596/intraoperative-acute-multivessel-coronary-vasospasm-in-cardiac-allograft-a-case-report
#3
Richard Sheu, Kathleen Berfield, Stephanie Jones, Jay Pal, G Burkhard Mackensen
We present a patient who developed acute intraoperative cardiac failure requiring open cardiac message immediately after uncomplicated heart transplantation. After successful resuscitation and establishment of extracorporeal membrane oxygenation, coronary angiography showed diffuse multivessel coronary vasospasm, which responded to intracoronary and IV administration of vasodilators. Cardiac function gradually improved and the patient was discharged home after a prolonged hospital course. Cardiac allograft dysfunction associated with coronary vasospasm immediately after heart transplantation has not previously been reported...
July 19, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/28718318/high-glucose-induced-endothelial-progenitor-cell-dysfunction
#4
Hongyan Kang, Xuejiao Ma, Jiajia Liu, Yubo Fan, Xiaoyan Deng
Vascular complications contribute significantly to morbidity and mortality of diabetes mellitus. The primary cause of vascular complications in diabetes mellitus is hyperglycaemia, associated with endothelial dysfunction and impaired neovascularization. Circulating endothelial progenitor cells was shown to play important roles in vascular repair and promoting neovascularization. In this review, we will demonstrate the individual effect of high glucose on endothelial progenitor cells. Endothelial progenitor cells isolated from healthy subjects exposed to high glucose conditions or endothelial progenitor cells isolated from diabetic patients exhibit reduced number of endothelial cell colony forming units, impaired abilities of differentiation, proliferation, adhesion and migration, tubulization, secretion, mobilization and homing, whereas enhanced senescence...
July 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28714534/adjustable-thermoplastic-oral-appliance-versus-positive-airway-pressure-for-obstructive-sleep-apnea
#5
Wish Banhiran, Paraya Assanasen, Cherdchai Nopmaneejumrudlers, Nongyoaw Nujchanart, Wimontip Srechareon, Cheerasook Chongkolwatana, Choakchai Metheetrairut
OBJECTIVES/HYPOTHESIS: To compare outcomes of continuous positive airway pressure (CPAP) and the adjustable thermoplastic mandibular advancement splint (AT-MAS) for obstructive sleep apnea treatment. STUDY DESIGN: Randomized crossover, noninferiority, tertiary center setting. METHODS: Fifty patients with a mean age of 49.5 ± 10.6 years were enrolled. Inclusion criteria were age ≥18 years, apnea-hypopnea index (AHI) ≥5 events/hour, and oxygen saturation ≥70%...
July 17, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28712082/biological-nutrient-recovery-from-culturing-of-pearl-gourami-trichogaster-leerii-by-cherry-tomato-solanum-lycopersicum-in-aquaponic-system
#6
Shima Makhdom, Seyed Pezhman Hosseini Shekarabi, Mehdi Shamsaie Mehrgan
The possibility of using different densities of cherry tomato as a bio-filter in a simple media-based aquaponic system to recycle nutrients from pearl gourami intensive culture wastewater was evaluated. Water quality parameters including total ammonia nitrogen (TAN), nitrite (NO2(-)), nitrate (NO3(-)), phosphate (PO4(3-)), pH, and dissolved oxygen (DO) were determined in outlet of the aquaponic system during a 60-day experimental period. Cherry tomato was planted at four densities of 0 (control), 3 (T1), 6 (T2), and 9 (T3) plants per aquaponic unit with a constant fish stock density...
July 15, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28711234/sleep-related-breathing-disorders-and-indications-for-polysomnography-in-preterm-infants
#7
Koen Joosten, Robbin de Goederen, Angelique Pijpers, Karel Allegaert
There is a range of breathing problems which occur and may persist in preterm infants, such as central apneas, obstructive apneas and periodic breathing. Preterm infants may also suffer from respiratory distress syndrome and chronic lung disease necessitating prolonged use of oxygen therapy after discharge from the hospital. Due to these persistent breathing pattern abnormalities in preterm infants, there is a higher risk of altered sleep and apparent life threatening events. Polysomnography can be a helpful tool to identify those infants who have abnormalities in their breathing pattern, to identify those infants who have an increased risk to get a sleep related breathing event at home and to decide about the discontinuation of oxygen therapy...
July 12, 2017: Early Human Development
https://www.readbyqxmd.com/read/28709511/erectile-dysfunction-is-independently-associated-with-apnea-hypopnea-index-and-oxygen-desaturation-index-in-elderly-but-not-younger-community-dwelling-men
#8
Sean A Martin, Sarah L Appleton, Robert J Adams, Anne W Taylor, Andrew Vincent, Nicholas R Brook, Peter G Catcheside, Andrew Vakulin, R Douglas McEvoy, Nick A Antic, Gary A Wittert
OBJECTIVE(S): To examine the association between obstructive sleep apnea (OSA) and other sleep indices using polysomnography (PSG) data and erectile dysfunction (ED) in a representative cohort of men. DESIGN: Cross-sectional. SETTING: Community-based. PARTICIPANTS: Aged 40+ years (n=734; mean age [SD], 60.8 [10.9]). MEASUREMENTS: Men with no prior OSA diagnosis who underwent in-home PSG (Embletta X100; 2010-11) and ED assessment (Global Impotence Rating) were selected...
August 2017: Sleep Health
https://www.readbyqxmd.com/read/28688160/unilateral-vocal-cord-paralysis-after-surgical-closure-of-a-patent-ductus-arteriosus-in-extremely-preterm-infants
#9
Pramod Pharande, Sathiyapriya Karthigeyan, Karen Walker, Daphne D'Cruz, Nadia Badawi, Melissa Luig, David Winlaw, Himanshu Popat
AIM: Left vocal cord paralysis (LVCP) is variably reported post ligation of patent ductus arteriosus (PDA). Our objective was to determine the incidence of LVCP and identify predictive factors and associated morbidities in preterm infants post PDA ligation. METHODS: This is a retrospective cohort study of infants less than 29 weeks gestational age from 2006 to 2014 who underwent PDA ligation. Infants with laryngeal symptoms underwent flexible fibreoptic nasopharyngolaryngoscopy to evaluate vocal cord function...
July 8, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/28680379/diclofenac-inhibits-27-hydroxycholesterol-induced-differentiation-of-monocytic-cells-into-mature-dendritic-cells
#10
Yonghae Son, Bo-Young Kim, Young Chul Park, Koanhoi Kim
We investigated whether diclofenac could influence the development of antigen-presenting cells in an oxygenated cholesterol-rich environment by determining its effects on the 27-hydroxycholesterol (27OHChol)-induced differentiation of monocytic cells into mature dendritic cells (mDCs). Treatment of human THP-1 monocytic cells with diclofenac antagonized the effects of 27OHChol by attenuating dendrite formation and cell attachment and promoting endocytic function. Diclofenac inhibited the transcription and surface expression of the mDC markers of CD80, CD83, and CD88, and reduced the 27OHChol-induced elevation of surface levels of MHC class I and II molecules to the basal levels in a dose-dependent manner...
June 2017: Immune Network
https://www.readbyqxmd.com/read/28673796/sleep-disordered-breathing-in-enuretic-children-and-controls
#11
Ingrid Jönson Ring, Agneta Markström, Farhan Bazargani, Tryggve Nevéus
INTRODUCTION: Nocturnal enuresis and sleep disordered breathing are common childhood problems that are reported to be associated with each other. Sleep disordered breathing is often found in children with upper airway obstruction and, according to some studies, its presence is associated with an increased risk of nocturnal enuresis. Respiration during sleep in children with therapy-resistant enuresis, but no history of snoring or sleep apneas, has previously been investigated, and subclinical signs of disordered respiration were found in this group...
June 16, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28668090/informal-caregivers-experience-of-supplemental-oxygen-in-pulmonary-fibrosis
#12
Bridget A Graney, Frederick S Wamboldt, Susan Baird, Tara Churney, Kaitlin Fier, Marjorie Korn, Mark McCormick, Thomas Vierzba, Jeffrey J Swigris
BACKGROUND: Patients prescribed supplemental oxygen (O2) therapy face challenges as they adjust to being constantly "tethered" to an oxygen delivery device. Informal caregivers (ICs) of patients with pulmonary fibrosis (PF) face their own, often overlooked hardships when O2 is brought into their home and added to their lives. Our aim was to understand the multiple effects of supplemental oxygen therapy on ICs of patients with PF. METHODS: We conducted single, semi-structured telephone interviews with twenty ICs of patients with PF who were using O2 for at least 8 months...
July 1, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28665066/comparison-of-follow-up-courses-after-discharge-from-neonatal-intensive-care-unit-between-very-low-birth-weight-infants-with-and-without-home-oxygen
#13
Ji Sook Kim, Jae Won Shim, Jang Hoon Lee, Yun Sil Chang
In order to investigate the clinical impact of home oxygen use for care of premature infants, we compared the follow-up courses after neonatal intensive care unit (NICU) discharge between very low birth weight infants (VLBWIs) with and without home oxygen. We retrospectively identified 1,232 VLBWIs born at 22 to 32 weeks of gestation, discharged from the NICU of 43 hospitals in Korea between April 2009 and March 2010, and followed them up until April 2011. Clinical outcomes, medical service uses, and readmission and death rates during follow-up after the NICU discharge were compared between VLBWIs with (HO, n = 167) and those without (CON, n = 1,056) home oxygen at discharge...
August 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28661900/palliative-care-and-interstitial-lung-disease
#14
Sabrina Bajwah, Janelle Yorke
PURPOSE OF REVIEW: The palliative care needs of people with interstitial lung disease (ILD) have recently been highlighted by the National Institute for Health and Care Excellence. All people with progressive ILD should receive best supportive care to improve symptom control and quality of life and where possible this should be evidence based. RECENT FINDINGS: Deaths from ILD are increasing and deaths in hospital are more common compared to home. People with ILD experience a wide range of symptoms including breathlessness and cough...
June 28, 2017: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/28659997/24-hour-hypoxia-and-pulmonary-hypertension-in-patients-with-idiopathic-pulmonary-fibrosis
#15
Marcelo P Rodrigues, Carolina M Vissoci, Samuel P Rosa, Sandra B C Negreiros
BACKGROUND: The quantification of hypoxia based on resting partial pressure of arterial oxygen (PaO2) may underestimate hypoxia related to activities of daily living or sleep and thus not accurately reflect pulmonary hypertension (PH). The aim of the present study was to investigate the association of resting PaO2 with percent time of SpO2 below 90% (T90) and 88% (T88) in 24 hours. We also evaluated the capacity of hypoxia measures to predict PH in patients with idiopathic pulmonary fibrosis (IPF)...
2017: Open Respiratory Medicine Journal
https://www.readbyqxmd.com/read/28643616/advanced-neuroimaging-of-carbon-monoxide-poisoning
#16
Marco Varrassi, Alessandra Di Sibio, Camilla Gianneramo, Marco Perri, Giorgia Saltelli, Alessandra Splendiani, Carlo Masciocchi
Carbon monoxide (CO) inhalation is nowadays the most common cause of fatal poisoning worldwide. CO binds to haemoglobin 230-270 times more avidly than oxygen, thus leading to formation of carboxyhaemoglobin with subsequent reduction of tissue oxygenation. Brain is mainly affected due to its high oxygen requirement. Up to two-thirds of patients who survive the acute phase of this pathology present a delayed leukoencephalopathy, usually in a period ranging from two to 40 days. White matter damage closely relates to long-term prognosis of these patients...
January 1, 2017: Neuroradiology Journal
https://www.readbyqxmd.com/read/28634972/predictors-of-re-exacerbation-after-an-index-exacerbation-of-chronic-obstructive-pulmonary-disease-in-the-reduce-randomised-clinical-trial
#17
Brigitte Engel, Christian Schindler, Jörg D Leuppi, Jonas Rutishauser
BACKGROUND: Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) compromise physical activity and quality of life and contribute significantly to health care costs. Systemic glucocorticoids benefit clinical outcome in AECOPD, and the REDUCE trial demonstrated noninferiority of a 5-day treatment course with prednisone compared with 14 days therapy regarding clinical outcome over 6 months of follow-up. Unexpectedly, we found an inverse correlation between circulating cortisol levels and exacerbation risk during a 6-month follow-up period...
June 21, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28633599/mechanism-of-deltamethrin-induced-thymic-and-splenic-toxicity-in-mice-and-its-protection-by-piperine-and-curcumin-in-vivo-study
#18
Anoop Kumar, Dinakar Sasmal, Neelima Sharma
Deltamethrin (DLM) is a well-known pyrethroid insecticide which is widely used in the agriculture and home pest control due to restriction on the sale of organophosphate. DLM induced apoptosis is well known but its mechanism is still unclear. This study has been designed to find out its mechanism of apoptosis with the help of computational methods along with in vivo methods. The QikProp and ProTox results have shown that DLM has good oral absorption. The docking results reveal that DLM has a strong binding affinity toward the CD4, CD8, CD28 and CD45 receptors...
February 28, 2017: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/28629738/nitrous-oxide-versus-oral-sedation-for-pain-management-of-first-trimester-surgical-abortion-a-randomized-study
#19
Rameet H Singh, Maria Montoya, Eve Espey, Lawrence Leeman
OBJECTIVE: The objective of the study was to compare nitrous oxide with oxygen (N2O/O2) to oral hydrocodone/acetaminophen and lorazepam for analgesia during first-trimester surgical abortion. STUDY DESIGN: This double-blind randomized trial assigned women undergoing first-trimester surgical abortion at<11 weeks' gestation to inhaled N2O/O2 vs. oral sedation for pain management. The N2O/O2 group received up to 70:30 ratio during the procedure and placebo pills preprocedure; the oral group received inhaled oxygen during the procedure and oral hydrocodone/acetaminophen 5 mg/325 mg and lorazepam 1 mg preprocedure...
June 16, 2017: Contraception
https://www.readbyqxmd.com/read/28622666/real-time-automatic-apneic-event-detection-using-nocturnal-pulse-oximetry
#20
Da Woon Jung, Su Hwan Hwang, Jaegeol Cho, Byung Hun Choi, Hyun Jae Baek, Yu Jin Lee, Do Un Jeong, Kwang Suk Park
OBJECTIVE: Nocturnal pulse oximetry has been proposed as a simpler alternative to polysomnography in diagnosing sleep apnea. However, existing techniques are limited in terms of inability to provide time information on sleep apnea occurrence. This study aimed to propose a new strategy for near real-time automatic detection of apneic events and reliable estimation of apnea-hypopnea index using nocturnal pulse oximetry. METHODS: Among 230 polysomnographic recordings with apnea-hypopnea index values ranging from 0 to 86...
June 14, 2017: IEEE Transactions on Bio-medical Engineering
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