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https://www.readbyqxmd.com/read/27933242/transtuzumab-induced-organizing-pneumonia-a-case-report
#1
Ajay Gupta, Louise Teo, Philip Masel, David Godbolt, Geoffrey Beadle
BACKGROUND: Patients with metastatic breast cancer often have pulmonary symptoms with varying aetiologies. Transtuzumab is an extremely important drug used in the treatment of Her 2 neu over-expressing breast cancers. In this report we describe a case of organizing pneumonia associated with use of transtuzumab in metastatic breast cancer. Only three such cases have previously been reported. CASE DESCRIPTION: A 43 year old lady with Her 2 neu 3+, estrogen and progesterone receptor positive, metastatic breast cancer was started on weekly transtuzumab and albumen bound paclitaxel...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27921430/-obstructive-sleep-apnoea-and-type-2-diabetes-mellitus
#2
Andrea Plíhalová, Kateřina Westlake, Jan Polák
Obstructive sleep apnoea syndrome (OSA) is a disease very frequently occurring in people with type 2 diabetes, that significantly increases cardiovascular morbidity and mortality. In a number of studies, OSA has been identified as an independent risk factor for the development of insulin resistance, glucose intolerance and type 2 diabetes mellitus. Disorders of glucose homeostasis in patients with OSA are probably mediated by chronic intermittent hypoxia and/or sleep fragmentation through activation of the sympathetic nervous system, the hypothalamic-pituitary-adrenal stress axis, pro-inflammatory paths or oxidative stress...
2016: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/27908464/effects-of-different-duration-exercise-programs-in-children-with-severe-burns
#3
Robert P Clayton, Paul Wurzer, Clark R Andersen, Ronald P Mlcak, David N Herndon, Oscar E Suman
INTRODUCTION: Burns lead to persistent and detrimental muscle breakdown and weakness. Standard treatment at our institution includes a voluntary 12-week rehabilitative exercise program to limit and reverse the effects of increased muscle catabolism. In the present work, we investigated if different durations of exercise, 6 or 12 weeks, produce comparable improvements in muscle strength, body composition, and cardiopulmonary fitness. METHODS: We prospectively enrolled and randomized patients with ≥30% total body surface area (TBSA) burned to receive 6 or 12 weeks of exercise rehabilitation...
November 28, 2016: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/27886372/oxygen-for-breathlessness-in-patients-with-chronic-obstructive-pulmonary-disease-who-do-not-qualify-for-home-oxygen-therapy
#4
REVIEW
Magnus Ekström, Zainab Ahmadi, Anna Bornefalk-Hermansson, Amy Abernethy, David Currow
BACKGROUND: Breathlessness is a cardinal symptom of chronic obstructive pulmonary disease (COPD). Long-term oxygen therapy (LTOT) is given to improve survival time in people with COPD and severe chronic hypoxaemia at rest. The efficacy of oxygen therapy for breathlessness and health-related quality of life (HRQOL) in people with COPD and mild or no hypoxaemia who do not meet the criteria for LTOT has not been established. OBJECTIVES: To determine the efficacy of oxygen versus air in mildly hypoxaemic or non-hypoxaemic patients with COPD in terms of (1) breathlessness; (2) HRQOL; (3) patient preference whether to continue therapy; and (4) oxygen-related adverse events...
November 25, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27884081/a-randomized-cross-over-study-comparing-the-efficacy-of-two-mandibular-advancement-appliances-in-the-treatment-of-mild-moderate-obstructive-sleep-apnea
#5
Ayman Al-Dharrab
OBJECTIVE: To compare efficacy, side effects, patient compliance, and preference between two types of custom-made mandibular advancement appliances (MAAs) in the treatment of patients with mild to moderate obstructive sleep apnea (OSA). METHODOLOGY: This prospective, randomized, crossover study of 12 patients with mild to moderate OSA compared a titratable and a non-titratable MAA. Each patient was fitted with both appliances in a random order with a washout period of two weeks...
November 24, 2016: Cranio: the Journal of Craniomandibular Practice
https://www.readbyqxmd.com/read/27879026/ionizing-radiation-promotes-ccl27-secretion-from-keratinocytes-through-the-cross-talk-between-tnf-%C3%AE-and-ros
#6
Qian Zhang, Linlin Zhu, Gang Wang, Ye Zhao, Na Xiong, Hegang Bao, Wensen Jin
The skin-associated chemokine CCL27 and its receptor CCR10 mediate the immune response of skin-homing T cells. The CCL27 secreted from keratinocytes was reportedly involved in inflammatory skin diseases such as atopic dermatitis, contact dermatitis, and psoriasis. However, whether ionizing radiation increases the levels of CCL27 secretion still remains unclear. In HaCaT cells, a human keratinocyte cell line, CCL27 secretion was markedly increased after X-ray irradiation. We further found that irradiation boosted the generation of reactive oxygen species (ROS), which was concomitant with the release of tumor necrosis factor-alpha (TNF-α)...
November 23, 2016: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/27877098/accidental-epidural-injection-of-rocuronium-in-a-pediatric-patient-a-case-report-and-literature-review
#7
Ting-Ting Wu, David S Hoff
Accidental administration of non-epidural drugs into the epidural or subarachnoid spaces may be associated with unexpected pain, morbidity, adverse effects, increased level of care, prolonged hospital stay, and mortality. We describe a 12-month-old admitted for secondary-stage hypospadias reconstruction. General anesthesia was induced with sevofiurane and a peripheral catheter was placed. Instead of ropivacaine, rocuronium (80 mg; 6.3 mg/kg) was injected into the epidural space by the caudal route. Surgery was uneventful and was completed 160 minutes after rocuronium was given...
September 2016: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/27865213/phenotypic-correction-of-fanconi-anemia-cells-in-the-murine-bone-marrow-after-carrier-cell-mediated-delivery-of-lentiviral-vector
#8
Santhosh Chakkaramakkil Verghese, Natalya A Goloviznina, Peter Kurre
Fanconi anemia (FA) is an autosomal-recessive disorder associated with hematopoietic failure and it is a candidate for hematopoietic stem cell (HSC)-directed gene therapy. However, the characteristically reduced HSC numbers found in FA patients, their ineffective mobilization from the marrow, and re-oxygenation damage during ex vivo manipulation have precluded clinical success using conventional in vitro approaches. We previously demonstrated that lentiviral vector (LV) particles reversibly attach to the cell surface where they gain protection from serum complement neutralization...
November 19, 2016: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/27852427/monitoring-the-hospital-management-of-acute-asthma-the-italian-pediatric-network-experience
#9
A G Martelli, R Bianchi, B Boldrighini, M Bosoni, A De Vuono, A Flores D'Arcais, G Gargantini, R Longhi, M T Ortisi, E Racchi, L Parola
BACKGROUND: The Study Group on Accreditation and Quality Improvement of the Italian Society of Pediatrics has developed an observational study about the hospital management of pediatric patients affected by severe asthma, in order to evaluate how the Guidelines for severe asthma in childhood are applied in the daily practice. METHODS: This study included patients between 2 and 17 years, hospitalized or under short intensive observation for acute asthma. The data collection was carried out through the compilation of on-line forms...
November 2016: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27849657/long-term-follow-up-on-health-related-quality-of-life-after-mechanical-circulatory-support-in-children
#10
Thilo P K Fleck, Georg Dangel, Felix Bächle, Christoph Benk, Jochen Grohmann, Johannes Kroll, Matthias Siepe, Rene Höhn, Janbernd Kirschner, Friedhelm Beyersdorf, Brigitte Stiller
OBJECTIVE: The objective of this study was to evaluate health-related quality of life in long-term survivors of mechanical circulatory support after acute cardiopulmonary failure. DESIGN: Prospective follow-up study. SETTING: Single-institutional in a center for congenital heart disease and pediatric cardiology. PATIENTS: Fifty patients who underwent 58 mechanical circulatory support therapies in our institution from 2001 to 2012...
November 15, 2016: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/27832989/risk-stratification-for-the-development-of-respiratory-adverse-events-following-vascular-surgery-using-the-society%C3%A2-of-vascular-surgery-s-vascular-quality-initiative
#11
Elizabeth A Genovese, Larry Fish, Rabih A Chaer, Michel S Makaroun, Donald T Baril
OBJECTIVE: Postoperative respiratory adverse events (RAEs) are associated with high rates of morbidity and mortality in general surgery, however, little is known about these complications in the vascular surgery population, a frail subset with multiple comorbidities. The objective of this study was to describe the contemporary incidence of RAEs in vascular surgery patients, the risk factors for this complication, and the overall impact of RAEs on patient outcomes. METHODS: The Vascular Quality Initiative was queried (2003-2014) for patients who underwent endovascular abdominal aortic repair, open abdominal aortic aneurysm repair, thoracic endovascular aortic repair, suprainguinal bypass, or infrainguinal bypass...
November 7, 2016: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/27826097/oxidative-stress-drives-cd8-t-cell-skin-trafficking-in-patients-with-vitiligo-through-cxcl16-upregulation-by-activating-the-unfolded-protein-response-in-keratinocytes
#12
Shuli Li, Guannan Zhu, Yuqi Yang, Zhe Jian, Sen Guo, Wei Dai, Qiong Shi, Rui Ge, Jingjing Ma, Ling Liu, Kai Li, Qi Luan, Gang Wang, Tianwen Gao, Chunying Li
BACKGROUND: In patients with vitiligo, an increased reactive oxygen species (ROS) level has been proved to be a key player during disease initiation and progression in melanocytes. Nevertheless, little is known about the effects of ROS on other cells involved in the aberrant microenvironment, such as keratinocytes and the following immune events. CXCL16 is constitutively expressed in keratinocytes and was recently found to mediate homing of CD8(+) T cells in human skin. OBJECTIVE: We sought to explicate the effect of oxidative stress on human keratinocytes and its capacity to drive CD8(+) T-cell trafficking through CXCL16 regulation...
November 5, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27822310/anaphylactic-shock-during-cement-implantation-of-a-total-hip-arthroplasty-in-a-patient-with-underlying-mastocytosis-case-report-of-a-rare-intraoperative-complication
#13
Anita Ten Hagen, Pieter Doldersum, Tom van Raaij
BACKGROUND: Cemented total hip arthroplasty (THA) is a safe and common procedure. In rare cases life threatening bone cement implantation syndrome (BCIS) may occur, which is commonly caused by pulmonary embolism (PE). CASE PRESENTATION: We describe the rare case of a 70-year old patient who underwent an elective total hip replacement. Before surgery he was diagnosed with underlying systemic indolent mastocytosis, a rare pathological disorder that may result in anaphylaxis after massive systemic mast cell activation...
2016: Patient Safety in Surgery
https://www.readbyqxmd.com/read/27818328/clinical-features-of-smokers-with-radiological-emphysema-but-without-airway-limitation
#14
Ana B Alcaide, Pablo Sanchez, Gorka Bastarrika, Arantza Campo, Juan Berto, Maria Del Mar Ocon, Bartolome R Celli, Javier J Zulueta, Juan P de-Torres
RATIONALE: The clinical characteristics of patients with emphysema but without airway limitation remain unknown. OBJECTIVE: To compare the clinical features of current and former smokers without airflow limitation who have radiological emphysema on chest CT with a control group of current and ex-smokers without emphysema. METHODS: Subjects enrolled had anthropometrics, medical history and a low dose chest computed tomography (LDCT). The following parameters were also evaluated: pulmonary function tests (PFT) including diffusion capacity for carbon monoxide (DLCO), modified MRC dyspnea score, COPD assessment test (CAT) and 6-min walk distance (6MWD)...
November 3, 2016: Chest
https://www.readbyqxmd.com/read/27817926/voc-characteristics-and-inhalation-health-risks-in-newly-renovated-residences-in-shanghai-china
#15
Haixia Dai, Shengao Jing, Hongli Wang, Yingge Ma, Li Li, Weimin Song, Haidong Kan
BACKGROUND: Exposure to indoor VOCs is expected to link to a variety of negative health outcome. The popularity of decorations and refurbishment in homes in China has given rise to indoor elevated VOC levels, potentially posing health threats to residents. METHODS: In this study, concentrations of 101 VOC compounds and associated health risks were investigated in newly renovated homes in Shanghai. The potential excess inhalation health risks from home exposure of 17 health-related VOCs were estimated by the Inhalation Unit Risk (IUR) and Reference Concentration (RfC) proposed by US EPA...
January 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/27811597/predictors-of-at-home-arterial-oxygen-desaturation-events-in-ambulatory-surgical-patients
#16
Chuck Biddle, Charles Elam, Laura Lahaye, Gordon Kerr, Laura Chubb, Brad Verhulst
OBJECTIVES: Little is known about the early recovery phase occurring at-home after anesthesia and surgery in ambulatory surgical patients. We studied quantitative oximetry and quality-of-life metrics in the first 48 hours after same-day orthopedic surgery examining the association between the recovery metrics and specific patient and procedural factors. METHODS: We used the STOP-Bang score to quantify patient risk for obstructive sleep apnea in 50 adult patients at 2 centers using continuous portable oximetry and patient journaling...
November 2, 2016: Journal of Patient Safety
https://www.readbyqxmd.com/read/27799759/is-the-1-minute-sit-to-stand-test-a-good-tool-for-the-evaluation-of-the-impact-of-pulmonary-rehabilitation-determination-of-the-minimal-important-difference-in-copd
#17
Trija Vaidya, Claire de Bisschop, Marc Beaumont, Hakima Ouksel, Véronique Jean, François Dessables, Arnaud Chambellan
BACKGROUND: The 1-minute sit-to-stand (STS) test could be valuable to assess the level of exercise tolerance in chronic obstructive pulmonary disease (COPD). There is a need to provide the minimal important difference (MID) of this test in pulmonary rehabilitation (PR). METHODS: COPD patients undergoing the 1-minute STS test before PR were included. The test was performed at baseline and the end of PR, as well as the 6-minute walk test, and the quadriceps maximum voluntary contraction (QMVC)...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27795840/ex-vivo-expansion-of-hematopoietic-stem-and-progenitor-cells-from-umbilical-cord-blood
#18
E V Sotnezova, E R Andreeva, A I Grigoriev, L B Buravkova
Transplantation of umbilical cord blood cells is currently widely used in modern cell therapy. However, the limited number of hematopoietic stem and progenitor cells (HSPCs) and prolonged time of recovery after the transplantation are significant limitations in the use of cord blood. Ex vivo expansion with various cytokine combinations is one of the most common approaches for increasing the number of HSPCs from one cord blood unit. In addition, there are protocols that enable ex vivo amplification of cord blood cells based on native hematopoietic microenvironmental cues, including stromal components and the tissue-relevant oxygen level...
July 2016: Acta Naturae
https://www.readbyqxmd.com/read/27794080/automatic-oxygen-titration-during-walking-in-subjects-with-copd-a-randomized-crossover-controlled-study
#19
François Lellouche, Erwan L'Her, Pierre-Alexandre Bouchard, Cynthia Brouillard, François Maltais
BACKGROUND: Arterial oxygen desaturation frequently occurs in patients with COPD during daily activities at home. Oxygen flow is usually set at fixed and low rates for ambulatory patients. We evaluated an innovative closed-loop system (FreeO2) that automatically adjusts the oxygen flow to the patient's needs in subjects with COPD during walking followed by recovery time, such as during ambulatory conditions. METHODS: Patients with COPD who exhibited oxygen desaturation on exertion were included in the study...
November 2016: Respiratory Care
https://www.readbyqxmd.com/read/27765939/inadvertent-methylergonovine-administration-to-a-neonate
#20
Bryan M Corbett, Charles O'Connell, Mallory A Boutin, Nabil I Fatayerji, Charles W Sauer
BACKGROUND Methylergonovine is an ergot alkaloid used to treat post-partum hemorrhage secondary to uterine atony. Mistaking methylergonovine for vitamin K with accidental administration to the neonate is a rare iatrogenic illness occurring almost exclusively in the delivery room setting. Complications of ergot alkaloids in neonates include respiratory depression, seizures, and death. CASE REPORT A term infant was inadvertently given 0.1 mg of methylergonovine intramuscularly in the right thigh. The error was only noted when the vial of medication was scanned, after administration, identifying it as methylergonovine rather than vitamin K...
October 21, 2016: American Journal of Case Reports
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