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Skin mole

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https://www.readbyqxmd.com/read/29780576/merkel-cell-carcinoma-extended-lymphadenectomy-and-reconstruction-with-biosynthetic-prosthesis
#1
Enrico Coppola Bottazzi, Adele Noviello, Nicola Moles, Antonio Miro, Augusto Striano, Mario Baiamonte, Francesco Esposito, Francesco Crafa
Introduction: Merkel cell carcinomas (MCC) is an aggressive neuroendocrine carcinoma originating from the Merkel cell in the dermo-epidermal junction. Only 10% of MCC occur on the skin of the trunk. Case report: We report a case of Merkel's abdominal carcinomas treated with extensive inguinal lymphadenectomy and reconstruction of the abdominal wall and inguinal canal using prosthesis GORE® BIO-A® . Discussion: Immunohistochemical analysis by tumor-specific markers is crucial for diagnosis and permits differentiation from other tumors of the skin...
May 2018: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29678380/performance-of-a-computer-aided-digital-dermoscopic-image-analyzer-for-melanoma-detection-in-1-076-pigmented-skin-lesion-biopsies
#2
Francis Del Rosario, Jessica M Farahi, Jesse Drendel, Talayesa Buntinx-Krieg, Joseph Caravaglio, Renee Domozych, Stephanie Chapman, Taylor Braunberger, Robert P Dellavalle, David A Norris, Ramin Fathi, Theodore Alkousakis
BACKGROUND: Digital dermoscopic image analysis of pigmented skin lesions (PSLs) has become increasingly popular, despite its unclear clinical utility. Unbiased, high-powered studies investigating the efficacy of commercially available systems are limited. OBJECTIVE: To investigate the diagnostic performance of the FotoFinder Mole-Analyzer in assessing PSLs for cutaneous melanoma. METHODS: In this 15-year retrospective study, the histopathologies of 1076 biopsied PSLs among a total of 2500 imaged PSLs were collected...
May 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29621833/an-image-processing-and-genetic-algorithm-based-approach-for-the-detection-of-melanoma-in-patients
#3
Christian Salem, Danielle Azar, Sima Tokajian
Melanoma skin cancer is the most aggressive type of skin cancer. It is most commonly caused by excessive exposure to Ultraviolet radiation which triggers uncontrollable proliferation of melanocytes. Early detection makes melanoma relatively easily curable. Diagnosis is usually done using traditional methods such as dermoscopy which consists of a manual examination performed by the physician. However, these methods are not always well founded because they depend heavily on the physician's experience. Hence, there is a great need for a new automated approach in order to make diagnosis more reliable...
February 2018: Methods of Information in Medicine
https://www.readbyqxmd.com/read/29605398/-a-cross-sectional-study-of-the-impact-of-educational-information-on-topical-photoprotection-habits-in-medical-students
#4
P Rodríguez-Zamorano, L Puebla-Tornero, L M Martín-Santos, M L Román-Villaizán, A Guerra-Tapia
OBJECTIVES: Skin cancer (melanoma and non-melanoma) is the most common cancer in humans, with melanoma being the most aggressive. Due to the fact that ultraviolet (UV) radiation exposure is the only adjustable aetiological factor, UV protection is the essential preventive measure. Based on these grounds, a study was conducted in order to compare three population groups with different levels of knowledge about UV protection, as well as to determine any differences in sun exposure habits, and the level of awareness of the damaging effects of the sun on the skin...
March 28, 2018: Semergen
https://www.readbyqxmd.com/read/29593080/resistance-to-dna-damage-and-enhanced-dna-repair-capacity-in-the-hypoxia-tolerant-blind-mole-rat-spalax
#5
Vered Domankevich, Hossam Eddini, Amani Odeh, Imad Shams
The blind mole rat, Spalax , is the only mammalian species, to date, for which spontaneous cancer was never reported and resistance to carcinogens- induced cancers was demonstrated. However, the underlying mechanisms are still poorly understood. The fact that Spalax is also a hypoxia-tolerant and a long-lived species implies for molecular adaptations to prevent genomic instability, which underlies both cancer and aging. We previously demonstrated the up-regulation of transcripts related to DNA replication and repair pathways in Spalax Yet, to date, no direct experimental evidence for improved genomic maintenance was demonstrated for this species...
March 28, 2018: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29580430/hydroxyethyl-methacrylate-grafted-carboxy-methyl-tamarind-cmt-g-hema-polysaccharide-based-matrix-as-a-suitable-scaffold-for-skin-tissue-engineering
#6
Priyanka Choudhury, Satish Kumar, Abhishek Singh, Ashutosh Kumar, Navneet Kaur, Sridhar Sanyasi, Saurabh Chawla, Chandan Goswami, Luna Goswami
Patho-physiologies related to skin are diverse in nature such as burns, skin ulcers, atopic dermatitis, psoriasis etc. which impose severe bio-medical problems and thus enforce requirement of new and healthy skin prepared through tissues engineering methodologies. However, fully functional and biodegradable matrix for attachment, growth, proliferation and differentiation of the relevant cells is not available. In the present study, we introduce a set of hydrogels synthesized by incorporation of a synthetic monomer (Hydroxyethlmethacryate) with a semi-synthetic polymer backbone (carboxy methyl tamarind, CMT) in different mole ratios...
June 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29538697/risk-stratification-for-melanoma-models-derived-and-validated-in-a-purpose-designed-prospective-cohort
#7
Catherine M Olsen, Nirmala Pandeya, Bridie S Thompson, Jean Claude Dusingize, Penelope M Webb, Adele C Green, Rachel E Neale, David C Whiteman
Background: Risk stratification can improve the efficacy and cost-efficiency of screening programs for early detection of cancer. We sought to derive a risk stratification tool for melanoma that was suitable for the general population using only self-reported information. Methods: We used melanoma risk factor information collected at baseline from QSKIN, a prospective cohort study of Queensland adults age 40 to 69 years at recruitment (n = 41 954). We examined two separate outcomes: 1) invasive melanomas and 2) all melanomas (invasive + in situ) obtained through data linkage to the cancer registry...
March 11, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29524457/factors-related-to-nevus-associated-cutaneous-melanoma-a-case-case-study
#8
Nirmala Pandeya, Marina Kvaskoff, Catherine M Olsen, Adèle C Green, Susan Perry, Catherine Baxter, Marcia B Davis, Rohan Mortimore, Lorraine Westacott, Dominic Wood, Joe Triscott, Richard Williamson, David C Whiteman
A proportion of cutaneous melanomas display neval remnants on histologic examination. Converging lines of epidemiologic and molecular evidence suggest that melanomas arising from nevus precursors differ from melanomas arising de novo. In a large, population-based study comprising 636 cutaneous melanomas subjected to dermatopathology review, we explored the molecular, host, and environmental factors associated with the presence of neval remnants. We found that nevus-associated melanomas were significantly associated with younger age at presentation, non-brown eye color, trunk site, thickness of less than 0...
March 7, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29505523/aberrations-and-clinical-significance-of-braf-in-malignant-melanoma-a-series-of-60-cases-in-chinese-uyghur
#9
Xiaojing Kang, Ying Zeng, Junqin Liang, Jing Li, Danyang Ren, Li Chai, Zhenzhu Sun, Shirong Yu, Xiujuan Wu, Wen Han, Weijia Wang
Malignant melanoma (MM) is a highly malignant melanocytic tumor, it occurs mostly in the skin, the mucous membrane close to the skin, but also in the tunicae rhagoides and the pia mater. The Uyghur is the largest ethnic group living in the Xinjiang Uyghur Autonomous Region of China, accounting for 46% of the total population of 20 million. Large-scale studies on MMs in Asian countries are limited. This study aimed to investigate BRAF mRNA expression and mutations in Chinese Uyghur patients with MMs and to identify the clinical features associated with these parameters...
January 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29480992/melanoma-screening-day-in-krasnoyarsk-krai-of-the-russian-federation-results-from-2015-2016
#10
Nadezhda Palkina, Olga Sergeeva, Tatiana Ruksha, Ivan Artyukhov
Objective: The Melanoma Screening Day Campaign started in the Russian Federation in 2006. In the present study, we analyzed the 2015-2016 survey questionnaire data acquired from screened individuals in the city of Krasnoyarsk in eastern Siberia, which has a population of one million, in order to understand the level of awareness regarding melanoma/ skin cancer prevention and early diagnosis. Methods: Individuals were enrolled in the screening campaign by mass media advertising. Free whole-body examinations were provided by the doctors, and the standardized questionnaire forms (n=444) were completed to obtain relevant demographic, epidemiological, and clinical data...
February 26, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29464234/you-should-get-that-mole-checked-out-ethical-and-legal-considerations-of-the-unsolicited-clinical-opinion
#11
Nikki R Adler, Patrick D Mahar, John W Kelly
BACKGROUND: Legal and ethical obligations do not always align when doctors become aware of a clinical situation involving a person with whom they have no pre existing therapeutic relationship. Noting a potentially malignant skin lesion, such as a melanoma on a person outside the clinical setting, provides a pertinent example. OBJECTIVE: The aim of this article is to describe the legal, ethical and professional considerations surrounding proffering a dermatological opinion in the case of suspected melanoma outside the clinical setting...
December 2017: Australian Family Physician
https://www.readbyqxmd.com/read/29432174/naked-mole-rats-can-undergo-developmental-oncogene-induced-and-dna-damage-induced-cellular-senescence
#12
Yang Zhao, Alexander Tyshkovskiy, Daniel Muñoz-Espín, Xiao Tian, Manuel Serrano, Joao Pedro de Magalhaes, Eviatar Nevo, Vadim N Gladyshev, Andrei Seluanov, Vera Gorbunova
Cellular senescence is an important anticancer mechanism that restricts proliferation of damaged or premalignant cells. Cellular senescence also plays an important role in tissue remodeling during development. However, there is a trade-off associated with cellular senescence as senescent cells contribute to aging pathologies. The naked mole rat (NMR) ( Heterocephalus glaber ) is the longest-lived rodent that is resistant to a variety of age-related diseases. Remarkably, NMRs do not show aging phenotypes until very late stages of their lives...
February 20, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29345430/wearable-wireless-tyrosinase-bandage-and-microneedle-sensors-toward-melanoma-screening
#13
Bianca Ciui, Aida Martin, Rupesh K Mishra, Barbara Brunetti, Tatsuo Nakagawa, Thomas J Dawkins, Mengjia Lyu, Cecilia Cristea, Robert Sandulescu, Joseph Wang
Wearable bendable bandage-based sensor and a minimally invasive microneedle biosensor are described toward rapid screening of skin melanoma. These wearable electrochemical sensors are capable of detecting the presence of the tyrosinase (TYR) enzyme cancer biomarker in the presence of its catechol substrate, immobilized on the transducer surface. In the presence of the surface TYR biomarker, the immobilized catechol is rapidly converted to benzoquinone that is detected amperometrically, with a current signal proportional to the TYR level...
January 18, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29314288/the-limitations-of-dermoscopy-false-positive-and-false-negative-tumours
#14
REVIEW
V Papageorgiou, Z Apalla, E Sotiriou, C Papageorgiou, E Lazaridou, S Vakirlis, D Ioannides, A Lallas
Dermoscopy has been documented to increase the diagnostic accuracy of clinicians evaluating skin tumours, improving their ability to detect skin cancer and better recognize benign moles. However, dermoscopically 'false-positive' and 'false-negative' tumours do exist. False-positive diagnosis usually leads to unnecessary excisions. False-negative diagnosis is much more dangerous, as it might result in overlooking a cancer, with severe undesirable consequences for the patient and the physician. Therefore, management strategies should mainly focus on addressing the risk of dermoscopically false-negative tumours...
January 5, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29277542/evolution-of-the-mc5r-gene-in-placental-mammals-with-evidence-for-its-inactivation-in-multiple-lineages-that-lack-sebaceous-glands
#15
Mark S Springer, John Gatesy
MC5R is one of five melanocortin receptor genes found in placental mammals. MC5R plays an important role in energy homeostasis and is also expressed in the terminal differentiation of sebaceous glands. Among placental mammals there are multiple lineages that either lack or have degenerative sebaceous glands including Cetacea (whales, dolphins, and porpoises), Hippopotamidae (hippopotamuses), Sirenia (manatees and dugongs), Proboscidea (elephants), Rhinocerotidae (rhinos), and Heterocephalus glaber (naked mole rat)...
March 2018: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/29234713/promoting-early-detection-of-melanoma-during-the-mammography-experience
#16
A K Rzepecki, N Jain, Y Ali, L Chavez, J Choi, B Schlosser, E Liko-Hazizi, S M Friedewald, J K Robinson
Background: Invasive melanoma, a lethal form of skin cancer, is the seventh most common cancer in women. Factors such as a history of indoor tanning or sunburn and a personal or family history of skin cancer increase a woman's risk of developing a melanoma. Objective: Because the majority of melanomas occur in patients age 40 years or older, which is the age that is recommended for women to begin screening mammograms, the mammogram experience could be used to promote early detection of melanoma by introducing skin self-examinations (SSE) to a population of women who are already invested in preventive health...
December 2017: International Journal of Women's Dermatology
https://www.readbyqxmd.com/read/29191342/cutaneous-sign-of-abuse-kids-are-not-just-little-people
#17
Sphoorthi Jinna, Nina Livingston, Rebecca Moles
Skin injury is the most common form of child physical abuse. Although the pattern and visual appearance of skin injury and the treatment needed for the injury is similar in children and adults, characteristics of infant and childhood skin may complicate the diagnosis of injury. A good understanding of normal developmental presentation of accidental injury from infancy to adulthood, locations for injury that should trigger consideration of abuse, and cutaneous mimics of abuse across the lifespan are critical to the identification of suspected abuse...
November 2017: Clinics in Dermatology
https://www.readbyqxmd.com/read/29133662/a-tiny-tick-can-cause-a-big-health-problem
#18
Manuel John, M Raman, Keith Ryan
Ticks are tiny crawling bugs in the spider family that feed by sucking blood from animals. They are second only to mosquitoes as vectors of human disease, both infectious and toxic. Infected ticks spread over a hundred diseases, some of which are fatal if undetected. They spread the spirochete (which multiplies in the insect's gut) with a subsequent bite to the next host. We describe the only reported cases of peri ocular tick bite from India that presented to us within a span of 3 days and its management. Due suspicion and magnification of the lesions revealed the ticks which otherwise masqueraded as small skin tags/moles on gross examination...
November 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29060843/automatic-diagnosis-of-melanoma-using-linear-and-nonlinear-features-from-digital-image
#19
Tamanna Tabassum Khan Munia, Md Nafiul Alam, Jeremiah Neubert, Reza Fazel-Rezai
Melanoma is the most serious type of skin cancer and causes more deaths than other forms of skin cancer. It is a tiny small malignant mole that is usually black or brown but also appears in other color patterns. Early detection of melanoma is key as this is the time period when it is most likely to be cured. Due to the advancement of smartphone technology, automatic and efficient detection of melanoma mole using a smartphone is an active area of research. In this study, we developed an automatic melanoma diagnosis system using images captured from the digital camera...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29023082/be-vigilant-for-skin-manifestations-of-inherited-cancer-syndromes
#20
Alice SM Tidman
More than 200 hereditary cancer susceptibility syndromes have been described, and it is thought that they account for 5-10% of all cancers. Many have dermatological manifestations (usually lesions, occasionally rashes) which frequently precede other systemic pathology. Dermatological signs are usually non-specific and often trivial in appearance, making their significance easy to overlook and a clinical diagnosis challenging. Histological examination is often required to differentiate lesions. They are usually benign and pathologically unrelated to the primary tumours, with the exception of the atypical moles of the dysplastic naevus syndrome, and may present simply as a cosmetic problem for the patient...
January 2017: Practitioner
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