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https://www.readbyqxmd.com/read/28330494/pseudomonas-oryzihabitans-sepsis-in-a-1-year-old-child-with-multiple-skin-rashes-a-case-report
#1
Michael Owusu, Ellis Owusu-Dabo, Godfred Acheampong, Isaac Osei, John Amuasi, Nimako Sarpong, Augustina Annan, Hsin-Ying Chiang, Chih-Horng Kuo, Se Eun Park, Florian Marks, Yaw Adu-Sarkodie
BACKGROUND: Pseudomonas oryzihabitans is a Pseudomonas bacterial organism rarely implicated in human infections. The bacterium has been isolated in a few reported cases of neurosurgical infections and patients with end-stage cirrhosis, sickle cell disease, and community-acquired urinary tract infections. Limited information exists in developing countries, however, because of the lack of advanced microbiological tools for identification and characterization of this bacterium. This case report describes the isolation of a rare Pseudomonas bacterium in a patient presenting with sepsis and skin infection...
March 23, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28268577/automatic-detection-of-melanoma-using-broad-extraction-of-features-from-digital-images
#2
M H Jafari, S Samavi, N Karimi, S M R Soroushmehr, K Ward, K Najarian
Automatic and reliable diagnosis of skin cancer, as a smartphone application, is of great interest. Among different types of skin cancers, melanoma is the most dangerous one which causes most deaths. Meanwhile, melanoma is curable if it were diagnosed in its early stages. In this paper we propose an efficient system for prescreening of pigmented skin lesions for malignancy using general-purpose digital cameras. These images can be captured by a smartphone or a digital camera. This could be beneficial in different applications, such as computer aided diagnosis and telemedicine applications...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226755/automatic-detection-of-melanoma-using-broad-extraction-of-features-from-digital-images
#3
M H Jafari, S Samavi, N Karimi, S M R Soroushmehr, K Ward, K Najarian, M H Jafari, S Samavi, N Karimi, S M R Soroushmehr, K Ward, K Najarian, K Ward, M H Jafari, S M R Soroushmehr, S Samavi, K Najarian, N Karimi
Automatic and reliable diagnosis of skin cancer, as a smartphone application, is of great interest. Among different types of skin cancers, melanoma is the most dangerous one which causes most deaths. Meanwhile, melanoma is curable if it were diagnosed in its early stages. In this paper we propose an efficient system for prescreening of pigmented skin lesions for malignancy using general-purpose digital cameras. These images can be captured by a smartphone or a digital camera. This could be beneficial in different applications, such as computer aided diagnosis and telemedicine applications...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28195576/the-mole-mapper-study-mobile-phone-skin-imaging-and-melanoma-risk-data-collected-using-researchkit
#4
Dan E Webster, Christine Suver, Megan Doerr, Erin Mounts, Lisa Domenico, Tracy Petrie, Sancy A Leachman, Andrew D Trister, Brian M Bot
Sensor-embedded phones are an emerging facilitator for participant-driven research studies. Skin cancer research is particularly amenable to this approach, as phone cameras enable self-examination and documentation of mole abnormalities that may signal a progression towards melanoma. Aggregation and open sharing of this participant-collected data can be foundational for research and the development of early cancer detection tools. Here we describe data from Mole Mapper, an iPhone-based observational study built using the Apple ResearchKit framework...
February 14, 2017: Scientific Data
https://www.readbyqxmd.com/read/28095445/cytosolic-rna-dna-duplexes-generated-by-endogenous-reverse-transcriptase-activity-as-autonomous-inducers-of-skin-inflammation-in-psoriasis
#5
Jean-Pierre Molès, Anthony Griez, Jean-Jacques Guilhou, Céline Girard, Nicolas Nagot, Philippe Van de Perre, Pierre Dujols
Psoriasis is a chronic skin disease of unknown ætiology. Recent studies suggested that a large amount of cytosolic DNA (cyDNA) in keratinocytes is breaking keratinocytes DNA tolerance and promotes self-sustained inflammation in the psoriatic lesion. We investigated the origin of this cyDNA. We show that, amongst all the possible DNA structures, the cyDNA could be present as RNA:DNA duplexes in keratinocytes. We further show that endogenous reverse transcriptase activities generate such duplexes and consequently activate the production of Th1-inflammatory cytokines...
2017: PloS One
https://www.readbyqxmd.com/read/28095280/relative-importance-of-traditional-risk-factors-for-malignant-melanoma-in-the-czech-population
#6
Lucie Rajská, Dana Göpfertová, Jana Hercogová, Anna Jiráková, Zuzana Sečníková, Filip Rob, Zdeněk Šmerhovský
AIM: The Czech Republic is one of the leading European countries in incident cases of malignant melanoma (MM), which is on the rise. The study objective was to assess the strength of associations between MM and the known generally accepted risk factors for MM in the population of the Czech Republic. METHODS: The study was designed as a case-control study where cases were incident cases of MM detected at the Department of Dermatology and Venereology of the Bulovka Hospital...
December 2016: Central European Journal of Public Health
https://www.readbyqxmd.com/read/27964893/dermatological-cancer-screening-evaluation-of-a-new-community-pharmacy-service
#7
Reidun L S Kjome, David J Wright, Anne-Kristin B Bjaaen, Kjersti W Garstad, Mette Valeur
BACKGROUND: Skin cancer accounts for one third of all cancers. Prognosis is inversely related to identification stage. OBJECTIVES: To describe a novel service, mole scans, performed in community pharmacy, the findings from the first 3.5 years it was in place, and to explore patient acceptability of the service. METHODS: Norwegian Boots' pharmacies offer a mole scanning service in cooperation with ScreenCancer. Scans are undertaken within pharmacy consultation rooms...
December 6, 2016: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/27926637/pigmentation-and-pregnancy-knowing-what-is-normal
#8
Amy Kalowitz Bieber, Kathryn J Martires, Jennifer A Stein, Jane M Grant-Kels, Marcia S Driscoll, Miriam Keltz Pomeranz
Changes in melanocytic nevi during pregnancy are frequently attributed to the new hormonal milieu and are dismissed without concern for malignancy. Recent studies suggest that pregnancy itself does not induce significant change in nevi, and delays in the assessment of changing moles may contribute to the often more advanced nature of melanomas diagnosed during or soon after pregnancy. Nevi on the breasts and abdomen can grow as a result of skin expansion, but studies have found no significant changes in nevi located in more stable areas such as the back or lower extremities...
January 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27886809/small-mammal-utilization-by-middle-stone-age-humans-at-die-kelders-cave-1-and-pinnacle-point-site-5-6-western-cape-province-south-africa
#9
Aaron Armstrong
Reported here are the results of a taphonomic analysis of the small mammals (between 0.75 kg and 4.5 kg adult body weight) and size 1 bovids (≤20 kg adult body weight) from the Middle Stone Age (MSA) sites of Die Kelders Cave 1 (DK1) and Pinnacle Point Site 5-6 (PP5-6), Western Cape Province, South Africa. This study provides a comprehensive taphonomic analysis of MSA small mammals with a focus on discerning the role of humans in their accumulation and the implications for human behavioral adaptations...
December 2016: Journal of Human Evolution
https://www.readbyqxmd.com/read/27863375/h2o2-treatment-or-serum-deprivation-induces-autophagy-and-apoptosis-in-naked-mole-rat-skin-fibroblasts-by-inhibiting-the-pi3k-akt-signaling-pathway
#10
Shanmin Zhao, Li Li, Shiyong Wang, Chenlin Yu, Bang Xiao, Lifang Lin, Wei Cong, Jishuai Cheng, Wenjing Yang, Wei Sun, Shufang Cui
Naked mole-rats (NMR; Heterocephalus glaber) display extreme longevity and resistance to cancer. Here, we examined whether autophagy contributes to the longevity of NMRs by assessing the effects of the PI3K/Akt pathway inhibitor LY294002 and the autophagy inhibitor chloroquine (CQ) on autophagy and apoptosis in NMR skin fibroblasts. Serum starvation, H2O2 treatment, and LY294002 treatment all increased the LC3-II/LC3-I ratio and numbers of double-membraned autophagosomes and autophagic vacuoles, and decreased levels of p70S6K, p-AktSer473, and p-AktThr308...
November 12, 2016: Oncotarget
https://www.readbyqxmd.com/read/27768578/a-prospective-observational-study-to-assess-the-use-of-thermography-to-predict-progression-of-discolored-intact-skin-to-necrosis-among-patients-in-skilled-nursing-facilities
#11
Jill Cox, Loretta Kaes, Miguel Martinez, Daniel Moles
Skin temperature may help prospectively determine whether an area of skin discoloration will evolve into necrosis. A prospective, observational study was conducted in 7 skilled nursing facilities to determine if skin temperature measured using infrared thermography could predict the progression of discolored intact skin (blanchable erythema, Stage 1 pressure ulcer, or sus- pected deep tissue injury [sDTI]) to necrosis and to evaluate if nurses could effectively integrate thermography into the clinical setting...
October 2016: Ostomy/wound Management
https://www.readbyqxmd.com/read/27757237/coping-with-heat-behavioural-and-physiological-responses-of-savanna-elephants-in-their-natural-habitat
#12
Michael A Mole, Shaun Rodrigues DÁraujo, Rudi J van Aarde, Duncan Mitchell, Andrea Fuller
Most of southern Africa's elephants inhabit environments where environmental temperatures exceed body temperature, but we do not know how elephants respond to such environments. We evaluated the relationships between apparent thermoregulatory behaviour and environmental, skin and core temperatures for tame savanna elephants (Loxodonta africana) that were free-ranging in the hot parts of the day, in their natural environment. Environmental temperature dictated elephant behaviour within a day, with potential consequences for fine-scale habitat selection, space use and foraging...
2016: Conservation Physiology
https://www.readbyqxmd.com/read/27748606/ph-sensitive-nanomicelles-for-high-efficiency-sirna-delivery-in-vitro-and-in-vivo-an-insight-into-the-design-of-polycations-with-robust-cytosolic-release
#13
Junhui Zhou, Yidi Wu, Changrong Wang, Qiang Cheng, Shangcong Han, Xiaoxia Wang, Jianhua Zhang, Liandong Deng, Deyao Zhao, Lili Du, Huiqing Cao, Zicai Liang, Yuanyu Huang, Anjie Dong
The extremely low efficient cytosolic release of the internalized siRNA has emerged recently as a central issue for siRNA delivery, while there is a lack of guidelines to facilitate the cytosolic release of internalized siRNA. To address these concerns, we studied the contribution of the pH-sensitive inner core on handling the cytosolic release of siRNA delivered by a series of PG-P(DPAx-co-DMAEMAy)-PCB amphiphilic polycation nanomicelles (GDDC-Ms) with extremely low internalization (<1/4 of lipofactamine 2000 (Lipo2000))...
November 9, 2016: Nano Letters
https://www.readbyqxmd.com/read/27689254/doctors-recognition-and-management-of-melanoma-patients-risk-an-australian-population-based-study
#14
C M Madronio, B K Armstrong, C G Watts, C Goumas, R L Morton, A Curtin, S W Menzies, G J Mann, J F Thompson, A E Cust
BACKGROUND: Guidelines recommend that health professionals identify and manage individuals at high risk of developing melanoma, but there is limited population-based evidence demonstrating real-world practices. OBJECTIVE: A population-based, observational study was conducted in the state of New South Wales, Australia to determine doctors' knowledge of melanoma patients' risk and to identify factors associated with better identification and clinical management. METHODS: Data were analysed for 1889 patients with invasive, localised melanoma in the Melanoma Patterns of Care study...
December 2016: Cancer Epidemiology
https://www.readbyqxmd.com/read/27676207/immunohistochemical-localization-of-androgen-receptors-in-female-mole-rat-spalax-leucodon-tissues
#15
F M Gur, S Timurkaan
Androgens exert their effects through androgen receptors (AR) in tissues. We investigated the distribution of AR in female mole rat tissues. Tissues were excised, fixed with 10% formalin and embedded in paraffin. Sections were stained after microwave antigen retrieval for immunohistochemistry. Immunostaining of AR immunostaining was detected in the nucleus or cytoplasm of the cells in the cerebral cortex, cerebellum, anterior pituitary, lung, liver, uterus and skin. Granulosa and some thecal cells in the ovary, cardiac muscle cells and adipose cells exhibited a nuclear reaction for AR...
October 2016: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
https://www.readbyqxmd.com/read/27646736/nevi-and-pregnancy
#16
REVIEW
Amy Kalowitz Bieber, Kathryn J Martires, Marcia S Driscoll, Jane M Grant-Kels, Miriam Keltz Pomeranz, Jennifer A Stein
Changes in the moles of pregnant women are frequently attributed to pregnancy, but recent studies suggest that pregnancy does not induce significant physiologic changes in nevi. It is common for nevi on the breasts and abdomen to grow with normal skin expansion, but studies that have examined melanocytic nevi on the backs or lower extremities have found no significant changes in size during pregnancy. Several studies have also investigated the belief that moles darken during pregnancy and have found insufficient evidence to support this idea...
October 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27606221/does-hearing-about-cancer-influence-stimulus-control-an-exploratory-study-of-verbal-modulation-of-stimulus-generalization
#17
Thomas S Critchfield, Derek D Reed
Participants first became familiar with an image showing moderate symptoms of the skin cancer melanoma. In a generalization test, they indicated whether images showing more and less pronounced symptoms were "like the original." Some groups (cancer context) were told that the images depicted melanoma and that the disease is deadly unless detected early. Control groups were not told what the images depicted. For control groups, generalization gradients were fairly typical of what is normally reported in the generalization literature, but for cancer context groups, gradients were shifted such that highly symptomatic moles were identified as "like the original" more than normal and subtly symptomatic ones were endorsed less than normal...
June 2016: Analysis of Verbal Behavior
https://www.readbyqxmd.com/read/27517357/melanocytic-nevi-in-children-a-review
#18
REVIEW
Rebecca Levy, Irene Lara-Corrales
Common moles on the skin, known scientifically as melanocytic nevi, are seen frequently in the pediatric population. They are broadly grouped into two groups: congenital (generally present at birth or in infancy) or acquired. Congenital melanocytic nevi (CMN) are classified based on size and morphologic features. Neurocutaneous melanosis and melanoma represent two important complications, with overall risk affected by nevus size, location, appearance, and number of satellite lesions. Regular lifelong skin surveillance is required for high-risk CMN...
August 1, 2016: Pediatric Annals
https://www.readbyqxmd.com/read/27382567/computer-aided-diagnosis-of-micro-malignant-melanoma-lesions-applying-support-vector-machines
#19
Joanna Jaworek-Korjakowska
Background. One of the fatal disorders causing death is malignant melanoma, the deadliest form of skin cancer. The aim of the modern dermatology is the early detection of skin cancer, which usually results in reducing the mortality rate and less extensive treatment. This paper presents a study on classification of melanoma in the early stage of development using SVMs as a useful technique for data classification. Method. In this paper an automatic algorithm for the classification of melanomas in their early stage, with a diameter under 5 mm, has been presented...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27337542/visual-exemplification-and-skin-cancer-the-utility-of-exemplars-in-promoting-skin-self-exams-and-atypical-nevi-identification
#20
Andy J King
The present article reports an experiment investigating untested propositions of exemplification theory in the context of messages promoting early melanoma detection. The study tested visual exemplar presentation types, incorporating visual persuasion principles into the study of exemplification theory and strategic message design. Compared to a control condition, representative visual exemplification was more effective at increasing message effectiveness by eliciting a surprise response, which is consistent with predictions of exemplification theory...
July 2016: Journal of Health Communication
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