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https://www.readbyqxmd.com/read/29133662/a-tiny-tick-can-cause-a-big-health-problem
#1
Manuel John, M Raman, Keith Ryan
Ticks are tiny crawling bugs in the spider family that feed by sucking blood from animals. They are second only to mosquitoes as vectors of human disease, both infectious and toxic. Infected ticks spread over a hundred diseases, some of which are fatal if undetected. They spread the spirochete (which multiplies in the insect's gut) with a subsequent bite to the next host. We describe the only reported cases of peri ocular tick bite from India that presented to us within a span of 3 days and its management. Due suspicion and magnification of the lesions revealed the ticks which otherwise masqueraded as small skin tags/moles on gross examination...
November 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29060843/automatic-diagnosis-of-melanoma-using-linear-and-nonlinear-features-from-digital-image
#2
Tamanna Tabassum Khan Munia, Md Nafiul Alam, Jeremiah Neubert, Reza Fazel-Rezai
Melanoma is the most serious type of skin cancer and causes more deaths than other forms of skin cancer. It is a tiny small malignant mole that is usually black or brown but also appears in other color patterns. Early detection of melanoma is key as this is the time period when it is most likely to be cured. Due to the advancement of smartphone technology, automatic and efficient detection of melanoma mole using a smartphone is an active area of research. In this study, we developed an automatic melanoma diagnosis system using images captured from the digital camera...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29023082/be-vigilant-for-skin-manifestations-of-inherited-cancer-syndromes
#3
Alice SM Tidman
More than 200 hereditary cancer susceptibility syndromes have been described, and it is thought that they account for 5-10% of all cancers. Many have dermatological manifestations (usually lesions, occasionally rashes) which frequently precede other systemic pathology. Dermatological signs are usually non-specific and often trivial in appearance, making their significance easy to overlook and a clinical diagnosis challenging. Histological examination is often required to differentiate lesions. They are usually benign and pathologically unrelated to the primary tumours, with the exception of the atypical moles of the dysplastic naevus syndrome, and may present simply as a cosmetic problem for the patient...
January 2017: Practitioner
https://www.readbyqxmd.com/read/28942299/pathological-findings-in-wild-rats-rattus-rattus-captured-at-guafo-island-northern-chilean-patagonia
#4
M Seguel, F Muñoz, E Paredes, M J Navarrete, N L Gottdenker
The black rat (Rattus rattus) is an invasive species and potential reservoir of significant pathogens of man, domestic animals and wildlife. During the 2012-2014 austral summers, 201 black rats were captured and examined on the uninhabited Guafo Island, in Northern Chilean Patagonia (43.593029°S, 74.713481°W). The mite Ornithonyssus bacoti caused lymphoplasmacytic and eosinophilic dermatitis in all infected rats (105/210, 52%), but no skin lesions were observed in rats infected with Nosopsyllus spp. and Plocopsylla spp...
August 2017: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/28886799/mole-mapping-for-management-of-pigmented-skin-lesions
#5
REVIEW
Juliana Berk-Krauss, David Polsky, Jennifer A Stein
Identifying new or changing melanocytic lesions, particularly in patients with numerous or atypical nevi, can be challenging. Total-body photography and sequential digital dermoscopy imaging, together known as digital follow-up, are 2 prominent forms of noninvasive imaging technology used in mole mapping that have been found to improve diagnostic accuracy, detect earlier-stage melanomas, and reduce costs. Digital follow-up, in combination with direct-to-consumer applications and teledermatology, is already revolutionizing the ways in which physicians and patients participate in melanoma surveillance and will likely continue to enhance early detection efforts...
October 2017: Dermatologic Clinics
https://www.readbyqxmd.com/read/28813744/alkaptonuria-a-case-report-with-diagnostic-challenge
#6
Vasantha L Gali, Amy M Kerkvliet, Jacob M Kusmak, Jana K Elwood
Alkaptonuria is a rare autosomal recessive metabolic disorder caused by deficiency of homogentisic acid (HGA) oxidase, the only enzyme capable of catabolizing HGA. Deficiency of this enzyme leads to excess HGA which deposits in the connective tissue. We present a case of a 64-year-old woman who was referred to the dermatology clinic for a full body mole check and skin cancer screening. Clinically she had blue/gray pigmentation of the external ear and sclera. Also she had a domed papule on the left cheek with punctate gray pigmentation which was biopsied...
August 2017: South Dakota Medicine: the Journal of the South Dakota State Medical Association
https://www.readbyqxmd.com/read/28759333/do-pattern-focused-visuals-improve-skin-self-examination-performance-explicating-the-visual-skill-acquisition-model
#7
RANDOMIZED CONTROLLED TRIAL
Kevin K John, Jakob D Jensen, Andy J King, Chelsea L Ratcliff, Douglas Grossman
Skin self-examination (SSE) consists of routinely checking the body for atypical moles that might be cancerous. Identifying atypical moles is a visual task; thus, SSE training materials utilize pattern-focused visuals to cultivate this skill. Despite widespread use, researchers have yet to explicate how pattern-focused visuals cultivate visual skill. Using eye tracking to capture the visual scanpaths of a sample of laypersons (N = 92), the current study employed a 2 (pattern: ABCDE vs. ugly duckling sign [UDS]) × 2 (presentation: photorealistic images vs...
September 2017: Journal of Health Communication
https://www.readbyqxmd.com/read/28672778/correction-h2o2-treatment-or-serum-deprivation-induces-autophagy-and-apoptosis-in-naked-mole-rat-skin-fibroblasts-by-inhibiting-the-pi3k-akt-signaling-pathway
#8
Shanmin Zhao, Li Li, Shiyong Wang, Chenlin Yu, Bang Xiao, Lifang Lin, Wei Cong, Jishuai Cheng, Wenjing Yang, Wei Sun, Shufang Cui
No abstract text is available yet for this article.
June 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28662900/revisiting-the-use-of-spla2-sensitive-liposomes-in-cancer-therapy
#9
Houman Pourhassan, Gael Clergeaud, Anders E Hansen, Ragnhild G Østrem, Frederikke P Fliedner, Fredrik Melander, Ole L Nielsen, Ciara K O'Sullivan, Andreas Kjær, Thomas L Andresen
The first developed secretory phospholipase A2 (sPLA2) sensitive liposomal cisplatin formulation (LiPlaCis®) is currently undergoing clinical evaluation. In the present study we revisit and evaluate critical preclinical parameters important for the therapeutic potential and safety of platinum drugs, here oxaliplatin (L-OHP), formulated in sPLA2 sensitive liposomes. We show the mole percentage of negatively charged phospholipid needed to obtain enzyme-sensitivity for saturated systems is ≥25% for 16-carbon chain lipid membranes, and >40% for 18-chain lipid membranes, which was surprising as 25% is used clinically in LiPlaCis®...
September 10, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28593303/factors-in-early-adolescence-associated-with-a-mole-prone-phenotype-in-late-adolescence
#10
Haoming Xu, Michael A Marchetti, Stephen W Dusza, Esther Chung, Maira Fonseca, Alon Scope, Alan C Geller, Marilyn Bishop, Ashfaq A Marghoob, Allan C Halpern
Importance: Nevi are important phenotypic risk factors for melanoma in adults. Few studies have examined the constitutional and behavioral factors associated with a mole-prone phenotype in adolescents. Objective: To identify host, behavioral, and dermoscopic factors in early adolescence (age, 14 years) that are associated with a mole-prone phenotype in late adolescence (age, 17 years). Design, Setting, and Participants: A prospective observational cohort study from the Study of Nevi in Children was conducted from January 1, 2009, to December 31, 2014, with a 2- to 3-year follow-up...
October 1, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28512610/melanoma-is-skin-deep-a-3d-reconstruction-technique-for-computerized-dermoscopic-skin-lesion-classification
#11
T Y Satheesha, D Satyanarayana, M N Giri Prasad, Kashyap D Dhruve
Melanoma mortality rates are the highest amongst skin cancer patients. Melanoma is life threating when it grows beyond the dermis of the skin. Hence, depth is an important factor to diagnose melanoma. This paper introduces a non-invasive computerized dermoscopy system that considers the estimated depth of skin lesions for diagnosis. A 3-D skin lesion reconstruction technique using the estimated depth obtained from regular dermoscopic images is presented. On basis of the 3-D reconstruction, depth and 3-D shape features are extracted...
2017: IEEE Journal of Translational Engineering in Health and Medicine
https://www.readbyqxmd.com/read/28360969/ticks-and-tick-bites-presenting-as-funny-moles-a-review-of-different-presentations-and-a-focus-on-tick-borne-diseases
#12
Joseph R Kallini, Amor Khachemoune
Purpose: To describe a man with an adherent tick mimicking a melanoma, summarize the salient features of this condition, and review other cases of ticks mistaken for dermatoses. Background: Ticks are obligatory ectoparasites. Disease-causing ticks belong to two families: Ixodidae (hard ticks) and Argasidae (soft ticks). Ticks thrive by consuming blood from animal hosts, and the transfer of infected blood from one host to the next is the method by which ticks spread disease. Materials and methods: The authors describe a man who presented to their dermatology clinic in New York with an unusual black pigmented lesion on the right zygomatic region of his face...
March 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/28342106/extraction-of-skin-lesions-from-non-dermoscopic-images-for-surgical-excision-of-melanoma
#13
M Hossein Jafari, Ebrahim Nasr-Esfahani, Nader Karimi, S M Reza Soroushmehr, Shadrokh Samavi, Kayvan Najarian
PURPOSE: Computerized prescreening of suspicious moles and lesions for malignancy is of great importance for assessing the need and the priority of the removal surgery. Detection can be done by images captured by standard cameras, which are more preferable due to low cost and availability. One important step in computerized evaluation is accurate detection of lesion's region, i.e., segmentation of an image into two regions as lesion and normal skin. METHODS: In this paper, a new method based on deep neural networks is proposed for accurate extraction of a lesion region...
June 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28330494/pseudomonas-oryzihabitans-sepsis-in-a-1-year-old-child-with-multiple-skin-rashes-a-case-report
#14
Michael Owusu, Ellis Owusu-Dabo, Godfred Acheampong, Isaac Osei, John Amuasi, Nimako Sarpong, Augustina Annan, Hsin-Ying Chiang, Chih-Horng Kuo, Se Eun Park, Florian Marks, Yaw Adu-Sarkodie
BACKGROUND: Pseudomonas oryzihabitans is a Pseudomonas bacterial organism rarely implicated in human infections. The bacterium has been isolated in a few reported cases of neurosurgical infections and patients with end-stage cirrhosis, sickle cell disease, and community-acquired urinary tract infections. Limited information exists in developing countries, however, because of the lack of advanced microbiological tools for identification and characterization of this bacterium. This case report describes the isolation of a rare Pseudomonas bacterium in a patient presenting with sepsis and skin infection...
March 23, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28268577/automatic-detection-of-melanoma-using-broad-extraction-of-features-from-digital-images
#15
M H Jafari, S Samavi, N Karimi, S M R Soroushmehr, K Ward, K Najarian
Automatic and reliable diagnosis of skin cancer, as a smartphone application, is of great interest. Among different types of skin cancers, melanoma is the most dangerous one which causes most deaths. Meanwhile, melanoma is curable if it were diagnosed in its early stages. In this paper we propose an efficient system for prescreening of pigmented skin lesions for malignancy using general-purpose digital cameras. These images can be captured by a smartphone or a digital camera. This could be beneficial in different applications, such as computer aided diagnosis and telemedicine applications...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226755/automatic-detection-of-melanoma-using-broad-extraction-of-features-from-digital-images
#16
M H Jafari, S Samavi, N Karimi, S M R Soroushmehr, K Ward, K Najarian, M H Jafari, S Samavi, N Karimi, S M R Soroushmehr, K Ward, K Najarian, K Ward, M H Jafari, S M R Soroushmehr, S Samavi, K Najarian, N Karimi
Automatic and reliable diagnosis of skin cancer, as a smartphone application, is of great interest. Among different types of skin cancers, melanoma is the most dangerous one which causes most deaths. Meanwhile, melanoma is curable if it were diagnosed in its early stages. In this paper we propose an efficient system for prescreening of pigmented skin lesions for malignancy using general-purpose digital cameras. These images can be captured by a smartphone or a digital camera. This could be beneficial in different applications, such as computer aided diagnosis and telemedicine applications...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28195576/the-mole-mapper-study-mobile-phone-skin-imaging-and-melanoma-risk-data-collected-using-researchkit
#17
Dan E Webster, Christine Suver, Megan Doerr, Erin Mounts, Lisa Domenico, Tracy Petrie, Sancy A Leachman, Andrew D Trister, Brian M Bot
Sensor-embedded phones are an emerging facilitator for participant-driven research studies. Skin cancer research is particularly amenable to this approach, as phone cameras enable self-examination and documentation of mole abnormalities that may signal a progression towards melanoma. Aggregation and open sharing of this participant-collected data can be foundational for research and the development of early cancer detection tools. Here we describe data from Mole Mapper, an iPhone-based observational study built using the Apple ResearchKit framework...
February 14, 2017: Scientific Data
https://www.readbyqxmd.com/read/28095445/cytosolic-rna-dna-duplexes-generated-by-endogenous-reverse-transcriptase-activity-as-autonomous-inducers-of-skin-inflammation-in-psoriasis
#18
COMPARATIVE STUDY
Jean-Pierre Molès, Anthony Griez, Jean-Jacques Guilhou, Céline Girard, Nicolas Nagot, Philippe Van de Perre, Pierre Dujols
Psoriasis is a chronic skin disease of unknown ætiology. Recent studies suggested that a large amount of cytosolic DNA (cyDNA) in keratinocytes is breaking keratinocytes DNA tolerance and promotes self-sustained inflammation in the psoriatic lesion. We investigated the origin of this cyDNA. We show that, amongst all the possible DNA structures, the cyDNA could be present as RNA:DNA duplexes in keratinocytes. We further show that endogenous reverse transcriptase activities generate such duplexes and consequently activate the production of Th1-inflammatory cytokines...
2017: PloS One
https://www.readbyqxmd.com/read/28095280/relative-importance-of-traditional-risk-factors-for-malignant-melanoma-in-the-czech-population
#19
Lucie Rajská, Dana Göpfertová, Jana Hercogová, Anna Jiráková, Zuzana Sečníková, Filip Rob, Zdeněk Šmerhovský
AIM: The Czech Republic is one of the leading European countries in incident cases of malignant melanoma (MM), which is on the rise. The study objective was to assess the strength of associations between MM and the known generally accepted risk factors for MM in the population of the Czech Republic. METHODS: The study was designed as a case-control study where cases were incident cases of MM detected at the Department of Dermatology and Venereology of the Bulovka Hospital...
December 2016: Central European Journal of Public Health
https://www.readbyqxmd.com/read/27964893/dermatological-cancer-screening-evaluation-of-a-new-community-pharmacy-service
#20
Reidun L S Kjome, David J Wright, Anne-Kristin B Bjaaen, Kjersti W Garstad, Mette Valeur
BACKGROUND: Skin cancer accounts for one third of all cancers. Prognosis is inversely related to identification stage. OBJECTIVES: To describe a novel service, mole scans, performed in community pharmacy, the findings from the first 3.5 years it was in place, and to explore patient acceptability of the service. METHODS: Norwegian Boots' pharmacies offer a mole scanning service in cooperation with ScreenCancer. Scans are undertaken within pharmacy consultation rooms...
November 2017: Research in Social & Administrative Pharmacy: RSAP
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