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https://www.readbyqxmd.com/read/28215010/key-actions-towards-the-sustainable-management-of-european-geese
#1
David A Stroud, Jesper Madsen, Anthony D Fox
Increasing abundance of geese in North America and Europe constitutes a major conservation success, but has caused increasing conflicts with economic, health and safety interests, as well as ecosystem impacts. Potential conflict resolution through a single, 'one size fits all' policy is hindered by differences in species' ecology, behaviour, abundance and population status, and in contrasting political and socio-economic environments across the flyways. Effective goose management requires coordinated application of a suite of tools from the local level to strategic flyway management actions...
March 2017: Ambio
https://www.readbyqxmd.com/read/28214988/an-alternative-splice-variant-of-human-%C3%AE-a-crystallin-modulates-the-oligomer-ensemble-and-the-chaperone-activity-of-%C3%AE-crystallins
#2
Waldemar Preis, Annika Bestehorn, Johannes Buchner, Martin Haslbeck
In humans, ten genes encode small heat shock proteins with lens αA-crystallin and αB-crystallin representing two of the most prominent members. The canonical isoforms of αA-crystallin and αB-crystallin collaborate in the eye lens to prevent irreversible protein aggregation and preserve visual acuity. α-Crystallins form large polydisperse homo-oligomers and hetero-oligomers and as part of the proteostasis system bind substrate proteins in non-native conformations, thereby stabilizing them. Here, we analyzed a previously uncharacterized, alternative splice variant (isoform 2) of human αA-crystallin with an exchanged N-terminal sequence...
February 18, 2017: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/28214945/characterization-of-tunneling-nanotubes-in-wharton-s-jelly-mesenchymal-stem-cells-an-intercellular-exchange-of-components-between-neighboring-cells
#3
Viviana Sanchez, Nerina Villalba, Luciano Fiore, Carlos Luzzani, Santiago Miriuka, Alberto Boveris, Ricardo J Gelpi, Alicia Brusco, Juan José Poderoso
Intercellular communication is one of the most important events in cell population behavior. In the last decade, tunneling nanotubes (TNTs) have been recognized as a new form of long distance intercellular connection. TNT function is to allow molecular and subcellular structure exchange between neighboring cells via the transfer of molecules and organelles such as calcium ions, prions, viral and bacterial pathogens, small lysosomes and mitochondria. New findings support the concept that mesenchymal stem cells (MSCs) can affect cell microenvironment by the release of soluble factors or the transfer of cellular components to neighboring cells, in a way which significantly contributes to cell regulation and tissue repair, although the underlying mechanisms remain poorly understood...
February 18, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/28214936/an-assessment-of-strontium-sorption-onto-bentonite-buffer-material-in-waste-repository
#4
Pankaj Pathak
In the present study, changes occurring in sorption characteristics of a representative bentonite (WIn-BT) exposed to SrCl2 (0.001-0.1 M) under the pH range of 1-13 were investigated. Such interaction revealed a significant variation in surface charge density and binding energy of ions with respect to bentonite, and alteration in their physicochemical properties viz., specific surface area, cation exchange capacity, thermal and mechanical behaviour were observed. The distribution coefficients (k d) calculated for sorption onto virgin (UCBT) and contaminated bentonite (CBT) indicated a greater influence of mineralogical changes occurred with variance of pH and strontium concentration...
February 18, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28214935/promotive-role-of-5-aminolevulinic-acid-on-chromium-induced-morphological-photosynthetic-and-oxidative-changes-in-cauliflower-brassica-oleracea-botrytis-l
#5
Rehan Ahmad, Shafaqat Ali, Fakhir Hannan, Muhammad Rizwan, Muhammad Iqbal, Zaidul Hassan, Nudrat Aisha Akram, Saliha Maqbool, Farhat Abbas
Chromium (Cr) is among the most toxic pollutants in the environment that adversely affect the living organisms and physiological processes in different plants. The present study investigated the effect of 15 mg L(-1) of 5-aminolevulinic acid (ALA) on morpho-physiological attributes of cauliflower (Brassica oleracea botrytis L.) under different Cr concentrations (0, 10, 100, and 200 μM) in the growth medium. The results showed that Cr stress decreased the growth, biomass, photosynthetic, and gas exchange parameters...
February 18, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28214919/grapevine-acclimation-to-water-deficit-the-adjustment-of-stomatal-and-hydraulic-conductance-differs-from-petiole-embolism-vulnerability
#6
Uri Hochberg, Andrea Giulia Bonel, Rakefet David-Schwartz, Asfaw Degu, Aaron Fait, Hervé Cochard, Enrico Peterlunger, Jose Carlos Herrera
Drought-acclimated vines maintained higher gas exchange compared to irrigated controls under water deficit; this effect is associated with modified leaf turgor but not with improved petiole vulnerability to cavitation. A key feature for the prosperity of plants under changing environments is the plasticity of their hydraulic system. In the present research we studied the hydraulic regulation in grapevines (Vitis vinifera L.) that were first acclimated for 39 days to well-watered (WW), sustained water deficit (SD), or transient-cycles of dehydration-rehydration-water deficit (TD) conditions, and then subjected to varying degrees of drought...
February 18, 2017: Planta
https://www.readbyqxmd.com/read/28214789/-truth-in-research-labelling-regarding-wame-s-quoted-comments
#7
Margaret Winker
We were surprised to read Dr Noble's article, "Truth in research labelling". Dr Noble quotes from an email exchange he and I had regarding a petition that he had asked the World Association of Medical Editors (WAME) to endorse (personal communication, Bernard Carroll and John Noble, September 27, 2016). Unfortunately, the article's description of WAME's comments, which were intended to provide constructive suggestions to improve the petition by ensuring that it was fully supported by facts, is incomplete and the comments have been taken out of context...
February 13, 2017: Indian Journal of Medical Ethics
https://www.readbyqxmd.com/read/28214778/thiol-disulfide-homeostasis-in-untreated-schizophrenia-patients
#8
Canan Topcuoglu, Abdurrahim Bakirhan, Fatma Meric Yilmaz, Salim Neselioglu, Ozcan Erel, Safak Yalcin Sahiner
BACKROUND: The aim of the study was to investigate dynamic thiol/disulfide (SH/SS) homeostasis in untreated schizophrenia. METHODS: Blood thiol/disulfide homeostasis status, which reflects native thiol-disulfide exchanges, was investigated in 87 untreated patients (52 males, 35 females), and the obtained results were compared with 86 healthy controls. Blood serum native thiol and total thiol (ToSH) concentrations were measured in a paired test. The half value of the difference between native thiol and ToSH concentrations was calculated as the disulfide bond amount...
February 7, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28214669/correlates-of-overweight-and-obesity-in-5529-adolescents-with-type-1-diabetes-the-t1d-exchange-clinic-registry
#9
Karl E Minges, Robin Whittemore, Stuart A Weinzimer, Melinda L Irwin, Nancy S Redeker, Margaret Grey
AIMS: To describe the prevalence of overweight and obesity in adolescents with type 1 diabetes (T1D) and to examine the associations among socio-demographic, clinical, and self-management factors by weight status. METHODS: We analyzed baseline data obtained from 5529 adolescents with T1D (mean age=15.4±1.4years, 51.8% male, 77.9% white, mean HbA1c=8.7±1.8%; 72mmol/mol) from the T1D Exchange Clinic Registry. We examined correlates of weight status using multinomial logistic regression analyses...
February 4, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28214604/the-measurement-of-dlno-and-dlco-a-manufacturer-s-perspective
#10
X Giraud, N N Le-Dong, K Hogben, J B Martinot
The simultaneous measurement of the lung transfer factor for carbon monoxide (DLCO) and nitric oxide (DLNO) is now available as a powerful method for studying the alveolar-capillary gas exchange. However, application of the DLNO-CO technique in daily settings is still limited by some technical drawbacks. This paper provides a manufacturer's overview of the measuring principles, technical challenges and current available solutions for implementing the DLNO-CO measurement in to a marketed device. This includes the recent developments in technology for NO sensors, latest findings on NO uptake and new statistical methods...
February 15, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28214562/leveraging-health-informatics-to-a-foster-smart-systems-response-to-health-disparities-and-health-equity-challenges
#11
Timothy Jay Carney, Amanda Y Kong
Informaticians are challenged to design health IT solutions for complex problems like health disparities but are only achieving mixed results in demonstrating a direct impact on health outcomes. This presentation of collective intelligence and the corresponding terms of smart health, knowledge ecosystem, enhanced health disparities informatics capacities, knowledge exchange, big-data, and situational awareness are means of demonstrating the complex challenges informatics professional face in trying to model, measure, and manage an intelligence and a smart systems response to health disparities...
February 15, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28214347/involvement-of-the-guanine-nucleotide-exchange-factor-vav3-in-central-nervous-system-development-and-plasticity
#12
Annika Ulc, Christine Gottschling, Ina Schäfer, David Wegrzyn, Simon van Leeuwen, Veronika Luft, Jacqueline Reinhard, Andreas Faissner
Small GTP-hydrolysing enzymes (GTPases) of the RhoA family play manifold roles in cell biology and are regulated by upstream guanine nucleotide exchange factors (GEFs). Herein, we focus on the GEFs of the Vav subfamily. Vav1 was originally described as a protooncogene of the hematopoietic lineage. The GEFs Vav2 and Vav3 are more broadly expressed in various tissues. In particular, the GEF Vav3 may play important roles in the developing nervous system during the differentiation of neural stem cells into the major lineages, namely neurons, oligodendrocytes and astrocytes...
February 18, 2017: Biological Chemistry
https://www.readbyqxmd.com/read/28214167/psychometric-evaluation-and-design-of-patient-centered-communication-measures-for-cancer-care-settings
#13
Bryce B Reeve, David M Thissen, Carla M Bann, Nicole Mack, Katherine Treiman, Hanna K Sanoff, Nancy Roach, Brooke E Magnus, Jason He, Laura K Wagner, Rebecca Moultrie, Kathryn D Jackson, Courtney Mann, Lauren A McCormack
OBJECTIVE: To evaluate the psychometric properties of questions that assess patient perceptions of patient-provider communication and design measures of patient-centered communication (PCC). METHODS: Participants (adults with colon or rectal cancer living in North Carolina) completed a survey at 2 to 3 months post-diagnosis. The survey included 87 questions in six PCC Functions: Exchanging Information, Fostering Health Relationships, Making Decisions, Responding to Emotions, Enabling Patient Self-Management, and Managing Uncertainty...
February 10, 2017: Patient Education and Counseling
https://www.readbyqxmd.com/read/28214012/the-endothelium-solves-problems-that-endothelial-cells-do-not-know-exist
#14
REVIEW
John G McCarron, Matthew D Lee, Calum Wilson
The endothelium is the single layer of cells that lines the entire cardiovascular system and regulates vascular tone and blood-tissue exchange, recruits blood cells, modulates blood clotting, and determines the formation of new blood vessels. To control each function, the endothelium uses a remarkable sensory capability to continuously monitor vanishingly small changes in the concentrations of many simultaneously arriving extracellular activators that each provides cues to the physiological state. Here we suggest that the extraordinary sensory capabilities of the endothelium do not come from single cells but from the combined activity of a large number of endothelial cells...
February 14, 2017: Trends in Pharmacological Sciences
https://www.readbyqxmd.com/read/28213812/the-neuroscience-of-human-decision-making-through-the-lens-of-learning-and-memory
#15
Lesley K Fellows
We are called upon to make decisions, large and small, many times a day. Whether in the voting booth, the stock exchange, or the cafeteria line, we identify potential options, estimate and compare their subjective values, and make a choice. Decision-making has only recently become a focus for cognitive neuroscience. The last two decades have seen rapid progress in our understanding of the brain basis of at least some aspects of this rather complex aspect of cognition. This work has provided fresh perspectives on poorly understood brain regions, such as orbitofrontal cortex and ventral striatum...
February 18, 2017: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/28213793/automation-of-peak-tracking-analysis-of-stepwise-perturbed-nmr-spectra
#16
Tommaso Banelli, Marco Vuano, Federico Fogolari, Andrea Fusiello, Gennaro Esposito, Alessandra Corazza
We describe a new algorithmic approach able to automatically pick and track the NMR resonances of a large number of 2D NMR spectra acquired during a stepwise variation of a physical parameter. The method has been named Trace in Track (TINT), referring to the idea that a gaussian decomposition traces peaks within the tracks recognised through 3D mathematical morphology. It is capable of determining the evolution of the chemical shifts, intensity and linewidths of each tracked peak.The performances obtained in term of track reconstruction and correct assignment on realistic synthetic spectra were high above 90% when a noise level similar to that of experimental data were considered...
February 17, 2017: Journal of Biomolecular NMR
https://www.readbyqxmd.com/read/28213468/microencapsulation-of-lefty-secreting-engineered-cells-for-pulmonary-fibrosis-therapy-in-mice
#17
Hongge Ma, Shupei Qiao, Zeli Wang, Shuai Geng, Yufang Zhao, Xiaolu Hou, Weiming Tian, Xiongbiao Chen, Lifen Yao
Idiopathic pulmonary fibrosis (IPF) is a progressive disease that causes unremitting deposition of extracellular matrix proteins, thus resulting in distortion of the pulmonary architecture and impaired gas exchange. Associated with high morbidity and mortality, IPF is generally refractory to current pharmacological therapies. Lefty A, a potent inhibitor of transforming growth factor (TGF)-β signaling, has been shown to have promising antifibrotic ability in vitro for the treatment of renal fibrosis and other potential organ fibroses...
February 17, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28213330/drug-discovery-strategies-in-the-field-of-tumor-energy-metabolism-limitations-by-metabolic-flexibility-and-metabolic-resistance-to-chemotherapy
#18
REVIEW
N D Amoedo, E Obre, R Rossignol
The search for new drugs capable of blocking the metabolic vulnerabilities of human tumors has now entered the clinical evaluation stage, but several projects already failed in phase I or phase II. In particular, very promising in vitro studies could not be translated in vivo at preclinical stage and beyond. This was the case for most glycolysis inhibitors that demonstrated systemic toxicity. A more recent example is the inhibition of glutamine catabolism in lung adenocarcinoma that failed in vivo despite a strong addiction of several cancer cell lines to glutamine in vitro...
February 14, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28213297/retention-of-silver-nano-particles-and-silver-ions-in-calcareous-soils-influence-of-soil-properties
#19
Samaneh Rahmatpour, Mehran Shirvani, Mohammad R Mosaddeghi, Mehdi Bazarganipour
The rapid production and application of silver nanoparticles (AgNPs) have led to significant release of AgNPs into the terrestrial environments. Once released into the soil, AgNPs could enter into different interactions with soil particles which play key roles in controlling the fate and transport of these nanoparticles. In spite of that, experimental studies on the retention of AgNPs in soils are very scarce. Hence, the key objective of this research was to find out the retention behavior of AgNPs and Ag(I) ions in a range of calcareous soils...
February 14, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28213262/one-single-fast-and-robust-capillary-electrophoresis-method-for-the-direct-quantification-of-intact-adenovirus-particles-in-upstream-and-downstream-processing-samples
#20
Ewoud van Tricht, Lars Geurink, Harold Backus, Marta Germano, Govert W Somsen, Cari E Sänger-van de Griend
During development of adenovirus-based vaccines, samples have to be analyzed in order to either monitor the production process or control the quality and safety of the product. An important quality attribute is the total concentration of intact adenoviruses, which currently is determined by quantitative polymerase chain reaction (qPCR) or anion exchange-HPLC. Capillary Electrophoresis (CE) was evaluated as alternative to the current methods with the aim to have one single method that allows reliable and fast quantification of adenovirus particles throughout the full process...
May 1, 2017: Talanta
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