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https://www.readbyqxmd.com/read/28938643/serum-peptidome-profiling-for-the-diagnosis-of-colorectal-cancer-discovery-and-validation-in-two-independent-cohorts
#1
Hao Wang, Chenghua Luo, Shengtao Zhu, Honghong Fang, Qing Gao, Siqi Ge, Haixia Qu, Qingwei Ma, Hongwei Ren, Youxin Wang, Wei Wang
Colorectal cancer (CRC) is one of the most common malignant neoplasms worldwide. Except for the existing fecal occult blood test, colonoscopy and sigmoidoscopy, no widely accepted in vitro diagnostic methods have been available. To identify potential peptide biomarkers for CRC, serum samples from a discovery cohort (100 CRC patients and 100 healthy controls) and an independent validation cohort (91 CRC patients and 91 healthy controls) were collected. Peptides were fractionated by weak cation exchange magnetic beads (MB-WCX) and analysed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS)...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938056/short-term-effects-of-light-quality-on-leaf-gas-exchange-and-hydraulic-properties-of-silver-birch-betula-pendula
#2
Aigar Niglas, Kaisa Papp, Maciej Sekiewicz, Arne Sellin
Leaves have to acclimatize to heterogeneous radiation fields inside forest canopies in order to efficiently exploit diverse light conditions. Short-term effects of light quality on photosynthetic gas exchange, leaf water use and hydraulic traits were studied on Betula pendula Roth shoots cut from upper and lower thirds of the canopy of 39- to 35-year-old trees growing in natural forest stand, and illuminated with white, red or blue light in the laboratory. Photosynthetic machinery of the leaves developed in different spectral conditions acclimated differently with respect to incident light spectrum: the stimulating effect of complete visible spectrum (white light) on net photosynthesis is more pronounced in upper-canopy layers...
September 1, 2017: Tree Physiology
https://www.readbyqxmd.com/read/28937981/cognitive-function-in-patients-with-stable-coronary-heart-disease-related-cerebrovascular-and-cardiovascular-responses
#3
Mathieu Gayda, Vincent Gremeaux, Louis Bherer, Martin Juneau, Joffrey Drigny, Olivier Dupuy, Gabriel Lapierre, Véronique Labelle, Annik Fortier, Anil Nigam
Chronic exercise has been shown to prevent or slow age-related decline in cognitive functions in otherwise healthy, asymptomatic individuals. We sought to assess cognitive function in a stable coronary heart disease (CHD) sample and its relationship to cerebral oxygenation-perfusion, cardiac hemodynamic responses, and [Formula: see text] peak compared to age-matched and young healthy control subjects. Twenty-two young healthy controls (YHC), 20 age-matched old healthy controls (OHC) and 25 patients with stable CHD were recruited...
2017: PloS One
https://www.readbyqxmd.com/read/28937829/nonlinearity-coherence-and-complexity-biophysical-aspects-related-to-health-and-disease
#4
Alberto Foletti, Larissa Brizhik
Biological organisms are complex open dissipative systems whose dynamical stability is sustained due to the exchange of matter, energy and information. Dynamical stability occurs through a number of mechanisms that sustain efficient adaptive dynamics. Such properties of living matter can be the consequence of a self-consistent state of matter and electromagnetic field (EMF). Based on the soliton model of charge transport in redox processes, we describe a possible mechanism of the origin of endogenous EMF and coherence...
September 22, 2017: Electromagnetic Biology and Medicine
https://www.readbyqxmd.com/read/28937817/sanctions-partner-recognition-and-variation-in-mutualism
#5
Jeremy B Yoder, Peter Tiffin
Mutualistic interactions can be stabilized against invasion by noncooperative individuals by putting such "cheaters" at a selective disadvantage. Selection against cheaters should eliminate genetic variation in partner quality-yet such variation is often found in natural populations. One explanation for this paradox is that mutualism outcomes are determined not only by responses to partner performance but also by partner signals. Here, we build a model of coevolution in a symbiotic mutualism, in which hosts' ability to sanction noncooperative symbionts and recognition of symbiont signals are determined by separate loci, as are symbionts' cooperation and expression of signals...
October 2017: American Naturalist
https://www.readbyqxmd.com/read/28937772/terahertz-light-matter-interaction-beyond-unity-coupling-strength
#6
Andreas Bayer, Marcel Pozimski, Simon Schambeck, Dieter Schuh, Rupert Huber, Dominique Bougeard, Christoph Lange
Achieving control over light-matter interaction in custom-tailored nanostructures is at the core of modern quantum electrodynamics. In strongly and ultrastrongly coupled systems, the excitation is repeatedly exchanged between a resonator and an electronic transition at a rate known as the vacuum Rabi frequency ΩR. For ΩR approaching the resonance frequency ωc, novel quantum phenomena including squeezed states, Dicke superradiant phase transitions, the collapse of the Purcell effect, and a population of the ground state with virtual photon pairs are predicted...
September 22, 2017: Nano Letters
https://www.readbyqxmd.com/read/28937762/projected-commutator-diis-method-for-accelerating-hybrid-functional-electronic-structure-calculations
#7
Wei Hu, Lin Lin, Chao Yang
The commutator direct inversion of the iterative subspace (commutator DIIS or C-DIIS) method developed by Pulay is an efficient and the most widely used scheme in quantum chemistry to accelerate the convergence of self consistent field (SCF) iterations in Hartree-Fock theory and Kohn-Sham density functional theory. The C-DIIS method requires the explicit storage of the density matrix, the Fock matrix and the commutator matrix. Hence the method can only be used for systems with a relatively small basis set, such as the Gaussian basis set...
September 22, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28937759/copper-ii-chloro-complex-formation-thermodynamics-and-structure-in-ionic-liquid-1-butyl-3-methylimidazolium-trifluoromethanesulfonate
#8
Ryo Kanzaki, Shuma Uchida, Hitoshi Kodamatani, Takashi Tomiyasu
Metal ions in ionic liquids are laid under an unprecedented reaction field. In order to assess the reaction thermodynamics of metal ions in such a situation, Cu(2+)-chloro complex formation was examined with spectroscopic and calorimetric titrations in an ionic liquid, 1-buthyl-3-methylimidazolium trifluoromethanesulfonate (C4mimTfO). In addition, the effect of the structure of the solvated complexes on the complexation mechanism was investigated with the aid of DFT calculations. Chloro complexation successively proceeded and finally provided a [CuCl4](2‒) species, which is also the final product in conventional molecular solvents...
September 22, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28937740/ab-initio-study-of-the-atomic-level-structure-of-the-rutile-tio2-110-titanium-nitride-tin-interface
#9
Jose Julio Gutierrez Moreno, Michael Nolan
Titanium nitride (TiN) is widely used in industry as a protective coating due to its hardness and resistance to corrosion and can spontaneously form a thin oxide layer when it is exposed to air, which could modify the properties of the coating. With limited understanding of the TiO2 - TiN interfacial system at present, this work aims to describe the structural and electronic properties of oxidized TiN based on a density functional theory (DFT) study of the rutile TiO2 (110) - TiN (100) interface model system, also including Hubbard +U correction on Ti 3d states...
September 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28937637/adsorption-mechanisms-of-dodecylbenzene-sulfonic-acid-by-corn-straw-and-poplar-leaf-biochars
#10
Nan Zhao, Xixiang Yang, Jing Zhang, Ling Zhu, Yizhong Lv
Biochar is an eco-friendly, renewable, and cost-effective material that can be used as an adsorbent for the remediation of contaminated environments. In this paper, two types of biochar were prepared through corn straw and poplar leaf pyrolysis at 300 °C and 700 °C (C300, C700, P300, P700). Brunaer-Emmett-Teller N₂ surface area, scanning electron microscope, elemental analysis, and infrared spectra were used to characterize their structures. These biochars were then used as adsorbents for the adsorption of dodecylbenzene sulfonic acid (DBSA)...
September 22, 2017: Materials
https://www.readbyqxmd.com/read/28937614/a-novel-vav3-homolog-identified-in-lamprey-lampetra-japonica-with-roles-in-lipopolysaccharide-mediated-immune-response
#11
Yanqi Shen, Yishan Zhang, Yinglun Han, Peng Su, Meng Gou, Yue Pang, Qingwei Li, Xin Liu
Vav guanine nucleotide exchange factor 3 (Vav3), a Rho family GTPase, regulates multiple cell signaling pathways including those of T- and B-cell receptors in vertebrates through mediating the activities of the Rho family members. Whether the lamprey possesses Vav3 homolog and what role it plays in immune response remain unknown. Gene cloning, recombinant expression, antibody production and expression pattern analyses were performed to characterize the lamprey Vav3 in the current study. The lamprey Vav3 is closer to jawed vertebrates' Vav3 molecules (about 53% identities in general) than to Vav2 molecules of jawless and jawed vertebrates (about 51% identities in general) in sequence similarity...
September 22, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28937605/production-of-poly-%C3%AE%C2%B5-caprolactone-hydroxyapatite-composite-scaffolds-with-a-tailored-macro-micro-porous-structure-high-mechanical-properties-and-excellent-bioactivity
#12
Jong-Woo Kim, Kwan-Ha Shin, Young-Hag Koh, Min Jin Hah, Jiyoung Moon, Hyoun-Ee Kim
We produced poro-us poly(ε-caprolactone) (PCL)/hydroxyapatite (HA) composite scaffolds for bone regeneration, which can have a tailored macro/micro-porous structure with high mechanical properties and excellent in vitro bioactivity using non-solvent-induced phase separation (NIPS)-based 3D plotting. This innovative 3D plotting technique can create highly microporous PCL/HA composite filaments by inducing unique phase separation in PCL/HA solutions through the non-solvent-solvent exchange phenomenon. The PCL/HA composite scaffolds produced with various HA contents (0 wt %, 10 wt %, 15 wt %, and 20 wt %) showed that PCL/HA composite struts with highly microporous structures were well constructed in a controlled periodic pattern...
September 22, 2017: Materials
https://www.readbyqxmd.com/read/28937283/engineering-rubisco-activase-from-thermophilic-cyanobacteria-into-high-temperature-sensitive-plants
#13
Chukwuma C Ogbaga, Piotr Stepien, Habib-Ur-Rehman Athar, Muhammad Ashraf
In the past decade, various strategies to improve photosynthesis and crop yield, such as leaf morphology, light interception and use efficiency, biochemistry of light reactions, stomatal conductance, carboxylation efficiency, and source to sink regulation, have been discussed at length. Leaf morphology and physiology are tightly coupled to light capturing efficiency, gas exchange capacity, and temperature regulation. However, apart from the photoprotective mechanism of photosystem-II (PSII), i.e. non-photochemical quenching, very low genetic variation in the components of light reactions has been observed in plants...
September 22, 2017: Critical Reviews in Biotechnology
https://www.readbyqxmd.com/read/28936744/cardiac-telocyte-derived-exosomes-and-their-possible-implications-in-cardiovascular-pathophysiology
#14
Mirca Marini, Lidia Ibba-Manneschi, Mirko Manetti
Among cardiac interstitial cells, the recently described telocytes (TCs) display the unique ability to build a supportive three-dimensional network formed by their very long and thin prolongations named telopodes. Cardiac TCs are increasingly regarded as pivotal regulators in intercellular signaling with multiple cell types, such as cardiomyocytes, stem/progenitor cells, microvessels, nerve endings, fibroblasts and immune cells, thus converting the cardiac stromal compartment into an integrated system that may drive either heart development or maintenance of cardiac homeostasis in post-natal life...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28936524/proton-conduction-in-alkali-metal-ion-exchanged-porous-ionic-crystals
#15
Sayaka Uchida, Reina Hosono, Ryo Eguchi, Ryosuke Kawahara, Ryota Osuga, Junko N Kondo, Mitsuhiro Hibino, Noritaka Mizuno
Proton conduction in alkali metal ion-exchanged porous ionic crystals A2[Cr3O(OOCH)6(etpy)3]2[α-SiW12O40]·nH2O [I-A(+)] (A = Li, Na, K, Cs, etpy = 4-ethylpyridine) is investigated. Single crystal and powder X-ray diffraction measurements show that I-A(+) possesses analogous one-dimensional channels where alkali metal ions (A(+)) and water of crystallization exist. Impedance spectroscopy and water diffusion measurements of I-A(+) show that proton conductivities are low (10(-7)-10(-6) S cm(-1)) under low relative humidity (RH), and protons mostly migrate as H3O(+) with H2O as vehicles (vehicle mechanism)...
September 22, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28936498/biredox-ionic-liquids-new-opportunities-toward-high-performance-supercapacitors
#16
C Bodin, E Mourad, D Zigah, S Le Vot, S A Freunberger, F Favier, O Fontaine
Nowadays commercial supercapacitors are based on purely capacitive storage at the porous carbons that are used for the electrodes. However, the limits that capacitive storage imposes on energy density calls to investigate new materials to improve the capacitance of the device. This new type of electrodes (e.g., RuO2, MnO2…) involves pseudo-capacitive faradaic redox processes with the solid material. Ion exchange with solid materials is, however, much slower than the adsorption process in capacitive storage and inevitably leads to significant loss of power...
September 22, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/28936205/homologous-recombination-in-protozoan-parasites-and-recombinase-inhibitors
#17
REVIEW
Andrew A Kelso, Sarah M Waldvogel, Adam J Luthman, Michael G Sehorn
Homologous recombination (HR) is a DNA double-strand break (DSB) repair pathway that utilizes a homologous template to fully repair the damaged DNA. HR is critical to maintain genome stability and to ensure genetic diversity during meiosis. A specialized class of enzymes known as recombinases facilitate the exchange of genetic information between sister chromatids or homologous chromosomes with the help of numerous protein accessory factors. The majority of the HR machinery is highly conserved among eukaryotes...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28935959/the-crystal-structure-of-the-regulatory-domain-of-the-human-sodium-driven-chloride-bicarbonate-exchanger
#18
Carolina M Alvadia, Theis Sommer, Kaare Bjerregaard-Andersen, Helle Hasager Damkier, Michele Montrasio, Christian Aalkjaer, J Preben Morth
The sodium-driven chloride/bicarbonate exchanger (NDCBE) is essential for maintaining homeostatic pH in neurons. The crystal structure at 2.8 Å resolution of the regulatory N-terminal domain of human NDCBE represents the first crystal structure of an electroneutral sodium-bicarbonate cotransporter. The crystal structure forms an equivalent dimeric interface as observed for the cytoplasmic domain of Band 3, and thus establishes that the consensus motif VTVLP is the key minimal dimerization motif. The VTVLP motif is highly conserved and likely to be the physiologically relevant interface for all other members of the SLC4 family...
September 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28935931/asymmetric-electron-hole-decoherence-in-ion-gated-epitaxial-graphene
#19
Kil-Joon Min, Jaesung Park, Wan-Seop Kim, Dong-Hun Chae
We report on asymmetric electron-hole decoherence in epitaxial graphene gated by an ionic liquid. The observed negative magnetoresistance near zero magnetic field for different gate voltages, analyzed in the framework of weak localization, gives rise to distinct electron-hole decoherence. The hole decoherence rate increases prominently with decreasing negative gate voltage while the electron decoherence rate does not exhibit any substantial gate dependence. Quantitatively, the hole decoherence rate is as large as the electron decoherence rate by a factor of two...
September 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28935672/the-dux4-homeodomains-mediate-inhibition-of-myogenesis-and-are-functionally-exchangeable-with-the-pax7-homeodomain
#20
Darko Bosnakovski, Erik A Toso, Lynn M Hartweck, Alessandro Magli, Heather A Lee, Eliza R Thompson, Abhijit Dandapat, Rita C R Perlingeiro, Michael Kyba
Facioscapulohumeral muscular dystrophy (FSHD) is caused by inappropriate expression of the double homeodomain protein, DUX4. DUX4 has bimodal effects, inhibiting myogenic differentiation and blocking MyoD at low levels of expression, and killing myoblasts at high levels. Pax3 and Pax7, which contain related homeodomains, antagonize the cell death phenotype of DUX4 in C2C12 cells, suggesting some type of competitive interaction. Here, we show that effects on differentiation and MyoD expression require the homeodomains but do not require the C-terminal activation domain of DUX4...
September 21, 2017: Journal of Cell Science
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