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Renata C Portela, Nikoly T Fares, Lilian F Machado, Amanda F São Leão, Denise de Freitas, Augusto Paranhos, Tiago S Prata, Carolina P B Gracitelli
PURPOSE: To assess ocular surface disease (OSD) in glaucoma using clinical parameters, self-report assessment and keratograph analysis. METHODS: A total of 30 glaucoma patients and 27 subjects with cataracts (control group) were enrolled in the study. Only glaucoma patients who were using at least 1 topical intraocular pressure (IOP)-lowering medication were included. An ophthalmological examination was performed, including tear break-up time, assessment of conjunctival hyperemia and keratitis, and completion of the Ocular Surface Disease Index (OSDI) questionnaire...
June 18, 2018: Journal of Glaucoma
T Filardi, V Carnevale, R Massoud, C Russo, L Nieddu, F Tavaglione, I Turinese, A Lenzi, E Romagnoli, S Morano
PURPOSE: Patients with type 2 diabetes (T2DM) have increased fracture risk. Osteopontin (OPN) is a protein involved in bone remodeling and inflammation. The aim of this study was to evaluate the association of OPN with fracture prevalence and with metabolic parameters in post-menopausal women with T2DM. METHODS: Sixty-four post-menopausal women with T2DM (age 67.0 ± 7.8 years, diabetes duration 8.9 ± 6.7 years), enrolled in a previous study, were followed up (3...
June 18, 2018: Journal of Endocrinological Investigation
Beata M M Reiber, Mark Tenhagen, Michiel A J M Hunfeld, Huib A Cense, Ahmet Demirkiran
PURPOSE: To determine the effect of an orogastric tube for calibration of the gastric pouch on percentage excess weight loss (%EWL) and percentage total weight loss (%TWL) after laparoscopic Roux-en-Y gastric bypass (LRYGB). MATERIAL AND METHODS: A retrospective case-matched control study in 132 patients. Group A (a 40 French orogastric tube was used to calibrate the gastric pouch) was compared to group B (no orogastric tube was used). All other surgical steps were identical in both groups...
June 18, 2018: Obesity Surgery
Liron Kogan, David Octeau, Zainab Amajoud, Jeremie Abitbol, Ido Laskov, Alex Ferenczy, Manuela Pelmus, Neta Eisenberg, Roy Kessous, Susie Lau, Amber Yasmeen, Walter H Gotlieb, Shannon Salvador
Objective: Evaluation of the impact of lower uterine segment involvement (LUSI) in type II endometrial cancer, and mutational profile of uterine papillary serous carcinomas (UPSC). Methods: Retrospective cohort study comparing patients with type II endometrial cancer with LUSI to patients without LUSI. Genes commonly implicated in carcinogenesis were analyzed in a subgroup of 42 patients with UPSC using next generation sequencing. Results: 83 patients with type II endometrial cancer were included in the study, of these, LUSI was diagnosed in 31...
May 2018: Gynecologic Oncology Reports
Amel Abdalrhim Sulaiman, Sarra O Bushara, Wadie M Elmadhoun, Sufian K Noor, Mutaz Abdelkarim, Ilham Nasr Aldeen, Meissa M Osman, Ahmed O Almobarak, Heitham Awadalla, Mohamed H Ahmed
Background: Child malnutrition is a major public health problem in developing countries. Therefore, the aim of this study was to estimate the prevalence of undernutrition among children <5 years in River Nile state (RNS) in North Sudan. Subjects and Methods: A cross-sectional household survey was done in four localities in RNS. Using Multistage Cluster sampling, 1635 under 5 years' children had participated. Pretested questionnaire and anthropometric measures were used during data collection...
January 2018: Journal of Family Medicine and Primary Care
Arun Fotedar, Jasjit Singh Bhasin, Ashok Chakravarty, Avinash Kulkarni, Gaurav Bhalla, Fahmina Anwar, Shashidhar Rao
Introduction: Iron deficiency anemia represents 3rd largest disease burden, with an estimated 6.9 billion disability-adjusted life years. Iron-fortified cereals (IFIC) can contribute substantially in preventing iron deficiency anemia and maintaining an adequate body iron status. The aim of this study is to assess the effectiveness of IFIC intake along with other complementary food/s on the hemoglobin (hb) level of children from 12 to 24 months of age. Materials and Methods: A cross-sectional study was conducted from November 2015 to February 2016 in three pediatric outpatient clinics of New Delhi, India...
January 2018: Journal of Family Medicine and Primary Care
Timo Jan Oberstein, Lava Taha, Philipp Spitzer, Janina Hellstern, Martin Herrmann, Johannes Kornhuber, Juan Manuel Maler
The neuropathological hallmarks of Alzheimer's disease (AD), i.e., neuritic plaques and neurofibrillary tangles, consist of beta amyloid peptides (Aβ) and hyperphosphorylated Tau. These are accompanied by reactive microglia and astrocytes in the vicinity of the neuritic plaques and by changes to the peripheral immune system, e.g., an increase of the pro-inflammatory cytokines IL-1β, IL-6, and TNF-α in the peripheral blood. To address a potential involvement of peripheral T helper cell (Th ) subsets in AD, we conducted a case control study with 54 individuals with AD dementia ( n  = 14), with mild cognitive impairment (MCI) due to AD (MCIAD , n  = 14), with MCI unlikely due to AD (MCIother , n  = 13), and controls without cognitive impairment (controls, n  = 13)...
2018: Frontiers in Immunology
Lijun Wang, Ting Tian
Objective : Subjective cognitive decline (SCD), also known as significant memory concern (SMC), has been suggested as a manifestation of Alzheimer's Disease (AD) preceding mild cognitive impairment (MCI). This study assessed the impact of gender on cognition, amyloid accumulation, the volumes of hippocampus, entorhinal cortex (EC), fusiform and medial temporal lobe (MTA) and cerebrospinal fluid (CSF) pathology biomarkers in patients reporting SMC. Methods : Twenty-nine males (mean age ± SD: 72.3 ± 5.7 years) and 40 females (mean age ± SD: 71...
2018: Frontiers in Aging Neuroscience
Tomoko Kobayashi, Michihiro Kono, Mutsumi Suganuma, Hirotaka Akita, Ayaka Takai, Kiyohiro Tsutsui, Yu Inasaka, Takuya Takeichi, Yoshinao Muro, Masashi Akiyama
Dyschromatosis symmetrica hereditaria (DSH) is one of the genetic pigmentation disorders and shows characteristic mixture of hyper- and hypo-pigmented small macules on the extremities. Heterozygous mutations in the adenosine deaminase acting on RNA1 gene ( ADAR1 ) cause DSH. In the present study, we report five cases of DSH and identify a distinct known mutation in each patient. Furthermore, we review previously described cases with the five ADAR1 mutations found in the present study. We reviewed clinical and molecular findings in the present and previously reported cases and found an identical mutation can result in various phenotypic severities, even in one family...
May 2018: Nagoya Journal of Medical Science
Veronica Guardabassi, Carlo Tomasetto
BACKGROUND: Obesity is a highly stigmatizing condition, and reduced cognitive functioning is a stereotypical trait ascribed to individuals with obesity. In the present work, we tested the hypothesis that stereotype threat (i.e., a depletion of working memory resources due to the fear of confirming a negative self-relevant stereotype when a stereotype-related ability is assessed) contributes to cognitive deficits in individuals with obesity. METHODS: Computerized tests of (a) working memory and (b) probabilistic learning-an ability unrelated with working memory-were administered to a community sample of 131 adults...
June 18, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
Xiqiang Wang, Dandan Yang, Jing Liu, Xiude Fan, Aiqun Ma, Ping Liu
The double-stranded DNA (dsDNA) which is scaffold of neutrophil extracellular traps (NETs) has been reported to be associated with the occurrence of major adverse cardiovascular events (MACEs) in patients with coronary atherosclerosis. However, the relationship between the dsDNA and the occurrence of MACEs in patients with ST-segment elevated myocardial infarction (STEMI) remains unclear. In this study, 142 consecutive STEMI patients were admitted to medical institutions. Blood from the infarct-related coronary artery (ICA) and peripheral artery (PA) were obtained during percutaneous coronary intervention...
June 18, 2018: Scientific Reports
Lennart Tonneijck, Marcel H A Muskiet, Jos W Twisk, Mark H H Kramer, A H Jan Danser, Jaap A Joles, Mark M Smits, Daniël H van Raalte
The prolonged treatment effects of a short-acting GLP-1RA (glucagon-like peptide-1 receptor agonist), such as lixisenatide, on fasting and postprandial systemic hemodynamics in type 2 diabetes mellitus patients are unknown. In this secondary analysis, we included 34 overweight insulin glargine-treated type 2 diabetes mellitus patients (mean±SD age, 62±7 years; HbA1c , 8.0±0.9%; systolic blood pressure [BP], 133.9±16.1 mm Hg; diastolic BP, 75.4±8.39 mm Hg) that were randomized to once-daily lixisenatide 20 μg or once-daily titrated insulin glulisine for 8 weeks...
June 18, 2018: Hypertension
Sara Jiménez, José Antonio Rubio, Julia Álvarez, José Luis Lázaro-Martínez
BACKGROUND AND OBJECTIVE: The aim of this study was to assess the risk factors associated to recurrent diabetic foot ulcers after implementing a new preventive comprehensive foot care (CFC) program carried out by a podiatrist and an endocrinologist at a multidisciplinary diabetic foot unit (MDFU) and its potential impact in decreasing recurrent ulcers. MATERIAL AND METHODS: A retrospective cohort study including consecutive patients who attended the MDFU for the first time from 2008 to 2014 complaining of a diabetic foot ulcer that finally healed...
June 15, 2018: Endocrinología, Diabetes y Nutrición
Adalberta Lima Martins, Rhaisa Almeida Volpato, Maria da Penha Zago-Gomes
BACKGROUND: The epidemiology of inflammatory bowel disease (IBD) varies in different countries. This study aimed to assess phenotype, medications, prevalence and incidence of IBD in the State of Espírito Santo, Brazil. METHODS: Patients with IBD who utilized the Public Medication-Dispensing System of the Department of Health of Espírito Santo, between August 2012 and July 2014. Of 1484 active patients, 1048 were analyzed, which included patients of all ages. RESULTS: The prevalence of IBD was 38...
June 18, 2018: BMC Gastroenterology
Ebru Atike Ongun, Oguz Dursun, Mehmet Saim Kazan, Banu Nur, Ercan Mıhçı
Background/aim: Declined morbidity rates after craniosynostosis surgery indicate bypassing the pediatric intensive care unit (PICU) course to minimize treatment costs and bed usage. The aim of this study is to examine the incident rates of PICU admission and assess its necessity. Materials and methods: A retrospective analysis of 41 patients (operated on by open surgical techniques) between July 2011 and December 2015 was carried out. Intraoperative/postoperative vital signs, hemodynamic and metabolic parameters, estimated blood loss (EBVloss), blood transfusions, length of PICU, and hospitalizations were recorded...
June 14, 2018: Turkish Journal of Medical Sciences
Po-Hsun Lei, I-Jen Chen, Jia-Jan Chen, Po-Chun Yang, Yan-Hua Gong
We synthesized a silver nanoparticle/zinc oxide (Ag NP/ZnO) thin film by using spin-coating technology. The treatment solution for Ag NP/ZnO thin film deposition contained zinc acetate (Zn(CH₃COO)₂), sodium hydroxide (NaOH), and silver nitrate (AgNO₃) aqueous solutions. The crystalline characteristics, surface morphology, content of elements, and reflectivity of the Ag NPs/ZnO thin film at various concentrations of the AgNO₃ aqueous solution were investigated using X-ray diffraction, scanning electron microscopy, energy-dispersive X-ray spectroscopy, atomic force microscopy, and ultraviolet⁻visible⁻near infrared spectrophotometry...
June 15, 2018: Materials
Isidro Palos, Julieta Luna-Herrera, Edgar E Lara-Ramírez, Alejandra Loera-Piedra, Emanuel Fernández-Ramírez, Ma Guadalupe Aguilera-Arreola, Alma D Paz-González, Antonio Monge, Baojie Wan, Scott Franzblau, Gildardo Rivera
Tuberculosis continues to be a public health problem in the world, and drug resistance has been a major obstacle in its treatment. Quinoxaline 1,4-di- N -oxide has been proposed as a scaffold to design new drugs to combat this disease. To examine the efficacy of this compound, this study evaluates methyl, ethyl, isopropyl, and n-propyl esters of quinoxaline 1,4-di- N -oxide derivatives in vitro against Mycobacterium tuberculosis (pansusceptible and monoresistant strains). Additionally, the inhibitory effect of esters of quinoxaline 1,4-di- N -oxide on M...
June 15, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Anna-Maria Kuivalainen, Janne Pitkäniemi, Tom Widenius, Erkki Elonen, Per Rosenberg
Background Previously we found that pre-procedural nervousness and tension (translated into English as "anxiety"), assessed on a non-validated five-point scale, correlated with pain intensity of the various stages of bone marrow aspiration and biopsy (BMAB). The fewer the previous BMAB procedures the stronger the pain from a repeated procedure. The primary purpose of the present observational study is to evaluate the state of anxiety just before BMAB and to find out whether it affects the pain experiences during the various stages of the BMAB procedure...
December 29, 2017: Scandinavian Journal of Pain
S Zoёga, T Aspelund, G Sigurdsson, S E Ward, H Sveinsdóttir, S Gunnarsdóttir
Aims To determine if pain is assessed, documented, and treated in a university hospital according to recommended practice. Methods A cross-sectional descriptive study, conducted in 23 medical and surgical wards in a university hospital. Participants were patients hospitalized for at least 24hours, ≥18 years of age, and able to participate. Data were collected from patients with a questionnaire (APS-POQ-R), from their medical records, and from Therapy®, the hospital medication system. Results The response rate was 73%...
December 29, 2017: Scandinavian Journal of Pain
B Bhowmik, F Afsana, T Ahmed, T Siddiquee, T Ahmed, F Pathan, H Mahtab, A K A Khan
OBJECTIVE: The aim of this study was to evaluate the level of knowledge about gestational diabetes mellitus (GDM) in Bangladeshi people. STUDY DESIGN: Cross-sectional study. METHODS: This study involving 1374 participants was conducted in 15 outpatient clinics of Diabetic Association of Bangladesh and its affiliated associations, Bangabandhu Sheikh Mujib Medical University and four medical college hospitals in Bangladesh from August 2015 to December 2015...
June 15, 2018: Public Health
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