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https://www.readbyqxmd.com/read/28735463/impact-of-pioglitazone-on-bone-mineral-density-and-bone-marrow-fat-content
#1
L M Pop, I Lingvay, Q Yuan, X Li, B Adams-Huet, N M Maalouf
Pioglitazone use is associated with an increased risk of fractures. In this randomized, placebo-controlled study, pioglitazone use for 12 months was associated with a significant increase in bone marrow fat content at the femoral neck, accompanied by a significant decrease in total hip bone mineral density. The change in bone marrow fat with pioglitazone use was predominantly observed in female vs. male participants. INTRODUCTION: Use of the insulin sensitizer pioglitazone is associated with greater fracture incidence, although the underlying mechanisms are incompletely understood...
July 22, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28735300/caveolin-1-expression-as-a-prognostic-marker-in-triple-negative-breast-cancers-of-asian-women
#2
Joe Yeong, Aye Aye Thike, Murasaki Ikeda, Jeffrey Chun Tatt Lim, Bernett Lee, Seigo Nakamura, Jabed Iqbal, Puay Hoon Tan
BACKGROUND: Triple-negative breast cancers (TNBCs) are defined by their lack of oestrogen receptor, progesterone receptor and epidermal growth factor receptor 2. Although heterogeneous, the majority are aggressive and treatment options are limited. Caveolin acts as tumour suppressor or promoter depending on the cancer type. AIM: In this study, we aimed to determine if the expression levels of the candidate biomarker caveolin-1 on stromal or tumour cells were associated with clinicopathological parameters and disease outcomes in TNBCs from an ethnically diverse cohort of Asian women...
July 22, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28735155/impact-of-restrictive-fluid-protocol-on-hypoxemia-after-aneurysmal-subarachnoid-hemorrhage
#3
Claire-Marie Drevet, Nicolas Opprecht, Abdelouaïd Nadji, Sebastien Mirek, Serge Aho, Frederic Ricolfi, Claude Girard, Bélaïd Bouhemad
PURPOSE: In patients with aneurysmal subarachnoid hemorrhage (aSAH), acute cardiac dysfunction and triple-H-therapy, can lead to hypoxemia. Our aim was to assess impact of a protocoled fluid restrictive approach on hypoxemia in these patients. METHODS: We included prospectively ICU patients with aSAH admitted within 24h after the bleed. The study was divided into 2 phases. The first phase, from January to December 2012, was designated as control group (group C)...
July 17, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28735123/surgery-for-cerebellar-hemorrhage-a-nsqip-database-analysis-of-patient-outcomes-and-factors-associated-with-30-day-mortality-and-prolonged-ventilation
#4
Gregory D Arnone, Darian R Esfahani, Matt Wonais, Prateek Kumar, Justin K Scheer, Ali Alaraj, Sepideh Amin-Hanjani, Fady T Charbel, Ankit I Mehta
OBJECTIVE: Primary cerebellar hemorrhage accounts for 10% of all intracranial hemorrhages. Given the confined space of the posterior fossa, cerebellar hemorrhage management sometimes necessitates suboccipital decompression and hematoma evacuation. In this study, we examine outcomes following surgery for primary cerebellar hemorrhage, and identify risk factors associated with adverse outcomes. METHODS: A retrospective review of the 2005-2014 ACS-NSQIP database was performed, with CPT Code 61315 (suboccipital craniectomy or craniotomy for evacuation of cerebellar hemorrhage) queried between 2005 and 2014...
July 19, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28734885/clinical-impact-of-baseline-right-bundle-branch-block-in-patients-undergoing-transcatheter-aortic-valve-replacement
#5
Vincent Auffret, John G Webb, Hélène Eltchaninoff, Antonio J Muñoz-García, Dominique Himbert, Corrado Tamburino, Luis Nombela-Franco, Fabian Nietlispach, César Morís, Marc Ruel, Antonio E Dager, Vicenç Serra, Asim N Cheema, Ignacio J Amat-Santos, Fábio Sandoli de Brito, Pedro Alves Lemos, Alexandre Abizaid, Rogério Sarmento-Leite, Eric Dumont, Marco Barbanti, Eric Durand, Juan H Alonso Briales, Alec Vahanian, Claire Bouleti, Sebastiano Immè, Francesco Maisano, Raquel Del Valle, Luis Miguel Benitez, Bruno García Del Blanco, Rishi Puri, François Philippon, Marina Urena, Josep Rodés-Cabau
OBJECTIVES: This study sought to assess the influence of baseline right bundle branch block (RBBB) on all-cause and cardiovascular mortality as well as sudden cardiac death (SCD) among patients undergoing transcatheter aortic valve replacement (TAVR). BACKGROUND: Few data exist regarding the late clinical impact of pre-existing RBBB in TAVR recipients. METHODS: A total of 3,527 patients (mean age 82 ± 8 years, 50.1% men) were evaluated according to the presence of RBBB on baseline electrocardiography...
July 13, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28734615/highly-cross-linked-polyethylene-reduces-osteolysis-incidence-and%C3%A2-wear-related-reoperation-rate-in-cementless-total-hip-arthroplasty%C3%A2-compared-with-conventional-polyethylene-at%C3%A2-a%C3%A2-mean%C3%A2-12-year-follow-up
#6
Manabu Tsukamoto, Toshiharu Mori, Hideo Ohnishi, Soshi Uchida, Akinori Sakai
BACKGROUND: A number of studies on total hip arthroplasty have compared highly cross-linked polyethylene (HXLPE) with conventional polyethylene (CPE) liners beyond 10 years. However, the impact of HXLPE on the wear-related reoperation rate is unclear. The purpose of this study was to evaluate the clinical advantage of using a single manufacturer's HXLPE in terms of reducing the reoperation rate. METHODS: The study was a follow-up retrospective cohort study over a mean of 12 years that examined patients aged 45-70 years with cementless total hip arthroplasty using a 26-mm-diameter cobalt-chromium head...
July 8, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28734186/bilateral-vocal-cord-palsy-after-total-thyroidectomy-a-new-treatment-case-reports
#7
Fong-Fu Chou, Cheng-Ming Hsu, Chi-Chih Lai, Yi-Chia Chan, Shun-Yu Chi
INTRODUCTION: Dyspnea due to bilateral vocal cord palsy after total thyroidectomy (BVCPATT) is a life-threatening complication; nevertheless, we try to avoid tracheotomy. METHODS: Using normalized glottal area (NGA), we retrospectively studied 14 patients with BVCPATT. Nine patients without dyspnea were treated conservatively, while five with dyspnea received immediate bilevel positive air-way pressure (BiPAP) treatment. Both right and left recurrent nerves were grossly intact during surgery...
June 30, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28733929/outcomes-of-ahmed-glaucoma-valve-implantation-for-steroid-induced-elevated-intraocular-pressure-in-patients-with-retinitis-pigmentosa
#8
Umit Eksioglu, Caglar Oktem, Gulten Sungur, Mehmet Yakin, Gulizar Demirok, Firdevs Ornek
PURPOSE: To evaluate the outcomes of Ahmed glaucoma valve (AGV) in the management of elevated intraocular pressure (IOP) secondary to steroid use for macular edema in patients with retinitis pigmentosa (RP). METHODS: A total of nine eyes of five patients were evaluated retrospectively. Complete success was defined as IOP ≤ 21 mmHg without glaucoma medications, while qualified success was defined as IOP ≤ 21 mmHg with glaucoma medications. RESULTS: Mean age at surgery was 25...
July 21, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28733201/prone-percutaneous-nephrolithotomy-does-bolster-orientation-matter
#9
Daniel Sagalovich, Cecilia Besa, Timothy Tran, Haresh Thummar, Blake Le Grand, Bachir Taouli, Mantu Gupta
OBJECTIVES: To assess whether horizontal versus vertical bolster orientation affects kidney position during prone percutaneous nephrolithotomy as this could impact the need for supracostal access and therefore the likelihood of pleural injury. METHODS: In a prospective trial, ten subjects with 20 renal units underwent magnetic resonance imaging in prone position with standard cylindrical bolsters oriented vertically and then horizontally. Vertical bolsters were placed along the lateral aspect of the chest...
July 18, 2017: Urology
https://www.readbyqxmd.com/read/28733185/fdg-pet-parameters-as-predictors-of-pathologic-response-and-nodal-clearance-in-patients-with-stage-iii-non-small-cell-lung-cancer-receiving-neoadjuvant-chemoradiation-and-surgery
#10
Andrea L Arnett, Ann T Packard, Kristin Mara, Aaron S Mansfield, Dennis A Wigle, Michael G Haddock, Sean S Park, Kenneth R Olivier, Yolanda I Garces, Kenneth W Merrell
OBJECTIVE: Pathologic complete response (pCR) following neoadjuvant chemoradiation (CRT) is associated with improved outcomes in stage III non-small cell lung cancer. Conflicting results exist regarding the value of (18)F-fluorodeoxyglucose positron emission tomography (FDG-PET) in predicting pCR. This study evaluated the association between post-CRT FDG-PET and pCR using novel FDG-PET parameters. METHODS AND MATERIALS: This retrospective study included patients treated with CRT and resection...
April 19, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28733081/synapsin-antibodies-in-psychiatric-and-neurological-disorders-prevalence-and-clinical-findings
#11
Markus Höltje, Robert Mertens, Morten Brix Schou, Sverre Georg Saether, Elena Kochova, Sven Jarius, Harald Prüss, Lars Komorowski, Christian Probst, Friedemann Paul, Judith Bellmann-Strobl, Daniel Gitler, Fabio Benfenati, Johannes Piepgras, Gudrun Ahnert-Hilger, Klemens Ruprecht
OBJECTIVE: To study the prevalence of autoantibodies to synapsin in patients with psychiatric and neurological disorders and to describe clinical findings in synapsin antibody positive patients. METHODS: Sera of 375 patients with different psychiatric and neurological disorders and sera of 97 healthy controls were screened (dilution 1:320) for anti-synapsin IgG using HEK293 cells transfected with rat synapsin Ia. Positive sera were further analyzed by immunoblots with brain tissue from wild type and synapsin knock out mice and with HEK293 cells transfected with human synapsin Ia and Ib...
July 18, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28732373/impact-of-preoperative-diagnostic-turbt-on-progression-free-survival-in-patients-with-pathological-high-grade-stage-t3-t4-bladder-urothelial-carcinoma
#12
Haichao Huang, Zhenhua Liu, Xin Li, Wei Li, Jinchun Xing, Wei Yu, Jie Jin
Transurethral bladder tumor resection (TURBT) reportedly increases the circulating tumor cell count in patients with urothelial carcinoma of the bladder (UCB). To determine whether diagnostic TURBT leads to poorer progression-free survival (PFS) than diagnostic cystoscopic biopsy, we retrospectively reviewed the records of 96 consecutive primary pathological high-grade, stage T3/T4 UCB patients treated with radical cystectomy (RC) between January 2009 to December 2013. Clinicopathological features were collected from the medical records...
July 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28732372/combined-ki67-and-ercc1-for-prognosis-in-non-keratinizing-nasopharyngeal-carcinoma-underwent-chemoradiotherapy
#13
Ying Lu, Haixin Huang, Min Kang, Min Yi, Hui Yang, Sibei Wu, Rensheng Wang
This study aimed to assess the predictive value of combined Ki67 and ERCC1 in distant metastasis-free nasopharyngeal carcinoma. 334 such cases were retrospectively assessed. Immunohistochemistry was used to evaluate Ki67 and ERCC1 protein levels in tumor tissues. Associations of Ki67 and ERCC1 amounts with clinical characteristics and survival were analyzed. Medium follow-up was 48.7 months; overall survival (OS), disease-free survival (DFS), distant metastasis-free survival (DMFS), and local recurrence-free survival (LRFS) were 91...
July 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28732365/preoperative-neutrophil-to-lymphocyte-ratio-and-tumor-related-factors-to-predict-microvascular-invasion-in-patients-with-hepatocellular-carcinoma
#14
Yanlong Yu, Jiuling Song, Ran Zhang, Zhonghua Liu, Qiang Li, Ying Shi, Ying Chen, Jinming Chen
Small hepatocellular carcinoma (HCC) is less invasive and has a better prognosis, but it still has a high recurrence rate. Microvascular invasion (MVI), as a poor prognostic indicator, is of great importance for treating of patients with HCC. The objective of the present study was to evaluate the predictive value of preoperative neutrophil-to-lymphocyte ratio and possible clinical parameters to MVI in patients with HCC. A total of 157 operable patients with HCC having a tumor diameter of less than or equal to 5 cm were enrolled in this study...
July 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28732137/prevalence-of-sacroiliitis-in-inflammatory-bowel-disease-using-a-standardized-ct-scoring-system
#15
Jonathan Chan, Ismail Sari, David Salonen, Mark S Silverberg, Nigil Haroon, Robert D Inman
OBJECTIVES: There is an increasing emphasis on early identification and treatment of ankylosing spondylitis (AS) of which the hallmark is sacroiliitis. Patients with inflammatory bowel disease (IBD) are at increased risk of AS and often receive CT scans of their abdomen affording clinicians the opportunity to determine the presence of sacroiliitis. Previous studies using CT have relied only on radiologist's gestalt or a non-validated adaptation of the mNY criteria. Our aim is to assess the prevalence of sacroiliitis in IBD using a validated screening tool and to determine how frequently these patients are referred for rheumatologic evaluation...
July 21, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28732058/the-role-of-a-fads1-polymorphism-in-the-association-of-fatty-acid-blood-levels-bmi-and-blood-pressure-in-young-children-analyses-based-on-path-models
#16
Maike Wolters, Carmen Dering, Alfonso Siani, Paola Russo, Jaakko Kaprio, Patrizia Risé, Luis A Moreno, Stefaan De Henauw, Kirsten Mehlig, Toomas Veidebaum, Denés Molnár, Michael Tornaritis, Licia Iacoviello, Yannis Pitsiladis, Claudio Galli, Ronja Foraita, Claudia Börnhorst
BACKGROUND: The recent obesity epidemic in children also showed an increase in the prevalence of hypertension. As blood pressure (BP) is associated with (long-chain) polyunsaturated fatty acids (LC PUFA), genetic variation in desaturase enzymes being involved in the synthesis of LC PUFA may be associated with BP. This study aimed to investigate the direct effects (independent of mediating variables) and indirect effects (mediated through intermediate variables) of a common variant in the FADS1 gene, rs174546, known to affect delta-5 desaturase (D5D) activity on PUFA level, body mass index (BMI) and BP...
2017: PloS One
https://www.readbyqxmd.com/read/28732014/association-of-time-serial-changes-in-ambient-particulate-matters-pms-with-respiratory-emergency-cases-in-taipei-s-wenshan-district
#17
Jer-Hwa Chang, Shih-Chang Hsu, Kuan-Jen Bai, Shau-Ku Huang, Chin-Wang Hsu
Ambient air pollution poses a significant risk for a group of common and often debilitating respiratory diseases, but its direct impact on cause-specific respiratory diseases using emergency room visit (ERV) as an indicator remains to be fully explored. In this study, we conducted a time-series study of ambient PM2.5, NO2, SO2 and their association with ERV for asthma, COPD and pneumonia in a four-year time span. Relative risks for ERV as per log increase in the level of ambient pollutants with time lags of up to 10 days were calculated, using a generalized additive model of Poisson regression...
2017: PloS One
https://www.readbyqxmd.com/read/28731873/health-related-quality-of-life-in-iranian-adult-men-with-severe-hemophilia
#18
Mohammad Faranoush, Ehsan Shahverdi, Raheb Qorbani, Mostafa Moghaddam
: Health-related quality of life (HRQOL) assessment should be part of the regular clinical assessment of persons with hemophilia. This study assessed quality of life of severe hemophilia patients (Type A) in Tehran comprehensive hemophilia care center. This cross-sectional study was done in 2016 and 84 men aged over 20 years with severe hemophilia (Type A) were assessed. All patients have been treated over 10 years at the comprehensive hemophilia care center, Iran. The HRQOL assessment includes the A36 Hemophilia-QOL questionnaire, sociodemographical and clinical characteristics...
July 20, 2017: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/28731651/fluid-balance-and-length-of-mechanical-ventilation-in-children-admitted-to-a-single-pediatric-intensive-care-unit
#19
Solange Vidal, Augusto Pérez, Pablo Eulmesekian
INTRODUCTION: Associations between cumulative fluid balance and a prolonged duration of assisted mechanical ventilation have been described in adults. The aim of this study was to evaluate whether fluid balance in the first 48 hours of assisted mechanical ventilation initiation was associated with a prolonged duration of this process among children in the Pediatric Intensive Care Unit (PICU). METHODS: Retrospective cohort of patients in the PICU of Hospital Italiano de Buenos Aires, between 1/1/2010 and 6/30/2012...
August 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28731609/dietary-sodium-and-potassium-intake-and-their-association-with-blood-pressure-in-a-non-hypertensive-iranian-adult-population-isfahan-salt-study
#20
Noushin Mohammadifard, Arsalan Khaledifar, Alireza Khosravi, Fatemeh Nouri, Ali Pourmoghadas, Awat Feizi, Ahmad Esmaillzadeh, Nizal Sarrafzadegan
AIM: The association of sodium (Na) and potassium (K) intake with blood pressure (BP) is an ongoing debate, especially in central Iran. We aimed to examine the mean Na and K intake, major sources of Na and the relationship between BP and dietary and urinary Na and K. METHODS: This cross-sectional study was performed in central Iran in 2013-2014. A total of 796 non-hypertensive adults aged >18 years were randomly recruited. The semi-quantitative food frequency questionnaire was used to assess dietary Na and K intake...
July 2017: Nutrition & Dietetics: the Journal of the Dietitians Association of Australia
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