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https://www.readbyqxmd.com/read/29031219/long-term-correlation-of-subthalamic-beta-band-activity-with-motor-impairment-in-patients-with-parkinson-s-disease
#1
Wolf-Julian Neumann, Franziska Staub-Bartelt, Andreas Horn, Julia Schanda, Gerd-Helge Schneider, Peter Brown, Andrea A Kühn
OBJECTIVES: To investigate the long term association of subthalamic beta activity with parkinsonian motor signs. METHODS: We recruited 15 patients with Parkinson's disease undergoing subthalamic DBS for local field potential recordings after electrode implantation, and at 3 and 8months post-operatively using the implantable sensing enabled Activa PC+S (Medtronic). Three patients dropped out leaving 12 patients. Recordings were conducted ON and OFF levodopa at rest...
September 20, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29031038/isocitrate-dehydrogenase-mutations-are-better-prognostic-marker-than-o6-methylguanine-dna-methyltransferase-promoter-methylation-in-glioblastomas-a-retrospective-single-centre-molecular-genetics-study-of-gliomas
#2
M Houdova Megova, J Drábek, Z Dwight, R Trojanec, V Koudeláková, J Vrbková, O Kalita, S Mlcochova, M Rabcanova, M Hajdúch
BACKGROUND: Mutations in isocitrate dehydrogenase 1 and 2 (IDH1/2) are a promising prognostic biomarker of gliomas. The purpose of our study was to examine the clinical prognostic properties of IDH1/2 mutations in a glioma patient cohort from the Czech Republic using an improved platform for simple and reliable IDH genotyping. MATERIAL AND METHODS: We retrospectively analyzed a group of 145 glioma patients by testing for the three most frequent IDH mutations, IDH1 R132H, IDH1 R132C, and IDH2 R172K, through the competitive amplification of differentially melting amplicons (CADMA) polymerase chain reaction (PCR)...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/29029085/impairment-of-elastic-properties-of-the-aorta-in-bicuspid-aortic-valve-relationship-between-biomolecular-and-aortic-strain-patterns
#3
Luca Longobardo, Maria Ludovica Carerj, Gabriele Pizzino, Alessandra Bitto, Maurizio Cusma Piccione, Marta Zucco, Lilia Oreto, Maria Chiara Todaro, Maria Pia Calabrò, Francesco Squadrito, Gianluca Di Bella, Giuseppe Oreto, Bijoy K Khandheria, Scipione Carerj, Concetta Zito
Aims: Bicuspid aortic valve (BAV) is associated with aortic wall alterations. We aimed to detect any correlation between aortic elasticity and genetic and biomolecular patterns of elastin. Methods and results: Forty-nine BAV patients (mean age: 38 ± 17.05) were prospectively enrolled. A blood sample was drawn for analysis of a single nucleotide polymorphism of elastin gene (ELN rs2071307) responsible for misfolding of elastin, and for the amount of elastin soluble fragments (ESF) in the plasma...
September 23, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29029041/long-term-effects-of-berberis-thunbergii-ranunculales-berberidaceae-management-on-ixodes-scapularis-acari-ixodidae-abundance-and-borrelia-burgdorferi-spirochaetales-spirochaetaceae-prevalence-in-connecticut-usa
#4
Scott C Williams, Megan A Linske, Jeffrey S Ward
Japanese barberry (Berberis thunbergii de Candolle; Ranunculales: Berberidaceae) is an exotic invasive shrub that escaped cultivation in the United States and is now permanently established in many eastern and midwestern states. This study examined the long-term impacts of Japanese barberry management on blacklegged tick (Ixodes scapularis Say; Acari: Ixodidae) abundances and associated prevalence of Borrelia burgdorferi (Johnson, Schmid, Hyde, Steigerwalt, and Brenner; Spirochaetales: Spirochaetaceae), the etiologic agent of Lyme disease...
September 26, 2017: Environmental Entomology
https://www.readbyqxmd.com/read/29029030/outcomes-of-surgery-for-infective-endocarditis-a-single-centre-experience-of-801-patients
#5
Sameh M Said, Zaid M Abdelsattar, Hartzell V Schaff, Kevin L Greason, Richard C Daly, Alberto Pochettino, Lyle D Joyce, Joseph A Dearani
OBJECTIVES: Infective endocarditis (IE) remains a life-threatening disease, despite the improvement in diagnostic and therapeutic measures. We reviewed our outcomes for all adults who underwent surgery for endocarditis at our centre. METHODS: Between January 1995 and December 2013, 801 patients [586 men (73%)] underwent surgery for IE. Mean age was 60 ± 14.7 years. Native endocarditis (NE) was present in 372 patients (46%), and 379 (47%) patients had active IE...
October 3, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29029001/comparative-study-of-bicuspid-vs-tricuspid-aortic-valve-stenosis
#6
Geoffrey D Huntley, Jeremy J Thaden, Said Alsidawi, Hector I Michelena, Joseph J Maleszewski, William D Edwards, Christopher G Scott, Sorin V Pislaru, Patricia A Pellikka, Kevin L Greason, Naser M Ammash, Joseph F Malouf, Maurice Enriquez-Sarano, Vuyisile T Nkomo
Aims: To examine differences and similarities in bicuspid aortic valve (BAV) and tricuspid aortic valve (TAV) stenosis occurring during the same age and whether any differences impact outcomes following aortic valve replacement (AVR). Methods and results: An age-matched cohort of 198 BAV stenosis and 198 TAV stenosis patients was identified from 888 consecutive patients undergoing AVR for severe AS. Mean age 68 ± 6 years; 68% male. Patients with BAV were less likely to have multiple comorbidities, as measured by the Charlson Comorbidity Index (CCI) >2 (3 vs...
October 3, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29028560/racial-discrimination-and-cortisol-output-a-meta-analysis
#7
REVIEW
Kevin M Korous, José M Causadias, Deborah M Casper
RATIONALE: Although the relation between stress and physiology is well documented, attempts at understanding the link between racial discrimination and cortisol output, specifically, have produced mixed results, likely due to study characteristics such as racial/ethnic composition of the samples (e.g., African American, Latino), measures of discrimination, and research design (e.g., cross-sectional, experimental). OBJECTIVES: To estimate the overall association between racial discrimination and cortisol output among racial/ethnic minority individuals and to determine if the association between racial discrimination and cortisol output is moderated by age, race/ethnicity, type of discrimination measure, sex, and research design...
September 27, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/29028488/prenatal-phthalate-exposure-and-placental-size-and-shape-at-birth-a-birth-cohort-study
#8
Yuan-Duo Zhu, Hui Gao, Kun Huang, Yun-Wei Zhang, Xiu-Xiu Cai, Hui-Yuan Yao, Lei-Jing Mao, Xing Ge, Shan-Shan Zhou, Yuan-Yuan Xu, Zhong-Xiu Jin, Jie Sheng, Shuang-Qin Yan, Wei-Jun Pan, Jia-Hu Hao, Peng Zhu, Fang-Biao Tao
OBJECTIVE: There is concern over the potential placental effects of prenatal phthalate exposure, and the potential adverse effects of prenatal phthalate exposure require further study; however, few data are available in humans. We investigated the associations between phthalate exposure in each trimester and both placental size and shape at birth. METHODS: We measured the urinary concentrations of phthalate metabolites among 2725 pregnant women in the Ma'anshan Birth Cohort...
October 10, 2017: Environmental Research
https://www.readbyqxmd.com/read/29028358/posterior-tibial-translation-measurements-on-magnetic-resonance-imaging-improve-diagnostic-sensitivity-for-chronic-posterior-cruciate-ligament-injuries-and-graft-tears
#9
Nicholas N DePhillipo, Mark E Cinque, Jonathan A Godin, Gilbert Moatshe, Jorge Chahla, Robert F LaPrade
BACKGROUND: Magnetic resonance imaging (MRI) of the knee is a highly sensitive and specific method for diagnosing acute posterior cruciate ligament (PCL) tears, with a reported accuracy of 96% to 100%. In chronic and revision settings, these injuries may be missed on MRI because of the apparent continuity of nonfunctional PCL fibers. Posterior tibial translation (PTT) of the medial compartment has been identified as a potential secondary finding of PCL tear on routine MRI. Purpose/Hypothesis: The purpose of this study was to evaluate the sensitivity of PTT on MRI associated with PCL injuries and compare it with the sensitivity of a radiologist's MRI interpretation with preoperative posterior knee stress radiographs as the gold standard...
October 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29028222/role-of-rbp2-induced-er-and-igf1r-erbb-signaling-in-tamoxifen-resistance-in-breast-cancer
#10
Hee-Joo Choi, Hyeong-Seok Joo, Hee-Young Won, Kyueng-Whan Min, Hyung-Yong Kim, Taekwon Son, Young-Ha Oh, Jeong-Yeon Lee, Gu Kong
Background: Despite the benefit of endocrine therapy, acquired resistance during or after treatment still remains a major challenge in estrogen receptor (ER)-positive breast cancer. We investigated the potential role of histone demethylase retinoblastoma-binding protein 2 (RBP2) in endocrine therapy resistance of breast cancer. Methods: Survival of breast cancer patients according to RBP2 expression was analyzed in three different breast cancer cohorts including METABRIC (n = 1980) and KM plotter (n = 1764)...
April 1, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29028092/long-non-coding-rna-ror-is-a-novel-prognosis-factor-associated-with-non-small-cell-lung-cancer-progression
#11
C-H Qu, Q-Y Sun, F-M Zhang, Y-M Jia
OBJECTIVE: The aim of the present study was to determine the expression levels of long intergenic non-protein coding RNA, regulator of reprogramming (linc-ROR) in non-small-cell lung cancer (NSCLC) patients and to further explore the prognostic value of this lncRNA. PATIENTS AND METHODS: In our investigation, we determined the expression of linc-ROR in human NSCLC tissues and matched normal lung tissues by quantitative Real-time-PCR analysis. Also, correlations between linc-ROR expression and the clinicopathological features were evaluated...
September 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29027893/hospital-acquired-conditions-predictors-and-implications-for-outcomes-following-spine-tumor-resection
#12
Nikita Lakomkin, Constantinos G Hadjipanayis
OBJECTIVE Hospital-acquired conditions (HACs) significantly compromise patient safety, and have been identified by the Centers for Medicare and Medicaid Services as events that will be associated with penalties for surgeons. The mitigation of HACs must be an important consideration during the postoperative management of patients undergoing spine tumor resection. The purpose of this study was to identify the risk factors for HACs and to characterize the relationship between HACs and other postoperative adverse events following spine tumor resection...
October 13, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29027862/effect-of-body-mass-index-on-outcome-after-aneurysmal-subarachnoid-hemorrhage-treated-with-clipping-versus-coiling
#13
Lorenzo Rinaldo, Joshua D Hughes, Alejandro A Rabinstein, Giuseppe Lanzino
OBJECTIVE It has been suggested that increased body mass index (BMI) may confer a protective effect on patients who suffer from aneurysmal subarachnoid hemorrhage (aSAH). Whether the modality of aneurysm occlusion influences the effect of BMI on patient outcomes is not well understood. The authors aimed to compare the effect of BMI on outcomes for patients with aSAH treated with surgical clipping versus endovascular coiling. METHODS The authors retrospectively reviewed the outcomes for patients admitted to their institution for the management of aSAH treated with either clipping or coiling...
October 13, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29027730/psychological-distress-in-post-partum-women-after-non-invasive-prenatal-testing-nipt-in-japan
#14
Eri Takeda, Nobuhiro Suzumori, Takeshi Ebara, Junko Yotsumoto, Kyoko Kumagai, Kumiko Oseto, Hironao Numabe, Mayumi Sugiura-Ogasawara
AIM: The purpose of this study was to clarify the characteristics of psychological mental distress in post-partum women after non-invasive prenatal testing (NIPT) in Japan. METHODS: Psychological mental distress was assessed using the Kessler Psychological Distress Scale (K6). We compared patients with (i) low pre-NIPT K6 and low post-partum K6 scores (control group), and (ii) low pre-NIPT K6 and a high post-partum K6 scores (case group). RESULTS: Among the 697 women who underwent NIPT, 29 (4...
October 13, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29027655/determinants-of-immediate-failure-of-noninvasive-mechanical-ventilation-outside-the-intensive-care-unit
#15
Killen H Briones Claudett, Monica H Briones Claudett, Antonio M Esquinas, Michelle Grunauer Andrade
BACKGROUND: This study aimed to characterize which are the early determinants of immediate failure of the use of noninvasive mechanical ventilation (NIMV) outside the ICU. METHODS: This prospective study included patients who were admitted to the Military Hospital in Guayaquil, Ecuador. Each variable was analyzed independently by using a multiple logistic regression model toward establishing an association with the event. A P-value of < 0.05 was considered statistically significant...
October 13, 2017: Anaesthesiology Intensive Therapy
https://www.readbyqxmd.com/read/29027608/ivabradine-in-postural-orthostatic-tachycardia-syndrome-preliminary-experience-in-children
#16
Grazia Delle Donne, Ferran Rosés Noguer, Jan Till, Tushar Salukhe, Sanjay K Prasad, Piers E F Daubeney
OBJECTIVE: Ivabradine is a selective and specific inhibitor of the I(f) current in the sinoatrial and atrioventricular nodes. It decreases heart rate and myocardial oxygen consumption at rest and during exercise. It is used in adults for management of heart failure and angina, but promising results have been obtained in postural orthostatic tachycardia syndrome (POTS). There is little experience of ivabradine in childhood, although it is used on a compassionate basis. Our aim was to review our experience of ivabradine in a retrospective evaluation of pediatric patients with POTS...
October 13, 2017: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
https://www.readbyqxmd.com/read/29027577/assessment-of-renal-perfusion-impairment-in-a-rat-model-of-acute-renal-congestion-using-contrast-enhanced-ultrasonography
#17
Kaoru Komuro, Yoshihiro Seo, Masayoshi Yamamoto, Seika Sai, Tomoko Ishizu, Kyo Shimazu, Yumi Takahashi, Shogo Imagawa, Teisuke Anzai, Kazuya Yonezawa, Kazutaka Aonuma
Renal congestion is caused by elevated central venous pressure (CVP), and decreases glomerular filtration in patients with congestive heart failure. Since real-time contrast-enhanced ultrasonography (CEUS) using microbubble-based contrast agents can visualize the perfused microvascular bed, we sought to evaluate the impairment of renal perfusion during acute renal congestion with CEUS. In Wister rats, CEUS of kidney was performed with the direct monitoring of CVP and intra-renal pressure (IRP). When CVP was elevated to 10 and 15 mmHg after the bolus injection of normal saline via the femoral vein, peak intensity (PI, dB) and time to PI (TTP) in the renal cortex and medulla were compared with control rats...
October 13, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/29027402/impact-of-vaginal-cylinder-diameter-on-outcomes-following-brachytherapy-for-early-stage-endometrial-cancer
#18
Jack M Qian, John M Stahl, Melissa R Young, Elena Ratner, Shari Damast
OBJECTIVE: To examine the outcomes (tolerability, toxicity, and recurrence) of vaginal brachytherapy (VBT) among endometrial cancer (EC) patients treated with small cylinder size. METHODS: Patients with EC who received adjuvant VBT between September 2011 and December 2015 were reviewed. Patients were fitted with the largest vaginal cylinder they could comfortably accommodate, from 2.0-3.0 cm diameter. Small cylinders were defined as size 2.3 cm or less. Patient, tumor, or treatment characteristics were correlated with need for small cylinders...
November 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/29027393/down-regulated-serum-microrna-101-is-associated-with-aggressive-progression-and-poor-prognosis-of-cervical-cancer
#19
Wei Jiang, Jia Jia Pan, Ying Hui Deng, Mei Rong Liang, Li Hua Yao
OBJECTIVE: MicroRNAs (miRNAs) play a vital role in pathogenesis and progression of many cancers, including cervical cancer. However, importance of serum level of miR-101 in cervical cancer has rarely been studied. In the present study, clinical significance and prognostic value of serum miR-101 for cervical cancer was investigated. METHODS: Association between miR-101 level in cervical cancer tissues and prognosis of patients was analyzed by using data retrieved from The Cancer Genome Atlas (TCGA) database, which was followed with our clinical study in which miR-101 serum level comparison between cervical cancer patients and healthy controls was conducted by real-time quantitative polymerase chain reaction (PCR)...
November 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/29027386/the-prevalence-and-risk-factors-of-renal-insufficiency-among-korean-hiv-infected-patients-the-korea-hiv-aids-cohort-study
#20
Eun Jin Kim, Jin Young Ahn, Youn Jeong Kim, Seong Heon Wie, Dae Won Park, Joon Young Song, Hee Jung Choi, Hyun Ha Chang, Bo Youl Choi, Yunsu Choi, Ju Yeon Choi, Myung Guk Han, Chun Kang, June Myung Kim, Jun Yong Choi
BACKGROUND: Renal disease is one of the leading causes of morbidity and mortality among people infected with human immunodeficiency virus (HIV). However, there are very few published studies about renal insufficiency in HIV-infected persons in Asia, especially in South Korea. MATERIALS AND METHODS: A cross-sectional study was performed to investigate the prevalence and risk factors of renal insufficiency, defined as <60 mL/min/1.73 m², in subjects in the Korea HIV/AIDS Cohort Study enrolled from 19 institutions between December 2006 and July 2013...
September 2017: Infection & Chemotherapy
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