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https://www.readbyqxmd.com/read/29916415/the-italian-national-external-quality-assessment-program-in-cytogenetics-4-years-of-activity-2013-2016-following-the-introduction-of-poor-performance-criteria
#1
Maria Chiara de Stefano, Giovanna Floridia, Federica Censi, Fabrizio Tosto, Marco Salvatore, Alessandro Civolani, Barbara Crescenzi, Daniela Giardino, Elisabetta Lenzini, Ermanna Lisi, Fortunato Lonardo, Marco Mancini, Antonio Novelli, Giuseppe Piombo, Sabine Stioui, Domenica Taruscio
BACKGROUND: Italian External Quality Assessment (IEQA) Program in Cytogenetics, established in 2001 by the Istituto Superiore di Sanità (ISS), covers both Constitutional and Oncohaematological diagnosis. In 2013, performance criteria were defined and adopted. In this paper, we present the data from the first 4 years of activity (2013-2016) following the introduction of performance criteria. METHODS: The enrollment is voluntary, fee-based and open to both public and private Italian laboratories...
April 2018: Annali Dell'Istituto Superiore di Sanità
https://www.readbyqxmd.com/read/29916412/knowledge-of-gestational-alcohol-drinking-risks-results-from-a-survey-among-italian-secondary-school-students
#2
Paolo Berretta, Adele Minutillo, Simona Pichini, Valeria Traverso, Giacomo Toth, Giulia Scaravelli, Roberto De Luca, Roberta Da Rin Della Mora
INTRODUCTION: Ethanol is the most widely used drug worldwide. Its consumption has been increasing, and it is reported even during childbearing. Prenatal exposure to ethanol can lead to irreversible damages of the fetus. Knowledge about this risk could prevent these damages. There is no information about knowledge of the Italian students on this issue. METHODS: Therefore the aim of this study was to describe the awareness of the Italian students attending the last year of secondary school about risk of gestational alcohol drinking for the delivering mother and the fetus...
April 2018: Annali Dell'Istituto Superiore di Sanità
https://www.readbyqxmd.com/read/29915761/the-ultrasound-identification-of-fetal-gender-at-the-gestational-age-of-11-12-weeks
#3
Farideh Gharekhanloo
Introduction: The early prenatal identification of fetal gender is of great importance. Accurate prenatal identification is currently only possible through invasive procedures. The present study was conducted to determine the accuracy and sensitivity of ultrasound fetal gender identification. Materials and Methods: The present cross-sectional study was conducted on 150 women in their 11th and 12th weeks of pregnancy in Hamadan in 2014. Ultrasound imaging performed in the 11th and 12th weeks of pregnancy for fetal gender identification identified the fetus either as a girl, a boy, or as a "gender not assigned...
January 2018: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29914900/tracheal-agenesis-in-a-new-born-lessons-learnt
#4
P Naina, Mary John, Mohamed Abdul Kathar, Manish Kumar
Tracheal agenesis is a rare but fatal congenital tracheal malformation. Lack of prenatal symptom and a typical clinical presentation lead to failure to arrive at a correct diagnosis and confusion during resuscitation. We report a case of a newborn male child with type 2 tracheal agenesis. Despite a typical presentation, diagnosis was delayed after unsuccessful intubation, examination under anaesthesia and emergency tracheostomy. The embryology, diagnostic criteria and potential treatment options are discussed...
June 17, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29914284/congenital-heart-defects-the-10-year-experience-at-a-single-center
#5
Emine Aydin, Ebru Aypar, Ahmet Oktem, Ozgur Ozyuncu, Murat Yurdakok, Murat Guvener, Metin Demircin, M Sinan Beksac
OBJECTIVE: We aimed to evaluate congenital heart disease (CHD) cases according to EUROCAT subgroup classification that were diagnosed during the prenatal period in our center. METHODS: CHDs that were prenatally diagnosed using ultrasonography and confirmed by fetal echocardiography were reviewed over a 10-year period. Subgroup classification was finalized at the post-partum period in terms of the EUROCAT guide 1.3. Congenital heart defect subtypes and obstetric outcomes (gestational week at delivery, birth weight, gender, extracardiac structural abnormalities, karyotype results if performed) were analyzed...
June 18, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29913238/the-sensitive-detection-of-ivsii-1-g%C3%AB-a-mutation-in-beta-globin-gene-using-a-nano-based-ligation-genotyping-system
#6
Somaye Heidari Sharafdarkolaee, Majid Motovali-Bashi, Pooria Gill
Beta-thalassemia (β-thalassemia) is a globally genetic diseases, and is most prevalent in the Middle East, particularly in Iran. Carrier detection and prenatal diagnosis are the best ways to managing it, and to prevent new community cases from emerging. We report on a simple method for rapid detection of the worst β-thalassemia point mutation in Iran (IVS-II-1 G>A), using a nano-based ligation assay, this was performed using probes with labeled magnetic nanoparticles and quantum dots. After optimizing the technique, 50 DNA samples were genotyped with this method...
June 15, 2018: Gene
https://www.readbyqxmd.com/read/29913228/effects-of-prenatal-exposure-to-cigarettes-on-anthropometrics-energy-intake-energy-expenditure-and-screen-time-in-children
#7
Jameason D Cameron, Éric Doucet, Kristi B Adamo, Mark Walker, Alessandro Tirelli, Joel D Barnes, Kaamel Hafizi, Marisa Murray, Gary S Goldfield
BACKGROUND: Maternal prenatal smoking is associated with downstream childhood obesity. Although animal research suggests reduced resting energy expenditure (REE), decreased physical activity (PA), and increased energy intake as mechanisms, these relationships are unclear in humans. The objectives were to examine the association of prenatal maternal smoking with non-volitional energy expenditure (REE and the thermic effect of feeding [TEF]), child adiposity, energy intake, free-living PA (daily light PA (LPA), daily moderate-to-vigorous PA (MVPA), daily sedentary behavior (SB)), and screen time (television and computer/video game) in children...
June 15, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29913173/diagnostic-accuracy-of-4-th-generation-architect-hiv-ag-ab-combo-assay-and-utility-of-signal-to-cutoff-ratio-to-predict-false-positive-hiv-tests-in-pregnancy
#8
Emily H Adhikari, Devin Macias, Donna Gaffney, Sarah White, Vanessa L Rogers, Donald D McIntire, Scott W Roberts
BACKGROUND: False positive HIV screening tests in pregnancy may lead to unnecessary interventions in labor. In 2014, the Centers for Disease Control and Prevention released a new algorithm for HIV diagnosis using a 4th generation screening test, which detects antibodies to HIV as well as p24 antigen and has a shorter window period compared with prior generations. A reactive screen requires a differentiation assay, and supplemental qualitative RNA testing is necessary for nonreactive differentiation assay...
June 15, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29913137/memantine-rescues-prenatal-citalopram-exposure-induced-striatal-and-social-abnormalities-in-mice
#9
Aqeela Zahra, Jinxiang Jiang, Yunan Chen, Cheng Long, Li Yang
Prenatal exposure to citalopram (CTM), an antidepressant drug, has been associated with altered behavior, including autism-like symptoms in both human and rodent offspring. However, the neurological basis underlying these abnormal behaviors is not well understood. Here, we examined behavioral, morphological, and biochemical alterations in the male and female offspring of C57BL/6 mouse mothers that had been exposed to CTM during the last trimester of gestation. We observed abnormal behavior such as anxiety, altered locomotion and disordered social interactions in 2-5 month old offspring with prenatal CTM exposure...
June 15, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29913015/comparison-of-safety-and-efficacy-of-methadone-vs-morphine-for-treatment-of-neonatal-abstinence-syndrome-a-randomized-clinical-trial
#10
Jonathan M Davis, Jeffrey Shenberger, Norma Terrin, Janis L Breeze, Mark Hudak, Elisha M Wachman, Peter Marro, Erica L Oliveira, Karen Harvey-Wilkes, Adam Czynski, Barbara Engelhardt, Karen D'Apolito, Debra Bogen, Barry Lester
Importance: Although opioids are used to treat neonatal abstinence syndrome (NAS), the best pharmacologic treatment has not been established. Objective: To compare the safety and efficacy of methadone and morphine in NAS. Design, Setting, and Participants: In this randomized, double-blind, intention-to-treat trial, term infants from 8 US newborn units whose mothers received buprenorphine, methadone, or opioids for pain control during pregnancy were eligible...
June 18, 2018: JAMA Pediatrics
https://www.readbyqxmd.com/read/29912954/impact-of-smartphone-assisted-prenatal-home-visits-on-women-s-use-of-facility-delivery-results-from-a-cluster-randomized-trial-in-rural-tanzania
#11
Kristy Hackett, Curtis Lafleur, Peter Nyella, Ophira Ginsburg, Wendy Lou, Daniel Sellen
BACKGROUND: About half of births in rural Tanzania are assisted by skilled providers. Point-of-care mobile phone applications hold promise in boosting job support for community health workers aiming to ensure safe motherhood through increased facility delivery awareness, access and uptake. We conducted a controlled comparison to evaluate a smartphone-based application designed to assist community health workers with data collection, education delivery, gestational danger sign identification, and referrals...
2018: PloS One
https://www.readbyqxmd.com/read/29912478/associations-between-state-level-policies-regarding-alcohol-use-among-pregnant-women-adverse-birth-outcomes-and-prenatal-care-utilization-results-from-1972-2013-vital-statistics
#12
Meenakshi S Subbaraman, Sue Thomas, Ryan Treffers, Kevin Delucchi, William C Kerr, Priscilla Martinez, Sarah C M Roberts
BACKGROUND: Policies regarding alcohol use during pregnancy continue to be enacted and debated in the United States. However, no study to date has examined whether these policies are related to birth outcomes, the outcomes they ultimately aim to improve. Here we assessed whether state-level policies targeting alcohol use during pregnancy are related to birth outcomes, which has not been done comprehensively before. METHODS: Secondary analyses of birth certificate data from N=148,048,208 United States singleton births between 1972-2013...
June 18, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29912347/prenatal-and-postnatal-exposure-to-persistent-organic-pollutants-pops-and-attention-deficit-and-hyperactivity-disorder-adhd-a-pooled-analysis-of-seven-european-birth-cohort-studies
#13
Joan Forns, Hein Stigum, Birgit Bjerre Høyer, Isabelle Sioen, Eva Sovcikova, Nikola Nowack, Maria-Jose Lopez-Espinosa, Mònica Guxens, Jesús Ibarluzea, Matias Torrent, Jürgen Wittsiepe, Eva Govarts, Tomas Trnovec, Cecile Chevrier, Gunnar Toft, Martine Vrijheid, Nina Iszatt, Merete Eggesbø
Background: Attention-deficit/hyperactivity disorder (ADHD) is increasing worldwide for reasons largely unknown and environmental chemicals with neurotoxic properties, such as persistent organic pollutants (POPs), have been proposed to play a role. We investigated the association between prenatal and postnatal exposure to polychlorinated biphenyl-153 (PCB-153), p-p´-dichlorodiphenyldichloroethylene (p-p'-DDE) and hexachlorobenzene (HCB) and ADHD in childhood. Methods: We pooled seven European birth cohort studies encompassing 4437 mother-child pairs from the general population with concentrations of PCB-153, p-p´-DDE and HCB measured in cord blood, maternal blood or milk...
April 17, 2018: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29911931/profile-of-roche-s-ariosa-harmony-prenatal-test
#14
Elisa Bevilacqua, Serena Resta, Andrew Carlin, Xin Kang, Teresa Cos Sanchez, Jérôme de Marchin, Jacques C Jani
Roche's Ariosa HarmonyTM Prenatal Test, a noninvasive cfDNA (cell-free DNA) method for major trisomies has been available since January-2013 at the authors unit and tests were sent to California. From July-2017 onwards, prenatal cfDNA has been reimbursed in Belgium for all pregnancies, however since then samples are sent to a local technology transfer center. Little data are available on patient's profile and choices towards cfDNA and on the performance of local technology transfer centers. Areas covered: The profiles and choices of women regarding this test were evaluated...
June 18, 2018: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/29911521/integrated-perinatal-mental-health-care-a-national-model-of-perinatal-primary-care-in-vulnerable-populations
#15
Kimberly C Lomonaco-Haycraft, Jennifer Hyer, Britney Tibbits, Jennifer Grote, Kelly Stainback-Tracy, Claire Ulrickson, Alison Lieberman, Lies van Bekkum, M Camille Hoffman
IntroductionPerinatal mood and anxiety disorders (PMADs) are the most common complication of pregnancy and have been found to have long-term implications for both mother and child. In vulnerable patient populations such as those served at Denver Health, a federally qualified health center the prevalence of PMADs is nearly double the nationally reported rate of 15-20%. Nearly 17% of women will be diagnosed with major depression at some point in their lives and those numbers are twice as high in women who live in poverty...
June 18, 2018: Primary Health Care Research & Development
https://www.readbyqxmd.com/read/29910801/lifelong-impacts-of-moderate-prenatal-alcohol-exposure-on-neuroimmune-function
#16
REVIEW
Shahani Noor, Erin D Milligan
In utero alcohol exposure is emerging as a major risk factor for lifelong aberrant neuroimmune function. Fetal alcohol spectrum disorder encompasses a range of behavioral and physiological sequelae that may occur throughout life and includes cognitive developmental disabilities as well as disease susceptibility related to aberrant immune and neuroimmune actions. Emerging data from clinical studies and findings from animal models support that very low to moderate levels of fetal alcohol exposure may reprogram the developing central nervous system leading to altered neuroimmune and neuroglial signaling during adulthood...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29910617/acetaminophen-antibiotics-ear-infection-breastfeeding-vitamin-d-drops-and-autism-an-epidemiological-study
#17
Seth Scott Bittker, Kathleen Roberta Bell
Background: While many studies have examined environmental risk factors for autism spectrum disorder (ASD), much of the research focus has been on prenatal or perinatal factors. Yet, the postnatal environment may affect the risk of ASD as well. Objective: To determine whether a set of five postnatal variables are associated with ASD. These variables are: acetaminophen exposure, antibiotic exposure, incidence of ear infection, decreased duration of breastfeeding, and decreased consumption of oral vitamin D drops...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29910115/effectiveness-of-prenatal-tetanus-diphtheria-acellular-pertussis-vaccination-in-the-prevention-of-infant-pertussis-in-the-u-s
#18
Sylvia Becker-Dreps, Anne M Butler, Leah J McGrath, Kim A Boggess, David J Weber, Dongmei Li, Michael G Hudgens, J Bradley Layton
INTRODUCTION: It is recommended that all pregnant women in the U.S. receive tetanus, diphtheria, acellular pertussis (Tdap) immunization to prevent infant pertussis. This study's objective was to examine the clinical effectiveness of prenatal Tdap, and whether effectiveness varies by gestational age at immunization. METHODS: A nationwide cohort study of pregnant women with deliveries in 2010-2014 and their infants was performed. Commercial insurance claims data were analyzed in 2016-2017 to identify Tdap receipt by the pregnant women, and hospitalizations and outpatient visits for pertussis in their infants until the infants reached 18 months of age...
June 11, 2018: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29909595/disability-experiences-and-perspectives-regarding-reproductive-decisions-parenting-and-the-utility-of-genetic-services-a-qualitative-study
#19
C Roadhouse, C Shuman, K Anstey, K Sappleton, D Chitayat, E Ignagni
Genetic counselors adopt seemingly contradictory roles: advocating for individuals with genetic conditions while offering prenatal diagnosis and the option of selective termination to prevent the birth of a child with a disability. This duality contributes to the tension between the disability and clinical genetics communities. Varying opinions exist amongst the disability community: some value genetic services while others are opposed. However, there is limited research exploring the opinions of individuals with a disability regarding issues related to reproduction and genetic services in the context of personal experience...
June 16, 2018: Journal of Genetic Counseling
https://www.readbyqxmd.com/read/29909441/annular-pancreas-in-china-9-years-experience-from-a-single-center
#20
REVIEW
DengLiang Wang, Quan Kang, ShuJun Shi, Wei Hu
To summarize the clinical characteristics, diagnosis, treatment and prognosis among 152 children with annular pancreas (AP). A retrospective review of 152 patients with AP who were treated with surgical repair between January 2009 and August 2017 was performed at our pediatric surgical units. Presenting symptoms, birth weight, radiological findings, associated anomalies, the type of surgery performed were analyzed. (1) 152 patients were identified, out of which 82 were males, and 70 were females; (2) the average birth weight of children with AP was less than that of healthy newborns...
June 16, 2018: Pediatric Surgery International
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