keyword
https://read.qxmd.com/read/38536856/factors-associated-with-the-uptake-of-intermittent-preventive-treatment-for-malaria-during-pregnancy-in-cameroon-an-analysis-of-data-from-the-2018-cameroon-demographic-and-health-survey
#1
JOURNAL ARTICLE
Dominique Ken Guimsop, Ange Faustine Kenmogne Talla, Haoua Kodji, Jerome Ateudjieu
Malaria in pregnancy is a major public health concern that contributes to a significant increase in maternal and child mortality and morbidity. Intermittent preventive treatment of malaria during pregnancy using sulfadoxine-pyrimethamine (IPTp-SP) is a key intervention recommended by the World Health Organization (WHO) and implemented in Cameroon to reduce the morbidity associated with malaria during pregnancy. This study aimed to assess the distribution of the poor uptake of IPTp-SP (i.e. fewer than three doses) in Cameroon and the factors associated...
2024: PLOS Glob Public Health
https://read.qxmd.com/read/38536215/infant-mortality-by-selected-maternal-characteristics-and-race-and-hispanic-origin-in-the-united-states-2019-2021
#2
JOURNAL ARTICLE
Danielle M Ely, Anne K Driscoll
Objectives- This report presents infant mortality rates for selected maternal characteristics (prepregnancy body mass index, cigarette smoking during pregnancy, receipt of Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) benefits during pregnancy, timing of prenatal care, and source of payment for delivery) for the five largest maternal race and Hispanic-origin groups in the United States for combined years 2019-2021. Methods-Descriptive tabulations based on data from the linked birth/infant death files for 2019-2021 are presented...
March 2024: National Vital Statistics Reports
https://read.qxmd.com/read/38535543/prenatal-maternal-immunization-for-infant-protection-a-review-of-the-vaccines-recommended-infant-immunity-and-future-research-directions
#3
REVIEW
Elizabeth M Quincer, Lisa M Cranmer, Satoshi Kamidani
Prenatal maternal immunization is an effective tool to protect mothers and infants from poor health outcomes due to infectious diseases. We provide an overview of the rationale for the use of prenatal vaccines, discuss the immunologic environment of the maternal-fetal interface including the impact of maternal vaccines prenatally and subsequently on the infant's immune response, and review vaccines currently recommended in pregnancy and landscape for the future of maternal vaccination. This review aims to provide an understanding of the recent history and progress made in the field and highlight the importance of continued research and development into new vaccines for pregnant populations...
February 23, 2024: Pathogens
https://read.qxmd.com/read/38534344/intrauterine-growth-restriction-need-to-improve-diagnostic-accuracy-and-evidence-for-a-key-role-of-oxidative-stress-in-neonatal-and-long-term-sequelae
#4
REVIEW
Eva Nüsken, Sarah Appel, Leon Saschin, Celien Kuiper-Makris, Laura Oberholz, Charlotte Schömig, Anne Tauscher, Jörg Dötsch, Angela Kribs, Miguel A Alejandre Alcazar, Kai-Dietrich Nüsken
Intrauterine growth restriction (IUGR) and being small for gestational age (SGA) are two distinct conditions with different implications for short- and long-term child development. SGA is present if the estimated fetal or birth weight is below the tenth percentile. IUGR can be identified by additional abnormalities (pathological Doppler sonography, oligohydramnion, lack of growth in the interval, estimated weight below the third percentile) and can also be present in fetuses and neonates with weights above the tenth percentile...
March 13, 2024: Cells
https://read.qxmd.com/read/38533951/impact-of-an-impaired-maternal-fetal-environment-on-death-in-children-with-congenital-heart-defects-undergoing-surgery-in-denmark-from-1994-to-2018
#5
JOURNAL ARTICLE
Rasmus Kristensen, Camilla Omann, Charlotte K Ekelund, J William Gaynor, Vibeke E Hjortdal
BACKGROUND: Studies show that an impaired maternal-fetal environment (iMFE) increases the mortality risk in children with single-ventricle congenital heart defects (CHDs). We investigated the impact of an iMFE on death in children with various surgically corrected CHDs. METHODS AND RESULTS: In this nationwide register-based study, we examined the association between an iMFE (including preeclampsia, gestational hypertension, gestational diabetes, maternal smoking during pregnancy) and death in a large cohort of children with surgically corrected CHDs in Denmark (1994-2018)...
March 27, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38533642/increased-risk-of-gestational-hypertension-by-periconceptional-exposure-to-ambient-air-pollution-and-effect-modification-by-prenatal-depression
#6
JOURNAL ARTICLE
Zhongzheng Niu, Rima Habre, Tingyu Yang, Xinci Chen, Mario Vigil, Karina Barragan, Fred Lurmann, Nathan R Pavlovic, Brendan H Grubbs, Claudia M Toledo-Corral, Jill Johnston, Genevieve F Dunton, Deborah Lerner, Nathana Lurvey, Laila Al-Marayati, Sandrah P Eckel, Carrie V Breton, Theresa M Bastain, Shohreh F Farzan
BACKGROUND: Air pollution has been associated with gestational hypertension (GH) and preeclampsia, but susceptible windows of exposure and potential vulnerability by comorbidities, such as prenatal depression, remain unclear. METHODS: We ascertained GH and preeclampsia cases in a prospective pregnancy cohort in Los Angeles, CA. Daily levels of ambient particles (with a diameter of ≤10 μm [PM10 ] or ≤2.5 μm [PM2.5 ]), nitrogen dioxide, and ozone were averaged for each week from 12 weeks preconception to 20 gestational weeks...
March 27, 2024: Hypertension
https://read.qxmd.com/read/38533521/embryo-and-fetal-gene-editing-technical-challenges-and-progress-toward-clinical-applications
#7
REVIEW
Citra N Z Mattar, Wei Leong Chew, Poh San Lai
Gene modification therapies (GMTs) are slowly but steadily making progress toward clinical application. As the majority of rare diseases have an identified genetic cause, and as rare diseases collectively affect 5% of the global population, it is increasingly important to devise gene correction strategies to address the root causes of the most devastating of these diseases and to provide access to these novel therapies to the most affected populations. The main barriers to providing greater access to GMTs continue to be the prohibitive cost of developing these novel drugs at clinically relevant doses, subtherapeutic effects, and toxicity related to the specific agents or high doses required...
June 13, 2024: Molecular Therapy. Methods & Clinical Development
https://read.qxmd.com/read/38533444/small-size-big-problems-insights-and-difficulties-in-prenatal-diagnosis-of-fetal-microcephaly
#8
REVIEW
Leila Haddad, Efrat Hadi, Zvi Leibovitz, Dorit Lev, Yoseph Shalev, Liat Gindes, Tally Lerman-Sagie
Microcephaly is a sign, not a diagnosis. Its incidence varies widely due to the differences in the definition and the population being studied. It is strongly related to neurodevelopmental disorders. Differences in definitions and measurement techniques between fetuses and newborns pose a great challenge for the diagnosis and prognostication of fetal microcephaly. A false positive diagnosis can result (in countries where it is legal) in erroneous termination of pregnancy, where a false negative diagnosis might lead to the birth of a microcephalic newborn...
2024: Frontiers in Neuroscience
https://read.qxmd.com/read/38532648/unraveling-hypothalamus-pituitary-dysregulation-hypergonadotropism-in-f-1-progeny-due-to-prenatal-exposure-to-hexavalent-chromium
#9
JOURNAL ARTICLE
Ajit Kumar Navin, Mariajoseph Michael Aruldhas, Kathiresh Kumar Mani, Shobana Navaneethabalakrishnan, Sankar Venkatachalam, Sakhila K Banu
The endocrine disruptor hexavalent chromium [Cr(VI)] is a proven reproductive toxicant. We recently demonstrated that prenatal Cr(VI) exposure causes testicular resistance to gonadotropins, resulting in hypergonadotropic hypoandrogenism in F1 rats. However, the mechanism driving hypergonadotropism in F1 rats exposed to Cr(VI) prenatally remains an enigma. Therefore, we hypothesized that 'Prenatal Cr(VI) exposure may disrupt steroid hormones-mediated negative feedback regulation of the hypothalamic GnRH, and its receptor in the pituitary of F1 rats, leading to hypergonadotropism...
April 2024: Journal of Biochemical and Molecular Toxicology
https://read.qxmd.com/read/38532440/anatomical-and-functional-changes-of-the-fetal-adrenal-gland-in-intrauterine-growth-restriction
#10
JOURNAL ARTICLE
Serena Martinelli, Alessandro Rolfo, Carlotta Pace, Letizia Canu, Anna Maria Nuzzo, Domenica Giuffrida, Pietro Gaglioti, Tullia Todros
OBJECTIVE: The aim of this study was to demonstrate the establishment of adrenal sparing in intrauterine growth restricted (IUGR) human fetuses. IUGR fetuses are a subgroup of small for gestational age (SGA) fetuses that are unable to reach their own growth potential because of chronic hypoxia and undernutrition. We hypothesized that in IUGR fetuses the adrenal gland is relatively larger and secretion of noradrenaline (NA), adrenaline (A), and cortisol is increased. STUDY DESIGN: This is a prospective observational study including 65 singleton pregnancies (42 IUGR and 23 controls)...
March 26, 2024: International Journal of Gynaecology and Obstetrics
https://read.qxmd.com/read/38532382/depression-during-pregnancy-and-associated-factors-among-women-in-ethiopia-a-systematic-review-and-meta-analysis
#11
JOURNAL ARTICLE
Solomon Shitu Ayen, Abebaw Wasie Kasahun, Amare Zewdie
BACKGROUND: Pregnancy is one of the most remarkable experiences in a woman's life. Prenatal depression, characterized by stress and worry associated with pregnancy, can reach severe levels. On a global scale, mental and addictive disorders affect more than one billion people, causing 19% of years lived with disability. It is estimated that 25-35% of pregnant women experience depressive symptoms, with 20% meeting the diagnostic criteria for major depression. METHODS: A systematic review and meta-analysis were conducted to examine depression during pregnancy in Ethiopia...
March 26, 2024: BMC Pregnancy and Childbirth
https://read.qxmd.com/read/38532175/overview-of-the-indigenous-health-of-the-yanomami-ethnic-group-in-brazil-a-public-health-emergency
#12
JOURNAL ARTICLE
Nathália Mariana Santos Sansone, Eduarda Vitta, Bianca Aparecida Siqueira, Fernando Augusto Lima Marson
INTRODUCTION: The Indigenous population of the Yanomami ethnic group in Brazil is currently facing a public health emergency due to the high number of deaths, mainly of children. Taking that into consideration, this study aims to analyze this crisis impact on the health of this population in the period between 2018 and 2022. METHODS: The data presented were collected from the report called Yanomami Mission ("Missão Yanomami") published by the Brazilian Ministry of Health and, from it, a descriptive analysis of the Indigenous individuals' health was carried out for (i) the geographical distribution; ii) the number of deaths; (iii) the child death rate; (iv) the deaths of Indigenous individuals from preventable causes; (v) the causes of preventable diseases related to hygiene and basic sanitation, and the distribution of diarrheal diseases according to age groups; (vi) evaluation of the nutritional classification; vii) the percentage (%) of the complete vaccination scheme, and (viii) the coverage of prenatal appointments of Indigenous pregnant women...
March 26, 2024: Journal of Racial and Ethnic Health Disparities
https://read.qxmd.com/read/38532124/the-joint-effects-of-prenatal-exposure-to-pm-2-5-constituents-and-reduced-fetal-growth-on-children-s-accelerated-growth-in-the-first-3-years-a-birth-cohort-study
#13
JOURNAL ARTICLE
Shuang Zhou, Tiantian Li, Na Han, Kai Zhang, Gongbo Chen, Yi Zhang, Qin Li, Yuelong Ji, Jue Liu, Hui Wang, Jianlin Hu, Ting Liu, Hein Raat, Yuming Guo, Haijun Wang
BACKGROUND: Prenatal fine particulate matter (PM2.5 ) constituents exposure and reduced fetal growth may be risk factors for accelerated growth in early childhood, an important indicator for lifelong health. OBJECTIVE: The study investigated whether the joint effects are present between PM2.5 constituents and reduced fetal growth. METHODS: The study was embedded in a birth cohort in China, including 5424 mother-child pairs. Prenatal PM2.5 and its constituents' [organic carbon (OC), elementary carbon (EC), ammonium (NH4 + ), nitrate (NO3 - ), and sulfate (SO4 2- )] concentrations were estimated based on maternal residential addresses...
March 26, 2024: Journal of Exposure Science & Environmental Epidemiology
https://read.qxmd.com/read/38531894/abundant-pleiotropy-across-neuroimaging-modalities-identified-through-a-multivariate-genome-wide-association-study
#14
JOURNAL ARTICLE
E P Tissink, A A Shadrin, D van der Meer, N Parker, G Hindley, D Roelfs, O Frei, C C Fan, M Nagel, T Nærland, M Budisteanu, S Djurovic, L T Westlye, M P van den Heuvel, D Posthuma, T Kaufmann, A M Dale, O A Andreassen
Genetic pleiotropy is abundant across spatially distributed brain characteristics derived from one neuroimaging modality (e.g. structural, functional or diffusion magnetic resonance imaging [MRI]). A better understanding of pleiotropy across modalities could inform us on the integration of brain function, micro- and macrostructure. Here we show extensive genetic overlap across neuroimaging modalities at a locus and gene level in the UK Biobank (N = 34,029) and ABCD Study (N = 8607)...
March 26, 2024: Nature Communications
https://read.qxmd.com/read/38531728/reduced-pertussis-disease-severity-in-infants-following-the-introduction-of-pertussis-vaccination-of-pregnant-women-in-spain-2015-2019
#15
JOURNAL ARTICLE
Andrea Parisi, Olivier Nuñez, Noemí López-Perea, Josefa Masa-Calles
BACKGROUND: Maternal pertussis vaccination during the third trimester of pregnancy was implemented in 2015 in Spain, reaching a national coverage of 84% in 2019. In this ecological study, we investigated whether there was a change in the disease severity for pertussis in infants upon introduction of prenatal pertussis vaccination. METHODS: We performed a time-trend analysis of infant pertussis hospitalizations during 2005-2019 in Spain using national register data...
March 25, 2024: Vaccine
https://read.qxmd.com/read/38531505/residential-greenness-during-pregnancy-and-early-life-and-development-of-asthma-up-to-27-years-of-age-the-espoo-cohort-study
#16
JOURNAL ARTICLE
Aino K Rantala, Inês Paciência, Harri Antikainen, Jan Hjort, Timo T Hugg, Maritta S Jaakkola, Jouni J K Jaakkola
Previous studies have suggested that living close to green spaces has protective health effects, but potential effects on asthma are contradictory. We investigated the association between the amount of greenness in the residential area during pregnancy and early life and development of asthma in the first 27 years of life. The study population included all 2568 members of the Espoo Cohort Study, Finland. We calculated individual-level exposure to green space measured as cumulative Normalized Difference Vegetation Index (cumNDVI in unit-months) within 300 m of the participant's residence during pregnancy and the first two years of life in both spring and summer seasons...
March 24, 2024: Environmental Research
https://read.qxmd.com/read/38531391/increased-rates-of-hypertensive-disorders-of-pregnancy-during-the-covid-19-pandemic
#17
JOURNAL ARTICLE
Colleen Sinnott, Taylor S Freret, Mark A Clapp, Sarah E Little
OBJECTIVE: Hypertensive disorders of pregnancy (HDP) are common complications associated with severe maternal and neonatal morbidity. One goal of prenatal care, especially at term, is to screen for HDP. As treatment of HDP centers on delivery when appropriate, timely diagnosis is crucial. We postulated that reduced in-person visits during the COVID-19 pandemic may have resulted in delayed diagnosis of HDP with concomitant higher rates of maternal morbidity. We sought to investigate the prevalence of HDP during the COVID-19 pandemic, as well as median gestational age at time of delivery as compared to the pre-pandemic median...
March 26, 2024: American Journal of Perinatology
https://read.qxmd.com/read/38531180/evaluation-of-elastic-venous-compression-device-dispensation-in-pregnant-and-post-partum-women-using-the-french-national-health-insurance-claims-database-the-profil-retrospective-cohort-study
#18
JOURNAL ARTICLE
Olivier Joassard, Anne-Laure Kerveillant, Claire Sellal, Erwana Coatantiec, Violaine Jabbour, Guillaume Desjeux, Ben Braithwaite, Antoine Elias, Arnaud Fauconnier
OBJECTIVES: To describe the real-world use of Elastic Venous Compression Devices (EVCDs) during pregnancy and post-partum using data from a representative subset of the French National Health Insurance Claims Database (the Echantillon Généraliste des Bénéficiaires, EGB). STUDY DESIGN: Women aged 15-49 who were pregnant between 1st July 2017 and 15th June 2018 were identified in the EGB using pregnancy-specific acts (certain prenatal examinations or deliveries)...
March 15, 2024: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://read.qxmd.com/read/38531021/neurodevelopmental-and-functional-outcomes-following-in-utero-exposure-to-antiseizure-medication-a-systematic-review
#19
JOURNAL ARTICLE
Eliza Honybun, Emily Cockle, Charles B Malpas, Terence J O'Brien, Frank J Vajda, Piero Perucca, Genevieve Rayner
BACKGROUND AND OBJECTIVES: To undertake a systematic review of the available literature to examine the relationship between prenatal antiseizure medication (ASM) exposure and adverse postnatal neurodevelopmental outcomes, focusing on social, emotional, behavioral, and adaptive domains of human function, and the frequency of neurodevelopmental and psychiatric disorders in ASM-exposed offspring. METHODS: Electronic searches of MEDLINE, PsychINFO, and EMBASE were conducted and limited to studies published between 1990 and 2023 in English...
April 23, 2024: Neurology
https://read.qxmd.com/read/38530807/variables-included-in-cerebral-palsy-registries-globally-a-scoping-review
#20
REVIEW
Thembi J Katangwe, Mariana Kruger, Takondwa Chimowa, Innocent Maposa, Ronald Van Toorn, Regan Solomons, Kirsten A Donald
AIM: To identify cerebral palsy (CP) variables collected in CP registries from high-income countries (HICs) and low- and middle-income countries (LMICs) to assist with the development of a regional CP registry relevant to the African region. METHOD: A systematic search of online databases to identify peer-reviewed publications and grey literature about CP risk-factor variables, using Ovid MEDLINE, Embase Ovid, CINAHL, and Google Scholar. RESULTS: A total of 197 studies published from global CP registries between 1990 and 2023 were identified...
March 26, 2024: Developmental Medicine and Child Neurology
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