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https://www.readbyqxmd.com/read/29166711/-effects-of-caspase-1-inhibitor-vx765-on-cold-restraint-stress-induced-acute-gastric-ulcer-in-mice
#1
S Q Zheng, X D Hong, T S Chen, P F Luo, S C Xiao
Objective: To investigate the protective effects of caspase-1 inhibitor VX765 on gastric mucosa of mice with cold-restraint stress-induced acute gastric ulcer. Methods: Twenty-four specific pathogen free male C57BL/6J mice were divided into normal control group (NC), cold restrain group (CR), VX765 pre-treatment+ cold restrain group (VCR), and rabeprazole pre-treatment+ cold restrain group (RCR) according to the random number table, with 6 mice in each group. Mice in group NC were injected intraperitoneally with solution of 10 mL/kg dimethylsulfoxide (DMSO) and phosphate buffer solution (PBS)...
November 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/29166710/-effects-of-hydrogen-on-the-lung-damage-of-mice-at-early-stage-of-severe-burn
#2
C Qin, Y X Bian, T T Feng, J H Zhang, Y H Yu
Objective: To investigate the effects of hydrogen on the lung damage of mice at early stage of severe burn. Methods: One hundred and sixty ICR mice were divided into sham injury, hydrogen, pure burn, and burn+ hydrogen groups according to the random number table, with 40 mice in each group. Mice in pure burn group and burn+ hydrogen group were inflicted with 40% total body surface area full-thickness scald (hereafter referred to as burn) on the back, while mice in sham injury group and hydrogen group were sham injured...
November 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/29166391/early-kinetics-of-serum-interleukine-17a-and-infarct-size-in-patients-with-reperfused-acute-st-elevated-myocardial-infarction
#3
Thomas Bochaton, Nathan Mewton, NDieme Thiam, Fabien Lavocat, Delphine Baetz, Nathalie Dufay, Cyril Prieur, Eric Bonnefoy-Cudraz, Pierre Miossec, Michel Ovize
BACKGROUND: Recently, it was shown that interleukin-17A (IL-17A) is involved in the pathophysiology of reperfusion injury and associated with infarct size (IS) in experimental models of myocardial infarction. Our aim was to evaluate whether the IL-17A serum level and the IL-17A active fraction was correlated with IS in humans. METHODS: 101 patients presenting with a ST-elevated Myocardial Infarction (STEMI) referred for primary percutaneous coronary intervention (PPCI) and 10 healthy controls were included...
2017: PloS One
https://www.readbyqxmd.com/read/29166379/bcfa-enriched-vernix-monoacylglycerol-reduces-lps-induced-inflammatory-markers-in-human-enterocytes-in-vitro
#4
Yuanyuan Yan, Zhen Wang, Donghao Wang, Peter Lawrence, Xingguo Wang, Kumar S D Kothapalli, Jacelyn Greenwald, Ruijie Liu, Hui Gyu Park, J Thomas Brenna
BACKGROUND: Excess vernix caseosa produced by the fetal skin appears as particles suspended in the amniotic fluid in late gestation, is swallowed by the fetus and is found throughout the newborn GI tract as the first organisms are arriving to colonize the gut. Lipid rich vernix contains an unusually high 29% branched chain fatty acid (BCFA). BCFA reduce the incidence of necrotizing enterocolitis in an animal model, recently found predominantly in the sn-2 position of human milk triacylglycerols...
November 22, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29165819/metastasectomy-following-incomplete-response-to-high-dose-interleukin-2
#5
Tasha Hughes, Joseph Broucek, Gail Iodice, Praveen K Bommareddy, Sanjib Basu, Howard L Kaufman
OBJECTIVE: To evaluate our experience with metastasectomy following partial response or stable disease after treatment with high-dose interleukin-2 (HD IL-2). METHODS: A total of 305 patients with metastatic renal cell carcinoma or melanoma treated with HD IL-2 over a 12-year period were reviewed. Age, objective response, and overall survival data were evaluated using standard RECIST criteria and Kaplan-Meier estimates. RESULTS: The average age was 55...
November 22, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29164996/cptp-a-sphingolipid-transfer-protein-that-regulates-autophagy-and-inflammasome-activation
#6
Shrawan Kumar Mishra, Yong-Guang Gao, Yibin Deng, Charles E Chalfant, Edward H Hinchcliffe, Rhoderick E Brown
The macroautophagy/autophagy and inflammasome pathways are linked through their roles in innate immunity and chronic inflammatory disease. Ceramide-1-phosphate (C1P) is a bioactive sphingolipid that regulates pro-inflammatory eicosanoid production. Whether C1P also regulates autophagy and inflammasome assembly/activation is not known. Here we show that CPTP (a protein that traffics C1P from its site of phosphorylation in the trans-Golgi to target membranes) regulates both autophagy and inflammasome activation...
November 22, 2017: Autophagy
https://www.readbyqxmd.com/read/29164679/novel-antioxidant-and-anti-inflammatory-peptides-from-the-siamese-crocodile-crocodylus-siamensis-hemoglobin-hydrolysate
#7
Jiraporn Lueangsakulthai, Santi Phosri, Tinnakorn Theansungnoen, Nisachon Jangpromma, Theeranan Temsiripong, John E Mckendrick, Watcharee Khunkitti, Sompong Klaynongsruang
Novel antioxidant and anti-inflammatory peptides were isolated from hydrolysates of Siamese crocodile (Crocodylus siamensis) hemoglobin. Crocodylus siamensis hemoglobin hydrolysates (CHHs) were obtained by pepsin digestion at different incubation times (2, 4, 6 and 8 H) at 37 °C and subjected to antioxidant and anti-inflammatory activity assessment. CHH obtained by 2-H hydrolysis (2H-CHH) showed the highest anti-inflammatory activity with respect to decreasing nitric oxide (NO) production, while the strongest antioxidant activity was found for 6-H hydrolysis (6H-CHH) against nitric oxide radicals...
November 22, 2017: Biotechnology and Applied Biochemistry
https://www.readbyqxmd.com/read/29164060/tissue-factor-expressing-tumor-derived-extracellular-vesicles-activate-quiescent-endothelial-cells-via-protease-activated-receptor-1
#8
Sara P Y Che, Jeannie Y Park, Tracy Stokol
Tissue factor (TF)-expressing tumor-derived extracellular vesicles (EVs) can promote metastasis and pre-metastatic niche formation, but the mechanisms by which this occurs remain largely unknown. We hypothesized that generation of activated factor X (FXa) by TF expressed on tumor-derived EV could activate protease-activated receptors (PARs) on non-activated endothelial cells to induce a pro-adhesive and pro-inflammatory phenotype. We obtained EV from TF-expressing breast (MDA-MB-231) and pancreatic (BxPC3 and Capan-1) tumor cell lines...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/29163679/identification-of-molecular-mechanisms-of-glutamine-in-pancreatic-cancer
#9
Zhen-Yi Jia, Tong-Yi Shen, Wei Jiang, Huan-Long Qin
The aim of the present study was to explore the critical genes and molecular mechanisms in pancreatic cancer (PC) cells with glutamine. By analyzing microarray data GSE17632 from the Gene Expression Omnibus database, the DEGs between PC cells treated with glutamine and without glutamine were evaluated. Additionally, function enrichment analyses and protein-protein interaction (PPI) network construction of DEGs were performed. Network module and literature mining analyses were performed to analyze the critical DEGs in PC cells...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29163429/relationship-between-gingival-crevicular-fluid-microbiota-and-cytokine-profile-in-periodontal-host-homeostasis
#10
Jianye Zhou, Yiqing Yao, Kangli Jiao, Jumei Zhang, Xin Zheng, Fang Wu, Xiaopan Hu, Junping Li, Zhanhai Yu, Gaosen Zhang, Nan Jiang, Zhiqiang Li
As potential biomarkers in periodontitis, microbiome, and cytokines have recently been extensively investigated, but combined analyses of the variations between the microbial structure and cytokine composition are rare. The present study aimed to investigate whether there are differences in the combined profile of microbiome and cytokines in individuals with or without periodontitis. The microbiome and cytokine composition in gingival crevicular fluid (GCF) from 16 patients and 15 controls from Jishi Shan (Gansu, China) were analyzed using 454 pyrosequencing and RayBio Quantibody Arrays...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29162766/production-and-rearing-of-germ-free-x-scid-pigs
#11
Hiromasa Hara, Hiroaki Shibata, Kazuaki Nakano, Tomoyuki Abe, Hideki Uosaki, Takahiro Ohnuki, Shuji Hishikawa, Satoshi Kunita, Masahito Watanabe, Osamu Nureki, Hiroshi Nagashima, Yutaka Hanazono
Pigs with X-linked severe combined immunodeficiency (X-SCID) caused by a mutation of the interleukin-2 receptor gamma chain gene (IL2RG) are of value for a wide range of studies. However, they do not survive longer than 8 weeks because of their susceptibility to infections. To allow longer survival of X-SCID pigs, the animals must be born and reared under germ-free conditions. Here, we established an efficient system for piglet derivation by hysterectomy and used it to obtain and maintain a germ-free X-SCID pig...
November 21, 2017: Experimental Animals
https://www.readbyqxmd.com/read/29162603/exogenous-insulin-infusion-can-decrease-atherosclerosis-in-diabetic-rodents-by-improving-lipids-inflammation-and-endothelial-function
#12
Kyoungmin Park, Qian Li, Net Daş Evcimen, Christian Rask-Madsen, Yasutaka Maeda, Ernesto Maddaloni, Hisashi Yokomizo, Takanori Shinjo, Ronald St-Louis, Jialin Fu, Daniel Gordin, Mogher Khamaisi, David Pober, Hillary Keenan, George L King
OBJECTIVE: The objective of this study is to evaluate whether exogenously induced hyperinsulinemia may increase the development of atherosclerosis. APPROACH AND RESULTS: Hyperinsulinemia, induced by exogenous insulin implantation in high-fat fed (60% fat HFD) apolipoprotein E-deficient mice (ApoE(-/-)) mice, exhibited insulin resistance, hyperglycemia, and hyperinsulinemia. Atherosclerosis was measured by the accumulation of fat, macrophage, and extracellular matrix in the aorta...
November 21, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29162160/high-urinary-interleukin-2-in-late-post-transplant-period-portends-a-risk-of-decline-in-kidney-allograft-function-a-preliminary-study
#13
Andriy V Trailin, Marina V Pleten, Tetyana I Ostapenko, Nadiia F Iefimenko, Olexandr S Nykonenko
BACKGROUND: Predictive factors for the rate of decline in kidney allograft function beyond the first post-transplant year have not been thoroughly studied. We aimed to determine whether a single measurement of serum and urinary interleukin 2, interleukin 8 and interleukin 10 at 1-15 years after kidney transplantation could predict a decline in estimated glomerular filtration rate (eGFR) over a 2-year period. RESULTS: Greater serum concentrations of interleukin 8 and interleukin 10 in 30 recipients of kidney allograft at enrollment were associated with lower eGFR after 1 year (beta = - 0...
November 21, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29160881/effect-of-nobiletin-on-the-mapk-nf-%C3%AE%C2%BAb-signaling-pathway-in-the-synovial-membrane-of-rats-with-arthritis-induced-by-collagen
#14
Guliang Yang, Shiming Li, Li Yuan, Yiwen Yang, Min-Hsiung Pan
Nobiletin (5,6,7,8,3',4'-hexamethoxyflavone) is a natural compound in the fruit peel of citrus fruit in the Rutaceae family. It is active in inhibiting inflammation, reducing plasma lipids and has anti-oxidative properties. In studying the effect of nobiletin on rheumatoid arthritis (RA), the collagen-induced arthritis (CIA) model on Sprague-Dawley (SD) rats was established by bovine type II collagen (BIIC), and the effect of nobiletin on RA was investigated using hematoxylin-eosin (H&E) staining, serum enzyme linked immunosorbent assay (ELISA) detection and western blotting...
November 21, 2017: Food & Function
https://www.readbyqxmd.com/read/29160425/local-and-systemic-effects-of-fibrin-and-cyanoacrylate-adhesives-on-lung-lesions-in-rabbits
#15
Marcus V H Carvalho, Evaldo Marchi, Andre J Fruchi, Bruno V B Dias, Clovis L Pinto, Geovane R Dos Santos, Milena M P Acencio
OBJECTIVES: Tissue adhesives can be used to prevent pulmonary air leaks, which frequently occur after lung interventions. The objective of this study is to evaluate local and systemic effects of fibrin and cyanoacrylate tissue adhesives on lung lesions in rabbits. METHODS: Eighteen rabbits were submitted to videothoracoscopy + lung incision alone (control) or videothoracoscopy + lung incision + local application of fibrin or cyanoacrylate adhesive. Blood samples were collected and assessed for leukocyte, neutrophil and lymphocyte counts and interleukin-8 levels preoperatively and at 48 hours and 28 days post-operatively...
October 2017: Clinics
https://www.readbyqxmd.com/read/29159589/the-effect-of-mindfulness-based-stress-reduction-on-wound-healing-a-preliminary-study
#16
Astrid Meesters, Yvo M C In den Bosch-Meevissen, Chantal A H Weijzen, Wim A Buurman, Mario Losen, Jan Schepers, Monique R T M Thissen, Hugo J E M Alberts, Casper G Schalkwijk, Madelon L Peters
Psychological factors have been shown to influence the process of wound healing. This study examined the effect of Mindfulness-Based Stress Reduction (MBSR) on the speed of wound healing. The local production of pro-inflammatory cytokines and growth factors was studied as potential underlying mechanism. Forty-nine adults were randomly allocated to a waiting-list control group (n = 26) or an 8-week MBSR group (n = 23). Pre- and post-intervention/waiting period assessment for both groups consisted of questionnaires...
November 20, 2017: Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/29159203/varicella-zoster-virus-infected-cerebrovascular-cells-produce-a-proinflammatory-environment
#17
Dallas Jones, C Preston Neff, Brent E Palmer, Kurt Stenmark, Maria A Nagel
Objective: To test whether varicella zoster virus (VZV) infection of human brain vascular cells and of lung fibroblasts directly increases proinflammatory cytokine levels, consistent with VZV as a causative agent in intracerebral VZV vasculopathy and giant-cell arteritis (GCA). Methods: Conditioned supernatant from mock- and VZV-infected human brain vascular adventitial fibroblasts (HBVAFs), human perineurial cells (HPNCs), human brain vascular smooth muscle cells (HBVSMCs), and human fetal lung fibroblasts (HFLs) were collected at 72 hours postinfection and analyzed for levels of 30 proinflammatory cytokines using the Meso Scale Discovery Multiplex ELISA platform...
September 2017: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/29158121/systemic-cytokines-and-chemokines-on-admission-of-children-hospitalized-with-community-acquired-pneumonia
#18
Ângela G Vasconcellos, Jorge Clarêncio, Daniela Andrade, Maria-Regina A Cardoso, Aldina Barral, Cristiana M Nascimento-Carvalho
Community-acquired pneumonia (CAP) is the main cause of death in children under-5 years worldwide and Streptococcus pneumoniae is the most common bacterial agent. However, it is difficult to identify pneumococcal infection among children with CAP. We aimed to assess association between any cytokine/chemokine and pneumococcal infection in childhood CAP. Furthermore, we evaluated the diagnostic value of cytokine/chemokine for pneumococcal infection. This prospective study was conducted at an Emergency Room, in Salvador, Brazil...
November 17, 2017: Cytokine
https://www.readbyqxmd.com/read/29157921/pooling-of-bronchoalveolar-lavage-in-children-with-cystic-fibrosis-does-not-adversely-affect-the-microbiological-yield-or-sensitivity-in-detecting-pulmonary-inflammation
#19
Paul McNally, Jennifer O'Rourke, Emmanuelle Fantino, Archana Chacko, Rishi Pabary, Andrew Turnbull, Tim Grant, Niamh O'Sullivan, Claire Wainwright, Barry Linnane, Jane C Davies, Peter D Sly
BACKGROUND: Bronchoalveolar lavage (BAL) is a potentially useful outcome measure for clinical trials in children with CF but its use is limited by variations in approach internationally. We sought to determine if pooling adversely affected the diagnostic properties of BAL. METHODS: Children undergoing bronchoscopy for clinical reasons were included. A multi-step study protocol ensured BAL was collected and analysed both separately and as a pooled fluid. RESULTS: Eighty-five children (53 CF, 32 control) were recruited...
November 17, 2017: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://www.readbyqxmd.com/read/29157250/ozone-exposure-is-associated-with-acute-changes-in-inflammation-fibrinolysis-and-endothelial-cell-function-in-coronary-artery-disease-patients
#20
Jaime E Mirowsky, Martha Sue Carraway, Radhika Dhingra, Haiyan Tong, Lucas Neas, David Diaz-Sanchez, Wayne Cascio, Martin Case, James Crooks, Elizabeth R Hauser, Z Elaine Dowdy, William E Kraus, Robert B Devlin
BACKGROUND: Air pollution is a major risk factor for cardiovascular disease, of which ozone is a major contributor. Several studies have found associations between ozone and cardiovascular morbidity, but the results have been inconclusive. We investigated associations between ozone and changes across biological pathways associated with cardiovascular disease. METHODS: Using a panel study design, 13 participants with coronary artery disease were assessed for markers of systemic inflammation, heart rate variability and repolarization, lipids, blood pressure, and endothelial function...
November 21, 2017: Environmental Health: a Global Access Science Source
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