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Wei-Hai Chen, Guo-Feng Luo, Qi Lei, Sheng Hong, Wen-Xiu Qiu, Li-Han Liu, Si-Xue Cheng, Xian-Zheng Zhang
In this study, we developed a general method to decorate plasmonic gold nanorods (GNRs) with a CD44-targeting functional polymer, containing hyaluronic acid (HA) targeting moiety and a small molecule Glut1 inhibitor of diclofenac (DC), to obtain GNR/HA-DC. This nanosystem exhibited the superiority of selectively sensitizing tumor cells for photothermal therapy (PTT) by inhibiting the unique anaerobic glycolysis. Upon specifically targeting CD44, sequentially time-dependent DC release could be achieved by the trigger of hyaluronidase (HAase), which abundantly existed in tumor tissue...
January 20, 2017: ACS Nano
Yu Huang, Lingwei Ma, Jianghao Li, Zhengjun Zhang
We carefully present a numerical study of the nanoparticle (NP) faceting, highlighting the great influence of small morphological changes of the NP-mirror cavities on the near-field enhancement in the nanoparticle-on-mirror (NPOM) system. By 3D finite element method (FEM) plasmon mapping, the active transverse cavity modes can be confirmed. For the dominant mode, we have found that by increasing the facet width, the resonance can be tuned linearly to the red with little decrease of the peak near-field intensity...
January 20, 2017: Nanotechnology
Raed Alharbi, Mehrdad Irannejad, Mustafa Yavuz
Integrating plasmonic materials, like gold with a two-dimensional material (e.g., graphene) enhances the light-material interaction and, hence, plasmonic properties of the metallic nanostructure. A localized surface plasmon resonance sensor is an effective platform for biomarker detection. They offer a better bulk surface (local) sensitivity than a regular surface plasmon resonance (SPR) sensor; however, they suffer from a lower figure of merit compared to that one in a propagating surface plasmon resonance sensors...
January 19, 2017: Sensors
Deepti Diwan, Kohei Shinkai, Toshihiro Tetsuka, Bin Cao, Hidenao Arai, Tetsuo Koyama, Ken Hatano, Koji Matsuoka
Protein-carbohydrate interactions exhibit myriad intracellular recognition events, so understanding and investigating their specific interaction with high selectivity and strength are of crucial importance. In order to examine the effect of multivalent binding on the specificity of protein-carbohydrate interactions, we synthesized mannose glycosides as a novel type of glycosylated monomer and glycopolymers of polyacrylamide derivatives with α-mannose (α-Man) by radical polymerization and monitored their strength of interaction with concanavalin A (Con A) by surface plasmon resonance (SPR) detection...
January 18, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Romain Salza, Claire Lethias, Sylvie Ricard-Blum
The goals of this work were i) to identify the interactions of amyloid-β (Aβ)42 under monomeric, oligomeric, and fibrillar forms with the extracellular matrix (ECM) and receptors, ii) to determine the influence of Aβ42 supramolecular organization on these interactions, and iii) to identify the molecular functions, biological processes, and pathways targeted by Aβ42 in the ECM. The ECM and cell surface partners of Aβ42 and its supramolecular forms were identified with protein and glycosaminoglycan (GAG) arrays (81 molecules in triplicate) probed by surface plasmon resonance imaging...
January 18, 2017: Journal of Alzheimer's Disease: JAD
Matthias Schwartzkopf, Alexander Hinz, Oleksandr Polonskyi, Thomas Strunskus, Franziska Carina Löhrer, Volker Körstgens, Peter Muller-Buschbaum, Franz Faupel, Stephan V Roth
The reproducible low-cost fabrication of functional polymer-metal-interfaces via self-assembly is of crucial importance in organic electronics and organic photovoltaics. In particular, submonolayer and nanogranular systems expose highly interesting electrical, plasmonic and catalytical properties. The exploitation of their great potential requires tailoring of the structure on the nanometer scale and below. In order to obtain full control over the complex nanostructural evolution at the polymer-metal interface, we monitor the evolution of the metallic layer morphology with in situ time-resolved GISAXS during sputter deposition...
January 20, 2017: ACS Applied Materials & Interfaces
Xu Chen, Donglei Zhou, Wen Xu, Jinyang Zhu, Gencai Pan, Ze Yin, He Wang, Yongsheng Zhu, Cui Shaobo, Hongwei Song
Localized electric filed enhancement by surface plasmon resonance (SPR) of noble metal nanoparticles is an effective method to amplify the upconversion luminescence (UCL) strength of upconversion nanoparticles (UCNPs), whereas the highly effective UCL enhancement of UCNPs in colloids has not been realized until now. Here, we designed and fabricated the colloidal Au-Ag nanocage@NaYF4@NaYF4:Yb,Er core-shell hybrid with different intermediate thickness (NaYF4) and tunable SPR peaks from visible wavelength region to NIR region...
January 20, 2017: Scientific Reports
Haiyin Li, Jiafu Chang, Ting Hou, Feng Li
It is well-known that the horseradish peroxidase- (HRP-) mimicking DNAzyme, namely, hemin/G-quadruplex, can effectively catalyze the polymerization of aniline to form DNA-guided polyaniline. Meanwhile, polyaniline exhibits extraordinary electrical, electrochemical, and redox properties, as well as excellent SPR signal-enhancing ability. Herein, we report a novel ultrasensitive surface plasmon resonance (SPR) biosensor based on HRP-mimicking DNAzyme-catalyzed in situ formation of polyaniline for signal amplification, using bleomycin (BLM) as the proof-of-concept analyte...
January 3, 2017: Analytical Chemistry
Jinxia Xu, Zhenhuan Wang, Wenqing Li, Xingang Zhang, Dong He, Xiangheng Xiao
High specific surface area three-dimensional pine tree-like hierarchical TiO2 nanotube array films loaded with Ag nanoparticles were successfully prepared by one-step hydrothermal reaction combining with simple and feasible magnetron sputtering. The composite Ag/TiO2-branched nanotube arrays show outstanding photocatalytic property, which is attributed to the boost of plasmonic enhancement carrier generation and separation, higher specific surface area, higher organic pollutant absorption, faster charge transport, and superior light-harvesting efficiency for efficient charge collection...
December 2017: Nanoscale Research Letters
Helen Webb, Olga Steeb, Ashleigh Blane, Lia Rotherham, Shaun Aron, Phillip Machanick, Heini Dirr, Sylvia Fanucchi
FOXP2 is a member of the P subfamily of FOX transcription factors, the DNA binding domain of which is the winged helix forkhead domain. In this work we show that the FOXP2 forkhead domain is able to bind to various DNA sequences, including a novel sequence identified in this work, with different affinities and rates as detected using surface plasmon resonance. Combining the experimental work with molecular docking, we show that high affinity sequences remain bound to the protein for longer, form a greater number of interactions with the protein and induce a greater structural change in the protein than low affinity sequences...
January 18, 2017: Journal of Biochemistry
Sophia Böcker, Lothar Elling
Galectin-3 modulates cell adhesion and signaling events by specific binding and cross-linking galactoside containing carbohydrate ligands. Proteolytic cleavage by metalloproteinases yields in vivo N-terminally truncated galectin-3 still bearing the carbohydrate recognition domain. Truncated galectin-3 has been demonstrated to act in vivo as a negative inhibitor of galectin-3 due to higher affinity for carbohydrate ligands. We here present our studies on a series of twelve human galectin-3 protein constructs...
January 19, 2017: Glycobiology
Yu-Zhen Chen, Zhiyong U Wang, Hengwei Wang, Junling Lu, Shu-Hong Yu, Hai-Long Jiang
The selectivity control toward aldehyde in the aromatic alcohol oxidation remains a grand challenge using molecular oxygen under mild conditions. In this work, we have designed and synthesized Pt/PCN-224(M) composites by integration of Pt nanocrystals and porphyrinic metal-organic frameworks (MOFs), PCN-224(M). The composites exhibit excellent catalytic performance in the photo-oxidation of aromatic alcohols by 1 atm O2 at ambient temperature, based on synergetic photothermal effect and singlet oxygen production...
January 20, 2017: Journal of the American Chemical Society
Anna V Lomonosova, Andrei B Ulitin, Alexei S Kazakov, Tajib A Mirzabekov, Eugene A Permyakov, Sergei E Permyakov
Small antibody mimetics, or alternative binding proteins (ABPs), extend and complement antibody functionality with numerous applications in research, diagnostics and therapeutics. Given the superiority of ABPs, the last two decades have witnessed development of dozens of alternative protein scaffolds (APSs) for the design of ABPs. Proteins from extremophiles with their high structural stability are especially favorable for APS design. Here, a 10X mutant of the 50S ribosomal protein L35Ae from hyperthermophilic archaea Pyrococcus horikoshii has been probed as an APS...
2017: PloS One
Yiyang Lin, E Thomas Pashuck, Michael R Thomas, Nadav Amdursky, Shih-Ting Wang, Lesley W Chow, Molly M Stevens
Supramolecular self-assembly is an important process that enables the conception of complex structures mimicking biological motifs. Herein, we constructed helical fibrils through chiral self-assembly of nucleobase-peptide conjugates (NPCs), where achiral nucleobases are helically displayed on the surface of fibrils, comparable to polymerized nucleic acids. Selective binding between DNA and the NPC fibrils was observed with fluorescence polarization. Taking advantage of metal-nucleobase recognition, we highlight the possibility of deposition/assembly of plasmonic nanoparticles onto the fibrillar constructs...
January 19, 2017: Angewandte Chemie
Kyungtaek Min, Muhammad Umar, Shinyoung Ryu, Soonil Lee, Sunghwan Kim
Ultra-thin and ultra-smooth gold (Au) films are appealing for photonic applications including surface plasmon resonances and transparent contacts. However, poor adhesion at the Au���dielectric interface prohibits the formation of a mechanically stable, ultra-thin, and ultra-smooth Au film. A conventional solution is to use a metallic adhesion layer, such as titanium and chromium however, such layers cause the optical properties of pure Au to deteriorate. Here we report the use of silk protein to enhance the adhesion at the Au���dielectric interfaces, thus obtaining ultra-smooth sub-10 nm Au films...
January 19, 2017: Nanotechnology
Frank A W Coumans, Elmar L Gool, Rienk Nieuwland
There is increasing clinical interest in extracellular vesicles (EV) for diagnostic and treatment purposes. This review provides an overview of bulk immunoassays to analyse EV. Western blot and enzyme-linked immunosorbent assay are still the two predominant bulk immunoassays. Recently, new assays have become available that can detect exposure to EV concentrations that are up to 10,000-fold lower. This is advantageous for applications that detect rare EV. Other important parameters are the detectable concentration range, the required sample volume, whether simultaneous presence of different antigens on a single EV can be detected, size selectivity of each assay and practical considerations...
January 19, 2017: Platelets
Peter R Wiecha, Leo-Jay Black, Yudong Wang, Vincent Paillard, Christian Girard, Otto L Muskens, Arnaud Arbouet
Polarization control using single plasmonic nanoantennas is of interest for subwavelength optical components in nano-optical circuits and metasurfaces. Here, we investigate the role of two mechanisms for polarization conversion by plasmonic antennas: Structural asymmetry and plasmon hybridization through strong coupling. As a model system we investigate L-shaped antennas consisting of two orthogonal nanorods which lengths and coupling strength can be independently controlled. An analytical model based on field susceptibilities is developed to extract key parameters and to address the influence of antenna morphology and excitation wavelength on polarization conversion efficiency and scattering intensities...
January 19, 2017: Scientific Reports
Rozalina Zakaria, Siti Fatimah Az Zahra Yusoff, Kok Chung Law, Chin Seong Lim, Harith Ahmad
In this report, we experimentally investigate the formation of "flower-like silver structures" on graphene. Using an electrochemical deposition technique with deposition times of 2.5 and 5 min, agglomerations of silver nanoparticles (AgNPs) were deposited on the graphene surfaces, causing the formation of "flower-like structures" on the graphene substrate. Localized surface plasmon resonance (LSPR) was observed in the interaction between the structures and the graphene substrate. The morphology of the samples was observed using a field-emission scanning electron microscope (FESEM) and Raman spectroscopy...
December 2017: Nanoscale Research Letters
Ahmed Abumazwed, Wakana Kubo, Chen Shen, Takuo Tanaka, Andrew G Kirk
This paper presents a simple and accurate method (the projection method) to improve the signal to noise ratio of localized surface plasmon resonance (LSPR). The nanostructures presented in the paper can be readily fabricated by nanoimprint lithography. The finite difference time domain method is used to simulate the structures and generate a reference matrix for the method. The results are validated against experimental data and the proposed method is compared against several other recently published signal processing techniques...
January 1, 2017: Biomedical Optics Express
I G Mbomson, S Tabor, B Lahiri, G Sharp, S G McMeekin, R M De La Rue, N P Johnson
In this paper we report on a very sensitive biosensor based on gold asymmetric nanoantennas that are capable of enhancing the molecular resonances of C-H bonds. The nanoantennas are arranged as arrays of asymmetric-split H-shape (ASH) structures, tuned to produce plasmonic resonances with reflectance double peaks within the mid-infrared vibrational resonances of C-H bonds for the assay of deposited films of the molecule 17β-estradiol (E2), used as an analyte. Measurements and numerical simulations of the reflectance spectra have enabled an estimated enhancement factor on the order of 10(5) to be obtained for a thin film of E2 on the ASH array...
January 1, 2017: Biomedical Optics Express
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