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Zabit Hameed, Saqib Saleem, Jawad Mirza, Muhammad Salman Mustafa, Qamar-Ul-Islam
Epilepsy is a brain disorder characterised by the recurrent and unpredictable interruptions of normal brain function, called epileptic seizures. The present study attempts to derive new diagnostic indices which may delineate between ictal and interictal states of epilepsy. To achieve this, the nonlinear modeling approach of global principal dynamic modes (PDMs) is adopted to examine the functional connectivity of the temporal and frontal lobes with the occipital brain segment using an ensemble of paediatric EEGs having the presence of epileptic seizure...
2018: PloS One
Gregory Z Ferl, Arthur Reyes, Liping L Sun, Melissa Cheu, Amy Oldendorp, Saroja Ramanujan, Eric G Stefanich
CD20 is a cell-surface receptor expressed by healthy and neoplastic B cells and is a well-established target for biologics used to treat B-cell malignancies. Pharmacokinetic (PK) and pharmacodynamic (PD) data for the anti-CD20/CD3 T-cell-dependent bispecific antibody BTCT4465A were collected in transgenic mouse and nonhuman primate (NHP) studies. Pronounced nonlinearity in drug elimination was observed in the murine studies, and time-varying, nonlinear PK was observed in NHPs, where three empirical drug elimination terms were identified using a mixed-effects modeling approach: i) a constant nonsaturable linear clearance term (7 mL/day/kg); ii) a rapidly decaying time-varying, linear clearance term (t½  = 1...
January 19, 2018: Clinical and Translational Science
Azmat Ullah, Suheel Abdullah Malik, Khurram Saleem Alimgeer
In this paper, a hybrid heuristic scheme based on two different basis functions i.e. Log Sigmoid and Bernstein Polynomial with unknown parameters is used for solving the nonlinear heat transfer equations efficiently. The proposed technique transforms the given nonlinear ordinary differential equation into an equivalent global error minimization problem. Trial solution for the given nonlinear differential equation is formulated using a fitness function with unknown parameters. The proposed hybrid scheme of Genetic Algorithm (GA) with Interior Point Algorithm (IPA) is opted to solve the minimization problem and to achieve the optimal values of unknown parameters...
2018: PloS One
Jingzhou Xin, Jianting Zhou, Simon X Yang, Xiaoqing Li, Yu Wang
Bridges are an essential part of the ground transportation system. Health monitoring is fundamentally important for the safety and service life of bridges. A large amount of structural information is obtained from various sensors using sensing technology, and the data processing has become a challenging issue. To improve the prediction accuracy of bridge structure deformation based on data mining and to accurately evaluate the time-varying characteristics of bridge structure performance evolution, this paper proposes a new method for bridge structure deformation prediction, which integrates the Kalman filter, autoregressive integrated moving average model (ARIMA), and generalized autoregressive conditional heteroskedasticity (GARCH)...
January 19, 2018: Sensors
Jeng-Cheng Liu, Yuang-Tung Cheng, Hsien-Sen Hung
Direction-of-arrival (DOA) and range estimation is an important issue of sonar signal processing. In this paper, a novel approach using Hilbert-Huang transform (HHT) is proposed for joint bearing and range estimation of multiple targets based on a uniform linear array (ULA) of hydrophones. The structure of this ULA based on micro-electro-mechanical systems (MEMS) technology, and thus has attractive features of small size, high sensitivity and low cost, and is suitable for Autonomous Underwater Vehicle (AUV) operations...
January 19, 2018: Sensors
Katrin Tomson-Johanson, Jaanus Harro
PURPOSE OF REVIEW: To summarize the recent findings on the association of cholesterol levels with impulsivity and violence. RECENT FINDINGS: Several authors have recently highlighted the importance of confounding factors that mask the association between cholesterol and impulsivity or violent behaviour. In particular, demographic factors and presence of psychiatric disorders can play a role in the discrepancies present in literature. Men seem to be more sensitive to low cholesterol levels as the association between low cholesterol levels and aggression is found mostly in men...
January 17, 2018: Current Opinion in Endocrinology, Diabetes, and Obesity
Cătălin Paşcu Moca, Christophe Mora, Ireneusz Weymann, Gergely Zaránd
We construct a Fermi liquid theory to describe transport in a superconductor-quantum dot-normal metal junction close to the singlet-doublet (parity changing) transition of the dot. Though quasiparticles do not have a definite charge in this chargeless Fermi liquid, in the case of particle-hole symmetry, a mapping to the Anderson model unveils a hidden U(1) symmetry and a corresponding pseudocharge. In contrast to other correlated Fermi liquids, the back scattering noise reveals an effective charge equal to the charge of Cooper pairs, e^{*}=2e...
January 5, 2018: Physical Review Letters
Marc W Guetg, Alberto A Lutman, Yuantao Ding, Timothy J Maxwell, Franz-Josef Decker, Uwe Bergmann, Zhirong Huang
X-ray free-electron lasers combine a high pulse power, short pulse length, narrow bandwidth, and high degree of transverse coherence. Any increase in the photon pulse power, while shortening the pulse length, will further push the frontier on several key x-ray free-electron laser applications including single-molecule imaging and novel nonlinear x-ray methods. This Letter shows experimental results at the Linac Coherent Light Source raising its maximum power to more than 300% of the current limit while reducing the photon pulse length to 10 fs...
January 5, 2018: Physical Review Letters
Chiao-Yu Cheng, Rijul Dhanker, Christopher L Gray, Sukrit Mukhopadhyay, Eric R Kennehan, John B Asbury, Anatoliy Sokolov, Noel C Giebink
We report strong coupling between light and polaron optical excitations in a doped organic semiconductor microcavity at room temperature. Codepositing MoO_{3} and the hole transport material 4, 4^{'}-cyclohexylidenebis[N, N-bis(4-methylphenyl)benzenamine] introduces a large hole density with a narrow linewidth optical transition centered at 1.8 eV and an absorption coefficient exceeding 10^{4}  cm^{-1}. Coupling this transition to a Fabry-Pérot cavity mode yields upper and lower polaron polariton branches that are clearly resolved in angle-dependent reflectivity with a vacuum Rabi splitting ℏΩ_{R}>0...
January 5, 2018: Physical Review Letters
G Cao, J Terzic, H D Zhao, H Zheng, L E De Long, Peter S Riseborough
Electrical control of structural and physical properties is a long-sought, but elusive goal of contemporary science and technology. We demonstrate that a combination of strong spin-orbit interactions (SOI) and a canted antiferromagnetic Mott state is sufficient to attain that goal. The antiferromagnetic insulator Sr_{2}IrO_{4} provides a model system in which strong SOI lock canted Ir magnetic moments to IrO_{6} octahedra, causing them to rigidly rotate together. A novel coupling between an applied electrical current and the canting angle reduces the Néel temperature and drives a large, nonlinear lattice expansion that closely tracks the magnetization, increases the electron mobility, and precipitates a unique resistive switching effect...
January 5, 2018: Physical Review Letters
Zhao Huang, Shuaifeng Li, Xin Liu, Degang Zhao, Lei Ye, Xuefeng Zhu, Jianfeng Zang
Optical interface states exhibit promising applications in nonlinear photonics, low-threshold lasing, and surface-wave assisted sensing. However, the further application of interface states in configurable optics is hindered by their limited tunability. Here, we demonstrate a new approach to generate dynamically tunable and angle-resolved interface states using graphene-embedded photonic crystal (GPC) heterostructure device. By combining the GPC structure design with in situ electric doping of graphene, a continuously tunable interface state can be obtained and its tuning range is as wide as the full bandgap...
January 19, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
Megan M Reynolds
Growing research on the political economy of health has begun to emphasize sociopolitical influences on cross-national differences in population health above and beyond economic growth. While this research investigates the impact of overall public health spending as a share of GDP ("health care effort"), it has for the most part overlooked the distribution of health care spending across the public and private spheres ("public sector share"). I evaluate the relative contributions of health care effort, public sector share, and GDP to the large and growing disadvantage in U...
January 1, 2018: International Journal of Health Services: Planning, Administration, Evaluation
Aurel A Lazar, Nikul H Ukani, Yiyin Zhou
We investigate the sparse functional identification of complex cells and the decoding of spatio-temporal visual stimuli encoded by an ensemble of complex cells. The reconstruction algorithm is formulated as a rank minimization problem that significantly reduces the number of sampling measurements (spikes) required for decoding. We also establish the duality between sparse decoding and functional identification and provide algorithms for identification of low-rank dendritic stimulus processors. The duality enables us to efficiently evaluate our functional identification algorithms by reconstructing novel stimuli in the input space...
January 18, 2018: Journal of Mathematical Neuroscience
Byung-Hwan Lee, Sun-Hye Choi, Hyeon-Joong Kim, Sang-Deuk Park, Hyewhon Rhim, Hyoung-Chun Kim, Sung-Hee Hwang, Seung-Yeol Nah
Background: Recently, we identified a novel ginseng-derived lysophosphatidic acid receptor ligand, called gintonin. We showed that gintonin induces [Ca2+]i transient-mediated morphological changes, proliferation, and migration in cells expressing lysophosphatidic acid receptors and that oral administration of gintonin exhibits anti-Alzheimer disease effects in model mice. However, little is known about the intestinal absorption of gintonin. The aim of this study was to investigate gintonin absorption using two model systems...
January 2018: Journal of Ginseng Research
A Curcio, A Marocchino, V Dolci, S Lupi, M Petrarca
In this paper, an alternative perspective for the generation of millimetric high-gradient resonant plasma waves is discussed. This method is based on the plasma-wave excitation by energetic single-cycle THz pulses whose temporal length is comparable to the plasma wavelength. The excitation regime discussed in this paper is the quasi-nonlinear regime that can be achieved when the normalized vector potential of the driving THz pulse is on the order of unity. To investigate this regime and determine the strength of the excited electric fields, a Particle-In-Cell (PIC) code has been used...
January 18, 2018: Scientific Reports
N Roy, P Sanz-Leon, P A Robinson
The modulation of neural quantities by presynaptic and postsynaptic activities via local feedback processes is investigated by incorporating nonlinear phenomena such as relative refractory period, synaptic enhancement, synaptic depression, and habituation. This is done by introducing susceptibilities, which quantify the response in either firing threshold or synaptic strength to unit change in either presynaptic or postsynaptic activity. Effects on the power spectra are then analyzed for a realistic corticothalamic model to determine the spectral signatures of various nonlinear processes and to what extent these are distinct...
November 2017: Physical Review. E
Lucianno A C A Defaveri, Welles A M Morgado, Sílvio M Duarte Queirós
We propose a method that makes use of the nonlinear properties of some hypothetical microscopic solid material as the working substance for a microscopic machine. The protocols used are simple (step and elliptic) and allow us to obtain the work and heat exchanged between machine and reservoirs. We calculate the work for a nonlinear single-particle machine that can be treated perturbingly. We obtain the instantaneous work and heat for the machine undergoing cycles that mimic the Carnot and multireservoir protocols...
November 2017: Physical Review. E
Sebastian Eydam, Matthias Wolfrum
We investigate the dynamics of a Kuramoto-type system of globally coupled phase oscillators with equidistant natural frequencies and a coupling strength below the synchronization threshold. It turns out that in such cases one can observe a stable regime of sharp pulses in the mean field amplitude with a pulsation frequency given by spacing of the natural frequencies. This resembles a process known as mode locking in lasers and relies on the emergence of a phase relation induced by the nonlinear coupling. We discuss the role of the first and second harmonics in the phase-interaction function for the stability of the pulsations and present various bifurcating dynamical regimes such as periodically and chaotically modulated mode locking, transitions to phase turbulence, and intermittency...
November 2017: Physical Review. E
A V Zakharov, P V Maslennikov
The thermally excited vortical flow in a microsized liquid crystal (LC) volume with a free LC-air interface has been investigated theoretically based on the nonlinear extension of the Ericksen-Leslie theory, with accounting the entropy balance equation. Analysis of the numerical results show that due to interaction between the gradients of the director field ∇n[over ̂] and temperature field ∇T, caused by the focused heating, the thermally excited vortical fluid flow is maintained in the vicinity of the heat source...
November 2017: Physical Review. E
Nathan Perchikov, O V Gendelman
Local configurational symmetry in lattice structures may give rise to stationary, compact solutions, even in the absence of disorder and nonlinearity. These compact solutions are related to the existence of flat dispersion curves (bands). Nonlinearity can destabilize such compactons. One common flat-band-generating system is the one-dimensional cross-stitch model, in which compactons were shown to exist for the photonic lattice with Kerr nonlinearity. The compactons exist there already in the linear regime and are not generally destructed by that nonlinearity...
November 2017: Physical Review. E
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