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Endocrine surgery

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https://www.readbyqxmd.com/read/29931061/successful-targeted-therapies-for-breast-cancer-the-worcester-foundation-and-future-opportunities-in-women-s-health
#1
Balkees Abderrahman, V Craig Jordan
The signing of the National Cancer Act in 1971, was designed to take laboratory discoveries rapidly from the bench to the bedside. A "war on cancer" had been declared. Combination cytotoxic chemotherapy was predicted to cure all cancers based on the stunning success in treating childhood leukemia. Breast cancer treatments were primitive; radical mastectomy and radiation was standard of care for disease that had not spread. Ablative endocrine surgery (oophorectomy, hypophysectomy, and adrenalectomy) was a palliative last option for metastatic breast cancer...
June 19, 2018: Endocrinology
https://www.readbyqxmd.com/read/29929755/narrowing-of-the-surgical-resident-operative-experience-a-27-year-analysis-of-national-acgme-case-logs
#2
Alexander R Cortez, Gianna D Katsaros, Vikrom K Dhar, F Thurston Drake, Timothy A Pritts, Jeffrey J Sussman, Michael J Edwards, R Cutler Quillin
BACKGROUND: Although overall operative volume has remained stable since the implementation of duty hours, more detailed analyses suggest shifts in the resident operative experience. Understanding these differences allows educators to better appreciate the impact of the current training environment on resident preparation for practice. METHODS: National Accreditation Council for Graduate Medical Education case logs from 1990 to 2016 were reviewed. Statistical analysis was performed using analysis of variance and linear regression analysis...
June 18, 2018: Surgery
https://www.readbyqxmd.com/read/29925170/-microsurgical-resection-of-sellar-tumors-via-lateral-supraorbital-approach-clinical-analysis-of-20-cases
#3
X Y Lu, X J Fu, H H Zeng, Y Yao, L Wang
Objective: To research the application of lateral supraorbital (LOS) approach for resecting sellar tumors. Methods: Clinical symptoms of 20 patients with surgery via LOS approach were analyzed retrospectively.According to the neuroradiological findings and the improvement of symptoms, and some score scale, the efficacy and safety of LOS were assessed for removing sellar tumors.There were tuberculum sellae meningioma ( n =11), craniopharyngioma ( n =4), epidermoid cysts ( n =4) and pituitary adenoma ( n =1)...
June 19, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29924022/management-of-testicular-leydig-cell-tumor-a-case-report
#4
Jianguo Zhu, Yun Luan, Haige Li
RATIONALE: Testicular Leydig cell tumor (LCT) is a rare neoplasm. It commonly presents as a painless testicular mass with or without endocrine changes. Histological and immunohistochemical examination play important roles in differentiating LCT from testicular germ cell tumors. PATIENT CONCERNS: We highlight the imaging phenotype, as well as the pathological findings of a case of LCT in a 62-year-old male. DIAGNOSES: Preoperative noncontrast CT scan of the abdomen revealed a 7...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29911027/is-a-surgeon-performed-ultrasound-good-enough-in-diagnosing-thyroid-malignancy
#5
Gajarajan Mohanapriya, Maharajan Chandrasekaran
Background: The widespread availability of ultrasonography has facilitated the evaluation of thyroid nodules, to differentiate between malignant and benign nodules and between metastatic and reactive lymph nodes. From the radiologists' suite, ultrasound has moved into the surgeon's office. Aim: The aim of the present study was to evaluate the relevance of surgeon-performed ultrasound (SPUS) in the diagnosis of malignancy of the thyroid. Methods: SPUS for 389 consecutive patients attending the outpatient department of endocrine surgery in a tertiary care institute in Chennai...
March 2018: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29910227/postoperative-growth-hormone-dynamics-in-clinically-nonfunctioning-pituitary-adenoma
#6
Nobuyuki Kobayashi, Mitsuo Yamaguchi-Okada, Kentaro Horiguchi, Noriaki Fukuhara, Hiroshi Nishioka, Shozo Yamada
Growth hormone deficiency (GHD) is an endocrine disorder characterized by insufficient production of growth hormone (GH). Non-functioning pituitary adenoma (NFPA) is one of common causes of GHD. Although most patients with NFPA have transsphenoidal surgery, the time-dependent changes in GH after operation have yet to be investigated. In this study, we analyzed patients with NFPAs that underwent transsphenoidal surgery. Postoperatively, GH secretion was evaluated in response to GH-releasing peptide-2 (GHRP2) infusion...
June 15, 2018: Endocrine Journal
https://www.readbyqxmd.com/read/29909222/fallopian-tube-tumorigenesis-and-clinical-implications-for-ovarian-cancer-risk-reduction
#7
REVIEW
Allison A Gockley, Kevin M Elias
Ovarian cancer remains the leading cause of gynecologic cancer death among American women. Prevention is the only proven approach to reduce the incidence of the disease. Oral contraception, tubal ligation, and risk-reducing salpingo-oophorectomy (rrBSO) for high-risk groups are all established risk reduction strategies. This paradigm is changing as recent biologic studies suggest that many ovarian cancers, especially high-grade serous ovarian cancers, originate in the distal end of the fallopian tube rather than the ovarian surface epithelium...
June 11, 2018: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/29901576/anterior-interhemispheric-approach-for-removing-large-sellar-region-tumor
#8
Shi-Yu Feng, Tao Zhou, Zheng-Hui Sun, Bo Bu, Jin-Li Jiang
The aim of the study was to explore anterior interhemispheric approach microsurgery for removing large sellar region tumors.A total of 118 patients with large sellar region tumors were treated with the anterior interhemispheric approach microsurgery. There were 58 craniopharyngioma, 37 pituitary adenoma, 5 hypothalamic glioma, 7 meningioma, and 11 other tumors cases. The maximal tumor diameter ranged from 3.0 to 8.2 cm, with a mean diameter of 4.3 cm. Diabetes insipidus and fluid and electrolyte imbalance were timely controlled after surgery...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29900476/mixed-adenoneuroendocrine-carcinoma-of-the-esophagogastric-junction-a-case-report
#9
Miho Yamamoto, Soji Ozawa, Kazuo Koyanagi, Junya Oguma, Akihito Kazuno, Yamato Ninomiya, Kentaro Yatabe, Kazuhito Hatanaka
BACKGROUND: Mixed adenoneuroendocrine carcinoma (MANEC) is a tumor of the gastrointestinal tract that contains both exocrine and endocrine components, with each component exceeding 30% of the total tumor area. Because MANECs are exceedingly rare, no therapeutic strategies have been established yet. CASE PRESENTATION: An 81-year-old man was referred to our hospital with a 5-month history of dysphagia. Esophagogastroduodenoscopy revealed an ulcerated mass in the lower thoracic esophagus, extending up to the esophagogastric junction (33 to 40 cm from the incisors)...
June 14, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/29897580/recent-topics-around-multiple-endocrine-neoplasia-type-1
#10
Stephen J Marx
Introduction: Multiple endocrine neoplasia type 1 (MEN1) is complex with regard to clinical expressions, management, and molecular pathways. Advances are being made broadly and in focused aspects. Selected topics are presented for their developments since publication of the most recent MEN1 consensus guidelines 6 years ago. Methods: Topics were selected for clinical impact or broad interest or both. For each topic, information was obtained from original reports and reviews...
April 1, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29895525/the-hypothalamic-pituitary-adrenal-axis-in-childhood-cancer-survivors
#11
Christina Wei, Elizabeth Crowne
Endocrine abnormalities are common among childhood cancer survivors. Abnormalities of the hypothalamic-pituitary-adrenal axis (HPAA) are the least common, but the consequences are severe if missed. Patients with tumours located and /or had surgery performed near the hypothalamic-pituitary region and those treated with an accumulative cranial radiotherapy dose of over 30 Gy are most at risk of adrenocorticotrophic hormone (ACTH) deficiency. Primary adrenal insufficiency may occur in patients with tumours located in or involving one or both adrenals...
June 12, 2018: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29891521/receipt-of-guideline-concordant-care-among-older-women-with-stage-i-iii-breast-cancer-a-population-based-study
#12
Traci LeMasters, S Suresh Madhavan, Usha Sambamoorthi, Hannah W Hazard-Jenkins, Kimberly M Kelly, Dustin Long
Background: This study examined receipt of guideline-concordant care (GCC) according to evidence-based treatment guidelines and quality measures and specific types of treatment among older women with breast cancer. Patients and Methods: A total of 142,433 patients aged ≥66 years diagnosed with stage I-III breast cancer between 2007 and 2011 were identified in the SEER-Medicare linked database. Algorithms considering cancer characteristics and the appropriate course of care as per guidelines versus actual care received determined receipt of GCC...
June 2018: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/29891226/evaluation-and-treatment-of-gender-dysphoria-to-prepare-for-gender-confirmation-surgery
#13
REVIEW
Miriam Hadj-Moussa, Dana A Ohl, William M Kuzon
BACKGROUND: Gender dysphoria is the experience of marked distress due to incongruence between genetically determined gender and experienced gender. Treatment of gender dysphoria should be individualized and multidisciplinary, involving a combination of psychotherapy, social gender transition, cross-sex hormone therapy, gender-affirming surgery, and/or ancillary procedures and services. The goal of all treatment modalities is to alleviate distress and affirm the patient's experienced gender identity...
June 8, 2018: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/29886106/the-role-of-central-pancreatectomy-in-pancreatic-surgery-a-systematic-review-and-meta-analysis
#14
REVIEW
Weidong Xiao, Jisheng Zhu, Long Peng, Le Hong, Gen Sun, Yong Li
BACKGROUND: The aim of this systematic review and meta-analysis was to compare the clinical outcomes of central pancreatectomy (CP) with distal pancreatectomy (DP) and pancreaticoduodenectomy (PD). METHODS: A systematic literature research in PubMed/Medline, Embase and Cochrane Library was performed to identify articles reporting CP from January 1983 to November 2017. RESULTS: Fifty studies with 1305 patients undergoing CP were identified...
June 6, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29881371/new-insights-in-cushing-disease-treatment-with-focus-on-a-derivative-of-vitamin-a
#15
REVIEW
Mariana Fuertes, Julieta Tkatch, Josefina Rosmino, Leandro Nieto, Mirtha Adriana Guitelman, Eduardo Arzt
Cushing's disease (CD) is an endocrine disorder originated by a corticotroph tumor. It is linked with high mortality and morbidity due to chronic hypercortisolism. Treatment goals are to control cortisol excess and achieve long-term remission, therefore, reducing both complications and patient's mortality. First-line of treatment for CD is pituitary's surgery. However, 30% of patients who undergo surgery experience recurrence in long-term follow-up. Persistent or recurrent CD demands second-line treatments, such as pituitary radiotherapy, adrenal surgery, and/or pharmacological therapy...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29881286/clinicopathologic-features-and-radiation-therapy-utilization-in-patients-with-male-breast-cancer-a-national-cancer-database-study
#16
REVIEW
Joshua Weir, Yan Daniel Zhao, Terence Herman, Özer Algan
Male breast cancer (MBC) accounts for approximately 1% of all breast cancers, limiting the data characterizing clinicopathologic features and treatment outcomes in patients with MBC. This paucity of data has led to most of our treatment guidance being extrapolated from patients with female breast cancer (FBC). From 1998 to 2012, data were captured using the National Cancer Database to identify patients with nonmetastatic MBC (n = 23 305) and FBC (n = 2 678 061). Tumor and clinicopathologic features were obtained and compared...
2018: Breast Cancer: Basic and Clinical Research
https://www.readbyqxmd.com/read/29880706/management-of-endocrine-disease-hypophysitis-diagnosis-and-treatment
#17
Mamta N Joshi, Benjamin Whitelaw, Paul V Carroll
Hypophysitis is a rare condition characterised by inflammation of the pituitary gland, usually resulting in hypopituitarism and pituitary enlargement. Pituitary inflammation can occur as a primary hypophysitis (most commonly lymphocytic, granulomatous or xanthomatous disease) or as secondary hypophysitis (as a result of systemic diseases, immunotherapy or alternative sella based pathologies). Hypophysitis can be classified using anatomical, histopathological and aetiological criteria. Non-invasive diagnosis of hypophysitis remains elusive, and the use of currently available serum anti-pituitary antibodies are limited by low sensitivity and specificity...
June 7, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29875471/variation-in-treatment-and-survival-of-older-patients-with-non-metastatic-breast-cancer-in-five-european-countries-a-population-based-cohort-study-from-the-eurecca-breast-cancer-group
#18
Marloes G M Derks, Esther Bastiaannet, Mandy Kiderlen, Denise E Hilling, Petra G Boelens, Paul M Walsh, Elizabeth van Eycken, Sabine Siesling, John Broggio, Lynda Wyld, Maciej Trojanowski, Agnieszka Kolacinska, Justyna Chalubinska-Fendler, Ana Filipa Gonçalves, Tomasz Nowikiewicz, Wojciech Zegarski, Riccardo A Audisio, Gerrit-Jan Liefers, Johanneke E A Portielje, Cornelis J H van de Velde
BACKGROUND: Older patients are poorly represented in breast cancer research and guidelines do not provide evidence based recommendations for this specific group. We compared treatment strategies and survival outcomes between European countries and assessed whether variance in treatment patterns may be associated with variation in survival. METHODS: Population-based study including patients aged ≥ 70 with non-metastatic BC from cancer registries from the Netherlands, Belgium, Ireland, England and Greater Poland...
June 7, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29874142/new-agents-emerging-late-effects-and-the-development-of-precision-survivorship
#19
Eric J Chow, Zoltan Antal, Louis S Constine, Rebecca Gardner, W Hamish Wallace, Brent R Weil, Jennifer M Yeh, Elizabeth Fox
Incremental improvements in the treatment of children and adolescents with cancer have led to 5-year survival rates reaching nearly 85%. In the past decade, impressive progress has been made in understanding the biology of many pediatric cancers. With that understanding, multiple new agents have become available that offer the promise of more-effective and less-toxic treatment. These include agents that target various cell surface antigens and engage the adaptive immune system, as well as those that interfere with key signaling pathways involved in tumor development and growth...
June 6, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29869750/laryngeal-basaloid-squamous-cell-carcinoma-with-a-substantial-spindle-cell-component-case-presentation-and-updated-review-of-literature
#20
Deepak Pandiar, Sangeetha K Nayanar, Basavaraj Ankalkoti, Sajith Babu
Basaloid squamous cell carcinoma with spindle cell component is an uncommon aggressive variety of squamous cell carcinoma with only a few reported cases in literature. Histologically a combination of basaloid squamous cell carcinoma and spindle cell squamous cell carcinoma is appreciated and immunohistochemistry serves a role in differentiation from malignant neoplasms of salivary gland or neuro-endocrine origin. Prime treatment modality is combination of surgery and external beam radiotherapy. A case of basaloid squamous cell carcinoma with proliferation of bizarre mesenchymal component is being reported here with an updated literature review...
June 5, 2018: Head and Neck Pathology
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