keyword
MENU ▼
Read by QxMD icon Read
search

Leptin resistance

keyword
https://www.readbyqxmd.com/read/29766568/cord-blood-insulin-igf-i-igf-ii-leptin-adiponectin-and-ghrelin-and-their-associations-with-insulin-sensitivity-%C3%AE-cell-function-and-adiposity-in-infancy
#1
D L Zhang, Q Du, A Djemli, P Julien, W D Fraser, Z C Luo
AIM: Vulnerability to insulin resistance and Type 2 diabetes may originate in early life, but little is known about whether any perinatal biomarkers are predictive of later metabolic health. We sought to assess whether cord blood insulin, insulin-like growth factor (IGF)-I, IGF-II, leptin, adiponectin and ghrelin are associated with metabolic health indicators in infancy. METHODS: In a prospective singleton birth cohort, we assessed cord blood insulin, IGF-I, IGF-II, leptin, adiponectin and ghrelin concentrations in relation to the homeostasis model assessment of insulin resistance (HOMA-IR), β-cell function (HOMA-β), fasting proinsulin-to-insulin ratio, BMI z-score, and the sum of triceps and subscapular skinfold thickness (an indicator of adiposity) in infants at age 1 year (n = 185)...
May 15, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29760587/the-role-of-adipokines-in-skeletal-muscle-inflammation-and-insulin-sensitivity
#2
REVIEW
Thomas Nicholson, Chris Church, David J Baker, Simon W Jones
Background: There is currently an unmet clinical need to develop better pharmacological treatments to improve glucose handling in Type II Diabetes patients with obesity. To this end, determining the effect of obesity-associated adipokines on skeletal muscle insulin sensitivity has emerged as an important area of drug discovery research. This review draws together the data on the functional role of adipokines on skeletal muscle insulin signalling, highlights several understudied novel adipokines and provides a perspective on the direction of future research...
2018: Journal of Inflammation
https://www.readbyqxmd.com/read/29759068/childhood-retinol-binding-protein-4-rbp4-levels-predicting-the-10-year-risk-of-insulin-resistance-and-metabolic-syndrome-the-bcams-study
#3
Ge Li, Issy C Esangbedo, Lu Xu, Junling Fu, Lujiao Li, Dan Feng, Lanwen Han, Xinhua Xiao, Mingyao Li, Jie Mi, Ming Li, Shan Gao, Steven M Willi
BACKGROUND: Elevated retinol-binding protein 4 (RBP4) levels may contribute to the development of metabolic abnormalities, but prospective studies evaluating the association between childhood RBP4 levels and metabolic syndrome (MS) in adulthood are lacking. We investigated whether RBP4 levels during childhood predict cardiometabolic risk at 10-year follow-up. METHODS: The relationships between RBP4 levels, the established adipokines (leptin and adiponectin) and the components of MS were examined in 3445 school-aged children recruited in 2004 for the Beijing Child and Adolescent Metabolic Syndrome study...
May 14, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29755549/evaluation-of-diabetogenic-mechanism-of-high-fat-diet-in-combination-with-arsenic-exposure-in-male-mice
#4
Akram Ahangarpour, Soheila Alboghobeish, Mohsen Rezaei, Mohammad Javad Khodayar, Ali Akbar Oroojan, Marzieh Zainvand
Obesity is a main reason of type 2 diabetes and also chronic exposure to arsenic (As) can produce diabetic symptoms. In previous studies, the association between high-fat diet and arsenic in the incidence of diabetes was found, but the role of beta cells activity, liver mitochondrial oxidative stress, and hepatic enzymes (leptin, adiponectin and beta amylase) was unclear. Thus, present study was conducted to evaluate the diabetogenic mechanism of arsenic followed by concomitant administration of high-fat diet (HFD) in male mice...
2018: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/29748097/time-resolved-hypothalamic-open-flow-micro-perfusion-reveals-normal-leptin-transport-across-the-blood-brain-barrier-in-leptin-resistant-mice
#5
Maximilian Kleinert, Petra Kotzbeck, Thomas Altendorfer-Kroath, Thomas Birngruber, Matthias H Tschöp, Christoffer Clemmensen
OBJECTIVE: The inability of leptin to suppress food intake in diet-induced obesity, sometimes referred to as leptin resistance, is associated with several distinct pathological hallmarks. One prevailing theory is that impaired transport of leptin across the blood-brain barrier (BBB) represents a molecular mechanism that triggers this phenomenon. Recent evidence, however, has challenged this notion, suggesting that leptin BBB transport is acquired during leptin resistance. METHODS: To resolve this debate, we utilized a novel cerebral Open Flow Microperfusion (cOFM) method to examine leptin BBB transport in male C57BL/6J mice, fed a chow diet or high fat diet (HFD) for 20 days...
April 27, 2018: Molecular Metabolism
https://www.readbyqxmd.com/read/29747813/biology-of-gm3-ganglioside
#6
Jin-Ichi Inokuchi, Kei-Ichiro Inamori, Kazuya Kabayama, Masakazu Nagafuku, Satoshi Uemura, Shinji Go, Akemi Suzuki, Isao Ohno, Hirotaka Kanoh, Fumi Shishido
Since the successful molecular cloning in 1998 of GM3 synthase (GM3S, ST3GAL5), the enzyme responsible for initiating biosynthesis of all complex gangliosides, the efforts of our research group have been focused on clarifying the physiological and pathological implications of gangliosides, particularly GM3. We have identified isoforms of GM3S proteins having distinctive lengths of N-terminal cytoplasmic tails, and found that these cytoplasmic tails define subcellular localization, stability, and in vivo activity of GM3S isoforms...
2018: Progress in Molecular Biology and Translational Science
https://www.readbyqxmd.com/read/29745909/a-young-adult-with-generalized-lipodystrophy-and-diabetes-mellitus-case-report
#7
E Çelo, B Kalari, F Toti
Lipodystrophies are a group of heterogeneous disorders characterized by varying degrees of body fat loss and predisposition to insulin resistance and its metabolic complications. Lipodystrophy associated metabolic abnormalities include insulin resistance, that often lead to diabetes mellitus and its complications, hypertriglyceridemia that may be severe enough to cause acute pancreatitis, and hepatic steatosis that may lead to cirrhosis. We present the case of an 18-year-old female who was hospitalized as an inaugural Diabetes Mellitus...
April 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29742429/diet-induced-growth-is-regulated-via-acquired-leptin-resistance-and-engages-a-pomc-somatostatin-growth-hormone-circuit
#8
Heiko Löhr, Simon Hess, Mafalda M A Pereira, Philip Reinoß, Sandra Leibold, Christel Schenkel, Claudia M Wunderlich, Peter Kloppenburg, Jens C Brüning, Matthias Hammerschmidt
Anorexigenic pro-opiomelanocortin (Pomc)/alpha-melanocyte stimulating hormone (αMSH) neurons of the hypothalamic melanocortin system function as key regulators of energy homeostasis, also controlling somatic growth across different species. However, the mechanisms of melanocortin-dependent growth control still remain ill-defined. Here, we reveal a thus-far-unrecognized structural and functional connection between Pomc neurons and the somatotropic hypothalamo-pituitary axis. Excessive feeding of larval zebrafish causes leptin resistance and reduced levels of the hypothalamic satiety mediator pomca...
May 8, 2018: Cell Reports
https://www.readbyqxmd.com/read/29738274/renal-injury-in-seipin-deficient-lipodystrophic-mice-and-its-reversal-by-adipose-tissue-transplantation-or-leptin-administration-alone-adipose-tissue-kidney-crosstalk
#9
Xue-Jing Liu, Xiao-Yue Wu, Huan Wang, Su-Xia Wang, Wei Kong, Ling Zhang, George Liu, Wei Huang
Seipin deficiency is responsible for type 2 congenital generalized lipodystrophy with severe loss of adipose tissue (AT) and could lead to renal failure in humans. However, the effect of Seipin on renal function is poorly understood. Here we report that Seipin knockout (SKO) mice exhibited impaired renal function, enlarged glomerular and mesangial surface areas, renal depositions of lipid, and advanced glycation end products. Elevated glycosuria and increased electrolyte excretion were also detected. Relative renal gene expression in fatty acid oxidation and reabsorption pathways were impaired in SKO mice...
May 8, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29733056/asociaci%C3%A3-n-de-leptina-con-factores-cardiometab%C3%A3-licos-en-escolares-y-adolescentes-con-hiperplasia-suprarrenal-cong%C3%A3-nita
#10
Jessie Nallely Zurita-Cruz, Miguel Ángel Villasís-Keever, Leticia Damasio-Santana, Leticia Manuel-Apolinar, Rosalba Ferrusca-Ceja, Elisa Nishimura-Meguro, Aleida de J Rivera-Hernández, Eulalia Garrido-Magaña
Introducción: En la hiperplasia suprarrenal congénita (HSC), la obesidad, la hiperinsulinemia y los niveles de leptina se encuentran incrementados. Objetivo: Identificar la frecuencia de los factores de riesgo cardiometabólico (FRC) en niños y adolescentes con HSC y explorar la relación con los niveles de leptina. Método: Estudio transversal de 40 pacientes a quienes se realizó somatometría y evaluación de glucosa, insulina, triglicéridos, 17-hidroxiprogesterona, leptina, colesterol HDL y LDL en ayuno...
2018: Gaceta Médica de México
https://www.readbyqxmd.com/read/29723106/therapeutic-effect-of-acupoint-catgut-embedding-in-abdominally-obese-women-a-randomized-double-blind-placebo-controlled-study
#11
I-Ju Chen, Yuh-Hsiang Yeh, Chung-Hua Hsu
INTRODUCTION: Acupuncture and electroacupuncture have been proved to be beneficial in weight control among obese women. Acupoint catgut embedding treatment, a derivative type of acupuncture, is considered to be more effective than acupuncture and electroacupuncture in reducing weight. This study is to investigate the therapeutic effects and safety of acupoint stimulation by catgut embedding in obese women. The influence of catgut embedding on obesity-related hormones was also examined...
May 3, 2018: Journal of Women's Health
https://www.readbyqxmd.com/read/29722904/renal-complications-of-lipodystrophy-a-closer-look-at-the-natural-history-of-kidney-disease
#12
Baris Akinci, Sadiye Mehtat Unlu, Ali Celik, Ilgin Yildirim Simsir, Sait Sen, Banu Nur, Fatma Ela Keskin, Basak Ozgen Saydam, Nilufer Ozdemir Kutbay, Banu Sarer Yurekli, Bekir Ugur Ergur, Melda Sonmez, Tahir Atik, Atakan Arslan, Tevfik Demir, Canan Altay, Ulku Aybuke Tunc, Tugba Arkan, Ramazan Gen, Erdal Eren, Gulcin Akinci, Aslihan Arasli Yilmaz, Habip Bilen, Samim Ozen, Aygul Celtik, Senay Savas Erdeve, Semra Cetinkaya, Huseyin Onay, Sulen Sarioglu, Elif Arioglu Oral
OBJECTIVES: Lipodystrophy syndromes are a group of heterogeneous disorders characterized by adipose tissue loss. Proteinuria is a remarkable finding in previous reports. STUDY DESIGN: In this multi-center study, prospective follow-up data were collected from 103 subjects with non-HIV associated lipodystrophy registered in the Turkish Lipodystrophy Study Group database to study renal complications in treatment naïve patients with lipodystrophy. METHODS: Main outcome measures included ascertainment of chronic kidney disease (CKD) by studying the level of proteinuria and the estimated glomerular filtration rate (eGFR)...
May 3, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29722816/higher-cord-blood-levels-of-fatty-acids-in-pregnant-women-with-type-1-diabetes-mellitus
#13
Josip Djelmis, Marina Ivaniševic, Gernot Desoye, Mireille van Poppel, Edina Berberovic, Dragan Soldo, Slavko Oreskovic
Context: Type 1 diabetes mellitus is associated with a disturbance of carbohydrate and lipid metabolism. Objective: To determine whether type 1 diabetes mellitus (T1DM) alters maternal and neonatal fatty acid levels. Design: Observational study. Setting: Academic hospital. Patients: Sixty pregnant women (30 women with T1DM with good glycemic control and 30 healthy women) were included in the study...
May 1, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29721071/adipocyte-derived-exosomal-mir-27a-induces-insulin-resistance-in-skeletal-muscle-through-repression-of-ppar%C3%AE
#14
Yang Yu, Hongwei Du, Shengnan Wei, Linjing Feng, Junnan Li, Fan Yao, Ming Zhang, Grant M Hatch, Li Chen
The mechanism by which adipocyte-derived endocrine factors promote insulin resistance in skeletal muscle are not fully understood. MiR-27a is highly expressed in sera of obese individuals with prediabetes and T2DM, and mainly derived by adipose tissues. Thus, miR-27a secreted into circulation by adipose tissue may regulate insulin resistance in skeletal muscle. Methods: The association between miR-27a and insulin resistance in skeletal muscle was determined in obese children, high-fat diet-induced miR-27a knockdown obese mice, db/db mice and C2C12 cells overexpressing miR-27a...
2018: Theranostics
https://www.readbyqxmd.com/read/29717885/time-restricted-feeding-of-a-high-fat-diet-in-c57bl-6-male-mice-reduces-adiposity-but-does-not-protect-against-increased-systemic-inflammation
#15
Laura B Delahaye, Richard J Bloomer, Matthew B Butawan, Jacqueline M Wyman, Jessica L Hill, Harold W Lee, Andrew C Liu, Liam McAllan, Joan C Han, Marie van der Merwe
Time-restricted feeding (TRF) limits duration of food availability without altering diet composition and can combat obesity in humans and mice. For this study we evaluated the effect of timing of food access during a TRF protocol on weight gain, adiposity and inflammation. Young C57BL/6 male mice were placed on a 45% high fat (HF) diet for 8 weeks. Food access was unrestricted (HF) or restricted to 6 hours per day, either for the first half (HF-early) or the second half (HF-late) of the active phase to resemble a window of time for food consumption early <u><i></u>vs<u></i></u> late in the day in a human population...
May 2, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29717270/biological-and-psychological-mediators-of-the-relationships-between-fat-mass-fat-free-mass-and-energy-intake
#16
Mark Hopkins, Graham Finlayson, Cristiana Duarte, Catherine Gibbons, Alexandra M Johnstone, Stephen Whybrow, Graham W Horgan, John E Blundell, R James Stubbs
BACKGROUND: While recent studies in humans indicate that fat-free mass (FFM) is closely associated with energy intake (EI) when in energy balance, associations between fat mass (FM) and EI are inconsistent. OBJECTIVES: The present study used a cross-sectional design to examine the indirect and direct effects of FFM, FM and resting metabolic rate (RMR) on EI in individuals at or close to energy balance. METHODS: Data for 242 individuals (114 males; 128 females; BMI = 25...
March 13, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29716676/high-prevalence-of-metabolic-syndrome-in-antisynthetase-syndrome
#17
Paula A O Araujo, Marilda Guimarães Silva, Eduardo Ferreira Borba, Samuel K Shinjo
OBJECTIVES: A high frequency of metabolic syndrome (MetS) has been recently described in different idiopathic inflammatory myopathies, but not in antisynthetase syndrome (ASS). Therefore, the aim of the present study was to determine the prevalence of MetS in ASS and also its possible association with cardiovascular the risk factors and ASS-related disease characteristics. METHODS: A cross-sectional single centre study of 42 consecutive ASS patients was conducted from 2012 to 2015 and compared to 84 healthy individuals matched for gender, age, ethnicity and body mass index-matched (control group)...
March 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29715187/possible-association-of-ghrelin-obestatin-balance-with-cardiometabolic-risk-in-obese-subjects-with-helicobacter-pylori
#18
Azza Saad Ibrahim, Mona Mohamed Eldeeb, Ola Ahmed Salama, Mona Mohamed Rashad, Khaled Mohamed Okasha
OBJECTIVES: Helicobacter pylori (H. pylori) is a common gastric infection associated with extragastric conditions. The association between H. pylori infection and obesity is unclear. H. pylori may affect gut hormones involved in food intake and energy expenditure. The aim of this study is to evaluate ghrelin/obestatin balance and leptin in obese subjects with H. pylori infection. METHODS: Sixty healthy volunteers were divided into: obese and non-obese groups. Each group was divided into H...
April 1, 2018: Endocrine Regulations
https://www.readbyqxmd.com/read/29713567/palmitic-acid-induces-neurotoxicity-and-gliatoxicity-in-sh-sy5y-human-neuroblastoma-and-t98g-human-glioblastoma-cells
#19
Yee-Wen Ng, Yee-How Say
Background: Obesity-related central nervous system (CNS) pathologies like neuroinflammation and reactive gliosis are associated with high-fat diet (HFD) related elevation of saturated fatty acids like palmitic acid (PA) in neurons and astrocytes of the brain. Methods: Human neuroblastoma cells SH-SY5Y (as a neuronal model) and human glioblastoma cells T98G (as an astrocytic model), were treated with 100-500 µM PA, oleic acid (OA) or lauric acid (LA) for 24 h or 48 h, and their cell viability was assessed by 3-(4,5-dimetylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay...
2018: PeerJ
https://www.readbyqxmd.com/read/29696568/the-relationship-between-adiposopathy-and-glucose-insulin-homeostasis-is-not-affected-by-moderate-intensity-aerobic-training-in-healthy-women-with-obesity
#20
Andrée-Anne Clément, Eléonor Riesco, Sébastien Tessier, Michel Lacaille, Francine Pérusse, Mélanie Coté, Jean-Pierre Després, John Weisnagel, Jean Doré, Denis R Joanisse, Pascale Mauriège
The contribution of adiposopathy to glucose-insulin homeostasis remains unclear. This longitudinal study examined the potential relationship between the adiponectin/leptin ratio (A/L, a marker of adiposopathy) and insulin resistance (IR: homeostasis model assessment (HOMA)), insulin sensitivity (IS: Matsuda), and insulin response to an oral glucose tolerance test before and after a 16-week walking program, in 29 physically inactive pre- and postmenopausal women with obesity (BMI, 29-35 kg/m2 ; age, 47-54 years)...
April 26, 2018: Journal of Physiology and Biochemistry
keyword
keyword
12576
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"