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https://www.readbyqxmd.com/read/29045965/-cause-analysis-of-spinal-surgery-in-ankylosing-spondylitis
#1
R Liu, L Sun, C H Li, J Y Zhai, X Y Liu
OBJECTIVE: To investigate the common cause of spinal surgery in ankylosing spondylitis (AS) and to develop reasonable and effective treatment programs for rhematologists. METHODS: In this study, 79 AS patients (72 males, 7 females) hospitalized in the Department of Orthopedic and received spinal surgery in Peking University Third Hospital from January 2007 to July 2013 were investigated retrospectively. The causes of the spinal surgery were analyzed. RESULTS: The majority of the surgery were of cervical vertebra surgery for 59 cases (74...
October 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29044129/priming-with-fgf2-stimulates-human-dental-pulp-cells-to-promote-axonal-regeneration-and-locomotor-function-recovery-after-spinal-cord-injury
#2
Kosuke Nagashima, Takahiro Miwa, Hitomi Soumiya, Daisuke Ushiro, Tomoko Takeda-Kawaguchi, Naritaka Tamaoki, Saho Ishiguro, Yumi Sato, Kei Miyamoto, Takatoshi Ohno, Masatake Osawa, Takahiro Kunisada, Toshiyuki Shibata, Ken-Ichi Tezuka, Shoei Furukawa, Hidefumi Fukumitsu
Human dental pulp cells (DPCs), adherent cells derived from dental pulp tissues, are potential tools for cell transplantation therapy. However, little work has been done to optimize such transplantation. In this study, DPCs were treated with fibroblast growth factor-2 (FGF2) for 5-6 consecutive serial passages and were transplanted into the injury site immediately after complete transection of the rat spinal cord. FGF2 priming facilitated the DPCs to promote axonal regeneration and to improve locomotor function in the rat with spinal cord injury (SCI)...
October 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29043562/a-review-of-the-management-of-tibial-plateau-fractures
#3
REVIEW
J Mthethwa, A Chikate
Tibial plateau fractures form a wide spectrum of injuries presenting varying challenges to the trauma surgeon. The prognosis of this injury spectrum is largely dependent on the management of each particular configuration, and the literature is as a result littered with a number of management strategies with limited consensus. The aim of this review is to provide a concise guide to the trauma surgeon based on newer and classical peer-reviewed publications in international orthopaedic journals. A PubMed search was conducted to identify peer-reviewed publications within the last 10 years and expanded to identify classic papers pertaining to the Schatzker classification...
October 17, 2017: Musculoskeletal Surgery
https://www.readbyqxmd.com/read/29042825/antithrombotics-in-trauma-management-strategies-in-the-older-patients
#4
REVIEW
Henna Wong, Nicola Lovett, Nicola Curry, Ku Shah, Simon J Stanworth
The ageing population has resulted in a change in the demographics of trauma, and older adult trauma now accounts for a growing number of trauma admissions. The management of older adult trauma can be particularly challenging, and exhibits differences to that of the younger age groups affected by trauma. Frailty syndromes are closely related with falls, which are the leading cause of major trauma in older adults. Comorbid disease and antithrombotic use are more common in the older population. Physiological changes that occur with ageing can alter the expected clinical presentation of older persons after injury and their susceptibility to injury...
2017: Journal of Blood Medicine
https://www.readbyqxmd.com/read/29042786/interpersonal-sensitivity-mediates-the-effects-of-child-abuse-and-affective-temperaments-on-depressive-symptoms-in-the-general-adult-population
#5
Ayano Otsuka, Yoshikazu Takaesu, Mitsuhiko Sato, Jiro Masuya, Masahiko Ichiki, Ichiro Kusumi, Takeshi Inoue
BACKGROUND: Recent studies have suggested that multiple factors interact with the onset and prognosis of major depressive disorders. In this study, we investigated how child abuse, affective temperaments, and interpersonal sensitivity are interrelated, and how they affect depressive symptoms in the general adult population. SUBJECTS AND METHODS: A total of 415 volunteers from the general adult population completed the Patient Health Questionnaire-9, the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego-Autoquestionnaire version, the Child Abuse and Trauma Scale, and the Interpersonal Sensitivity Measure, which are all self-administered questionnaires...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29042693/occult-sources-of-bleeding-in-blunt-trauma-a-narrative-review
#6
REVIEW
Tetsuya Yumoto, Yoshinori Kosaki, Yasuaki Yamakawa, Atsuyoshi Iida, Hirotsugu Yamamoto, Taihei Yamada, Kohei Tsukahara, Hiromichi Naito, Takaaki Osako, Atsunori Nakao
Worldwide, hemorrhagic shock in major trauma remains a major potentially preventable cause of death. Controlling bleeding and subsequent coagulopathy is a big challenge. Immediate assessment of unidentified bleeding sources is essential in blunt trauma patients with hemorrhagic shock. Chest/pelvic X-ray in conjunction with ultrasonography have been established classically as initial diagnostic imaging modalities to identify the major sources of internal bleeding including intra-thoracic, intra-abdominal, or retroperitoneal hemorrhage related to pelvic fracture...
October 2017: Acta Medica Okayama
https://www.readbyqxmd.com/read/29042388/is-overseas-volunteering-beneficial-to-the-nhs-the-analysis-of-volunteers-responses-to-a-feedback-questionnaire-following-experiences-in-low-income-and-middle-income-countries
#7
Daniel Yeomans, Grace Le, Hemant Pandit, Chris Lavy
INTRODUCTION: Locally requested and planned overseas volunteering in low-income and middle-income countries by National Health Service (NHS) staff can have benefits for the host or receiving nation, but its impact on the professional development of NHS staff is not proven. The Knowledge and Skills Framework (KSF) and Leadership Framework (LF) are two tools used by employers as a measure of individuals' development. We have used dimensions from both tools as a method of evaluating the benefit to NHS doctors who volunteer overseas...
October 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/29042263/facility-level-factors-and-outcomes-after-skilled-nursing-facility-admission-for-trauma-and-surgical-patients
#8
Lucas W Thornblade, Saman Arbabi, David R Flum, Qian Qiu, Vanessa J Fawcett, Giana H Davidson
OBJECTIVE: Patients discharged to skilled nursing facilities (SNFs) have worse outcomes than those discharged to home, but whether this is due to differences in facility-level factors in addition to patient characteristics is not known. We aimed to determine whether SNF-level factors including nurse staffing and patient density are associated with outcomes after acute hospitalization for trauma or surgery. DESIGN, SETTING, PARTICIPANTS, AND MEASUREMENTS: Retrospective study of patients discharged to Medicare-certified SNFs after trauma or major surgery from 2007 to 2009...
October 14, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/29042090/the-natural-history-of-flail-chest-injuries
#9
Kamil Naidoo, Layth Hanbali, Peter Bates
PURPOSE: Flail chest (FC) injuries represent a significant burden on trauma services because of its high morbidity and mortality. Current gold standard conservative management strategies for FC, are now being challenged by renewed interest in surgical rib fixation. This retrospective epidemiological study sets out to evaluate FC patients, and quantify the natural history of this injury by studying the injury patterns, epidemiology and mortality of patients sustaining FC injuries admitted to a major trauma centre (MTC)...
September 19, 2017: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
https://www.readbyqxmd.com/read/29040235/acetabular-fractures-in-children-and-adolescents-comparison-of-isolated-acetabular-fractures-and-acetabular-fractures-associated-with-pelvic-ring-injuries
#10
Christiane G Kruppa, Debra L Sietsema, Justin D Khoriaty, Marcel Dudda, Thomas A Schildhauer, Clifford B Jones
OBJECTIVES: To compare mechanism of injury, fracture pattern, displacement, clinical and radiographic outcome of isolated acetabular fractures (Group 1) versus acetabular fractures associated with a pelvic ring injury (Group 2). DESIGN: Retrospective cohort comparative analysis. SETTING: Private orthopaedic practice associated with a level one teaching trauma center. MAIN OUTCOME MEASUREMENTS: Mechanism of injury, fracture pattern, displacement and treatment, Glasgow Coma Scale (GCS), Injury Severity Score (ISS), leg length discrepancy (LLD) and hip dysplasia...
October 7, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/29040207/trauma-pneumonectomy-for-major-thoracic-bleeding-when-should-we-consider-about-it
#11
Martin L Tonglet, Didier Moens, Vincenzo D'Orio, Alexandre Ghuysen
No abstract text is available yet for this article.
October 16, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29040200/geospatial-mapping-can-be-used-to-identify-geographic-areas-and-social-factors-associated-with-intentional-injury-as-targets-for-prevention-efforts-distinct-to-a-given-community
#12
C H Lasecki, F C Mujica, S Stutsman, A Y Williams, L Ding, J D Simmons, S B Brevard
BACKGROUND: Geographic information systems (GIS) have proven effective in studying intentional injury in various communities; however, GIS is not implemented widely for use by level I trauma centers in understanding patient populations. Our study of intentional injury combines the capabilities of GIS with a level I trauma center registry to determine the spatial distribution of victims and correlated socioeconomic factors. METHODS: 1,099 out of 3,109 total incidents of intentional trauma in the trauma registry from 2005-2015 had sufficient street address information to be mapped in GIS...
October 16, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29038686/the-assessment-of-psychopathology-among-traumatized-refugees-measurement-invariance-of-the-harvard-trauma-questionnaire-and-the-hopkins-symptom-checklist-25-across-five-linguistic-groups
#13
Tim R Wind, Niels van der Aa, Simone de la Rie, Jeroen Knipscheer
Background: Questionnaires are widely used to assess the mental health status of refugees, whereas their construct validity largely remains unexplored. Objective: This study examined the construct validity of two widely-used instruments for the assessment of PTSD symptoms (Harvard Trauma Questionnaire [HTQ]; 16 items) and symptoms of anxiety and depression (Hopkins Symptom Check list-25 [HSCL-25]; 25 items) among Dutch and refugee patients with different linguistic backgrounds. Method: We applied exploratory factor analyses and measurement invariance analyses to test construct validity...
2017: European Journal of Psychotraumatology
https://www.readbyqxmd.com/read/29038298/subversion-of-nk-cell-and-tnf-alpha-immune-surveillance-drives-tumor-recurrence
#14
Timothy Kottke, Laura Evgin, Kevin G Shim, Diana Rommelfanger, Nicolas Boisgerault, Shane Zaidi, Rosa Maria Diaz, Jill Thompson, Elizabeth Ilett, Matt Coffey, Peter Selby, Hardev Pandha, Kevin Harrington, Alan Melcher, Richard Vile
Understanding how incompletely cleared primary tumors transition from minimal residual disease (MRD) into treatment resistant, immune-invisible recurrences has major clinical significance. We show here that this transition is mediated through the subversion of two key elements of innate immune surveillance. In the first, the role of TNFalpha changes from an antitumor effector against primary tumors into a growth promoter for MRD. Second, whereas primary tumors induced a natural killer (NK)-mediated cytokine response characterized by low IL6 and elevated IFNgamma, PD-L1hi MRD cells promoted the secretion of IL6 but minimal IFNgamma, inhibiting both NK cell and T-cell surveillance...
October 15, 2017: Cancer Immunology Research
https://www.readbyqxmd.com/read/29035965/effectiveness-of-bedrails-in-preventing-falls-among-hospitalized-older-adults-a-systematic-review
#15
Paulo Marques, Carmen Queirós, João Apóstolo, Daniela Cardoso
BACKGROUND: Falls are a major problem today affecting adults of any age, but the elderly are a population that is more susceptible to falls. Falls are the leading cause of injury or death among older adults. Hospitalized older people are particularly vulnerable to falls. Falls cause direct injuries (minor injuries, severe wounds of the soft tissues and bone fractures) to patients and increased length of stay. The prevention of falls is commonly considered an indicator of the quality of care...
October 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/29035141/usual-care-for-maltreatment-related-pediatric-posttraumatic-stress-disorder-in-germany
#16
Annika Münzer, Rita Rosner, Helene Gertrud Ganser, Alexander Naumann, Paul Lukas Plener, Andreas Witt, Lutz Goldbeck
Child maltreatment represents a major risk factor for the development of emotional and behavioral problems, especially posttraumatic stress disorder (PTSD). While effective trauma-focused treatments are available, little is known about the usual mental healthcare for abused youths in Germany. The present study compared the utilization of mental healthcare in abused youths who had developed a PTSD (N = 95) with a group presenting other mental disorders (N = 146). Semistructured interviews were used to assess maltreatment histories, current mental health, and healthcare utilization...
October 16, 2017: Zeitschrift Für Kinder- und Jugendpsychiatrie und Psychotherapie
https://www.readbyqxmd.com/read/29034645/peripheral-neuropathy-in-multiple-sclerosis-an-electrophysiologic-study-in-iranian-patients
#17
Mohammad Reza Emad, Leila Zeinali, Alireza Nikseresht, Mahshid Naseri, Hajar Karimian
Multiple sclerosis (MS) is the most common cause of disability after trauma in young adults in Northern Hemisphere; it imposes a major burden on the affected young people. A significant association between MS and demyelinating peripheral neuropathy which might be due to common pathogenesis for the central and peripheral nerves demyelination has been reported in several studies. We aimed to assess if there is any peripheral nervous system involvement in a sample of Iranian MS population. Extensive nerve conduction studies (NCS) were conducted in 20 MS patients according to McDonald criteria, and 20 age and gender matched healthy appearing controls...
August 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/29034608/nanoparticle-based-therapeutics-for-brain-injury
#18
REVIEW
Vimala N Bharadwaj, Duong T Nguyen, Vikram D Kodibagkar, Sarah E Stabenfeldt
Brain injuries affect a large patient population with major physical and emotional suffering for patients and their relatives; at a significant cost to the society. Effective diagnostic and therapeutic options available for brain injuries are limited by the complex brain injury pathology involving blood-brain barrier (BBB). Brain injuries, including ischemic stroke and brain trauma, initiate BBB opening for a short period of time, which is followed by a second reopening for an extended time. The leaky BBB and/or the alterations in the receptor expression on BBB may provide opportunities for therapeutic delivery via nanoparticles (NPs)...
October 16, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29032977/analysis-of-factor-xia-factor-ixa-and-tissue-factor-activity-in-burn-patients
#19
Jeffrey W Shupp, Shannon M Prior, Daniel Y Jo, Lauren T Moffatt, Kenneth G Mann, Saulius Butenas
INTRODUCTION: An elevated procoagulant activity observed in trauma patients is, in part, related to tissue factor (TF) located on blood cells and microparticles. However, analysis of trauma patient plasma indicates that there are other contributor(s) to the procoagulant activity. We hypothesize that factor (F)XIa and FIXa are responsible for an additional procoagulant activity in burn patients. METHODS: Multiple time-point plasma samples from 56 burn patients (total number of samples was 471; up to 20 time-points/patient collected in 3 weeks following admission) were evaluated in a thrombin generation assay using inhibitory antibodies to TF, FIXa and FXIa...
October 9, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29032474/discrepancy-between-the-initial-assessment-of-injury-severity-and-post-hoc-determination-of-injury-severity-in-patients-with-apparently-mild-traumatic-brain-injury-a-retrospective-multicenter-cohort-analysis
#20
S M Bossers, K M Pol, E P A Oude Ophuis, B Jacobs, M C Visser, S A Loer, C Boer, J van der Naalt, P Schober
PURPOSE: Traumatic brain injury (TBI) is a major cause of trauma-related visits to emergency departments (ED). Determination of monitoring requirements of patients with apparently mild TBI is challenging. Patients may turn out to be more severely injured than initially assumed, and failure to identify these patients constitutes a serious threat to patient safety. We, therefore, aimed to identify clinical risk factors for more severe injuries in patients with apparently mild TBI. METHODS: In a retrospective cohort analysis performed at two level I trauma centers, 808 patients aged ≥ 16 presenting to the ED with head trauma and a Glasgow Coma Scale (GCS) score 13-15 who received a head CT scan were studied...
October 14, 2017: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
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