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https://www.readbyqxmd.com/read/29684628/inflammatory-markers-and-their-possible-effects-on-cognitive-function-in-women-with-posttraumatic-stress-disorder
#1
Risa Imai, Hiroaki Hori, Mariko Itoh, Mingming Lin, Madoka Niwa, Keiko Ino, Sei Ogawa, Makiko Ishida, Atsushi Sekiguchi, Mie Matsui, Hiroshi Kunugi, Tatsuo Akechi, Toshiko Kamo, Yoshiharu Kim
Posttraumatic stress disorder (PTSD) has been associated with increased inflammation, albeit with some controversy. Another key feature of PTSD is compromised function in wide-ranging cognitive domains. Increased peripheral inflammation can contribute to cognitive dysfunction, although this relationship has not been studied in patients with PTSD. Here, we examined blood inflammatory markers in adult patients with PTSD compared to healthy controls taking account of potentially confounding effects of childhood maltreatment and comorbid major depressive disorder (MDD), and explored the association between inflammation and cognition...
April 13, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29682837/massive-transfusion-changing-practice-in-a-single-norwegian-centre-2002-2015
#2
H Doughty, T O Apelseth, J Sivertsen, K Annaniasen, T Hervig
OBJECTIVES: To describe the change in massive transfusion (MT) practice in a single Norwegian centre throughout the period 2002-2015. BACKGROUND: MT support for traumatic haemorrhage has changed since the mid-2000s. However, life-threatening haemorrhage may occur in other clinical specialties. In 2007, Haukeland University Hospital (HUS) introduced a universal MT programme including education, Acute Transfusion Packages (ATPs) and thromboelastography. METHODS/MATERIALS: A retrospective review was performed of all MT episodes defined as ≥10 red cell concentrates (RCC) in 24 h...
April 23, 2018: Transfusion Medicine
https://www.readbyqxmd.com/read/29682389/blunt-pancreatic-injury-in-major-trauma-decision-making-between-nonoperative-and-operative-treatment
#3
Christopher Ull, Sebastian Bensch, Thomas Armin Schildhauer, Justyna Swol
Blunt trauma injuries to the pancreas are rare but are associated with significant overall mortality and a high complication rate. Motor vehicle collisions are the leading cause of blunt pancreatic trauma, followed by falls, and sports injuries. We discuss the decision-making process used during the clinical courses of 3 patients with life-threatening blunt pancreatic injuries caused by traumatic falls. We also discuss the utility of the American Association for the Surgery of Trauma Organ Injury Scale (AAST-OIS), which provides a system for grading pancreatic trauma...
2018: Case Reports in Surgery
https://www.readbyqxmd.com/read/29682033/diagnostic-and-prognostic-capability-of-newer-magnetic-resonance-imaging-brain-sequences-in-diffuse-axonal-injury-patient
#4
Mayank Bansal, Virendra Deo Sinha, Juhi Bansal
Objectives: Diffuse axonal injury is one of the major causes of unconsciousness, profound neurologic deficits and persistent vegetative state after head trauma. In recent years, MR imaging has been gaining popularity as an adjunctive imaging method in patients with DAI. Our study aims to assess the relative diagnostic and prognostic capability of various MRI sequences. Patients and Methods: Retrospective observational study done in 1 year duration on 30 DAI patients...
April 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29682003/differentiation-in-an-inclusive-trauma-system-allocation-of-lower-extremity-fractures
#5
F S Würdemann, D P J Smeeing, S Ferree, F Nawijn, E J M M Verleisdonk, L P H Leenen, R M Houwert, F Hietbrink
Background: Implementation of an inclusive trauma system leads to reduced mortality rates, specifically in polytrauma patients. Field triage is essential in this mortality reduction. Triage systems are developed to identify patients with life-threatening injuries, and trauma mechanisms are important for triaging. Although complex extremity fractures are mostly non-lethal, these injuries are frequently the result of a high-energy trauma mechanism. The aim of this study is to compare injury and patient characteristics, as well as resource demands, of lower extremity fractures between a level (L)1 and level (L)2 trauma centre in a mature inclusive trauma system...
2018: World Journal of Emergency Surgery: WJES
https://www.readbyqxmd.com/read/29680414/financial-stability-of-level-i-trauma-centers-within-safety-net-hospitals
#6
Lisa M Knowlton, Arden M Morris, Lakshika Tennakoon, David A Spain, Kristan L Staudenmayer
BACKGROUND: Level I trauma centers often exist within Safety-Net Hospitals (SNHs), facilities servicing high proportions of low-income and uninsured patients. Given the current healthcare funding environment, trauma centers within SNHs may be at particular risk. Using California as a model, we hypothesized that SNHs with trauma centers vary in terms of financial stability. STUDY DESIGN: A retrospective cohort study using data from publically-available financial disclosure reports from California's Office of Statewide Health Planning and Development...
April 19, 2018: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29679414/rates-and-features-of-methamphetamine-related-presentations-to-emergency-departments-an-integrative-literature-review
#7
REVIEW
Rikki Jones, Cindy Woods, Kim Usher
AIMS AND OBJECTIVES: To review the clinical impact methamphetamine has on emergency departments (ED) by assessing the available research on the rates and features of methamphetamine-related presentations. BACKGROUND: Globally, methamphetamine availability, distribution and use has rapidly increased. As a result, the number of methamphetamine-related presentations to EDs has also increased. In this context, it is timely to review the rate and features of methamphetamine-related presentations to understand the impact of methamphetamine on EDs and facilitate the allocation of services, staff and resources...
April 20, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29678775/involvement-of-gap-junctions-in-astrocyte-impairment-induced-by-manganese-exposure
#8
Cailing Lu, Zhijuan Meng, Yiyuan He, Deqiang Xiao, Haiqing Cai, Yilu Xu, Xianghong Liu, Xinhang Wang, Laiming Mo, Ziwei Liang, Xuejing Wei, Qingqing Ao, Boying Liang, Xiyi Li, Shen Tang, Songchao Guo
Glutamate excitotoxicity, characterized as excessive glutamate stress, is considered to be involved in cerebral ischaemia, brain trauma, and neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease. Glutamate homeostasis disruption was highlighted in Mn neurotoxicity caused by high levels of Mn. Astrocytes, accounting for approximately 50% of the neuronal cells in the central nervous system and maintain glutamate homeostasis, are sensitive to neurotoxicity induced by Mn exposure. Astrocytes are tightly coupled with gap junctions (GJ), which are comprised of connexins, mainly connexin43 (Cx43)...
April 17, 2018: Brain Research Bulletin
https://www.readbyqxmd.com/read/29678686/trends-in-vena-cava-filter-insertions-and-prophylactic-use
#9
John R Power, Kenneth R Nakazawa, Ageliki G Vouyouka, Peter L Faries, Natalia N Egorova
BACKGROUND: Prophylactic vena cava filter (VCF) use in patients without venous thromboembolism is common practice despite ongoing controversy. Thorough analysis of the evolution of this practice is lacking. We describe trends in VCF use and identify events associated with changes in practice. METHODS: Using the National Inpatient Sample, we conducted a retrospective observational study of U.S. adult hospitalizations from 2000 to 2014. Trends in prophylactic VCF insertion were analyzed both across the entire study population and within subgroups according to trauma status and type of concurrent surgery...
April 17, 2018: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/29677216/plasma-metabolomic-biomarkers-accurately-classify-acute-mild-traumatic-brain-injury-from-controls
#10
Massimo S Fiandaca, Mark Mapstone, Amin Mahmoodi, Thomas Gross, Fabio Macciardi, Amrita K Cheema, Kian Merchant-Borna, Jeffrey Bazarian, Howard J Federoff
Past and recent attempts at devising objective biomarkers for traumatic brain injury (TBI) in both blood and cerebrospinal fluid have focused on abundance measures of time-dependent proteins. Similar independent determinants would be most welcome in diagnosing the most common form of TBI, mild TBI (mTBI), which remains difficult to define and confirm based solely on clinical criteria. There are currently no consensus diagnostic measures that objectively define individuals as having sustained an acute mTBI. Plasma metabolomic analyses have recently evolved to offer an alternative to proteomic analyses, offering an orthogonal diagnostic measure to what is currently available...
2018: PloS One
https://www.readbyqxmd.com/read/29677057/newborn-resuscitation-skills-in-health-care-providers-at-a-zambian-tertiary-center-and-comparison-to-world-health-organization-standards
#11
Sara C Mistry, Richard Lin, Hazel Mumphansha, Laura C Kettley, Janaki A Pearson, Sonia Akrimi, David J Mayne, Wonder Hangoma, M Dylan Bould
BACKGROUND: Birth asphyxia is a leading cause of early neonatal death. In 2013, 32% of neonatal deaths in Zambia were attributable to birth asphyxia and trauma. Basic, timely interventions are key to improving outcomes. However, data from the World Health Organization suggest that resuscitation is often not initiated, or is conducted suboptimally. Currently, there are little data on the quality of newborn resuscitation in the context of a tertiary center in a lower-middle income country...
April 17, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29675749/evaluation-of-severe-and-fatal-injuries-in-extreme-and-contact-sports-an-international-multicenter-analysis
#12
Christian D Weber, Klemens Horst, Anthony R Nguyen, Rolf Lefering, Hans-Christoph Pape, Frank Hildebrand
PURPOSE: The participation in extreme and contact sports has grown internationally, despite the significant risk for major and multiple injuries. We conducted this multicenter study to evaluate sport-specific injury patterns and mechanisms, to characterize individuals at risk and to identify possible approaches for prevention. METHODS: We compared demographic data, severity and patterns of injuries; and the pre- and in-hospital management from an international population-based prospective trauma database (TraumaRegister DGU®)...
April 19, 2018: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29675023/increased-plasma-levels-of-danger-associated-molecular-patterns-are-associated-with-immune-suppression-and-postoperative-infections-in-patients-undergoing-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy
#13
Guus P Leijte, Hettie Custers, Jelle Gerretsen, Amon Heijne, Johannes Roth, Thomas Vogl, Gert J Scheffer, Peter Pickkers, Matthijs Kox
Introduction: Danger-associated molecular patterns (DAMPs) can elicit immune responses and may subsequently induce an immune-suppressed state. Previous work showed that increased plasma levels of DAMPs are associated with immune suppression and increased susceptibility toward infections in trauma patients. Like trauma, major surgical procedures, such as cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC), are also thought to cause profound DAMP release...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29674451/fully-reduced-hmgb1-accelerates-the-regeneration-of-multiple-tissues-by-transitioning-stem-cells-to-g-alert
#14
Geoffrey Lee, Ana Isabel Espirito Santo, Stefan Zwingenberger, Lawrence Cai, Thomas Vogl, Marc Feldmann, Nicole J Horwood, James K Chan, Jagdeep Nanchahal
A major discovery of recent decades has been the existence of stem cells and their potential to repair many, if not most, tissues. With the aging population, many attempts have been made to use exogenous stem cells to promote tissue repair, so far with limited success. An alternative approach, which may be more effective and far less costly, is to promote tissue regeneration by targeting endogenous stem cells. However, ways of enhancing endogenous stem cell function remain poorly defined. Injury leads to the release of danger signals which are known to modulate the immune response, but their role in stem cell-mediated repair in vivo remains to be clarified...
April 19, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29673266/level-of-agreement-between-medical-record-and-icd-10-am-coding-of-mental-health-alcohol-and-drug-conditions-in-trauma-patients
#15
Tu Q Nguyen, Pamela M Simpson, Sandra C Braaf, Peter A Cameron, Rodney Judson, Belinda J Gabbe
BACKGROUND: Despite the reliance on administrative data in epidemiological studies, there is little information on the completeness of co-morbidities in administrative data coded from medical records. OBJECTIVE: The aim of this study was to quantify the agreement between the International Classification of Diseases, Tenth Revision, Australian Modification (ICD-10-AM) administrative coding of mental health, drug and alcohol co-morbidities and medical records in a severely injured patient population...
January 1, 2018: Health Information Management: Journal of the Health Information Management Association of Australia
https://www.readbyqxmd.com/read/29672992/life-in-the-fast-lane-settled-pastoralism-in-the-central-eurasian-steppe-during-the-middle-bronze-age
#16
Margaret A Judd, Jessica L Walker, Alicia Ventresca Miller, Dmitry Razhev, Andrey V Epimakhov, Bryan K Hanks
OBJECTIVES: We tested the hypothesis that the purported unstable climate in the South Urals region during the Middle Bronze Age (MBA) resulted in health instability and social stress as evidenced by skeletal response. METHODS: The skeletal sample (n = 99) derived from Kamennyi Ambar 5 (KA-5), a MBA kurgan cemetery (2040-1730 cal. BCE, 2 sigma) associated with the Sintashta culture. Skeletal stress indicators assessed included cribra orbitalia, porotic hyperostosis, dental enamel hypoplasia, and tibia periosteal new bone growth...
April 19, 2018: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/29672540/the-impact-of-attachment-distress-on-affect-centered-mentalization-an-experimental-study-in-psychosomatic-patients-and-healthy-adults
#17
Anna S Herrmann, Manfred E Beutel, Katharina Gerzymisch, Richard D Lane, Janine Pastore-Molitor, Jörg Wiltink, Rüdiger Zwerenz, Mita Banerjee, Claudia Subic-Wrana
INTRODUCTION: We investigated the impact of attachment distress on affect-centered mentalization in a clinical and a non-clinical sample, comparing mentalization in a baseline condition to mentalization under a condition of attachment distress. METHODS: The sample consisted of 127 adults who underwent inpatient psychosomatic treatment, and 34 mentally healthy adults. Affect-centered mentalization was assessed by analyzing participants' narratives on interpersonal situations in a baseline condition with the Levels of Emotional Awareness Scale (LEAS), and an experimental condition inducing attachment distress with the Adult Attachment Projective Picture System (AAP)...
2018: PloS One
https://www.readbyqxmd.com/read/29672106/mmpi-2-rf-characteristics-of-veterans-seeking-treatment-for-military-sexual-trauma
#18
Eliza S McManus, Lisa-Ann J Cuccurullo, Madeline Uddo, C Laurel Franklin
Military sexual trauma (MST) is defined as experiences of sexual assault or repeated, threatening, harassment during military service. MST events may not qualify within posttraumatic stress disorder (PTSD) Criterion A, making symptoms associated with MST unique from trauma-related disorders. Little research has been done to understand those presenting for MST treatment. Thus, this article provides Minnesota Multiphasic Personality Inventory 2-Restructured Form (MMPI-2-RF) scores of 33 U.S. veterans who experienced MST in an effort to better understand psychological and personality characteristics of this important and unique group of veterans...
April 2018: Psychological Assessment
https://www.readbyqxmd.com/read/29670226/analysis-for-patient-survival-after-open-abdomen-for-torso-trauma-and-the-impact-of-achieving-primary-fascial-closure-a-single-center-experience
#19
Yu-Pao Hsu, Yon-Cheong Wong, Chih-Yuan Fu, Shang-Yu Wang, Chien-Hung Liao, Chun-Hsiang Ou Yang, Kuo-Ching Yuan
Open abdomen indicates the abdominal fascia is unclosed to abbreviate surgery and to reduce physiological stress. However, complications and difficulties in patient care are often encountered after operation. During May 2008 to March 2013, we performed a prospective protocol-directed observation study regarding open abdomen use in trauma patients. Bogota bag is the temporary abdomen closure initially but negative pressure dressing is used later. A goal-directed ICU care is applied and primary fascial closure is the primary endpoint...
April 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29669612/prehospital-blood-product-administration-opportunities-in-ground-transport-als-ems-a-descriptive-study
#20
Felicia M Mix, Martin D Zielinski, Lucas A Myers, Kathy S Berns, Anurahda Luke, James R Stubbs, Scott P Zietlow, Donald H Jenkins, Matthew D Sztajnkrycer
IntroductionHemorrhage remains the major cause of preventable death after trauma. Recent data suggest that earlier blood product administration may improve outcomes. The purpose of this study was to determine whether opportunities exist for blood product transfusion by ground Emergency Medical Services (EMS). METHODS: This was a single EMS agency retrospective study of ground and helicopter responses from January 1, 2011 through December 31, 2015 for adult trauma patients transported from the scene of injury who met predetermined hemodynamic (HD) parameters for potential transfusion (heart rate [HR]≥120 and/or systolic blood pressure [SBP]≤90)...
April 19, 2018: Prehospital and Disaster Medicine
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