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https://www.readbyqxmd.com/read/28231667/-association-between-body-mass-index-and-both-total-and-cause-specific-mortality-in-china-findings-from-data-through-the-china-kadoorie-biobank
#1
L X Wang, M Y Fan, C Q Yu, Y Guo, Z Bian, Y L Tan, P Pei, J S Chen, J Lyu, L M Li
Objective: To evaluate the associations between body mass index (BMI) and both total and cause-specific mortality. Methods: After excluding participants with heart disease, stroke, cancer, chronic obstructive pulmonary disease, and diabetes at baseline study, 428 593 participants aged 30-79 in the China Kadoorie Biobank study were chosen for this study. Participants were categorized into 9 groups according to their BMI status. Cox regression analysis was used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) of mortality on BMI...
February 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28231576/molecular-markers-involved-in-tumorigenesis-of-thyroid-carcinoma-focus-on-aggressive-histotypes
#2
Gustavo C Penna, Fernanda Vaisman, Mario Vaisman, Manuel Sobrinho-Simões, Paula Soares
Thyroid cancer derived from follicular cells (TCDFC) comprises well-differentiated (papillary and follicular) carcinoma, poorly differentiated carcinoma, and anaplastic carcinoma. Papillary thyroid carcinoma is the most common endocrine cancer, and its incidence is steadily increasing. Lethality and aggressiveness of TCDFC is inversely correlated with differentiation degree. In this review, an emphasis has been put on molecular markers involved in tumorigenesis of thyroid carcinoma with a focus on aggressive histotypes and the role of such biomarkers in predicting thyroid cancer outcome...
February 24, 2017: Cytogenetic and Genome Research
https://www.readbyqxmd.com/read/28231249/low-host-specificity-and-abundance-of-frugivorous-lepidoptera-in-the-lowland-rain-forests-of-papua-new-guinea
#3
Katerina Sam, Richard Ctvrtecka, Scott E Miller, Margaret E Rosati, Kenneth Molem, Kipiro Damas, Bradley Gewa, Vojtech Novotny
We studied a community of frugivorous Lepidoptera in the lowland rainforest of Papua New Guinea. Rearing revealed 122 species represented by 1,720 individuals from 326 woody plant species. Only fruits from 52% (171) of the plant species sampled were attacked. On average, Lepidoptera were reared from 1 in 89 fruits and a kilogram of fruit was attacked by 1.01 individuals. Host specificity of Lepidoptera was notably low: 69% (33) of species attacked plants from >1 family, 8% (4) fed on single family, 6% (3) on single genus and 17% (8) were monophagous...
2017: PloS One
https://www.readbyqxmd.com/read/28231030/safety-of-patient-mobilization-and-rehabilitation-in-the-icu-systematic-review-with-meta-analysis
#4
Peter Nydahl, Thiti Sricharoenchai, Saurabh Chandra, Firuzan Sari Kundt, Minxuan Huang, Magdalena Fischill, Dale M Needham
BACKGROUND: Early mobilization and rehabilitation of patients in intensive care units (ICU) may improve physical function, and reduce the duration of delirium, mechanical ventilation and ICU length of stay. However, safety concerns are an important barrier to widespread implementation. OBJECTIVE: To synthesize safety data regarding patient mobilization and rehabilitation in the ICU, including falls, removal of endotracheal tubes (ETT), removal or dysfunction of intravascular catheters, removal of other catheters/tubes, cardiac arrest, hemodynamic changes and desaturation...
February 23, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28230175/cardiovascular-disease-in-africa-epidemiological-profile-and-challenges
#5
REVIEW
Ashley K Keates, Ana O Mocumbi, Mpiko Ntsekhe, Karen Sliwa, Simon Stewart
From a global perspective, the large and diverse African population is disproportionately affected by cardiovascular disease (CVD). The historical balance between communicable and noncommunicable pathways to CVD in different African regions is dependent on external factors over the life course and at a societal level. The future risk of noncommunicable forms of CVD (predominantly driven by increased rates of hypertension, smoking, and obesity) is a growing public health concern. The incidence of previously rare forms of CVD such as coronary artery disease will increase, in concert with historically prevalent forms of disease, such as rheumatic heart disease, that are yet to be optimally prevented or treated...
February 23, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28229901/what-is-the-association-between-left-ventricular-diastolic-dysfunction-and-6-minute-walk-test-in-hypertensive-patients
#6
El-Sayed M Farag, Mohammad M Al-Daydamony, Marwa M Gad
Heart failure (HF) is a major health problem. Hypertension is an important cause of HF. Most hypertensive patients have some degree of left ventricular (LV) diastolic dysfunction. The 6-minute walk test (6MWT) provides objective data about the exercise tolerance. We aimed to find the association between the degree of LV diastolic dysfunction and the functional capacity assessed by 6MWT in hypertensive patients. The study included 200 asymptomatic hypertensive patients. All patients had undergone full history taking, complete clinical examination, electrocardiography, echocardiography for assessment of LV dimensions, systolic and diastolic dysfunction, and 6MWT...
January 28, 2017: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/28229341/assessment-of-cetuximab-induced-infusion-reactions-and-administration-rechallenge-at-an-academic-medical-center
#7
Ellen Burke, Michelle Rockey, Dennis Grauer, Dave Henry, Prakash Neupane
Cetuximab is approved for treatment of squamous cell carcinoma of the head and neck (SCCHN). Cetuximab is generally well tolerated, but does carry a black box warning for infusion reactions (IRs). Incidence of IR in clinical trials was 15-20% for all grades and 3-5% for grades III-IV. Retrospective studies reported a higher incidence of all grade IRs and grades III-IV IR in areas of the Southeastern United States. Information regarding rechallenge doses after an IR has not been well described. At our institution, we frequently rechallenge on the same day after an initial IR...
April 2017: Medical Oncology
https://www.readbyqxmd.com/read/28229301/safety-and-efficacy-of-postoperative-pharmacologic-thromboprophylaxis-with-enoxaparin-after-pancreatic-surgery
#8
Hajime Imamura, Tomohiko Adachi, Amane Kitasato, Takayuki Tanaka, Akihiko Soyama, Masaaki Hidaka, Fumihiko Fujita, Mitsuhisa Takatsuki, Tamotsu Kuroki, Susumu Eguchi
PURPOSE: Pharmacologic thromboprophylaxis is recommended for preventing pulmonary embolism according to some abdominal surgery guidelines. However, few reports have so far described pharmacologic thromboprophylaxis after pancreatic surgery. In addition, concern remains regarding postoperative bleeding due to pharmacologic thromboprophylaxis. We investigated the safety and efficacy of enoxaparin, a low-molecular-weight heparin, as postoperative pharmacologic thromboprophylaxis after pancreatic surgery...
February 22, 2017: Surgery Today
https://www.readbyqxmd.com/read/28229175/survival-prediction-of-trauma-patients-a-study-on-us-national-trauma-data-bank
#9
I Sefrioui, R Amadini, J Mauro, A El Fallahi, M Gabbrielli
BACKGROUND: Exceptional circumstances like major incidents or natural disasters may cause a huge number of victims that might not be immediately and simultaneously saved. In these cases it is important to define priorities avoiding to waste time and resources for not savable victims. Trauma and Injury Severity Score (TRISS) methodology is the well-known and standard system usually used by practitioners to predict the survival probability of trauma patients. However, practitioners have noted that the accuracy of TRISS predictions is unacceptable especially for severely injured patients...
February 22, 2017: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/28229076/locoregional-therapies-of-cholangiocarcinoma
#10
REVIEW
Christof M Sommer, Hans U Kauczor, Philippe L Pereira
BACKGROUND: Cholangiocarcinoma (CC) is the second most primary liver malignancy with increasing incidence in Western countries. Currently, surgical R0 resection is regarded as the only potentially curative treatment. The results of systemic chemotherapy and best supportive care (BSC) in patients with metastatic disease are often disappointing in regard to toxicity, oncologic efficacy, and overall survival. In current practice, the use of different locoregional therapies is increasingly more accepted...
December 2016: Visceral Medicine
https://www.readbyqxmd.com/read/28229073/epidemiology-and-risk-factors-of-cholangiocarcinoma
#11
Martha M Kirstein, Arndt Vogel
BACKGROUND: Cholangiocarcinoma (CCA) is the second most common primary liver cancer, being characterized by its late diagnosis and fatal outcome. Recent epidemiological reports indicate an increasing worldwide incidence of intrahepatic CCA but a decreasing incidence of extrahepatic CCA. METHODS: In this review, we present an overview of the incidence and epidemiology of CCA and possible strategies for screening and surveillance. RESULTS: Efficient strategies for the screening and surveillance of CCA have not been established so far...
December 2016: Visceral Medicine
https://www.readbyqxmd.com/read/28228733/maturation-of-airway-defensive-reflexes-is-related-to-development-of-feeding-behavior-during-growth-in-rabbits
#12
Laurianne Coutier-Marie, Iulia Ioan, Claude Bonabel, Bruno Demoulin, Anne-Laure Leblanc, Ludivine Debitu, Cyril Schweitzer, François Marchal, Silvia Demoulin-Alexikova
Introduction: Cough and expiration reflex are major lower airway defense mechanisms that have not been studied throughout development in relation with the feeding behavior. Aim: To describe airway defense reflexes evoked by mechanical stimulation of the trachea in developing rabbit pups. Material and Methods: Sixty one pups were allocated to 3 groups according to their feeding behavior: suckling (n = 22), weanling (n = 21) and weaning (n = 18) group. The incidence and sensitivity of defense reflexes triggered by mechanical tracheal stimulation were studied in anesthetized and tracheotomized animals...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28228646/readability-credibility-and-quality-of-patient-information-for-hypogonadism-and-testosterone-replacement-therapy-on-the-internet
#13
J A McBride, C C Carson, R M Coward
The incidence of hypogonadism and use of testosterone replacement therapy (TRT) are rising, while data evaluating the complexity and quality of health-care information available to patients on the Internet for hypogonadism or TRT are lacking. This study focuses on characterizing the readability, credibility and quality of patient-centered information for hypogonadism on the Internet. A Google search was performed to identify top-ranked websites offering patient-centered information on hypogonadism and TRT. Readability was quantified by reading grade level using several validated instruments...
February 23, 2017: International Journal of Impotence Research
https://www.readbyqxmd.com/read/28228499/neonatal-morbidity-and-1-year-survival-of-extremely-preterm-infants
#14
Hans Jorgen Stensvold, Claus Klingenberg, Ragnhild Stoen, Dag Moster, Kristin Braekke, Hans Jorgen Guthe, Henriette Astrup, Siren Rettedal, Morten Gronn, Arild E Ronnestad
OBJECTIVE: To determine 1-year survival and major neonatal morbidities (intracranial hemorrhage grade >2, cystic periventricular leukomalacia, retinopathy of prematurity grade >2, necrotizing enterocolitis, severe bronchopulmonary dysplasia) among extremely preterm infants in Norway in 2013-2014, and to compare the results to the first Norwegian Extreme Prematurity Study 1999-2000 and similar contemporary European population-based studies. METHODS: Population-based study of all infants born at 22 through 26 weeks' gestation in Norway in 2013-2014...
February 22, 2017: Pediatrics
https://www.readbyqxmd.com/read/28228467/gender-differences-in-clinical-presentation-and-1-year-outcomes-in-atrial-fibrillation
#15
Renate B Schnabel, Ladislav Pecen, Francisco M Ojeda, Markus Lucerna, Nargiz Rzayeva, Stefan Blankenberg, Harald Darius, Dipak Kotecha, Raffaele De Caterina, Paulus Kirchhof
OBJECTIVES: Our objective was to examine gender differences in clinical presentation, management and prognosis of atrial fibrillation (AF) in a contemporary cohort. METHODS: In 6412 patients, 39.7% women, of the PREvention oF thromboembolic events - European Registry in Atrial Fibrillation, we examined gender differences in symptoms, risk factors, therapies and 1-year incidence of adverse outcomes. RESULTS: Men with AF were on average younger than women (mean±SD: 70...
February 22, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28228427/myocardial-infarction-risk-after-discontinuation-of-thienopyridine-therapy-in-the-randomized-dapt-study
#16
Ada C Stefanescu Schmidt, Dean J Kereiakes, Donald E Cutlip, Robert W Yeh, Ralph B D'Agostino, Joseph M Massaro, Wen-Hua Hsieh, Laura Mauri
Background -Thienopyridine plus aspirin beyond one year after coronary stenting (PCI) reduces myocardial infarction (MI) risk and increases bleeding risk compared with aspirin alone. The hazard associated with late thienopyridine discontinuation and risk factors for MI after discontinuation are poorly defined. Methods -In the Dual Antiplatelet Therapy (DAPT) Study, after PCI and 12 months of thienopyridine (clopidogrel or prasugrel) plus aspirin, eligible patients remained on aspirin and were randomized to continued thienopyridine vs...
February 22, 2017: Circulation
https://www.readbyqxmd.com/read/28228294/cardiac-resynchronization-therapy-in-patients-with-mild-heart-failure-is-a-reversal-therapy
#17
REVIEW
Sadegh Ali-Hassan-Sayegh, Seyed Jalil Mirhosseini, Ali Akbar Karimi-Bondarabadi, Azadeh Sahidzadeh, Parisa Mahdavi, Mahbube Tahernejad, Safieyehsadat Heydari, Alexander Weymann, Mohamed Zeriouh, Anton Sabashnikov, Aron-Frederik Popov
This systematic review with meta-analysis sought to determine the efficacy, safety of implantation of cardiac resynchronization therapy (CRT) in mild heart failure (HF). Medline, Embase, Elsevier, and Sciences online database as well as Google scholar literature were used for selecting appropriate studies with randomized controlled design. The literature search of all major databases retrieved 2035 studies. After screening, a total of 10 trials were identified that reported outcomes of interest. Pooled analysis was performed on left ventricular (LV) ejection fraction (P<0...
January 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/28228154/circulating-species-of-leishmania-at-microclimate-area-of-boulemane-province-morocco-impact-of-environmental-and-human-factors
#18
Asmae Hmamouch, Mahmoud Mohamed El Alem, Maryam Hakkour, Fatima Amarir, Hassan Daghbach, Khalid Habbari, Hajiba Fellah, Khadija Bekhti, Faiza Sebti
BACKGROUND: Cutaneous leishmaniasis (CL) is widely distributed in Morocco where its geographical range and incidence are related to environmental factors. This study aimed to examine the impact of several factors on the distribution of CL in Boulemane Province, which is characterized by several microclimates, and to identify the Leishmania species circulating in these areas. METHODS: Ordinary least squares regression (OLSR) analysis was performed to study the impact of poverty, vulnerability, population density, urbanization and bioclimatic factors on the distribution of CL in this province...
February 22, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28228055/increased-enoxaparin-dosing-for-venous-thromboembolism-prophylaxis-in-general-trauma-patients
#19
Cheri K Walker, Elizabeth A Sandmann, Taylor J Horyna, Mark A Gales
OBJECTIVE: To review the evidence regarding increased enoxaparin dosing for venous thromboembolism (VTE) prophylaxis in the general trauma patient population. DATA SOURCES: A search of MEDLINE databases (1946 to October 2016) was conducted using the search terms enoxaparin, thromboembolism prophylaxis, venous thromboembolism, trauma, anti-factor Xa, and weight-based dosing. Additional references were identified from a review of literature citations. STUDY SELECTION AND DATA EXTRACTION: Search results were limited to English-language studies conducted in humans...
April 2017: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/28227775/3d-anatomical-reconstruction-of-human-cardiac-conduction-system-and-simulation-of-bundle-branch-block-after-tavi-procedure
#20
Andrew J Atkinson, Sanjay R Kharche, Michael G Bateman, Paul A Iaizzo, Halina Dobrzynski, Andrew J Atkinson, Sanjay R Kharche, Michael G Bateman, Paul A Iaizzo, Halina Dobrzynski, Andrew J Atkinson, Paul A Iaizzo, Halina Dobrzynski, Sanjay R Kharche, Michael G Bateman
The cardiac conduction system (CCS) is responsible for the initiation and propagation of action potentials through the heart ensuring efficient pumping of blood. Understanding the anatomy of the CCS and its relationship with other major cardiac components is important to help understand arrhythmias and how certain procedures may increase the incidence of arrhythmias developing. We sectioned a whole human heart and performed Masson's trichrome histology in order to identify the components of the CCS. The histology images were used to construct a 3D anatomical model...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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