keyword
MENU ▼
Read by QxMD icon Read
search

Devinsky

keyword
https://www.readbyqxmd.com/read/28074282/unique-findings-of-subependymal-giant-cell-astrocytoma-within-cortical-tubers-in-patients-with-tuberous-sclerosis-complex-a-histopathological-evaluation
#1
Joel S Katz, Hyman Frankel, Tracy Ma, David Zagzag, Benjamin Liechty, Bruria Ben Zeev, Michal Tzadok, Orrin Devinsky, Howard L Weiner, Jonathan Roth
INTRODUCTION: Tuberous sclerosis is associated with three central nervous system pathologies: cortical/subcortical tubers, subependymal nodules (SENs), and subependymal giant cell astrocytomas (SEGAs). Tubers are associated with epilepsy, which is often medication-resistant and often leads to resective surgery. Recently, mammalian target of rapamycin inhibitors (mTORi) have been shown to be effective reducing seizure burden in some patients with tuberous sclerosis complex (TSC)-related refractory epilepsy...
January 10, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28053858/a-major-miss-in-prognostication-after-cardiac-arrest-burst-suppression-and-brain-healing
#2
Danielle A Becker, Nicholas D Schiff, Lance B Becker, Manisha G Holmes, Joseph J Fins, James M Horowitz, Orrin Devinsky
We report a case with therapeutic hypothermia after cardiac arrest where meaningful recovery far exceeded anticipated negative endpoints following cardiac arrest with loss of brainstem reflexes and subsequent status epilepticus. This man survived and recovered after an out-of-hospital cardiac arrest followed by a 6-week coma with absent motor responses and 5 weeks of burst suppression. Standard criteria suggested no chance of recovery. His recovery may relate to the effect of burst-suppression on EEG to rescue neurons near neuronal cell death...
2017: Epilepsy & Behavior Case Reports
https://www.readbyqxmd.com/read/27999327/antimicrobial-activity-and-urease-inhibition-of-schiff-bases-derived-from-isoniazid-and-fluorinated-benzaldehydes-and-of-their-copper-ii-complexes
#3
Ladislav Habala, Samuel Varényi, Andrea Bilková, Peter Herich, Jindra Valentová, Jozef Kožíšek, Ferdinand Devínsky
In order to evaluate the influence of substitution on biological properties of Schiff bases and their metal complexes, a series of differently substituted fluorine-containing Schiff bases starting from the drug isoniazid (isonicotinylhydrazide) were prepared and their structures were established by single-crystal X-ray diffraction. Also, four copper(II) complexes of these Schiff bases were synthesized. The prepared compounds were evaluated for their antimicrobial activity and urease inhibition. Two of the Schiff bases exerted activity against C...
December 17, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27991184/parahippocampal-and-entorhinal-resection-extent-predicts-verbal-memory-decline-in-an-epilepsy-surgery-cohort
#4
Anil Lu, Thomas Thesen, William Barr, Chris Morrison, Patricia Dugan, Xiuyuan Wang, Michael Meager, Werner Doyle, Ruben Kuzniecky, Orrin Devinsky, Karen Blackmon
The differential contribution of medial-temporal lobe regions to verbal declarative memory is debated within the neuroscience, neuropsychology, and cognitive psychology communities. We evaluate whether the extent of surgical resection within medial-temporal regions predicts longitudinal verbal learning and memory outcomes. This single-center retrospective observational study involved patients with refractory temporal lobe epilepsy undergoing unilateral anterior temporal lobe resection from 2007 to 2015. Thirty-two participants with Engel Classes 1 and 2 outcomes were included (14 left, 18 right) and followed for a mean of 2...
December 19, 2016: Journal of Cognitive Neuroscience
https://www.readbyqxmd.com/read/27989258/musical-hallucinations-a-brief-review-of-functional-neuroimaging-findings
#5
Francesco Bernardini, Luigi Attademo, Karen Blackmon, Orrin Devinsky
Musical hallucinations are uncommon phenomena characterized by intrusive and frequently distressful auditory musical percepts without an external source, often associated with hypoacusis, psychiatric illness, focal brain lesion, epilepsy, and intoxication/pharmacology. Their physiological basis is thought to involve diverse mechanisms, including "release" from normal sensory or inhibitory inputs as well as stimulation during seizures, or they can be produced by functional or structural disorders in diverse cortical and subcortical areas...
December 19, 2016: CNS Spectrums
https://www.readbyqxmd.com/read/27941789/manipulating-stored-phonological-input-during-verbal-working-memory
#6
Gregory B Cogan, Asha Iyer, Lucia Melloni, Thomas Thesen, Daniel Friedman, Werner Doyle, Orrin Devinsky, Bijan Pesaran
Verbal working memory (vWM) involves storing and manipulating information in phonological sensory input. An influential theory of vWM proposes that manipulation is carried out by a central executive while storage is performed by two interacting systems: a phonological input buffer that captures sound-based information and an articulatory rehearsal system that controls speech motor output. Whether, when and how neural activity in the brain encodes these components remains unknown. Here we read out the contents of vWM from neural activity in human subjects as they manipulated stored speech sounds...
December 12, 2016: Nature Neuroscience
https://www.readbyqxmd.com/read/27668180/a-case-report-on-the-efficacy-of-vigabatrin-analogue-1s-3s-3-amino-4-difluoromethylenyl-1-cyclopentanoic-acid-cpp-115-in-a-patient-with-infantile-spasms
#7
Kyra Doumlele, Erin Conway, Julie Hedlund, Patricia Tolete, Orrin Devinsky
West Syndrome is characterized by infantile spasms, a hypsarrhythmic electroencephalogram (EEG) pattern, and a poor neurodevelopmental prognosis. First-line treatments include adrenocorticotrophic hormone (ACTH) and vigabatrin, but adverse effects often limit their use. CPP-115 is a high-affinity vigabatrin analogue developed to increase therapeutic potency and to limit retinal toxicity. Here, we present a child treated with CPP-115 through an investigational new drug protocol who experienced a marked reduction of seizures with no evidence of retinal dysfunction...
2016: Epilepsy & Behavior Case Reports
https://www.readbyqxmd.com/read/27638923/sudden-neurologic-death-masquerading-as-out-of-hospital-sudden-cardiac-death
#8
Anthony S Kim, Ellen Moffatt, Philip C Ursell, Orrin Devinsky, Jeffrey Olgin, Zian H Tseng
OBJECTIVE: To characterize the frequency of and risk factors for out-of-hospital sudden neurologic deaths. METHODS: During the initial 25 months (February 1, 2011-March 1, 2013) of the San Francisco Postmortem Systematic Investigation of Sudden Cardiac Death Study, we captured incident WHO criteria sudden cardiac deaths (SCDs) through active surveillance of consecutive out-of-hospital deaths, which must be reported to the medical examiner by law. All cases were referred for full autopsy with detailed examination of the heart and cranial vault, toxicology, and histology...
October 18, 2016: Neurology
https://www.readbyqxmd.com/read/27571159/sudden-unexpected-death-in-epilepsy-epidemiology-mechanisms-and-prevention
#9
REVIEW
Orrin Devinsky, Dale C Hesdorffer, David J Thurman, Samden Lhatoo, George Richerson
Sudden unexpected death in epilepsy (SUDEP) can affect individuals of any age, but is most common in younger adults (aged 20-45 years). Generalised tonic-clonic seizures are the greatest risk factor for SUDEP; most often, SUDEP occurs after this type of seizure in bed during sleep hours and the person is found in a prone position. SUDEP excludes other forms of seizure-related sudden death that might be mechanistically related (eg, death after single febrile, unprovoked seizures, or status epilepticus). Typically, postictal apnoea and bradycardia progress to asystole and death...
September 2016: Lancet Neurology
https://www.readbyqxmd.com/read/27568816/de-novo-loss-of-function-mutations-in-kiaa2022-are-associated-with-epilepsy-and-neurodevelopmental-delay-in-females
#10
Rachel Webster, Megan T Cho, Kyle Retterer, Francisca Millan, Catherine Nowak, Jessica Douglas, Ayesha Ahmad, Gerald V Raymond, Maria R Johnson, Aurora Pujol, Amber Begtrup, Dianalee McKnight, Orrin Devinsky, Wendy K Chung
Intellectual disability (ID) affects about 3% of the population and has a male gender bias. Of at least 700 genes currently linked to ID, more than 100 have been identified on the X chromosome, including KIAA2022. KIAA2022 is located on Xq13.3 and is expressed in the developing brain. The protein product of KIAA2022, X-linked Intellectual Disability Protein Related to Neurite Extension (XPN), is developmentally regulated and is involved in neuronal migration and cell adhesion. The clinical manifestations of loss-of-function KIAA2022 mutations have been described previously in fifteen males, born from unaffected carrier mothers, but few females...
August 28, 2016: Clinical Genetics
https://www.readbyqxmd.com/read/27552905/experimental-and-in-silico-investigations-of-organic-phosphates-and-phosphonates-sorption-on-polymer-ceramic-monolithic-materials-and-hydroxyapatite
#11
Monika Pietrzyńska, Joanna Zembrzuska, Rafał Tomczak, Jakub Mikołajczyk, Danuta Rusińska-Roszak, Adam Voelkel, Tomasz Buchwald, Josef Jampílek, Miloš Lukáč, Ferdinand Devínsky
A method based on experimental and in silico evaluations for investigating interactions of organic phosphates and phosphonates with hydroxyapatite was developed. This quick and easy method is used for determination of differences among organophosphorus compounds of various structures in their mineral binding affinities. Empirical sorption evaluation was carried out using liquid chromatography with tandem mass spectrometry or UV-VIS spectroscopy. Raman spectroscopy was used to confirm sorption of organic phosphates and phosphonates on hydroxyapatite...
October 10, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27490530/preparation-of-hydrochlorothiazide-nanoparticles-for-solubility-enhancement
#12
Eliska Vaculikova, Aneta Cernikova, Daniela Placha, Martin Pisarcik, Pavlina Peikertova, Katerina Dedkova, Ferdinand Devinsky, Josef Jampilek
Nanoparticles can be considered as a useful tool for improving properties of poorly soluble active ingredients. Hydrochlorothiazide (Class IV of the Biopharmaceutical Classification System) was chosen as a model compound. Antisolvent precipitation-solvent evaporation and emulsion solvent evaporation methods were used for preparation of 18 samples containing hydrochlorothiazide nanoparticles. Water solutions of surfactants sodium dodecyl sulfate, Tween 80 and carboxymethyl dextran were used in mass concentrations of 1%, 3% and 5%...
August 2, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27405726/network-analysis-on-predicting-mean-diffusivity-change-at-group-level-in-temporal-lobe-epilepsy
#13
Farras Abdelnour, Ashish Raj, Orrin Devinsky, Thomas Thesen
The two most common types of temporal lobe epilepsy are medial temporal sclerosis (TLE-MTS) epilepsy and MRI-normal temporal lobe epilepsy (TLE-no). TLE-MTS is specified by its stereotyped focus and spread pattern of neuronal damage, with pronounced neuronal loss in the hippocampus. TLE-no exhibits normal-appearing hippocampus and more widespread neuronal loss. In both cases, neuronal loss spread appears to be constrained by the white matter connections. Both varieties of epilepsy reveal pathological abnormalities in increased mean diffusivity (MD)...
September 7, 2016: Brain Connectivity
https://www.readbyqxmd.com/read/27399643/the-brain-that-changed-neurology-broca-s-1861-case-of-aphasia
#14
Orrin Devinsky, Martin A Samuels
No abstract text is available yet for this article.
September 2016: Annals of Neurology
https://www.readbyqxmd.com/read/27374869/resting-state-functional-mri-distinguishes-temporal-lobe-epilepsy-subtypes
#15
Anny Reyes, Thomas Thesen, Xiuyuan Wang, Daniel Hahn, Daeil Yoo, Ruben Kuzniecky, Orrin Devinsky, Karen Blackmon
OBJECTIVE: We assessed whether presurgical resting state functional magnetic resonance imaging (fMRI) provides information for distinguishing temporal lobe epilepsy (TLE) with mesial temporal sclerosis (TLE-MTS) from TLE without MTS (TLE-noMTS). METHODS: Thirty-four patients with TLE and 34 sex-/age-matched controls consented to a research imaging protocol. MTS status was confirmed by histologic evaluation of surgical tissue (TLE-MTS = 16; TLE-noMTS = 18). The fractional amplitude of low-frequency fluctuations (fALFFs) in the blood oxygen level-dependent (BOLD) resting-state fMRI signal, a marker of local metabolic demand at rest, was averaged at five regions of interest (ROIs; hippocampus, amygdala, frontal, occipital, and temporal lobe), along with corresponding volume and cortical thickness estimates...
September 2016: Epilepsia
https://www.readbyqxmd.com/read/27358180/de-novo-mutations-of-kiaa2022-in-females-cause-intellectual-disability-and-intractable-epilepsy
#16
Iris M de Lange, Katherine L Helbig, Sarah Weckhuysen, Rikke S Møller, Milen Velinov, Natalia Dolzhanskaya, Eric Marsh, Ingo Helbig, Orrin Devinsky, Sha Tang, Heather C Mefford, Candace T Myers, Wim van Paesschen, Pasquale Striano, Koen van Gassen, Marjan van Kempen, Carolien G F de Kovel, Juliette Piard, Berge A Minassian, Marjan M Nezarati, André Pessoa, Aurelia Jacquette, Bridget Maher, Simona Balestrini, Sanjay Sisodiya, Marie Therese Abi Warde, Anne De St Martin, Jamel Chelly, Ruben van 't Slot, Lionel Van Maldergem, Eva H Brilstra, Bobby P C Koeleman
BACKGROUND: Mutations in the KIAA2022 gene have been reported in male patients with X-linked intellectual disability, and related female carriers were unaffected. Here, we report 14 female patients who carry a heterozygous de novo KIAA2022 mutation and share a phenotype characterised by intellectual disability and epilepsy. METHODS: Reported females were selected for genetic testing because of substantial developmental problems and/or epilepsy. X-inactivation and expression studies were performed when possible...
June 29, 2016: Journal of Medical Genetics
https://www.readbyqxmd.com/read/27306678/human-parietal-cortex-lesions-impact-the-precision-of-spatial-working-memory
#17
Wayne E Mackey, Orrin Devinsky, Werner K Doyle, John G Golfinos, Clayton E Curtis
The neural mechanisms that support working memory (WM) depend on persistent neural activity. Within topographically organized maps of space in dorsal parietal cortex, spatially selective neural activity persists during WM for location. However, to date, the necessity of these topographic subregions of human parietal cortex for WM remains unknown. To test the causal relationship of these areas to WM, we compared the performance of patients with lesions to topographically organized parietal cortex with those of controls on a memory-guided saccade (MGS) task as well as a visually guided saccade (VGS) task...
September 1, 2016: Journal of Neurophysiology
https://www.readbyqxmd.com/read/27300147/safety-and-efficacy-of-perampanel-in-children-and-adults-with-various-epilepsy-syndromes-a-single-center-postmarketing-study
#18
Kanwaljit Singh, Yash D Shah, Daniel Luciano, Daniel Friedman, Orrin Devinsky, Sanjeev V Kothare
INTRODUCTION: Perampanel is an AMPA receptor antagonist recently approved for the treatment of partial and generalized epilepsies with tonic-clonic seizures as an add-on therapy. METHODS: This single-center postmarketing study retrospectively evaluated the efficacy of perampanel in patients with partial onset and other seizure types, with a special emphasis on its efficacy, safety, and tolerability. RESULTS: Review of medical records revealed that adequate data were available on 101 patients taking perampanel...
August 2016: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/27221596/nonseizure-sudep-sudden-unexpected-death-in-epilepsy-without-preceding-epileptic-seizures
#19
Samden D Lhatoo, Maromi Nei, Manoj Raghavan, Michael Sperling, Bilal Zonjy, Nuria Lacuey, Orrin Devinsky
OBJECTIVE: To describe the phenomenology of monitored sudden unexpected death in epilepsy (SUDEP) occurring in the interictal period where death occurs without a seizure preceding it. METHODS: We report a case series of monitored definite and probable SUDEP where no electroclinical evidence of underlying seizures was found preceding death. RESULTS: Three patients (two definite and one probable) had SUDEP. They had a typical high SUDEP risk profile with longstanding intractable epilepsy and frequent generalized tonic-clonic seizures (GTCS)...
July 2016: Epilepsia
https://www.readbyqxmd.com/read/27218684/mortality-in-isodicentric-chromosome-15-syndrome-the-role-of-sudep
#20
Daniel Friedman, Alison Thaler, Jonathan Thaler, Samhitha Rai, Edwin Cook, Carolyn Schanen, Orrin Devinsky
PURPOSE: To ascertain the cause of mortality and incidence of sudden unexpected death in epilepsy (SUDEP) in patients with supernumerary isodicentric chromosome 15 (idic15). METHODS: Cases were obtained from those reported to the Dup15q Alliance (www.dup15q.org) between April 2006 and June 2012; ~709 families were registered in their database. We performed a case-control study comparing reported SUDEP cases to living patients with epilepsy from the Dup15q Alliance registry who volunteered to be interviewed to examine clinical risk factors...
August 2016: Epilepsy & Behavior: E&B
keyword
keyword
12568
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"