keyword
MENU ▼
Read by QxMD icon Read
search

Txnip

keyword
https://www.readbyqxmd.com/read/28099758/melatonin-alleviates-cadmium-induced-liver-injury-by-inhibiting-the-txnip-nlrp3-inflammasome
#1
Zhengwang Cao, Yiliang Fang, Yonghui Lu, Dunxian Tan, Changhong Du, Yuming Li, Qinlong Ma, Junmei Yu, Mengyan Chen, Chao Zhou, Liping Pei, Lei Zhang, Haiying Ran, Mindi He, Zhengping Yu, Zhou Zhou
Cadmium (Cd) is a persistent environmental and occupational contaminant that accumulates in the liver and induces oxidative stress and inflammation. Melatonin possesses potent hepatoprotective properties against the development and progression of acute and chronic liver injury. Nevertheless, the molecular mechanism underlying the protective effects of melatonin against Cd-induced hepatotoxicity remains obscure. In the present study, we aimed to investigate the effects of melatonin on Cd-induced liver inflammation and hepatocyte death...
January 18, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/28070626/nuclear-receptors-regulate-lipid-metabolism-and-oxidative-stress-markers-in-chondrocytes
#2
Anusha Ratneswaran, Margaret Man-Ger Sun, Holly Dupuis, Cynthia Sawyez, Nica Borradaile, Frank Beier
: Joint homeostasis failure can result in osteoarthritis (OA). Currently, there are no treatments to alter disease progression in OA, but targeting early changes in cellular behavior has great potential. Recent data show that nuclear receptors contribute to the pathogenesis of OA and could be viable therapeutic targets, but their molecular mechanisms in cartilage are incompletely understood. This study examines global changes in gene expression after treatment with agonists for four nuclear receptor implicated in OA (LXR, PPARδ, PPARγ, and RXR)...
January 9, 2017: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/28068647/berberine-an-isoquinoline-alkaloid-suppresses-txnip-mediated-nlrp3-inflammasome-activation-in-msu-crystal-stimulated-raw-264-7-macrophages-through-the-upregulation-of-nrf2-transcription-factor-and-alleviates-msu-crystal-induced-inflammation-in-rats
#3
Palani Dinesh, MahaboobKhan Rasool
The current study was designed to investigate the therapeutic potential of berberine on monosodium urate (MSU) crystal stimulated RAW 264.7 macrophages and in MSU crystal induced rats. Our results indicate that berberine (25, 50 and 75μM) suppressed the levels of pro-inflammatory cytokines (interleukin-1beta (IL-1β) and tumor necrosis factor alpha (TNFα)) and intracellular reactive oxygen species in MSU crystal stimulated RAW 264.7 macrophages. The mRNA expression levels of IL-1β, caspase 1, nucleotide-binding oligomerization domain-like receptor pyrin domain containing 3 (NLRP3), thioredoxin interacting protein (TXNIP) and kelch-like ECH-associated protein 1 (Keap1) were found downregulated with the upregulation of nuclear factor erythroid-2-related factor 2 (Nrf2) transcription factor and its associated anti-oxidant enzymes: Heme oxygenase I (HO-1), superoxide dismutase (SOD1), glutathione peroxidase (GPx), NADPH quinone oxidoreductase-1 (NQO1) and catalase (CAT) in MSU crystal stimulated RAW 264...
January 6, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28064010/vascular-endothelial-cells-senescence-is-associated-with-nod-like-receptor-family-pyrin-domain-containing-3-nlrp3-inflammasome-activation-via-reactive-oxygen-species-ros-thioredoxin-interacting-protein-txnip-pathway
#4
Yanlin Yin, Zhihui Zhou, Weiwei Liu, Qun Chang, Guanqun Sun, Yalei Dai
Endothelial dysfunction caused by endothelial cells senescence and chronic inflammation is tightly linked to the development of cardiovascular diseases. NLRP3 (NOD-like receptor family pyrin domain-containing3) inflammasome plays a central role in inflammatory response that is associated with diverse inflammatory diseases. This study explores the effects and possible mechanisms of NLRP3 inflammasome in endothelial cells senescence. Results show an increment of pro-inflammatory cytokine interleukin (IL) -1β secretion and caspase-1 activation during the senescence of endothelial cells induced by bleomycin...
January 4, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/28056989/induction-of-altered-gene-expression-profiles-in-cultured-bovine-granulosa-cells-at-high-cell-density
#5
Anja Baufeld, Dirk Koczan, Jens Vanselow
BACKGROUND: In previous studies it has been shown that bovine granulosa cells (GC) cultured at a high plating density dramatically change their physiological and molecular characteristics, thus resembling an early stage of luteinization. During the present study, these specific effects on the GC transcriptome were comprehensively analysed to clarify the underlying mechanisms. METHODS: GC were cultured in serum free medium with FSH and IGF-1 stimulation at different initial plating density...
January 5, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28033672/txnip-mediates-the-differential-responses-of-a549-cells-to-sodium-butyrate-and-sodium-4-phenylbutyrate-treatment
#6
Xuefang Jin, Nana Wu, Juji Dai, Qiuxia Li, XiaoQiang Xiao
Sodium butyrate (NaBu) and sodium 4-phenylbutyrate (4PBA) have promising futures in cancer treatment; however, their underlying molecular mechanisms are not clearly understood. Here, we show A549 cell death induced by NaBu and 4PBA are not the same. NaBu treatment induces a significantly higher level of A549 cell death than 4PBA. A gene expression microarray identified more than 5000 transcripts that were altered (>1.5-fold) in NaBu-treated A549 cells, but fewer than 2000 transcripts that were altered in 4PBA...
December 29, 2016: Cancer Medicine
https://www.readbyqxmd.com/read/28030356/transcriptional-immune-response-in-mesenteric-lymph-nodes-in-pigs-with-different-levels-of-resistance-to-ascaris-suum
#7
Per Skallerup, Peter Nejsum, Susanna Cirera, Kerstin Skovgaard, Christian B Pipper, Merete Fredholm, Claus B Jørgensen, Stig M Thamsborg
A single nucleotide polymorphism on chromosome 4 (SNP TXNIP) has been reported to be associated with roundworm (Ascaris suum) burden in pigs. The objective of the present study was to analyse the immune response to A. suum mounted by pigs with genotype AA (n = 24) and AB (n = 23) at the TXNIP locus. The pigs were repeatedly infected with A. suum from eight weeks of age until necropsy eight weeks later. An uninfected control group (AA; n = 5 and AB; n = 5) was also included. At post mortem, we collected mesenteric lymph nodes and measured the expression of 28 selected immune-related genes...
March 1, 2017: Acta Parasitologica
https://www.readbyqxmd.com/read/28029659/knockdown-of-rnf2-induces-cell-cycle-arrest-and-apoptosis-in-prostate-cancer-cells-through-the-upregulation-of-txnip
#8
Ming Wei, Dian Jiao, Donghui Han, Jieheng Wu, Feilong Wei, Guoxu Zheng, Zhangyan Guo, Wenjin Xi, Fa Yang, Pin Xie, Lingling Zhang, An-Gang Yang, He Wang, Weijun Qin, Weihong Wen
RNF2, also known as RING1b or RING2, is identified as the catalytic subunit of polycomb repressive complex 1 (PRC1), which mediates the mono-ubiquitination of histone H2A. RNF2 has been proved to have oncogenic function in many kinds of cancers, but the function of RNF2 in prostate cancer (PCa) has not been evaluated. Here we show that PCa tissues showed higher RNF2 expression than the benign prostatic hyperplasia (BPH) tissues. Knockdown of RNF2 in PCa cells resulted in cell cycle arrest, increased apoptosis and inhibited cell proliferation, and the growth of RNF2 knockdown PCa xenografts were obviously inhibited in nude mice...
December 24, 2016: Oncotarget
https://www.readbyqxmd.com/read/28025459/tgp-attenuates-endoplasmic-reticulum-stress-and-regulates-the-expression-of-thioredoxin-interacting-protein-in-the-kidneys-of-diabetic-rats
#9
Yunxia Shao, Xiangming Qi, Xinxing Xu, Kun Wang, Yonggui Wu, Lingling Xia
Recent evidence suggests that the endoplasmic reticulum stress (ERS)-thioredoxin-interacting protein (TXNIP)-inflammation chain contributes to diabetic renal injury. The aim of the current study was to investigate whether total glucosides of peony (TGP) could inhibit ERS and attenuate up-regulation of TXNIP in the kidneys of rats with streptozotocin-induced diabetes. TGP was orally administered daily at a dose of 50, 100, or 200 mg/kg for 8 weeks. The expression of glucose-regulated protein 78 (GRP78), phospho-protein kinase RNA-like ER kinase (p-PERK), phosphor- eukaryotic translation initiation factor 2α (p-eIF2α), C/EBP-homologous protein (CHOP), and TXNIP was assessed...
December 24, 2016: Bioscience Trends
https://www.readbyqxmd.com/read/28000177/geniposide-accelerates-proteasome-degradation-of-txnip-to-inhibit-insulin-secretion-in-pancreatic-%C3%AE-cells
#10
C Y Liu, Y N Hao, F Yin, Y L Zhang, J H Liu
PURPOSE: To analyze the role of geniposide in the protein degradation of Txnip and to determine the impact of Txnip on geniposide-regulated GSIS in pancreatic INS-1 cells. METHODS: The content of Txnip protein was measured by western blot; insulin content and glucose uptake were determined by ELISA; and knockdown of Txnip was the method of RNA interference. RESULTS: Glucose induces a rapid increase in Txnip protein, and geniposide accelerates the degradation of Txnip via proteasome pathway in the presence of high glucose (25 mM) in INS-1 pancreatic β-cells...
December 20, 2016: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/27989964/histone-acetylation-of-glucose-induced-thioredoxin-interacting-protein-gene-expression-in-pancreatic-islets
#11
Pradeep Bompada, David Atac, Cheng Luan, Robin Andersson, Judit Domènech Omella, Emilia Ottosson Laakso, Jason Wright, Leif Groop, Yang De Marinis
Thioredoxin-interacting protein (TXNIP) has been shown to be associated with glucose-induced deterioration of pancreatic beta cell function in diabetes. However, whether epigenetic mechanisms contribute to the regulation of TXNIP gene expression by glucose is not clear. Here we studied how glucose exerts its effect on TXNIP gene expression via modulation of histone acetylation marks. To achieve this, we applied clustered regularly interspaced short palindromic repeats/Cas9 (CRISPR/Cas9) to knock out histone acetyltransferase (HAT) p300 in a rat pancreatic beta cell line INS1 832/13...
October 29, 2016: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/27936392/rutin-protects-endothelial-dysfunction-by-disturbing-nox4-and-ros-sensitive-nlrp3-inflammasome
#12
Wei Wang, Qiu-Hong Wu, Yong Sui, Yan Wang, Xin Qiu
High glucose induced endothelial dysfunction is blamed for initiation of vascular complication in Type 2 diabetes mellitus. Rutin has been described in possessing comprehensive pharmacological activities, but the mechanism involved in endothelial protection through regulating oxidative stress and damage is still ambiguous. In the present study, rutin was evaluated in high glucose stimulated human umbilical vein endothelial cells (HUVECs) and high glucose diet-treated SD rats were applied to explored the molecular mechanism in rutin counteracting oxidative stress and damage...
December 6, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27929088/thioredoxin-interacting-protein-regulates-haematopoietic-stem-cell-ageing-and-rejuvenation-by-inhibiting-p38-kinase-activity
#13
Haiyoung Jung, Dong Oh Kim, Jae-Eun Byun, Won Sam Kim, Mi Jeong Kim, Hae Young Song, Young Kwan Kim, Du-Kyeong Kang, Young-Jun Park, Tae-Don Kim, Suk Ran Yoon, Hee Gu Lee, Eun-Ji Choi, Sang-Hyun Min, Inpyo Choi
Ageing is a natural process in living organisms throughout their lifetime, and most elderly people suffer from ageing-associated diseases. One suggested way to tackle such diseases is to rejuvenate stem cells, which also undergo ageing. Here we report that the thioredoxin-interacting protein (TXNIP)-p38 mitogen-activated protein kinase (p38) axis regulates the ageing of haematopoietic stem cells (HSCs), by causing a higher frequency of long-term HSCs, lineage skewing, a decrease in engraftment, an increase in reactive oxygen species and loss of Cdc42 polarity...
December 8, 2016: Nature Communications
https://www.readbyqxmd.com/read/27898405/n-acetyl-cysteine-attenuated-the-deleterious-effects-of-advanced-glycation-end-products-on-the-kidney-of-non-diabetic-rats
#14
Karina Thieme, Karolline S Da Silva, Nelly T Fabre, Sergio Catanozi, Maria Beatriz Monteiro, Daniele Pereira Santos-Bezerra, Juliana Martins Costa-Pessoa, Maria Oliveira-Souza, Ubiratan F Machado, Marisa Passarelli, Maria Lucia Correa-Giannella
AIM: To assess the renal effects of chronic exposure to advanced glycation end-products (AGEs) in the absence of diabetes and the potential impact of concomitant treatment with the antioxidant N-acetyl cysteine (NAC). METHODS: Wistar rats received intraperitoneally 20 mg/kg/day of albumin modified (AlbAGE) or not (AlbC) by advanced glycation for 12 weeks and oral NAC (600mg/L; AlbAGE+NAC and AlbC+NAC, respectively). Biochemical, urinary and renal morphological analyses; carboxymethyl-lysine (CML, an AGE), CD68 (macrophage infiltration), and 4-hydroxynonenal (4-HNE, marker of oxidative stress) immunostaining; intrarenal mRNA expression of genes belonging to pathways related to AGEs (Ager, Ddost, Nfkb1), renin-angiotensin system (Agt, Ren, Ace), fibrosis (Tgfb1, Col4a1), oxidative stress (Nox4, Txnip), and apoptosis (Bax, Bcl2); and reactive oxidative species (ROS) content were performed...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27867451/thioredoxin-interacting-protein-mediates-nlrp3-inflammasome-activation-involved-in-the-susceptibility-to-ischemic-acute-kidney-injury-in-diabetes
#15
Ye Da Xiao, Ya Yi Huang, Hua Xin Wang, Yang Wu, Yan Leng, Min Liu, Qian Sun, Zhong-Yuan Xia
Kidney in diabetic state is more sensitive to ischemic acute kidney injury (AKI). However, the underlying mechanisms remain unclear. Herein, we examined the impact of diabetes mellitus on thioredoxin-interacting protein (TXNIP) expression and whether mediated NLRP3 activation was associated with renal ischemia/reperfusion- (I/R-) induced AKI. In an in vivo model, streptozotocin-induced diabetic rats showed higher susceptibility to I/R injury with increased TXNIP expression, which was significantly attenuated by resveratrol (RES) treatment (10 mg/kg intraperitoneal daily injection for 7 consecutive days prior to I/R induction)...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27833015/trimethylamine-n-oxide-induces-inflammation-and-endothelial-dysfunction-in-human-umbilical-vein-endothelial-cells-via-activating-ros-txnip-nlrp3-inflammasome
#16
Xiaolei Sun, Xuefei Jiao, Yarong Ma, Yong Liu, Lei Zhang, Yanzheng He, Yunhui Chen
Recent research demonstrates that the choline-derived metabolite trimethylamine-N-oxide (TMAO) levels are strongly associated with atherosclerosis and cardiovascular risks. The NLRP3 inflammasome responds to exogenous and endogenous danger signals involved in the development of atherosclerosis. Moreover, thioredoxin-interactive protein (TXNIP) activation is a key event linked to NLRP3 inflammasome via reactive oxygen species (ROS). Whether TMAO prime NLRP3 inflammasome via ROS-TXNIP pathway remains unclear...
December 2, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27832995/protective-effect-of-sophoraflavanone-g-on-streptozotocin-stz-induced-inflammation-in-diabetic-rats
#17
Hanqing Wang, Li Chen, Liming Zhang, Xiaojuan Gao, Yinghua Wang, Tao Weiwei
The present study was designed to investigate the protective effect of Sophoraflavanone G (SG) on streptozotocin (STZ)-induced diabetic rats. The rats were intraperitoneally injected with STZ (35mg/kg). 7days later, the rats were intragastrically administered with Metformin (MET, 150mg/kg), SG (20mg/kg) or SG (40mg/kg) once daily for consecutive 30 days. The animals were anaesthetized, the blood and liver samples were also collected for further assay. SG significantly decreased the serum levels of glucose, insulin, aspartate transaminase (AST), alanine aminotransferase (ALT)...
December 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27816762/long-term-administration-of-advanced-glycation-end-product-stimulates-the-activation-of-nlrp3-inflammasome-and-sparking-the-development-of-renal-injury
#18
Wan-Ju Yeh, Hsin-Yi Yang, Man-Hui Pai, Chi-Hao Wu, Jiun-Rong Chen
The accumulation of advanced glycation end-products (AGEs) and the enhanced interaction of AGE with their cellular receptor (RAGE) have been implicated in the progression of chronic kidney disease. The purpose of this study was to examine whether the AGE/RAGE-induced nephrotoxic effects are associated with inflammasome activation and endothelial dysfunction. Chronic renal injury was examined in BALB/c mice by the long-term administration of carbonyl-AGE for 16 weeks. Endothelial dysfunction was detected by measuring the number of circulating endothelial progenitor cells (EPCs) and the levels of nitric oxide synthase (eNOS) and nitric oxide (NO) in kidneys...
January 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/27807222/the-emerging-role-of-thioredoxin-interacting-protein-in-myocardial-ischemia-reperfusion-injury
#19
Bing F Wang, Jun Yoshioka
Myocardial ischemia/reperfusion injury represents a major threat to human health and contributes to adverse cardiovascular outcomes worldwide. Despite the identification of numerous molecular mechanisms, understanding of the complex pathophysiology of this clinical syndrome remains incomplete. Thioredoxin-interacting protein (Txnip) has been of great interest in the past decade since it has been reported to be a critical regulator in human diseases with several important cellular functions. Thioredoxin-interacting protein binds to and inhibits thioredoxin, a redox protein that neutralizes reactive oxygen species (ROS), and through its interaction with thioredoxin, Txnip sensitizes cardiomyocytes to ROS-induced apoptosis...
November 2, 2016: Journal of Cardiovascular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27785530/activation-of-the-txnip-nlrp3-inflammasome-pathway-contributes-to-inflammation-in-diabetic-retinopathy-a-novel-inhibitory-effect-of-minocycline
#20
Wei Chen, Minjie Zhao, Shuzhi Zhao, Qianyi Lu, Lisha Ni, Chen Zou, Li Lu, Xun Xu, Huaijin Guan, Zhi Zheng, Qinghua Qiu
OBJECTIVE AND DESIGN: Chronic low-grade inflammation occurs in diabetic retinopathy (DR), but the underlying mechanism(s) remains (remain) unclear. NLRP3 inflammasome activation is involved in several other inflammatory diseases. Thus, we investigated the role of the NLRP3 inflammasome signaling pathway in the pathogenesis of DR. METHODS: Diabetes was induced in rats by streptozotocin treatment for 8 weeks. They were treated with NLRP3 shRNA or minocycline during the last 4 weeks...
October 26, 2016: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
keyword
keyword
12564
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"