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https://www.readbyqxmd.com/read/29662437/ketogenic-diet-improves-brain-ischemic-tolerance-and-inhibits-nlrp3-inflammasome-activation-by-preventing-drp1-mediated-mitochondrial-fission-and-endoplasmic-reticulum-stress
#1
Min Guo, Xun Wang, Yanxin Zhao, Qi Yang, Hongyan Ding, Qiang Dong, Xingdong Chen, Mei Cui
Background : Neuroprotective effects of ketogenic diets (KD) have been reported in stroke models, and nucleotide-binding domain (NOD)-like receptor protein 3 (NLRP3) inflammasome has also been implicated in the pathogenesis of stroke. This study aimed to investigate the effects of KD on NLRP3 inflammasome and explore the potential molecular mechanisms. Methods : In in vivo study, mice were fed with KD for 3 weeks and then subjected to middle cerebral artery occlusion/reperfusion (MCAO/R)-injury. In in vitro study, SH-SY-5Y cells were treated with β-hydroxybutyrate (BHB) followed by oxygen-glucose deprivation/reoxygenation (OGD/R)...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29653364/microrna-20a-protects-human-aortic-endothelial-cells-from-ox-ldl-induced-inflammation-through-targeting-tlr4-and-txnip-signaling
#2
Mantian Chen, Wei Li, Yi Zhang, Jieying Yang
MiR-20a has been previously reported to participate in the development of various human diseases. However, the role of miR-20a in the pathology of atherosclerosis remains elusive. The present study aimed to reveal the relationship between miR-20a expression and atherosclerosis using in vitro cell model. The expression level of miR-20a was detected in human aortic endothelial cells (HAECs) under Ox-LDL exposure. Meanwhile, the regulatory effects of miR-20a on predicted targets (TLR4 and TXNIP) were also determined...
April 10, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29649568/honokiol-alleviates-the-degeneration-of-intervertebral-disc-via-suppressing-the-activation-of-txnip-nlrp3-inflammasome-signal-pathway
#3
Pan Tang, Jia-Ming Gu, Zi-Ang Xie, Yu Gu, Zhi-Wei Jie, Kang-Mao Huang, Ji-Ying Wang, Shun-Wu Fan, Xue-Sheng Jiang, Zhi-Jun Hu
Intervertebral disc degeneration (IVDD) is a multifactorial disease and responsible for many spine related disorders, causes disability in the workforce and heavy social costs all over the world. Honokiol, a low molecular weight natural product, could penetrate into and distribute in IVDs to achieve therapeutic effect in a rat tail model. Therefore, the present study was undertaken to examine the antiinflammatory, antioxidation and chondroprotective effect of honokiol using nucleus pulposus cells and investigate its mechanisms to provide a new basis for future clinical treatment of IVDD...
April 9, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29568876/fisetin-administration-improves-lps-induced-acute-otitis-media-in-mouse-in-vivo
#4
Peng Li, Dan Chen, Yang Huang
Acute otitis media is one of the most common infectious diseases worldwide in spite of the widespread vaccination. The present study was conducted to explore the effects of fisetin on mouse acute otitis media models. The animal models were established by lipopolysaccharide (LPS) injection into the middle ear of mice via the tympanic membrane. Fisetin was administered to mice for ten days through intragastric administration immediate after LPS application. Hematoxylin and eosin (H&E) staining was performed and the pro-inflammatory cytokines, including interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), IL-6 and VEGF, were measured through enzyme-linked immunosorbent assay (ELISA) method and RT-qPCR analysis...
March 22, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29566008/genomic-and-transcriptomic-comparison-of-allergen-and-silver-nanoparticle-induced-mast-cell-degranulation-reveals-novel-non-immunoglobulin-e-mediated-mechanisms
#5
Monica Johnson, Nasser Alsaleh, Ryan P Mendoza, Indushekhar Persaud, Alison K Bauer, Laura Saba, Jared M Brown
Mast cells represent a crucial cell type in host defense; however, maladaptive responses are contributing factors in the pathogenesis of allergic diseases. Previous work in our laboratory has shown that exposure to silver nanoparticles (AgNPs) results in mast cell degranulation via a non-immunoglobulin E (IgE) mechanism. In this study, we utilized a systems biology approach to identify novel genetic factors playing a role in AgNP-induced mast cell degranulation compared to the classical activation by antigen-mediated FcεRI crosslinking...
2018: PloS One
https://www.readbyqxmd.com/read/29534438/expression-of-txnip-in-cancer-cells-and-regulation-by-1-25-oh-%C3%A2-d%C3%A2-is-it-really-the-vitamin-d%C3%A2-upregulated-protein
#6
Mohamed A Abu El Maaty, Fadi Almouhanna, Stefan Wölfl
Thioredoxin-interacting protein (TXNIP) was originally identified in HL-60 cells as the vitamin D₃ upregulated protein 1, and is now known to be involved in diverse cellular processes, such as maintenance of glucose homeostasis, redox balance, and apoptosis. Besides the initial characterization, little is known about if and how 1,25-dihydroxyvitamin D₃ [1,25(OH)₂D₃] induces TXNIP expression. We therefore screened multiple cancerous cell lines of different tissue origins, and observed induction, repression, or no change in TXNIP expression in response to 1,25(OH)₂D₃...
March 10, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29524408/downregulation-of-txnip-leads-to-high-proliferative-activity-and-estrogen-dependent-cell-growth-in-breast-cancer
#7
Jun Won Park, Su Hyung Lee, Gye-Hyung Woo, Hyo-Jung Kwon, Dae-Yong Kim
TXNIP is a potent tumor suppressor with reduced expression in various types of human cancer. The prognostic and predictive power of TXNIP has been recognized in human breast cancer. The aim of this study is to investigate the clinical relevance and functional roles of TXNIP downregulation in breast cancer. We examined TXNIP expression at the protein level in tissue microarray (TMA)-based human breast cancers and its correlation with clinical parameters and molecular markers on immunohistochemistry (IHC). Compared with normal tissues, TXNIP expression was significantly decreased in human breast cancer tissues and animal mammary tumors, along with tumor progression...
March 7, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29512754/3-5-4-tri-o-acetylresveratrol-attenuates-seawater-inhalation-induced-acute-respiratory-distress-syndrome-via-thioredoxin-1-pathway
#8
Yilin Zhao, Lijie Ma, Ruixuan Wang, Tingting Chen, Xueying Liu, Faguang Jin
The protecting effects of 3,5,4'-tri-O-acetylresveratrol (AC-Res) on seawater inhalation-induced acute respiratory distress syndrome (ARDS) by interfering with the activation of thioredoxin-1 (Trx-1) pathway were evaluated. Seawater inhalation-induced ARDS was assessed by magnitude of pulmonary edema and lung inflammation. Oxidative stress was tested by T-SOD activity and MDA content in lungs and cells. Besides, Trx-1, nuclear factor erythroid 2-related factor 2 (Nrf2) and Txnip expression were measured to explore how seawater induced oxidative stress and the mechanism by which AC-Res attenuated seawater inhalation-induced ARDS...
March 1, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29488135/thioredoxin-interacting-protein-txnip-in-cerebrovascular-and-neurodegenerative-diseases-regulation-and-implication
#9
REVIEW
Sanaz Nasoohi, Saifudeen Ismael, Tauheed Ishrat
Neurological diseases, including acute attacks (e.g., ischemic stroke) and chronic neurodegenerative diseases (e.g., Alzheimer's disease), have always been one of the leading cause of morbidity and mortality worldwide. These debilitating diseases represent an enormous disease burden, not only in terms of health suffering but also in economic costs. Although the clinical presentations differ for these diseases, a growing body of evidence suggests that oxidative stress and inflammatory responses in brain tissue significantly contribute to their pathology...
February 27, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29482933/deletion-of-thioredoxin-interacting-protein-ameliorates-high-fat-diet-induced-non-alcoholic-steatohepatitis-through-modulation-of-toll-like-receptor-2-nlrp3-inflammasome-axis-histological-and-immunohistochemical-study
#10
Islam N Mohamed, Nahla Reda Sarhan, Mohamed Ahmed Eladl, Azza B El-Remessy, Mohamed El-Sherbiny
Endemic prevalence of obesity is associated with alarming increases in non-alcoholic steatohepatitis (NASH) with limited available therapeutics. Toll-like receptor2 (TLR2) and Nod-like receptor protein 3 (NLRP3) Inflammasome are implicated in hepatic steatosis, inflammation and fibrosis; the histological landmark stages of NASH. TXNIP, a member of α-arrestin family activates NLRP3 in response to various danger stimuli. The aim of current work was to investigate the effect of TXNIP genetic deletion on histological manifestations of high fat diet-induced steatohepatitis and activation of TLR2-NLRP3-inflammasome axis...
February 23, 2018: Acta Histochemica
https://www.readbyqxmd.com/read/29477360/mros-txnip-axis-activates-nlrp3-inflammasome-to-mediate-renal-injury-during-ischemic-aki
#11
Yi Wen, Yi-Ran Liu, Tao-Tao Tang, Ming-Ming Pan, Sheng-Chun Xu, Kun-Ling Ma, Lin-Li Lv, Hong Liu, Bi-Cheng Liu
Ischemia/reperfusion (I/R) is a critical risk factor for acute kidney injury (AKI). Recent studies provided evidence that tubular epithelial cells (TEC)-associated inflammation aggravates kidney injury and impairs tissue repair after I/R injury. Here we demonstrated that the Nod-like receptor protein 3 (NLRP3) inflammasome is activated by mitochondrial reactive oxygen species (mROS) during I/R injury via direct interactions between the inflammasome and thioredoxin-interacting protein (TXNIP). Firstly, we found that NLRP3 inflammasome activation was induced by I/R injury, peaking at day 3 after reperfusion...
February 22, 2018: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/29475852/alcohol-dysregulates-mir-148a-in-hepatocytes-through-foxo1-facilitating-pyroptosis-via-txnip-overexpression
#12
Mi Jeong Heo, Tae Hyun Kim, Jueng Soo You, Delia Blaya, Pau Sancho-Bru, Sang Geon Kim
OBJECTIVE: Alcoholic liver disease (ALD) is a leading cause of death among chronic liver diseases. However, its pathogenesis has not been completely established. MicroRNAs (miRNAs) are key contributors to liver diseases progression. This study investigated hepatocyte-abundant miRNAs dysregulated by ALD, its impact on hepatocyte injury and the underlying basis. DESIGN: Alcoholic hepatitis (AH) human and animal liver samples and hepatocytes were used to assess miR-148a levels...
February 23, 2018: Gut
https://www.readbyqxmd.com/read/29475133/reactive-oxygen-species-promote-tubular-injury-in-diabetic-nephropathy-the-role-of-the-mitochondrial-ros-txnip-nlrp3-biological-axis
#13
Yachun Han, Xiaoxuan Xu, Chengyuan Tang, Peng Gao, Xianghui Chen, Xiaofen Xiong, Ming Yang, Shikun Yang, Xuejing Zhu, Shuguang Yuan, Fuyou Liu, Li Xiao, Yashpal S Kanwar, Lin Sun
NLRP3/IL-1β activation via thioredoxin (TRX)/thioredoxin-interacting protein (TXNIP) following mitochondria ROS (mtROS) overproduction plays a key role in inflammation. However, the involvement of this process in tubular damage in the kidneys of patients with diabetic nephropathy (DN) is unclear. Here, we demonstrated that mtROS overproduction is accompanied by decreases in TRX expression and TXNIP up-regulation. In addition, we discovered that mtROS overproduction is also associated with increases in NLRP3/IL-1β and TGF-β expression in the kidneys of patients with DN and db/db mice...
February 15, 2018: Redox Biology
https://www.readbyqxmd.com/read/29456721/combined-treatment-with-d-allose-docetaxel-and-radiation-inhibits-the-tumor-growth-in-an-in-vivo-model-of-head-and-neck-cancer
#14
Hiroshi Hoshikawa, Kazuyo Kamitori, Kanako Indo, Terushige Mori, Mizuna Kamata, Tomoko Takahashi, Masaaki Tokuda
The present study was designed to evaluate the effect of one rare sugar, D-allose, on normal human cells and cutaneous tissue, and to investigate the radiosensitizing and chemosensitizing potential of D-allose in an in vivo model of head and neck cancer. Results indicated that D-allose did not inhibit the growth of normal human fibroblasts TIG-1 cells, and no apoptotic changes were observed after D-allose and D-glucose treatment. The mRNA expression levels of thioredoxin interacting protein (TXNIP) in TIG-1 cells after D-allose treatment increased by 2-fold (50...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29433676/bioactive-phytochemicals-that-regulate-the-cellular-processes-involved-in-diabetic-nephropathy
#15
REVIEW
Amna Parveen, Mirim Jin, Sun Yeou Kim
BACKGROUND: Owing to the multiple causative factors, the current advances in medication for diabetic nephropathy (DN) do not appear to have improved therapies for patients. Furthermore, use of multiple synthetic medications has shown various adverse effects and ultimately leads to deterioration of the condition. Medicinal plants and their bioactive constituents are considered to be safer and more effective than synthetic medicines against various chronic diseases. Therefore, the use of natural products in the management of DN has been suggested...
January 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29404777/verapamil-inhibits-ser202-thr205-phosphorylation-of-tau-by-blocking-txnip-ros-p38-mapk-pathway
#16
Mariarosa Anna Beatrice Melone, Clemente Dato, Simona Paladino, Cinzia Coppola, Claudia Trebini, Maria Teresa Giordana, Lorena Perrone
PURPOSE: Oxidative stress is a hallmark of Alzheimer's Disease (AD) and promotes tau phosphorylation. Since Thioredoxin Interacting protein (TXNIP), the inhibitor of the anti-oxidant system of Thioredoxin, is up regulated in the hippocampus of AD patients, we investigated whether TXNIP plays a role in promoting tau phosphorylation and whether Verapamil, an inhibitor of TXNIP expression, prevents TXNIP downstream effects. METHODS: We analyzed TXNIP expression and tau phosphorylation in the hippocampus of the 5xFAD mice in the absence and presence of a pharmacological treatment with Verapamil...
February 5, 2018: Pharmaceutical Research
https://www.readbyqxmd.com/read/29401599/reduced-endothelial-thioredoxin-interacting-protein-protects-arteries-from-damage-induced-by-metabolic-stress-in-vivo
#17
Tatiana Bedarida, Alison Domingues, Stephanie Baron, Chrystophe Ferreira, Francoise Vibert, Charles-Henry Cottart, Jean-Louis Paul, Virginie Escriou, Pascal Bigey, Pascale Gaussem, Teddy Leguillier, Valerie Nivet-Antoine
Although thioredoxin-interacting protein (TXNIP) is involved in a variety of biologic functions, the contribution of endothelial TXNIP has not been well defined. To investigate the endothelial function of TXNIP, we generated a TXNIP knockout mouse on the Cdh5-cre background (TXNIPfl/fl cdh5cre). Control (TXNIPfl/fl) and TXNIPfl/fl cdh5cre mice were fed a high protein-low carbohydrate (HP-LC) diet for 3 mo to induce metabolic stress. We found that TXNIPfl/fl and TXNIPfl/fl cdh5cre mice on an HP-LC diet displayed impaired glucose tolerance and dyslipidemia concretizing the metabolic stress induced...
January 17, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29399631/dna-methylation-as-a-mediator-of-the-association-between-prenatal-adversity-and-risk-factors-for-metabolic-disease-in-adulthood
#18
Elmar W Tobi, Roderick C Slieker, René Luijk, Koen F Dekkers, Aryeh D Stein, Kate M Xu, P Eline Slagboom, Erik W van Zwet, L H Lumey, Bastiaan T Heijmans
Although it is assumed that epigenetic mechanisms, such as changes in DNA methylation (DNAm), underlie the relationship between adverse intrauterine conditions and adult metabolic health, evidence from human studies remains scarce. Therefore, we evaluated whether DNAm in whole blood mediated the association between prenatal famine exposure and metabolic health in 422 individuals exposed to famine in utero and 463 (sibling) controls. We implemented a two-step analysis, namely, a genome-wide exploration across 342,596 cytosine-phosphate-guanine dinucleotides (CpGs) for potential mediators of the association between prenatal famine exposure and adult body mass index (BMI), serum triglycerides (TG), or glucose concentrations, which was followed by formal mediation analysis...
January 2018: Science Advances
https://www.readbyqxmd.com/read/29394934/ire1%C3%AE-inhibition-decreased-txnip-nlrp3-inflammasome-activation-through-mir-17-5p-after-neonatal-hypoxic-ischemic-brain-injury-in-rats
#19
Di Chen, Brandon J Dixon, Desislava M Doycheva, Bo Li, Yang Zhang, Qin Hu, Yue He, Zongduo Guo, Derek Nowrangi, Jerry Flores, Valery Filippov, John H Zhang, Jiping Tang
BACKGROUND: The endoplasmic reticulum (ER) is responsible for the control of correct protein folding and protein function which is crucial for cell survival. However, under pathological conditions, such as hypoxia-ischemia (HI), there is an accumulation of unfolded proteins thereby triggering the unfolded protein response (UPR) and causing ER stress which is associated with activation of several stress sensor signaling pathways, one of them being the inositol requiring enzyme-1 alpha (IRE1α) signaling pathway...
February 2, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29386025/mirna-23a-cxcr4-regulates-neuropathic-pain-via-directly-targeting-txnip-nlrp3-inflammasome-axis
#20
Zhiqiang Pan, Qun Shan, Pan Gu, Xiao Min Wang, Lydia Wai Tai, Menglan Sun, Xin Luo, Liting Sun, Chi Wai Cheung
BACKGROUND: Chemokine CXC receptor 4 (CXCR4) in spinal glial cells has been implicated in neuropathic pain. However, the regulatory cascades of CXCR4 in neuropathic pain remain elusive. Here, we investigated the functional regulatory role of miRNAs in the pain process and its interplay with CXCR4 and its downstream signaling. METHODS: miRNAs and CXCR4 and its downstream signaling molecules were measured in the spinal cords of mice with sciatic nerve injury via partial sciatic nerve ligation (pSNL)...
January 31, 2018: Journal of Neuroinflammation
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