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Congenital diaphragmatic hernia

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https://www.readbyqxmd.com/read/29770109/fetoscopic-endoluminal-tracheal-occlusion-and-reestablishment-of-fetal-airways-for-congenital-diaphragmatic-hernia
#1
Lennart Van der Veeken, Francesca Maria Russo, Luc De Catte, Eduard Gratacos, Alexandra Benachi, Yves Ville, Kypros Nicolaides, Christoph Berg, Glenn Gardener, Nicola Persico, Pietro Bagolan, Greg Ryan, Michael A Belfort, Jan Deprest
Background: Congenital diaphragmatic hernia (CDH) is a congenital anomaly with high mortality and morbidity mainly due to pulmonary hypoplasia and hypertension. Temporary fetal tracheal occlusion to promote prenatal lung growth may improve survival. Entrapment of lung fluid stretches the airways, leading to lung growth. Methods: Fetal endoluminal tracheal occlusion (FETO) is performed by percutaneous sono-endoscopic insertion of a balloon developed for interventional radiology...
2018: Gynecological Surgery
https://www.readbyqxmd.com/read/29766307/the-laparoscopic-inguinal-and-diaphragmatic-defect-lidd-model-a-validation-study-of-a-novel-box-trainer-model
#2
Damir Ljuhar, Samuel Alexander, Sarah Martin, Ramesh Nataraja
BACKGROUND: Paediatric laparoscopic procedures are now becoming routine practice. Therefore, there is a need for simulated laparoscopic models to acquire part-procedural competency prior to direct patient contact in a safe learning environment. For this reason, we chose two paediatric conditions; inguinal hernia (IH) and congenital diaphragmatic hernia (CDH), which were combined to create the laparoscopic inguinal and diaphragmatic defect (LIDD) model. Our aim was to assess this novel surgical simulation model by determining its construct and content validity...
May 15, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29763850/laparoscopic-surgery-for-a-bochdalek-hernia-triggered-by-pregnancy-in-an-adult-woman-a-case-report
#3
Shotaro Matsudera, Masanobu Nakajima, Masakazu Takahashi, Hiroto Muroi, Maiko Kikuchi, Yosuke Shida, Keisuke Ihara, Satoru Yamaguchi, Kinro Sasaki, Takashi Tsuchioka, Hiroyuki Kato
INTRODUCTION: A Bochdalek hernia (BH) is a type of congenital diaphragmatic hernia. We herein describe an adult woman with a BH triggered by pregnancy and treated by laparoscopic surgery. PRESENTATION OF CASE: A 26-year-old woman was referred to our hospital because of abdominal pain and dyspnea resulting from a left diaphragmatic hernia. She was diagnosed with a BH and underwent laparoscopic surgery. Her postoperative progress was satisfactory, and no recurrence was found at follow-up approximately 1 year later...
May 1, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29754878/extracorporeal-membrane-oxygenation-ecmo-risk-stratification-in-newborns-with-congenital-diaphragmatic-hernia-cdh
#4
Tim Jancelewicz, Mary E Brindle, Matthew T Harting, Elizabeth A Tolley, Max R Langham, Pamela A Lally, Ankush Gosain, Stephanie A Storgion, David W Kays
BACKGROUND: A means for early postnatal stratification of ECMO risk in CDH newborns could be used to comparatively assess the utilization and outcomes of ECMO use between centers. While multiple CDH mortality risk calculators are available, no validated tool exists specifically for prediction of ECMO use. The purpose of this study was to derive and validate an ECMO risk stratification model. METHODS: The study population was obtained from CDH Study Group registry for the period between 2007 and 2016...
April 14, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29753526/prenatally-versus-postnatally-diagnosed-congenital-diaphragmatic-hernia-side-stage-and-outcome
#5
Carmen Mesas Burgos, Björn Frenckner, Matias Luco, Matthew T Harting, Pamela A Lally, Kevin P Lally
AIM: To compare outcomes between prenatally and postnatally diagnosed CDH in a large multicenter database of prospectively collected data and evaluate factors associated with poorer outcome for prenatally diagnosed CDH. MATERIAL AND METHODS: We used information from the multicenter, multinational CDH Study Group database on patients born between 2007 and 2015. We compared differences between prenatally and postnatally diagnosed CDH with respect to survival, side, size, ECMO needs, associated major cardiac malformations and liver position...
April 14, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29745254/treatment-of-rat-congenital-diaphragmatic-hernia-with-sildenafil-and-ns-304-selexipag-s-active-compound-at-the-pseudoglandular-stage-improves-lung-vasculature
#6
Daphne S Mous, Heleen M Kool, Petra E Burgisser, Marjon J Buscop-van Kempen, Koji Nagata, Anne Boerema-de Munck, Joost van Rosmalen, Oleh Dzyubachyk, Rene Mh Wijnen, Dick Tibboel, Robbert J Rottier
Patients with congenital diaphragmatic hernia (CDH) often suffer from severe pulmonary hypertension and the choice of current vasodilator therapy is mostly based on trial and error. Since pulmonary vascular abnormalities are already present early during development, we performed a study to modulate these pulmonary vascular changes at an early stage during gestation. Pregnant Sprague-Dawley rats were treated with nitrofen at day 9.5 of gestation (E9.5) to induce CDH in the offspring and subsequently the phosphodiesterase-5 inhibitor sildenafil and/or the novel prostaglandin-I receptor agonist selexipag (NS-304) were administered from E17...
May 10, 2018: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/29735873/bochdalek-hernia-and-intrathoracic-ectopic-kidney-presentation-of-two-case-reports-and-review-of-the-literature
#7
M Sarac, U Bakal, T Tartar, S Canpolat, A Kara, A Kazez
Bochdalek hernia is a congenital abnormality with high morbidity and mortality characterized by passage of the abdominal organs into the thoracic cavity through a diaphragmatic defect. Intrathoracic location of abdominal organs such as kidneys is very rare, with a reported incidence of only 0.25% in the literature. Herein, we present two cases of Bochdalek hernia with a herniation of intra-abdominal organ such as kidney that was treated in our clinic and compare this rare case with those in the literature. In both cases, the functionally normal kidneys were left in situ during diaphragmatic repair...
May 2018: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29728412/challenge-of-determining-true-outcome-of-congenital-diaphragmatic-hernia
#8
EDITORIAL
Carl Davis, Gregor M Walker
No abstract text is available yet for this article.
May 4, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/29720002/early-prenatal-ultrasound-diagnosis-of-congenital-thoracic-malformations
#9
Lea Bentur, Michal Gur, Mordechai Pollak, Kamal Masarweh, Ido Solt, Moshe Bronshtein
OBJECTIVES: To evaluate and describe the spectrum and rate of congenital thoracic malformations (CTMs) diagnosed by early prenatal sonography (gestational age (GA) less than 16 weeks). METHODS: A retrospective, cross-sectional analysis of prenatal ultrasound screening tests in a community-based clinic. RESULTS: In 2001-2017, 31 261 prenatal ultrasound tests detected 31 CTMs at a gestational age of 15.2 (range, 11.6-16.0) weeks. The most common malformation was congenital pleural effusion (CPE) (15 fetuses, 0...
May 2, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29714432/extracorporeal-membrane-oxygenation-support-in-neonates-a-single-center-experience-in-turkey
#10
Emel Okulu, F. Begüm Atasay, Gaffari Tunç, Hasan Akduman, Ömer Erdeve, Saadet Arsan, Zeynep Eyileten, Tayfun Uçar, H. Ercan Tutar
Background/aim: Extracorporeal membrane oxygenation (ECMO) is a form of life support for patients with respiratory failure, cardiac failure, or both. The aim of this study was to evaluate neonates supported with ECMO and report our experience as a Turkish neonatal intensive care unit. Materials and methods: We retrospectively reviewed 11 newborn infants treated with ECMO at Ankara University for respiratory and cardiac failure. We reported the demographic, diagnostic, laboratory, and clinical data of the patients...
April 30, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29713814/prenatal-intervention-for-the-management-of-congenital-diaphragmatic-hernia
#11
REVIEW
Mariatu A Verla, Candace C Style, Oluyinka O Olutoye
Congenital diaphragmatic hernia (CDH) is the result of incomplete formation of the diaphragm that occurs during embryogenesis. The defect in the diaphragm permits the herniation of abdominal organs into the thoracic cavity contributing to the impairment of normal growth and development of the fetal lung. In addition to the hypoplastic lung, anomalies of the pulmonary arterioles worsen the pulmonary hypertension that can have detrimental effects in severe cases. Most cases of CDH can be effectively managed postnatally...
April 30, 2018: Pediatric Surgery International
https://www.readbyqxmd.com/read/29712845/systematic-analysis-of-copy-number-variation-associated-with-congenital-diaphragmatic-hernia
#12
Qihui Zhu, Frances A High, Chengsheng Zhang, Eliza Cerveira, Meaghan K Russell, Mauro Longoni, Maliackal P Joy, Mallory Ryan, Adam Mil-Homens, Lauren Bellfy, Caroline M Coletti, Pooja Bhayani, Regis Hila, Jay M Wilson, Patricia K Donahoe, Charles Lee
Congenital diaphragmatic hernia (CDH), characterized by malformation of the diaphragm and hypoplasia of the lungs, is one of the most common and severe birth defects, and is associated with high morbidity and mortality rates. There is growing evidence demonstrating that genetic factors contribute to CDH, although the pathogenesis remains largely elusive. Single-nucleotide polymorphisms have been studied in recent whole-exome sequencing efforts, but larger copy number variants (CNVs) have not yet been studied on a large scale in a case control study...
April 30, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29708274/congenital-pleuroperitoneal-hernia-presenting-as-gastrothorax-in-five-cavalier-king-charles-spaniel-dogs
#13
M Rossanese, M Pivetta, N Pereira, R Burrow
Five cavalier King Charles spaniels were examined for acute onset of respiratory distress. Thoracic radiographs demonstrated diaphragmatic hernia and tension gastrothorax, visible as a distended stomach occupying the left caudal thoracic cavity. Exploratory midline coeliotomy confirmed congenital pleuroperitoneal diaphragmatic hernia with herniation and dilatation of the stomach. The hernia configuration was consistent in all cases, with a defect affecting the left diaphragmatic crus. Congenital pleuroperitoneal diaphragmatic hernia is a rare condition caused by a defect in the dorsolateral diaphragm...
April 30, 2018: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/29702180/hypoplastic-left-heart-syndrome-with-a-hypoplastic-lung-in-congenital-diaphragmatic-hernia-what-should-be-done-first
#14
EDITORIAL
Shu-Chien Huang, Wen-Ming Hsu
No abstract text is available yet for this article.
April 24, 2018: Seminars in Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29689737/improving-outcome-in-congenital-diaphragmatic-hernia-experience-of-a-tertiary-center-without-ecmo
#15
J Pimenta, P Vaz Silva, C Pinto, A Dinis, L Carvalho, O de Castro, F Neves
BACKGROUND: Congenital diaphragmatic hernia (CDH) has a high mortality rate, representing a therapeutic challenge. Prenatal diagnosis (PND) is essential in defining optimal perinatal strategy, particularly delivery planning. Hospital Pediátrico de Coimbra is the referral centre for all neonatal surgery, particularly CDH, for the central region of Portugal. The aim was to evaluate clinical management and outcome of newborns with CDH. METHODS: An exploratory retrospective study made up of newborns admitted to PICU with CDH was undertaken between January 1995 and December 2014...
2018: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/29685785/validation-of-a-low-cost-do-it-yourself-model-for-neonatal-thoracoscopic-congenital-diaphragmatic-hernia-repair
#16
Pedro Reino-Pires, Manuel Lopez
OBJECTIVE: We aimed to develop and validate a low cost, do-it-yourself model for neonatal thoracoscopic congenital diaphragmatic hernia (CDH). DESIGN: Volunteers with varying skills in neonatal minimally invasive surgery tested and evaluated the model simulating a neonatal thoracoscopic CDH repair. The model was built from ordinary materials purchased in a dime store: a small food container, a neoprene band simulating a diaphragm, an inflated balloon simulating a spleen, a tissue chord simulating intestine, and a body wash sponge simulating a collapsed lung...
April 20, 2018: Journal of Surgical Education
https://www.readbyqxmd.com/read/29679560/developmental-origin-and-morphogenesis-of-the-diaphragm-an-essential-mammalian-muscle
#17
Elizabeth M Sefton, Mirialys Gallardo, Gabrielle Kardon
The diaphragm is a mammalian skeletal muscle essential for respiration and for separating the thoracic and abdominal cavities. Development of the diaphragm requires the coordinated development of muscle, muscle connective tissue, tendon, nerves, and vasculature that derive from different embryonic sources. However, defects in diaphragm development are common and the cause of an often deadly birth defect, Congenital Diaphragmatic Hernia (CDH). Here we comprehensively describe the normal developmental origin and complex spatial-temporal relationship between the different developing tissues to form a functional diaphragm using a developmental series of mouse embryos genetically and immunofluorescently labeled and analyzed in whole mount...
April 18, 2018: Developmental Biology
https://www.readbyqxmd.com/read/29644321/delayed-traumatic-parasternal-hernia-causes-jejunal-necrosis-a-case-report
#18
Huimin Zhao, Ru Gao, Donghui Jia, Aiming Li
Diaphragmatic injury is a common clinical condition, and it may be difficult to avoid diaphragmatic hernia if detection and treatment is not timely. Parasternal hernia is mostly congenital. It is relatively rare in adults, and intestinal obstruction as a complication of intrathoracic intestinal herniation occurs only rarely. We treated a patient in whom parasternal hernia occurred 2 years after thoracic injuries. We present the plain radiography and computed tomography findings of this adult patient with acute abdomen symptoms caused by parasternal hernia...
June 2017: Trauma Case Reports
https://www.readbyqxmd.com/read/29628412/the-left-ventricle-in-congenital-diaphragmatic-hernia-implications-for-the-management-of-pulmonary-hypertension
#19
John P Kinsella, Robin H Steinhorn, Mary P Mullen, Rachel K Hopper, Roberta L Keller, D Dunbar Ivy, Eric D Austin, Usha S Krishnan, Erika B Rosenzweig, Jeffrey R Fineman, Allen D Everett, Brian D Hanna, Tilman Humpl, J Usha Raj, Steven H Abman
No abstract text is available yet for this article.
April 5, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29627662/follow-up-of-fetuses-with-congenital-diaphragmatic-hernia-the-quantitative-lung-index
#20
Carlota Rodó, Tamara Illescas, Silvia Arévalo, Santiago Pérez-Hoyos, Elena Carreras
OBJECTIVE: To assess the longitudinal behavior of Quantitative Lung Index (QLI) for the follow-up of fetuses with congenital diaphragmatic hernia. STUDY DESIGN: Retrospective study of fetuses with isolated left congenital diaphragmatic hernia. The fetuses were assessed by ultrasound at different gestational ages and QLI was retrospectively calculated by means of previous lung-to-head ratio measurements. We used a random effects model (mixed model with repeated measurements) to compare the performance of the QLI in operated and non-operated fetuses throughout pregnancy...
March 26, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
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