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https://www.readbyqxmd.com/read/27926850/background-suppression-in-imaging-gold-nanorods-through-detection-of-anti-stokes-emission
#1
Aquiles Carattino, Veer I P Keizer, Marcel J M Schaaf, Michel Orrit
Metallic nanoparticles have opened the possibility of imaging, tracking, and manipulating biological samples without time limitations. Their low photoluminescence quantum yield, however, makes them hard to detect under high background conditions. In this study we show that it is possible to image gold nanorods by detecting their anti-Stokes emission under resonant excitation. We show that even in the membrane of a cell containing the fluorescent dye Atto 647N, the signal/background of the anti-Stokes emission can be >10, while it is impossible to image the particles with the Stokes emission...
December 6, 2016: Biophysical Journal
https://www.readbyqxmd.com/read/27924952/a-competitive-bio-barcode-amplification-immunoassay-for-small-molecules-based-on-nanoparticles
#2
Pengfei Du, Maojun Jin, Ge Chen, Chan Zhang, Zejun Jiang, Yanxin Zhang, Pan Zou, Yongxin She, Fen Jin, Hua Shao, Shanshan Wang, Lufei Zheng, Jing Wang
A novel detection method of small molecules, competitive bio-barcode amplification immunoassay, was developed and described in this report. Through the gold nanoparticles (AuNPs) probe and magnetic nanoparticles (MNPs) probe we prepared, only one monoclonal antibody can be used to detect small molecules. The competitive bio-barcode amplification immunoassay overcomes the obstacle that the bio-barcode assay cannot be used in small molecular detection, as two antibodies are unable to combine to one small molecule due to its small molecular structure...
December 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27924783/functionalized-gold-nanoparticles-manifested-as-potent-carriers-for%C3%A2-nucleolar-targeting
#3
Reza Shahbazi, Ilyas Ozcicek, Gurkan Ozturk, Kezban Ulubayram
It is generally known that gold nanoparticles are localised in the cytoplasm and, if synthesised in small sizes or functionalized with specific proteins, they enter the cell nucleus. However, there is no report emphasising the importance of surface functionalization in their accumulation in the nucleolus. Here, for the first time in the literature, it is proposed that functionalization of gold nanoparticles with a thin layer of polyethyleneimine (PEI) spearheads them to the nucleolus of hard-to-transfect post-mitotic dorsal root ganglion neurones in a size-independent manner...
January 13, 2017: Nanotechnology
https://www.readbyqxmd.com/read/27924337/allosteric-effects-of-gold-nanoparticles-on-human-serum-albumin
#4
Qing Shao, Carol K Hall
The ability of nanoparticles to alter protein structure and dynamics plays an important role in their medical and biological applications. We investigate allosteric effects of gold nanoparticles on human serum albumin protein using molecular simulations. The extent to which bound nanoparticles influence the structure and dynamics of residues distant from the binding site is analyzed. The root mean square deviation, root mean square fluctuation and variation in the secondary structure of individual residues on a human serum albumin protein are calculated for four protein-gold nanoparticle binding complexes...
December 7, 2016: Nanoscale
https://www.readbyqxmd.com/read/27922827/gold-nanoparticles-as-scaffolds-for-poor-water-soluble-and-difficult-to-vehiculate-antiparkinson-codrugs
#5
A Di Crescenzo, I Cacciatore, M Petrini, M D'Alessandro, N Petragnani, P Del Boccio, P Di Profio, S Boncompagni, G Spoto, H Turkez, P Ballerini, A Di Stefano, A Fontana
We report the facile and non-covalent preparation of gold nanoparticles (AuNPs) stabilized by an antiparkinson codrug based on lipoic acid (LA). The obtained AuNPs appear stable in both dimethyl sulfoxide and fetal bovine serum and able to load an amount of codrug double the weight of gold. These NPs were demonstrated to be safe and biocompatible towards primary human blood cells and human neuroblastoma cells, one of the most widely used cellular models to study dopaminergic neural cells, therefore are ideal drug carriers for difficult to solubilize molecules...
December 6, 2016: Nanotechnology
https://www.readbyqxmd.com/read/27921518/increased-radio-toxicity-in-two-cancerous-cell-lines-irradiated-by-low-and-high-energy-photons-in-the-presence-of-thio-glucose-bound-gold-nanoparticles
#6
Shokouhozaman Soleymanifard, Atefeh Rostami, Seyed Amir Aledavood, Maryam Moghadam Matin, Ameneh Sazgarnia
PURPOSE: Gold nanoparticles modified by thio-glucose have been believed to increase the toxicity of radiotherapy in human malignant cells. We report the effect of thio-glucose-bound gold nanoparticles (Glu-G nanoparticles), 16 nm in size, on two human lung (QU-DB) and breast (MCF7) cancer cell lines combined with kilo and megavoltage X-rays. MATERIALS AND METHODS: The shape and surface characteristics, the size distribution and light absorption spectrum of the prepared nanoparticles were measured by transmission electron microscopy, dynamic light scattering, and Ultraviolet-Visible spectrophotometry, respectively...
December 6, 2016: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/27921355/catalysis-driven-self-thermophoresis-of-janus-plasmonic-nanomotors
#7
Weiwei Qin, Tianhuan Peng, Yanjing Gao, Fei Wang, Xiaocai Hu, Kun Wang, Jiye Shi, Di Li, Jicun Ren, Chunhai Fan
It is highly demanding to design active nanomotors that can move in response to specific signals with controllable rate and direction. A catalysis-driven nanomotor was constructed by designing catalytically and plasmonically active Janus gold nanoparticles (Au NPs), which generate an asymmetric temperature gradient of local solvent surrounding NPs in catalytic reactions. The self-thermophoresis behavior of the Janus nanomotor is monitored from its inherent plasmonic response. The diffusion coefficient of the self-thermophoresis motion is linearly dependent on chemical reaction rate, as described by a stochastic model...
December 6, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27921346/bottom-up-meets-top-down-patchy-hybrid-nonwovens-as-an-efficient-catalysis-platform
#8
Judith Schöbel, Matthias Burgard, Christian Hils, Roland Dersch, Martin Dulle, Kirsten Volk, Matthias Karg, Andreas Greiner, Holger Schmalz
Heterogeneous catalysis with supported nanoparticles (NPs) is a highly active field of research. However, the efficient stabilization of NPs without deteriorating their catalytic activity is challenging. By combining top-down (coaxial electrospinning) and bottom-up (crystallization-driven self-assembly) approaches, we prepared patchy nonwovens with functional, nanometer-sized patches on the surface. These patches can selectively bind and efficiently stabilize gold nanoparticles (AuNPs). The use of these AuNP-loaded patchy nonwovens in the alcoholysis of dimethylphenylsilane led to full conversion under comparably mild conditions and in short reaction times...
December 6, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27921316/light-triggered-assembly-of-gold-nanoparticles-for-photothermal-therapy-and-photoacoustic-imaging-of-tumors-in-vivo
#9
Xiaju Cheng, Rui Sun, Ling Yin, Zhifang Chai, Haibin Shi, Mingyuan Gao
Photocross-linkable Au nanoparticles are prepared through surface decoration of photolabile diazirine moieties. Both in vitro and in vivo studies indicate that the light-triggered cross-linking can dramatically shift the surface plasmon resonance of Au nanoparticles to near-infrared regions, which in consequence remarkably enhances their efficacy for photothermal therapy and photoacoustic imaging of tumors in vivo.
December 6, 2016: Advanced Materials
https://www.readbyqxmd.com/read/27921110/multifunctional-pei-entrapped-gold-nanoparticles-enable-efficient-delivery-of-therapeutic-sirna-into-glioblastoma-cells
#10
Lingdan Kong, Jieru Qiu, Wenjie Sun, Jia Yang, Mingwu Shen, Lu Wang, Xiangyang Shi
RNA interference (RNAi) has been considered as a promising strategy for effective treatment of cancer. However, the easy degradation of small interfering RNA (siRNA) limits its extensive applications in gene therapy. For safe and effective delivery of siRNA, a novel vector system possessing excellent biocompatibility, highly efficient transfection efficiency and specific targeting properties has to be considered. In this study, we report the use of polyethyleneimine (PEI)-entrapped gold nanoparticles (Au PENPs) modified with an arginine-glycine-aspartic (Arg-Gly-Asp, RGD) peptide via a poly(ethylene glycol) (PEG) spacer as a vector for Bcl-2 (B-cell lymphoma-2) siRNA delivery to glioblastoma cells...
December 6, 2016: Biomaterials Science
https://www.readbyqxmd.com/read/27921087/acute-and-chronic-effects-of-gold-nanoparticles-on-sperm-parameters-and-chromatin-structure-in-mice
#11
Mahsa Nazar, Ali Reza Talebi, Mohammad Hosseini Sharifabad, Abolghasem Abbasi, Arezoo Khoradmehr, Amir Hossein Danafar
BACKGROUND: The particles in the range of 1-100 nm are called nanoparticles. Gold nanoparticle is one of the most important metal nanoparticles with wide usage. OBJECTIVE: This study investigated the effects of gold nanoparticles on sperm parameters and chromatin structure in mice. MATERIALS AND METHODS: In this experimental study, 72 male bulb-c mice were divided into 9 groups including: 4 Sham groups (Sc 1-4), 4 experimental groups (Au 1-4), and 1 control group (C)...
October 2016: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/27920896/assessing-the-hyperthermic-properties-of-magnetic-heterostructures-the-case-of-gold-iron-oxide-composites
#12
Elvira Fantechi, Paula M Castillo, Erika Conca, Francesca Cugia, Claudio Sangregorio, Maria Francesca Casula
Gold-iron oxide composites were obtained by in situ reduction of an Au(III) precursor by an organic reductant (either potassium citrate or tiopronin) in a dispersion of preformed iron oxide ultrasmall magnetic (USM) nanoparticles. X-ray diffraction, transmission electron microscopy, chemical analysis and mid-infrared spectroscopy show the successful deposition of gold domains on the preformed magnetic nanoparticles, and the occurrence of either citrate or tiopronin as surface coating. The potential of the USM@Au nanoheterostructures as heat mediators for therapy through magnetic fluid hyperthermia was determined by calorimetric measurements under sample irradiation by an alternating magnetic field with intensity and frequency within the safe values for biomedical use...
December 6, 2016: Interface Focus
https://www.readbyqxmd.com/read/27920892/surface-modification-and-cellular-uptake-evaluation-of-au-coated-ni80fe20-nanodiscs-for-biomedical-applications
#13
Gabriele Barrera, Loredana Serpe, Federica Celegato, Marco Coїsson, Katia Martina, Roberto Canaparo, Paola Tiberto
A nanofabrication technique based on self-assembling of polystyrene nanospheres is used to obtain magnetic Ni80Fe20 nanoparticles with a disc shape. The free-standing nanodiscs (NDs) have diameter and thickness of about 630 nm and 30 nm, respectively. The versatility of fabrication technique allows one to cover the ND surface with a protective gold layer with a thickness of about 5 nm. Magnetization reversal has been studied by room-temperature hysteresis loop measurements in water-dispersed free-standing NDs...
December 6, 2016: Interface Focus
https://www.readbyqxmd.com/read/27919625/an-insight-study-on-hptlc-fingerprinting-of-mukia-maderaspatana-mechanism-of-bioactive-constituents-in-metal-nanoparticle-synthesis-and-its-activity-against-human-pathogens
#14
G Karthiga Devi, K Sathish Kumar, R Parthiban, K Kalishwarlal
The present work reports the development of a Simple, rapid and eco-friendly route for the biosynthesis of gold and silver nanoparticles and their antimicrobial activity against gram positive and gram negative bacterial pathogens in the wound infected area. The synthesis was done using Mukia maderasapatna plant extract as a reducing agent. FT-IR analysis reported that the methanol extract was found to contain maximum number of functional groups which is responsible for the reduction of metal ions to metal nanoparticles...
December 2, 2016: Microbial Pathogenesis
https://www.readbyqxmd.com/read/27918830/the-antiangiogenic-effects-of-gold-nanoparticles-on-experimental-choroidal-neovascularization-in-mice
#15
Young-Jung Roh, Chang Rae Rho, Won-Kyung Cho, Seungbum Kang
Purpose: The purpose of this study was to evaluate the antiangiogenic effect of gold nanoparticles (AuNPs) on experimental choroidal neovascularization (CNV) in mice. Methods: Choroidal neovascularization was induced by rupturing the Bruch's membrane using laser photocoagulation in C57BL/6 mice. The following day, intravitreal injections of AuNPs were administered. The control group received PBS injection of the same volume. Two weeks after laser injury, CNV lesions were evaluated by examination of choroidal flat-mounts using fluorescein-labeled dextran and immunofluorescence staining with isolectin B4...
December 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27918602/analytical-methods-based-on-the-light-scattering-of-plasmonic-nanoparticles-at-the-single-particle-level-with-dark-field-microscopy-imaging
#16
Tian Li, Xi Wu, Feng Liu, Na Li
This minireview summarizes analytical methods based on the light-scattering of plasmonic nanoparticles, primarily gold nanoparticles (AuNPs), at the single particle level from recent year publications. Examples are presented to illustrate simple and highly sensitive approaches based on AuNP localized surface plasmon resonance light-scattering with the dark-field microscopy imaging technology.
December 5, 2016: Analyst
https://www.readbyqxmd.com/read/27918447/enhanced-antimicrobial-and-anticancer-activity-of-silver-and-gold-nanoparticles-synthesised-using-sargassum-incisifolium-aqueous-extracts
#17
Mokone Mmola, Marilize Le Roes-Hill, Kim Durrell, John J Bolton, Nicole Sibuyi, Mervin E Meyer, Denzil R Beukes, Edith Antunes
A detailed, methodical approach was used to synthesise silver and gold nanoparticles using two differently prepared aqueous extracts of the brown algae Sargassum incisifolium. The efficiency of the extracts in producing nanoparticles were compared to commercially available brown algal fucoidans, a major constituent of brown algal aqueous extracts. The nanoparticles were characterised using TEM, XRD and UV/Vis spectroscopy and zeta potential measurements. The rate of nanoparticle formation was assessed using UV/Vis spectroscopy and related to the size, shape and morphology of the nanoparticles as revealed by TEM...
December 2, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27918129/photo-modulated-therapeutic-protein-release-from-a-hydrogel-depot-using-visible-light
#18
Johan S Basuki, Fengxiang Qie, Xavier Mulet, Randy Suryadinata, Aditya V Vashi, Yong Y Peng, Lingli Li, Xiaojuan Hao, Tianwei Tan, Timothy C Hughes
The use of biomacromolecular therapeutics has revolutionized disease treatment, but frequent injections are required owing to their short half-life in vivo. Thus there is a need for a drug delivery system that acts as a reservoir and releases the drug remotely "on demand". Here we demonstrate a simple light-triggered local drug delivery system through photo-thermal interactions of polymer-coated gold nanoparticles (AuNPs) inside an agarose hydrogel as therapeutic depot. Localized temperature increase induced by the visible light exposure caused reversible softening of the hydrogel matrix to release the pre-loaded therapeutics...
December 5, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27917689/green-synthesis-of-gold-and-silver-nanoparticles-using-aqueous-extract-of-cibotium-barometz-root
#19
Dandan Wang, Josua Markus, Chao Wang, Yeon-Ju Kim, Ramya Mathiyalagan, Verónica Castro Aceituno, Sungeun Ahn, Deok Chun Yang
Green synthesis of gold (CB-AuNps) and silver (CB-AgNps) nanoparticles using Cibotium barometz root extract was highlighted. CB-AuNps were synthesized almost instantly and CB-AgNps were formed after 25 min in a heated aqueous extract. The formation of CB-AuNps and CB-AgNps was detected at 548 and 412 nm; they were spherical with crystallite sizes of 6 nm and 23 nm, respectively. CB-AgNps were further investigated for their antimicrobial activity against Escherichia, Staphylococcus aureus, Salmonella enterica, and Pseudomonas aeruginosa...
December 4, 2016: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/27917407/microwave-heating-of-synthetic-skin-samples-for-potential-treatment-of-gout-using-the-metal-assisted-and-microwave-accelerated-decrystallization-technique
#20
Salih Toker, Zainab Boone-Kukoyi, Nishone Thompson, Hillary Ajifa, Travis Clement, Birol Ozturk, Kadir Aslan
Physical stability of synthetic skin samples during their exposure to microwave heating was investigated to demonstrate the use of the metal-assisted and microwave-accelerated decrystallization (MAMAD) technique for potential biomedical applications. In this regard, optical microscopy and temperature measurements were employed for the qualitative and quantitative assessment of damage to synthetic skin samples during 20 s intermittent microwave heating using a monomode microwave source (at 8 GHz, 2-20 W) up to 120 s...
November 30, 2016: ACS Omega
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