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https://www.readbyqxmd.com/read/29166558/understanding-the-cellular-uptake-of-ph-responsive-zwitterionic-gold-nanoparticles-a-computer-simulation-study
#1
Xuebo Quan, Daohui Zhao, Libo Li, Jian Zhou
Surface functionalization of nanoparticles (NPs) with stealth polymers (e.g., hydrophilic and zwitterionic polymers) has become a common strategy to resist non-specific protein adsorption recently. Understanding the role of surface decoration on NP-biomembrane interactions is of great significance to promote the application of NPs in biomedical fields. Herein, using coarse-grained molecular dynamics (CGMD) simulations, we investigate the interactions between stealth polymer-coated gold nanoparticles (AuNPs) and lipid membranes...
November 22, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29166557/impact-of-crosslinker-valency-on-gold-nanoparticle-aggregate-formation-and-cellular-uptake
#2
Alice Liu, Jacob M Berlin
Synthesis of spherical, biocompatible nanoparticle aggregates using a small molecular crosslinker is a simple and flexible approach for the controlled assembly of gold nanoparticles. This strategy can be extended to a variety of crosslinkers, making it possible to the test the effect of crosslinker properties on aggregate formation and physicochemical properties. Here we synthesized aggregates using a series of structurally homologous crosslinkers with differing valencies. These aggregates have the same size, morphology, surface charge, surface coating, and stability in salt, media, and low pH conditions, but they differ in their stability to cyanide etching and uptake by cells...
November 22, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29166054/modeling-super-resolution-sers-using-a-t-matrix-method-to-elucidate-molecule-nanoparticle-coupling-and-the-origins-of-localization-errors
#3
Charles W Heaps, George C Schatz
A computational method to model diffraction-limited images from super-resolution surface-enhanced Raman scattering microscopy is introduced. Despite significant experimental progress in plasmon-based super-resolution imaging, theoretical predictions of the diffraction limited images remain a challenge. The method is used to calculate localization errors and image intensities for a single spherical gold nanoparticle-molecule system. The light scattering is calculated using a modification of generalized Mie (T-matrix) theory with a point dipole source and diffraction limited images are calculated using vectorial diffraction theory...
June 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29166021/differences-in-the-aspect-ratio-of-gold-nanorods-that-induce-defects-in-cell-membrane-models
#4
Paula M P Lins, Valeria Spolon Marangoni, Thiers M Uehara, Paulo Barbeitas Miranda, Valtencir Zucolotto, Juliana Cancino Bernardi
Understanding the interactions between biomolecules and nanomaterials is of great importance for many areas of nanomedicine and bioapplications. Although studies in this area have been performed, the interactions between cell membranes and nanoparticles are not fully understood. Here, we investigate the interactions that occur between the Langmuir monolayers of dipalmitoylphosphatidyl glycerol (DPPG) and dipalmitoylphosphatidyl choline (DPPC) with gold nanorods (NR) - with three aspect ratios - and gold nanoparticles...
November 22, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29165496/fluorescence-quenching-based-signal-amplification-on-immunochromatography-test-strips-for-dual-mode-sensing-of-two-biomarkers-of-breast-cancer
#5
Bo Zhang, Wenjuan Ma, Fuxin Li, Weichen Gao, Qian Zhao, Weipan Peng, Jiafang Piao, Xiaoli Wu, Hanjie Wang, Xiaoqun Gong, Jin Chang
Recently, immunochromatography test strips (ICTS) have been fully developed for point-of-care testing (POCT). However, the intrinsic limitations including non-quantitative detection of colloidal gold ICTS and low sensitivity of fluorescence ICTS (FICTS) significantly restrict their further application in clinical diagnosis. Taking advantages of rapid colorimetric qualitative detection and fluorescence quantitation, we designed a kind of sensitive and dual-mode magnetic FICTS (mFICTS) based on PLGA@Fe3O4 super-paramagnetic nanosphere (SPMN) probes quenching multiplex fluorescer on the test line through sandwich immunoreactions...
November 22, 2017: Nanoscale
https://www.readbyqxmd.com/read/29165073/recent-progress-in-delivery-of-therapeutic-and-imaging-agents-utilizing-organic-inorganic-hybrid-nanoparticles
#6
Haque Sheikh Tanzina, Ezharul Chowdhury
Delivery of conventional small molecule drugs and currently evolving nucleic acid-based therapeutics, such as small interfering RNAs (siRNAs) and genes, and contrast agents for high resolution imaging, to the target site of action is highly demanding to increase the therapeutic and imaging efficacy while minimizing the off-target effects of the delivered molecules, as well as develop novel therapeutic and imaging approaches. Organic-inorganic hybrid nanoparticles offer a number of advantages by combining the unique properties of the organic and inorganic counterparts, thus improving the pharmacokinetic behavior and targetability of drugs and contrast agents, and conferring the exclusive optical and magnetic properties for both therapeutic and imaging purposes...
November 19, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/29164862/fabrication-of-magnetic-conjugation-clusters-via-intermolecular-assembling-for-ultrasensitive-surface-plasmon-resonance-spr-detection-in-wide-range-concentration
#7
Zhichao Lou, He Han, Ming Zhou, Jinfeng Wan, Qian Sun, Xiaoyan Zhou, Ning Gu
Herein, a novel sandwich surface plasmon resonance (SPR) detection assay, which utilizes prion disease-associated isoform (PrPSc) conjugating magnetic nanoparticle clusters (nanoparticle-organic clusters, NOCs) as signal amplification reagents, is constructed for ultrasensitive detection of PrPSc. Due to the highly specific affinity of aptamer-Fe3O4 nanoparticles (AMNPs) towards PrPSc and the intermolecular assembly behaviors among PrPSc, PrPSc conjugating magnetic nanoparticle clusters were obtained after the incubation of AMNPs and PrPSc, and the subsequent concentration processes in an external magnetic field...
November 22, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29164714/very-green-photosynthesis-of-gold-nanoparticles-by-a-living-aquatic-plant-photoreduction-of-au-iii-by-the-seaweed-ulva-armoricana
#8
Ofhani Christopher Mukhoro, Wiets D Roos, Mohammed Jaffer, John J Bolton, Martin J Stillman, Denzil R Beukes, Edith Antunes
Light-assisted in vivo synthesis of gold nanoparticles (NPs) from aqueous solutions of dilute Au(III) salts by a living green marine seaweed (Ulva armoricana) is reported for the first time. NPs synthesis using typical procedures have many associated environmental hazards. The reported methods involve green, nontoxic, eco-friendly synthetic procedures. The formation of AuNPs was extremely rapid (~15 minutes) following illumination of the living U. armoricana, while the rate of NP formation in the dark was very slow (over 2 weeks)...
November 22, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29162137/potentiating-angiogenesis-arrest-in-vivo-via-laser-irradiation-of-peptide-functionalised-gold-nanoparticles
#9
Pedro Pedrosa, Amelie Heuer-Jungemann, Antonios G Kanaras, Alexandra R Fernandes, Pedro V Baptista
BACKGROUND: Anti-angiogenic therapy has great potential for cancer therapy with several FDA approved formulations but there are considerable side effects upon the normal blood vessels that decrease the potential application of such therapeutics. Chicken chorioallantoic membrane (CAM) has been used as a model to study angiogenesis in vivo. Using a CAM model, it had been previously shown that spherical gold nanoparticles functionalised with an anti-angiogenic peptide can humper neo-angiogenesis...
November 21, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29161920/development-optimization-and-in-vitro-characterization-of-dasatinib-loaded-peg-functionalized-chitosan-capped-gold-nanoparticles-using-box-behnken-experimental-design
#10
Sandeep Kumar Reddy Adena, Mansi Upadhyay, Harsh Vardhan, Brahmeshwar Mishra
OBJECTIVE: The purpose of this research study was to develop, optimize, and characterize dasatinib loaded polyethylene glycol (PEG) stabilized chitosan capped gold nanoparticles (DSB-PEG-Ch-GNPs). METHODS: Gold (III) chloride hydrate was reduced with chitosan and the resulting nanoparticles were coated with thiol-terminated PEG and loaded with dasatinib (DSB). Plackett-Burman design (PBD) followed by Box-Behnken experimental design (BBD) were employed to optimize the process parameters...
November 21, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29161496/ion-transport-across-biological-membranes-by-carborane-capped-gold-nanoparticles
#11
Marcin P Grzelczak, Stephen P Danks, Robert C Klip, Domagoj Belic, Adnana Zaulet, Casper Kunstmann-Olsen, Dan F Bradley, Tatsuya Tsukuda, Clara Viñas, Francesc Teixidor, Jonathan J Abramson, Mathias Brust
2-3 nm carborane-capped gold nanoparticles (Au/carborane NPs) can act as artificial ion transporters across biological membranes. The particles themselves are large hydrophobic anions that have the ability to disperse in aqueous media and to partition over both sides of a phospholipid bilayer membrane. Their presence therefore causes a membrane potential that is determined by the relative concentrations of particles on each side of the membrane according to the Nernst-Equation. The particles tend to adsorb to both sides of the membrane and can flip across if changes in membrane potential require their repartitioning...
November 21, 2017: ACS Nano
https://www.readbyqxmd.com/read/29161215/recent-advances-in-nanomedicine-and-survivin-targeting-in-brain-cancers
#12
Jake Mazur, Kislay Roy, Jagat R Kanwar
Brain cancer is a highly lethal disease, especially devastating toward both the elderly and children. This cancer has no therapeutics available to combat it, predominately due to the blood-brain barrier (BBB) preventing treatments from maintaining therapeutic levels within the brain. Recently, nanoparticle technology has entered the forefront of cancer therapy due to its ability to deliver therapeutic effects while potentially passing physiological barriers. Key nanoparticles for brain cancer treatment include glutathione targeted PEGylated liposomes, gold nanoparticles, superparamagnetic iron oxide nanoparticles and nanoparticle-albumin bound drugs, with these being discussed throughout this review...
November 21, 2017: Nanomedicine
https://www.readbyqxmd.com/read/29161019/local-enhancement-of-lipid-membrane-permeability-induced-by-irradiated-gold-nanoparticles
#13
Andrea Torchi, Federica Simonelli, Riccardo Ferrando, Giulia Rossi
Photothermal therapies are based on the optical excitation of plasmonic nanoparticles in the biological environment. The effects of the irradiation on the biological medium depend critically on the heat transfer process at the nanoparticle interface, on the temperature reached by the tissues as well as on the spatial extent of temperature gradients. Unfortunately, both the temperature and its biological effects are difficult to be probed experimentally at the molecular scale. Here, we approach this problem using non-equilibrium molecular dynamics simulations...
November 21, 2017: ACS Nano
https://www.readbyqxmd.com/read/29160229/improved-localized-surface-plasmon-resonance-index-sensitivity-based-on-chemically-synthesized-gold-nanoparticles-on-indium-tin-oxide-surfaces
#14
Jin Zhu, Xiaolong Li, Wei Zheng, Biao Wang, Yubo Tian
The results of this reported work indicated that gold nanoparticles (Au NPs) arrays self-assembled on Indium Tin Oxide (ITO) glasses can obtain broader localized surface plasmon resonance (LSPR) wavelength range and higher sensitivity than the bare quartz. The results of surface electric field calculated using Finite Difference Time Domain (FDTD) showed that the electric field of nanoparticles on ITO glasses is enhanced and the repulsive forces within each particle is weakened. According to the dipolar interaction mechanism, a weakened repulsive forces within each particle lead to a lower resonance frequency and a strong redshift of the LSPR spectra...
November 21, 2017: Nanotechnology
https://www.readbyqxmd.com/read/29160029/dose-dependencies-and-biocompatibility-of-renal-clearable-gold-nanoparticles
#15
Jie Zheng, Jing Xu, Mengxiao Yu, Chuanqi Peng, Phoebe Carter, Jia Tian, Xuhui Ning, Qinhan Zhou, Qiu Tu, Greg Zhang, Anthony Dao, Xingya Jiang, Payal Kapur, Jer-Tsong Hsieh, Xudong Zhao, Pengyu Liu
While dose dependencies in pharmacokinetics and clearance are often observed in clinically used small molecules, very few studies have been dedicated to the understandings of potential dose-dependent in vivo transport of nanomedicines. Here we report that the pharmacokinetics and clearance of renal clearable gold nanoparticles (GS-AuNPs) are strongly dose-dependent once injection doses are above 15 mg/kg: high dose expedited the renal excretion and shortened the blood retention. As a result, the no-observed-adverse-effect-level (NOAEL) of GS-AuNPs was >1000 mg/kg in CD-1 mice...
November 20, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29159358/optical-manipulation-of-individual-strongly-absorbing-platinum-nanoparticles
#16
Akbar Samadi, Poul Martin Bendix, Lene B Oddershede
Nanostructures with exceptional absorption in the near infrared (NIR) regime are receiving significant attention due to their ability to promote controlled local heating in biological material upon irradiation. Also, such nano-structures have numerous applications in nano-electronics and for bio-exploration. Therefore, significant effort is being put into controlling and understanding plasmonic nanostructures. However, essentially all focus has been on NIR resonant gold nanoparticles and remarkably little attention has been given to nanoparticles of other materials that may have superior properties...
November 21, 2017: Nanoscale
https://www.readbyqxmd.com/read/29158842/locoregional-confinement-and-major-clinical-benefit-of-188-re-loaded-cxcr4-targeted-nanocarriers-in-an-orthotopic-human-to-mouse-model-of-glioblastoma
#17
Delphine Séhédic, Igor Chourpa, Clément Tétaud, Audrey Griveau, Claire Loussouarn, Sylvie Avril, Claire Legendre, Nicolas Lepareur, Didier Wion, François Hindré, François Davodeau, Emmanuel Garcion
PURPOSE: Gold standard beam radiation for glioblastoma (GBM) treatment is challenged by resistance phenomena occurring in cellular populations well prepared to survive or to repair damage caused by radiation. Among signals that have been linked with radio-resistance, the SDF1/CXCR4 axis, associated with cancer stem-like cell, may be an opportune target. To avoid the problem of systemic toxicity and blood-brain barrier crossing, the relevance and efficacy of an original system of local brain internal radiation therapy combining a radiopharmaceutical with an immuno-nanoparticle was investigated...
2017: Theranostics
https://www.readbyqxmd.com/read/29158837/temperature-sensitive-gold-nanoparticle-coated-pluronic-pll-nanoparticles-for-drug-delivery-and-chemo-photothermal-therapy
#18
Ying Sun, Qi Wang, Jianhua Chen, Lei Liu, Li Ding, Ming Shen, Jin Li, Baoshan Han, Yourong Duan
Gold nanoparticle-coated Pluronic-b-poly(L-lysine) nanoparticles (Pluronic-PLL@Au NPs) were synthesized via an easy one-step method and employed as carriers for the delivery of paclitaxel (PTX) in chemo-photothermal therapy, in which Pluronic-PLL acts as the reductant for the formation of AuNPs without the need for an additional reducing agent. METHODS: The deposition of AuNPs on the surface of Pluronic-PLL micelles and the thermal response of the system were followed via ultraviolet-visible spectroscopy and dynamic light scattering...
2017: Theranostics
https://www.readbyqxmd.com/read/29158823/engineered-zn-ii-dipicolylamine-gold-nanorod-provides-effective-prostate-cancer-treatment-by-combining-sirna-delivery-and-photothermal-therapy
#19
Kyung Hyun Min, Young-Hwa Kim, Zhantong Wang, Jihoon Kim, Jee Seon Kim, Sun Hwa Kim, Kwangmeyung Kim, Ick Chan Kwon, Dale O Kiesewetter, Xiaoyuan Chen
Combination cancer treatment has emerged as a critical approach to achieve remarkable anticancer effect. In this study, we prepared a theranostic nanoformulation that allows for photoacoustic imaging as well as combination gene and photothermal therapy. Gold nanorods (GNR) were coated with dipicolyl amine (DPA), which forms stable complexes with Zn(2+) cations. The resulting nanoparticles, Zn(II)/DPA-GNR, recognize phosphate-containing molecules, including siRNA, because of the specific interaction between Zn(II) and the phosphates...
2017: Theranostics
https://www.readbyqxmd.com/read/29158393/dynamics-and-control-of-gold-encapped-gallium-arsenide-nanowires-imaged-by-4d-electron-microscopy
#20
Bin Chen, Xuewen Fu, Jau Tang, Mykhaylo Lysevych, Hark Hoe Tan, Chennupati Jagadish, Ahmed H Zewail
Eutectic-related reaction is a special chemical/physical reaction involving multiple phases, solid and liquid. Visualization of a phase reaction of composite nanomaterials with high spatial and temporal resolution provides a key understanding of alloy growth with important industrial applications. However, it has been a rather challenging task. Here, we report the direct imaging and control of the phase reaction dynamics of a single, as-grown free-standing gallium arsenide nanowire encapped with a gold nanoparticle, free from environmental confinement or disturbance, using four-dimensional (4D) electron microscopy...
November 20, 2017: Proceedings of the National Academy of Sciences of the United States of America
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