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https://www.readbyqxmd.com/read/28241431/the-role-of-carbohydrate-response-element-binding-protein-in-intestinal-and-hepatic-fructose-metabolism
#1
REVIEW
Katsumi Iizuka
Many articles have discussed the relationship between fructose consumption and the incidence of obesity and related diseases. Fructose is absorbed in the intestine and metabolized in the liver to glucose, lactate, glycogen, and, to a lesser extent, lipids. Unabsorbed fructose causes bacterial fermentation, resulting in irritable bowl syndrome. Therefore, understanding the mechanisms underlying intestinal and hepatic fructose metabolism is important for the treatment of metabolic syndrome and fructose malabsorption...
February 22, 2017: Nutrients
https://www.readbyqxmd.com/read/28241419/the-effects-of-iodine-fortified-milk-on-the-iodine-status-of-lactating-mothers-and-infants-in-an-area-with-a-successful-salt-iodization-program-a-randomized-controlled-trial
#2
Pantea Nazeri, Parvin Mirmiran, Zhale Tahmasebinejad, Mehdi Hedayati, Hossein Delshad, Fereidoun Azizi
Iodine deficiency during the first two years of life may cause irreversible brain damage and mental retardation. The aim of the present study was to investigate, for the first time, the effect of iodine fortified milk on the iodine status of lactating mothers and their infants. In this multicenter randomized controlled trial, 84 lactating mother-infant pairs from health care centers were randomly selected. After meeting the inclusion criteria, lactating mothers were randomly assigned to two groups: the iodine fortified milk group and the control group (n = 42 each)...
February 22, 2017: Nutrients
https://www.readbyqxmd.com/read/28241416/determination-of-inorganic-cations-and-anions-in-chitooligosaccharides-by-ion-chromatography-with-conductivity-detection
#3
Lidong Cao, Xiuhuan Li, Li Fan, Li Zheng, Miaomiao Wu, Shanxue Zhang, Qiliang Huang
Chitooligosaccharides (COSs) are a promising drug candidate and food ingredient because they are innately biocompatible, non-toxic, and non-allergenic to living tissues. Therefore, the impurities in COSs must be clearly elucidated and precisely determined. As for COSs, most analytical methods focus on the determination of the average degrees of polymerization (DPs) and deacetylation (DD), as well as separation and analysis of the single COSs with different DPs. However, little is known about the concentrations of inorganic cations and anions in COSs...
February 22, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28240707/comparison-of-different-methods-for-the-swimming-aerobic-capacity-evaluation
#4
Jailton Gregório Pelarigo, Ricardo Jorge Fernandes, João Ribeiro, Benedito Sérgio Denadai, Camila Coelho Greco, João Paulo Vilas-Boas
This study compared velocity (v) and bioenergetical factors using different methods applied for the swimming aerobic capacity evaluation. Ten elite female swimmers (17.6 ± 1.9 yrs., 1.70 ± 0.05 m and 61.3 ± 5.8 kg) performed an intermittent incremental velocity protocol until voluntary exhaustion to determine the v associated to the individual anaerobic threshold (IAnT), ventilatory threshold (VT), heart rate threshold (HRT), lactate threshold fixed in 3.5 mmol.L (LT3.5) and maximal oxygen uptake (V[Combining Dot Above]O2max)...
February 23, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28240296/exogenous-melatonin-reduces-somatic-cell-count-of-milk-in-holstein-cows
#5
Minghui Yang, Jianmin Shi, Jianhua Tian, Jingli Tao, Menglong Chai, Jing Wang, Zhiyuan Xu, Yukun Song, Kuanfeng Zhu, Pengyun Ji, Guoshi Liu
High somatic cell counts in milk caused by mastitis significantly influence the quality of milk and result in substantial annual economic loss. This study evaluated the beneficial effects of melatonin (MT) on milk somatic cell count (SCC) in cows. To examine the effects of melatonin on SCC, one hundred twenty cows were divided into four groups based on milk SCC. In each group, half of the cows were treated with melatonin (S.C.). Melatonin treatment significantly reduced milk SCC. To explore the potential mechanism, 20 cows with relatively high SCC were selected to evaluate the biochemical and immunological profiles of their blood after melatonin treatment...
February 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28239993/maternal-betaine-supplementation-in-rats-induces-intergenerational-changes-in-hepatic-igf-1-expression-and-dna-methylation
#6
Nannan Zhao, Shu Yang, Yun Hu, Haibo Dong, Ruqian Zhao
SCOPE: Betaine is widely used in animal nutrition to promote growth. Here we aimed to investigate whether maternal betaine supplementation during pregnancy can exert multigenerational effects on growth across two generations and the possible epigenetic modifications associated to such effects. METHODS AND RESULTS: In this study, 3-month-old female Sprague-Dawley rats were fed diet supplemented with 1% betaine throughout the pregnancy and lactation. Betaine-supplemented dams produced bigger litter but smaller F1 pups at birth and weaning...
February 26, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28239846/inhibition-of-6-phosphofructo-2-kinase-suppresses-fibroblast-like-synoviocytes-mediated-synovial-inflammation-and-joint-destruction-in-rheumatoid-arthritis
#7
Yaoyao Zou, Shan Zeng, Mingcheng Huang, Qian Qiu, Youjun Xiao, Maohua Shi, Zhongping Zhan, Liuqin Liang, Xiuyan Yang, Hanshi Xu
BACKGROUND AND PURPOSE: Abnormal glycolytic metabolism contributes to joint inflammation in rheumatoid arthritis (RA). The aims of this study were to investigate the role of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3), a bifunctional enzyme that controls the glycolytic rate, in regulating fibroblast-like synoviocyte (FLS)-mediated synovial inflammation and invasiveness in RA. EXPERIMENTAL APPROACH: A specific PFKFB3 inhibitor, PFK15, and siRNA were used to evaluate the role of PFKFB3...
February 27, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28239468/immunotherapy-associated-autoimmune-hemolytic-anemia
#8
Uqba Khan, Farman Ali, Muhammad Siddique Khurram, Awais Zaka, Tarik Hadid
BACKGROUND: Immunotherapy has been widely used in the treatment of several solid and hematologic malignancies. Checkpoint inhibitors have been the forefront of cancer immunotherapy in recent years. Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed cell death 1 (PD-1) pathway are the prototypic checkpoint targets for immunotherapy. When combined, CTLA-4 and PD-1 checkpoint inhibitors work synergistically, but with increased probability of toxicity. The following case represents an unusual adverse effect of combined treatment with ipilimumab and nivolumab used for treatment of metastatic melanoma...
2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/28239403/lipid-overload-during-gestation-and-lactation-can-independently-alter-lipid-homeostasis-in-offspring-and-promote-metabolic-impairment-after-new-challenge-to-high-fat-diet
#9
Laís Angélica de Paula Simino, Thaís de Fante, Marina Figueiredo Fontana, Fernanda Oliveira Borges, Márcio Alberto Torsoni, Marciane Milanski, Lício Augusto Velloso, Adriana Souza Torsoni
BACKGROUND: Nutritional status in early life is critically involved in the metabolic phenotype of offspring. However the changes triggered by maternal consumption of high-fat diet (HFD) in pre- or postnatal period should be better understood. Here we evaluated whether maternal HFD consumption during gestation and lactation could differently affect liver miR-122 and miR-370 expression leading to metabolic damages observed in offspring. Moreover, we investigate whether early overnutrition program offspring to more harmful response to HFD in later life...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/28239322/intestinal-barrier-integrity-and-function-in-infants-with-cholestasis
#10
Nagla H Abu Faddan, Tahra M K Sherif, Omnia A Mohammed, Khalid A Nasif, Ebtesam M El Gezawy
BACKGROUND/AIMS: The safety of the human body is maintained by effective monitoring of the mucosal surface integrity and protection against potentially harmful compounds. This function of the gut called intestinal barrier function can be affected by cholestasis and the absence of bile in the intestinal lumen. We aimed to determine whether the gut barrier integrity is impaired in infants with cholestasis by evaluation of the intestinal fatty acid binding proteins (I-FABP) and ileal bile acid binding protein (I-BABP) as markers of intestinal epithelial cell damage and plasma D-lactate level as a marker of gut wall permeability...
January 2017: Intestinal Research
https://www.readbyqxmd.com/read/28239030/metabolic-profiling-of-gemcitabine-and-paclitaxel-treated-immortalized-human-pancreatic-cell-lines-with-k-ras-g12d
#11
Akiko Todaka, Rina Umehara, Keiko Sasaki, Masakuni Serizawa, Kenichi Urakami, Masatoshi Kusuhara, Ken Yamaguchi, Hirofumi Yasui
The mechanisms of action of gemcitabine (GEM) and paclitaxel (PTX) have been well investigated, and shown to be the inhibition of DNA polymerase and polymerization of tubulin, respectively. Meanwhile, genomic research has revealed that mutations in the K-RAS oncogene occur in over 90% of pancreatic cancer. Oncogenic alteration rewires alternative metabolic pathways to satisfy the demands of growth. The K-RAS oncogene also has been shown to upregulate glycolysis and glutaminolysis. However, it is still unclear whether K-RAS independently plays a central role in controlling tumor metabolism...
2017: Biomedical Research
https://www.readbyqxmd.com/read/28238905/seasonal-heat-stress-affects-adipose-tissue-proteome-toward-enrichment-of-the-nrf2-mediated-oxidative-stress-response-in-late-pregnant-dairy-cows
#12
M Zachut, G Kra, L Livshitz, Y Portnick, S Yakoby, G Friedlander, Y Levin
: Environmental heat stress and metabolic stress during transition from late gestation to lactation are main factors limiting production in dairy cattle, and there is a complex interaction between them. Many proteins expressed in adipose tissue are involved in metabolic responses to stress. We aimed to investigate the effects of seasonal heat stress on adipose proteome in late-pregnant cows, and to identify biomarkers of heat stress. Late pregnant cows during summer heat stress (S, n=18), or during the winter season (W, n=12) were used...
February 23, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28238832/the-energetic-physiological-and-behavioral-response-of-lemon-sharks-negaprion-brevirostris-to-simulated-longline-capture
#13
Ian A Bouyoucos, Cory D Suski, John W Mandelman, Edward J Brooks
Commercial fisheries bycatch is a considerable threat to elasmobranch population recovery, and techniques to mitigate sub-lethal consequences can be improved with data on the energetic, physiological, and behavioral response of individuals to capture. This study sought to estimate the effects of simulated longline capture on the behavior, energy use, and physiological stress of juvenile lemon sharks (Negaprion brevirostris). Captive sharks equipped with acceleration biologgers were subjected to one hour of simulated longline capture...
February 23, 2017: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/28238779/daily-activity-rhythms-and-the-stress-related-response-in-the-wedge-sole-dicologoglossa-cuneata-moreau-1881
#14
E De la Roca, B Sánchez, J M López, M A Herves, A Canalejo, M Herrera
To gain further insights on the wedge sole (Dicologoglossa cuneata Moreau, 1881) physiology and behavior, we evaluated its daily feeding and locomotor activity rhythms and compared three different feeding strategies: self-feeding (SF), diurnal feeding schedule (DS) and nocturnal feeding schedule (NS). 450 fish divided into three groups (three replicates each), were kept during 65days. SF had free access to self-feeders whereas DS and NS were fed four times a day. Physiological stress parameters as plasma cortisol, glucose, lactate, proteins and triglycerides were determined...
February 23, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28238530/a-membrane-associated-adenylate-cyclase-modulates-lactate-dehydrogenase-and-creatine-kinase-activities-required-for-bull-sperm-capacitation-induced-by-hyaluronic-acid
#15
Silvina Fernández, Mariana Córdoba
Hyaluronic acid, as well as heparin, is a glycosaminoglycan present in the female genital tract of cattle. The aim of this study was to evaluate oxidative metabolism and intracellular signals mediated by a membrane-associated adenylate cyclase (mAC), in sperm capacitation with hyaluronic acid and heparin, in cryopreserved bull sperm. The mAC inhibitor, 2',5'-dideoxyadenosine, was used in the present study. Lactate dehydrogenase (LDH) and creatine kinase (CK) activities and lactate concentration were determined spectrophotometrically in the incubation medium...
February 20, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/28238490/composition-of-single-step-media-used-for-human-embryo-culture
#16
Dean E Morbeck, Nikola A Baumann, Devin Oglesbee
OBJECTIVE: To determine compositions of commercial single-step culture media and test with a murine model whether differences in composition are biologically relevant. DESIGN: Experimental laboratory study. SETTING: University-based laboratory. ANIMAL(S): Inbred female mice were superovulated and mated with outbred male mice. INTERVENTION(S): Amino acid, organic acid, and ions content were determined for single-step culture media: CSC, Global, G-TL, and 1-Step...
February 23, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28238410/histological-and-immunohistochemical-characterization-of-the-mongolian-gerbil-s-mammary-gland-during-gestation-lactation-and-involution
#17
Ellen C R Leonel, Luiz R Falleiros, Silvana G P Campos, Sebastião R Taboga
The morphological description of normal tissues is fundamental for making comparisons and in order to identify injuries and lesions. The aim of this work was to describe the morphological characteristics of the female Mongolian gerbil's (Meriones unguiculatus) normal mammary gland, the average expression of hormone receptors, and the average proliferation rates in the epithelial cells during the periods of lactation, pregnancy and involution. Dams were euthanized on the 14th and 21st gestational days, 7 and 14days after parturition, and 3 and 5days after weaning...
February 23, 2017: Acta Histochemica
https://www.readbyqxmd.com/read/28237799/neuroprotective-effects-of-genistein-3-sodium-sulfonate-on-focal-cerebral-ischemia-in-rats
#18
Liangdong Li, Jinghua Xue, Ruizhen Liu, Xiao Li, Lijuan Lai, Jiali Xie, Zhihua Huang, Cheng Huang
In order to improve the poor water solubility of genistein (4', 5, 7-trihydroxyisoflavone), which is extracted from food sources such as tofu, soybeans, and kudzu, we sulfonated genistein to synthesize a relatively more water-soluble compound, namely genistein-3'-sodium sulfonate (GSS). Our previous studies demonstrate that GSS protects cortical neurons from injury induced by focal cerebral ischemia. However, the molecular mechanisms underlying this protective effect remain unclear. We aimed to investigate the protective effect and potential molecular mechanisms of action of GSS in rat glutamate-induced cortical neuron injury in vitro and middle cerebral artery occlusion (MCAO) in vivo models...
February 22, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28237652/impact-of-epinephrine-contained-in-local-anesthetic-solution-on-serum-lactate-level-during-orthognathic-surgery
#19
Hidetaka Kuroda, Gaku Kawamura, Manabu Soya, Takayuki Kitamura, Tatsuya Ichinohe, Yoshitsugu Yamada
PURPOSE: There have been many discussions of a relation between endogenous and exogenous epinephrine and hyperlactatemia. This study aimed to identify the impact of epinephrine contained in a local anesthetic solution on serum lactate levels in patients who underwent orthognathic surgery. MATERIALS AND METHODS: This study was a retrospective record review of cases of maxillary and mandibular osteotomy at the Tokyo University Hospital (Tokyo, Japan) from January 2006 through December 2014...
February 3, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28237602/effects-of-intramuscular-injections-of-folic-acid-vitamin-b12-or-both-on-lactational-performance-and-energy-status-of-multiparous-dairy-cows
#20
M Duplessis, H Lapierre, D Pellerin, J-P Laforest, C L Girard
The purpose of this experiment was to gain understanding on changes in energy partitioning when folic acid and vitamin B12 supplements, alone or combined, were given by weekly intramuscular injections from 3 wk before the expected calving date until 7 wk postpartum. Twenty-four multiparous cows were assigned to 6 blocks of 4 cows each according to previous 305-d lactation yield to either 0 or 320 mg of folic acid and 0 or 10 mg of vitamin B12 in a 2 × 2 factorial arrangement. Plasma concentration of folates was increased by folic acid supplement, and this increase was greater with the combined supplement...
February 22, 2017: Journal of Dairy Science
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