keyword
MENU ▼
Read by QxMD icon Read
search

host-pathogen

keyword
https://www.readbyqxmd.com/read/29148885/self-clearance-of-pestivirus-in-a-pyrenean-chamois-rupicapra-pyrenaica-population
#1
Emmanuelle Gilot-Fromont, Mathieu Garel, Philippe Gibert, Sébastien Lambert, Pierre Menaut, Brigitte Bonetti, Yvette Game, Gaël Reynaud, Kévin Foulché
Understanding the dynamics of host-pathogen interaction is key to the management of epidemics. A pestivirus belonging to the border disease virus group 4 emerged around 2001 in Pyrenean chamois (Rupicapra pyrenaica) in Spain and France. The virus had significant demographic impact in some populations, but it was less harmful and more endemic in other places. The determinants of these local variations are still unclear. Here, we documented empirical evidence of self-clearance of the virus in a chamois population in France...
November 17, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/29147504/immuno-targeting-of-staphylococcus-aureus-via-surface-remodeling-complexes
#2
Mary J Sabulski, Sean E Pidgeon, Marcos M Pires
Agents with novel mechanisms of action are needed to complement traditional antibiotics. Towards these goals, we have exploited the surface-homing properties of vancomycin to tag the surface of Gram-positive pathogens with immune cell attractants in two unique modes. First, vancomycin was conjugated to the small molecule hapten 2,4-dinitrophenol (DNP) to promote bacterial opsonization. Second, we built on these results by improving the tagging specificity and mechanism of incorporation by coupling it to a sortase A substrate peptide...
October 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/29146500/motility-biofilm-formation-apoptotic-effect-and-virulence-gene-expression-of-atypical-salmonella-typhimurium-outside-and-inside-caco-2-cells
#3
Ibtissem Chakroun, Abdelkarim Mahdhi, Patricia Morcillo, Hector Cordero, Alberto Cuesta, Amina Bakhrouf, Kacem Mahdouani, M Ángeles Esteban
Disease outbreaks related to waterborne pathogen contamination throughout the world as well as challenges that lie ahead for addressing persistent infection are of renewed interest. In this research, we studied the effects of prolonged exposure of Salmonella enterica serovar Typhimurium to the cues encountered in the extracellular environment particularly in seawater microcosm on bacterial virulence and subsequent infection in Caco-2 cells. Our data show a significant difference in biofilm formation, swimming and swarming motilities between normal and stressed cells of S...
November 13, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29142017/modelling-the-effects-of-phylogeny-and-body-size-on-within-host-pathogen-replication-and-immune-response
#4
Soumya Banerjee, Alan S Perelson, Melanie Moses
Understanding how quickly pathogens replicate and how quickly the immune system responds is important for predicting the epidemic spread of emerging pathogens. Host body size, through its correlation with metabolic rates, is theoretically predicted to impact pathogen replication rates and immune system response rates. Here, we use mathematical models of viral time courses from multiple species of birds infected by a generalist pathogen (West Nile Virus; WNV) to test more thoroughly how disease progression and immune response depend on mass and host phylogeny...
November 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/29141986/arfgap1-restricts-mycobacterium-tuberculosis-entry-by-controlling-the-actin-cytoskeleton
#5
Ok-Ryul Song, Christophe J Queval, Raffaella Iantomasi, Vincent Delorme, Sabrina Marion, Romain Veyron-Churlet, Elisabeth Werkmeister, Michka Popoff, Isabelle Ricard, Samuel Jouny, Nathalie Deboosere, Frank Lafont, Alain Baulard, Edouard Yeramian, Laurent Marsollier, Eik Hoffmann, Priscille Brodin
The interaction of Mycobacterium tuberculosis (Mtb) with pulmonary epithelial cells is critical for early stages of bacillus colonization and during the progression of tuberculosis. Entry of Mtb into epithelial cells has been shown to depend on F-actin polymerization, though the molecular mechanisms are still unclear. Here, we demonstrate that mycobacterial uptake into epithelial cells requires rearrangements of the actin cytoskeleton, which are regulated by ADP-ribosylation factor 1 (Arf1) and phospholipase D1 (PLD1), and is dependent on the M3 muscarinic receptor (M3R)...
November 15, 2017: EMBO Reports
https://www.readbyqxmd.com/read/29140982/development-standardization-and-testing-of-a-bacterial-wound-infection-model-based-on-ex-vivo-human-skin
#6
Christoph Schaudinn, Christin Dittmann, Jana Jurisch, Michael Laue, Nazende Günday-Türeli, Ulrike Blume-Peytavi, Annika Vogt, Fiorenza Rancan
Current research on wound infections is primarily conducted on animal models, which limits direct transferability of these studies to humans. Some of these limitations can be overcome by using-otherwise discarded-skin from cosmetic surgeries. Superficial wounds are induced in fresh ex vivo skin, followed by intradermal injection of Pseudomonas aeruginosa under the wound. Subsequently, the infected skin is incubated for 20 hours at 37°C and the CFU/wound are determined. Within 20 hours, the bacteria count increased from 107 to 109 bacteria per wound, while microscopy revealed a dense bacterial community in the collagen network of the upper wound layers as well as numerous bacteria scattered in the dermis...
2017: PloS One
https://www.readbyqxmd.com/read/29139177/a-structural-overview-of-mycobacterial-adhesins-key-biomarkers-for-diagnostics-and-therapeutics
#7
REVIEW
Flavia Squeglia, Alessia Ruggiero, Alfonso De Simone, Rita Berisio
Adherence, colonization, and survival of mycobacteria in host cells require surface adhesins, which are attractive pharmacotherapeutic targets. A large arsenal of pilus and non-pilus adhesins have been identified in mycobacteria. These adhesins are capable of interacting with host cells, including macrophages and epithelial cells and are essential to microbial pathogenesis. In the last decade, several structures of mycobacterial adhesins responsible for adhesion to either macrophages or extra cellular matrix proteins have been elucidated...
November 15, 2017: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/29137933/cd4-t-cell-differentiation-in-chronic-viral-infections-the-tfh-perspective
#8
REVIEW
Laura A Vella, Ramin S Herati, E John Wherry
CD4(+) T cells play a critical role in the response to chronic viral infections during the acute phase and in the partial containment of infections once chronic infection is established. As infection persists, the virus-specific CD4(+) T cell response begins to shift in phenotype. The predominant change described in both mouse and human studies of chronic viral infection is a decrease in detectable T helper type (Th)1 responses. Some Th1 loss is due to decreased proliferative potential and decreased cytokine production in the setting of chronic antigen exposure...
November 11, 2017: Trends in Molecular Medicine
https://www.readbyqxmd.com/read/29134096/co-infection-does-not-predict-disease-signs-in-gopherus-tortoises
#9
Chava L Weitzman, Ryan Gov, Franziska C Sandmeier, Sarah J Snyder, C Richard Tracy
In disease ecology, the host immune system interacts with environmental conditions and pathogen properties to affect the impact of disease on the host. Within the host, pathogens may interact to facilitate or inhibit each other's growth, and pathogens interact with different hosts differently. We investigated co-infection of two Mycoplasma and the association of infection with clinical signs of upper respiratory tract disease in four congeneric tortoise host species (Gopherus) in the United States to detect differences in infection risk and disease dynamics in these hosts...
October 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/29133871/exploration-of-antifungal-and-immunomodulatory-potentials-of-a-furanone-derivative-to-rescue-disseminated-cryptococosis-in-mice
#10
Sudarshan Singh Rathore, Muthukrishnan Isravel, Sridharan Vellaisamy, David Raj Chellappan, Lalitha Cheepurupalli, Thiagarajan Raman, Jayapradha Ramakrishnan
Cryptococcus neoformans infection is quite complex with both host-pathogen interaction and host immune profile determining disease progress and therapeutic outcome. Hence in the present study, the potential utility of (E)-5-benzylidenedihydrofuran-2(3 H)-one (compound-6) was explored as an effective anticryptococcal compound with immunomodulatory potential. The efficacy of compound-6 in pulmonary cryptococosis model using H99 strain was investigated. The effective dose was found to provide 100% survival, with a significant reduction of yeast burden in lungs and brain...
November 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29133349/the-role-of-calprotectin-in-withholding-zinc-and-copper-from-candida-albicans
#11
Angelique N Besold, Benjamin A Gilston, Jana N Radin, Christian Ramsoomair, Edward M Culbertson, Cissy X Li, Brendan P Cormack, Walter J Chazin, Thomas E Kehl-Fie, Valeria C Culotta
The opportunistic fungal pathogen Candida albicans acquires essential metals from the host, yet the host can sequester these micronutrients through a process known as nutritional immunity. How the host withholds metals from C. albicans was poorly understood and here we examine the role of calprotectin (CP), a transition metal binding protein. When CP depletes bioavailable Zn from the extracellular environment, C. albicans strongly upregulates ZRT1 and PRA1 for Zn import and maintains constant intracellular Zn through numerous cell divisions...
November 13, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/29132435/vasculotide-reduces-pulmonary-hyperpermeability-in-experimental-pneumococcal-pneumonia
#12
Birgitt Gutbier, Xiaohui Jiang, Kristina Dietert, Carolin Ehrler, Jasmin Lienau, Paul Van Slyke, Harold Kim, Van C Hoang, Jason T Maynes, Daniel J Dumont, Achim D Gruber, Norbert Weissmann, Timothy J Mitchell, Norbert Suttorp, Martin Witzenrath
BACKGROUND: Community-acquired pneumonia (CAP) is a significant cause of morbidity and mortality worldwide. Despite effective antimicrobial therapy, CAP can induce pulmonary endothelial hyperpermeability resulting in life-threatening lung failure due to an exaggerated host-pathogen interaction. Treatment of acute lung injury is mainly supportive because key elements of inflammation-induced barrier disruption remain undetermined. Angiopoietin-1 (Ang-1)-mediated Tie2 activation reduces, and the Ang-1 antagonist Ang-2 increases, inflammation and endothelial permeability in sepsis...
November 13, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29129280/daily-temperature-variation-and-extreme-high-temperatures-drive-performance-and-biotic-interactions-in-a-warming-world
#13
REVIEW
Robby Stoks, Julie Verheyen, Marie Van Dievel, Nedim Tüzün
We review the major patterns on the effects of daily temperature variation (DTV) and extreme high temperatures (EXT) on performance traits and the resulting outcome of biotic interactions in insects. EXT profoundly affects the outcome of all types of biotic interactions: competitive, predator-prey, herbivore-plant, host-pathogen/parasitoid and symbiotic interactions. Studies investigating effects of DTV on biotic interactions are few but also show strong effects on competitive and host-pathogen/parasitoid interactions...
October 2017: Current Opinion in Insect Science
https://www.readbyqxmd.com/read/29128932/atomic-force-microscopy-a-promising-tool-for-deciphering-the-pathogenic-mechanisms-of-fungi-in-cystic-fibrosis
#14
Stéphane Cuenot, Jean-Philippe Bouchara
During the past decades, atomic force microscopy (AFM) has emerged as a powerful tool in microbiology. Although most of the works concerned bacteria, AFM also permitted major breakthroughs in the understanding of physiology and pathogenic mechanisms of some fungal species associated with cystic fibrosis. Complementary to electron microscopies, AFM offers unprecedented insights to visualize the cell wall architecture and components through three-dimensional imaging with nanometer resolution and to follow their dynamic changes during cell growth and division or following the exposure to drugs and chemicals...
November 11, 2017: Mycopathologia
https://www.readbyqxmd.com/read/29127997/editorial-overview-offence-is-the-best-defense-host-pathogen-interactions-driving-evolution-of-human-immunity-and-the-germs-we-live-with
#15
EDITORIAL
Marc Pellegrini, Elizabeth Hartland
No abstract text is available yet for this article.
October 2017: Current Opinion in Immunology
https://www.readbyqxmd.com/read/29126967/effects-of-temperature-and-salinity-on-prevalence-and-intensity-of-infection-of-blue-crabs-callinectes-sapidus-by-vibrio-cholerae-v-parahaemolyticus-and-v-vulnificus-in-louisiana
#16
Timothy J Sullivan, Joseph E Neigel
Coastal marine and estuarine environments are experiencing higher average temperatures, greater frequency of extreme temperature events, and altered salinities. These changes are expected to stress organisms and increase their susceptibility to infectious diseases. However, beyond these generalities, little is known about how environmental factors influence host-pathogen relationships in the marine realm. We investigated the prevalence and intensity of infections by Vibrio cholerae, V. parahaemolyticus, and V...
November 7, 2017: Journal of Invertebrate Pathology
https://www.readbyqxmd.com/read/29124040/cold-shock-domain-family-proteins-csps-are-involved-in-regulation-of-virulence-cellular-aggregation-and-flagella-based-motility-in-listeria-monocytogenes
#17
Athmanya K Eshwar, Claudia Guldimann, Anna Oevermann, Taurai Tasara
Cold shock-domain family proteins (Csps) are highly conserved nucleic acid binding proteins regulating the expression of various genes including those involved in stress resistance and virulence in bacteria. We show here that Csps are involved in virulence, cell aggregation and flagella-based extracellular motility of Listeria monocytogenes. A L. monocytogenes mutant deleted in all three csp genes (ΔcspABD) is attenuated with respect to human macrophage infection as well as virulence in a zebrafish infection model...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29121973/in-vitro-investigations-on-extracellular-proteins-secreted-by-aphanomyces-invadans-the-causative-agent-of-epizootic-ulcerative-syndrome
#18
Muhammad Majeed, Gokhlesh Kumar, Sarah Schlosser, Mansour El-Matbouli, Mona Saleh
BACKGROUND: Proteases produced by many microorganisms, including oomycetes, are crucial for their growth and development. They may also play a critical role in disease manifestation. Epizootic ulcerative syndrome is one of the most destructive fish diseases known. It is caused by the oomycete Aphanomyces invadans and leads to mass mortalities of cultured and wild fish in many countries. The areas of concern are Australia, China, Japan, South and Southeast Asian countries and the USA. Extracellular proteases produced by this oomycete are believed to trigger EUS pathogenesis in fish...
November 9, 2017: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/29121928/a-yeast-two-hybrid-system-for-the-screening-and-characterization-of-small-molecule-inhibitors-of-protein-protein-interactions-identifies-a-novel-putative-mdm2-binding-site-in-p53
#19
Jin Huei Wong, Mohammad Alfatah, Mei Fang Sin, Hong May Sim, Chandra S Verma, David P Lane, Prakash Arumugam
BACKGROUND: Protein-protein interactions (PPIs) are fundamental to the growth and survival of cells and serve as excellent targets to develop inhibitors of biological processes such as host-pathogen interactions and cancer cell proliferation. However, isolation of PPI inhibitors is extremely challenging. While several in vitro assays to screen for PPI inhibitors are available, they are often expensive, cumbersome, and require large amounts of purified protein. In contrast, limited in vivo assays are available to screen for small-molecule inhibitors of PPI...
November 9, 2017: BMC Biology
https://www.readbyqxmd.com/read/29116636/pe-and-ppe-genes-a-tale-of-conservation-and-diversity
#20
Giovanni Delogu, Michael J Brennan, Riccardo Manganelli
PE and PPE are two large families of proteins typical of mycobacteria whose structural genes in the Mycobacterium tuberculosis complex (MTBC) occupy about 7% of the total genome. The most ancestral PE and PPE proteins are expressed by genes that belong to the same operon and in most cases are found inserted in the esx clusters, encoding a type VII secretion system. Duplication and expansion of pe and ppe genes, coupled with intragenomic and intergenomic recombination events, led to the emergence of the polymorphic pe_pgrs and ppe_mptr genes in the MTBC genome...
2017: Advances in Experimental Medicine and Biology
keyword
keyword
12555
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"