keyword
https://read.qxmd.com/read/38281357/meta-analysis-addressing-the-characterization-of-antibiotic-resistome-in-global-hospital-wastewater
#21
JOURNAL ARTICLE
Yutong Kang, Jie Wang, Zhenjun Li
Hospital wastewater (HWW) is a significant environmental reservoir of antibiotic resistance genes (ARGs). However, currently, no comprehensive understanding exists of the antibiotic resistome in global HWW. In this study, we attempted to address this knowledge gap through an in silico reanalysis of publicly accessible global HWW metagenomic data. We reanalyzed ARGs in 338 HWW samples from 13 countries in Africa, Asia, and Europe. In total, 2420 ARG subtypes belonging to 30 ARG types were detected, dominated by multidrug, beta-lactam, and aminoglycoside resistance genes...
January 20, 2024: Journal of Hazardous Materials
https://read.qxmd.com/read/38280321/deciphering-the-dynamics-and-driving-mechanisms-of-high-risk-antibiotic-resistome-in-size-fractionated-bacterial-community-during-drinking-water-chlorination-via-metagenomic-analysis
#22
JOURNAL ARTICLE
Shuya Wang, Yan Zhuang, Linjun Gao, Hongbin Huang, Xian Zhang, Shuyu Jia, Peng Shi, Xu-Xiang Zhang
To reveal the impact of chlorination on the high-risk resistome in size-fractionated bacterial community, we employed metagenomic approaches to decipher dynamics of high-risk antibiotic resistance genes (ARGs) and driving mechanisms in the free-living and particle-associated fractions within a full-scale drinking water treatment system. Our results revealed that chlorination significantly increased the relative abundance of high-risk ARGs in the free-living fraction to 0.33 ± 0.005 copies/cell (cpc), bacitracin and chloramphenicol resistance types were major contributors...
January 24, 2024: Journal of Hazardous Materials
https://read.qxmd.com/read/38276289/heat-pre-treatment-modified-host-and-non-host-interactions-of-powdery-mildew-with-barley-brassinosteroid-mutants-and-wild-types
#23
JOURNAL ARTICLE
Magdalena Rys, Diana Saja-Garbarz, József Fodor, Jakub Oliwa, Gábor Gullner, Csilla Juhász, Andrzej Kornaś, Andrzej Skoczowski, Damian Gruszka, Anna Janeczko, Balázs Barna
High temperatures associated with climate change may increase the severity of plant diseases. This study investigated the effect of heat shock treatment on host and non-host barley powdery mildew interactions using brassinosteroid (BR) mutants of barley. Brassinosteroids are plant steroid hormones, but so far little is known about their role in plant-fungal interactions. Wild type barley cultivar Bowman and its near-isogenic lines with disturbances in BR biosynthesis or signalling showed high compatibility to barley powdery mildew race A6, while cultivar Delisa and its BR-deficient mutants 522DK and 527DK were fully incompatible with this pathogen (host plant-pathogen interactions)...
January 22, 2024: Life
https://read.qxmd.com/read/38276028/integrated-genome-sequencing-and-transcriptome-analysis-identifies-candidate-pathogenicity-genes-from-ustilago-crameri
#24
JOURNAL ARTICLE
Juan Liang, Desuo Yin, Xinyue Shu, Ting Xiang, Chao Zhang, Honglian Li, Aijun Wang
Ustilago crameri is a pathogenic basidiomycete fungus that causes foxtail millet kernel smut (FMKS), a devastating grain disease in most foxtail-millet-growing regions of the world. Here, we report an assembled high-quality genome sequence of U. crameri strain SCZ-6 isolated from the diseased grains of foxtail millet in Changzhi, Shanxi Province, China. The genome size is 19.55 Mb, consisting of 73 contigs (N50 = 840,209 bp) with a G + C content of 54.09%, and encoding 6576 predicted genes and 6486 genes supported by RNA-seq...
January 21, 2024: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/38273771/metabolomics-approach-to-understand-molecular-mechanisms-involved-in-fungal-pathogen-citrus-pathosystems
#25
REVIEW
Evandro Silva, Rodolfo Dantas, Júlio César Barbosa, Roberto G S Berlinck, Taicia Fill
Citrus is a crucial crop with a significant economic impact globally. However, postharvest decay caused by fungal pathogens poses a considerable threat, leading to substantial financial losses. Penicillium digitatum , Penicillium italicum , Geotrichum citri-aurantii and Phyllosticta citricarpa are the main fungal pathogens, causing green mold, blue mold, sour rot and citrus black spot diseases, respectively. The use of chemical fungicides as a control strategy in citrus raises concerns about food and environmental safety...
January 26, 2024: Molecular Omics
https://read.qxmd.com/read/38273212/transcriptional-effects-of-carbon-and-nitrogen-starvation-on-ganoderma-boninense-an-oil-palm-phytopathogen
#26
JOURNAL ARTICLE
Jayanthi Nagappan, Siew-Eng Ooi, Kuang-Lim Chan, Faizun Kadri, Zain Nurazah, Mohd Amin Ab Halim, Lee Pei Lee Angel, Shamala Sundram, Chiew-Foan Chin, Sean T May, Eng Ti Leslie Low
BACKGROUND: Ganoderma boninense is a phytopathogen of oil palm, causing basal and upper stem rot diseases. METHODS: The genome sequence was used as a reference to study gene expression during growth in a starved carbon (C) and nitrogen (N) environment with minimal sugar and sawdust as initial energy sources. This study was conducted to mimic possible limitations of the C-N nutrient sources during the growth of G. boninense in oil palm plantations. RESULTS: Genome sequencing of an isolate collected from a palm tree in West Malaysia generated an assembly of 67...
January 25, 2024: Molecular Biology Reports
https://read.qxmd.com/read/38252233/ace-i-d-polymorphism-is-a-risk-factor-for-the-clinical-severity-of-covid-19-in-brazilian-male-patients
#27
JOURNAL ARTICLE
Sandro Soares Almeida, Marcos Fernandes Gregnani, Isabela Moreira Gontijo da Costa, Matheus Matias da Silva, Carolina Bonet Bub, Valmir Oliveira Silvino, Delio Eulalio Martins, Marcelo Wajchenberg
BACKGROUND: The renin-angiotensin system is potentially involved in the pathogen-host interaction in the disease caused by SARS-CoV-2, since the angiotensin-converting enzyme (ACE) 2 serves as a receptor for the virus. The impact of the pandemic in specific regions and ethnic groups highlights the importance of investigating genetic factors that disrupt the balance of the system in response to SARS-CoV-2 infection, especially in genes with ethnic frequency variations. Therefore, this study aimed to evaluate the influence of the ACE I/D polymorphism on the incidence and severity of COVID-19 in a sample of the Brazilian population...
January 22, 2024: Molecular Biology Reports
https://read.qxmd.com/read/38248981/molecular-signaling-and-metabolic-responses-during-the-interaction-between-human-keratinocytes-hacat-and-the-dermatophyte-trichophyton-rubrum
#28
JOURNAL ARTICLE
Monise Fazolin Petrucelli, Leonardo Martins-Santana, Antonio Rossi, Nilce Maria Martinez-Rossi
Trichophyton rubrum is the leading causative agent of dermatophytosis worldwide. Keratinocytes are the first line of defense that drives an immune response against fungal invasion. Host-specific pattern recognition receptors (PRRs) recognize pathogen-associated molecular patterns (PAMPs) to trigger immunological pathways. Fungal cell wall components are the primary sources of fungal PAMPs, and some pathogens increase cell wall rearrangement to evade the immune system. Glycolysis and enhanced lactate levels are critical for improving host immune responses to fungal infections...
January 16, 2024: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/38229327/distribution-of-antibiotic-resistance-genes-and-their-pathogen-hosts-in-duck-farm-environments-in-south-east-coastal-china
#29
JOURNAL ARTICLE
Kaidi Liu, Minge Wang, Yin Zhang, Chang Fang, Rongmin Zhang, Liangxing Fang, Jian Sun, Yahong Liu, Xiaoping Liao
Livestock farms are major reservoirs of antibiotic resistance genes (ARGs) that are discharged into the environment. However, the abundance, diversity, and transmission of ARGs in duck farms and its impact on surrounding environments remain to be further explored. Therefore, the characteristics of ARGs and their bacterial hosts from duck farms and surrounding environment were investigated by using metagenomic sequencing. Eighteen ARG types which consist of 823 subtypes were identified and the majority conferred resistance to multidrug, tetracyclines, aminoglycosides, chloramphenicols, MLS, and sulfonamides...
December 2024: Applied Microbiology and Biotechnology
https://read.qxmd.com/read/38205807/root-exudates-metabolic-profiling-confirms-distinct-defense-mechanisms-between-cultivars-and-treatments-with-beneficial-microorganisms-and-phosphonate-salts-against-verticillium-wilt-in-olive-trees
#30
JOURNAL ARTICLE
Eugenio Llorens, Ana López-Moral, Carlos Agustí-Brisach
Root exudates play a key role in the life cycle of Verticillium dahliae , the causal agent of Verticillium wilt diseases, since they induce microsclerotia germination to initiate plant infection through the roots. In olive plants, the genotype and the application of biological control agents (BCAs) or phosphonate salts influence the ability of root exudates to decrease V. dahliae viability. Understanding the chemical composition of root exudates could provide new insights into the mechanisms of olive plant defense against V...
January 11, 2024: Phytopathology
https://read.qxmd.com/read/38171431/microrna-transcriptome-analysis-reveals-the-immune-regulatory-mechanism-of-crassostrea-hongkongesis-against-vibrio-harveyi-infection
#31
JOURNAL ARTICLE
Yongkang Hou, Taoliang Liao, Fangqi Zhang, Teng Zhang, Lijun Wang, Wengang Lv, Zhimin Li
MicroRNAs (miRNAs) are small non-coding RNA molecules that modulate target-genes expression and play crucial roles in post-transcriptional regulation and immune system regulation. The Hong Kong oyster (Crassostrea hongkongesis), as the main marine aquaculture shellfish in the South China Sea, not only has high economic and ecological value, but also is an ideal model for conducting research on pathogen host interaction. Vibrio harveyi, a Gram negative luminescent marine bacterium, is widely distributed in coastal water environments and can cause large-scale death of C...
January 1, 2024: Fish & Shellfish Immunology
https://read.qxmd.com/read/38166632/high-quality-genome-resource-of-lasiodiplodia-pseudotheobromae-associated-with-die-back-on-eucalyptus-trees
#32
JOURNAL ARTICLE
LinQin Lu, GuoQing Li, FeiFei Liu
OBJECTIVES: Lasiodiplodia pseudotheobromae is an important fungal pathogen associated with die-back, canker and shoot blight in many plant hosts with a wide geographic distribution. The aim of our study was to provide high-quality genome assemblies and sequence annotation resources of L. pseudotheobromae, to facilitate future studies on the systematics, population genetics and genomics of the fungal pathogen L. pseudotheobromae. DATA DESCRIPTION: High-quality genomes of five L...
January 2, 2024: BMC genomic data
https://read.qxmd.com/read/38153818/gerwr-identifying-the-key-pathogenicity-associated-srnas-of-magnaporthe-oryzae-infection-in-rice-based-on-graph-embedding-and-random-walk-with-restart
#33
JOURNAL ARTICLE
Hao Zhang, Jiao Jiao, Tianheng Zhao, Enshuang Zhao, Lanhui Li, Guihua Li, Borui Zhang, Qing-Ming Qin
Rice blast, caused by Magnaporthe oryzae(M.oryzae), is a destructive rice disease that reduces rice yield by 10% to 30% annually. It also affects other cereal crops such as barley, wheat, rye, millet, sorghum, and maize. Small RNAs (sRNAs) play an essential regulatory role in fungus-plant interaction during the fungal invasion, but studies on pathogenic sRNAs during the fungal invasion of plants based on multi-omics data integration are rare. This paper proposes a novel approach called Graph Embedding combined with Random Walk with Restart (GERWR) to identify pathogenic sRNAs based on multi-omics data integration during M...
December 28, 2023: IEEE/ACM Transactions on Computational Biology and Bioinformatics
https://read.qxmd.com/read/38148162/exploring-potential-surrogate-systems-for-studying-the-early-steps-of-the-sporisorium-scitamineum-pathogenesis
#34
JOURNAL ARTICLE
Mariana Marrafon-Silva, Thiago Maia, Juliana Calderan-Rodrigues, Mariana Strabello, Lâina Oliveira, Silvana Creste, Maeli Melotto, Claudia Barros Monteiro-Vitorello
Despite its global importance as a primary source of table sugar and bioethanol, sugarcane faces a significant threat to its production due to diseases. One of these diseases, the sugarcane smut, involves the emergence of a whip-like structure from the host apical shoot. The slow onset of the disease is the most substantial challenge for researchers to investigate the molecular events leading to resistance or susceptibility. In this study, we explored the early interaction between the smut fungus Sporisorium scitamineum and foliar tissues of the model plants Arabidopsis thaliana and Nicotiana benthamiana ...
December 26, 2023: Phytopathology
https://read.qxmd.com/read/38131014/crosstalk-of-ferroptosis-and-oxidative-stress-in-infectious-diseases
#35
REVIEW
Yibao Hu, Bisha He, Qian Cao, Yue Li, Yun Tang, Ting Cao, Binfeng Peng, Xiangping Zhou, Shuangquan Liu
Ferroptosis is a type of programmed cell death that pathogens can leverage to enhance their replication, transmission, and pathogenicity. Hosts typically combat pathogenic infections by utilizing oxidative stress as a defense mechanism. Nonetheless, some pathogens can trigger considerable oxidative stress while infecting, inducing an intense inflammatory response in the host's immune system and activating cell death. The process of ferroptosis is closely linked to oxidative stress, with their interaction exerting a substantial impact on the outcome of infectious diseases...
2023: Frontiers in Molecular Biosciences
https://read.qxmd.com/read/38128715/antibiotic-resistance-genes-associated-with-size-segregated-bioaerosols-from-wastewater-treatment-plants-a-review
#36
REVIEW
Tang Yang, Xuyi Wang, Lu Jiang, Xin Sui, Xuejun Bi, Bo Jiang, Zhanpeng Zhang, Xinlong Li
The antibiotic-resistant pollution in size-segregated bioaerosols from wastewater treatment plants (WWTPs) is of increasing concern due to its public health risks, but an elaborate review is still lacking. This work overviewed the profile, mobility, pathogenic hosts, source, and risks of antibiotic resistance genes (ARGs) in size-segregated bioaerosols from WWTPs. The dominant ARG type in size-segregated bioaerosols from WWTPs was multidrug resistance genes. Treatment units that equipped with mechanical facilities and aeration devices, such as grilles, grit chambers, biochemical reaction tanks, and sludge treatment units, were the primary sources of bioaerosol antibiotic resistome in WWTPs...
December 19, 2023: Environmental Pollution
https://read.qxmd.com/read/38114080/possible-biological-control-of-ash-dieback-using-the-mycoparasite-hymenoscyphus-fraxineus-mitovirus-2
#37
JOURNAL ARTICLE
Wajeeha Shamsi, Jana Mittelstrass, Sven Ulrich, Hideki Kondo, Daniel Rigling, Simone Prospero
Invasive fungal diseases represent a major threat to forest ecosystems worldwide. As the application of fungicides is often unfeasible and not a sustainable solution, only a few other control options are available, including biological control. In this context, the use of parasitic mycoviruses as biocontrol agents of fungal pathogens has recently gained particular attention. Since the 1990s, the Asian fungus Hymenoscyphus fraxineus has been causing lethal ash dieback across Europe. In the present study, we investigated the biocontrol potential of the mitovirus Hymenoscyphus fraxineus mitovirus 2 (HfMV2) previously identified in Japanese populations of the pathogen...
December 19, 2023: Phytopathology
https://read.qxmd.com/read/38114076/genotypic-and-resistance-profile-analysis-of-two-oat-crown-rust-differential-sets-urge-coordination-and-standardisation
#38
JOURNAL ARTICLE
Duong T Nguyen, Eva Celeste Henningsen, Dave Lewis, Rohit Mago, Meredith McNeil, Radoslaw Suchecki, Scott Boden, Jana Sperschneider, Shahryar Kianian, Peter Dodds, Melania Figueroa
Puccinia coronata f. sp. avenae ( Pca ) is the causal agent of the disease known as crown rust which represents a bottleneck in oat production worldwide. Characterisation of pathogen populations often involves race (pathotype) assignments using differential sets, which are not uniform across countries. This study compared virulence profiles of 25 Pca isolates from Australia using two host differential sets, one from Australia and one from the USA. These differential sets were also genotyped using DArT sequencing technology...
December 19, 2023: Phytopathology
https://read.qxmd.com/read/38112465/tlr4-sensing-of-isdb-of-staphylococcus-aureus-induces-a-proinflammatory-cytokine-response-via-the-nlrp3-caspase-1-inflammasome-cascade
#39
JOURNAL ARTICLE
Juan José Izquierdo Gonzalez, Md Faruq Hossain, Jolanda Neef, Erin E Zwack, Chih-Ming Tsai, Dina Raafat, Kevin Fechtner, Luise Herzog, Thomas P Kohler, Rabea Schlüter, Alexander Reder, Silva Holtfreter, George Y Liu, Sven Hammerschmidt, Uwe Völker, Victor J Torres, Jan Maarten van Dijl, Christopher H Lillig, Barbara M Bröker, Murty N Darisipudi
The prevalence of multidrug-resistant Staphylococcus aureus is of global concern, and vaccines are urgently needed. The iron-regulated surface determinant protein B (IsdB) of S. aureus was investigated as a vaccine candidate because of its essential role in bacterial iron acquisition but failed in clinical trials despite strong immunogenicity. Here, we reveal an unexpected second function for IsdB in pathogen-host interaction: the bacterial fitness factor IsdB triggers a strong inflammatory response in innate immune cells via Toll-like receptor 4 and the inflammasome, thus acting as a novel pathogen-associated molecular pattern of S...
December 19, 2023: MBio
https://read.qxmd.com/read/38110413/dilution-of-specialist-pathogens-drives-productivity-benefits-from-diversity-in-plant-mixtures
#40
JOURNAL ARTICLE
Guangzhou Wang, Haley M Burrill, Laura Y Podzikowski, Maarten B Eppinga, Fusuo Zhang, Junling Zhang, Peggy A Schultz, James D Bever
Productivity benefits from diversity can arise when compatible pathogen hosts are buffered by unrelated neighbors, diluting pathogen impacts. However, the generality of pathogen dilution has been controversial and rarely tested within biodiversity manipulations. Here, we test whether soil pathogen dilution generates diversity- productivity relationships using a field biodiversity-manipulation experiment, greenhouse assays, and feedback modeling. We find that the accumulation of specialist pathogens in monocultures decreases host plant yields and that pathogen dilution predicts plant productivity gains derived from diversity...
December 18, 2023: Nature Communications
keyword
keyword
12554
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.