Juan José Izquierdo Gonzalez, Md Faruq Hossain, Jolanda Neef, Erin E Zwack, Chih-Ming Tsai, Dina Raafat, Kevin Fechtner, Luise Herzog, Thomas P Kohler, Rabea Schlüter, Alexander Reder, Silva Holtfreter, George Y Liu, Sven Hammerschmidt, Uwe Völker, Victor J Torres, Jan Maarten van Dijl, Christopher H Lillig, Barbara M Bröker, Murty N Darisipudi
The prevalence of multidrug-resistant Staphylococcus aureus is of global concern, and vaccines are urgently needed. The iron-regulated surface determinant protein B (IsdB) of S. aureus was investigated as a vaccine candidate because of its essential role in bacterial iron acquisition but failed in clinical trials despite strong immunogenicity. Here, we reveal an unexpected second function for IsdB in pathogen-host interaction: the bacterial fitness factor IsdB triggers a strong inflammatory response in innate immune cells via Toll-like receptor 4 and the inflammasome, thus acting as a novel pathogen-associated molecular pattern of S...
December 19, 2023: MBio