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https://www.readbyqxmd.com/read/29691859/survey-of-rabies-vaccination-status-of-queensland-veterinarians-and-veterinary-students
#1
D Mendez, L Foyle, R Cobbold, R Speare
BACKGROUND: To determine the rabies vaccination status of Queensland veterinarians and veterinary students and their perception of zoonotic risk from Australian bat lyssavirus (ABLV). DESIGN: Cross-sectional questionnaire surveys. METHODS: Questionnaires were sent by post in 2011 to veterinary surgeons registered in Queensland, to final-year veterinary students at James Cook University via SurveyMonkey® in 2013 and to final-year veterinary students at James Cook University and University of Queensland via SurveyMonkey® in 2014...
May 2018: Australian Veterinary Journal
https://www.readbyqxmd.com/read/29691788/tissue-identification-in-a-porcine-model-by-differential-ion-mobility-spectrometry-analysis-of-surgical-smoke
#2
Anton Kontunen, Markus Karjalainen, Jukka Lekkala, Antti Roine, Niku Oksala
Electrosurgery is widely used in various surgical operations. When tissue is cut with high-frequency current, the cell contents at the incision area evaporate and together with water and possible soot particles, form surgical smoke. The smoke contains cell metabolites, and therefore, possible biomarkers for cancer or bacterial infection. Thus, the analysis of surgical smoke could be used in intraoperative medical diagnostics. We present a method that can be used to detect the characteristics of various tissue types by means of differential ion mobility spectrometry (DMS) analysis of surgical smoke...
April 24, 2018: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/29691454/heterologous-dna-prime-protein-boost-immunization-with-reca-and-flid-offers-cross-clade-protection-against-leptospiral-infection
#3
Veerapandian Raja, Sankaran Sobana, Charles Solomon Akino Mercy, Bianca Cotto, Durlav Prasad Bora, Kalimuthusamy Natarajaseenivasan
The emergence of >300 serovars of Leptospira confounded the use of generalized bacterin, the whole cell lysate, as vaccines to control leptospirosis. Because of substantial genetic and geographic heterogeneity among circulating serovars, one vaccine strain per serovar cannot be efficacious against all the serovars. We have performed heterologous DNA prime-protein boost vaccination challenge studies in hamsters using in vivo expressed, leptospiral recombinase A (RecA) and flagellar hook associated protein (FliD)...
April 24, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29691387/fetal-demise-and-failed-antibody-therapy-during-zika-virus-infection-of-pregnant-macaques
#4
Diogo M Magnani, Thomas F Rogers, Nicholas J Maness, Nathan D Grubaugh, Nathan Beutler, Varian K Bailey, Lucas Gonzalez-Nieto, Martin J Gutman, Núria Pedreño-Lopez, Jaclyn M Kwal, Michael J Ricciardi, Tereance A Myers, Justin G Julander, Rudolf P Bohm, Margaret H Gilbert, Faith Schiro, Pyone P Aye, Robert V Blair, Mauricio A Martins, Kathrine P Falkenstein, Amitinder Kaur, Christine L Curry, Esper G Kallas, Ronald C Desrosiers, Pascal J Goldschmidt-Clermont, Stephen S Whitehead, Kristian G Andersen, Myrna C Bonaldo, Andrew A Lackner, Antonito T Panganiban, Dennis R Burton, David I Watkins
Zika virus (ZIKV) infection of pregnant women is associated with pathologic complications of fetal development. Here, we infect pregnant rhesus macaques (Macaca mulatta) with a minimally passaged ZIKV isolate from Rio de Janeiro, where a high rate of fetal development complications was observed. The infection of pregnant macaques with this virus results in maternal viremia, virus crossing into the amniotic fluid (AF), and in utero fetal deaths. We also treated three additional ZIKV-infected pregnant macaques with a cocktail of ZIKV-neutralizing human monoclonal antibodies (nmAbs) at peak viremia...
April 24, 2018: Nature Communications
https://www.readbyqxmd.com/read/29691339/outbreak-of-invasive-wound-mucormycosis-in-a-burn-unit-due-to-multiple-strains-of-mucor-circinelloides-f-circinelloides-resolved-by-whole-genome-sequencing
#5
Dea Garcia-Hermoso, Alexis Criscuolo, Soo Chan Lee, Matthieu Legrand, Marc Chaouat, Blandine Denis, Matthieu Lafaurie, Martine Rouveau, Charles Soler, Jean-Vivien Schaal, Maurice Mimoun, Alexandre Mebazaa, Joseph Heitman, Françoise Dromer, Sylvain Brisse, Stéphane Bretagne, Alexandre Alanio
Mucorales are ubiquitous environmental molds responsible for mucormycosis in diabetic, immunocompromised, and severely burned patients. Small outbreaks of invasive wound mucormycosis (IWM) have already been reported in burn units without extensive microbiological investigations. We faced an outbreak of IWM in our center and investigated the clinical isolates with whole-genome sequencing (WGS) analysis. We analyzed M. circinelloides isolates from patients in our burn unit (BU1, Hôpital Saint-Louis, Paris, France) together with nonoutbreak isolates from Burn Unit 2 (BU2, Paris area) and from France over a 2-year period (2013 to 2015)...
April 24, 2018: MBio
https://www.readbyqxmd.com/read/29691241/modern-contraceptive-use-among-hiv-infected-women-attending-hiv-care-centres-in-togo-a-cross-sectional-study
#6
Issifou Yaya, Akouda Akessiwè Patassi, Dadja Essoya Landoh, Essodjèlouna Manani Bignandi, Kanfitine Kolani, Abdel-Daim Daou Namoro, P'Niwè Massoubayo Patchali, Lihanimpo Djalogue, Didier Koumavi Ekouevi, Bayaki Saka
INTRODUCTION: Contraceptive use among HIV-infected women in Togo is poorly documented. We aim at assessing the prevalence of modern contraceptive use and associated factors among HIV-infected women in Togo. DESIGN: Cross-sectional study. SETTING: The study was conducted in five HIV care centres in the Centrale and Kara regions in Togo. PARTICIPANTS: We included 461 HIV-positive women aged between 15 and 49 years and who were sexually active...
April 24, 2018: BMJ Open
https://www.readbyqxmd.com/read/29691098/improved-patency-after-axillofemoral-bypass-for-aortoiliac-occlusive-disease
#7
Russell H Samson, David P Showalter, Michael R Lepore, Deepak G Nair, Douglas A Dorsay, Ricardo E Morales
OBJECTIVE: Axillofemoral bypasses (AxFBs) have been used since 1962 to treat aortoiliac disease. In the past, reported patency rates (37%-76%) for these extra-anatomic grafts have been inferior to those for anatomic aortic grafting. Reported low survival rates after AxFB (40%-50%) have confirmed that these procedures have been used primarily in patients at high risk for complications from aortofemoral bypass. However, modern medical and anesthesia management, preoperative scanning, donor artery preparation, postoperative graft surveillance, and graft technology may improve outcomes after AxFB, possibly supporting expansion of its use...
April 21, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29690971/clinical-spectrum-and-outcome-of-cerebral-venous-sinus-thrombosis-in-children
#8
Iram Javed, Tipu Sultan, Zia Ur Rehman, Muhammad Rizwan Yaseen
OBJECTIVE: To determine clinical spectrum, neuroimaging finding and outcome of cerebral venous sinus thrombosis (CVST) in children. STUDY DESIGN: Descriptive and cross-sectional study. PLACE AND DURATION OF STUDY: Department of Paediatric Neurology, Children's Hospital and Institute of Child Health, Lahore, from 2015 to 2016. METHODOLOGY: Data was collected in a predesigned proforma by non-probability purposive sampling technique from all enrolled 32 patients fulfilling the inclusion criteria...
May 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29690913/distribution-of-plasmodium-spp-infection-in-asymptomatic-carriers-in-perennial-and-low-seasonal-malaria-transmission-settings-in-west-africa
#9
Constant G N Gbalégba, Hampâté Ba, Kigbafori D Silué, Ousmane Ba, Emmanuel Tia, Mouhamadou Chouaibou, Nathan T Y Tian-Bi, Grégoire Y Yapi, Brama Koné, Jürg Utzinger, Benjamin G Koudou
BACKGROUND: Since 2000, substantial progress has been made in reducing malaria worldwide. However, some countries in West Africa remain a hotspot for malaria with all age groups at risk. Asymptomatic carriers of Plasmodium spp. are important sources of infections for malaria vectors and thus contribute to the anchoring of the disease in favourable eco-epidemiological settings. The objective of this study was to assess the asymptomatic malaria case rates in Korhogo and Kaedi, two urban areas in northern Côte d'Ivoire and southern Mauritania, respectively...
April 25, 2018: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/29689721/reaction-of-amyloid-%C3%AE-peptide-antibody-with-different-infectious-agents-involved-in-alzheimer-s-disease
#10
Aristo Vojdani, Elroy Vojdani, Evan Saidara, Datis Kharrazian
As early as the 1980s, molecular virologist Ruth Itzhaki began to investigate if there was a causal connection between infections and neurodegenerative disorder. Although the theory has yet to be universally embraced, in 2016 Itzhaki and 33 other scientists from all over the world published a review article in this very journal presenting evidence for the causal role of pathogens in Alzheimer's disease (AD). Exactly how and in what way pathogens affect the induction of AD has yet to be determined, but one possible answer may involve the cross-reactivity of different pathogens with amyloid-β (Aβ)...
April 14, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29688853/gender-difference-in-health-related-quality-of-life-and-associated-factors-among-people-living-with-hiv-aids-attending-anti-retroviral-therapy-at-public-health-facilities-western-ethiopia-comparative-cross-sectional-study
#11
Delelegn Yilma Gebremichael, Kokeb Tesfamariam Hadush, Ermiyas Mulu Kebede, Robel Tezera Zegeye
BACKGROUND: Though HIV/AIDS has multidimensional consequences on quality of life, there is a gap in measuring and monitoring health related quality of life of HIV/AIDS patients. Hence, this study intended to measure health related quality of life domains and associated determinants among people living with HIV/AIDS in western Ethiopia. METHODS: A comparative cross-sectional study was conducted among 520 HIV/AIDS patients on anti-retroviral therapy in public health facilities in West Shoa Zone, Western Ethiopia from April to May, 2016...
April 23, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29688811/trehalose-6-phosphate-phosphatases-of-pseudomonas-aeruginosa
#12
Megan Cross, Sonja Biberacher, Suk-Youl Park, Siji Rajan, Pasi Korhonen, Robin B Gasser, Jeong-Sun Kim, Mark J Coster, Andreas Hofmann
The opportunistic bacterium Pseudomonas aeruginosa has been recognized as an important pathogen of clinical relevance and is a leading cause of hospital-acquired infections. The presence of a glycolytic enzyme in Pseudomonas, which is known to be inhibited by trehalose 6-phosphate (T6P) in other organisms, suggests that these bacteria may be vulnerable to the detrimental effects of intracellular T6P accumulation. In the present study, we explored the structural and functional properties of trehalose 6-phosphate phosphatase (TPP) in P...
April 24, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29687691/side-effects-of-anabolic-steroids-used-by-athletes-at-unaizah-gyms-saudi-arabia-a-pilot-study
#13
Amer A Almaiman, Sulaiman H Almaiman, Elsayed I Elagamy, Osama Al Wutayd, Mohammed Almarzuqi, Rayyan Alzunaidi, Sami Alhatlani, Eltayeb E Eid
BACKGROUND: A large number of Saudi athletes are recently shown to use androgenic anabolic steroid (AAS) products to achieve rapid muscle growth without realizing the serious health risks of these drugs. Aim of this study was to elucidate the side effects encountered with prolonged use of AAS products by Saudi athletes. METHODS: A cross-sectional study was conducted, in which 16 regular gym members, 12 of them used AAS, were asked to answer a questionnaire and provide blood samples following current AAS course completion...
April 20, 2018: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/29687507/hiv-knowledge-and-use-of-health-services-among-people-from-south-east-asia-and-sub-saharan-africa-living-in-western-australia
#14
Corie Gray, Gemma Crawford, Alison Reid, Roanna Lobo
BACKGROUND: HIV notifications among people born in sub-Saharan Africa and South East Asia have increased in Australia in the last decade. People born in these regions have the highest rates of HIV diagnosis by region of birth and are overrepresented in late or advanced presentation of HIV infection. METHODS: This study developed and tested a questionnaire for reliability through test-retest. A cross-sectional survey using intercept and online recruitment of HIV knowledge and use of health services was then undertaken among people born in sub-Saharan Africa and South East Asia, who had arrived in Australia less than ten years ago and were living in Western Australia (n=209)...
April 23, 2018: Health Promotion Journal of Australia
https://www.readbyqxmd.com/read/29686984/a-mini-review-of-the-zoonotic-threat-potential-of-influenza-viruses-coronaviruses-adenoviruses-and-enteroviruses
#15
REVIEW
Emily S Bailey, Jane K Fieldhouse, Jessica Y Choi, Gregory C Gray
During the last two decades, scientists have grown increasingly aware that viruses are emerging from the human-animal interface. In particular, respiratory infections are problematic; in early 2003, World Health Organization issued a worldwide alert for a previously unrecognized illness that was subsequently found to be caused by a novel coronavirus [severe acute respiratory syndrome (SARS) virus]. In addition to SARS, other respiratory pathogens have also emerged recently, contributing to the high burden of respiratory tract infection-related morbidity and mortality...
2018: Frontiers in Public Health
https://www.readbyqxmd.com/read/29686960/shifting-the-paradigm-of-emergency-care-in-developing-countries
#16
Ayesha Khan, Bradley T Penoff, Elizabeth A Pirrotta, Robert Hosang
Background The global agenda does not address a significant amount of preventable death in low- and middle-income countries (LMICs). While illnesses requiring acute care are increasing at an alarming rate in these countries, there are inadequate numbers of physicians or nurses to deal with the growing burden. Many people feel that emergency systems are too expensive and restricted in scope to have public health implications in resource-limited areas. Little empirical data exists to suggest otherwise. The goal of this study was to delineate the type and frequency of emergency conditions and define a novel method to estimate the burden of emergency diseases in Fort Liberte, Haiti...
February 22, 2018: Curēus
https://www.readbyqxmd.com/read/29686657/naphthoquinone-derivatives-as-scaffold-to-develop-new-drugs-for-tuberculosis-treatment
#17
Priscila C B Halicki, Laís A Ferreira, Kelly C G De Moura, Paula F Carneiro, Karina P Del Rio, Tatiane Dos S C Carvalho, Maria do C F R Pinto, Pedro E A da Silva, Daniela F Ramos
Despite being a curable disease, tuberculosis (TB) remains a public health problem worldwide mainly due to lengthy treatment, as well as its toxic effects, TB/HIV co-infection and the emergence of resistant Mycobacterium tuberculosis strains. These barriers reinforcing the need for development of new antimicrobial agents, that ideally should reduce the time of treatment and be active against susceptible and resistant strains. Quinones are compounds found in natural sources and among them, the naphthoquinones show antifungal, antiparasitic, and antimycobacterial activity...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29686521/knowledge-attitude-and-practice-of-secondary-schools-and-university-students-toward-middle-east-respiratory-syndrome-epidemic-in-saudi-arabia-a-cross-sectional-study
#18
Ali Al-Hazmi, Ibrahim Gosadi, Ali Somily, Sarah Alsubaie, Abdulaziz Bin Saeed
This study was aiming to investigate the knowledge, practice and attitudes of secondary school and university students toward MERS-CoV infection. This is a cross-sectional study conducted in Riyadh, Saudi Arabia. Study participants were recruited from several constituent colleges of King Saud University and secondary schools in Riyadh. Data were collected using self-administered, closed-ended questionnaires. Frequencies and proportions were computed for descriptive purposes. Chi square test was utilized to depict statistical difference between groups...
March 2018: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/29685813/eradication-of-early-p-aeruginosa-infection-in-children-7-years-of-age-with-cystic-fibrosis-the-early-study
#19
Felix Ratjen, Alexander Moeller, Martha L McKinney, Irina Asherova, Nipa Alon, Robert Maykut, Gerhild Angyalosi
OBJECTIVE: Antibiotic eradication treatment is the standard-of-care for cystic fibrosis (CF) patients with early Pseudomonas aeruginosa (Pa)-infection; however, evidence from placebo-controlled trials is limited. METHODS: This double-blind, placebo-controlled trial randomised CF patients <7 years (N = 51) with early Pa-infection to tobramycin inhalation solution (TOBI 300 mg) or placebo (twice daily) for 28 days with an optional cross-over on Day 35...
April 20, 2018: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://www.readbyqxmd.com/read/29685693/effect-of-aspirin-treatment-on-abacavir-associated-platelet-hyperreactivity-in-hiv-infected-patients
#20
Emanuela Falcinelli, Daniela Francisci, Elisabetta Schiaroli, Pietro Minuz, Sara Orsini, Lisa Malincarne, Manuela Sebastiano, Anna Maria Mezzasoma, Maria Bruna Pasticci, Giuseppe Guglielmini, Franco Baldelli, Paolo Gresele
BACKGROUND: Ischemic cardiovascular events are a relevant cause of morbidity and mortality in HIV-infected patients. Use of abacavir (ABC), a nucleoside analog reverse transcriptase inhibitor, has been associated with increased risk of myocardial infarction (MI) and with platelet hyperreactivity. We explored whether low-dose aspirin reduces in vivo platelet activation and platelet hyperreactivity induced by ABC in HIV-infected subjects. METHODS AND RESULTS: In a randomized, placebo-controlled, cross-over study forty HIV-infected patients with ABC-associated platelet hyperreactivity, defined by a score based on laboratory variables reflecting in vivo platelet activation and ex vivo platelet hyperresponsiveness, were randomized to aspirin 100 mg daily for 15 days with subsequent cross-over to placebo for additional 15 days or placebo for 15 days with subsequent cross-over to aspirin for further 15 days...
April 12, 2018: International Journal of Cardiology
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