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https://www.readbyqxmd.com/read/28339786/modelling-original-antigenic-sin-in-dengue-viral-infection
#1
Ryan Nikin-Beers, Stanca M Ciupe
Cross-reactive T cell responses induced by a primary dengue virus infection may contribute to increased disease severity following heterologous infections with a different virus serotype in a phenomenon known as the original antigenic sin. In this study, we developed and analyzed in-host models of T cell responses to primary and secondary dengue virus infections that considered the effect of T cell cross-reactivity in disease enhancement. We fitted the models to published patient data and showed that the overall infected cell killing is similar in dengue heterologous infections, resulting in dengue fever and dengue hemorrhagic fever...
February 27, 2017: Mathematical Medicine and Biology: a Journal of the IMA
https://www.readbyqxmd.com/read/28339497/women-s-knowledge-and-perception-of-male-circumcision-before-and-after-its-roll-out-in-the-south-african-township-of-orange-farm-from-community-based-cross-sectional-surveys
#2
Barbara Maraux, Pascale Lissouba, Reathe Rain-Taljaard, Dirk Taljaard, Julie Bouscaillou, David Lewis, Adrian Puren, Bertran Auvert
The roll-out of medical male circumcision (MC) is progressing in Southern and Eastern Africa. Little is known about the effect of this roll-out on women. The objective of this study was to assess the knowledge and perceptions of women regarding MC in a setting before and after the roll-out. This study was conducted in the South African township of Orange Farm where MC prevalence among men increased from 17% to 53% in the period 2008-2010. Data from three community-based cross sectional surveys conducted in 2007, 2010 and 2012 among 1258, 1197 and 2583 adult women, respectively were studied...
2017: PloS One
https://www.readbyqxmd.com/read/28335535/enterovirus-71-neutralizing-antibodies-seroepidemiological-research-among-children-in-guangzhou-china-between-2014-and-2015-a-cross-sectional-study
#3
Dingmei Zhang, Yan Chen, Xiashi Chen, Zhenjian He, Xun Zhu, Yuantao Hao
A hand-foot-mouth disease outbreak occurred in 2014 around Guangdong. The purpose of this study was investigating the status and susceptibility of infectious neutralizing antibodies to enterovirus 71 among children so as to provide scientific evidence for the population immunity level of hand-foot-mouth disease and prepare for enterovirus 71 vaccination implementation. Serum specimens were collected from children in communities from January 2014 to March 2015 in Guangzhou. A total of 197 serum samples from children 1-5 years old were collected for this cross-sectional study via non-probabilistic sampling from the database of Chinese National Science and Technique Major Project...
March 20, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28335490/monitoring-of-selected-health-indicators-in-children-living-in-a-copper-mine-development-area-in-northwestern-zambia
#4
Astrid M Knoblauch, Mark J Divall, Milka Owuor, Colleen Archer, Kennedy Nduna, Harrison Ng'uni, Gertrude Musunka, Anna Pascall, Jürg Utzinger, Mirko S Winkler
The epidemiology of malaria, anaemia and malnutrition in children is potentially altered in mining development areas. In a copper extraction project in northwestern Zambia, a health impact assessment (HIA) was commissioned to predict, manage and monitor health impacts. Two cross-sectional surveys were conducted: at baseline prior to project development (2011) and at four years into development (2015). Prevalence of Plasmodium falciparum, anaemia and stunting were assessed in under-five-year-old children, while hookworm infection was assessed in children aged 9-14 years in communities impacted and comparison communities not impacted by the project...
March 19, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28335474/coccolithoviruses-a-review-of-cross-kingdom-genomic-thievery-and-metabolic-thuggery
#5
Jozef I Nissimov, António Pagarete, Fangrui Ma, Sean Cody, David D Dunigan, Susan A Kimmance, Michael J Allen
Coccolithoviruses (Phycodnaviridae) infect and lyse the most ubiquitous and successful coccolithophorid in modern oceans, Emiliania huxleyi. So far, the genomes of 13 of these giant lytic viruses (i.e., Emiliania huxleyi viruses-EhVs) have been sequenced, assembled, and annotated. Here, we performed an in-depth comparison of their genomes to try and contextualize the ecological and evolutionary traits of these viruses. The genomes of these EhVs have from 444 to 548 coding sequences (CDSs). Presence/absence analysis of CDSs identified putative genes with particular ecological significance, namely sialidase, phosphate permease, and sphingolipid biosynthesis...
March 18, 2017: Viruses
https://www.readbyqxmd.com/read/28335444/hiv-education-and-welfare-services-in-primary-care-an-empirical-model-of-integration-in-brazil-s-unified-health-system
#6
Rahbel Rahman, Rogério M Pinto, Melanie M Wall
Integration of health education and welfare services in primary care systems is a key strategy to solve the multiple determinants of chronic diseases, such as Human Immunodeficiency Virus Infection and Acquired Immune Deficiency Syndrome (HIV/AIDS). However, there is a scarcity of conceptual models from which to build integration strategies. We provide a model based on cross-sectional data from 168 Community Health Agents, 62 nurses, and 32 physicians in two municipalities in Brazil's Unified Health System (UHS)...
March 14, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28335421/pamam-dendrimers-cross-the-blood-brain-barrier-when-administered-through-the-carotid-artery-in-c57bl-6j-mice
#7
Bhairavi Srinageshwar, Sarah Peruzzaro, Melissa Andrews, Kayla Johnson, Allison Hietpas, Brittany Clark, Crystal McGuire, Eric Petersen, Jordyn Kippe, Andrew Stewart, Olivia Lossia, Abeer Al-Gharaibeh, Aaron Antcliff, Rebecca Culver, Douglas Swanson, Gary Dunbar, Ajit Sharma, Julien Rossignol
Drug delivery into the central nervous system (CNS) is challenging due to the blood-brain barrier (BBB) and drug delivery into the brain overcoming the BBB can be achieved using nanoparticles such as dendrimers. The conventional cationic dendrimers used are highly toxic. Therefore, the present study investigates the role of novel mixed surface dendrimers, which have potentially less toxicity and can cross the BBB when administered through the carotid artery in mice. In vitro experiments investigated the uptake of amine dendrimers (G1-NH₂ and G4-NH₂) and novel dendrimers (G1-90/10 and G4-90/10) by primary cortical cultures...
March 14, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28335280/pregnancy-vaccination-with-gold-glyco-nanoparticles-carrying-listeria-monocytogenes-peptides-protects-against-listeriosis-and-brain-and-cutaneous-associated-morbidities
#8
Ricardo Calderón-Gonzalez, Héctor Terán-Navarro, Elisabet Frande-Cabanes, Eva Ferrández-Fernández, Javier Freire, Soledad Penadés, Marco Marradi, Isabel García, Javier Gomez-Román, Sonsoles Yañez-Díaz, Carmen Álvarez-Domínguez
Listeriosis is a fatal infection for fetuses and newborns with two clinical main morbidities in the neonatal period, meningitis and diffused cutaneous lesions. In this study, we vaccinated pregnant females with two gold glyconanoparticles (GNP) loaded with two peptides, listeriolysin peptide 91-99 (LLO91-99) or glyceraldehyde-3-phosphate dehydrogenase 1-22 peptide (GAPDH1-22). Neonates born to vaccinated mothers were free of bacteria and healthy, while non-vaccinated mice presented clear brain affections and cutaneous diminishment of melanocytes...
August 19, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28334924/throat-swabs-in-children-with-respiratory-tract-infection-associations-with-clinical-presentation-and-potential-targets-for-point-of-care-testing
#9
Hannah V Thornton, Alastair D Hay, Niamh M Redmond, Sophie L Turnbull, Hannah Christensen, Tim J Peters, John P Leeming, Andrew Lovering, Barry Vipond, Peter Muir, Peter S Blair
Background and objectives.: Diagnostic uncertainty over respiratory tract infections (RTIs) in primary care contributes to over-prescribing of antibiotics and drives antibiotic resistance. If symptoms and signs predict respiratory tract microbiology, they could help clinicians target antibiotics to bacterial infection. This study aimed to determine relationships between symptoms and signs in children presenting to primary care and microbes from throat swabs. Methods.: Cross-sectional study of children ≥3 months to <16 years presenting with acute cough and RTI, with subset follow-up...
February 18, 2017: Family Practice
https://www.readbyqxmd.com/read/28334859/neurocognitive-function-of-school-aged-hiv-infected-children-in-enugu-nigeria
#10
Kenechukwu K Iloh, Ifeoma J Emodi, Ngozi S Ibeziako, Anthony N Ikefuna, Agozie C Ubesie, Ogochukwu N Iloh, Gideon C Ilechukwu, Adaeze C Ayuk
Background: Evidence has shown neurocognitive problems often exist among human immunodeficiency virus (HIV)-infected children. There are limited data for children in Nigeria. Methods: This was a cross-sectional study of 100 school-aged perinatally HIV-infected children seen in the paediatric HIV clinic and age/sex-matched controls from the general paediatric clinic. Neuro-cognitive functioning was assessed using the Raven's progressive matrices (RPM) that has been adapted for the Nigerian population...
February 20, 2017: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/28334789/comparative-evaluation-of-norovirus-infection-in-children-with-acute-gastroenteritis-by-rapid-immunochromatographic-test-rt-pcr-and-real-time-rt-pcr
#11
Kattareeya Kumthip, Pattara Khamrin, Wilaiporn Saikruang, Kanittapon Supadej, Hiroshi Ushijima, Niwat Maneekarn
Immunochromatographic (IC) test for norovirus detection is a rapid and simple detection method. This study evaluated the sensitivity and specificity of a recent version of R-Biopharm RIDA®QUICK Norovirus IC assay for norovirus detection in fecal specimens from children hospitalized with acute gastroenteritis. Fecal specimens were tested by IC kit in comparison with gold standard reverse transcription polymerase chain reaction (RT-PCR) and real-time RT-PCR. The IC kit showed high sensitivity and specificity comparable with PCR-based methods...
March 2, 2017: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/28334777/clinicians-interpretations-of-point-of-care-urine-culture-versus-laboratory-culture-results-analysis-from-the-four-country-poetic-trial-of-diagnosis-of-uncomplicated-urinary-tract-infection-in-primary-care
#12
Saskia Hullegie, Mandy Wootton, Theo J M Verheij, Emma Thomas-Jones, Janine Bates, Kerenza Hood, Micaela Gal, Nick A Francis, Paul Little, Michael Moore, Carl Llor, Timothy Pickles, David Gillespie, Nigel Kirby, Curt Brugman, Christopher C Butler
Background.: Urine culture at the point of care minimises delay between obtaining the sample and agar inoculation in a microbiology laboratory, and quantification and sensitivity results can be available more rapidly in primary care. Objective.: To identify the degree to which clinicians' interpretations of a point-of-care-test (POCT) urine culture (Flexicult™ SSI-Urinary Kit) agrees with laboratory culture in women presenting to primary care with symptoms of uncomplicated urinary tract infections (UTI)...
March 1, 2017: Family Practice
https://www.readbyqxmd.com/read/28333963/why-don-t-urban-youth-in-zambia-use-condoms-the-influence-of-gender-and-marriage-on-non-use-of-male-condoms-among-young-adults
#13
Jessie Pinchoff, Christopher B Boyer, Namuunda Mutombo, Rachna Nag Chowdhuri, Thoai D Ngo
BACKGROUND: Zambia experiences high unmet need for family planning and high rates of HIV, particularly among youth. While male condoms are widely available and 95% of adults have heard of them, self-reported use in the past 12 months is low among young adults (45%). This study describes factors associated with non-use of male condoms among urban young adults in Zambia. METHODS: A household cross-sectional survey in four urban districts was conducted from November 2015 to January 2016 among sexually active young adults ages 18-24 years...
2017: PloS One
https://www.readbyqxmd.com/read/28333938/the-relationship-between-entomological-indicators-of-aedes-aegypti-abundance-and-dengue-virus-infection
#14
Elizabeth A Cromwell, Steven T Stoddard, Christopher M Barker, Annelies Van Rie, William B Messer, Steven R Meshnick, Amy C Morrison, Thomas W Scott
Routine entomological monitoring data are used to quantify the abundance of Ae. aegypti. The public health utility of these indicators is based on the assumption that greater mosquito abundance increases the risk of human DENV transmission, and therefore reducing exposure to the vector decreases incidence of infection. Entomological survey data from two longitudinal cohort studies in Iquitos, Peru, linked with 8,153 paired serological samples taken approximately six months apart were analyzed. Indicators of Ae...
March 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28333923/interdisciplinary-approach-at-the-primary-healthcare-level-for-bolivian-immigrants-with-chagas-disease-in-the-city-of-s%C3%A3-o-paulo
#15
Maria Aparecida Shikanai Yasuda, Camila Gonçalves Sátolo, Noemia Barbosa Carvalho, Magda Maya Atala, Rosario Quiroga Ferrufino, Ruth Moreira Leite, Célia Regina Furucho, Expedito Luna, Rubens Antonio Silva, Marcia Hage, Caroline Medeji Ramos de Oliveira, Felipe Delatorre Busser, Vera Lucia Teixeira de Freitas, Dalva Marli Valerio Wanderley, Luzia Martinelli, Sonia Regina Almeida, Pedro Albajar Viñas, Nivaldo Carneiro
BACKGROUND/METHODS: In a pioneering cross-sectional study among Bolivian immigrants in the city of São Paulo, Brazil, the epidemiological profile, clinical manifestations and morbidity of Chagas disease were described. The feasibility of the management of Chagas disease at primary healthcare clinics using a biomedical and psychosocial interdisciplinary approach was also tested. Previously, a Trypanosoma cruzi (T. cruzi) infection rate of 4.4% among 633 immigrants was reported. The samples were screened using two commercial enzyme-linked immunoassay (ELISA) tests generated with epimastigote antigens, and those with discrepant or seropositive results were analyzed by confirmatory tests: indirect immunofluorescence (IFI), TESA-blot and a commercial recombinant ELISA...
March 23, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28333766/dietary-inadequacies-in-hiv-infected-and-uninfected-school-aged-children-in-johannesburg-south-africa
#16
Stephanie Shiau, Acadia Webber, Renate Strehlau, Faeezah Patel, Ashraf Coovadia, Samantha Kozakowski, Susan Brodlie, Michael T Yin, Louise Kuhn, Stephen M Arpadi
OBJECTIVES: The World Health Organization (WHO) recommends that HIV-infected children increase energy intake and maintain a balanced macronutrient distribution for optimal growth and nutrition. Few studies have evaluated dietary intake of HIV-infected children in resource-limited settings. METHODS: We conducted a cross-sectional analysis of the dietary intake of 220 perinatally HIV-infected children and 220 HIV-uninfected controls ages 5-9 years in Johannesburg, South Africa...
March 22, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28332721/rapid-detection-and-quantification-of-ebola-zaire-virus-by-one-step-real-time-quantitative-reverse-transcription-polymerase-chain-reaction
#17
Young-Tae Ro, Anysha Ticer, Ricardo Carrion, Jean L Patterson
Since Ebola virus causes a severe hemorrhagic fever in humans with mortality rates as high as 90%, the rapid and accurate detection of the virus is essential both for controlling the infection and for preventing further transmission. Here, we introduce one-step real-time quantitative reverse transcription-polymerase chain reaction (qRT-PCR) assays for the rapid and quantitative detection of an Ebola Zaire strain using GP, VP24 or VP40 gene as a target. Routine assay conditions for hydrolysis probe detection were established by the manufacturer's protocol used in the assays...
March 23, 2017: Microbiology and Immunology
https://www.readbyqxmd.com/read/28332651/serosurveillance-and-factors-associated-with-the-presence-of-antibodies-against-bluetongue-virus-in-dairy-cattle-in-two-eco-zones-of-nepal
#18
T N Gaire, S Karki, I P Dhakal, D R Khanal, R A Bowen
Cattle play an important role in the epidemiology of bluetongue (BT) by acting as reservoir hosts. However, the status of BT virus (BTV) in dairy cattle in Nepal is unknown. The objective of this study was to estimate the prevalence of BTV antibodies in dairy cattle in two eco-zones of Nepal, and to identify the factors associated with virus exposure. The authors conducted a cross-sectional serosurvey from March 2012 through February 2013 by sampling 131 dairy cattle from seven clusters (villages) in the Chitwan district in the Terai region (southern lowlands) and the Lamjung district in the Hills region (the middle part of Nepal)...
December 2016: Revue Scientifique et Technique
https://www.readbyqxmd.com/read/28332627/cross-neutralizing-anti-hiv-1-human-single-chain-variable-fragments-scfvs-against-cd4-binding-site-and-n332-glycan-identified-from-a-recombinant-phage-library
#19
Lubina Khan, Rajesh Kumar, Ramachandran Thiruvengadam, Hilal Ahmad Parray, Muzamil Ashraf Makhdoomi, Sanjeev Kumar, Heena Aggarwal, Madhav Mohata, Abdul Wahid Hussain, Raksha Das, Raghavan Varadarajan, Jayanta Bhattacharya, Madhu Vajpayee, K G Murugavel, Suniti Solomon, Subrata Sinha, Kalpana Luthra
More than 50% of HIV-1 infection globally is caused by subtype_C viruses. Majority of the broadly neutralizing antibodies (bnAbs) targeting HIV-1 have been isolated from non-subtype_C infected donors. Mapping the epitope specificities of bnAbs provides useful information for vaccine design. Recombinant antibody technology enables generation of a large repertoire of monoclonals with diverse specificities. We constructed a phage recombinant single chain variable fragment (scFv) library with a diversity of 7.8 × 10(8) clones, using a novel strategy of pooling peripheral blood mononuclear cells (PBMCs) of six select HIV-1 chronically infected Indian donors whose plasma antibodies exhibited potent cross neutralization efficiency...
March 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28332416/predicting-deoxynivalenol-in-oats-under-conditions-representing-scandinavian-production-regions
#20
Tomas Persson, Henrik Eckersten, Oleif Elen, Anne-Grete Roer Hjelkrem, Joel Markgren, Mats Söderström, Thomas Börjesson
Deoxynivalenol (DON) in cereals, produced by Fusarium fungi, cause poisoning in humans and animals. Fusarium infections in cereals are favoured by humid conditions. Host species are susceptible mainly during the anthesis stage. Infections are also positively correlated with a regional history of Fusarium infections, frequent cereal production and non-tillage field management practices. Here, previously developed process-based models based on relative air humidity, rain and temperature conditions, Fusarium sporulation, host phenology and mycelium growth in host tissue were adapted and tested on oats...
March 23, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
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