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https://www.readbyqxmd.com/read/28549400/bemfola-%C3%A2-fixed-dose-pens-potentially-reduce-drug-wastage-and-associated-costs-of-infertility-treatment
#1
Graham Foxon, Paul Mitchell, Nikki Turner, Anne McConnell, Helen Kendrew, Julian Jenkins
Bemfola(®) is a recombinant follicle-stimulating hormone (FSH) used during infertility treatment. One main differentiator between FSH products is their delivery device; consisting of multi-dose pens (Gonal-f(®)), vials or multi-dose preparations (Menopur(®)), or adjustable daily disposable dose pens (Bemfola(®)). To determine the potential impact of delivery device on drug wastage during infertility treatment this study retrospectively analysed Gonal-f(®) and Menopur(®) prescription and usage data from five UK clinics...
May 26, 2017: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/28549340/a-critical-assessment-of-the-in-vitro-measurement-of-cortical-bone-stiffness-with-ultrasound
#2
L Peralta, X Cai, P Laugier, Q Grimal
Elasticity assessment based on bulk wave velocity (BWV) measurements is the most popular technique to characterize the anisotropic stiffness tensor in cortical bone. Typically, a cuboid bone specimen is cut with its sides along the different anatomical directions. Then, the velocity of shear and longitudinal waves propagating along different directions are assessed, from which stiffness coefficients are calculated. Despite the importance of obtaining accurate elasticity values for bone research, there is no generally accepted protocol to measure BWV and the precision of the technique has been seldom investigated...
May 19, 2017: Ultrasonics
https://www.readbyqxmd.com/read/28543000/fine-needle-aspiration-with-selective-use-of-core-needle-biopsy-of-major-salivary-gland-tumors
#3
Erica B Romano, Jason M Wagner, Anthony M Alleman, Lichao Zhao, Rachel D Conrad, Greg A Krempl
OBJECTIVES: Preferential use of fine-needle aspiration (FNA) versus core needle biopsy (CNB) for distinguishing benign from malignant major salivary gland tumors is highly debated. The main disadvantage of FNA is lower sensitivity, whereas arguments against CNB include use of a larger bore needle and greater risk of complications. The aim of this study is to evaluate our experience performing ultrasound-guided (UG) FNA with selective use of CNB based on preliminary cytopathology, and to determine whether our preoperative diagnostic approach is more sensitive and specific than FNA alone-and at least as sensitive and specific as CNB alone...
May 23, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28539354/cerebral-oxygenation-and-regional-cerebral-perfusion-responses-with-resistance-breathing-during-central-hypovolemia
#4
Victoria L Kay, Justin Daniel Sprick, Caroline A Rickards
Resistance breathing improves tolerance to central hypovolemia induced by lower body negative pressure (LBNP), but this is not related to protection of anterior cerebral blood flow (indexed by mean middle cerebral artery velocity, MCAv). We hypothesized that inspiratory resistance breathing improves tolerance to central hypovolemia by maintaining cerebral oxygenation (ScO2), and protecting cerebral blood flow in the posterior cerebral circulation (indexed by posterior cerebral artery velocity, PCAv). Eight subjects (4M/4F) completed two experimental sessions of a presyncopal-limited LBNP protocol (3 mmHg/min onset rate) with and without (Control) resistance breathing via an impedance threshold device (ITD)...
May 24, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28537495/remotely-guided-breast-sonography-for-long-term-space-missions-a-case-report-and-discussion
#5
Jackelynne P Silva-Martinez, Andreia Sorice Genaro, Hui Annie Wen, Naama Glauber, Thais Russomano
BACKGROUND: Space radiation can cause different types of cancers in crewmembers, especially during long-term space missions. INTRODUCTION: To date, a complete bilateral breast ultrasound has not been performed at the International Space Station (ISS). A breast screening imaging technique could be a useful tool for early identification of breast cancer in astronauts. We hypothesized that breast ultrasound performed by a crewmember while being remotely guided by a specialist from the ground could be an essential tool for medical diagnosis in space...
May 24, 2017: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/28536754/movement-amplitude-on-the-functional-re-adaptive-exercise-device-deep-spinal-muscle-activity-and-movement-control
#6
A Winnard, D Debuse, M Wilkinson, L Samson, T Weber, Nick Caplan
PURPOSE: Lumbar multifidus (LM) and transversus abdominis (TrA) show altered motor control, and LM is atrophied, in people with low-back pain (LBP). The Functional Re-adaptive Exercise Device (FRED) involves cyclical lower-limb movement against minimal resistance in an upright posture. It has been shown to recruit LM and TrA automatically, and may have potential as an intervention for non-specific LBP. However, no studies have yet investigated the effects of changes in FRED movement amplitude on the activity of these muscles...
May 23, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28535235/effect-of-cephalexin-plus-trimethoprim-sulfamethoxazole-vs-cephalexin-alone-on-clinical-cure-of-uncomplicated-cellulitis-a-randomized-clinical-trial
#7
Gregory J Moran, Anusha Krishnadasan, William R Mower, Fredrick M Abrahamian, Frank LoVecchio, Mark T Steele, Richard E Rothman, David J Karras, Rebecca Hoagland, Stephanie Pettibone, David A Talan
Importance: Emergency department visits for skin infections in the United States have increased with the emergence of methicillin-resistant Staphylococcus aureus (MRSA). For cellulitis without purulent drainage, β-hemolytic streptococci are presumed to be the predominant pathogens. It is unknown if antimicrobial regimens possessing in vitro MRSA activity provide improved outcomes compared with treatments lacking MRSA activity. Objective: To determine whether cephalexin plus trimethoprim-sulfamethoxazole yields a higher clinical cure rate of uncomplicated cellulitis than cephalexin alone...
May 23, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28533624/relative-and-absolute-reliability-of-ultrasound-measurements-for-the-thickness-of-the-soft-tissue-around-the-shoulder-joint-of-young-normal-subjects
#8
Nobuhisa Ohya, Takumi Yamada, Yoshinao Satoh, Hirobumi Kawamura
[Purpose] The purpose of this study was to examine the reliability of ultrasound measurements by analyzing the relative reliability and absolute reliability when measuring soft tissue thickness around the shoulder joint. [Subjects and Methods] Eleven healthy young adults (22 shoulders) participated in this study. Thickness of the supraspinatus tendon, subacromial bursa, and biceps tendon was measured on both shoulders. This protocol was performed twice in the same day. The relative reliability of ultrasound measurement was evaluated using the intraclass correlation coefficient for determining the degree of consistency and agreement between two measures...
April 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28532824/puppy-survival-and-vigor-associated-with-the-use-of-low-dose-medetomidine-premedication-propofol-induction-and-maintenance-of-anesthesia-using-sevoflurane-gas-inhalation-for-cesarean-section-in-the-bitch
#9
K G M De Cramer, K E Joubert, J O Nöthling
The safety of an anesthetic protocol consisting of medetomidine hydrochloride (7 μg/kg iv) as premedicant, propofol, (1-2 mg/kg iv) as induction agent and sevoflurane, at 2% in oxygen for maintenance of anesthesia was studied in 292 cesarean sections (CSs) and 2232 puppies delivered. Medetomidine effects were reversed using atipamezole hydrochloride at 50 μg/puppy sc immediately following delivery and in the bitch iv immediately following surgery. The protocol's safety for puppies was expressed using survival immediately, 2 h and 7 d after delivery, and Apgar scores (measurement starting 15 min after delivery of the last puppy)...
July 1, 2017: Theriogenology
https://www.readbyqxmd.com/read/28532478/study-protocol-a-double-blind-randomised-control-trial-of-high-volume-image-guided-injections-in-achilles-and-patellar-tendinopathy-in-a-young-active-population
#10
Robert M Barker-Davies, Alastair Nicol, I McCurdie, James Watson, Polly Baker, Patrick Wheeler, Daniel Fong, Mark Lewis, Alexander N Bennett
BACKGROUND: Chronic tendinopathy is a significant problem particularly in active populations limiting sporting and occupational performance. The prevalence of patellar tendinopathy in some sports is near 50% and the incidence of lower limb tendinopathy is 1.4% p.a. in the UK Military. Management includes isometric, eccentric, heavy slow resistance exercises and extracorporeal shockwave therapy (ESWT). Often these treatments are inadequate yet there is no good evidence for injection therapies and success rates from surgery can be as low as 50%...
May 22, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28532243/transabdominal-ultrasonography-defined-optimal-and-definitive-bladder-filling-protocol-with-time-trends-during-pelvic-radiation-for-cervical-cancer
#11
Mahantshetty Umesh, Deepak P Kumar, Pranav Chadha, Rajiv Choudary, Seema Kembhavi, Meenakshi Thakur, Engineer Reena, Supriya Chopra, Shyamkishore Shrivastava
PURPOSE: Advanced radiotherapy techniques have emphasized on the importance of accurate target volume localization and delineation. The aim of this study was to determine time taken to achieve moderate bladder volume under physiological conditions, using transabdominal ultrasound. MATERIALS AND METHODS: Patients with cervical cancer undergoing radical radiation with or without concomitant chemotherapy underwent serial ultrasound to estimate bladder filling. With a strict bladder protocol of consuming 1000 mL of water orally over 30 minutes after emptying the bladder, ultrasound was done after 45 minutes from bladder emptying time and repeated at 15-minute interval till 300 (25) mL filling was achieved and repeated every week...
January 1, 2017: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/28522757/functional-assessment-of-the-diaphragm-by-speckle-tracking-ultrasound-during-inspiratory-loading
#12
Eline Oppersma, Nima Hatam, Jonne Doorduin, Johannes G van der Hoeven, Gernot Marx, Andreas Goetzenich, Sebastian Fritsch, Leo M A Heunks, Christian S Bruells
BACKGROUND: Assessment of diaphragmatic effort is challenging especially in critically ill patients in the phase of weaning. Fractional thickening during inspiration assessed by ultrasound has been used to estimate diaphragm effort. It is unknown whether more sophisticated ultrasound techniques such as speckle tracking are superior in the quantification of inspiratory effort. This study evaluates the validity of speckle tracking ultrasound to quantify diaphragm contractility. METHODS: Thirteen healthy volunteers underwent a randomized stepwise threshold loading protocol of 0 to 50% of the maximal inspiratory pressure...
May 18, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28521786/role-of-routine-abdominal-ultrasonography-in-intensified-tuberculosis-case-finding-algorithms-at-hiv-clinics-in-high-tb-burden-settings
#13
Sonam Spalgais, Upasna Agarwal, Rohit Sarin, Devesh Chauhan, Anita Yadav, Anand Jaiswal
BACKGROUND: High proportion of TB in people living with HIV (PLHIV) is undiagnosed. Due to this active TB case finding is recommended for HIV clinics in high TB burden countries. Presently sputum examination and chest radiography are frontline tests recommended for HIV infected TB presumptives. Abdominal TB which occurs frequently in PLHIV may be missed even by existing programmatic intensified case finding protocols. This study evaluated the routine use of ultrasonography (USG) for active case finding of abdominal TB in HIV clinics...
May 18, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28517999/venous-gas-emboli-and-ambulation-at-4-3-psia
#14
Johnny Conkin, Neal W Pollock, Michael J Natoli, Stefanie D Martina, James H Wessel, Michael L Gernhardt
INTRODUCTION: Ambulation during extravehicular activity on Mars may increase the risk of decompression sickness through enhanced bubble formation in the lower body. HYPOTHESES: walking effort (ambulation) before an exercise-enhanced denitrogenation (prebreathe) protocol at 14.7 psia does not increase the incidence of venous gas emboli (VGE) at 4.3 psia, but does increase incidence if performed after tissues become supersaturated with nitrogen at 4.3 psia. METHODS: VGE results from 45 control subjects who performed exercise prebreathe without ambulation before or during a 4-h exposure to 4...
April 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28515954/a-prospective-cohort-study-of-thoracic-ultrasound-in-acute-respiratory-failure-the-c3po-protocol
#15
Peter D Wallbridge, Simon A Joosten, Liam M Hannan, Daniel P Steinfort, L Irving, J Goldin, Mark Hew
OBJECTIVES: This study was performed to assess the clinical utility of a standardised thoracic ultrasound examination when added to standard care in patients with acute respiratory failure admitted to an intermediate care unit. This study aimed to assess the impact on clinical diagnosis, clinician confidence and management. Ultrasound has been shown to have utility in patients admitted to intensive care and emergency; however, utility in a ward setting is unknown. DESIGN: Prospective cohort study...
May 2017: JRSM Open
https://www.readbyqxmd.com/read/28514289/anti-angiogenic-therapy-with-contrast-enhanced-ultrasound-in-colorectal-cancer-patients-with-liver-metastasis
#16
Zhiyong Wu, Xiaowei Yang, Li Chen, Zhikuan Wang, Yan Shi, Hui Mao, Guanghai Dai, Xiaoling Yu
The aim of the study was to evaluate the efficacy of anti-angiogenic therapy with dynamic contrast-enhanced ultrasound (DCE-US) in colorectal cancer (CRC) patients with liver metastasis.A total of 50 CRC patients with liver metastasis who received bevacizumab (BEV)-based chemotherapy (BEV + FOLFOX6 protocol) were recruited into the present study. Before the study (d0), and 3, 7, 14, and 42 days (d3, d7, d14, and d42) after chemotherapy, DCE-US was performed, and tumor perfusion was evaluated quantitatively by retention time (RT), peak enhancement (PE), and wash-in area under the curve (WiAUC) on the basis of a contrast-uptake curve determined with original linear data...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28509763/achilles-tendon-load-is-progressively-increased-with-reductions-in-walking-speed
#17
Torsten Brauner, Philippe Pourcelot, Nathalie Crevier-Denoix, Thomas Horstmann, Scott C Wearing
INTRODUCTION: Achilles tendon rehabilitation protocols commonly recommend a gradual increase in walking speed to progressively intensify tendon loading. This study used transmission-mode ultrasound to evaluate the influence of walking speed on loading of the human Achilles tendon in vivo. METHODS: Axial transmission speed of ultrasound was measured in the right Achilles tendon of 33 adults (mean ± SD; age, 29 ± 3 years; height, 1.725 ± 0.069 m; weight, 71.4 ± 19...
May 15, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28504278/high-frequency-linear-rheology-of-hydrogels-probed-by-ultrasound-driven-microbubble-dynamics
#18
Akaki Jamburidze, Marco De Corato, Axel Huerre, Angelo Pommella, Valeria Garbin
Ultrasound-driven microbubble dynamics are central to biomedical applications, from diagnostic imaging to drug delivery and therapy. In therapeutic applications, the bubbles are typically embedded in tissue, and their dynamics are strongly affected by the viscoelastic properties of the soft solid medium. While the behaviour of bubbles in Newtonian fluids is well characterised, a fundamental understanding of the effect on ultrasound-driven bubble dynamics of a soft viscoelastic medium is still being developed...
May 15, 2017: Soft Matter
https://www.readbyqxmd.com/read/28503204/ultrasound-promoted-organocatalytic-enamine-azide-3-2-cycloaddition-reactions-for-the-synthesis-of-arylselanyl-phenyl-1h-1-2-3-triazol-4-yl-ketones
#19
Gabriel P Costa, Natália Seus, Juliano A Roehrs, Raquel G Jacob, Ricardo F Schumacher, Thiago Barcellos, Rafael Luque, Diego Alves
The use of sonochemistry is described in the organocatalytic enamine-azide [3 + 2] cycloaddition between 1,3-diketones and aryl azidophenyl selenides. These sonochemically promoted reactions were found to be amenable to a range of 1,3-diketones or aryl azidophenyl selenides, providing an efficient access to new ((arylselanyl)phenyl-1H-1,2,3-triazol-4-yl)ketones in good to excellent yields and short reaction times. In addition, this protocol was extended to β-keto esters, β-keto amides and α-cyano ketones...
2017: Beilstein Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28501967/plaque-tissue-morphology-based-stroke-risk-stratification-using-carotid-ultrasound-a-polling-based-pca-learning-paradigm
#20
Luca Saba, Pankaj K Jain, Harman S Suri, Nobutaka Ikeda, Tadashi Araki, Bikesh K Singh, Andrew Nicolaides, Shoaib Shafique, Ajay Gupta, John R Laird, Jasjit S Suri
Severe atherosclerosis disease in carotid arteries causes stenosis which in turn leads to stroke. Machine learning systems have been previously developed for plaque wall risk assessment using morphology-based characterization. The fundamental assumption in such systems is the extraction of the grayscale features of the plaque region. Even though these systems have the ability to perform risk stratification, they lack the ability to achieve higher performance due their inability to select and retain dominant features...
June 2017: Journal of Medical Systems
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