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https://www.readbyqxmd.com/read/29334270/secukinumab-in-multi-failure-psoriatic-patients-the-last-hope
#1
M Magnano, C Loi, A Patrizi, P Sgubbi, R Balestri, G Rech, L Tasin, C R Girardelli, A Conti, G Odorici, A Campanati, A M Offidani, F Bardazzi
Psoriasis is a multi-systemic chronic inflammatory disease that affects about 1.5-3% of the general population, of which almost 20% suffer from a moderate-severe form. Those patients can be treated with a systemic agent, and, in case of scarce response or contraindications, they may require a biologic therapy, such as tumor necrosis factor or interleukin-12/23 inhibitors. When also those agents fail, clinicians face a true therapeutic challenge. We report a case series of multi-failure 16 patients, successfully treated with secukinumab, a fully human monoclonal antibody that selectively neutralizes interleukin-17A, recently approved for the treatment of plaque psoriasis, psoriatic arthritis and ankylosing spondylitis...
January 15, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29333268/progress-of-genome-wide-association-studies-of-ankylosing-spondylitis
#2
REVIEW
Zhixiu Li, Matthew A Brown
Ankylosing spondylitis (AS) is an immune-mediated arthritis which primarily affects the spine and sacroiliac joints. Significant progress has been made in discovery of genetic associations with AS by genome-wide association studies (GWAS) over past decade. These findings have uncovered novel pathways involved pathogenesis of the disease and have led to introduction of novel therapeutic treatments for AS. In this Review, we discuss the genetic variations associated with AS identified by GWAS, the major pathways revealed by these AS-associated variations and critical cell types involved in AS development...
December 2017: Clinical & Translational Immunology
https://www.readbyqxmd.com/read/29332746/is-pilates-an-effective-rehabilitation-tool-a-systematic-review
#3
REVIEW
Keira Byrnes, Ping-Jung Wu, Stephney Whillier
BACKGROUND: Pilates is a system of exercise focusing upon controlled movement, stretching and breathing. Pilates is popular today not only for physical fitness but also for rehabilitation programs. This paper is a review of the literature on the effectiveness of Pilates as a rehabilitation tool in a wide range of conditions in an adult population. METHODS: A systematic literature review was carried out according to the PRISMA guidelines. Electronic databases were searched for cohort studies or randomised controlled trials (RCTs), and inclusion and exclusion criteria were applied...
January 2018: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/29329443/bone-formation-in-ankylosing-spondylitis-during-anti-tumour-necrosis-factor-therapy-imaged-by-18f-fluoride-positron-emission-tomography
#4
Stefan T G Bruijnen, Nicki J F Verweij, Leonie M van Duivenvoorden, Nathalie Bravenboer, Dominique L P Baeten, Christiaan J van Denderen, Irene E van der Horst-Bruinsma, Alexandre E Voskuyl, Martijn Custers, Peter M van de Ven, Joost C J Bot, Bouke J H Boden, Adriaan A Lammertsma, Otto S H Hoekstra, Pieter G H M Raijmakers, Conny J van der Laken
Objectives: Excessive bone formation is an important hallmark of AS. Recently it has been demonstrated that axial bony lesions in AS patients can be visualized using 18F-fluoride PET-CT. The aim of this study was to assess whether 18F-fluoride uptake in clinically active AS patients is related to focal bone formation in spine biopsies and is sensitive to change during anti-TNF treatment. Methods: Twelve anti-TNF-naïve AS patients [female 7/12; age 39 years (SD 11); BASDAI 5...
January 9, 2018: Rheumatology
https://www.readbyqxmd.com/read/29329380/circulating-micrornas-as-potential-biomarkers-of-disease-activity-and-structural-damage-in-ankylosing-spondylitis-patients
#5
Carlos Perez-Sanchez, Pilar Font-Ugalde, Patricia Ruiz-Limon, Chary Lopez-Pedrera, Maria C Castro-Villegas, Maria C Abalos-Aguilera, Nuria Barbarroja, Ivan Arias-de la Rosa, Maria D Lopez-Montilla, Alejandro Escudero-Contreras, Clementina Lopez-Medina, Eduardo Collantes-Estevez, Yolanda Jimenez-Gomez
Ankylosing spondylitis (AS) remains difficult to diagnose before irreversible damage to sacroiliac joint is noticeable. Circulating microRNAs have demonstrated to serve as diagnostic tools for several human diseases. Here, we analyzed plasma microRNAs to identify potential AS biomarkers. Higher expression levels of microRNA (miR)-146a-5p, miR-125a-5p, miR-151-3p, and miR-22-3p, and lower of miR-150-5p, and miR-451a were found in AS versus healthy donors. Interestingly, higher miR-146a-5p, miR-125a-5p, miR-151-3p, miR-22-3p, and miR-451a expression was also observed in AS than psoriatic arthritis patients...
January 10, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29328507/genetics-of-immune-mediated-inflammatory-diseases
#6
REVIEW
Trixy David, Stephanie Ling, Anne Barton
Immune-mediated inflammatory diseases (IMIDs) are characterised by dysregulation of the normal immune response, which leads to inflammation. Together, they account for a high disease burden in the population, given that they are usually chronic conditions with associated co-morbidities. Examples include systemic lupus erythematosus, rheumatoid arthritis, Crohn's disease and type 1 diabetes. Since the advent of genome-wide association studies, evidence of considerable genetic overlap in the loci predisposing to a wide range of IMIDs has emerged...
January 12, 2018: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29327635/an-open-label-clinical-trial-of-thalidomide-in-nsaids-refractory-ankylosing-spondylitis
#7
Minhaj Rahim Choudhury, M Masudul Hassan, M Ekramul Kabir, M Golam Rabbani, Syed Atiqul Haq, Md Kasedur Rahman
No abstract text is available yet for this article.
January 12, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29325529/a-multiple-imputation-method-based-on-weighted-quantile-regression-models-for-longitudinal-censored-biomarker-data-with-missing-values-at-early-visits
#8
MinJae Lee, Mohammad H Rahbar, Matthew Brown, Lianne Gensler, Michael Weisman, Laura Diekman, John D Reveille
BACKGROUND: In patient-based studies, biomarker data are often subject to left censoring due to the detection limits, or to incomplete sample or data collection. In the context of longitudinal regression analysis, inappropriate handling of these issues could lead to biased parameter estimates. We developed a specific multiple imputation (MI) strategy based on weighted censored quantile regression (CQR) that not only accounts for censoring, but also missing data at early visits when longitudinal biomarker data are modeled as a covariate...
January 11, 2018: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/29324184/effects-of-non-steroidal-anti-inflammatory-drugs-on-serum-proinflammatory-cytokines-in-the-treatment-of-ankylosing-spondylitis
#9
Yong Yan, Tuan-Mao Guo, Chao Zhu
OBJECTIVE: This study was conducted to investigate the correlation between levels of serum proinflammatory cytokines and the clinical efficacy of non-steroidal anti-inflammatory drugs (NSAIDs) in patients with ankylosing spondylitis (AS). METHODS: A total of 148 AS patients were selected and received NSAID treatment. ELISA was used to assess cytokine levels, and patients were assigned into positively effective, effective, moderately effective, and ineffective groups...
January 11, 2018: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/29316959/ankylosing-spondylitis-kyphosis-surgical-correction-postoperative-evaluation-via-srs-22-domain-investigation
#10
Hao Zhang, XueSong Zhang, Fanqi Hu, Wenhao Hu, Yao Wang, Yongyu Hao
BACKGROUND: The SRS-22 is used to evaluate clinical outcomes in ankylosing spondylitis kyphosis patients. This study aimed to investigate the relationship between Scoliosis Research Society-22 (SRS-22) domains and satisfaction with management in patients who underwent surgical correction for ankylosing spondylitis kyphosis. The relationship between patient satisfaction and SRS-22 domain scores will feedback abundant information of therapeutic effect and significance for treatment guidance...
January 9, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29313553/have-the-yearly-trends-of-total-hip-arthroplasty-in-ankylosing-spondylitis-patients-decreased
#11
Lee Bloom, John J Kelly, Jared M Newman, Nipun Sodhi, Robert Pivec, Assem A Sultan, Neil V Shah, Jaiben George, Anton Khlopas, Kim L Stearns, Carl B Paulino, Michael A Mont
INTRODUCTION: Ankylosing spondylitis (AS) is characterized by spinal inflammation and structural damage, primarily to the axial skeleton and sacroiliac joints. Between 25% and 70% of patients may experience progressive peripheral joint involvement, which, despite advancement in pharmacologic therapy, may necessitate surgical intervention. Total hip arthroplasty (THA) yields improved pain and functional outcomes for AS patients with hip involvement. It is unclear whether the annual rates of patients undergoing THA have changed due to newer pharmacologic management...
December 22, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/29313272/tenascin-c-a-biomarker-of-disease-activity-in-early-ankylosing-spondylitis
#12
Latika Gupta, Shruti Bhattacharya, Amita Aggarwal
Monocytes of patients with ankylosing spondylitis (AS) over-express toll-like receptor (TLR) 4. Tenascin-C (TNC) is an endogenous TLR4 ligand. Thus, we studied the serum and synovial fluid levels of TNC in AS. TNC was measured in serum of 36 AS patients (ASAS 2010 criteria) and 39 healthy controls by ELISA. Twenty-two patients were followed up after 3 months of standard treatment. Five paired serum-synovial fluid samples were also analyzed. Disease activity was assessed by BASDAI, ASDAS, swollen joint count, ESR, and CRP...
January 8, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29310538/effect-of-education-and-telephone-counselling-on-adherence-to-treatment-and-challenges-experienced-in-anti-tnf-%C3%AE-treatment-a-pilot-study
#13
Ayse Ozkaraman, Guler Balcı Alparslan, Burcu Babadağ, Timucin Kaşifoğlu, Canan Baydemir
BACKGROUND: Anti TNF-α drugs used in the treatment of rheumatologic diseases have relatively more side effect potential, these drugs can only be effective in long-term use. OBJECTIVE: This study was conducted to examine the effects of education about the drug use and consultation by telephone calls on treatment adherence and drug-induced challenges in patients under "the first anti TNF-α treatment". METHODS: A total of of 32 patients were randomly assigned to a intervention group (n=17) and a control group (n=15)...
January 9, 2018: Contemporary Nurse
https://www.readbyqxmd.com/read/29309829/targeting-cytokines-in-reduction-of-depressive-symptoms-a-comprehensive-review
#14
REVIEW
Aisha S Shariq, Elisa Brietzke, Joshua D Rosenblat, Vishalinee Barendra, Zihang Pan, Roger S McIntyre
Heterogeneity in response to conventional antidepressants is a well-recognized limitation of evidence-based pharmacological treatments of major depressive disorder (MDD). Abnormal activation of inflammatory pathways is postulated as one likely mechanism contributing to treatment resistance in MDD. In a subset of depressed patients, the balance between pro- and anti-inflammatory cytokines is thought to be altered, causing mood symptoms due to inflammation, as seen in co-morbid depression associated with inflammatory conditions (e...
January 5, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29308631/rate-of-spinal-surgery-in-a-rapidly-aging-society-the-27-year-changes-in-miyagi-prefecture-japan
#15
Toshimi Aizawa, Shoichi Kokubun, Takashi Kusakabe, Hiroshi Ozawa, Yasuhisa Tanaka, Takeshi Hoshikawa, Ko Hashimoto, Haruo Kanno, Naoki Morozumi, Yutaka Koizumi, Chikashi Kawahara, Tetsuro Sato, Hironori Hyodo, Shinji Ogawa, Eiichi Murakami, Eiji Itoi
BACKGROUND: Japan has had a rapidly aging population during the past 30 years. This study aimed to investigate longitudinal changes in the surgical rate for spinal disorders in Miyagi Prefecture (2.35 million inhabitants) with a similar population composition to Japan. METHODS: Data of spinal surgeries were collected using the spine registry by Tohoku University Spine Society. Data on the annual number of spinal surgeries between 1988 and 2014 of all populations, in those aged ≧65 years old, in those aged ≧75 years old, and for each pathology were collected...
January 4, 2018: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/29308377/structural-equation-modeling-on-health-related-quality-of-life-of-patients-with-ankylosing-spondylitis
#16
Ae Ri Jang, Keum Seong Jang
Background: Ankylosing Spondylitis (AS) is a chronic, progressive, and inflammatory disease. The objective of this study was to construct a hypothetical model to determine factors affecting health-related quality of life (HRQOL) of AS patients (ASHRQOL). Methods: A survey was conducted on 275 patients who visited Chonnam National University Bitgoeul Hospital. Data of different variables were collected over two months in 2015. Results: A hypothetical model did not reach recommended level of fit verification...
October 2017: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/29308282/low-frequency-of-hla-b27-in-ankylosing-spondylitis-and-its-relationship-with-clinical-findings-in-patients-from-turkey
#17
Sevde Nur Fırat, Ayten Yazıcı, Barış Yılmazer, Fulya Coşan, Hakan Savlı, Ayşe Cefle
Objective: Human leukocyte antigen B27 (HLA-B27) is strongly associated with ankylosing spondylitis (AS). However, the association between clinical findings and HLA-B27 vary in terms of geographic area. This study aimed to determine the frequency of HLA-B27 positivity and its relationship with clinical findings. Material and Methods: All subjects fulfilling the modified New York diagnosis criteria for AS enrolled in study. The demographic data and histories of the patients were collected retrospectively from patient files...
December 2017: European Journal of Rheumatology
https://www.readbyqxmd.com/read/29307092/health-related-quality-of-life-outcomes-in-patients-with-rheumatoid-arthritis-and-ankylosing-spondylitis-after-tapering-biologic-treatment
#18
Ming-Han Chen, Mei-Hsuan Lee, Hsien-Tzung Liao, Wei-Sheng Chen, Chien-Chih Lai, Chang-Youh Tsai
Treatment with biological disease-modifying anti-rheumatic drugs (bDMARDs) for rheumatoid arthritis (RA) and ankylosing spondylitis (AS) is popular. The aim of this study was to investigate changes in the quality of life (QoL) in patients after receiving, tapering, or stopping bDMARD treatment. Three hundred and thirty patients with RA and 120 patients with AS were enrolled. Data on the patients receiving bDMARDs were obtained by self-completed questionnaires including the short-form 36 (SF-36) and Global Quality of Life (GQL) scale...
January 6, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29305072/analysis-of-risk-factors-for-sagittal-translation-after-pedicle-subtraction-osteotomy-in-ankylosing-spondylitis-patients
#19
Jin-Sung Park, Jaedong Kim, Il-Han Joo, Kyu-Dong Sim, Ye-Soo Park
BACKGROUND CONTEXT: Sagittal translation, a potential complication of pedicle subtraction osteotomy (PSO), can results in neurologic damage. However, few studies have been conducted on sagittal translation and its risk factors after PSO in patients with ankylosing spondylitis (AS). PURPOSE: To report cases of sagittal translation that developed after PSO in patients with AS with kyphotic deformity and to analyze risk factors for sagittal translation. STUDY DESIGN: A retrospective case-control study PATIENT SAMPLE: This study included 53 patients (58 cases) with AS who underwent PSO to correct their kyphotic deformity...
January 2, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29303701/increased-levels-of-serum-histone-h4-and-activated-protein-c-in-patients-with-active-rheumatoid-arthritis
#20
Wanchan Peng, Xianghui Liang, Yong Zhong, Yaou Zhou, Litao Hu, Wei Wang
OBJECTIVES: We aimed to examine the levels of serum H4 and activated protein C (APC) in rheumatoid arthritis (RA) and other autoimmune conditions, and investigate the associations between H4 or APC levels and disease activity indicators in RA. METHODS: Serum H4 and APC distribution was examined in samples from patients with RA, systemic lupus erythematosus (SLE), polymyositis (PM), and ankylosing spondylitis (AS), as well as in samples from healthy controls, using commercial ELISA kits...
December 27, 2017: Clinical and Experimental Rheumatology
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