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Paul Vespa, Daniel Hanley, Joshua Betz, Alan Hoffer, Johnathan Engh, Robert Carter, Peter Nakaji, Chris Ogilvy, Jack Jallo, Warren Selman, Amanda Bistran-Hall, Karen Lane, Nichol McBee, Jeffery Saver, Richard E Thompson, Neil Martin
BACKGROUND AND PURPOSE: Intracerebral hemorrhage (ICH) is a devastating disease without a proven therapy to improve long-term outcome. Considerable controversy about the role of surgery remains. Minimally invasive endoscopic surgery for ICH offers the potential of improved neurological outcome. METHODS: We tested the hypothesis that intraoperative computerized tomographic image-guided endoscopic surgery is safe and effectively removes the majority of the hematoma rapidly...
October 6, 2016: Stroke; a Journal of Cerebral Circulation
Kenneth J Hoffer, Giacomo Savini
PURPOSE: To investigate agreement between the ocular biometry measurements provided by a newer optical biometer, the AL-Scan (Nidek Co, Ltd., Gamagori, Japan) and those provided by the IOLMaster 500 (Carl Zeiss Meditec, Jena Germany), which are both based on partial coherence interferometry. METHODS: Axial length, corneal power, and anterior chamber depth (corneal epithelium to lens) were measured in 86 eyes of 86 patients scheduled for cataract surgery using both biometers...
October 1, 2016: Journal of Refractive Surgery
L John Hoffer, Line Robitaille, Nelda Swinton, Jason Agulnik, Victor Cohen, David Small, Carmela Pepe, Shaun Eintracht
BACKGROUND: Most patients attending cancer clinics have hypovitaminosis D. Correcting or preventing this abnormal condition could mitigate the emotional and physical complications of their disease, but clinical trials of vitamin D therapy in this setting are hindered by the unavailability of safe, effective and practical loading dose regimens. METHODS: In this single arm open-label pharmacokinetic trial, outpatients with advanced lung cancer consumed 20,000 IU vitamin D daily with the largest meal of the day for 14 days followed by 10,000 IU per day for a further 7 days...
October 6, 2016: Nutrition Journal
William E Pierson, Eric D Hoffer, Hannah E Keedy, Carrie L Simms, Christine M Dunham, Hani S Zaher
Termination of protein synthesis on the ribosome is catalyzed by release factors (RFs), which share a conserved glycine-glycine-glutamine (GGQ) motif. The glutamine residue is methylated in vivo, but a mechanistic understanding of its contribution to hydrolysis is lacking. Here, we show that the modification, apart from increasing the overall rate of termination on all dipeptides, substantially increases the rate of peptide release on a subset of amino acids. In the presence of unmethylated RFs, we measure rates of hydrolysis that are exceptionally slow on proline and glycine residues and approximately two orders of magnitude faster in the presence of the methylated factors...
September 27, 2016: Cell Reports
Oliver L Yeh, Karine D Bojikian, Mark A Slabaugh, Philip P Chen
PURPOSE: To examine refractive outcomes after phacoemulsification in eyes with prior trabeculectomy. DESIGN: Retrospective observational case-control study METHODS:: Comparison of eyes of glaucoma patients undergoing cataract surgery after trabeculectomy (study group) with a matched group with medically controlled glaucoma (control group). Laser interferometry was used to obtain ocular biometry. We measured the difference between the expected and actual postoperative refraction using third-generation and fourth-generation intraocular lens (IOL) prediction formulae (Haigis, Holladay 2, Hoffer Q, and SRK-T)...
September 21, 2016: Journal of Glaucoma
Toshiharu Mita, Hironobu Handa, Yoshimitsu Higashiura, George Japoshvili
BACKGROUND: Encyrtid secondary parasitoids of Delphacidae have not been recorded in Japan. However, they may play an important role in the rice ecosystem because they can reduce the number of Dryinidae, the natural enemies of rice planthoppers. NEW INFORMATION: We found two encyrtid species, Cheiloneurus exitiosus (Perkins, 1906) and Helegonatopus dimorphus (Hoffer, 1954), from rice paddies and the surrounding environment. Haplogonatopus oratorius (Westwood, 1833) and Anteon sp...
2016: Biodiversity Data Journal
Jody Hoffer Gittell
No abstract text is available yet for this article.
October 2016: Health Services Research
M Szczupak, M E Hoffer, S Murphy, C D Balaban
Traumatic brain injury is an increasingly common public health issue, with the mild variant most clinically relevant for this chapter. Common causes of mild traumatic brain injury (mTBI) include motor vehicle accidents, athletics, and military training/deployment. Despite a range of clinically available testing platforms, diagnosis of mTBI remains challenging. Symptoms are primarily neurosensory, and include dizziness, hearing problems, headaches, cognitive, and sleep disturbances. Dizziness is nearly universally present in all mTBI patients, and is the easiest symptom to objectify for diagnosis...
2016: Handbook of Clinical Neurology
Emily Filichia, Barry Hoffer, Xin Qi, Yu Luo
Accumulating evidence suggest mitochondria-mediated pathways play an important role in dopaminergic neuronal cell death in Parkinson's disease (PD). Drp1, a key regulator of mitochondrial fission, has been shown to be activated and translocated to mitochondria under stress, leading to excessive mitochondria fission and dopaminergic neuronal death in vitro. However, whether Drp1 inhibition can lead to long term stable preservation of dopaminergic neurons in PD-related mouse models remains unknown. In this study, using a classical MPTP animal PD model, we showed for the first time Drp1 activation and mitochondrial translocation in vivo after MPTP administration...
2016: Scientific Reports
Jing-Ya Wang, Ya-Ni Huang, Chong-Chi Chiu, David Tweedie, Weiming Luo, Chaim G Pick, Szu-Yi Chou, Yu Luo, Barry J Hoffer, Nigel H Greig, Jia-Yi Wang
No abstract text is available yet for this article.
2016: Journal of Neuroinflammation
Saadullah Khan, Imran Ullah, Abdul Nasir, C Arnoud Meijer, Marlies Laurense-Bik, Johan T den Dunnen, Claudia A L Ruivenkamp, Mariëtte J V Hoffer, Gijs W E Santen, Wasim Ahmad
Postaxial polydactyly (PAP) is one of the most common congenital malformations observed in the general population. However, it can also occur as part of a syndrome. Unbiased genetic screening techniques such as exome sequencing are highly appropriate methods to provide a molecular diagnosis in patients with polydactyly due to the large number of mutated genes associated with it. The present study describes a consanguineous family of Pakistani origin with PAP, speech impairment, hearing impairment of variable degree, and proportionate short stature with no prominent intellectual disability or ophthalmological abnormalities...
August 29, 2016: American Journal of Medical Genetics. Part A
Ling-Yu Yang, Nigel H Greig, Ya-Ni Huang, Tsung-Hsun Hsieh, David Tweedie, Qian-Sheng Yu, Barry J Hoffer, Yu Luo, Yu-Chieh Kao, Jia-Yi Wang
Traumatic brain injury (TBI) is a major cause of death and disability worldwide. Neuronal apoptosis in the hippocampus has been detected after TBI. The hippocampal dysfunction may result in cognitive deficits in learning, memory, and spatial information processing. Our previous studies demonstrated that a p53 inhibitor, pifithrin-α oxygen analogue (PFT-α (O)), significantly reduced cortical cell death, which is substantial following controlled cortical impact (CCI) TBI, and improved neurological functional outcomes via anti-apoptotic mechanisms...
August 20, 2016: Neurobiology of Disease
Yang Sheng, Emily Filichia, Elizabeth Shick, Kenzie L Preston, Karran A Phillips, Leslie Cooperman, Zhicheng Lin, Paul Tesar, Barry Hoffer, Yu Luo
INTRODUCTION: The dopaminergic (DA) system plays important roles in addiction. However, human DA neurons from drug-dependent subjects were not available for study until recent development in inducible pluripotent stem cells (iPSCs) technology. METHODS: In this study, we produced DA neurons differentiated using iPSCs derived from opioid-dependent and control subjects carrying different 3' VNTR (variable number tandem repeat) polymorphism in the human dopamine transporter (DAT or SLC6A3)...
August 2016: Brain and Behavior
George E Black, Kyle K Sokol, Robert Shawhan, Matthew J Eckert, Shashikumar Salgar, Shannon T Marko, Zachary S Hoffer, Matthew J Martin
BACKGROUND: Suspended animation-like states have been achieved in small animal models, but not in larger species. Inducing metabolic suppression and temporary oxygen-independence could enhance survivability of massive injury. Based on prior analyses of key pathways, we hypothesized that PI3-kinase inhibition (PI3-KI) would produce metabolic suppression without worsening organ injury or systemic physiology. METHODS: Twenty swine were studied using LY294002 (LY), a non-selective PI3-KI: Animals were assigned to Trauma only (TO, N=3); DMSO only (DMSO, N=4), LY drug only (LYO, N=3); and Drug + trauma (LY+T , N=10) groups...
August 18, 2016: Journal of Trauma and Acute Care Surgery
Kenneth J Hoffer, Peter C Hoffmann, Giacomo Savini
PURPOSE: To investigate agreement between the IOLMaster 700 based on swept-source optical coherence tomography (SS-OCT) and the Lenstar LS 900 based on optical low-coherence reflectometry (OLCR). SETTING: Private practice, Castrop-Rouxelle, Germany. DESIGN: Prospective evaluation of diagnostic test. METHODS: Axial length (AL), keratometry (K), anterior chamber depth (corneal epithelium to lens) (ACD), lens thickness, and central corneal thickness (CCT) were measured in 183 eyes of 183 patients...
August 2016: Journal of Cataract and Refractive Surgery
David L Cooke, Timothy L Cooke
PURPOSE: To evaluate the accuracy of 9 intraocular lens (IOL) calculation formulas using 2 optical biometers. SETTING: Private practice, Saint Joseph, Michigan, USA. DESIGN: Retrospective consecutive case series. METHODS: Nine IOL power formula predictions with observed refractions after cataract surgery were compared using 1 IOL platform. The performance of each formula was ranked for accuracy by machine and by axial length (AL)...
August 2016: Journal of Cataract and Refractive Surgery
Jeroen Breckpot, Marieke Vercruyssen, Eddy Weyts, Sean Vandevoort, Greet D'Haenens, Griet Van Buggenhout, Lore Leempoels, Elise Brischoux-Boucher, Lionel Van Maldergem, Alessandra Renieri, Maria Antonietta Mencarelli, Carla D'Angelo, Veronica Mericq, Mariette J Hoffer, Maithé Tauber, Catherine Molinas, Claudia Castiglioni, Nathalie Brison, Joris R Vermeesch, Marina Danckaerts, Pascal Sienaert, Koenraad Devriendt, Annick Vogels
BACKGROUND: Catatonia is a motor dysregulation syndrome co-occurring with a variety of psychiatric and medical disorders. Response to treatment with benzodiazepines and electroconvulsive therapy suggests a neurobiological background. The genetic etiology however remains largely unexplored. Copy Number Variants (CNV), known to predispose to neurodevelopmental disorders, may play a role in the etiology of catatonia. METHODS: This study is exploring the genetic field of catatonia through CNV analysis in a cohort of psychiatric patients featuring intellectual disability and catatonia...
September 2016: European Journal of Medical Genetics
Royce Ellen Clifford, Michael Hoffer, Rick Rogers
OBJECTIVE: Using Reactome, a curated Internet database, noise-induced hearing loss studies were aggregated into cellular pathways for organization of the emerging genomic and epigenetic data in the literature. DATA SOURCES: PubMed and, a relational data base program systematizing biological processes into interactive pathways and subpathways based on ontology, cellular constituents, gene expression, and molecular components. STUDY SELECTION: Peer-reviewed population and laboratory studies for the previous 15 years relating genomics and noise and hearing loss were identified in PubMed...
September 2016: Otology & Neurotology
Kathleen Campbell, Tanisha Hammill, Michael Hoffer, Jonathan Kil, Colleen Le Prell
The purpose of this article is to provide guidelines for determining a Significant Noise-Induced Threshold Shift in clinical trials involving human populations. The article reviews recommendations for the standards to be referenced for human subjects, equipment, test environment, and personnel. Additional guidelines for military populations are provided. Guidelines for the calibration of audiometers, sound booth noise levels, and immitance equipment are provided. In addition the guidance provides specific suggestions for the subjects history before study onset, and otoscopy...
September 2016: Otology & Neurotology
Jinhai Huang, Giacomo Savini, Kenneth J Hoffer, Hao Chen, Weicong Lu, Qingjie Hu, Fangjun Bao, Qinmei Wang
OBJECTIVE: To evaluate the precision of the measurements in healthy subjects obtained with a new optical biometer (OA-2000, Tomey, Nagoya, Japan) using swept-source optical coherence tomography (SS-OCT) and compare these measurements with those provided by the IOLMaster v5.4 (Carl Zeiss Meditec AG, Jena, Germany) using partial coherence interferometry (PCI). METHODS: Axial length (AL), keratometry (K) over 2.5 mm and 3.0 mm diameters, anterior chamber depth (ACD) (corneal epithelium to lens), lens thickness (LT), central corneal thickness and corneal diameter (CD) were measured with SS-OCT by two experienced operators...
August 8, 2016: British Journal of Ophthalmology
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