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https://www.readbyqxmd.com/read/28933212/impact-of-traumatic-brain-injury-on-dopaminergic-transmission
#1
Yuan-Hao Chen, Eagle Yi-Kung Huang, Tung-Tai Kuo, Jonathan Miller, Yung-Hsiao Chiang, Barry J Hoffer
Brain trauma is often associated with severe morbidity and is a major public health concern. Even when injury is mild and no obvious anatomic disruption is seen, many individuals suffer disabling neuropsychological impairments such as memory loss, mood dysfunction, substance abuse, and adjustment disorder. These changes may be related to subtle disruption of neural circuits as well as functional changes at the neurotransmitter level. In particular, there is considerable evidence that dopamine (DA) physiology in the nigrostriatal and mesocorticolimbic pathways might be impaired after traumatic brain injury (TBI)...
July 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28913996/intraocular-lens-power-calculation-after-refractive-surgery-a-comparative-analysis-of-accuracy-and-predictability
#2
Byeong Soo Kang, Jeong Mo Han, Joo Youn Oh, Mee Kum Kim, Won Ryang Wee
PURPOSE: To compare the accuracy of intraocular lens (IOL) power calculation using conventional regression formulae or the American Society of Cataract and Refractive Surgery (ASCRS) IOL power calculator for previous corneal refractive surgery. METHODS: We retrospectively reviewed 96 eyes from 68 patients that had undergone cataract surgery after keratorefractive surgeries. We calculated the formula with two approaches: IOL powers using the ASCRS IOL power calculator and IOL powers using conventional formulae with previous refractive data (Camellin, Jarade, Savini, and clinical history method) or without prior data (0, 2 and, 4 mm total mean power in topography, Wang-Koch-Maloney, Shammas, Seitz, and Maloney)...
June 29, 2017: Korean Journal of Ophthalmology: KJO
https://www.readbyqxmd.com/read/28913511/accuracy-of-formulae-for-secondary-intraocular-lens-power-calculations-in-pediatric-aphakia
#3
Fouad R Nakhli, Khaled Emarah, Laila Jeddawi
PURPOSE: To compare the accuracy of axial length vergence formulas versus refractive vergence formulas for secondary intraocular lens (IOL) implantation in pediatric aphakia. METHODS: This retrospective comparative study, evaluated 31 eyes of 31 patients aged ≤3.5 years, who had undergone secondary IOL implantation. The median absolute error (MedAE) was compared between axial length vergence formulas (Hoffer Q, Holladay I, SRK II, and SRK/T) and refractive vergence formulas (Lanchulev, Holladay R, Mackool, and Khan) as well as between formulas within the same vergence...
September 2017: Journal of Current Ophthalmology
https://www.readbyqxmd.com/read/28894835/the-use-of-oculomotor-vestibular-and-reaction-time-tests-to-assess-mild-traumatic-brain-injury-mtbi-over-time
#4
Michael E Hoffer, Carey Balaban, Mikhaylo Szczupak, James Buskirk, Hillary Snapp, James Crawford, Sean Wise, Sara Murphy, Kathryn Marshall, Constanza Pelusso, Sean Knowles, Alex Kiderman
OBJECTIVES: The objective of this work is to examine the outcomes of a set of objective measures for evaluating individuals with minor traumatic brain injury (mTBI) over the sub-acute time period. These methods involve tests of oculomotor, vestibular, and reaction time functions. This work expands upon published work examining these test results at the time of presentation. STUDY DESIGN: This study is a prospective age- and sex-matched controlled study. MATERIALS AND METHODS: The subject group was composed of 106 individuals with mTBI and 300 age- and sex-matched controls without a history of mTBI...
August 2017: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/28887901/meta-analysis-of-accuracy-of-intraocular-lens-power-calculation-formulas-in-short-eyes
#5
Qiwei Wang, Wu Jiang, Tiao Lin, Xiaohang Wu, Haotian Lin, Weirong Chen
IMPORTANCE: Intraocular lens (IOL) power selection is a critical factor affecting visual outcome after IOL implantation in short eyes. Many formulas have been developed to achieve a precise prediction of the IOL power. However, controversy regarding the accuracy remains. BACKGROUND: To investigate the accuracy of different IOL power calculation formulas in short eyes. DESIGN: Meta-analysis PARTICIPANTS: Patients with the axial length of eyes less than 22mm from previously reported studies...
September 9, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28886718/repositioning-drugs-for-traumatic-brain-injury-n-acetyl-cysteine-and-phenserine
#6
REVIEW
Barry J Hoffer, Chaim G Pick, Michael E Hoffer, Robert E Becker, Yung-Hsiao Chiang, Nigel H Greig
Traumatic brain injury (TBI) is one of the most common causes of morbidity and mortality of both young adults of less than 45 years of age and the elderly, and contributes to about 30% of all injury deaths in the United States of America. Whereas there has been a significant improvement in our understanding of the mechanism that underpin the primary and secondary stages of damage associated with a TBI incident, to date however, this knowledge has not translated into the development of effective new pharmacological TBI treatment strategies...
September 9, 2017: Journal of Biomedical Science
https://www.readbyqxmd.com/read/28885259/clinical-results-of-the-hoffer-h-5-formula-in-2707-eyes-first-5th-generation-formula-based-on-gender-and-race
#7
Kenneth J Hoffer, Giacomo Savini
No abstract text is available yet for this article.
2017: International Ophthalmology Clinics
https://www.readbyqxmd.com/read/28835226/intraocular-lens-power-calculation-using-standard-formulas-and-ray-tracing-after-dmek-in-patients-with-fuchs-endothelial-dystrophy
#8
Maged Alnawaiseh, Lars Zumhagen, André Rosentreter, Nicole Eter
BACKGROUND: The study presented here aims to optimize the accuracy of intraocular lens (IOL) power calculations in patients after DMEK by evaluation of the impact of the altered anterior/posterior corneal curvature relationship. METHODS: Scheimpflug-based Oculus Pentacam imaging was performed after DMEK surgery for Fuchs endothelial dystrophy. The IOL power was calculated for all patients by ray tracing, aiming for postoperative emmetropia. We also performed the IOL calculation using four third-generation formulas (SRK-T, Hoffer-Q, Holladay-1 and Haigis)...
August 23, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28817301/patients-views-of-a-behavioral-intervention-including-financial-incentives
#9
Judy A Shea, Aderinola Adejare, Kevin G Volpp, Andrea B Troxel, Darra Finnerty, Karen Hoffer, Thomas Isaac, Meredith Rosenthal, Thomas D Sequist, David A Asch
OBJECTIVES: Clinical trials are increasingly testing the effectiveness of paying patients' financial incentives for achieving desired clinical outcomes. Some researchers and providers are concerned that patient financial incentives will harm the doctor-patient relationship. How patients feel about these approaches, and these trials, is largely unknown. This study examined patients' perceptions of a compound behavioral and financial incentive intervention used in a large multicenter trial to lower low-density lipoprotein cholesterol (LDL-C), including their perceptions of benefits and challenges and the study's effect on patients' relationship with their primary care physicians (PCPs)...
June 2017: American Journal of Managed Care
https://www.readbyqxmd.com/read/28809660/longitudinal-study-of-changes-in-occupational-therapy-students-perspectives-on-frames-of-reference
#10
Brittany Hoffer Nash, Anita Witt Mitchell
We explored students' views of the value of frames of reference (FoR) as they progressed through the didactic portion of an occupational therapy program. Thirty-four occupational therapy students were provided with a definition of FoR and asked to provide overall thoughts and impressions about FoR and their value 4 times over a period of 15 mo. Data were analyzed using phenomenological traditions, including open coding and analysis of themes. Throughout the program, students' understanding of how to use FoR evolved as they learned to implement them in practice...
September 2017: American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association
https://www.readbyqxmd.com/read/28808644/the-comparative-study-of-refractive-index-variations-between-haigis-srk-t-and-hoffer-q-formulas-used-for-preoperative-biometry-calculation-in-patients-with-the-axial-length-25-mm
#11
Hasan Razmjoo, Hosein Atarzadeh, Neda Kargar, Mohammad Behfarnia, Kobra Nasrollahi, Ali Kamali
BACKGROUND: To compare refractive index variation between Hoffer-Q, Haigis and SRK/T formulas used for preoperative biometry calculation in patients with axial length >25 mm, undergoing cataract surgery. MATERIALS AND METHODS: This is a randomized clinical trial study was performed on 54 eyes of 54 patients with ages of 40-70 years old and axial length >25 mm classified into three groups that their IOL POWER were calculated by Haigis, SRK/T and Hoffer-Q formulas before undergoing cataract surgery...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28795993/results-of-the-first-prospective-multi-institutional-treatment-study-in-children-with-bilateral-wilms-tumor-aren0534-a-report-from-the-children-s-oncology-group
#12
MULTICENTER STUDY
Peter Ehrlich, Yuen Y Chi, Murali M Chintagumpala, Fred A Hoffer, Elizabeth J Perlman, John A Kalapurakal, Ann Warwick, Robert C Shamberger, Geetika Khanna, Tom E Hamilton, Ken W Gow, Arnold C Paulino, Eric J Gratias, Elizabeth A Mullen, James I Geller, Paul E Grundy, Conrad V Fernandez, Michael L Ritchey, James S Dome
OBJECTIVE: The Children's Oncology Group study AREN0534 aimed to improve event-free survival (EFS) and overall survival (OS) while preserving renal tissue by intensifying preoperative chemotherapy, completing definitive surgery by 12 weeks from diagnosis, and modifying postoperative chemotherapy based on histologic response. BACKGROUND: No prospective therapeutic clinic trials in children with bilateral Wilms tumors (BWT) exist. Historical outcomes for this group were poor and often involved prolonged chemotherapy; on NWTS-5, 4-year EFS for all children with BWT was 56%...
September 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28780778/iol-power-calculation-in-short-and-long-eyes
#13
Kenneth J Hoffer, Giacomo Savini
An analysis of the studies published in the past 50 years reveals that the Haigis, Hoffer Q, and Holladay 2 formulas are the best options for intraocular lens power prediction in short eyes (<22 mm). In long eyes (>26 mm), the Barrett Universal II, Haigis (with optimized constants), Olsen, and SRK/T formulas provide the most accurate outcomes for intraocular lens power prediction.
July 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28760110/response-to-we-support-elevated-protein-requirements-in-the-intensive-care-unit-but-need-new-solutions
#14
L John Hoffer
No abstract text is available yet for this article.
August 2017: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/28745861/mass-spectrometric-imaging-of-ceramides-tracks-therapeutic-response-in-traumatic-brain-injury
#15
Damon Christopher Barbacci, Aurélie Roux, Ludovic Muller, Shelley N Jackson, Jeremy Post, Kathrine Baldwin, Barry Hoffer, Carey Balaban, Shawn Gouty, Brian M Cox, Amina S Woods
Traumatic brain injury (TBI) is a serious public health problem and the leading cause of death in children and young adults. It also contributes to a substantial number of cases of permanent disability. As lipids make up over 50% of the brain mass and play a key role in both membrane structure and cell signaling, their profile is of particular interest. In this study, we show that advanced mass spectrometry imaging (MSI) has sufficient technical accuracy and reproducibility to demonstrate the anatomical distribution of 50 micron diameter microdomains that show changes in brain ceramide levels in a rat model of controlled cortical impact (CCI) 3 days post injury with and without treatment...
July 26, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28745252/-culturally-sensitive-communication-in-end-of-life-care-the-care-for-muslim-patients-as-an-example
#16
N de Graeff, C Savelkoul, A Köse, M Ghaly, C B M Hoffer, D H T Tjan
Suffering and death are an inevitable part of life. In our increasingly multicultural society, healthcare professionals are frequently confronted with ideas on suffering and death that are different from their own. As Muslims are the largest migrant group in the Netherlands, this article focuses specifically on their perspective, illustrated by a clinical case. The different experience of these phenomena, influenced by culture and religion, can lead to confusion and frustration for patients, their relatives, and healthcare professionals alike...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28741757/equivalent-missense-variant-in-the-foxp2-and-foxp1-transcription-factors-causes-distinct-neurodevelopmental-disorders
#17
Elliot Sollis, Pelagia Deriziotis, Hirotomo Saitsu, Noriko Miyake, Naomichi Matsumoto, Mariëtte J V Hoffer, Claudia A L Ruivenkamp, Mariëlle Alders, Nobuhiko Okamoto, Emilia K Bijlsma, Astrid S Plomp, Simon E Fisher
The closely related paralogues FOXP2 and FOXP1 encode transcription factors with shared functions in the development of many tissues, including the brain. However, while mutations in FOXP2 lead to a speech/language disorder characterized by childhood apraxia of speech (CAS), the clinical profile of FOXP1 variants includes a broader neurodevelopmental phenotype with global developmental delay, intellectual disability, and speech/language impairment. Using clinical whole-exome sequencing, we report an identical de novo missense FOXP1 variant identified in three unrelated patients...
July 25, 2017: Human Mutation
https://www.readbyqxmd.com/read/28696277/learning-from-adversity
#18
Robert B Bourret
Many two-component regulatory systems, including Escherichia coli PhoRB, are positively autoregulated, so stimuli result in an increase in the concentration of signaling proteins. When the quantity of signaling proteins depends on exposure history, how do past conditions affect future responses to stimuli? Hoffer et al. (J. Bacteriol. 183:4914-4917, 2001, https://doi.org/doi:10.1128/JB.183.16.4914-4917.2001) previously reported that E. coli bacteria "learn" from phosphate starvation and respond more rapidly to subsequent episodes of starvation...
September 15, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28694616/reoperation-in-spinal-dysraphism-does-it-help-in-reversing-the-neurological-deficits
#19
Praful Suresh Maste, Yadhu Kasetti Lokanath, Shambhulingappa S Mahantshetti
AIMS: After initial primary repair by inexperienced hands for the spectrum of pathological conditions in spinal dysraphism (SD), a few percentage of patients present with recurrent symptoms and worsening neurological status especially when primarily pathology is not identified and dealt properly. When the primary intradural tethering element is left untouched, worsening of symptoms is common. In this retrospective study, we tried to analyze the symptomatology, functional outcome at 1-2 months after the second surgery and associated complications...
July 2017: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/28681907/corneal-asphericity-and-iol-power-calculation-in-eyes-with-aspherical-iols
#20
Giacomo Savini, Kenneth J Hoffer, Piero Barboni, Domenico Schiano Lomoriello, Pietro Ducoli
PURPOSE: Given that a previous study found that corneal asphericity influences the refractive outcome of intraocular lens (IOL) power calculation by means of thin-lens formulas in eyes with spherical IOLs, the authors aimed to verify whether such influence can also be observed in eyes with aspherical IOLs. METHODS: In this retrospective comparative case series, IOL power was calculated with the Haigis, Hoffer Q, Holladay 1, and SRK/T formulas in two groups of eyes undergoing phacoemulsification and implantation of an aspherical IOL (Acrysof SN60WF; Alcon Laboratories, Inc...
July 1, 2017: Journal of Refractive Surgery
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