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Atheromatosis, imt, cardiovascular , carotid

Athanasios K Roumeliotis, Stefanos K Roumeliotis, Stylianos A Panagoutsos, Fotis Tsetsos, Marianthi Georgitsi, Vangelis Manolopoulos, Peristera Paschou, Ploumis S Passadakis
PURPOSE: Cardiovascular (CV) events are the first cause of death in patients with chronic renal disease (CKD) and in patients with type 2 diabetes mellitus (DM2). The combination of CKD and DM2 elevates the risk of both cardiovascular disease (CVD) and death in this high-risk population. Besides traditional risk factors, such as dyslipidemia, smoking, obesity, and carotid atherosclerosis, novel factors are under investigation such as genetic polymorphisms. Lipoxygenases (LOXs) and their genes are of critical importance in oxidative stress, inflammation, and atherosclerosis...
February 2018: International Urology and Nephrology
Ovidiu Mitu, Mihai Roca, Mariana Floria, Antoniu Octavian Petris, Mariana Graur, Florin Mitu
INTRODUCTION: The aim of this study is to evaluate the relationship and the accuracy of SCORE (Systematic Coronary Risk Evaluation Project) risk correlated to multiple methods for determining subclinical cardiovascular disease (CVD) in a healthy population. MATERIAL AND METHODS: This cross-sectional study included 120 completely asymptomatic subjects, with an age range 35-75 years, and randomly selected from the general population. The individuals were evaluated clinically and biochemical, and the SCORE risk was computed...
April 1, 2017: Clínica e Investigación en Arteriosclerosis
Maria Vittoria Arcidiacono, Montserrat Martinez-Alonso, Montserrat Belart, Ana Vilar, Marisa Martín, Lourdes Craver, Àngels Betriu, Dídac Mauricio, José Manuel Valdivielso, Elvira Fernández, Mercè Borràs
Chronic kidney disease (CKD) patients, characterized by traditional and nontraditional risk factors, are prone to develop atheromatosis and thus cardiovascular events and mortality. The angiogenesis of the adventitial vasa vasorum (aVV) surrounding the carotid has been described as the atheromatosis initiator. Therefore, the aim of the study was to (1) evaluate if the carotid aVV in CKD patients increases in comparison to its physiological value of healthy patients; (2) explore which traditional or nontraditional risk factor including inflammation, bone and mineral metabolism, and anemia could be related to the aVV angiogenesis...
2017: Mediators of Inflammation
H Triantafyllidi, D Benas, S Vlachos, A Schoinas, I Ikonomidis, G Pavlidis, L Palaiodimos, J Lekakis
OBJECTIVE: Target organ damage (TOD) evaluation in patients with arterial hypertension is necessary in order to estimate cardiovascular risk (CVR) and plan treatment. Increased carotid intima-media thickness (IMT), an index of TOD, represents the diffuse vascular atheromatosis. The integrity of endothelial glycocalyx (EG) plays a vital role in vascular permeability, inflammation and elasticity and finally to cardiovascular disease. Sideview Darkfield imaging allows for non-invasive automated estimation of EG dimensions based on the erythrocyte column distribution...
September 2016: Journal of Hypertension
Domingo Hernández, Javier Triñanes, Eduardo Salido, Sergio Pitti, Margarita Rufino, José Manuel González-Posada, Armando Torres
BACKGROUND: Kidney transplant recipients have high cardiovascular risk, and vascular inflammation may play an important role. We explored whether the inflammatory state in the vessel wall was related to carotid intima-media thickness (c-IMT) and patient survival following kidney transplantation. METHODS: In this prospective observational cohort study we measured c-IMT and expression of proinflammatory cytokines and adhesion molecules in the inferior epigastric artery in 115 kidney transplant candidates...
2015: PloS One
Maria Vittoria Arcidiacono, Esther Rubinat, Mercè Borras, Angels Betriu, Javier Trujillano, Teresa Vidal, Didac Mauricio, Elvira Fernández
OBJECTIVE: The early identification of the onset of subclinical atheromatosis is essential in reducing the high mortality risk from cardiovascular disease (CVD) worldwide. Although carotid intima-media thickness (cIMT) is the most commonly used early predictor of ongoing atherosclerosis, an experimental model of atherosclerosis, demonstrated that increases in adventitial microvessels (vasa vasorum (VV)) precede endothelial dysfunction. Using the reported accuracy of contrast-enhanced ultrasound (CEU) to measure carotid adventitial VV, this study assessed whether measurements of carotid adventitial VV serve as a marker of subclinical atherosclerotic lesions in a control population with none of the classical risk factors for CVD...
April 17, 2015: Cardiovascular Ultrasound
Aikaterini Arida, Evi Zampeli, George Konstantonis, Kalliope Fragiadaki, George D Kitas, Athanasios D Protogerou, Petros P Sfikakis
Rheumatoid arthritis (RA) associates with increased cardiovascular disease (CVD) mortality thought to be due to accelerated arterial disease. Different components of arterial disease, namely, atheromatosis, arteriosclerosis, and arterial wall hypertrophy, are differentially affected by classical CVD risk factors, which are highly prevalent in these patients. We hypothesized that RA disease per se may also differentially affect these components. Of 267 consecutive RA patients, we selected specifically those who were free of established CVD and CVD risk factors (18 %); of them, 41 patients (36 women, 49 ± 13 years) could be matched effectively 1:1 for age and gender to healthy controls...
May 2015: Clinical Rheumatology
Kimon S Stamatelopoulos, Katerina Kyrkou, Elda Chrysochoou, Helen Karga, Sofia Chatzidou, Georgios Georgiopoulos, Stellios Georgiou, Konstantinos Xiromeritis, Christos M Papamichael, Maria Alevizaki
BACKGROUND: Hashimoto's thyroiditis (HT) is an autoimmune disorder associated with increased cardiovascular risk, mainly as a result of accelerated atherosclerosis. The aim of this study was to determine the effect of HT on carotid atherosclerosis and arterial stiffness, as possible mediators of this vascular impairment. Menopausal status was also considered in this setting since HT is mainly prevalent in women. METHODS: Fifty-four women with HT and normal thyroid function (thyrotropin [TSH] < 4...
August 2009: Thyroid: Official Journal of the American Thyroid Association
Alejandra Alvarez, Julián Fernandez, Esteban Porrini, Patricia Delgado, Sergio Pitti, María José Vega, José Manuel González-Posada, Aurelio Rodríguez, Lourdes Pérez, Domingo Marrero, Desiré Luis, Silvia Velázquez, Domingo Hernández, Eduardo Salido, Armando Torres
BACKGROUND: Prediabetic glucose homeostasis alterations are important cardiovascular risk factors but their role in renal transplant recipients (RTR) has not been established. METHODS: In 172 RTRs without pretransplant or de novo diabetes, we measured carotid intima media thickness (c-IMT) and performed an oral glucose tolerance test (OGTT). RESULTS: In multivariate analysis, age, hypertension and male sex were independently associated with a c-IMT in the third tertile...
October 15, 2007: Transplantation
Cristina Gavrilovici, O Brumariu, A G Dimitriu, A Covic, L Boiculese, R Russu
Non invasive assessment of large arteries structure and function is a valuable tool for early detection of athero/arteriosclerosis and the cardiovascular risk. The vascular injury is mainly represented by increased arterial stiffness (increased pulse wave velocity--PWV), increased peripheral arteries reflectivity (Aix) and the occurrence of significant atheromatosis (increased clMT). Although well described in adult, there are few data in children regarding the impact of uremia on vascular structure and function...
April 2006: Revista Medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti Din Iaş̧i
Jolanta Szczepańiska Kostro, Joanna Tołwińska, Mirosława Urban, Maria Gardziejczyk, Barbara Głowińska
INTRODUCTION: Early atheromatic changes have been found in the carotid and the femoral arteries of young adults with growth hormone (GH) deficiency (GHD). It has been shown that adults with GHD have increased cardiovascular risk factors. The aim of this study was to compare atherosclerotic risk factors in children with GHD and a normal population. PATIENTS AND METHODS: Twenty-five patients (10 girls, 15 boys) with GHD qualified for GH replacement treatment were included in the study...
October 2004: Journal of Pediatric Endocrinology & Metabolism: JPEM
E J Diamantopoulos, E A Andreadis, M G Kakou, C V Vassilopoulos, I G Vlachonikolis, N A Gianna-Kopoulos, K E Tarassi, C A Papasteriades, A N Nicolaides
BACKGROUND: Inflammation plays an important role in the pathogenesis of atherosclerosis. The major histocompatibility complex, as expressed by the human leukocyte antigens (HLA) is considered to regulate the immune response. The aim of this study was to investigate the association of the HLA antigens with vascular remodeling estimated by the carotid intima-media thickness (IMT) in subjects with type 2 diabetes mellitus (DM). METHODS: We evaluated 197 patients with type 2 DM, 80 males and 117 females, mean age 61...
December 2002: International Angiology: a Journal of the International Union of Angiology
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