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Uric acid AND cardiovascular AND risk factor

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https://www.readbyqxmd.com/read/28217505/noncommunicable-disease-in-rural-india-are-we-seriously-underestimating-the-risk-the-nallampatti-noncommunicable-disease-study
#1
Krishnan Swaminathan, Ganesh Veerasekar, Sujatha Kuppusamy, Mohanraj Sundaresan, Ganesan Velmurugan, Nalla G Palaniswami
AIM: To assess the prevalence of noncommunicable diseases in a true rural farming population in South India and compare the data with the landmark contemporary Indian Council of Medical Research-India Diabetes (ICMR-INDIAB) study. METHODS: Local Ethics Committee approval and informed consent was obtained from all participants. Inclusion criteria were participants, aged ≥20 and ≤85 years, from Nallampatti, a classical farming village from Tamil Nadu state, India...
January 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28187897/the-application-of-a-decision-tree-to-establish-the-parameters-associated-with-hypertension
#2
Maryam Tayefi, Habibollah Esmaeili, Maryam Saberi Karimian, Alireza Amirabadi Zadeh, Mahmoud Ebrahimi, Mohammad Safarian, Mohsen Nematy, Seyed Mohammad Reza Parizadeh, Gordon A Ferns, Majid Ghayour-Mobarhan
INTRODUCTION: Hypertension is an important risk factor for cardiovascular disease (CVD). The goal of this study was to establish the factors associated with hypertension by using a decision-tree algorithm as a supervised classification method of data mining. METHODS: Data from a cross-sectional study were used in this study. A total of 9078 subjects who met the inclusion criteria were recruited. 70% of these subjects (6358 cases) were randomly allocated to the training dataset for the constructing of the decision-tree...
February 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28181738/a-comparison-of-the-effects-of-diets-high-in-animal-or-plant-protein-on-metabolic-and-cardiovascular-markers-in-type-2-diabetes-a-randomized-clinical-trial
#3
Stephanie Sucher, Mariya Markova, Silke Hornemann, Olga Pivovarova, Natalia Rudovich, Ralph Thomann, Rosemarie Schneeweiss, Sascha Rohn, Andreas F H Pfeiffer
AIMS: High animal protein diets support body weight and glucose control but may induce insulin resistance and type 2 diabetes (T2DM) while plant protein based diets appear to be metabolically advantageous and reduce cardiovascular events. We therefore compared high animal versus plant protein diets differing in amino acid composition in people with T2DM. MATERIALS AND METHODS: We compared isocaloric diets containing 30% of energy (E%) either as animal (AP) or plant (PP) protein, using newly developed plant protein enriched foods, both combined with 30 E% fat and 40 E% carbohydrates in 44 patients with T2DM over six weeks in a randomized parallel group study...
February 9, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28178136/a-higher-baseline-plasma-uric-acid-level-is-an-independent-predictor-of-arterial-stiffness-a-community-based-prospective-study
#4
Xiao-Han Ding, Xiaona Wang, Ruihua Cao, Xu Yang, Wenkai Xiao, Yun Zhang, Yongyi Bai, Hongmei Wu, Ping Ye
Hyperuricemia has been demonstrated to be a risk factor for cardiovascular diseases. Though the association between uric acid (UA) and arterial stiffness has been investigated previously in patients with basic diseases, the predictive value of baseline UA level for arterial stiffness has not been conducted. We aimed at identifying the predictive role of UA for arterial stiffness prospectively.A longitudinal follow-up study in a routine health check-up population was performed with an average follow-up of 4...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28129213/hyperuricemia-as-an-independent-risk-factor-for-major-cardiovascular-events-a-10-year-cohort-study-from-southern-italy
#5
Vincenzo Capuano, Federica Marchese, Rocco Capuano, Sergio Torre, Anna G Iannone, Eduardo Capuano, Norman Lamaida, Matteo Sonderegger, Ernesto Capuano
AIMS: To date, whether hyperuricemia may represent a marker or an independent risk factor for cardiovascular disease remains unclear. This study aimed at assessing the role of hyperuricemia in the onset of major cardiovascular events (MACE). METHODS: Baseline clinical data were collected through a 1998/1999 longitudinal survey as part of the larger Valle dell'Irno Prevenzione Project. Ten years later, MACE incidence was evaluated. RESULTS: A total of 1175 patients (50% men, aged 25-74 years) completed the study...
March 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/28105870/association-of-serum-uric-acid-with-high-sensitivity-c-reactive-protein-in-postmenopausal-women
#6
A Raeisi, A Ostovar, K Vahdat, P Rezaei, H Darabi, D Moshtaghi, I Nabipour
OBJECTIVES: To explore the independent correlation between serum uric acid and low-grade inflammation (measured by high-sensitivity C-reactive protein, hs-CRP) in postmenopausal women. METHODS: A total of 378 healthy Iranian postmenopausal women were randomly selected in a population-based study. Circulating hs-CRP levels were measured by highly specific enzyme-linked immunosorbent assay method and an enzymatic calorimetric method was used to measure serum levels of uric acid...
February 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28105697/association-of-hematocrit-with-blood-pressure-and-hypertension
#7
Marzieh Emamian, Seyed Mahdi Hasanian, Maryam Tayefi, Moniba Bijari, Faeze Movahedian Far, Mojtaba Shafiee, Amir Avan, Alireza Heidari-Bakavoli, Mohsen Moohebati, Mahmoud Ebrahimi, Sousan Darroudi, Parvin Zamani, Mahmoud Reza Azarpazhooh, Mohsen Nematy, Mohammad Safarian, Gordon A Ferns, Habibollah Esmaeili, Mohammad Reza Parizadeh, Majid Ghayour-Mobarhan
BACKGROUND: Hypertension (HTN) is a risk factor for stroke, renal failure, and cardiovascular disease. The association between biochemical and hematological parameters with high blood pressure may provide a more precise approach to risk prediction conferred by HTN in these patients. OBJECTIVE: The aim of current study was to explore whether biochemical and hematological parameters are associated with HTN in a cohort study with a 7-year follow-up. MATERIALS AND METHODS: A total of 9808 individuals were enrolled and recruited as part of the Mashhad Stroke and Heart Atherosclerotic Disorders (MASHAD) cohort study, and biochemical and hematological factors were measured in all subjects...
January 20, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28095793/genetic-variation-underlying-renal-uric-acid-excretion-in-hispanic-children-the-viva-la-familia-study
#8
Geetha Chittoor, Karin Haack, Nitesh R Mehta, Sandra Laston, Shelley A Cole, Anthony G Comuzzie, Nancy F Butte, V Saroja Voruganti
BACKGROUND: Reduced renal excretion of uric acid plays a significant role in the development of hyperuricemia and gout in adults. Hyperuricemia has been associated with chronic kidney disease and cardiovascular disease in children and adults. There are limited genome-wide association studies associating genetic polymorphisms with renal urate excretion measures. Therefore, we investigated the genetic factors that influence the excretion of uric acid and related indices in 768 Hispanic children of the Viva La Familia Study...
January 17, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/28088910/sodium-glucose-cotransporter-2-inhibitors-sglt2i-their-role-in-cardiometabolic-risk-management
#9
Niki Katsiki, Dimitri P Mikhailidis, Michael J Theodorakis
BACKGROUND: Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are a novel category of oral antidiabetic drugs that inhibit renal glucose reabsorption and increase renal glucose excretion, thus lowering plasma glucose levels. This unique mechanism of SGLT2i action is insulin independent, thus improving glycemic control without promoting hypoglycemia in the absence of exogenously administered insulin. METHODS: The present narrative review addresses the putative associations between SGLT2i and several cardiovascular (CV) and microvascular risk factors, as well as their effects on cardiac and renal function...
January 13, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28066631/serum-uric-acid-levels-and-cardiovascular-disease-the-gordian-knot
#10
COMMENT
Efrén Martínez-Quintana, Antonio Tugores, Fayna Rodríguez-González
Hyperuricemia is defined as serum uric acid level of more than 7 mg/dL and blood levels of uric acid are causally associated with gout, as implicated by evidence from randomized clinical trials using urate lowering therapies. Uric acid as a cardiovascular risk factor often accompanies metabolic syndrome, hypertension, diabetes, dyslipidemia, chronic renal disease, and obesity. Despite the association of hyperuricemia with cardiovascular risk factors, it has remained controversial as to whether uric acid is an independent predictor of cardiovascular disease...
November 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28062372/uric-acid-may-be-protective-against-cognitive-impairment-in-older-adults-but-only-in-those-without-cardiovascular-risk-factors
#11
Busra Tuven, Pinar Soysal, Gulcin Unutmaz, Derya Kaya, Ahmet Turan Isik
Uric acid (UA) may not only prevent development of cognitive dysfunction owing to its antioxidant efficacy, but also may worsen cognitive functions by gaining pro-oxidant character. The present study attempts to uncover this paradoxical association between UA and cognitive impairment in elderly. 1374 elderly patients were retrospectively evaluated and included in the study. Participants underwent determination of circulating UA levels and comprehensive geriatric assessment. A serum UA concentration≥7.0mg/dL in males and ≥5...
January 4, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28057563/uric-acid-and-endothelial-function-in-elderly-community-dwelling-subjects
#12
Andrea Ticinesi, Fulvio Lauretani, Gian Paolo Ceda, Carmelinda Ruggiero, Luigi Ferrucci, Rosalia Aloe, Anders Larsson, Tommy Cederholm, Lars Lind, Tiziana Meschi, Marcello Maggio
The role of serum uric acid (SUA), an inflammatory agent and potential mediator of cardiovascular diseases, in endothelial function (EF) has been tested only in middle-aged subjects affected by specific diseases. Our aim was to assess the relationship between SUA and measures of EF in a cohort of elderly community-dwellers. This study involved 424 males and 426 females aged 70years from the Prospective Study of the Vasculature in Uppsala Seniors (PIVUS), having complete data on SUA and EF assessed by flow-mediated vasodilation (FMD) and by intra-arterial infusion of acetylcholine (endothelium-dependent vasodilation, EDV) and sodium nitroprusside (endothelium-independent vasodilation, EIDV)...
January 2, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28052754/the-burden-of-major-adverse-cardiac-events-in-patients-with-coronary-artery-disease
#13
I-Ting Tsai, Chao-Ping Wang, Yung-Chuan Lu, Wei-Chin Hung, Cheng-Ching Wu, Li-Fen Lu, Fu-Mei Chung, Chia-Chang Hsu, Yau-Jiunn Lee, Teng-Hung Yu
BACKGROUND: Patients with a history of cardiovascular disease are at high risk of developing secondary major adverse cardiac events (MACE). This study aimed to identify independent predictors of MACE after hospital admission which could be used to identify of high-risk patients who may benefit from preventive strategies. METHODS: This study included 1,520 consecutive patients with coronary artery disease (CAD) (654 with acute coronary syndrome (ACS) and 866 with elective percutaneous coronary intervention (PCI) patients) who received PCI and/or stenting...
January 4, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28051185/serum-uric-acid-levels-are-associated-with-obesity-but-not-cardio-cerebrovascular-events-in-chinese-inpatients-with-type-2-diabetes
#14
Ming-Yun Chen, Cui-Chun Zhao, Ting-Ting Li, Yue Zhu, Tian-Pei Yu, Yu-Qian Bao, Lian-Xi Li, Wei-Ping Jia
We aim to explore the associations between serum uric acid (SUA) and obesity and cardio-cerebrovascular events (CCEs) in Chinese inpatients with type 2 diabetes mellitus (T2DM). 2 962 inpatients with T2DM were stratified into quartile based on SUA concentrations. There were significant increases in the prevalence of both obesity (32.6%, 41.9%, 50.1%, and 62.8%, respectively, p < 0.001 for trend) and severe obesity (0.4%, 0.6%, 0.8%, and 1.3%, respectively, p < 0.001 for trend) across the SUA quartiles...
January 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28018129/relationship-between-fev1-and-cardiovascular-risk-factors-in-general-population-without-airflow-limitation
#15
Jeong Hyeon Lee, Yun-Seong Kang, Yun-Jeong Jeong, Young-Soon Yoon, Won Gun Kwack, Jin Young Oh
Purpose. We aimed to determine the value of lung function measurement for predicting cardiovascular (CV) disease by evaluating the association between FEV1 (%) and CV risk factors in general population. Materials and Methods. This was a cross-sectional, retrospective study of subjects above 18 years of age who underwent health examinations. The relationship between FEV1 (%) and presence of carotid plaque and thickened carotid IMT (≥0.8 mm) was analyzed by multiple logistic regression, and the relationship between FEV1 (%) and PWV (%), and serum uric acid was analyzed by multiple linear regression...
2016: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/27998159/relationship-between-cystatin-c-retinol-binding-protein-4-and-framingham-risk-score-in-healthy-postmenopausal-women
#16
Aleksandra Klisic, Jelena Kotur-Stevuljevic, Nebojsa Kavaric, Marija Matic
BACKGROUND: We aimed to examine the relationship between high levels of cystatin C, retinol-binding protein 4 (RBP4) and cardiovascular risk score [determined by Framingham Risk Score (FRS)] in postmenopausal women. METHODS: A total of apparently healthy 129 postmenopausal women (mean age 57.1 ± 4.6 years) were included. Serum cystatin C, RBP4, glucose, lipid parameters, creatinine, uric acid and high sensitivity C-reactive protein (hsCRP) were determined. Anthropometric parameters and blood pressure were also obtained...
December 2016: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/27978810/asymptomatic-hyperuricemia-is-not-an-independent-risk-factor-for-cardiovascular-events-or-overall-mortality-in-the-general-population-of-the-busselton-health-study
#17
Johannes Nossent, Warren Raymond, Mark Divitini, Matthew Knuiman
BACKGROUND: To investigate the impact of uric acid (UA) levels on cardiovascular disease and mortality at a population level. METHODS: Prospective analysis of baseline serum UA measurement and 15 year follow-up data from the Busselton Health Survey (n = 4,173), stratified by existence or absence of baseline cardiovascular disease. Outcomes were ascertained from state-wide hospital discharge and mortality registries. Cox regression produced adjusted hazard ratios (HR) for UA level as continuous and categorical (low, medium, high) predictor for cardiovascular events (CVE) and mortality...
December 15, 2016: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/27977580/ideal-cardiovascular-health-and-incident-hypertension-the-longitudinal-community-based-kailuan-study
#18
COMPARATIVE STUDY
Hai Yan Zhao, Xiao Xue Liu, An Xin Wang, Yun Tao Wu, Xiao Ming Zheng, Xiao Hong Zhao, Kai Cui, Chun Yu Ruan, Cheng Zhi Lu, Jost B Jonas, Shou Ling Wu
Ideal cardiovascular health (CVH) has been defined by the American Heart Association as the absence of disease and presence of 7 key health factors. Since it is unknown whether cumulative exposure to CVH reduces the risk of developing arterial hypertension, we prospectively examined the potential association between cumulative CVH (cumCVH) score (except for blood pressure metrics) and incident hypertension.Of the 101,510 participants with an age range of 18 to 98 years in this longitudinal community-based Kailuan study, our cohort included those 15,014 participants without hypertension at baseline and who had follow-up examinations 2, 4, and 6 years later...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27924211/circulating-mir-126-and-mir-499-reflect-progression-of-cardiovascular-disease-correlations-with-uric-acid-and-ejection-fraction
#19
Masoud Khanaghaei, Fereshtah Tourkianvalashani, Seyedhossein Hekmatimoghaddam, Nasrin Ghasemi, Mahdi Rahaie, Vahid Khorramshahi, Akhtar Sheikhpour, Zahra Heydari, Fatemeh Pourrajab
BACKGROUND: The aim of this study was to assess plasma levels of endothelium- and heart-associated microRNAs (miRNAs) miR-126 and miR-499, respectively, using quantitative reverse transcriptase polymerase chain reaction. METHODS: A two-step analysis was conducted on 75 patients undergoing off-pomp coronary artery bypass graft (CABG) surgery. Five biomarkers of inflammation and cardiac injury were assessed in addition to the above-mentioned miRNAs. RESULTS: Plasma concentrations of miRNAs were found to be significantly correlated with plasma levels of cardiac troponin I (cTnI) (miR-499, r 0...
January 2016: Heart International
https://www.readbyqxmd.com/read/27916816/blueberry-consumption-affects-serum-uric-acid-concentrations-in-older-adults-in-a-sex-specific-manner
#20
Carol L Cheatham, Itzel Vazquez-Vidal, Amanda Medlin, V Saroja Voruganti
Blueberries are rich in antioxidants and may protect against disease. Uric acid accounts for about 50% of the antioxidant properties in humans. Elevated levels of serum uric acid (SUA) or hyperuricemia is a risk factor for cardiovascular disease (CVD). The aim was to determine the effect of blueberries on SUA in older adults. Participants (n = 133, 65-80 years) experiencing mild cognitive impairment (MCI) were randomized in a double-blind 6-month clinical trial to either blueberry or placebo. A reference group with no MCI received no treatment...
November 29, 2016: Antioxidants (Basel, Switzerland)
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