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Uric acid AND cardiovascular AND risk factor

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https://www.readbyqxmd.com/read/29351480/mechanistically-different-effects-of-fat-and-sugar-on-insulin-resistance-hypertension-and-gut-microbiota-in-rats
#1
Sara Ramos-Romero, Mercè Hereu, Lidia Atienza, Josefina Casas, Olga Jáuregui, Susana Amézqueta, Gabriel Dasilva, Isabel Medina, Maria Rosa Nogués, Marta Romeu, Josep Lluís Torres
Insulin resistance (IR) and impaired glucose tolerance (IGT) are the first manifestations of diet-induced metabolic alterations leading to type-2 diabetes, while hypertension is the deadliest risk factor of cardiovascular disease. The roles of dietary fat and fructose in the development of IR, IGT and hypertension are controversial. We tested the long-term effects of an excess of fat or sucrose (fructose/glucose) on healthy male Wistar Kyoto (WKY) rats. Fat affects IR and IGT earlier than fructose through low-grade systemic inflammation evidenced by liver inflammatory infiltration, increased levels of plasma interleukin-6, prostaglandin E2 and reduced levels of protective short-chain fatty acids without triggering hypertension...
January 2, 2018: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29342419/investigation-of-the-transport-of-xanthine-dehydrogenase-inhibitors-by-the-urate-transporter-abcg2
#2
Makiko Nakamura, Kyoko Fujita, Yu Toyoda, Tappei Takada, Hiroshi Hasegawa, Kimiyoshi Ichida
Hyperuricemia induces gout and kidney stones and accelerates the progression of renal and cardiovascular diseases. Adenosine 5'-triphosphate-binding cassette subfamily G member 2 (ABCG2) is a urate transporter, and common dysfunctional variants of ABCG2, non-functional Q126X (rs72552713) and semi-functional Q141K (rs2231142), are risk factors for hyperuricemia and gout. A recent genome wide association study suggested that allopurinol, a serum uric acid-lowering drug that inhibits xanthine dehydrogenase, is a potent substrate of ABCG2...
November 22, 2017: Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/29319008/cardiovascular-risk-factors-in-noise-exposed-workers-in-china-small-area-study
#3
Xiaoyuan Wu, Daya Yang, Wendong Fan, Chunyue Fan, Guifu Wu
INTRODUCTION: The aim of the present study was to evaluate whether there are changes in cardiovascular risk factors among noise-exposed workers and to explore the possible mechanisms of a long-term noise exposure leading to cardiovascular disease and the sex differences of cardiovascular risk factors in this population. MATERIALS AND METHODS: Two hundred workers engaged in noise-related work, and a control group of 200 nonnoise-exposed workers hospitalized for occupational health examination were assigned into the study...
November 2017: Noise & Health
https://www.readbyqxmd.com/read/29317200/hyperuricemia-enhances-intracellular-urate-accumulation-via-down-regulation-of-cell-surface-bcrp-abcg2-expression-in-vascular-endothelial-cells
#4
Hisakazu Komori, Kazuyuki Yamada, Ikumi Tamai
Hyperuricemia has been recognized as an independent risk factor for cardiovascular disease. Urate stimulates NADPH oxidase and induces production of reactive oxygen species (ROS); consequently, intracellular urate accumulation can induce oxidative stress leading to endothelial dysfunction. Here, we studied the mechanism involved, using human umbilical vascular endothelial cells (HUVEC) as a model. Pretreatment with 15mg/dL unlabeled uric acid (corresponding to hyperuricemia) resulted in increased uptake of [14C]uric acid at steady-state by HUVEC, whereas pretreatment with 5mg/dL uric acid (in the normal serum concentration range) did not...
January 6, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29306459/serum-uric-acid-levels-are-associated-with-cardiovascular-risk-score-a-post-hoc-analysis-of-the-eurika-study
#5
Claudio Borghi, Fernando Rodriguez-Artalejo, Guy De Backer, Jean Dallongeville, Jesús Medina, Javier Nuevo, Eliseo Guallar, Joep Perk, José R Banegas, Florence Tubach, Carine Roy, Julian P Halcox
BACKGROUND: Reports are conflicting on whether serum uric acid (sUA) levels are independently associated with increased cardiovascular (CV) death risk. METHODS: This post hoc analysis assessed the relationship between sUA levels and CV death risk score in 7531 patients from the cross-sectional, multinational EURIKA study (NCT00882336). Patients had at least one CV risk factor but no clinical CV disease. Ten-year risk of CV death was estimated using SCORE-HDL and SCORE algorithms, categorized as low (<1%), intermediate (1% to <5%), high (≥5% to <10%) or very high (≥10%)...
February 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29278921/management-of-hyperuricemia-through-dietary-polyphenols-as-a-natural-medicament-a-comprehensive-review
#6
Arshad Mehmood, Lei Zhao, Chengtao Wang, Muhammad Nadeem, Ali Raza, Nawazish Ali, Amjad Abbas Shah
Hyperuricemia, a condition due to high serum uric acid level and is notorious to health. It is considered to be a potent risk factor for gout and dramatically associated in the development of many chronic diseases such as malignant tumor, cardiovascular disorders and renal failure. Modern innovative medicinal and therapeutic interventions are underlying these days to combat hyperuricemia. Previously reported studies revealed the significant impact of dietary polyphenols (e.g. anthocyanins, phenolic acids, flavonoids etc...
December 26, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29275349/association-between-serum-uric-acid-and-atrial-fibrillation-a-cross-sectional-community-based-study-in-china
#7
Yue Chen, Yunlong Xia, Xu Han, Yiheng Yang, Xiaomeng Yin, Jing Qiu, Henghui Liu, Yong Zhou, Ying Liu
OBJECTIVES: To investigate the effects of gender on the association of serum uric acid (SUA) levels and atrial fibrillation (AF) prevalence in a community-based Chinese population. SETTING: Data were obtained from annual Jidong Oilfield employee and family member health checkups. The Jidong community is geographically located in Tangshan City in northern China. PARTICIPANTS: A total of 9078 residents were invited to take part in the survey and provided informed consents...
December 22, 2017: BMJ Open
https://www.readbyqxmd.com/read/29246629/one-year-safety-and-efficacy-of-inosine-to-increase-the-serum-urate-level-for-patients-with-parkinson-s-disease-in-japan
#8
Hirotaka Iwaki, Rina Ando, Noriyuki Miyaue, Satoshi Tada, Tomoaki Tsujii, Hayato Yabe, Noriko Nishikawa, Masahiro Nagai, Masahiro Nomoto
BACKGROUND: Epidemiological studies have repeatedly reported that increased serum urate level is associated with a slower progress of Parkinson's disease (PD). The urate precursor, inosine, raises the serum urate level and is therefore a candidate for a disease modifying treatment. However, an elevated serum urate level is a risk factor for gout, urolithiasis, and cardiovascular diseases. Although there have been previous clinical studies, the use of inosine in a clinical setting is still limited, and its safety is unclear, especially in an Asian population...
December 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29203632/uric-acid-is-a-strong-risk-marker-for-developing-hypertension-from-prehypertension-a-5-year-japanese-cohort-study
#9
Masanari Kuwabara, Ichiro Hisatome, Koichiro Niwa, Shigeko Hara, Carlos A Roncal-Jimenez, Petter Bjornstad, Takahiko Nakagawa, Ana Andres-Hernando, Yuka Sato, Thomas Jensen, Gabriela Garcia, Bernardo Rodriguez-Iturbe, Minoru Ohno, Miguel A Lanaspa, Richard J Johnson
Prehypertension frequently progresses to hypertension, a condition associated with high morbidity and mortality from cardiovascular diseases and stroke. However, the risk factors for developing hypertension from prehypertension remain poorly understood. We conducted a retrospective cohort study using the data from 3584 prehypertensive Japanese adults (52.1±11.0 years, 2081 men) found to be prehypertensive in 2004 and reexamined in 2009. We calculated the cumulative incidences of hypertension over 5 years, examined risk factors, and calculated odds ratios (ORs) for developing hypertension after adjustments for age, sex, body mass index, smoking and drinking habits, baseline systolic and diastolic blood pressure, pulse rate, diabetes mellitus, dyslipidemia, chronic kidney disease, and serum uric acid levels...
December 4, 2017: Hypertension
https://www.readbyqxmd.com/read/29154722/association-of-kidney-function-and-waist-circumference-with-uric-acid-levels-in-south-africans
#10
Nomandla Daphne Madala, Thozama Dubula, Alain Guy Honoré Assounga, Saraladevi Naicker
BACKGROUND: Recent evidence that hyperuricemia is associated with incident chronic kidney disease (CKD) provides a potential therapeutic target for CKD that has not been explored in Africans. With hyperuricemia and gout increasing globally, we sought to determine their prevalence in South Africans with varying kidney function levels. METHODS: This was a cross-sectional study of ambulatory adult patients presenting at a General Internal Medicine Outpatients Clinic between September 2012 and March 2014...
November 20, 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/29132945/uric-acid-and-the-risks-of-kidney-failure-and-death-in-individuals-with-ckd
#11
Anand Srivastava, Arnaud D Kaze, Ciaran J McMullan, Tamara Isakova, Sushrut S Waikar
BACKGROUND: Serum uric acid concentrations increase in chronic kidney disease (CKD) and may lead to tubular injury, endothelial dysfunction, oxidative stress, and intrarenal inflammation. Whether uric acid concentrations are associated with kidney failure and death in CKD is unknown. STUDY DESIGN: Prospective observational cohort study. SETTINGS & PARTICIPANTS: 3,885 individuals with CKD stages 2 to 4 enrolled in the Chronic Renal Insufficiency Cohort (CRIC) between June 2003 and September 2008 and followed up through March 2013...
November 10, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29124773/consumption-of-orange-fermented-beverage-improves-antioxidant-status-and-reduces-peroxidation-lipid-and-inflammatory-markers-in-healthy-humans
#12
Blanca Escudero-López, Ángeles Ortega, Isabel Cerrillo, María-Rosario Rodríguez-Griñolo, Rocío Muñoz-Hernández, Hada C Macher, Franz Martín, Dámaso Hornero-Méndez, Pedro Mena, Daniele Del Rio, María-Soledad Fernández-Pachón
BACKGROUND: Alcoholic fermentation of fruits has generated novel products with high concentrations of bioactive compounds and moderate alcohol content. The aim of this study was to evaluate the potential effect on cardiovascular risk factors of the regular consumption by healthy humans of a beverage obtained by alcoholic fermentation and pasteurization of orange juice. RESULTS: Thirty healthy volunteers were enrolled in a randomized controlled study. The experimental group (n=15) drank 500 mL orange beverage (OB) day(-1) for 2 weeks (intervention phase), followed by a 3-week washout phase...
November 9, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29104632/fucoidan-elevates-surface-organic-cation-transporter-2-expression-via-upregulation-of-protein-kinase-a-in-uric-acid-nephropathy
#13
Xinlin Wu, Miansheng Yan, Taoli Liu, Jiantang Liao, Jianqing Zhang, Shuqing Chen, Wei Deng, Shijun Zhang, Baoguo Sun, Houming Zhou, Bin Ke
Uric acid nephropathy (UAN) is caused by excessive uric acid, and is a key risk factor for uric acid nephrolithiasis, gouty arthritis, renal diseases and cardiovascular diseases. The present study aimed to evaluate the protective effect of fucoidan, a sulfated polysaccharide component of brown algae, on UAN and to elucidate the underlying molecular mechanism. A rat model of UAN was induced by adenine treatment, and rats were then randomly assigned to control, model or fucoidan treatment groups. Hematoxylin and eosin staining of the kidney tissues of rats with UAN was subjected to conventional morphological evaluation...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29103322/prehypertension-and-high-serum-uric-acid-increase-risk-of-arterial-stiffness
#14
Piyanuch Thitiwuthikiat, Duangduan Siriwittayawan, Teonchit Nuamchit
Prehypertension and serum uric acid are emerging as independent risk factors for arterial stiffness and may also predict cardiovascular diseases. Previous studies have demonstrated the association between serum uric acid and arterial stiffness in hypertensive adults, but there are limited studies in prehypertensive adults. We compared the serum uric acid (SUA) and cardio-ankle vascular index (CAVI) between normotensive and prehypertensive participants. The association between SUA, prehypertension and CAVI were investigated...
November 6, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/29082115/using-mendelian-randomization-studies-to-assess-causality-and-identify-new-therapeutic-targets-in-cardiovascular-medicine
#15
Wei Zhao, Jung-Jin Lee, Asif Rasheed, Danish Saleheen
Integration of knowledge generated from genetic studies on intermediate biomarkers and CHD can provide a reliable approach to help assess causal pathways in coronary heart disease. Mendelian Randomization (MR) studies are a powerful tool to assess causal relevance of a range of pathways. These analyses use genetic variants as proxies for soluble biomarkers in association studies of disease risk. MR studies can provide unbiased estimates of causal effects and avoid distortions due to confounding factors arising later in life, because genetic variants are fixed at conception...
December 2016: Current Genetic Medicine Reports
https://www.readbyqxmd.com/read/29077696/hyperuricemia-on-admission-predicts-short-term-mortality-due-to-myocardial-infarction-in-a-population-with-high-prevalence-of-cardiovascular-risk-factors
#16
Mauricio Mora-Ramírez, Irving O Estevez-Garcia, María E Irigoyen-Camacho, Rafael Bojalil, Héctor Gonzalez-Pacheco, Luis M Amezcua-Guerra
BACKGROUND: National health surveys have revealed an outstandingly high prevalence of obesity, hypertension, and diabetes in Mexico. OBJECTIVE: To assess whether serum uric acid levels on admission may predict short-term mortality in patients with ST-segment elevation myocardial infarction in a population with an unusually high prevalence of classic cardiovascular risks. METHODS: A total of 795 ST-segment elevation myocardial infarction patients undergoing primary reperfusion therapy were classified as having normouricemia or hyperuricemia according to serum uric acid levels at admission, and the occurrence of mortality and major adverse cardiovascular events during coronary care unit stay was assessed...
September 2017: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/29073236/prevalence-of-peripheral-artery-disease-pad-and-factors-associated-an-epidemiological-analysis-from-the-population-based-screening-pre-diabetes-and-type-2-diabetes-spredia-2-study
#17
V Cornejo Del Río, J Mostaza, C Lahoz, V Sánchez-Arroyo, C Sabín, S López, P Patrón, P Fernández-García, B Fernández-Puntero, D Vicent, L Montesano-Sánchez, F García-Iglesias, T González-Alegre, E Estirado, F Laguna, C de Burgos-Lunar, P Gómez-Campelo, J C Abanades-Herranz, J M de Miguel-Yanes, M A Salinero-Fort
AIM: To describe the prevalence of Peripheral Artery Disease (PAD) in a random population sample and to evaluate its relationship with Mediterranean diet and with other potential cardiovascular risk factors such as serum uric acid and pulse pressure in individuals ranged 45 to 74 years. METHODS: Cross-sectional analysis of 1568 subjects (mean age 6.5 years, 43% males), randomly selected from the population. A fasting blood sample was obtained to determine glucose, lipids, and HbA1C levels...
2017: PloS One
https://www.readbyqxmd.com/read/28984255/risk-factors-for-cardiovascular-disease-in-obese-children
#18
T Chandrasekhar, M M Suchitra, M Pallavi, P V L N Srinivasa Rao, Alok Sachan
OBJECTIVE: To study the prevalence of cardiovascular risk factors in pediatric obesity. METHODS: 50 obese children (age 5-17y) and 50 apparently healthy non-obese children (body mass index of over 95th percentile and between 5th to 95th percentiles, respectively) using Centre for Disease Control growth charts were included. Fasting blood sugar, lipid profile, insulin, homeostasis model assessment of insulin resistance, uric acid, fibrinogen, lipoprotein (a), homocysteine, malondialdehyde, ferric reducing ability of plasma and nitric oxide were measured...
September 15, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/28952391/the-problem-of-cardio-renal-diseases-in-patients-with-gout
#19
Claudio Ferri
BACKGROUNDS: Although evidence is mounting on the role of hyperuricemia in cardio-renal disease, continuing doubt remains as to whether hyperuricemia can be considered a major causal cardiovascular risk factor. In addition, available data suggest that treatment may be beneficial, even in the absence of overt gout, when hyperuricemia accompanies other clinical conditions, such as urate deposition, advanced chronic kidney disease, or cardiovascular risk factors. METHODS AND RESULTS: Analysis of the literature suggests there would be sufficient evidence warranting clinical trials to determine whether lowering uric acid levels would be clinically beneficial in the prevention or treatment of cardiovascular and renal diseases...
November 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28952389/effects-of-serum-uric-acid-on-blood-pressure-lowering-treatment
#20
Guido Grassi
If hyperuricemia is an independent risk factor in blood-pressure control, urate-lowering therapy should be used to reduce cardiovascular risk. It may also act as a prognostic marker of other abnormalities. This review presents current evidence on the relationship between hyperuricemia and hypertension.
November 2017: Current Medical Research and Opinion
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