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Rong Mu, Jun Liang, Lingyun Sun, Zhuoli Zhang, Xiangyuan Liu, Cibo Huang, Ping Zhu, Xiaoxia Zuo, Jieruo Gu, Xiangpei Li, Xingfu Li, Yi Liu, Ping Feng, Zhanguo Li
AIM: To investigate the efficacy and safety of technetium-99 conjugated with methylene diphosphonate (99 Tc-MDP, Yunke Pharmaceutical industry) in the treatment of rheumatoid arthritis (RA). METHODS: A total of 120 patients with active RA were randomly divided into three groups: Group A (receiving oral meloxicam tablets); Group B (receiving intravenous drip of 99 TC-MDP); Group C (receiving combination treatment of intravenous drip of 99 Tc-MDP and oral meloxicam tablets)...
January 2018: International Journal of Rheumatic Diseases
Katie Stromsland, Laura M Zimmerman
Reptilian immune systems are believed to rely more heavily on the innate response than the adaptive response. Past research on reptilian immune systems has indicated that natural antibodies (NAbs) play an important role in fighting antigens as the first responder and initiating the innate immune response. However, there is a gap in research on NAbs in reptiles as there is little data on how they may influence parasite prevalence in reptiles. Furthermore, no studies have examined NAbs at mucosal sites, which represent an important point of entry for parasites...
July 2017: Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology
Ling Pan, Yi-Long Xi, Jing Gu, Shan Jiang, Han Zhu, Bing-Xing Zhang
Predation plays an important role in mediating the coexistence and the community structure of rotifera. In response to predation stresses, prey rotifers develop morphological defenses and change their life-history strategy for the reallocation of energy investment. Yet, how these changes respond to different total energy ingestion remains largely unknown. In the present study, we investigated the life-table demographic, population growth and morphological parameters of Brachionus calyciflorus in response to various densities of Asplanchna sieboldi at two food levels (1...
October 2017: Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology
Yoshiaki Matsumoto, Junji Itou, Fumiaki Sato, Masakazu Toi
Understanding the mechanism by which cancer cells enhance stemness facilitates cancer therapies. Here, we revealed that a stem cell transcription factor, SALL4, functions to enhance stemness in basal-like breast cancer cells. We used shRNA-mediated knockdown and gene overexpression systems to analyze gene functions. To evaluate stemness, we performed a sphere formation assay. In SALL4 knockdown cells, the sphere formation ability was reduced, indicating that SALL4 enhances stemness. CD44 is a membrane protein and is known as a stemness factor in cancer...
January 22, 2018: Cancer Medicine
Giuseppe Celenza, Mattia Vicario, Pierangelo Bellio, Linciano Pasquale, Mariagrazia Perilli, Antonio Oliver, Jesus Blazquez, Laura Cendron, Donatella Tondi
The emergence and dissemination of multi drug resistant (MDR) pathogens resistant to near all available antibiotics poses a significant threat in clinical therapy. Among them, Klebsiella pneumoniae clinical isolates overexpressing KPC-2 carbapenemase are the most worrisome, extending bacterial resistance to last resort carbapenems. In this study we investigate the molecular recognition requirements in KPC-2 active site by small phenyl boronic acid derivatives. Four new phenyl boronic acid derivatives were designed and tested vs KPC-2...
January 22, 2018: ChemMedChem
Tomas Homola, Jan Pospišil, Richard Krumpolec, Pavel Souček, Petr Dzik, Martin Weiter, Mirko Černák
This contribution presents a low-temperature method for dry hydrogen plasma reduction of inkjet-printed flexible graphene oxide (GO) electrodes, an approach compatible with processes envisaged for the manufacture of flexible electronics. The processing of GO to reduced graphene oxide (rGO) was performed in 1-64 seconds, and sp2/sp2+sp3 carbon concentration increased from approx. 20% to 90%. Since the plasma reduction was associated with an etching effect, the optimal reduction time occurred between 8 and 16 seconds...
January 22, 2018: ChemSusChem
Xin Yin, Baohong Zou, Xuexue Hong, Mingjun Gao, Weibing Yang, Xiangbin Zhong, Yang He, Peng Kuai, Yonggen Lou, Jirong Huang, Jian Hua, Zuhua He
Breeding for disease resistance is the most effective strategy to control diseases, particularly with broad-spectrum disease resistance in many crops. However, knowledge on genes and mechanism of broad-spectrum resistance and tradeoff between defense and growth in crops is limited. Here, we show that the rice copine genes OsBON1 and OsBON3 are critical suppressors of immunity. Both OsBON1 and OsBON3 changed their protein subcellular localization upon pathogen challenge. Knockdown of OsBON1 and dominant negative mutant of OsBON3 enhanced resistance to rice bacterial and fungal pathogens with either hemibiotrophic or necrotrophic life styles...
January 22, 2018: Plant Biotechnology Journal
Weilu Cheng, Zhongyang Zhang, Ruodan Xu, Panpan Cai, Peter Kristensen, Menglin Chen, Yudong Huang
Effective and affordable, antibacterial and hemostatic materials are of great interests in clinical wound care practices. Herein, Enterobacteria phage T4 were incorporated in polycaprolactone/collagen I (PCL-ColI) nanofibers via electrospinning in order to eradicate Escherichia coli infection and meanwhile establish hemostasis. Tensile strength of the membrane was significantly enhanced with increased PCL ratio. Those with a collagen component above 70% were demonstrated to be more hemostatic with shorter hemostatic time and smaller amount of bleeding...
January 22, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Erin E Mowers, Marina N Sharifi, Kay F MacLeod
Macro-autophagy is an ancient and highly-conserved self-degradative process that plays a homeostatic role in normal cells by eliminating organelles, pathogens and protein aggregates. Autophagy, as it is routinely referred to, also allows cells to maintain metabolic sufficiency and survive under conditions of nutrient stress by recycling the by-products of autophagic degradation, such as fatty acids, amino acids and nucleotides. Tumor cells are more reliant than normal cells on autophagy for survival in part due to their rapid growth rate, altered metabolism and nutrient deprived growth environment...
January 21, 2018: FEBS Journal
David Medina Cruz, Gujie Mi, Thomas J Webster
Antimicrobial resistance is a global concern that affects more than 2 million people each year. Therefore, new approaches to kill bacteria are needed. One of the most promising methodologies may come from metallic nanoparticles, since bacteria may not develop a resistance to these nanostructures as they do for antibiotics. While metallic nanoparticle synthesis methods have been well studied, they are often accompanied by significant drawbacks such as cost, extreme processing conditions and toxic waste production since they use harsh chemicals such as corrosive agents (hydrazine) or strong acids (hydrochloride acid)...
January 22, 2018: Journal of Biomedical Materials Research. Part A
V E Bianchi, V Locatelli
Metabolic syndrome (MetS) is highly correlated with cardiovascular diseases. Although an excess of body fat is a determinant factor for MetS development, a reduced level of testosterone plays a fundamental role in its regulation. Low testosterone level is highly related to insulin resistance, visceral obesity and MetS. We have searched in Pubmed clinical trial with the password: testosterone and insulin resistance, and testosterone and MetS. We found 19 studies on the correlation between testosterone level with insulin resistance and 18 on the effect of testosterone therapy on MetS...
January 21, 2018: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
Maíra Duarte Cardoso, Leila Soledade Lemos, Emily Moraes Roges, Jailson Fulgencio de Moura, Davi Castro Tavares, Carlos Alexandre R Matias, Dália Dos Prazeres Rodrigues, Salvatore Siciliano
AIMS: To perform a microbiological survey regarding the presence, prevalence and characterization of Aeromonas sp. and Vibrio sp. in debilitated wrecked marine birds recovered from the center-north coast of the state of Rio de Janeiro, Brazil. METHODS AND RESULTS: Swabs obtained from 116 alive and debilitated wrecked marine birds, comprising 19 species, from the study area were evaluated by biochemical methods. Antimicrobial susceptibility tests and pathogenicity gene screening were performed for bacterial strains of public health importance...
January 21, 2018: Journal of Applied Microbiology
Bao-Lam Huynh, Jeffrey D Ehlers, Bevan Emma Huang, Maria Munoz-Amatriain, Stefano Lonardi, Jansen R P Santos, Arsenio Ndeve, Benoit J Batieno, Ousmane Boukar, Ndiaga Cisse, Issa Drabo, Christian Fatokun, Francis Kusi, Richard Y Agyare, Yi-Ning Guo, Ira Herniter, Sassoum Lo, Steve I Wanamaker, Shizhong Xu, Timothy J Close, Philip A Roberts
Multi-parent Advanced Generation Inter-Cross (MAGIC) populations are an emerging type of resource to dissect the genetic structure of traits and improve breeding populations. We developed a MAGIC population for cowpea (Vigna unguiculata L. Walp.) from eight founder parents which are genetically diverse and carry many abiotic and biotic stress resistance, seed quality and agronomic traits relevant to cowpea improvement in the USA and sub-Saharan Africa, where cowpea is vitally important in the human diet and local economies...
January 21, 2018: Plant Journal: for Cell and Molecular Biology
Muhammad Akram, Imtiaz Mahmood Tahir, Syed Muhammad Ali Shah, Zahed Mahmood, Awais Altaf, Khalil Ahmad, Naveed Munir, Muhammad Daniyal, Suhaila Nasir, Huma Mehboob
Viral infections are being managed therapeutically through available antiviral regimens with unsatisfactory clinical outcomes. The refractory viral infections resistant to available antiviral drugs are alarming threats and a serious health concern. For viral hepatitis, the interferon and vaccine therapies solely are not ultimate solutions due to recurrence of hepatitis C virus. Owing to the growing incidences of viral infections and especially of resistant viral strains, the available therapeutic modalities need to be improved, complemented with the discovery of novel antiviral agents to combat refractory viral infections...
January 22, 2018: Phytotherapy Research: PTR
Neil Burford, Christopher Frazee, Robert McDonald, Michael Ferguson, Brian Patrick, Andreas Decken
Reaction of Ph2SbCl3 with 2,2'-bipyridine and Me3SiOSO2CF3 releases chlorobenzene, which is interpreted as a reductive (SbV/SbIII) elimination from a cationic complex of a stiboranium cation. Conversely, reactions of Ph2SbCl3 with 4-methylpyridine-N-oxide and AgOSO2CF3 give redox resistant complexes with the generic formulae [Ph2SbCl3-xLx+1][OTf]x, including a compound containing the first example of a pnictogen(V) trication.
January 22, 2018: Chemistry: a European Journal
Alexandra M Webster, Steven Lorimer Cobb
Over the past two decades, developing medical applications for peptides has, and continues to be a highly active area of research. At present there are over 60 peptide-based drugs on the market and more than 140 in various stages of clinical trials. The interest in peptide-based therapeutics arises from their biocompatibility and their ability to form defined secondary and tertiary structures, resulting in a high selectivity for complex targets. However, there are significant challenges associated with the development of peptide-based therapeutics, namely peptides are readily metabolised in vivo...
January 22, 2018: Chemistry: a European Journal
Nutan Thakur, Swapnil Jain, Harish Changotra, Rahul Shrivastava, Yashwant Kumar, Neelam Grover, Jitendraa Vashistt
BACKGROUND: Diarrheagenic Escherichia coli (DEC) signifies as an important etiological agent of moderate-to-severe diarrhea. This study was primarily focused on molecular identification of DEC pathotypes; their association with serogroups and estimates of resistance profiles against different antibiotics regime. METHODS: Five hundred seventy-two stool specimens from diarrhea patients were investigated for DEC pathotypes. Molecular pathotypes were identified by amplification of virulence genes associated with distinct pathotypes followed by sequencing...
January 21, 2018: Journal of Clinical Laboratory Analysis
Xiaoyun Tan, Jing Zhang, Shaoyi Zhou, Zhenyin Liu, Tao Zhang, Jiejun Xia
Vascular tumors associated with Kasabach-Merritt phenomenon (KMP) are life-threatening and the mortality is as high as 10-30%. Steroids are considered the primary choice for drug therapy. However, there are many steroid-resistant cases. In the present study, analyzed data are presented to support the use of sirolimus in clinical practise for the treatment of corticosteroid-resistant vascular tumors with KMP in eight infants between June 2015 and April 2017 in a single hospital. The time to initial response was 6...
January 21, 2018: Journal of Dermatology
Xiaolei Wang, Heng Du, Shanshan Shao, Tao Bo, Chunxiao Yu, Wenbin Chen, Lifang Zhao, Qiu Li, Li Wang, Xiaojing Liu, Xiaohui Su, Mingqi Sun, Yongfeng Song, Ling Gao, Jiajun Zhao
Physiological opening of the mitochondrial permeability transition pore (mPTP) is indispensable for maintaining mitochondrial function and cell homeostasis, but the role of mPTP and its initial factor, cyclophilin D (CypD) in hepatic steatosis is unclear. Here, we demonstrated that excess mPTP opening mediated by the increase of CypD expression induced hepatic mitochondrial dysfunction. Notably, such mitochondrial perturbation occurred before detectable triglyceride (TG) accumulation in the liver of HFD-fed mice...
January 21, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
Lucia Visser, Igne Sinkeviciute, Iris E Sommer, Josef J Bless
Auditory verbal hallucinations complicate many psychiatric disorders. Antipsychotic medication is effective in the majority, but a significant minority experiences high burden from resistant hallucinations. Here, we aim to improve executive control, in an attempt to decrease burden from hallucinations. We describe the use of a cognitive trainings app by a young woman with highly resistant hallucinations. With modest training, a significant decrease in the duration of hallucinations was reached. Possibilities of this training technique are discussed...
February 2018: Scandinavian Journal of Psychology
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