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Cholesteatoma

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https://www.readbyqxmd.com/read/29651799/fatal-cervicomediastinal-necrotising-fasciitis-due-to-cholesteatoma
#1
Aaron K K Smith, Touch Sokdavy, James G Gollogly, Mahmood F Bhutta
No abstract text is available yet for this article.
April 12, 2018: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29649053/bilateral-congenital-cholesteatoma
#2
Chang Ho Lee, Mi Kyung Kim, Hyoung-Mi Kim, Cheongse Won, Tae Hyun Shin, So Young Kim
OBJECTIVE: To report the first large case series of extremely rare bilateral congenital cholesteatoma (CC). STUDY DESIGN: A retrospective cohort study. SETTING: University hospital otology referral clinic. PATIENTS: Six hundred four children with surgically confirmed CC. MAIN OUTCOME MEASURES: The bilateral CCs were compared with the unilateral CCs. RESULTS: The incidence of bilateral CC was 3...
April 11, 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29644162/clinical-study-on-middle-ear-diseases-in-children-with-orofacial-clefts
#3
Raja Kalaiarasi, Kamran A Syed, Chellappa Vijayakumar, Ajoy M Varghese, Mary John
Introduction Orofacial clefts are associated with middle ear diseases, but the magnitude of this problem is not generally well appreciated. The aim of this study was to describe the middle ear findings and audiological profile in children with orofacial clefts. Materials and methods Children with orofacial clefts attending plastic surgery and otorhinolaryngology departments of a tertiary hospital over one-year duration were included in this study. Ninety-six children with orofacial clefts were identified. They were categorized age-wise as zero to five years, more than five years to 10 years, and more than 10 years to 15 years...
February 8, 2018: Curēus
https://www.readbyqxmd.com/read/29619095/platelet-rich-plasma-in-reconstruction-of-posterior-meatal-wall-after-canal-wall-down-mastoidectomy
#4
Mohammad El-Sayed Abd Elbary, Wail Fayez Nasr, Samir Sorour Sorour
Introduction  Canal wall down (CWD) mastoidectomy has many drawbacks, including chronic otorrhea not responding to medications, granulations, dizziness on exposure to cold or hot water, and tendency of debris accumulation in the mastoid cavity, demanding periodic cleaning. Many of these problems can be solved by reconstruction of the posterior meatal wall (PMW). Objectives  To assess the results of PMW reconstruction after CWD mastoidectomy for cholesteatoma using titanium mesh and platelet-rich plasma (PRP) mixed with bone pate...
April 2018: International Archives of Otorhinolaryngology
https://www.readbyqxmd.com/read/29602456/are-human-atp-binding-cassette-transporter-c11-and-earwax-associated-with-the-incidence-of-cholesteatoma
#5
Hiroshi Nakagawa, Yu Toyoda, Tobias Albrecht, Megumi Tsukamoto, Mark Praetorius, Toshihisa Ishikawa, Kazusaku Kamiya, Takeshi Kusunoki, Katsuhisa Ikeda, Serkan Sertel
Cholesteatoma is an ear disease based on a locally destructive noncancerous conglomerate of epidermis and keratin debris. Abnormal growth of stratified keratinized squamous epithelium in the temporal bone causes destruction of the outer and middle ear, potentially leading to hearing impairment, facial palsy, vertigo, lateral sinus thrombosis, and intracranial complications. Although cholesteatoma is effectively treated by surgical resection (mastoidectomy), the lack of effective and nonsurgical therapies potentially results in fatal consequences, establishing the need for a comprehensive investigation of cholesteatoma pathogenesis...
May 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29599061/cholesteatoma-labyrinthine-fistula-prevalence-and-impact
#6
Letícia P Schmidt Rosito, Inesângela Canali, Adriane Teixeira, Mauricio Noschang Silva, Fábio Selaimen, Sady Selaimen da Costa
INTRODUCTION: Labyrinthine fistula is one of the most common complications associated with cholesteatoma. It represents an erosive loss of the endochondral bone overlying the labyrinth. Reasons for cholesteatoma-induced labyrinthine fistula are still poorly understood. OBJECTIVE: Evaluate patients with cholesteatoma, in order to identify possible risk factors or clinical findings associated with labyrinthine fistula. Secondary objectives were to determine the prevalence of labyrinthine fistula in the study cohort, to analyze the role of computed tomography and to describe the hearing results after surgery...
March 9, 2018: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/29595581/reconstruction-of-the-canal-wall-in-tympanoplasty-for-cholesteatoma-with-titanium-sheeting
#7
Bruce Black, Ian Gutteridge
No abstract text is available yet for this article.
March 27, 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29594077/results-of-type-i-tympanoplasty-using-fascia-with-or-without-cartilage-reinforcement-10-years-experience
#8
Ali Kouhi, Mohammad Taghi Khorsandi Ashthiani, Mir Mohammad Jalali
Introduction: There remains controversy about the optimal kind of graft to repair tympanic membrane. The purpose of this study was to evaluate the anatomical and auditory outcomes of type I tympanoplasty using fascia with or without cartilage reinforcement. Materials and Methods: This retrospective cohort study was conducted from 2005 to 2015. All cases were surgically treated by a single surgeon. We excluded cases in which the etiology of chronic otitis media was cholesteatoma...
March 2018: Iranian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/29565455/long-noncoding-rnas-show-differential-expression-profiles-and-display-cerna-potential-in-cholesteatoma-pathogenesis
#9
Juanjuan Gao, Qi Tang, Xiaohui Zhu, Shihua Wang, Yongli Zhang, Wenbin Liu, Zhiqiang Gao, Hua Yang
Cholesteatoma is a pathologically benign but clinically destructive middle ear disease, which is caused by excessive epidermal migration and uncontrolled hyperproliferation of keratinocytes of squamous epithelium, leading to various clinical manifestations and serious complications, such as hearing loss, dizziness, facial paralysis, meningitis, and hydrocephalus. However, the pathogenesis of cholesteatoma is still not fully understood. Herein, we performed microarray analysis to identify the differentially expressed patterns of lncRNAs in cholesteatoma for the first time...
May 2018: Oncology Reports
https://www.readbyqxmd.com/read/29559833/downregulation-of-mir-203a-disinhibits-bmi1-and-promotes-growth-and-proliferation-of-keratinocytes-in-cholesteatoma
#10
Jian Zang, Lian Hui, Ning Yang, Bo Yang, Xuejun Jiang
Background: Keratinocytes are the predominant cell type in a cholesteatoma, and microRNA (miR)-203a has been shown to be essential for the growth and differentiation of keratinocytes. The regulatory mechanisms of miR-203a and Bmi1-the predicted target of miR-203a that is associated with cholesteatoma-have not been clarified. Methods: Real-time PCR and western blot were carried out for the detection of miRNAs, mRNAs, and proteins, including miR-203a, Bmi1, and phosphorylated (p-)Akt. Immunohistochemical staining was applied to observe the expression and distribution of Bmi1 and of p-Akt in cholesteatoma and in control retroauricular skin...
2018: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29557844/response-to-the-prevention-of-recurrent-cholesteatoma-in-cwu-surgery
#11
Ronald Sahyouni, Omid Moshtaghi, Hossein Mahboubi, Harrison W Lin, Hamid Reza Djalilian
No abstract text is available yet for this article.
March 19, 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29549594/keratinocyte-growth-factor-kgf-modulates-epidermal-progenitor-cell-kinetics-through-activation-of-p63-in-middle-ear-cholesteatoma
#12
Tomomi Yamamoto-Fukuda, Naotaro Akiyama, Masahiro Takahashi, Hiromi Kojima
The basal stem/progenitor cell maintains homeostasis of the epidermis. Progressive disturbance of this homeostasis has been implicated as a possible cause in the pathogenesis of epithelial disease, such as middle ear cholesteatoma. In many cases of stem/progenitor cell regulation, the importance of extracellular signals provided by the surrounding cells is well-recognized. Keratinocyte growth factor (KGF) is a mesenchymal-cell-derived paracrine growth factor that specifically participates in skin homeostasis; however, the overexpression of KGF induces middle ear cholesteatoma...
March 16, 2018: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/29543959/single-stage-mastoid-obliteration-in-cholesteatoma-surgery-and-recurrent-and-residual-disease-rates-a-systematic-review
#13
Hylke F E van der Toom, Marc P van der Schroeff, Robert Jan Pauw
Importance: The ideal surgical treatment of cholesteatoma has been subject to discussion for years because both traditional surgical techniques (canal wall down [CWD] and canal wall up [CWU] tympanoplasty) have their own advantages and disadvantages. A more recently propagated surgical approach, to combine the CWD or CWU tympanoplasty technique with obliteration of the mastoid and epitympanum, is showing promising results. Objective: To systematically review the literature on recurrent and residual cholesteatoma rates after single-stage CWU and CWD tympanoplasty with mastoid obliteration...
March 15, 2018: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29533334/application-of-regenerative-treatment-for-tympanic-membrane-perforation-with-cholesteatoma-tumor-or-severe-calcification
#14
Shin-Ichi Kanemaru, Rie Kanai, Misaki Yoshida, Yuji Kitada, Kaoru Omae, Shigeru Hirano
OBJECTIVE: To apply regenerative treatment for tympanic membrane (TM) perforation to patients with severe calcification of the TM, cholesteatomas, or tumors localized to the tympanic cavity. STUDY DESIGN: Controlled clinical pilot study. SETTING: General hospitals. PATIENTS: Forty-five patients (age: 8-85; M = 19, F = 26) were selected from patients with or without TM perforation for the regenerative treatment...
April 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29532311/intraparenchymal-epidermoid-cyst-proper-surgical-management-may-lead-to-satisfactory-outcome
#15
Jian Zheng, Chun Wang, Fengqiang Liu
Intraparenchymal epidermoid cysts (IECs) are rare lesions, thus the preoperative diagnosis and proper surgical management are still a challenge. We searched the database at our institution and performed a search of English literature in PubMed and Google Scholar. Keywords used were as follows: "intraparenchymal"; "intracerebral"; "intraaxial"; "epidermoid cyst"; "brainstem"; "cholesteatoma"; "pearly tumor". Only cases that were true intraparenchymally located and contained adequate clinical information were included...
March 12, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29526381/bioglass-reconstruction-of-posterior-meatal-wall-after-canal-wall-down-mastoidectomy
#16
Samir Sorour Sorour, Nasser Nagieb Mohamed, Magdy M Abdel Fattah, Mohammad El-Sayed Abd Elbary, Mohammad Waheed El-Anwar
BACKGROUND: Canal wall down (CWD) mastoidectomy has many drawbacks including chronic otorrhea, granulations, dizziness on exposure to cold or hot water and tendency of debris accumulation in the mastoid cavity demanding periodic cleaning. Many of these problems can be solved by reconstruction of the posterior meatal wall (PMW). OBJECTIVES: To assess the results of PMW reconstruction after CWD mastoidectomy for cholesteatoma using bioactive glass (BAG) that is fabricated and built up intraoperatively...
March 6, 2018: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29519185/canal-wall-down-procedure-with-soft-posterior-meatal-wall-reconstruction-in-acquired-cholesteatoma-focus-on-postoperative-middle-ear-status
#17
Tomoyasu Tachibana, Shin Kariya, Yorihisa Orita, Michihiro Nakada, Takuma Makino, Yasutoshi Komatsubara, Yuko Matsuyama, Yuto Naoi, Kazunori Nishizaki
OBJECTIVES: We reviewed surgical results of canal wall-down tympanoplasty (CWDT) with soft posterior meatal wall reconstruction (SWR) for acquired cholesteatoma (AC), and identified factors associated with surgical outcomes. METHODS: Results from 119 ears with AC (pars flaccida, n = 99; pars tensa, n = 20) that underwent CWDT with SWR were retrospectively reviewed. We defined postoperative balloon-like retraction (PBR) with web formation, which needed reoperation to clean accumulated cerumen, as postoperative deep retraction pocket (PDRP)...
March 8, 2018: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29517472/curved-adjustable-fibre-optic-diode-laser-in-microscopic-cholesteatoma-surgery-description-of-use-and-review-of-the-relevant-literature
#18
C J McCaffer, L Pabla, C Watson
OBJECTIVE: The use of lasers in cholesteatoma surgery is common and well accepted. The most commonly used laser fibres are straight and non-adjustable; these have several limitations. This paper describes the use of an alternative laser fibre. METHOD: This 'How I Do It' paper describes and illustrates the use of an alternative curved adjustable fibre-optic diode laser in microscopic cholesteatoma surgery. RESULTS: The curved, adjustable laser fibre allows accurate and atraumatic disease removal when the use of a straight laser fibre may be less effective or accurate...
March 8, 2018: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/29516060/endoscopic-transcanal-modified-canal-wall-down-mastoidectomy-for-cholesteatoma
#19
Hamed Sajjadi
Attic cholesteatoma with antral extension in tight sclerotic mastoid cavities is a common presentation that creates difficult decision-making intraoperatively. Drilling through a sclerotic and small mastoid cavity, keeping the canal wall intactis often difficult and increases the risk of serious injury. Consequently, a canal-wall-down mastoidectomy is often performed. The endoscopic transcanal modified canal-wall-down mastoidectomy approach allows the benefits of an open cavity for cholesteatoma resection and the benefits of a closed cavity for better long-term care and a more normal ear canal and middle ear reconstruction...
September 2017: World journal of otorhinolaryngology—head and neck surgery
https://www.readbyqxmd.com/read/29516058/use-of-porcine-small-intestinal-submucosa-for-pediatric-endoscopic-tympanic-membrane-repair
#20
REVIEW
Razan A Basonbul, Michael S Cohen
Tympanic membrane perforationsoccur frequently in children, and can result in hearing loss, otorrhea, pain, and cholesteatoma. Due to the narrower ear canal in children, a postauricular incision is often needed to access the tympanic membrane for surgical repair. Endoscopic approaches are increasingly being used for tympanic membrane repair, reducing the need for postauricular incisions. As the need for a postauricular incision decreases, the demand for non-autologous grafting material has increased. Acellular porcine small intestinal submucosa (SIS) has been described in the literature as an alternative to commonly used autologous grafts, and is well suited for use with transcanal endoscopic ear surgery as a minimally invasive approach...
September 2017: World Journal of Otorhinolaryngology—Head and Neck Surgery
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