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Cholesteatoma

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https://www.readbyqxmd.com/read/28325168/impact-of-pharyngofixation-in-cleft-palate-repair-surgery-on-the-development-of-chronic-adhesive-otitis-media
#1
L Otruba, P Schalek, Z Hornáčková
BACKGROUND: A significant percentage of children with cleft palate suffer from otitis media with effusion and its consequences, such as deafness, chronic adhesive otitis and cholesteatoma. This study aimed to determine whether these effects can be minimised by selecting pharyngofixation as the surgical technique for cleft palate correction. METHODS: A retrospective study was performed of 155 patients (308 ears) who underwent surgery from age 5 months to 8 years and were followed up for 36-84 months...
March 22, 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28303055/inner-ear-disturbances-related-to-middle-ear-inflammation
#2
REVIEW
Michihiko Sone
The inner and middle ear are connected mainly through round and oval windows, and inflammation in the middle ear cavity can spread into the inner ear, which might induce a disturbance. In cases with intractable otitis media, attention should also be paid to symptoms related to the inner ear. In this paper, middle ear inflammation and related inner ear disturbances are reviewed with a focus on representative middle ear diseases (such as acute otitis media, chronic otitis media, otitis media with anti-neutrophil cytoplasmic antibody-associated vasculitis, eosinophilic otitis media, cholesteatoma with labyrinthine fistula, and reflux-related otitis media)...
February 2017: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/28288478/benign-temporomandibular-joint-lesions-presenting-as-masses-in-the-external-auditory-canal
#3
Ryan A Williams, Robert K Jackler, C Eduardo Corrales
OBJECTIVE: Describe benign lesions arising from the temporomandibular joint (TMJ) that presented as masses in the external auditory canal (EAC). STUDY DESIGN: Retrospective case series of two academic medical centers. PATIENTS: Six patients with lesions emanating from the TMJ that presented as EAC masses. Lesions included pigmented villonodular synovitis (PVNS), nodular fasciitis, foramen of Huschke herniation with salivary fistula, fibroepithelial polyp, superficial angiomyxoma, and giant cell tumor (GCT)...
April 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28288477/intraoperative-bleeding-and-the-risk-of-residual-cholesteatoma-a-multivariate-analysis
#4
Gavin J le Nobel, Sharon L Cushing, Blake C Papsin, Adrian L James
OBJECTIVE: Residual cholesteatoma most frequently occurs where visualization and surgical access are restricted by anatomic constraints. Other factors that compromise surgical field visualization might also increase rates of residual cholesteatoma. We evaluated whether impaired surgical field clarity from bleeding increases rates of residual cholesteatoma. STUDY DESIGN: Prospective cohort study. SETTING: Tertiary care hospital. PATIENTS: Consecutive series of children having intact canal wall surgery for cholesteatoma...
April 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28288476/the-role-of-rho-rho-kinase-pathway-in-the-pathogenesis-of-cholesteatoma
#5
Mesut Yeşilova, Kemal Görür, Onur Ismi, Cengiz Özcan, Kansu Büyükafşar
OBJECTIVE: To assess the role of Rho/Rho-kinase pathway in the pathogenesis of cholesteatoma. MATERIALS AND METHODS: Thirty-eight patients with cholesteatoma, who had gone mastoidectomies were enrolled in this prospective study. Cholesteatomas matrix (CM) and a piece of the external ear canal skin (EECS as control) were taken and transferred to the liquid nitrogen and kept at -86 °C for Rho A and Rho-kinase (ROCK) analysis with Western blotting and commercial ELISA kits (Cell Biolabs Inc...
April 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28286870/d-amino-acids-do-not-inhibit-pseudomonas-aeruginosa-biofilm-formation
#6
Wee Tin K Kao, Mitchell Frye, Patricia Gagnon, Joseph P Vogel, Richard Chole
OBJECTIVE: Pseudomonas aeruginosa, a known biofilm-forming organism, is an opportunistic pathogen that plays an important role in chronic otitis media, tracheitis, cholesteatoma, chronic wounds, and implant infections. Eradication of biofilm infections has been a challenge because the biofilm phenotype provides bacteria with a protective environment from the immune system and antibiotics; thus, there has been great interest in adjunctive molecules that may inhibit biofilm formation or cause biofilm dispersal...
February 2017: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/28277483/endoscopy-assisted-ear-surgery-for-treatment-of-chronic-otitis-media-with-cholesteatoma-adhesion-or-retraction-pockets
#7
Cagatay Han Ulku
The objective of this study was to analyze the results of endoscopy-assisted ear surgery for the treatment of chronic otitis media with cholesteatoma, adhesion, or retraction pockets.Fifty-one patients who underwent oto-endoscopy-assisted canal wall up tympanomastoid surgery and/or limited anterior atticotomy with tympanoplasty for chronic otitis media with cholesteatoma, adhesion, or retraction pocket from 2006 to 2013 have been included in this study. Eradication of the disease from the middle ear and mastoid air cells was achieved by combination of the oto-microscobic and oto-endoscopic approaches...
March 8, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28274903/cholesteatoma-definition-and-classification-a-literature-review
#8
Justyna Rutkowska, Nuri Özgirgin, Ewa Olszewska
Cholesteatoma is a serious otolaryngologic condition that to date remains an important problem and poses a challenge to otolaryngologists around the world. To improve the approach pertaining to the diagnosis and management of middle ear cholesteatoma, clear, clinically applicable, and useful definition and classification of cholesteatoma are required. This review aimed to evaluate the current and most accepted descriptions and opinions concerning cholesteatoma. A review of the literature concerning different definitions and classifications of cholesteatoma was used in the preparation of the Cholesteatoma Guidelines, a project implemented by the European Academy of Otology - Neuro-otology...
March 9, 2017: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/28274897/surgical-treatment-of-external-auditory-canal-cholesteatoma-ten-years-of-clinical-experience
#9
Kuen Yao Ho, Tzu Yen Huang, Shih Meng Tsai, Hsun Mo Wang, Chen Yu Chien, Ning Chia Chang
OBJECTIVE: To describe the clinical manifestations of external auditory canal (EAC) cholesteatoma and evaluate the surgical outcomes of reconstruction using an inferior pedicled soft-tissue periosteum flap. MATERIALS AND METHODS: A total of 28 patients were enrolled in this retrospective study conducted at Kaohsiung Medical University Hospital in Taiwan between January 2004 and December 2013. EAC cholesteatoma was classified according to the disease extent. The surgery was performed to reconstruct a smooth contour of EAC...
March 9, 2017: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/28274504/practicality-analysis-of-the-staging-system-proposed-by-the-japan-otological-society-for-acquired-middle-ear-cholesteatoma-a-multicenter-study-of-446-surgical-cases-in-japan
#10
Keiji Matsuda, Tetsuya Tono, Hiromi Kojima, Yutaka Yamamoto, Masafumi Sakagami, Yasuo Mishiro, Yasuyuki Hinohira, Taeko Okuno
OBJECTIVE: The Objective of this study was to assess the practicality of the cholesteatoma staging system proposed by the Japan Otological Society (JOS) for acquired middle ear cholesteatoma (the 2010 JOS staging system). METHODS: Between 2009 and 2010, 446 ears with retraction pocket cholesteatoma underwent primary surgery at 6 institutions in Japan. The extent of cholesteatoma was surgically confirmed, and classified into three stages. RESULTS: The cholesteatoma affected the pars flaccida in 325 ears (73%), the pars tensa in 100 ears (22%), and both regions combined in 21 ears (5%)...
March 5, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28252594/-cholesteatoma-of-the-external-auditory-meatus
#11
K V Eremeeva, V M Svistushkin, V E Dobrotin, Zh T Godzhyan
This article was designed to present a concise overview of the literature concerning cholesteatoma of the external auditory meatus and to report the original clinical observation of this condition with special reference to the necessity of its early diagnostics and surgical treatment with the use of the combination of simultaneous sanation and reconstruction.
2017: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/28247225/update-from-the-4th-edition-of-the-world-health-organization-classification-of-head-and-neck-tumours-tumours-of-the-ear
#12
Lester D R Thompson
The 2017 fourth edition of the World Health Organization Classification of Tumours, specifically as it relates to the ear (Chap. 9), has several changes. Importantly, the number of entities has been significantly reduced by omitting tumors or lesions if they do not occur exclusively or predominantly at this site or if they are discussed in detail elsewhere in the book. These entities include: embryonal rhabdomyosarcoma, osteoma, exostosis, angiolymphoid hyperplasia with eosinophilia, Schneiderian papilloma, inverted papilloma, lipoma of the internal auditory canal, hemangioma, hematolymphoid tumors, and secondary tumors...
March 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28244845/incidence-10-year-recidivism-rate-and-prognostic-factors-for-cholesteatoma
#13
A Britze, M L Møller, T Ovesen
OBJECTIVE: Cholesteatoma patients have a high risk of recurrence with complications, and knowledge exchange is a prerequisite for improving treatment. This study aimed to apply appropriate statistics to provide meaningful and transferable results from cholesteatoma surgery, to highlight independent prognostic factors, and to assess the incidence rate. METHODS: Incidence rates were assessed for the district of Aarhus, Denmark. From 147 patients operated on mainly with canal wall up mastoidectomies for debuting cholesteatomas, 10-year Kaplan-Meier recidivism rates were calculated and independent prognostic factors for the recidivism were identified by Cox multivariate regression analyses...
April 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28243781/the-variants-of-the-retro-and-hypotympanum-an-endoscopic-anatomical-study
#14
Marco Bonali, Lukas Anschuetz, Matteo Fermi, Domenico Villari, Giulia Adalgisa Mariani, Lucia Manzoli, Marco Caversaccio, Livio Presutti
The retro- and hypotympanum are hidden areas of the middle ear, only poorly recognized. Nevertheless, this region is of relevant clinical significance, since it is regularly affected by disease such as cholesteatoma. The aim of this study is to explore and describe the anatomical variants of the hypo- and retrotympanum by the means of transcanal endoscopy. We hypothesize a significant variability of this hidden region of the middle ear. Moreover, we believe that the minimal invasive, endoscopic access is suitable since angled scopes may be used to explore the region...
February 27, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28239591/role-of-ct-mastoids-in-the-diagnosis-and-surgical-management-of-chronic-inflammatory-ear-diseases
#15
Juveria Majeed, L Sudarshan Reddy
Chronic Suppurative Otitis Media (CSOM) is a chronic inflammation of middle ear cleft. It presents with discharging ear and decreased hearing. The diagnosis is mostly on clinical examination with otoscope or oto endoscope. Computerised Tomography (CT) of mastoids is done to evaluate the extent of the disease and its complication. High resolution CT is now the investigation of choice for temporal bone disease. This study emphasizes on the importance of CT scan in diagnosis of inflammatory ear diseases and most importantly identifying pitfalls or complications which a surgeon can come across during surgery...
March 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/28236847/is-von-willebrand-disease-linked-to-cholesteatoma-aetiology
#16
 Reis Rego, M Santos, M Coutinho, T Feliciano, C Almeida E Sousa
Cholesteatoma is a common clinical picture seen by otolaryngologists. The disease is characterised by an abnormal grow "of skin in the wrong place". Specifically, in acquired cholesteatoma, the main causative issue is associated with ventilatory deficits within the middle ear and results in chronic infection. Molecular science has associated the presence of specific molecules with its development, and moreover recent research suggests that deregulated angiogenesis is a crucial process in the development of cholesteatoma and its recurrence...
March 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28225318/endoscopic-tympanoplasty-in-the-treatment-of-chronic-otitis-media-our-experience
#17
Giuseppe Panetti, Matteo Cavaliere, Maria Panetti, Anna Marino, Maurizio Iemma
CONCLUSION: The endoscopy ensures good surgical exposure of hidden areas, frequently sites of residual cholesteatoma. Also, the minimally invasive endoscopic approach is more respectful of anatomy and functionality of the middle ear, restoring and preserving mastoid mucosa, with faster healing time. OBJECTIVES: To investigate the benefits that the systematic use of endoscopy in middle ear surgery has made. STUDY DESIGN: Retrospective cohort studies...
March 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28224282/micrornas-effective-elements-in-ear-related-diseases-and-hearing-loss
#18
REVIEW
Mohammad-Reza Mahmoudian-Sani, Ameneh Mehri-Ghahfarrokhi, Fereshteh Ahmadinejad, Morteza Hashemzadeh-Chaleshtori, Massoud Saidijam, Mohammad-Saeid Jami
miRNAs are important factors for post-transcriptional process that controls gene expression at mRNA level. Various biological processes, including growth and differentiation, are regulated by miRNAs. miRNAs have been demonstrated to play an essential role in development and progression of hearing loss. Nowadays, miRNAs are known as critical factors involved in different physiological, biological, and pathological processes, such as gene expression, progressive sensorineural hearing loss, age-related hearing loss, noise-induced hearing loss, cholesteatoma, schwannomas, and inner ear inflammation...
February 21, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28219164/-a-combination-use-of-endoscope-and-microscope-in-cerebral-pontine-angle-surgery
#19
Z Y Wang, H Jia, J Yang, H Y Tan, H Wu
Objective: To evaluate the application of combination use of microscope and endoscope in cerebral pontine angle (CPA) surgery. Methods: A total of 72 patients undergone lateral skull base surgeries via endoscope under microscopic control from January 2006 to January 2015 was reviewed respectively. The patients including 35 males and 37 females were composed of 22 cases of vestibular swannnomas, 45 cases of cranial neuropathy and 5 cases of CPA chelesteatoma. Twenty cases of vestibular swannnomas, 15 cases of cranial neuropathy and 2 cases of CPA chelesteatoma undergone the surgery via retrosigmoid approach, while other cases undergone the surgery via retrolabyrinthine approach...
February 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/28218014/bilateral-otoneurological-pathology-to-operate-or-not
#20
Shivun Khosla, Matthew Elliot, Neil Donnelly
OBJECTIVE: To illustrate our experience when managing a complex patient with potentially life-threatening bilateral otological disease facing multisensory compromise including complete loss of audiovestibular function and visual disturbance Clinical presentation: A 67 year old lady, presented with a large left vestibular schwannoma and extensive right cholesteatoma encircling the otic capsule. She underwent translabyrinthine resection of the vestibular schwannoma, resulting in profound sensorineural hearing loss, vestibular hypofunction and corneal scarring following an initial temporary facial palsy...
March 2017: Cochlear Implants International
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