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Cholesteatoma

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https://www.readbyqxmd.com/read/28073243/cytokeratin-13-cytokeratin-17-and-ki-67-expression-in-human-acquired-cholesteatoma-and-their-correlation-with-its-destructive-capacity
#1
Mahmood A Hamed, Seiichi Nakata, Kazuya Shiogama, Kenji Suzuki, Ramadan H Sayed, Yoichi Nishimura, Noboru Iwata, Kouhei Sakurai, Badawy S Badawy, Ken-Ichi Inada, Hayato Tsuge, Yutaka Tsutsumi
Objectives: Cholesteatoma is a nonneoplastic destructive lesion of the temporal bone with debated pathogenesis and bone resorptive mechanism. Both molecular and cellular events chiefly master its activity. Continued research is necessary to clarify factors related to its aggressiveness. We aimed to investigate the expression of Ki-67, cytokeratin 13 (CK13) and cytokeratin 17 (CK17) in acquired nonrecurrent human cholesteatoma and correlate them with its bone destructive capacity. Methods: A prospective quantitative immunohistochemical study was carried out using fresh acquired cholesteatoma tissues (n=19), collected during cholesteatoma surgery...
January 12, 2017: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/28071070/surgery-for-cholesteatomatous-labyrinthine-fistula
#2
John Lim, Anupriya Gangal, Michael Brian Gluth
OBJECTIVE: There is uncertainty regarding the ideal surgical management of cholesteatomatous labyrinthine fistulae. The objective was to review the published evidence to determine whether a difference exists in hearing outcome for cholesteatoma matrix removal or matrix exteriorization. DATA SOURCES: Systematic MEDLINE and Web of Science searches identified publications describing hearing results after cholesteatoma matrix removal or matrix exteriorization. REVIEW METHODS: Three reviewers appraised the studies for quality, level of evidence, and extracted data...
January 1, 2017: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/28069077/successful-obliteration-of-troublesome-and-chronically-draining-cavities
#3
S Geerse, F A Ebbens, M J F de Wolf, E van Spronsen
OBJECTIVE: This study aimed to evaluate the results of revision radical cavity surgery with mastoid obliteration using a standardised grading scheme. METHODS: A retrospective study was performed of 121 patients (122 ears) with chronically draining ears who underwent revision radical cavity surgery with mastoid obliteration between 2007 and 2013. Surgical indications, patient characteristics, pre- and post-operative Merchant grade, and surgical outcomes were recorded...
January 10, 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28061926/baro-otolagia-secondary-to-cholesteatoma
#4
Revadi Govindaraju, Meenakshi Adaikappan, Raman Rajagopalan
BACKGROUND: Baro-otalgia is a common complaint among passengers in an aircraft, in particular those who had a recent upper respiratory tract infection. The underlying pathophysiology is secondary to unequal aeration of the middle ear cleft with the surrounding atmosphere and it can be explained using Boyle's Law. We describe an unusual presentation of baro-otalgia in a pilot secondary to cholesteatoma obstructing the aditus despite normal middle ear pressure equalization provided by a grommet in the ear...
January 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28059056/eaono-jos-joint-consensus-statements-on-the-definitions-classification-and-staging-of-middle-ear-cholesteatoma
#5
REVIEW
Matthew Yung, Tetsuya Tono, Ewa Olszewska, Yutaka Yamamoto, Holger Sudhoff, Masafumi Sakagami, Jef Mulder, Hiromi Kojima, Armağan İncesulu, Franco Trabalzini, Nuri Özgirgin
The European Academy of Otology and Neurotology (EAONO) has previously published a consensus document on the definitions and classification of cholesteatoma. It was based on the Delphi consensus methodology involving the broad EAONO membership. At the same time, the Japanese Otological Society (JOS) had been working independently on the "Classification and Staging of Cholesteatoma." EAONO and JOS then decided to collaborate and produce a joint consensus document. The EAONO/JOS joint consensus on "Definitions, Classification and Staging of Middle Ear Cholesteatoma" was formally presented at the 10th International Conference on Cholesteatoma and Ear Surgery in Edinburgh, June 5-8, 2016...
6, 2017: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/28050207/is-there-a-system%C3%A4-c-inflammatory-effect-of-cholesteatoma
#6
M Mustafa Kılıçkaya, Giray Aynali, Mustafa Tuz, Özkan Bagcı
Introduction Inflammation causes squamous epithelial transformation of the mucosa in the middle ear cavity and plays a role in the onset, growth, spread, and recurrence of cholesteatoma. Objectives The objective of this study is to investigate the systemic inflammatory effect in chronic otitis with cholesteatoma. Methods The study included a total of 311 patients comprising 156 patients with a pathology diagnosis of cholesteatoma and a control group of 155 with no active inflammation. The Neutrophil-to-lymphocyte Ratio (NLR) was calculated by dividing the neutrophil value by the lymphocyte value...
January 2017: International Archives of Otorhinolaryngology
https://www.readbyqxmd.com/read/28041650/attic-cholesteatoma-with-closure-of-the-entrance-to-pars-flaccida-retraction-pocket
#7
Shingo Matsuzawa, Yukiko Iino, Daiki Yamamoto, Masayo Hasegawa, Mariko Hara, Akihiro Shinnabe, Hiromi Kanazawa, Naohiro Yoshida
We report three patients with pars flaccida-type cholesteatoma (attic cholesteatoma) with closure of the entrance to the cholesteatoma at the time of surgery. These patients were diagnosed with attic cholesteatoma requiring surgery on the basis of abnormal findings of the pars flaccida, audiometry, and temporal bone computed tomography during the clinical course. Intraoperatively, cholesteatoma matrix and granulation tissue were observed behind the intact pars flaccida epithelium, which suggested that the entrance had apparently closed and the continuity with the cholesteatoma matrix disappeared after resolution of inflammation at the pars flaccida...
December 29, 2016: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28031158/an-iatrogenic-cholesteatoma-of-the-squamous-part-of-the-temporal-bone
#8
Daniela Páez Mantilla, Claudio Krstulovic, Manuel Mateos Fernández, Herminio Pérez Garrigues
A cholesteatoma is a relatively common condition within the middle ear cavity, whereas a cholesteatoma of the squamous part of the temporal bone is an exceptionally rare entity. A case of an iatrogenic cholesteatoma located in the squamous part of the temporal bone is presented, which was revealed by an intermittent purulent discharge from an opening above the right ear 20 years after retroauricular myringoplasty. The diagnosis of an iatrogenic cholesteatoma is often made after several years of evolution, sometimes even at the stage of complications...
December 2016: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/28031154/single-administration-of-a-sustained-release-formulation-of-kb-r7785-inhibits-tympanic-membrane-regeneration-in-an-animal-model
#9
Peter Luke Santa Maria, Chloe Santa Maria, Sungwoo Kim, Yunzhi Peter Yang
OBJECTIVE: A pressure equalization tube placed within the tympanic membrane is the only clinically available method for inhibiting tympanic membrane regeneration. Problems associated with this include associated otorrhea, biofilm formation, medial migration of the tube, tube retention, induction of granulation tissue, and a small but significant rate of cholesteatoma. We aimed to demonstrate that a single administration of a sustained-release polymer formulation of KB-R7785 maintains tympanic membrane perforation for at least 6 months...
December 2016: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/28024134/-acute-mastoiditis-with-retroauricular-abscess-a-report-of-two-cases
#10
Andrzej Misiak
Otogenic complications may occur as a result of both acute and chronic otitis media. The purpose of the diagnostic process and treatment of patients with otogenic complications is to identify and eliminate focal points of the infection. Due to general application of antibiotics, these complications are rarely observed. Retroauricular abscess may be the first symptom associated with the development of acute mastoiditis in patients with communication disturbances. Intravenous antibiotics and surgery have been successfully used for treatment in the two described cases...
December 22, 2016: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28012524/a-pearl-in-the-ear-intracranial-complications-of-pediatric-cholesteatomas
#11
Krystyne Basa, Jessica R Levi, Erin Field, Robert C O'Reilly
A nine-year-old male had a cholesteatoma of the mastoid and middle ear found incidentally after myringotomy tube placement. Associated asymptomatic sigmoid plate dehiscence with sinus invasion or thrombosis and ossicular chain destruction complicated his case. He had canal wall down tympanomastoidectomy and was followed for 4.5 years. Disease recurrence necessitated revision. Our case highlights an unusual clinical presentation, possible complications, and the aggressive quality of a benign lesion common in the pediatric population...
January 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/27999999/cartilage-island-on-stapes-autologous-porp-in-the-hypoventilated-middle-ear
#12
Jeanette Hess-Erga, Bart Lambertus Henricus Jozef Engelen, Flemming Slinning Vassbotn
The most common technique in sound restoration of the middle ear is prosthetic surgery. Hypoventilation of the middle ear may cause adhesive otitis or atelectasis resulting in a higher risk of prosthetic extrusion rate and recurrence of the underlying cholesteatoma. We report long-term results using an island of tragal cartilage as an autologous PORP in selected patients with poor middle ear ventilation. Retrospective chart reviews were performed for procedures involving 52 patients between year 2000 and 2009...
December 20, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27995828/single-dose-intratympanic-mesna-application-inhibits-propylene-glycol-induced-cholesteatoma-formation
#13
O Ismi, Y Y Karabulut, K K Bal, Y Vayisoglu, M Unal
OBJECTIVE: Mesna (i.e. sodium 2-mercaptoethanesulfonate; C2H5NaO3S2) has been used in otological surgery such as cholesteatoma dissection and tympanic membrane lateralisation in atelectatic ears. However, this study aimed to investigate its effect on cholesteatoma formation. METHODS: A total of 20 Wistar rats were divided into two groups of 10 animals. The right and left ears of control animals were treated with saline (saline control group; n = 10 ears) and propylene glycol plus saline (propylene glycol control group; n = 10 ears), respectively...
December 20, 2016: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/27992946/balloon-tuboplasty-in-patients-with-eustachian-tube-dysfunction-a-prospective-study-in-39-patients-55-ears
#14
Philippe F Bowles, Satish Agrawal, Mahmoud A Salam
Eustachian tube dysfunction (ETD) is estimated to affect approximately 1% of the UK population.(1) ETD and subsequent inadequate middle ear ventilation has been implicated in the pathogenesis of otological diseases including otitis media with effusion (OME), retraction pockets, tympanic membrane (TM) perforation and cholesteatoma.(2) This article is protected by copyright. All rights reserved.
December 19, 2016: Clinical Otolaryngology
https://www.readbyqxmd.com/read/27989248/effect-of-surgical-intervention-on-middle-ear-cholesteatoma-with-associated-facial-paralysis
#15
Y Ozkul, M Songu, K Onal, A Imre, S Arslanoglu, E Horoz, F Bayrak, E Pinar
OBJECTIVES: To investigate the presenting symptoms, intra-operative findings and long-term facial nerve function in patients treated for cholesteatoma with associated facial paralysis. METHODS: Fifteen patients with facial paralysis due to middle-ear cholesteatoma who underwent tympanomastoidectomy surgery from February 2000 to February 2015 were retrospectively reviewed. After removal of the cholesteatoma, a limited area of the fallopian canal, in which facial nerve oedema or redness was evident, was opened...
December 19, 2016: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/27981350/the-role-of-bone-resorption-in-the-etiopathogenesis-of-acquired-middle-ear-cholesteatoma
#16
REVIEW
Shumin Xie, Xiaoli Wang, Jihao Ren, Wei Liu
Cholesteatoma is a destructive squamous epithelial lesion of the temporal bone which gradually expands and leads to serious complications by destruction of nearby bony structures. Erosion caused by bone resorption of the ossicular chain and bony labyrinth may result in hearing loss, vestibular dysfunction, facial paralysis, labyrinthine fistulae and intracranial complications. The exact underlying cellular and molecular mechanism of bone resorption in acquired cholesteatoma still remains unexplained. Pubmed database and China National Knowledge Infrastructure were screened for articles focusing on bone resorption in acquired cholesteatoma...
December 16, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27942603/clinical-aspects-and-surgical-outcomes-of-congenital-cholesteatoma-in-93-children-increasing-trends-of-congenital-cholesteatoma-from-1997-through-2012
#17
Hyun Soo Cho, Hak Geon Kim, Da Jung Jung, Jeong Hun Jang, Sang Heun Lee, Kyu-Yup Lee
BACKGROUND AND OBJECTIVES: The recent increase in the reported incidence of congenital cholesteatoma (CC) may be secondary to the widespread use of otoendoscopy as well as an increased awareness of these lesions among primary care physicians. However, little research about CC has been conducted in a large group of patients. This study aimed to analyze the clinical characteristics of CC including the annual number of patients, symptoms, age at diagnosis, stage and type of disease, surgical techniques, recurrence, and postoperative complications...
December 2016: Journal of Audiology & Otology
https://www.readbyqxmd.com/read/27934908/trem-2-promotes-acquired-cholesteatoma-induced-bone-destruction-by-modulating-tlr4-signaling-pathway-and-osteoclasts-activation
#18
Huaili Jiang, Yu Si, Zhuohao Li, Xi Huang, Suijun Chen, Yiqing Zheng, Guo Xu, Ximing Chen, Yubin Chen, Yi Liu, Hao Xiong, Qiuhong Huang, Maojin Liang, Zhigang Zhang
Triggering receptor expressed on myeloid cells (TREM) has been broadly studied in inflammatory disease. However, the expression and function of TREM-2 remain undiscovered in acquired cholesteatoma. The expression of TREM-2 was significantly higher in human acquired cholesteatoma than in normal skin from the external auditory canal, and its expression level was positively correlated with the severity of bone destruction. Furthermore, TREM-2 was mainly expressed on dendritic cells (DCs). In human acquired cholesteatoma, the expression of proinflammatory cytokines (IL-1β, TNF-α and IL-6) and matrix metalloproteinases (MMP-2, MMP-8 and MMP-9) were up-regulated, and their expression levels were positively correlated with TREM-2 expression...
December 9, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27928451/bilateral-external-ear-canal-osteomas-discussion-on-a-clinical-case
#19
Gheorghe Dc, Stanciu Ae, Ulici A, Zamfir-Chiru-Anton A
Osteomas of the external ear are uncommon benign tumors that need to be differentiated from the external ear canal exostoses, bony proliferations that are linked mainly to cold-water exposure. Clinical manifestations vary from no symptoms to recurrent local infections and external ear cholesteatoma. Objective: presenting a rare case that we did not find described in the published literature. A patient with multiple long-term asymptomatic osteomas of both external ear canals presented to our department. Material: Data recorded from the patient's medical record was reviewed and analyzed...
October 2016: Journal of Medicine and Life
https://www.readbyqxmd.com/read/27921171/computed-tomography-and-magnetic-resonance-fusion-imaging-in-cholesteatoma-preoperative-assessment
#20
Agustín Campos, Federico Mata, Rosa Reboll, María Luisa Peris, Jorge Basterra
The purpose of this study is to describe a method for developing fusion imaging for the preoperative evaluation of cholesteatoma. In 33 patients diagnosed with cholesteatoma, a high-resolution temporal bone computed tomography (CT) scan without intravenous contrast and propeller diffusion-weighted magnetic resonance imaging (MRI) were performed. Both studies were then sent to the BrainLAB work station, where the images were fused to obtain a morphological and color map. Intraoperative findings coincided with fusion CT-MRI imaging in all but two patients...
December 5, 2016: European Archives of Oto-rhino-laryngology
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