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Cheng-Yun Jin, Ilandarage Menu Neelaka Molagoda, Wisurumuni Arachchilage Hasitha Maduranga Karunarathne, Sang-Hyuck Kang, Cheol Park, Gi-Young Kim, Yung Hyun Choi
Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) can preferentially initiate apoptosis in malignant cells with minimal toxicity to normal cells. Unfortunately, many human cancer cells are refractory to TRAIL-induced apoptosis through many unknown mechanisms. Here, we report that TRAIL resistance can be reversed in human bladder cancer cell lines by treatment with sulforaphane (SFN), a well-known chemopreventive isothiocyanate in various cruciferous vegetables. Combined treatment with SFN and TRAIL (SFN/TRAIL) significantly induced apoptosis concomitant with activation of caspases, loss of mitochondrial membrane potential (MMP), Bid truncation, and induction of death receptor 5...
May 21, 2018: Toxicology and Applied Pharmacology
Akinori Yanaka
The human gastrointestinal tract is exposed to a variety of toxic agents, such as Helicobacter pylori (H.pylori), nonsteroidal anti-inflammatory drugs (NSAIDs), gastric acid, enteric pathogenic bacteria, excessive auto immune reactions, and chronic mental stresses. These stressors generate free radicals within the gastrointestinal tissues, causing chronic inflammatory diseases, ulcers, cancers, and functional disturbances. Recent studies have demonstrated that some natural food compounds upregulate the nuclear factor erythroid 2-related factor 2-mediated antioxidant system, ameliorating or preventing these disorders...
May 21, 2018: Current Pharmaceutical Design
Sophia Wedel, Maria Manola, Maria Cavinato, Ioannis P Trougakos, Pidder Jansen-Dürr
Organismal ageing is associated with increased chance of morbidity or mortality and it is driven by diverse molecular pathways that are affected by both environmental and genetic factors. The progression of ageing correlates with the gradual accumulation of stressors and damaged biomolecules due to the time-dependent decline of stress resistance and functional capacity, which eventually compromise cellular homeodynamics. As protein machines carry out the majority of cellular functions, proteome quality control is critical for cellular functionality and is carried out through the curating activity of the proteostasis network (PN)...
May 19, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Giana Blume Corssac, Cristina Campos-Carraro, Alexandre Hickmann, Alex Sander da Rosa Araujo, Rafael Oliveira Fernandes, Adriane Belló-Klein
The aim of this study was to analyse the effect of sulforaphane (SFN) in cultures of adult cardiomyocytes, evaluating oxidative stress at different times. Cells were isolated, cultured, and divided into 4 groups: Control, SFN (5μM), H2 O2 (5μM), and SFN+H2 O2 (5μM both), and subdivided into groups undergoing 1 or 24 h of SFN incubation. After 1 h of incubation, reactive oxygen species production was 40% lower in the SFN group than the Control, and lipid peroxidation was 63% higher in the H2 O2 group than the Control, and it was reduced in both of the SFN groups...
May 14, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Yuanyuan Li, Phillip Buckhaults, Shizhao Li, Trygve O Tollefsbol
Breast cancer is the most common cancer and the second leading cause of cancer death among women. An important risk factor for breast cancer is individual genetic background which is initially generated early in human life; for example, during the processes of embryogenesis and fetal development in utero. Bioactive dietary components such as sulforaphane (SFN), an isothiocyanate from cruciferous vegetables including broccoli sprouts (BSp), cabbage and kale, has been shown to reduce the risk of developing many common cancers through regulation of epigenetic mechanisms...
May 15, 2018: Cancer Prevention Research
Bashar S Staitieh, Eduardo E Egea, Xian Fan, Adaugo Amah, David M Guidot
BACKGROUND: Alcohol significantly impairs antioxidant defenses and innate immune function in the lung and increases matrix metalloproteinase 9 (MMP-9) activity. The receptor for advanced glycation end products (RAGE) is a well-characterized marker of lung injury that is cleaved by MMP-9 into soluble RAGE and has not yet been examined in the alcoholic lung. We hypothesized that chronic alcohol ingestion would impair RAGE signaling via MMP-9 in the alveolar macrophage and thereby impair innate immune function...
May 2018: American Journal of the Medical Sciences
Peng Liu, Wei Wang, Zhigang Zhou, Andrew J O Smith, Richard P Bowater, Ian Michael Wormstone, Yuqiong Chen, Yongping Bao
Sulforaphane (SFN) exhibits chemopreventive effects through various mechanisms. However, few studies have focused on the bioactivities of its metabolites. Here, three metabolites derived from SFN were studied, known as sulforaphane glutathione, sulforaphane cysteine and sulforaphane- N -acetylcysteine. Their effects on cell viability, DNA damage, tumorigenicity, cell migration and adhesion were measured in human hepatoma HepG2 cells, and their anti-angiogenetic effects were determined in a 3D co-culture model of human umbilical vein endothelial cells (HUVECs) and pericytes...
May 9, 2018: Nutrients
Tao Fan, Zhixin Huang, Wei Wang, Boyou Zhang, Yao Xu, Zhangfan Mao, Lei Chen, Hao Hu, Qing Geng
Alveolar macrophages play vital roles in acute lung injury, and macrophage response to hypoxia play relevant roles to disease mechanisms. There is growing evidence that cell death pathways play crucial roles in physiological and pathological settings and that the ubiquitin-proteasome system is involved in the regulation of these processes. However, the functional role of proteasome in alveolar macrophages exposed to hypoxia-reoxygenation (H/R) injury is unknown. We aimed to investigate the function of proteasome on alveolar macrophages exposed to H/R and the underlying mechanisms...
May 9, 2018: Journal of Cellular Physiology
Jana Fechner, Martin Kaufmann, Corinna Herz, Daniela Eisenschmidt, Evelyn Lamy, Lothar W Kroh, Franziska S Hanschen
Rocket is rich in glucosinolates and valued for its hot and spicy taste. Here we report the structure elucidation, bioactivity, and stability of the mainly formed glucosinolate hydrolysis product, namely sativin, which was formerly thought to be 4-mercaptobutyl isothiocyanate. However, by NMR characterization we revealed that sativin is in fact 1,3-thiazepane-2-thione, a tautomer of 4-mercaptobutyl isothiocyanate with 7-membered ring structure and so far unknown. This finding was further substantiated by conformation sampling using molecular modeling and total enthalpy calculation with density functional theory...
September 30, 2018: Food Chemistry
Mohammed Sani Jaafaru, Nurul Ashikin Abd Karim, Mohamad Eliaser Enas, Patrick Rollin, Emanuela Mazzon, Ahmad Faizal Abdull Razis
Crucifer vegetables, Brassicaceae and other species of the order Brassicales, e.g., Moringaceae that are commonly consumed as spice and food, have been reported to have potential benefits for the treatment and prevention of several health disorders. Though epidemiologically inconclusive, investigations have shown that consumption of those vegetables may result in reducing and preventing the risks associated with neurodegenerative disease development and may also exert other biological protections in humans...
May 8, 2018: Nutrients
Małgorzata Milczarek, Katarzyna Wiktorska, Lidia Mielczarek, Mirosława Koronkiewicz, Aleksandra Dąbrowska, Katarzyna Lubelska, Dariusz Matosiuk, Zdzisław Chilmonczyk
No abstract text is available yet for this article.
May 3, 2018: Food and Chemical Toxicology
Peng Lei, Wei Zhao, Bo Pang, Xiuli Yang, Bao-Long Li, Minghua Ren, Yu-Juan Shan
The potential efficacy of sulforaphane in protecting alcohol-induced hepatic injury in vivo and its underlying mechanism was investigated. Male C57BL/6 mice were orally administrated with broccoli sprout extract (BSE) containing sulforaphane (7.6, 25.2, 50.4 mg/ once a day for 14 days. At the 13th day, mice were challenged with alcohol (5g/ every 12 h for 3 times, which increased malondialdehyde (MDA) levels (4.44±1.24 nmol/mg prot, p<0.01) in liver. Our results showed that low, medium and high dose BSE markedly reversed the decrease of antioxidant capacity through enhancing glutathione (GSH) (2...
May 6, 2018: Journal of Agricultural and Food Chemistry
Md Sadikuj Jaman, Md Abu Sayeed
Globally, breast cancer is the most common cancer and the second leading cause of cancer-related death among women. Surgery, chemotherapy, hormonal therapy, and radiotherapy are currently available treatment options for breast cancer therapy. However, chemotherapy, hormonal therapy, and radiotherapy are often associated with side effects and multidrug resistance, recurrence, and lack of treatment in metastasis are the major problems in the treatment of breast cancer. Recently, dietary phytochemicals have emerged as advantageous agents for the prevention and therapy of cancer due to their safe nature...
May 3, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
Beate Hegge, Eva Sjøttem, Ingvild Mikkola
BACKGROUND: The transcription factor PAX6 is expressed in various cancers. In anaplastic astrocytic glioma, PAX6 expression is inversely related to tumor grade, resulting in low PAX6 expression in Glioblastoma, the highest-grade astrocytic glioma. The aim of the present study was to develop a PAX6 knock out cell line as a tool for molecular studies of the roles PAX6 have in attenuating glioblastoma tumor progression. METHODS: The CRISPR-Cas9 technique was used to knock out PAX6 in U251 N cells...
May 2, 2018: BMC Cancer
Siyoung Lee, Bo-Ryoung Choi, Jisung Kim, Frank M LaFerla, Jung Han Yoon Park, Jung-Soo Han, Ki Won Lee, Jiyoung Kim
SCOPE: Sulforaphane is an herbal isothiocyanate enriched in cruciferous vegetables. Here, we investigated whether sulforaphane modulates the production of amyloid-β (Aβ) and tau, the two main pathological factors in Alzheimer's disease (AD). METHODS AND RESULTS: A triple transgenic mouse model of AD (3 × Tg-AD) was used to study the effect of sulforaphane. Oral gavage of sulforaphane reduced protein levels of monomeric and polymeric forms of Aβ as well as tau and phosphorylated tau in 3 × Tg-AD mice...
April 30, 2018: Molecular Nutrition & Food Research
Chang-Tai Chen, Ming-Ju Hsieh, Yi-Hsien Hsieh, Min-Chieh Hsin, Yi-Ting Chuang, Shun-Fa Yang, Jia-Sin Yang, Chiao-Wen Lin
Sulforaphane has been demonstrated to exert numerous biological effects, such as neuroprotective, anti-inflammatory, and anticancer effects. However, the detailed effects of sulforaphane on human oral cancer cell migration and the underlying mechanisms remain unclear. In this study, we observed that sulforaphane attenuated SCC-9 and SCC-14 cell motility and invasiveness by reducing cathepsin S expression. Moreover, sulforaphane increased microtubule-associated protein 1 light chain 3 (LC3) conversion, and the knockdown of LC3 by siRNA increased cell migration ability...
April 3, 2018: Oncotarget
Passant E Moustafa, Noha F Abdelkader, Sally A El Awdan, Osama A El-Shabrawy, Hala F Zaki
The peripheral nervous system is one of many organ systems that can be profoundly impacted in diabetes mellitus. Diabetic peripheral neuropathy has a significant negative effect on patients' quality of life as it begins with loss of limbs' sensation and may result in lower limb amputation. This investigation aimed at exploring the effect of sulforaphane on peripheral neuropathy in diabetic rats. Experimental diabetes was induced through single intraperitoneal injections of nicotinamide (50 mg/kg) and streptozotocin (52...
April 27, 2018: Inflammation
Alfredo Briones-Herrera, Dianelena Eugenio-Pérez, Jazmin Gabriela Reyes-Ocampo, Susana Rivera-Mancía, José Pedraza-Chaverri
In this paper, we review recent evidence about the beneficial effects of sulforaphane (SFN), which is the most studied member of isothiocyanates, on both in vivo and in vitro models of different diseases, mainly diabetes and cancer. The role of SFN on oxidative stress, inflammation, and metabolism is discussed, with emphasis on those nuclear factor E2-related factor 2 (Nrf2) pathway-mediated mechanisms. In the case of the anti-inflammatory effects of SFN, the point of convergence seems to be the downregulation of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), with the consequent amelioration of other pathogenic processes such as hypertrophy and fibrosis...
April 27, 2018: Food & Function
João Francisco Silva Rodrigues, Cristiane Silva E Silva, Thayanne França Muniz, Alana Fernanda de Aquino, Larissa Neuza da Silva Nina, Nagila Caroline Fialho Sousa, Luis Claudio Nascimento da Silva, Breno Glaessner Gomes Fernandes de Souza, Tatiana Aranha da Penha, Ana Lúcia Abreu-Silva, Joicy Cortez de Sá, Elizabeth Soares Fernandes, Marcos Augusto Grigolin Grisotto
Rheumatoid arthritis (RA) is characterized by inflammation of one or more joints, and affects ~1% of the adult population worldwide. Sulforaphane (SFN) is a natural compound that has been suggested as an antioxidant. Here, SFN&rsquo;s effects were evaluated in a murine mono-arthritis model. Mono-arthritis was induced in mice by a single intra-articular injection of Complete Freund&rsquo;s Adjuvant (CFA-10 &micro;g/joint, in 10 &micro;L) into the ipsilateral joint. The contralateral joint received an equal volume of PBS...
April 24, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Shawn Tahata, Shivendra V Singh, Yan Lin, Eun-Ryeong Hahm, Jan H Beumer, Susan M Christner, Uma N Rao, Cindy Sander, Ahmad A Tarhini, Hussein Tawbi, Laura K Ferris, Melissa Wilson, Amy Rose, Catherine M Dietz, Ellen K Hughes, Jed W Fahey, Sancy A Leachman, Pamela B Cassidy, Lisa H Butterfield, Hassane M Zarour, John M Kirkwood
Broccoli sprout extract containing sulforaphane (BSE-SFN) has been shown to inhibit ultraviolet radiation-induced damage and tumor progression in skin. This study evaluated the toxicity and potential effects of oral BSE-SFN at three dosages. Seventeen patients who each had at least 2 atypical nevi and a prior history of melanoma were randomly allocated to 50, 100, or 200 µmol oral BSE-SFN daily for 28 days. Atypical nevi were photographed on days 1 and 28, and plasma and nevus samples were taken on days 1, 2, and 28...
April 24, 2018: Cancer Prevention Research
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