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https://www.readbyqxmd.com/read/29238105/relationship-between-patellar-mobility-and-patellofemoral-joint-cartilage-degeneration-after-anterior-cruciate-ligament-reconstruction
#1
Susumu Ota, Kazutoshi Kurokouchi, Shigeo Takahashi, Masaki Yoda, Ryuichiro Yamamoto, Tadahiro Sakai
Patellofemoral cartilage degeneration is a potential complication of anterior cruciate ligament reconstruction (ACLR) surgery. Hypomobility of the patella in the coronal plane is often observed after ACLR. Few studies, however, have examined the relationship between cartilage degeneration in the patellofemoral joint and mobility after ACLR. The present study investigated 1) the coronal mobility of the patella after ACLR, 2) the relationship between patellar mobility and cartilage degeneration of the patellofemoral joint, and 3) the relationship between patellar mobility and knee joint function after ACLR...
November 2017: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/29233163/intra-articular-injection-of-expanded-autologous-bone-marrow-mesenchymal-cells-in-moderate-and-severe-knee-osteoarthritis-is-safe-a-phase-i-ii-study
#2
Mahasen Al-Najar, Hiba Khalil, Jihad Al-Ajlouni, Eman Al-Antary, Mohammad Hamdan, Reem Rahmeh, Dana Alhattab, Osama Samara, Mohamad Yasin, Amenah Al Abdullah, Esraa Al-Jabbari, Dima Hmaid, Hanan Jafar, Abdalla Awidi
BACKGROUND: Knee osteoarthritis (KOA) is a major health problem especially in the aging population. There is a need for safe treatment that restores the cartilage and reduces the symptoms. The use of stem cells is emerging as a possible option for the moderate and severe cases. This study aimed at testing the safety of autologous bone marrow mesenchymal stem cells (BM-MSCs) expanded in vitro when given intra-articularly to patients with stage II and III KOA. As a secondary end point, the study tested the ability of these cells to relieve symptoms and restore the knee cartilage in these patients as judged by normalized knee injury and Osteoarthritis Outcome Score (KOOS) and by magnetic resonance imaging (MRI)...
December 12, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29227373/incidence-of-meniscal-entrapment-and-associated-knee-injuries-in-tibial-spine-avulsions
#3
Jason T Rhodes, Peter C Cannamela, Aristides I Cruz, Meredith Mayo, Alexandra C Styhl, Connor G Richmond, Theodore J Ganley, Kevin G Shea
BACKGROUND: Tibial spine avulsions (TSA) have historically been treated as isolated injuries. Data on associated injuries are limited with existing literature reporting wide ranging incidences. The purpose of this multicenter study was to (1) describe the incidence of meniscal entrapment and associated knee injuries in TSA and to (2) compare surgical and magnetic resonance image (MRI) findings for these injuries. Our hypothesis is that tibial spine injuries are not usually isolated injuries, and other meniscal, ligament, and cartilage injuries may be present...
December 8, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/29226660/bone-and-joint-diseases-in-present-and-future
#4
Yasuharu Nakashima, Ken Okazak, Koichiet Nakayama, Seiji Okada, Hideki Mizu-uchi
With the increase of elderly population, orthopaedic surgeons need to deal with the diseases related to aging, such as joint disorders and fragility fractures. The number of total joint replacements, for example, is two times more than it was 10 years ago. With these backgrounds, the Japanese Orthopaedic Association (JOA) has proposed the concept of locomotive syndrome; conditions under which the elderly have been receiving care services due to problems of the locomotive organs. To prevent geriatric or disuse syndrome, JOA is currently providing the care‒prevention programs such as the loco-check and loco-training...
January 2017: Fukuoka Igaku Zasshi, Hukuoka Acta Medica
https://www.readbyqxmd.com/read/29226656/peripheral-blood-mir-181-5p-serves-as-a-marker-for-screening-patients-with-osteoarthritis-by-targeting-tnf%C3%AE
#5
Silong Xia, Hua Tian, Lei Fan, Jianying Zheng
BACKGROUND: Increasing evidence has suggested the important role of miRNAs in the progression of osteoarthritis (OA). In the current study, we explored the role of miR-181-5p in the peripheral blood and bone tissues of OA patients for the first time. METHODS: The level of miR-181-5p was evaluated in the peripheral blood and cartilage of OA patients using real time PCR analysis. ROC analysis was performed to explore whether peripheral blood and cartilage miR-181-5p could screen OA patients from normal controls...
November 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/29225159/histopathology-of-periarticular-non-hereditary-heterotopic-ossification
#6
REVIEW
Kristin L Foley, Nader Hebela, Mary Ann Keenan, Robert J Pignolo
In the mature adult skeleton, new bone formation is normally restricted to regeneration of osseous tissue at sites of fracture. However, heterotopic ossification, or the formation of bone outside the normal skeleton, can occur within muscle, adipose, or fibrous connective tissue. Periarticular non-hereditary heterotopic ossification (NHHO) may occur after musculoskeletal trauma, following CNS injury, with certain arthropathies, or following injury or surgery that is often sustained in the context of age-related pathology...
December 7, 2017: Bone
https://www.readbyqxmd.com/read/29225019/primary-versus-revision-anterior-cruciate-ligament-reconstruction-patient-demographics-radiographic-findings-and-associated-lesions
#7
Justin J Mitchell, Mark E Cinque, Grant J Dornan, Lauren M Matheny, Chase S Dean, Brad Kruckeberg, Gilbert Moatshe, Jorge Chahla, Robert F LaPrade
PURPOSE: The purpose of this study was to evaluate the differences in intra-articular pathology, demographic characteristics, and radiographic characteristics of the knee associated with primary anterior cruciate ligament reconstruction (ACLR) versus revision ACLR at the time of initial presentation with either a native anterior cruciate ligament tear or an anterior cruciate ligament graft tear. Secondarily, we aimed to investigate risk factors for concomitant medial and lateral meniscal tears and cartilage injuries at the time of ACLR...
December 7, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29225015/symptomatic-focal-knee-chondral-injuries-in-national-football-league-combine-players-are-associated-with-poorer-performance-and-less-volume-of-play
#8
Matthew T Provencher, Jorge Chahla, Mark E Cinque, George Sanchez, Nicholas I Kennedy, Daniel B Haber, Ashley J Tisosky, Brendin R Beaulieu-Jones, Mark D Price, James M Whalen, Gilbert Moatshe, Robert F LaPrade
PURPOSE: To (1) describe the magnetic resonance imaging (MRI) characteristics of knee chondral injuries identified at the National Football League (NFL) Combine and (2) assess in-game performance of prospective NFL players with previously untreated knee chondral injuries and compare it with matched controls. METHODS: All players with knee chondral injuries identified at the NFL Combine (2009-2015) were retrospectively reviewed. Players with prior knee surgery were excluded...
December 7, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29224757/reproducing-severe-acute-subglottic-stenosis-in-a-rabbit-model
#9
Wesley R McIlwain, Paul R Wistermayer, Tyler P Swiss, Shannon T Marko, Nicholas M Ieronimakis, Derek J Rogers
OBJECTIVES: The objectives of this study were to develop an animal model with consistent, severe subglottic stenosis (SGS), and to develop the timeline needed for intervention to limit rabbit mortality. METHODS: Subglottic stenosis was created endoscopically using either a nylon or polypropylene brush in sixteen New Zealand White rabbits. The subglottic cross-sectional area was measured endoscopically using a right-angled probe and an open source image analysis software The cross-sectional areas of the stenotic and native airways were compared to calculate the subglottic stenosis percentage and Myer-Cotton grade classification...
December 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29223595/modulation-of-cartilage-s-response-to-injury-can-chondrocyte-apoptosis-be-reversed
#10
REVIEW
Ippokratis Pountos, Peter V Giannoudis
Osteoarthritis is characterized by a chronic, progressive and irreversible degradation of the articular cartilage associated with joint inflammation and a reparative bone response. More than 100 million people are affected by this condition worldwide with significant health and welfare costs. Our available treatment options in osteoarthritis are extremely limited. Chondral or osteochondral grafts have shown some promising results but joint replacement surgery is by far the most common therapeutic approach. The difficulty lies on the limited regeneration capacity of the articular cartilage, poor blood supply and the paucity of resident progenitor stem cells...
December 2017: Injury
https://www.readbyqxmd.com/read/29222584/-preservation-of-the-outer-ear-in-a%C3%A2-complex-burn-injury
#11
Fabian Medved, Hans-Eberhard Schaller, Jens Martin Rothenberger, Manuel Held, Kevin Beutler, Cedric E Boesch
Saving the outer ear in burn injuries is a challenging task for the treating surgeon that should not be underestimated. Burns which are initially evaluated as superficial, particularly in this region, often have a tendency to undergo progressive tissue destruction whereby conservative treatment is often no longer sufficient to preserve the skin of the auricle with the underlying cartilage. Various possibilities for saving the ear and for ear reconstruction are described, but in the case of severely burned patients it is often necessary to carry out a quick and relatively simple treatment...
December 8, 2017: Der Unfallchirurg
https://www.readbyqxmd.com/read/29221902/a-comparison-of-patellofemoral-cartilage-morphology-and-deformation-in-anterior-cruciate-ligament-deficient-versus-uninjured-knees
#12
Kwadwo A Owusu-Akyaw, Lauren N Heckelman, Hattie C Cutcliffe, E Grant Sutter, Zoë A Englander, Charles E Spritzer, William E Garrett, Louis E DeFrate
Anterior cruciate ligament (ACL) deficient patients have an increased rate of patellofemoral joint (PFJ) osteoarthritis (OA) as compared to the general population. Although the cause of post-injury OA is multi-factorial, alterations in joint biomechanics may predispose patients to cartilage degeneration. This study aimed to compare in vivo PFJ morphology and mechanics between ACL deficient and intact knees in subjects with unilateral ACL ruptures. Eight male subjects underwent baseline MRI scans of both knees...
November 27, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29212911/a-role-of-nkr-p1a-cd161-and-lectin-like-transcript-1-in-natural-cytotoxicity-against-human-articular-chondrocytes
#13
Agata Białoszewska, Joanna Olkowska-Truchanowicz, Katarzyna Bocian, Anna Osiecka-Iwan, Andrzej Czop, Claudine Kieda, Jacek Malejczyk
Normal cartilage cells are susceptible to lysis by NK cells. This phenomenon may play a role in immune cartilage destruction; however, the mechanisms of chondrocyte recognition by NK cells remain poorly understood. Therefore, the aim of this study was to reveal a possible role of NKR-P1A/lectin-like transcript 1 (LLT1) interaction in NK cell-mediated cytotoxicity against normal human articular chondrocytes. Chondrocytes were isolated from articular cartilage obtained during talonavicular joint surgery. PBMC or polyclonal NK cells isolated from normal donors served as effector cells...
December 6, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29212674/iatrogenic-articular-cartilage-injury-the-elephant-in-the-operating-theatre-the-surgeons-role-in-chondroprotection
#14
EDITORIAL
A K Amin, A H R W Simpson, A C Hall
No abstract text is available yet for this article.
December 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/29209793/degenerative-changes-after-posterior-cruciate-ligament-reconstruction-are-irrespective-of-posterior-knee-stability-mri-based-long-term-results
#15
Clemens Gwinner, Andreas Weiler, Timm Denecke, Julian M M Rogasch, Heide Boeth, Tobias M Jung
INTRODUCTION: Posterior cruciate ligament reconstruction (PCLR) is advocated to prevent an early onset of osteoarthritis. We hypothesized that posterior instability after PCLR correlates with degenerative changes. MATERIALS AND METHODS: MRIs of 42 (12 female/30 male; 39 ± 9 years) patients were enrolled with a minimum 5-year follow-up (FFU) after PCLR. In addition, 25 contralateral and 15 follow-up MRIs (12 months after baseline) were performed. Degenerative changes were graded using WORMS...
December 6, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29208010/prediction-of-progression-of-damage-to-articular-cartilage-2%C3%A2-years-after-anterior-cruciate-ligament-reconstruction-use-of-aggrecan-and-type-ii-collagen-biomarkers-in-a-retrospective-observational-study
#16
Yasumori Sobue, Toshihisa Kojima, Kazutoshi Kurokouchi, Shigeo Takahashi, Hiroaki Yoshida, Robin Poole, Naoki Ishiguro
BACKGROUND: We aimed to determine whether synovial fluid (SF) biomarkers can predict the progression of articular cartilage damage as determined by arthroscopic evaluation during and after anterior cruciate ligament (ACL) reconstruction. METHODS: Arthroscopic assessment of articular cartilage damage was performed twice in 62 patients, first during ACL reconstruction and then approximately 2 years later during implant removal for ligament fixation. SF levels of the collagenase-generated cleavage neoepitope of type II collagen (C2C) and proteoglycan glycosaminoglycans keratan sulfate (KS), chondroitin-4-sulfate (Δdi-C4S), and chondroitin-6-sulfate (Δdi-C6S) were measured at ACL reconstruction...
December 6, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29207029/icariin-possesses-chondroprotective-efficacy-in-a-rat-model-of-dexamethasone-induced-cartilage-injury-through-the-activation-of-mir-206-targeting-of-cathepsin-k
#17
Ning Liu, Tao Zhang, Bo-Ran Cao, Fei-Yu Luan, Rui-Xuan Liu, Hao-Rong Yin, Wen-Bo Wang
The present study aimed to investigate the articular cartilage and chondrocytes of dexamethasone (DXM)-induced cartilage injuries in rats in response to treatment with icariin, as well as the implicated molecular mechanism. Effects of icariin on bone metabolism and articular cartilage in experimental rats were investigated. Subsequently, the present study assessed dysregulated microRNA (miRNA) in the articular cartilage of experimental rats, and validated the significant miRNA and their targets. Finally, the effects of icariin on chondrocytes in experimental rats and the implicated molecular mechanism were explored...
November 27, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29205258/sustained-intra-cartilage-delivery-of-low-dose-dexamethasone-using-a-cationic-carrier-for-treatment-of-post-traumatic-osteoarthritis
#18
A G Bajpayee, R E De la Vega, M Scheu, N H Varady, I A Yannatos, L A Brown, Y Krishnan, T J Fitzsimons, P Bhattacharya, E H Frank, A J Grodzinsky, R M Porter
Disease-modifying osteoarthritis drugs (DMOADs) should reach their intra-tissue target sites at optimal doses for clinical efficacy. The dense, negatively charged matrix of cartilage poses a major hindrance to the transport of potential therapeutics. In this work, electrostatic interactions were utilised to overcome this challenge and enable higher uptake, full-thickness penetration and enhanced retention of dexamethasone (Dex) inside rabbit cartilage. This was accomplished by using the positively charged glycoprotein avidin as nanocarrier, conjugated to Dex by releasable linkers...
December 5, 2017: European Cells & Materials
https://www.readbyqxmd.com/read/29198383/comprehensively-assessing-the-acute-femoral-cartilage-response-and-recovery-after-walking-and-drop-landing-an-ultrasonographic-study
#19
Matthew S Harkey, J Troy Blackburn, Anthony C Hackney, Michael D Lewek, Randy J Schmitz, Daniel Nissman, Brian Pietrosimone
We compared the acute response and recovery of ultrasonography (US) cartilage outcomes (i.e., thickness, cross-sectional area, and echo intensity) between walking, drop-landing and control conditions in 43 young adults with no history of lower extremity injury. A femoral cartilage US assessment was performed before and after each condition to determine the acute cartilage response and recovery at 15, 30 and 45 min. Percentage change scores from pre- to all post-time points were used for analysis. Acute cartilage response and recovery were analyzed with a 3 × 4 (condition × time) repeated-measures analysis of variance...
November 29, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29195812/effects-of-a-single-condylar-neck-fracture-without-condylar-cartilage-injury-on-traumatic-heterotopic-ossification-around-the-temporomandibular-joint-in-mice
#20
Ningjuan Ouyang, Xiaofang Zhu, Hongliang Li, Yuheng Lin, Jun Shi, Jiewen Dai, Guofang Shen
OBJECTIVES: In this study, we tried to explore the effects of a single condylar neck fracture without condylar cartilage injury during the pathogenesis process of traumatic heterotopic ossification around the temporomandibular joint (THO-TMJ). STUDY DESIGN: One-month-old C57 BL/6 J male mice were divided into 2 groups. In group 1, condylar cartilage was partially removed in the right joint to induce THO. In group 2, a single fracture on the condylar neck was created using small scissors...
November 6, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
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