keyword
MENU ▼
Read by QxMD icon Read
search

Cartilage injuries

keyword
https://www.readbyqxmd.com/read/29453795/inflammatory-and-degenerative-phases-resulting-from-anterior-cruciate-rupture-in-a-non-invasive-murine-model-of-post-traumatic-osteoarthritis
#1
Sophie Jane Gilbert, Cleo Selina Bonnet, Paulina Stadnik, Victor Colin Duance, Deborah JaneMason, Emma Jane Blain
Joint injury is the predominant risk factor for post-traumatic osteoarthritis development (PTOA). Several non-invasive mouse models mimicking human PTOA investigate molecular mechanisms of disease development; none have characterised the inflammatory response to this acute traumatic injury. Our aim was to characterise the early inflammatory phase and later degenerative component in our in vivo non-invasive murine model of PTOA induced by anterior cruciate ligament (ACL) rupture. Right knees of 12-week-old C57Bl6 mice were placed in flexion at a 30° offset position and subjected to a single compressive load (12N, 1...
February 17, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29450729/physical-activity-and-mediterranean-diet-based-on-olive-tree-phenolic-compounds-from-two-different-geographical-areas-have-protective-effects-on-early-osteoarthritis-muscle-atrophy-and-hepatic-steatosis
#2
Marta Anna Szychlinska, Paola Castrogiovanni, Francesca Maria Trovato, Houda Nsir, Mokhtar Zarrouk, Debora Lo Furno, Michelino Di Rosa, Rosa Imbesi, Giuseppe Musumeci
PURPOSE: Osteoarthitis (OA) leads to progressive loss of articular cartilage, pain and joint disability. An acute injury constitutes an important risk factor for early OA, determining an inflammatory process responsible of cartilage degeneration and muscle atrophy, due to the joint pain and immobility. The study aims to assess the effects of conjugation of physical activity and diet enriched by olive tree compounds [extra virgin olive oil (EVOO) and olive leaf extract (OLE)], on the musculoskeletal system in OA rat model...
February 15, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29450208/clinical-outcomes-after-microfracture-of-the-knee-midterm-follow-up
#3
Alexander E Weber, Philip H Locker, Erik N Mayer, Gregory L Cvetanovich, Annemarie K Tilton, Brandon J Erickson, Adam B Yanke, Brian J Cole
Background: Microfracture is a single-stage arthroscopic procedure used to treat small- and medium-sized cartilage defects, the clinical results of which have been mixed to date. Purpose: To retrospectively evaluate prospectively collected patient-reported outcomes (PROs) after microfracture as well as to determine patient-related and defect-related factors associated with clinical outcomes and which factors predict the need for additional surgery. Study Design: Case-control study; Level of evidence, 3...
February 2018: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29450207/fixation-of-traumatic-chondral-only-fragments-of-the-knee-in-pediatric-and-adolescent-athletes-a-retrospective-multicenter-report
#4
Peter D Fabricant, Yi-Meng Yen, Dennis E Kramer, Mininder S Kocher, Lyle J Micheli, J Todd R Lawrence, Theodore J Ganley, Benton E Heyworth
Background: While traditional biological principles have suggested that fragments consisting of cartilage alone cannot be reaffixed to bone with expectable long-term healing, case reports of successful healing after fixation in younger patients indicate that this concept remains incompletely explored. Purpose: To evaluate the presenting features, techniques, healing rates, and clinical and radiological results in a cohort of pediatric and adolescent athletes who underwent fixation of traumatic chondral-only fragments in the knee...
February 2018: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29448248/lncrna-gas5-overexpression-reverses-lps-induced-inflammatory-injury-and-apoptosis-through-up-regulating-klf2-expression-in-atdc5-chondrocytes
#5
Feng Li, Jianguang Sun, Shilei Huang, Gao Su, Guofu Pi
BACKGROUND/AIMS: Osteoarthritis (OA) is the most frequently occurring joint disease and characterized by degeneration of cartilage. As the unique cell type in cartilage, chondrocytes play a crucial role during OA. Our study explored the influence of long non-coding RNA (lncRNA) growth arrest-specific transcript 5 (GAS5) on lipopolysaccharides (LPS)-induced injury in ATDC5 cells. METHODS: Cell viability, apoptosis and expression of inflammatory cytokines were all assessed to evaluate LPS-induce inflammatory injury...
February 9, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29445428/the-danger-zone-in-the-anterior-neck-anatomical-landmarks-to-avoid-injury-to-anterior-jugular-vein-during-face-lift-and-neck-lift
#6
Andrew M Swiergosz, J Stephen Gunn, Steven A Schulz, Joshua T Henderson, Joshua H Choo, Arian Mowlavi, Bradon J Wilhelmi
Background : An estimated 125,711 face-lifts and 54,281 neck-lifts were performed in 2015. Regardless of the technique employed, facial and neck flap elevation carries with it anatomical risk of which any surgeon performing these procedures should be aware of. Statistics related to anterior jugular vein injury during these procedures have not been published. Objective : To define a "danger zone" that will contain both of the anterior jugular veins on the basis of anatomical landmarks to aid surgeons with planning their surgical approach during rhytidectomy in the anterior neck region...
2018: Eplasty
https://www.readbyqxmd.com/read/29441427/isolated-focal-cartilage-and-labral-defects-in-patients-with-femoroacetabular-impingement-syndrome-may-represent-new-unique-injury-patterns
#7
Ashley L Kapron, Stephen K Aoki, Jeffrey A Weiss, Aaron J Krych, Travis G Maak
PURPOSE: Develop a framework to quantify the size, location and severity of femoral and acetabular-sided cartilage and labral damage observed in patients undergoing hip arthroscopy, and generate a database of individual defect parameters to facilitate future research and treatment efforts. METHODS: The size, location, and severity of cartilage and labral damage were prospectively collected using a custom, standardized post-operative template for 100 consecutive patients with femoroacetabular impingement syndrome...
February 13, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29438746/longitudinal-changes-in-mr-t1%C3%AF-t2-signal-of-meniscus-and-its-association-with-cartilage-t1p-t2-in-acl-injured-patients
#8
Joseph Knox, Valentina Pedoia, Amy Wang, Matthew Tanaka, Gabby B Joseph, Jan Neumann, Thomas M Link, Xiaojuan Li, C Benjamin Ma
OBJECTIVE: To evaluate the longitudinal changes in meniscal T1ρ/T2 signal post-reconstruction in patients with acute anterior cruciate ligament (ACL) injury and to investigate the association with T1ρ/T2 signal in articular knee cartilage. METHOD: In this prospective study, knees of 37 patients with ACL-injury and reconstruction in addition to 13 healthy controls were scanned using magnetic resonance imaging (MRI) T1ρ/T2 mapping. Quantitative analysis of the meniscus was performed in the anterior/posterior horns of lateral/medial meniscus fourteen sub-compartments of cartilage spanning the medial/lateral area of the tibia and femoral condyles...
February 10, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29436471/drug-induced-modulation-of-gp130-signalling-prevents-articular-cartilage-degeneration-and-promotes-repair
#9
Ruzanna Shkhyan, Ben Van Handel, Jacob Bogdanov, Siyoung Lee, Yifan Yu, Mila Scheinberg, Nicholas W Banks, Sean Limfat, Arthur Chernostrik, Carlos Eduardo Franciozi, Mohammad Parvez Alam, Varghese John, Ling Wu, Gabriel B Ferguson, Ali Nsair, Frank A Petrigliano, C Thomas Vangsness, Kanagasabai Vadivel, Paul Bajaj, Liming Wang, Nancy Q Liu, Denis Evseenko
OBJECTIVE: Human adult articular cartilage (AC) has little capacity for repair, and joint surface injuries often result in osteoarthritis (OA), characterised by loss of matrix, hypertrophy and chondrocyte apoptosis. Inflammation mediated by interleukin (IL)-6 family cytokines has been identified as a critical driver of proarthritic changes in mouse and human joints, resulting in a feed-forward process driving expression of matrix degrading enzymes and IL-6 itself. Here we show that signalling through glycoprotein 130 (gp130), the common receptor for IL-6 family cytokines, can have both context-specific and cytokine-specific effects on articular chondrocytes and that a small molecule gp130 modulator can bias signalling towards anti-inflammatory and antidegenerative outputs...
February 7, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29435036/long-non-coding-rna-cartilage-injury-related-promotes-malignancy-in-bladder-cancer
#10
Xuebao Xiang, Jiefu Huang, Wenfa Mo, Leiming Jiang, Wenguo Sun, Pengcheng Li
Recent advances have highlighted the important roles of long non-coding RNAs (lncRNAs) in a number of biological processes, including oncogenesis. However, the function of lncRNA cartilage injury-related (lncRNA-CIR) in bladder cancer progression remains elusive. A novel function for lncRNA-CIR in bladder cancer was identified in the present study. Reverse transcription quantitative polymerase chain reaction, viability, invasion assay and in vivo implantation were used to evaluate the role of lncRNA-CIR. It was identified that the expression of lncRNA-CIR was frequently upregulated in 52 cancerous tissues and selected bladder cancer cell lines...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29434794/biomechanical-analysis-of-brachial-plexus-injury-availability-of-three-dimensional-finite-element-model-of-the-brachial-plexus
#11
Atsushi Mihara, Tsukasa Kanchiku, Norihiro Nishida, Haruki Tagawa, Junji Ohgi, Hidenori Suzuki, Yasuaki Imajo, Masahiro Funaba, Daisuke Nakashima, Xian Chen, Toshihiko Taguchi
Adult brachial plexus injuries frequently lead to significant and permanent physical disabilities. Investigating the mechanism of the injury using biomechanical approaches may lead to further knowledge with regard to preventing brachial plexus injuries. However, there are no reports of biomechanical studies of brachial plexus injuries till date. Therefore, the present study used a complex three-dimensional finite element model (3D-FEM) of the brachial plexus to analyze the mechanism of brachial plexus injury and to assess the validity of the model...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29429373/long-term-clinical-and-mri-results-of-matrix-assisted-autologous-chondrocyte-implantation-for-articular-cartilage-defects-of-the-knee
#12
Peter Cornelius Kreuz, Richard Horst Kalkreuth, Philipp Niemeyer, Markus Uhl, Christoph Erggelet
Objective To evaluate the long-term clinical and radiological outcome of matrix-assisted autologous chondrocyte implantation (mACI) for articular cartilage defects in the knee joint. Design Clinical evaluation was assessed in 21 patients with full-thickness cartilage defects, International Cartilage Repair Society (ICRS) grade IV. Clinical scoring was performed preoperatively and 12 years after transplantation using the International Knee Documentation Committee (IKDC) score, the Lysholm score, the Knee injury and Osteoarthritis Outcome Score (KOOS), and the Noyes sports activity rating scale...
February 1, 2018: Cartilage
https://www.readbyqxmd.com/read/29429245/-effects-of-expanded-anterolateral-approach-for-tibial-plateau-fractures-involved-the-posterolateral-column
#13
Y W Zhao, J B Xie, G Z Ding
Objective: To explore the short-term effects of expanded anterolateral approach in treating fracture involved the posterolateral tibial plateau. Methods: A retrospective analysis of the clinical data from 16 patients undergoing extended anterolateral approach for fracture involved the posterolateral tibial plateau in the First Affiliated Hospital of Wannan Medical College between January 2013 and July 2016 was done. The patients were treated with 3.5 mm proximal "L" type proximal tibial locking compression plate with four locking screws through the nail row technique...
January 30, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29427442/nose-resurfacing-with-free-fasciocutaneous-flaps-in-burns-patients
#14
Cheng-I Yen, Jui-Yung Yang, Chun-Shin Chang, Jung-Ju Huang, Chih-Wei Wu, Hung-Chang Chen, Shih-Yi Yang, Shu-Yin Chang, Shiow-Shuh Chuang, Yen-Chang Hsiao
BACKGROUND: Nasal reconstruction after burn injury can be challenging due to limited availability of local flaps. We present our experience of free flap reconstruction for full-thickness nasal defect after severe facial burn injury. METHODS: Between August 1998 and September 2015, six patients underwent nasal reconstruction with seven free flaps after burn injury. Among them, flame burn occurred in two patients, chemical burn in two, explosive burn in one, and contact thermal burn in one patient...
February 10, 2018: Microsurgery
https://www.readbyqxmd.com/read/29424164/-research-progress-on-the-etiology-and-treatment-of-patellofemoral-pain-syndrome
#15
REVIEW
Li-Hua Cui
Patellofemoral pain syndrome (PFPS) is one of the most common diseases that cause pain in the knee joint. At present, there is no specific diagnostic measure. The diagnosis of patellofemoral pain syndrome may be considered when imaging is performed without cartilage, ligament and soft tissue injuries. The etiology includes abnormalities of the patellar motion caused by various anatomical abnormalities, such as abnormal patellar position, increased Q angle, and excessive valgus foot. Dysfunction of the lower extremity muscles such as the imbalance of the four biceps and the dysfunction of the gluteal muscles also play an important role in the development of patellofemoral pain syndrome...
July 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29416975/all-inside-arthroscopic-meniscal-repair-technique-using-a-midbody-accessory-portal
#16
S Tal Hendrix, Adam Kwapisz, Douglas J Wyland
Treatment of symptomatic meniscal tears continues to evolve as we improve our understanding of the biomechanical role of the meniscus and its long-term importance to the health of the knee joint. Suture repair of meniscal tears is challenging, yet the incidence of repairs among our colleagues continues to rise as we aim to preserve meniscal tissue. Many elements of performing a repair are tedious and difficult, including proper meniscal preparation, reduction, mattress suture placement, and fixation. The tear pattern and location present another layer of difficulty...
October 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/29416028/inhibition-of-overactive-tgf-%C3%AE-attenuates-progression-of-heterotopic-ossification-in-mice
#17
Xiao Wang, Fengfeng Li, Liang Xie, Janet Crane, Gehua Zhen, Yuji Mishina, Ruoxian Deng, Bo Gao, Hao Chen, Shen Liu, Ping Yang, Manman Gao, Manli Tu, Yiguo Wang, Mei Wan, Cunyi Fan, Xu Cao
Acquired heterotopic ossification (HO) is a painful and debilitating disease characterized by extraskeletal bone formation after injury. The exact pathogenesis of HO remains unknown. Here we show that TGF-β initiates and promotes HO in mice. We find that calcified cartilage and newly formed bone resorb osteoclasts after onset of HO, which leads to high levels of active TGF-β that recruit mesenchymal stromal/progenitor cells (MSPCs) in the HO microenvironment. Transgenic expression of active TGF-β in tendon induces spontaneous HO, whereas systemic injection of a TGF-β neutralizing antibody attenuates ectopic bone formation in traumatic and BMP-induced mouse HO models, and in a fibrodysplasia ossificans progressive mouse model...
February 7, 2018: Nature Communications
https://www.readbyqxmd.com/read/29414810/knockdown-of-long-non-coding-rna-rp11-445h22-4-alleviates-lps-induced-injuries-by-regulation-of-mir-301a-in-osteoarthritis
#18
Taitao Sun, Jian Yu, Liang Han, Shuo Tian, Bin Xu, Xianbin Gong, Qiang Zhao, Yang Wang
BACKGROUND/AIMS: Several long non-coding RNAs (lncRNAs) play vital roles in osteoarthritis (OA), whereas the role of lncRNA RP11-445H22.4 in OA remains unclear. The study aimed to investigate the effect of lncRNA RP11-445H22.4 on lipopolysaccharide (LPS)-induced cell viability, apoptosis and inflammatory injury of OA. METHODS: The expression of RP11-445H22.4, miR-301a and CXCR4 in human cartilage ATDC5 cells were altered by transfection, and then cells were exposed to 5 µg/ml LPS for 12 h...
January 31, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29411714/effects-of-tissue-processing-on-bioactivity-of-cartilage-matrix-based-hydrogels-encapsulating-osteoconductive-particles
#19
Jakob M Townsend, Taylor A Zabel, Yi Feng, Jinxi Wang, Brian T Andrews, Randy Nudo, Cory Berkland, Michael S Detamore
In the treatment of severe traumatic brain injury (TBI), decompressive craniectomy is commonly used to remove a large portion of calvarial bone to allow unimpeded brain swelling. Hydrogels have the potential to revolutionize TBI treatment by permitting a single-surgical intervention, remaining pliable during brain swelling, and tuned to regenerate bone after swelling has subsided. With this motivation, our goal is to present a pliable material capable of regenerating calvarial bone across a critical size defect...
February 7, 2018: Biomedical Materials
https://www.readbyqxmd.com/read/29410585/extension-of-knee-immobilization-delays-recovery-of-histological-damages-in-the-anterior-cruciate-ligament-insertion-and-articular-cartilage-in-rabbits
#20
Hirotaka Mutsuzaki, Hiromi Nakajima, Masataka Sakane
[Purpose] To investigate the influence of knee immobilization period on recovery of histological damages in the anterior cruciate ligament (ACL) insertion and articular cartilage in rabbits. This knowledge is important for determining the appropriate rehabilitation approach for patients with ligament injuries, fracture, disuse atrophy, and degenerative joint disease. [Materials and Methods] Forty-eight male Japanese white rabbits were divided equally into the remobilization and control groups. The remobilization group had the right knee surgically immobilized, and was divided equally into four subgroups according to the duration of immobilization (1, 2, 4 and 8 weeks)...
January 2018: Journal of Physical Therapy Science
keyword
keyword
12524
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"