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Cartilage injuries

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https://www.readbyqxmd.com/read/29905059/-current-progress-of-laser-assisted-cartilage-reshaping-for-prominent-ear
#1
REVIEW
Fengfeng Guo, Xiaobo Yu, Haiyue Jiang
Objective: To summarize the current progress of laser-assisted cartilage reshaping (LACR) for prominent ear. Methods: The domestic and abroad article concerning the LACR in treatment of prominent ear was reviewed and analyzed. Results: As a new technique, there were three types of LACR therapies that been used for prominent ear. LACR with the 1 064 nm Nd/YAG laser is painful and the penetration depth of the 1 064 nm Nd/YAG laser is greater than that of the 1540 nm Er/Glass laser which is caused more tissue injury...
June 1, 2018: Chinese Journal of Reparative and Reconstructive Surgery
https://www.readbyqxmd.com/read/29904041/anti-vascular-endothelial-growth-factor-vegf-antibody-ameliorates-cartilage-degradation-in-a-rat-model-of-chronic-sports-arthritic-injury
#2
Lei Shang, Yong Xu, Changqing Shao, Chao Ma, Yanbo Feng
BACKGROUND Although a relationship between vascular endothelial growth factor (VEGF) and articular cartilage degeneration has been reported, little is known regarding its role in articular cartilage injury induced by sports activities. In this study, we evaluated the role of VEGF in a rat model of chronic sports arthritic injury. MATERIAL AND METHODS Animals were divided into 3 groups: Control (n=10), Vehicle (chronic sports arthritic injury, n=10), and Bevacizumab (chronic sports arthritic injury treated with anti-VEGF monoclonal antibody Bevacizumab, n=10)...
June 15, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29902525/propolis-extract-a-new-reinforcement-material-in-improving-bone-healing-an-in-vivo-study
#3
Abdolhamid Meimandi-Parizi, Ahmad Oryan, Emad Sayahi, Amin Bigham-Sadegh
BACKGROUND: propolis is known for its antioxidant, immune response modulating, and wound healing effects. In the present study in order to determine the bone healing capacity of the propolis extract, a critical sized, nonunion, radial bone defect model was repaired in rat, using chitosan and demineralized bone matrix (DBM) scaffolds along with propolis extract. MATERIALS AND METHODS: Seventy-two radial bone defects in 36 healthy male rats were randomly divided into 6 groups (n= 12/group)...
June 11, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29900170/the-stromal-vascular-fraction-from-fat-tissue-in-the-treatment-of-osteochondral-knee-defect-case-report
#4
Ramil Z Salikhov, Ruslan F Masgutov, Mikhail A Chekunov, Leysan G Tazetdinova, Galina Masgutova, Oleg V Teplov, Damir Galimov, Yuri Plakseichuk, Ramil Yagudin, Igor O Pankov, Albert Rizvanov
In this study we applied autologous fat tissue stromal vascular fraction (SVF) cells in combination with microfracturing technique in a 36-year-old man with an osteochondral lesion of the medial femoral condyle 8 months after the injury. Cell material was generated by fat tissue liposuction from the anterior abdominal wall with subsequent extraction of the SVF and injected through a mini-arthrotomy portal with subsequent fibrin sealant fixation. The follow-up period was 2 years. Clinical score improved from 23 to 96 according to IKDC and from 10 to 90 according to EQ-VAS at 24 months follow-up...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29892280/complement-in-the-initiation-and-evolution-of-rheumatoid-arthritis
#5
REVIEW
V Michael Holers, Nirmal K Banda
The complement system is a major component of the immune system and plays a central role in many protective immune processes, including circulating immune complex processing and clearance, recognition of foreign antigens, modulation of humoral and cellular immunity, removal of apoptotic and dead cells, and engagement of injury resolving and tissue regeneration processes. In stark contrast to these beneficial roles, however, inadequately controlled complement activation underlies the pathogenesis of human inflammatory and autoimmune diseases, including rheumatoid arthritis (RA) where the cartilage, bone, and synovium are targeted...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29887917/reasons-for-surgical-revision-after-conservatively-treated-radial-head-fractures-retrospective-study-of-70-patients
#6
R Nietschke, K J Burkhart, B Hollinger, F I Dehlinger, A Zimmerer, M M Schneider
Background: An inadequate clinical outcome after conservatively treated radial head fractures is not uncommon. We analyzed the subjective limitations, objective complaints, and surgical procedures for radial head fractures initially treated conservatively. Patients and method: Between 2007 and 2016, 70 patients (42 men, 28 women) who suffered from fracture sequelae after conservatively treated radial head fractures were examined. Demographic (age, 41.8 years, range, 16-75 years) and clinical data (pain, range of motion, instability) were retrospectively evaluated...
2018: Obere Extremität
https://www.readbyqxmd.com/read/29887623/calcaneal-fractures-should-we-or-should-we-not-operate
#7
Stefan Rammelt, Bruce J Sangeorzan, Michael P Swords
The best treatment for displaced, intraarticular fractures of the calcaneum remains controversial. Surgical treatment of these injuries is challenging and have a considerable learning curve. Studies comparing operative with nonoperative treatment including randomized trials and meta-analyses are fraught with a considerable number of confounders including highly variable fracture patterns, soft-tissue conditions, patient characteristics, surgeon experience, limited sensitivity of outcome measures, and rehabilitation protocols...
May 2018: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/29886166/attenuation-of-the-degenerative-effects-of-endothelin-1-on-cartilaginous-endplate-cells-by-the-endothelin-receptor-antagonist-bq-123-via-the-wnt-%C3%AE-catenin-signaling-pathway
#8
Wei Yuan, Zhen-Xi Li, Cheng-Long Zhao, Tian-Hui Hou, Si-Wang Hu, Wei-Bo Liu, Feng-Lai Yuan, Jian-Ru Xiao
BACKGROUND: Context: Endothelin-1 (ET-1) is an inflammatory mediator associated with cartilage endplate (CEP) degeneration in the intervertebral disc. SOX9 is down-regulated during CEP degeneration, along with its targets, collagen II and aggrecan. Wnt/β-catenin signaling is associated with CEP degeneration and a downstream target of SOX9; however, the precise mechanism of CEP degeneration and the role of ET-1 are largely unknown. PURPOSE: The purpose of the study was to evaluate the influence of the endothelin A receptor antagonist, BQ-123, on ET-1-induced effects on cartilaginous endplate cells (CECs) associated with CEP degeneration via the Wnt/β-catenin signaling pathway...
June 7, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29884210/pannus-inflammation-in-sacroiliitis-following-immune-pathological-injury-and-radiological-structural-damage-a-study-of-193-patients-with-spondyloarthritis
#9
Dan Min Wang, Ling Lin, Jian Hua Peng, Yao Gong, Zhi Duo Hou, Su Biao Chen, Zheng Yu Xiao
BACKGROUND: The pathogenesis of sacroiliitis is unclear; therefore, we aimed to systematically study the immunopathology of sacroiliitis in patients with axial spondyloarthritis (axSpA), and explore the relationship between pannus formation, inflammation, and the structural damage caused by sacroiliitis. METHODS: Fine needle aspiration biopsy of the sacroiliac joint (SIJ) was performed in 193 patients with axSpA. Clinical, laboratory, and imaging data were collected at baseline and during the follow up...
June 8, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29883506/use-of-a-core-reamer-for-the-resection-of-a-central-distal-femoral-physeal-bone-bridge-a-novel-technique-with-3-year-follow-up
#10
Zachary K Pharr, Joan D Roaten, Alice Moisan, Derek M Kelly, Jeffrey R Sawyer
A central distal femoral physeal bone bridge in a boy aged 5 years and 7 months was resected with a fluoroscopically guided core reamer placed through a lateral parapatellar approach. At 3-year follow-up, the boy's leg-length discrepancy was 3.0 cm (3.9 cm preoperatively), and the physeal bone bridge did not recur. The patient had full function and no pain or other patellofemoral complaints. This technique provided direct access to the physeal bone bridge, and complete resection was performed without injury to the adjacent physeal cartilage in the medial and lateral columns of the distal femur, which is expected to grow normally in the absence of the bridge...
May 2018: American Journal of Orthopedics
https://www.readbyqxmd.com/read/29881886/greater-magnitude-tibiofemoral-contact-forces-are-associated-with-reduced-prevalence-of-osteochondral-pathologies-2-3-years-following-anterior-cruciate-ligament-reconstruction
#11
David John Saxby, Adam L Bryant, Ans Van Ginckel, Yuanyuan Wang, Xinyang Wang, Luca Modenese, Pauline Gerus, Jason M Konrath, Karine Fortin, Tim V Wrigley, Kim L Bennell, Flavia M Cicuttini, Christopher Vertullo, Julian A Feller, Tim Whitehead, Price Gallie, David G Lloyd
PURPOSE: External loading of osteoarthritic and healthy knees correlates with current and future osteochondral tissue state. These relationships have not been examined following anterior cruciate ligament reconstruction. We hypothesised greater magnitude tibiofemoral contact forces were related to increased prevalence of osteochondral pathologies, and these relationships were exacerbated by concomitant meniscal injury. METHODS: This was a cross-sectional study of 100 individuals (29...
June 7, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29878401/inhibition-of-bromodomain-containing-protein-4-ameliorates-oxidative-stress-mediated-apoptosis-and-cartilage-matrix-degeneration-through-activation-of-nf-e2-related-factor-2-heme-oxygenase-1-signaling-in-rat-chondrocytes
#12
Qin-de An, Yun-Yun Li, Hong-Xing Zhang, Jun Lu, Xiao-Dong Yu, Qiang Lin, Yin-Gang Zhang
During the progression of osteoarthritis, dysregulation of extracellular matrix (ECM) anabolism, abnormal generation of reactive oxygen species, and proteolytic enzymes have been shown to accelerate the degradation process of cartilage. The purpose of the current study was to investigate the functional role of bromodomain-containing protein 4 (BRD4) in hydrogen peroxide (H2 O2 )-stimulated chondrocyte injury and delineate the underlying molecular mechanisms. We observed that the expression BRD4 was markedly elevated in rat chondrocytes after H2 O2 stimulation...
June 7, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29876862/earlier-anterior-cruciate-ligament-reconstruction-is-associated-with-a-decreased-risk-of-medial-meniscal-and-articular-cartilage-damage-in-children-and-adolescents-a-systematic-review-and-meta-analysis
#13
REVIEW
Jeffrey Kay, Muzammil Memon, Ajay Shah, Yi-Meng Yen, Kristian Samuelsson, Devin Peterson, Nicole Simunovic, Helene Flageole, Olufemi R Ayeni
PURPOSE: To evaluate the association between surgical timing and the incidence of secondary meniscal or chondral damage in children and adolescents with anterior cruciate ligament (ACL) ruptures. METHODS: Three electronic databases, PubMed, MEDLINE, and EMBASE, were systematically searched from database inception until October 16, 2017 by two reviewers independently and in duplicate. The inclusion criteria were English language studies that reported the incidence of meniscal and articular cartilage damage in children or adolescent athletes with ACL injuries as well as the timing of their ACL reconstruction (ACLR)...
June 6, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29876497/neglected-semimembranosus-osteochondral-avulsion-fracture-of-the-posteromedial-tibial-plateau
#14
Rakesh John, Devendra K Chouhan, Mandeep Singh Dhillon
Semimembranosus avulsion fracture is infrequently reported and is easy to miss on plain radiographs; the mechanism of injury is highly controversial. Initial reports linked it to anterior cruciate ligament and medial meniscal tears. We report an osteochondral semimembranosus avulsion fracture of the posteromedial tibial plateau with associated posterior cruciate ligament rupture. Also described is a novel surgical fixation technique for such osteochondral fractures where the surgical exposure is limited due to the obliquity of the fracture line resulting in a greater involvement of the articular cartilage than the small bony component...
June 2018: Trauma Case Reports
https://www.readbyqxmd.com/read/29869683/bone-bruise-in-anterior-cruciate-ligament-rupture-entails-a-more-severe-joint-damage-affecting-joint-degenerative-progression
#15
REVIEW
Giuseppe Filardo, Luca Andriolo, Giorgio di Laura Frattura, Francesca Napoli, Stefano Zaffagnini, Christian Candrian
PURPOSE: During anterior cruciate ligament (ACL) injury, the large external forces responsible for ligament rupture cause a violent impact between tibial and femoral articular cartilage, which is transferred to bone resulting in bone bruise detectable at MRI. Several aspects remain controversial and await evidence on how this MRI finding should be managed while addressing the ligament lesion. Thus, the aim of the present review was to document the evidence of all available literature on the role of bone bruise associated with ACL lesions...
June 5, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29868434/arthroscopic-medial-meniscus-root-repair-with-soft-suture-anchor-without-posterior-portal-technique
#16
Somsak Kuptniratsaikul, Thun Itthipanichpong, Vanasiri Kuptniratsaikul
Medial meniscal root injury is known to cause an increase in tibiofemoral contact pressure and results in early osteoarthritis. There have been many reports on meniscal root repairing techniques, which can be categorized into 2 groups. One is transosseous suture, and the other is anchor suture repair. Both techniques show improvement in not only clinical performance, but also radiographic finding. However, the meniscal root repair procedure must be performed by experienced physicians. Most techniques require a posteromedial portal, which takes time and may even complicate the procedure...
May 2018: Arthroscopy Techniques
https://www.readbyqxmd.com/read/29868410/bone-marrow-aspirate-concentrate-and-microfracture-technique-for-talar-osteochondral-lesions-of-the-ankle
#17
Evelyn P Murphy, Christopher Fenelon, Niall P McGoldrick, Stephen R Kearns
Osteochondral lesions of the talus refer to a chondral or subchondral defect of the articular cartilage and potentially the underlying bone. Ankle sprains are an extremely common injury; approximately 27,000 ankle sprains occur per day in America. Fifty percent of these can lead to a cartilage injury to the ankle. There has been a high quoted rate of failure with conservative measures of up to 45% in some series. Surgical options are largely broken down into 2 groups, namely, reparative or regenerative treatments...
April 2018: Arthroscopy Techniques
https://www.readbyqxmd.com/read/29867124/comp-prohibitin-2-interaction-maintains-mitochondrial-homeostasis-and-controls-smooth-muscle-cell-identity
#18
Yiting Jia, Meili Wang, Chenfeng Mao, Fang Yu, Yingbao Wang, Rui Xiao, Changtao Jiang, Lemin Zheng, Qingbo Xu, Ming Zheng, Yi Fu, Qinghua Hu, Wei Kong
Vascular smooth muscle cells (VSMCs) are highly phenotypically plastic, and loss of the contractile phenotype in VSMCs has been recognized at the early onset of the pathology of a variety of vascular diseases. However, the endogenous regulatory mechanism to maintain contractile phenotype in VSMCs remains elusive. Moreover, little has been known about the role of the mitochondrial bioenergetics in terms of VSMC homeostasis. Herein, we asked if glycoprotein COMP (Cartilage oligomeric matrix protein) is involved in mitochondrial bioenergetics and therefore regulates VSMCs homeostasis...
June 4, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29865924/poor-outcome-after-a-surgically-treated-chondral-injury-on-the-medial-femoral-condyle-early-evaluation-with-dgemric-and-17-year-radiographic-and-clinical-follow-up-in-16-knees
#19
Jon Tjörnstrand, Paul Neuman, Björn Lundin, Jonas Svensson, Leif E Dahlberg, Carl Johan Tiderius
Background and purpose - The optimal treatment for traumatic cartilage injuries remains unknown. Contrast-enhanced MRI of cartilage (dGEMRIC) evaluates cartilage quality and a low dGEMRIC index may predict radiographic osteoarthritis (OA). The purpose of this study was (a) to explore the results 17 years after surgical treatment of an isolated cartilage knee injury and (b) to evaluate the predictive value of dGEMRIC. Patients and methods - 16 knees with an isolated traumatic cartilage injury of the medial femoral condyle had cartilage repair surgery either by microfracture or autologous cartilage implantation...
June 5, 2018: Acta Orthopaedica
https://www.readbyqxmd.com/read/29861739/evaluation-of-the-curative-effect-of-umbilical-cord-mesenchymal-stem-cell-therapy-for-knee-arthritis-in-dogs-using-imaging-technology
#20
Bei-Ying Zhang, Bing-Yun Wang, Shao-Chuan Li, Dong-Zhang Luo, Xiaoshu Zhan, Sheng-Feng Chen, Zhi-Sheng Chen, Can-Ying Liu, Hui-Qin Ji, Yin-Shan Bai, Dong-Sheng Li, Yang He
Objective: The aim of this study was to assess the efficacy of canine umbilical cord mesenchymal stem cells (UC-MSCs) on the treatment of knee osteoarthritis in dogs. Methods: Eight dogs were evenly assigned to two groups. The canine model of knee osteoarthritis was established by surgical manipulation of knee articular cartilage on these eight dogs. UC-MSCs were isolated from umbilical cord Wharton's jelly by 0.1% type collagenase I and identified by immunofluorescence staining and adipogenic and osteogenic differentiation in vitro ...
2018: Stem Cells International
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