Maddie Hasson, Lorenzo M Fernandes, Hanna Solomon, Tristan Pepper, Nicholas L Huffman, Saitheja A Pucha, Jason T Bariteau, Jarred M Kaiser, Jay M Patel
BACKGROUND: Marrow stimulation is a common reparative approach to treat injuries to cartilage and other soft tissues (e.g., rotator cuff). It involves the recruitment of bone marrow elements and mesenchymal stem cells (MSCs) into the defect, theoretically initiating a regenerative process. However, the resulting repair tissue is often weak and susceptible to deterioration with time. The populations of cells at the marrow stimulation site (beyond MSCs), and their contribution to inflammation, vascularity, and fibrosis, may play a role in quality of the repair tissue...
April 10, 2024: Cells, Tissues, Organs