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https://www.readbyqxmd.com/read/29051901/fresh-osteochondral-allograft-transplantation-for-spontaneous-osteonecrosis-of-the-knee-a-case-series
#1
Luís E P Tírico, Samuel A Early, Julie C McCauley, William D Bugbee
BACKGROUND: Spontaneous osteonecrosis of the knee (SONK) is a clinical entity identified by acute knee pain usually associated with joint effusion, with radiographic findings of a radiolucent defect on the weightbearing area of the femoral condyle. Conservative treatment is initially undertaken; however, surgical procedures are often necessary. Historically, surgical options have included core decompression, cartilage repair, high tibial osteotomy, or joint arthroplasty. Few studies in the literature have reported the use of fresh osteochondral allograft (OCA) for the treatment of SONK lesions...
October 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29050090/-laryngotracheal-resection-and-reconstruction-for-the-treatment-of-acquired-laryngotracheal-stenosis
#2
L J Ma, Y Xiao, Q W Yang, J Wang
Objective: To analyze the efficacy of laryngotracheal resection and reconstruction for acquired laryngotracheal stenosis, and to discuss the prevention of complication. Methods: The clinical outcomes of seventy patients with acquired laryngotracheal stenosis, treated with laryngotracheal resection and reconstruction were retrospectively reviewed between January 2007 and December 2016. The degree of stenosis was classified according to Myer-Cotton classification as follows: grade Ⅱ(n=7), grade Ⅲ(n=38) and grade Ⅳ(n=27)...
October 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/29047310/reserve-or-resident-progenitors-in-cartilage-comparative-analysis-of-chondrocytes-versus-chondroprogenitors-and-their-role-in-cartilage-repair
#3
Elizabeth Vinod, P R J V C Boopalan, Solomon Sathishkumar
Introduction Articular cartilage is made up of hyaline tissue embodying chondrocytes, which arise from mesenchymal stromal cells (MSCs) and specialized extracellular matrix. Despite possessing resident progenitors in and around the joint primed for chondrogenesis, cartilage has limited intrinsic capacity of repair and cell turnover. Advances in isolation, culture, and characterization of these progenitors have raised the possibility for their use in cell-based cartilage repair. Chondroprogenitors (CPCs) have been classified as MSCs and have been postulated to play a vital role in injury response and are identified by their colony forming ability, proliferative potential, telomere dynamics, multipotency, and expression of stem cell markers...
October 1, 2017: Cartilage
https://www.readbyqxmd.com/read/29044705/subchondral-trabecular-rod-loss-and-plate-thickening-in-the-development-of-osteoarthritis
#4
Yan Chen, Yizhong Hu, Y Eric Yu, Xingjian Zhang, Tezita Watts, Bin Zhou, Ji Wang, Ting Wang, Weiwei Zhao, Kwong Yuen Chiu, Frankie K L Leung, Xu Cao, William W Lu, William Macaulay, Kyle K Nishiyama, Elizabeth Shane, X Edward Guo
Developing effective treatment for osteoarthritis (OA), a prevalent and disabling disease, has remained a challenge, primarily due to limited understanding of its pathogenesis and late diagnosis. In the subchondral bone, rapid bone loss following traumatic injuries and bone sclerosis at the advanced stage of OA are well-recognized hallmarks of the disease. Recent studies have further demonstrated the crucial contribution of subchondral bone in the development of OA. However, the microstructural basis of these bone changes has not been examined thoroughly, and the paradox of how abnormal resorption can eventually lead to bone sclerosis remains unanswered...
October 17, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29031137/the-association-between-habitual-walking-speed-and-medial-femoral-cartilage-deformation-following-30minutes-of-walking
#5
Matthew S Harkey, J Troy Blackburn, Hope Davis, Leslie Sierra-Arévalo, Daniel Nissman, Brian Pietrosimone
Habitual walking speed is a key functional outcome that has implications for knee biomechanics that occur during gait. Lower extremity biomechanics during walking affects the loading of the femoral cartilage. Ultrasonography (US) can be used to assess resting femoral cartilage thickness and acute cartilage deformation in response to walking. The purpose of this study was to determine the association between habitual walking speed and both resting femoral cartilage thickness and deformation. Twenty-four healthy participants with no history of knee injury volunteered for this study...
October 7, 2017: Gait & Posture
https://www.readbyqxmd.com/read/29028449/geometric-characteristics-of-the-knee-are-associated-with-a-noncontact-acl-injury-to-the-contralateral-knee-after-unilateral-acl-injury-in-young-female-athletes
#6
James G Levins, Erin C Argentieri, Daniel R Sturnick, Mack Gardner-Morse, Pamela M Vacek, Timothy W Tourville, Robert J Johnson, James R Slauterbeck, Bruce D Beynnon
BACKGROUND: Contralateral anterior cruciate ligament (CACL) injury after recovery from a first-time ACL rupture occurs at a high rate in young females; however, little is known about the risk factors associated with bilateral ACL trauma. HYPOTHESIS: The geometric characteristics of the contralateral knee at the time of the initial ACL injury are associated with risk of suffering a CACL injury in these female athletes. STUDY DESIGN: Case-control study; Level of evidence, 3...
October 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29024597/significant-chondrocyte-viability-is-present-in-acetabular-chondral-flaps-associated-with-femoroacetabular-impingement
#7
Vonda J Wright, Christopher Laurence McCrum, Hongshuai Li, Michael J Tranovich, Johnny Huard
BACKGROUND: Patients presenting with cam deformity of the femoral head and neck sustain repeated trauma to the articular cartilage of the superior acetabulum, with chondral delamination injuries found during hip arthroscopy. Two previous studies reveal conflicting chondrocyte viability data in these traumatic cartilage injuries. The full-thickness nature of flaps may suggest that chondrocytes residing in the cartilage flap matrix in the joint environment would remain viable despite shear trauma...
October 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29022912/tenomodulin-is-essential-for-prevention-of-adipocyte-accumulation-and-fibrovascular-scar-formation-during-early-tendon-healing
#8
Dasheng Lin, Paolo Alberton, Manuel Delgado Caceres, Elias Volkmer, Matthias Schieker, Denitsa Docheva
Tenomodulin (Tnmd) is the best-known mature marker for tendon and ligament lineage cells. It is important for tendon maturation, running performance and has key implications for the resident tendon stem/progenitor cells (TSPCs). However, its exact functions during the tendon repair process still remain elusive. Here, we established an Achilles tendon injury model in a Tnmd knockout (Tnmd(-/-)) mouse line. Detailed analyses showed not only a very different scar organization with a clearly reduced cell proliferation and expression of certain tendon-related genes, but also increased cell apoptosis, adipocyte and blood vessel accumulation in the early phase of tendon healing compared with their wild-type (WT) littermates...
October 12, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29020891/biologic-joint-repair-strategies-the-mizzou-biojoint-story
#9
Keiichi Kuroki, Aaron M Stoker, James P Stannard, Chantelle C Bozynski, Cristi R Cook, Ferris M Pfeiffer, James L Cook
Because articular cartilage has very limited healing potential, most symptomatic cartilage injuries eventually result in end-stage osteoarthritis and are treated with artificial joint replacement. Our interdisciplinary, comparative orthopedic research performed by a team of DVMs, MDs, engineers, and basic scientists has yielded marked progress toward effective biologic joint restoration strategies by bringing bench-side ideas to fruition in bedside applications in both canine and human patients. This mini-review summarizes the progress of biologic joint restoration strategies at our center...
January 1, 2017: Toxicologic Pathology
https://www.readbyqxmd.com/read/28989937/comparison-of-2-radiographic-techniques-for-measurement-of-tibiofemoral-joint-space-width
#10
Nabil Mehta, Jeffrey Duryea, Gary J Badger, Matthew R Akelman, Morgan H Jones, Kurt P Spindler, Braden C Fleming
BACKGROUND: No consensus is available regarding the best method for measuring tibiofemoral joint space width (JSW) on radiographs to quantify joint changes after injury. Studies that track articular cartilage thickness after injury frequently use patients' uninjured contralateral knees as controls, although the literature supporting this comparison is limited. PURPOSE: (1) To compare JSW measurements using 2 established measurement techniques in healthy control participants and (2) to determine whether the mean JSW of the uninjured contralateral knee in a cohort with anterior cruciate ligament (ACL) reconstruction is different from that obtained from a true control population...
September 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28989151/-application-of-pie-crusting-the-medial-collateral-ligament-release-in-arthroscopic-surgery-for-posterior-horn-of-%C3%A2-medial-meniscus-in-knee-joint
#11
Weihong Zhu, Qi Tang, Lele Liao, Ding Li, Yang Yang, You Chen
To explore the effectiveness and safety of pie-crusting the medial collateral ligament release (MCL) in treating posterior horn of medial meniscus (PHMM) tear in tight medial tibiofemoral compartment of knee joint.
 Methods: Thirty-two consecutive patients with PHMM tear in tight medial tibiofemoral compartment of knee joint were admitted to our department from January, 2013 to December, 2014. All patients were performed pie-crusting the MCL release at its tibial insertion with 18-gauge intravenous needle...
September 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28988443/effects-of-supramaximal-balloon-dilatation-pressures-on-adult-cricoid-and-tracheal-cartilage-a-cadaveric-study
#12
Venkata S P B Durvasula, Sara C Shalin, Ozlem E Tulunay-Ugur, James Y Suen, Gresham T Richter
OBJECTIVES/HYPOTHESIS: Cricoid fracture is a serious concern for balloon dilatation in airway stenosis. Furthermore, there are no studies examining tracheal rupture in balloon dilatation of stenotic segments. The aim of this study was to evaluate the effect of supramaximal pressures of balloons on the cricoid and tracheal rings. STUDY DESIGN: Prospective cadaveric study. METHODS: Seven cadaveric laryngotracheal complexes of normal adults with intact cricothyroid membranes were acquired...
October 8, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28987873/hip-joint-biomechanics-in-those-with-and-without-post-traumatic-knee-osteoarthritis-after-anterior-cruciate-ligament-injury
#13
E Wellsandt, J A Zeni, M J Axe, L Snyder-Mackler
BACKGROUND: Anterior cruciate ligament injury results in altered kinematics and kinetics in the knee and hip joints that persist despite surgical reconstruction and rehabilitation. Abnormal movement patterns and a history of osteoarthritis are risk factors for articular cartilage degeneration in additional joints. The purpose of this study was to determine if hip joint biomechanics early after anterior cruciate ligament injury and reconstruction differ between patients with and without post-traumatic knee osteoarthritis 5years after reconstruction...
October 2, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28985125/progressive-changes-in-walking-kinematics-and-kinetics-after-anterior-cruciate-ligament-injury-and-reconstruction-a-review-and-meta-analysis
#14
Lindsay V Slater, Joseph M Hart, Adam R Kelly, Christopher M Kuenze
CONTEXT:   Anterior cruciate ligament (ACL) injury and ACL reconstruction (ACLR) result in persistent alterations in lower extremity movement patterns. The progression of lower extremity biomechanics from the time of injury has not been described. OBJECTIVE:   To compare the 3-dimensional (3D) lower extremity kinematics and kinetics of walking among individuals with ACL deficiency (ACLD), individuals with ACLR, and healthy control participants from 3 to 64 months after ACLR...
September 2017: Journal of Athletic Training
https://www.readbyqxmd.com/read/28984733/cartilage-endplate-thickness-variation-measured-by-ultrashort-echo-time-mri-is-associated-with-adjacent-disc-degeneration
#15
Britta Berg-Johansen, Misung Han, Aaron J Fields, Ellen C Liebenberg, Brandon J Lim, Peder Ez Larson, Cigdem Gunduz-Demir, Galateia J Kazakia, Roland Krug, Jeffrey C Lotz
STUDY DESIGN: A magnetic resonance imaging study of human cadaver spines. OBJECTIVE: To investigate associations between cartilage endplate (CEP) thickness and disc degeneration. SUMMARY OF BACKGROUND DATA: Damage to the CEP is associated with spinal injury and back pain. However, CEP morphology and its association with disc degeneration have not been well characterized. METHODS: Ten lumbar motion segments with varying degrees of disc degeneration were harvested from six cadaveric spines and scanned with MRI in the sagittal plane using a T2-weighted 2D sequence, a 3D ultrashort echo-time (UTE) imaging sequence, and a 3D T1ρ mapping sequence...
October 3, 2017: Spine
https://www.readbyqxmd.com/read/28982790/basion-cartilaginous-dens-interval-an-imaging-parameter-for-craniovertebral-junction-assessment-in-children
#16
A K Singh, Z Fulton, R Tiwari, X Zhang, L Lu, W B Altmeyer, B Tantiwongkosi
BACKGROUND AND PURPOSE: Widening of the basion-dens interval is an important sign of cranioverterbral junction injury. The current literature on basion-dens interval in children is sparse and based on bony measurements with variable values. Our goal was to establish the normal values of a recently described new imaging parameter, the basion-cartilaginous dens interval in children. MATERIALS AND METHODS: Three hundred healthy pediatric patients (0-10 years of age) were selected retrospectively...
October 5, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28981117/trehalose-ameliorates-oxidative-stress-mediated-mitochondrial-dysfunction-and-er-stress-via-selective-autophagy-stimulation-and-autophagic-flux-restoration-in-osteoarthritis-development
#17
Qian Tang, Gang Zheng, Zhenhua Feng, Yu Chen, Yiting Lou, Chenggui Wang, Xiaolei Zhang, Yu Zhang, Huazi Xu, Ping Shang, Haixiao Liu
Oxidative stress-related apoptosis and autophagy play crucial roles in the development of osteoarthritis (OA), a progressive cartilage degenerative disease with multifactorial etiologies. Here, we determined autophagic flux changes and apoptosis in human OA and tert-Butyl hydroperoxide (TBHP)-treated chondrocytes. In addition, we explored the potential protective effects of trehalose, a novel Mammalian Target of Rapamycin (mTOR)-independent autophagic inducer, in TBHP-treated mouse chondrocytes and a destabilized medial meniscus (DMM) mouse OA model...
October 5, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28980547/-the-age-specific-changes-in-the-histological-structure-of-the-thyroid-cartilage-in-the-men
#18
Yu I Pigolkin, M P Poletaeva, G V Zolotenkova, A V Volkov
The objective of the present study was to elucidate the morphological and morphometric characteristics of the human thyroid cartilage during different periods of life. The thyroid cartilages were harvested from 70 cadavers of the subjects of the masculine gender who had died at the age from 1 to 93 years from the non-violent causes and had neither injuries nor signs of pathological changes in the neck organs. The microscopic studies were carried out using the standard methods for the staining of the preparations with hematoxylin and eosin...
2017: Sudebno-meditsinskaia Ekspertiza
https://www.readbyqxmd.com/read/28979596/treatment-of-the-posterior-unstable-shoulder
#19
Eduardo Sánchez Alepuz, Jaime Alonso Pérez-Barquero, Nadia Jover Jorge, Francisco Lucas García, Vicente Carratalá Baixauli
BACKGROUND: It is estimated that approximately 5% of glenohumeral instabilities are posterior. There are a number of controversies regarding therapeutic approaches for these patients. METHODS: We analyse the main surgery alternatives for the treatment of the posterior shoulder instability. We did a research of the publications related with posterior glenohumeral instability. RESULTS: There are conservative and surgical treatment options. Conservative treatment has positive results in most patients, with around 65 to 80% of cases showing recurrent posterior dislocation...
2017: Open Orthopaedics Journal
https://www.readbyqxmd.com/read/28979588/management-of-osteochondral-lesions-of-the-talar-dome
#20
Chamnanni Rungprai, Joshua N Tennant, Ryan D Gentry, Phinit Phisitkul
Osteochondral lesion of the talus (OLT) is a common condition associated with ankle injury that brings challenges in the diagnosis and treatment. Symptoms related to this condition are nonspecific including pain, swelling, stiffness, and mechanical symptoms of locking and catching. While the natural history of the OLTs is not well understood, surgical treatment is often required especially in chronic cases and acute cases with displaced articular fragments. Arthroscopic treatment of the OLTs aims to restore ankle joint function and pain relief by the removal of the chondral or osteochondral fragment, debridement and stabilization of cartilage rim and subchondral bone, and stimulate healing of the bone and damaged cartilage...
2017: Open Orthopaedics Journal
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