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Cartilage injuries

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https://www.readbyqxmd.com/read/29678623/differences-in-subchondral-bone-plate-and-cartilage-thickness-between-women-with-anterior-cruciate-ligament-reconstructions-and-uninjured-controls
#1
Jennifer L Bhatla, Andres Kroker, Sarah L Manske, Carolyn A Emery, Steven K Boyd
OBJECTIVE: Anterior cruciate ligament (ACL) tears increase early onset osteoarthritis (OA) risk leading to cartilage and bone degradation. While the contribution of bone in OA development is unclear, evidence suggests that bone changes accompany cartilage degradation. This study aims to assess if regions with differences in subchondral bone plate thickness have differences in cartilage thickness when comparing ACL reconstructed (ACLR) knees of women ≥5 years post-injury to contralateral and controls with uninjured knees...
April 17, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29673544/no-effect-of-creatine-monohydrate-supplementation-on-inflammatory-and-cartilage-degradation-biomarkers-in-individuals-with-knee-osteoarthritis
#2
Stephen M Cornish, Jason D Peeler
The study purpose was to evaluate the effectiveness of creatine monohydrate supplementation (20 grams/day for 1 week and then 5 grams/day for 11 weeks) on inflammation (C-reactive protein, interleukin-1β, interleukin-6, s100 A8/A9, and tumor necrosis factor-α) and cartilage degradation (serum cartilage oligomeric matrix protein) in patients with knee osteoarthritis. We hypothesized that supplementing with creatine monohydrate for 12 weeks would lower biomarkers of inflammation and cartilage degradation in patients with knee osteoarthritis when compared to placebo...
March 2018: Nutrition Research
https://www.readbyqxmd.com/read/29672434/assessment-of-cartilage-growth-after-biopsy-of-osteochondral-loose-bodies-in-adolescent-knees-for-use-in-autologous-chondrocyte-implantation
#3
Sean Robinson, Jonathan Kramer, Trevor Shelton, Jarrad Merriman, Brian Haus
BACKGROUND: The goal of this study is to determine whether harvested cartilage from an osteochondral loose body maintains the same viability for implantation as cartilage harvested from the traditional locations within the adolescent knee for autologous chondrocyte implantation (ACI). METHODS: A retrospective study was performed on all ACI procedures performed from 2014 to 2017 at a single institution. Biopsies were derived from 2 groups: osteochondral loose body verses the intercondylar notch...
April 18, 2018: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/29669300/gzmb-gene-silencing-confers-protection-against-synovial-tissue-hyperplasia-and-articular-cartilage-tissue-injury-in-rheumatoid-arthritis-through-the-mapk-signaling-pathway
#4
Cui-Xia Bao, Hai-Xia Chen, Xue-Jie Mou, Xiang-Kui Zhu, Qi Zhao, Xin-Guang Wang
INTRODUCTION: Rheumatoid arthritis (RA) represents the most commonly occurring inflammatory type of arthritis and is a major cause of disability. Reports have placed emphasis on the potential of, granzyme B (GZMB) as a potentially valuable prognostic marker in early RA, the mechanism of which still remains largely unclear. Thus, the aim of the current study was to investigate the effects GZMB gene silencing influences synovial tissue hyperplasia and articular cartilage tissue injury of RA through the regulation of the MAPK signaling pathway...
April 15, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29667733/longitudinal-analysis-of-tibiofemoral-cartilage-contact-area-and-position-in-acl-reconstructed-patients
#5
Ellison Chen, Keiko Amano, Valentina Pedoia, Richard B Souza, C Benjamin Ma, Xiaojuan Li
Patients who have suffered ACL injury are more likely to develop early onset post-traumatic osteoarthritis despite reconstruction. The purpose of our study was to evaluate the longitudinal changes in the tibiofemoral cartilage contact area size and location after ACL injury and reconstruction. Thirty-one patients with isolated unilateral ACL injury were followed with T2 weighted Fast Spin Echo, T1ρ and T2 MRI at baseline prior to reconstruction, and 6 months, 1 year, and 2 years after surgery. Areas were delineated in FSE images with an in-house Matlab program using a spline-based semi-automated segmentation algorithm...
April 18, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29665801/an-extended-opensim-knee-model-for-analysis-of-strains-of-connective-tissues
#6
M Marieswaran, Arnab Sikidar, Anu Goel, Deepak Joshi, Dinesh Kalyanasundaram
BACKGROUND: OpenSim musculoskeletal models provide an accurate simulation environment that eases limitations of in vivo and in vitro studies. In this work, a biomechanical knee model was formulated with femoral articular cartilages and menisci along with 25 connective tissue bundles representing ligaments and capsules. The strain patterns of the connective tissues in the presence of femoral articular cartilage and menisci in the OpenSim knee model was probed in a first of its kind study...
April 17, 2018: Biomedical Engineering Online
https://www.readbyqxmd.com/read/29665604/-foreign-material-free-anterior-cruciate-ligament-repair-with-hamstring-graft-felmet-technique
#7
Marc Chmielnicki, Wolfram Siebert, Axel Prokop
Rupture of the anterior cruciate ligament (ACL) is a common sports injury. Shear forces can damage the articular cartilage and lead to early osteoarthritis. Ligamentary stabilisation of the knee is necessary. Today, arthroscopic ACL repair is a standard knee procedure. Transplant fixation is often performed using implants, e.g. interference screws. The foreign material-free procedure using the Felmet technique enables biological, mechanically stable fixation of the hamstring tendon graft. We demonstrate the surgical technique, including meniscus suture and a video case study...
April 2018: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/29663898/electrospun-fibers-for-cartilage-tissue-regeneration
#8
Guo Li, Sirong Shi, Shiyu Lin, Tengfei Zhou, Xiaoru Shao, Qiao Huang, Bofeng Zhu, Xiaoxiao Cai
BACKGROUND: Due to its poor self-repair ability, the cartilage injury has been a great challenge in clinical work. OBJECTIVE: The conventional therapies for cartilage injury mostly form fibrocartilage with weaker strength and flexibility compared to natural cartilage. The development of tissue engineering technology provides a new approach for cartilage repair and regeneration. RESULTS: An appropriate scaffold is one of key factors in cartilage tissue engineering...
April 17, 2018: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29662913/high-rate-of-missed-lateral-meniscus-posterior-root-tears-on-preoperative-magnetic-resonance-imaging
#9
Aaron J Krych, Isabella T Wu, Vishal S Desai, Naveen S Murthy, Mark S Collins, Daniel B F Saris, Bruce A Levy, Michael J Stuart
Background: Lateral meniscus posterior root tears (LMPRTs), if left untreated, can cause devastating effects to the knee, with rapid articular cartilage degeneration and loss of the meniscus as a secondary stabilizer. Detection and surgical repair of these defects have been linked to favorable outcomes, but preoperative identification of LMPRTs continues to be challenging. Purpose: To determine the rate of LMPRTs diagnosed preoperatively on magnetic resonance imaging (MRI) in a consecutive series of arthroscopically confirmed LMPRTs...
April 2018: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29662912/relationship-between-quantitative-mri-biomarkers-and-patient-reported-outcome-measures-after-cartilage-repair-surgery-a-systematic-review
#10
REVIEW
Drew A Lansdown, Kevin Wang, Eric Cotter, Annabelle Davey, Brian J Cole
Background: Treatment of articular cartilage injuries remains a clinical challenge, and the optimal tools to monitor and predict clinical outcomes are unclear. Quantitative magnetic resonance imaging (qMRI) allows for a noninvasive biochemical evaluation of cartilage and may offer advantages in monitoring outcomes after cartilage repair surgery. Hypothesis: qMRI sequences will correlate with early pain and functional measures. Study Design: Systematic review; Level of evidence, 3...
April 2018: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29659299/low-1-year-return-to-sport-rate-after-anterior-cruciate-ligament-reconstruction-regardless-of-patient-and-surgical-factors-a-prospective-cohort-study-of-272-patients
#11
Eric Hamrin Senorski, Eleonor Svantesson, Susanne Beischer, Christoffer Thomeé, Roland Thomeé, Jón Karlsson, Kristian Samuelsson
BACKGROUND: There is insufficient knowledge about the way that concomitant injuries affect the short-term likelihood of a return to a knee-strenuous sport after anterior cruciate ligament (ACL) reconstruction. Hypotheses/Purpose: The purpose was to study whether patient characteristics, concomitant injuries, and graft choice at primary ACL reconstruction can predict return to sport (RTS) 1 year after surgery. The hypotheses were that younger age at the time of ACL reconstruction would positively affect RTS, while the presence of concomitant injuries would negatively affect RTS 1 year after surgery...
April 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29658534/the-influence-of-osteoporotic-bone-structures-of-the-pelvic-hip-complex-on-stress-distribution-under-impact-load
#12
Katarzyna Arkusz, Tomasz Klekiel, Niezgoda Niezgoda, Romuald Będziński
PURPOSE: The aim of this study was to determine the effect of bone mineral density (BMD) on the stress distribution in pelvic-hip complex (PHC) model which included bone structures and soft tissues. Bone mass changes in osteoporosis and osteopenia were considered in this analysis. In addition, the relations between force direction and stress distribution causing PHC fractures were determined. METHODS: This paper presents the development and validation of a detailed 3D finite element model with high anatomical fidelity of the PHC and BMD changes in trabecular and cortical bones, modelled based on CT scans...
2018: Acta of Bioengineering and Biomechanics
https://www.readbyqxmd.com/read/29657849/talar-process-fractures-an-overview-and-update-of-the-literature
#13
Haroon Majeed, Donald J McBride
Fractures of the lateral and the posterior processes of the talus are uncommon and frequently missed because of a low level of suspicion and difficulty in interpretation on plain radiographs. Missed fractures can lead to persistent pain and reduced function.Lateral process fractures are usually a consequence of forced dorsiflexion and inversion of fixed pronated foot. These are also commonly known as snowboarder's fractures.The posterior process of the talus is composed of medial and lateral tubercles, separated by the groove for the flexor hallucis longus tendon...
March 2018: EFORT Open Reviews
https://www.readbyqxmd.com/read/29657444/radial-axial-interosseous-load-rail-test-for-essex-lopresti-type-injuries
#14
REVIEW
Zachary C Lum, Eric G Huish, Marc A Trzeciak
Background: When approaching radial head and neck fractures, the decision for ORIF, resection, or arthroplasty is often performed intraoperatively. Factors that contribute include ligamentous and bony stability, cartilage injury, mechanical alignment as well as patient factors. Recent data has suggested conventional methods may not be sufficiently sensitive in detecting Essex Lopresti injuries. Here we describe an intraoperative technique that could objectively assess proximal radio-ulnar stability with subsequent disruption of the ligamentous structures...
March 2018: Journal of Orthopaedics
https://www.readbyqxmd.com/read/29656073/protective-therapeutic-effects-of-peptide-nanofiber-and-hyaluronic-acid-hybrid-membrane-in-in-vivo-osteoarthritis-model
#15
Elif Arslan, Melis Sardan Ekiz, Cagla Eren Cimenci, Nuray Can, M Hanifi Gemci, Huseyin Ozkan, Mustafa O Guler, Ayse B Tekinay
Osteoarthritis (OA) is a condition where tissue function is lost through a combination of secondary inflammation and deterioration in articular cartilage. One of the most common causes of OA is age-related tissue impairment because of wear and tear due to mechanical erosion. Hyaluronic acid-based viscoelastic supplements have been widely used for the treatment of knee injuries. However, the current formulations of hyaluronic acid are unable to provide efficient healing and recovery. Here, a nanofiber-hyaluronic acid membrane system that was prepared by using a quarter of the concentration of commercially available hyaluronic acid supplement, Hyalgan® , was used for the treatment of an osteoarthritis model, and Synvisc® , which is another commercially available hyaluronic acid containing viscoelastic supplement, was used as a control...
April 12, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29644281/thyrohyoid-membrane-transection-caused-by-a-stab-injury
#16
Dongsub Noh, Kwang Hee Yeo, Hyun Min Cho, Chan Yong Park
Background: The thyrohyoid membrane is located between the hyoid bone and thyroid cartilage. Transection of the thyrohyoid membrane can be fatal. Case presentation: A 54-year-old man presented to the emergency room after attempting to commit suicide by cutting his neck. An endotracheal tube was inserted through the thyrohyoid membrane, which had been cut almost completely. After a tracheostomy, temporary wound closure was performed due to coagulopathy caused by hemorrhagic shock...
December 2017: Trauma Case Reports
https://www.readbyqxmd.com/read/29629574/acetabular-delamination-epidemiology-histological-features-and-treatment
#17
Eugenio Jannelli, Antonina Parafioriti, Alberto Acerbi, Alessandro Ivone, Alberto Fioruzzi, Andrea Fontana
Objective The International Cartilage Repair Society classification is the one mainly used to define chondral defects. However, this classification does not include delamination. The objective of the study is to describe the characteristics of this lesion to better explain its classification in the context of chondral lesions of the hip. Design We performed a retrospective analysis of 613 patients who underwent hip arthroscopy. In this group, the incidence, localization, histological characteristics, and association to femoroacetabular impingement as well as to other intraarticular lesions of acetabular delamination (AD) were analyzed...
April 1, 2018: Cartilage
https://www.readbyqxmd.com/read/29628132/biomechanics-of-osteochondral-impact-with-cushioning-and-graft-insertion-cartilage-damage-is-correlated-with-delivered-energy
#18
Alvin W Su, Yunchan Chen, Yao Dong, Dustin H Wailes, Van W Wong, Albert C Chen, Shengqiang Cai, William D Bugbee, Robert L Sah
Articular cartilage is susceptible to impact injury. Impact may occur during events ranging from trauma to surgical insertion of an OsteoChondral Graft (OCG) into an OsteoChondral Recipient site (OCR). To evaluate energy density as a mediator of cartilage damage, a specialized drop tower apparatus was used to impact adult bovine samples while measuring contact force, cartilage surface displacement, and OCG advancement. When a single impact was applied to an isolated (non-inserted) OCG, force and surface displacement each rose monotonically and then declined...
March 30, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29621661/gene-therapy-for-repair-and-regeneration-of-bone-and-cartilage
#19
REVIEW
Matthew W Grol, Brendan H Lee
Gene therapy refers to the use of viral and non-viral vectors to deliver nucleic acids to tissues of interest using direct (in vivo) or transduced cell-mediated (ex vivo) approaches. Over the past few decades, strategies have been adopted to express therapeutic transgenes at sites of injury to promote or facilitate repair of bone and cartilage. Targets of interest have typically included secreted proteins such as growth factors and anti-inflammatory mediators; however, work has also begun to focus intracellularly on signaling components, transcription factors and small, regulatory nucleic acids such as microRNAs (miRNAs)...
April 2, 2018: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/29621359/applying-chlorogenic-acid-in-an-alginate-scaffold-of-chondrocytes-can-improve-the-repair-of-damaged-articular-cartilage
#20
Xin Cheng, Ke Li, Shengsong Xu, Peizhi Li, Yu Yan, Guang Wang, Zachary Berman, Rui Guo, Jianxin Liang, Sira Traore, Xuesong Yang
Damaged cartilage has very low regenerative potential which has led to the search for novel tissue-engineering approaches to help treat cartilage defects. While various approaches have been reported, there is no perfect treatment currently. In this study we evaluated the effects of a plant extract, chlorogenic acid (CGA), as part of chondrocyte transplantation on a model of knee joint injury in chicks. First, primary cultured chondrocytes used to evaluate the effects of CGA on chondrogenesis. Then using an articular cartilage injury model of chick knee we assessed the functional recovery after transplantation of the complexes containing chondrocytes and CGA in an alginate scaffold...
2018: PloS One
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