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https://www.readbyqxmd.com/read/29453548/-big-data-from-clinical-routine
#1
REVIEW
U Mansmann
BACKGROUND: Over the past 100 years, evidence-based medicine has undergone several fundamental changes. Through the field of physiology, medical doctors were introduced to the natural sciences. Since the late 1940s, randomized and epidemiological studies have come to provide the evidence for medical practice, which led to the emergence of clinical epidemiology as a new field in the medical sciences. Within the past few years, big data has become the driving force behind the vision for having a comprehensive set of health-related data which tracks individual healthcare histories and consequently that of large populations...
February 16, 2018: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/29441511/-cardiology-telemedicine-solutions-opinion-of-the-committee-of-informatics-and-telemedicine-of-polish-society-of-cardiology-section-of-non-invasive-electrocardiology-and-telemedicine-of-polish-society-of-cardiology-and-clinical-sciences-committee-of-the
#2
Ryszard Piotrowicz, Paweł Krzesiński, Paweł Balsam, Maciej Kempa, Renata Główczyńska, Marcin Grabowski, Łukasz Kołtowski, Ewa Lewicka, Michał Peller, Ewa Piotrowicz, Jakub Podolec, Adam Stańczyk, Justyna Zajdel, Grzegorz Opolski
For several years, we have observed the dynamic development of technologies that allow patients to access medical care from the comfort of their homes, without direct contact with the doctor. Innovative solutions based on telemedicine improve care coordination and communication among clinicians, patients, and their families, as well as increases patients' security and gives them greater independence, thus eliminating health care inequalities. The rapidly growth of telemedicine and the adoption of new technologies in clinical practice is also observed in Poland...
February 14, 2018: Kardiologia Polska
https://www.readbyqxmd.com/read/29431517/informatics-and-machine-learning-to-define-the-phenotype
#3
Anna Okula Basile, Marylyn DeRiggi Ritchie
For the past decade, the focus of complex disease research has been the genotype. From technological advancements to the development of analysis methods, great progress has been made. However, advances in our definition of the phenotype have remained stagnant. Phenotype characterization has recently emerged as an exciting area of informatics and machine learning. The copious amounts of diverse biomedical data that have been collected may be leveraged with data-driven approaches to elucidate trait-related features and patterns...
February 12, 2018: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/29421009/how-well-does-early-career-investigators-cardiovascular-outcomes-research-training-align-with-funded-outcomes-research
#4
Matthew J Crowley, Sana M Al-Khatib, Tracy Y Wang, Prateeti Khazanie, Nancy R Kressin, Harlan M Krumholz, Catarina I Kiefe, Barbara L Wells, Sean M O'Brien, Eric D Peterson, Gillian D Sanders
BACKGROUND: Outcomes research training programs should prepare trainees to successfully compete for research funding. We examined how early-career investigators' prior and desired training aligns with recently funded cardiovascular (CV) outcomes research. METHODS: We (1) reviewed literature to identify 13 core competency areas in CV outcomes research; (2) surveyed early-career investigators to understand their prior and desired training in each competency area; (3) examined recently funded grants commonly pursued by early-career outcomes researchers to ascertain available funding in competency areas; and (4) analyzed alignment between investigator training and funded research in each competency area...
February 2018: American Heart Journal
https://www.readbyqxmd.com/read/29420787/military-health-system-transformation-implications-on-health-information-technology-modernization
#5
Saad Khan
With the recent passage of the National Defense Authorization Act for Fiscal Year 2017, Congress has triggered groundbreaking Military Health System organizational restructuring with the Defense Health Agency assuming responsibility for managing all hospitals and clinics owned by the Army, Navy, and Air Force. This is a major shift toward a modern value-based managed care system, which will require much greater military-civilian health care delivery integration to be in place by October 2018. Just before the National Defense Authorization Act for Fiscal Year 2017 passage, the Department of Defense had already begun a seismic shift and awarded a contract for the new Military Health System-wide electronic health record system...
February 6, 2018: Military Medicine
https://www.readbyqxmd.com/read/29417567/breaking-down-barriers-to-effective-patient-care
#6
EDITORIAL
Peter H O'Donnell, Kellie Schoolar Reynolds
The theme for the 2018 ASCPT Annual Meeting is "Breaking Down Barriers to Effective Patient Care." This theme refers to the essential contributions of clinical pharmacology to the development of today's discovery into tomorrow's medicine. The various subdisciplines within clinical pharmacology serve to move molecules through the various stages of drug development and also refine or expand use of the drug postapproval. The wide range of topics covered by the 2018 Annual Meeting scientific program demonstrates the breadth of clinical pharmacology's impact...
March 2018: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29408543/precision-medicine-in-cow-milk-allergy-proteomics-perspectives-from-allergens-to-patients
#7
Enza D' Auria, Chiara Mameli, Cristian Piras, Lucia Cococcioni, Andrea Urbani, Gian Vincenzo Zuccotti, Paola Roncada
Cow's milk allergy (CMA) is one of the most common food allergies, especially during childhood. CMA is an immunological mediated adverse reaction to one or more cow's milk proteins, which are normally harmless to a non-allergic individual, as the result of a failure of oral tolerance. To make a correct diagnosis of CMA and a proper treatment are critical in clinical practice. Application of proteomics along with new bio-informatics tools in the field of food allergy is one of the hot topics presented in recent years...
February 3, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29397021/-send-hold-clinical-decision-support-rules-improvement-to-reduce-unnecessary-testing-of-vitamins-a-e-k-b1-b2-b3-b6-and-c
#8
Enrique Rodriguez-Borja, Africa Corchon-Peyrallo, Esther Barba-Serrano, Celia Villalba Martínez, Arturo Carratala Calvo
BACKGROUND: We assessed the impact of several "send & hold" clinical decision support rules (CDSRs) within the electronical request system for vitamins A, E, K, B1, B2, B3, B6 and C for all outpatients at a large health department. METHODS: When ordered through electronical request, providers (except for all our primary care physicians who worked as a non-intervention control group) were always asked to answer several compulsory questions regarding main indication, symptomatology, suspected diagnosis, vitamin active treatments, etc...
February 3, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29396851/medications-that-relax-the-lower-oesophageal-sphincter-and-risk-of-oesophageal-cancer-an-analysis-of-two-independent-population-based-databases
#9
Andrew D Spence, John Busby, Peter Murchie, Andrew T Kunzmann, Úna C McMenamin, Helen G Coleman, Brian T Johnston, Michael A O'Rorke, Liam J Murray, Lisa Iversen, Amanda J Lee, Chris R Cardwell
Excessive lower oesophageal sphincter relaxation increases gastro-oesophageal acid reflux, an oesophageal adenocarcinoma risk factor. Medications that relax this sphincter (benzodiazepines, calcium channel blockers, nitrates, β2 agonists and xanthines) could promote cancer. These medications were investigated in two independent datasets. In the Scottish Primary Care Clinical Informatics Unit (PCCIU) database, a nested case-control study of oesophageal cancer was performed using GP prescription records. Conditional logistic regression was used to calculate odds ratios (OR) and 95% confidence intervals (CIs) for medication use and oesophageal cancer...
February 3, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29396322/a-landscape-of-metabolic-variation-across-tumor-types
#10
Ed Reznik, Augustin Luna, Bülent Arman Aksoy, Eric Minwei Liu, Konnor La, Irina Ostrovnaya, Chad J Creighton, A Ari Hakimi, Chris Sander
Tumor metabolism is reorganized to support proliferation in the face of growth-related stress. Unlike the widespread profiling of changes to metabolic enzyme levels in cancer, comparatively less attention has been paid to the substrates/products of enzyme-catalyzed reactions, small-molecule metabolites. We developed an informatic pipeline to concurrently analyze metabolomics data from over 900 tissue samples spanning seven cancer types, revealing extensive heterogeneity in metabolic changes relative to normal tissue across cancers of different tissues of origin...
January 26, 2018: Cell Systems
https://www.readbyqxmd.com/read/29396125/performing-an-informatics-consult-methods-and-challenges
#11
Alejandro Schuler, Alison Callahan, Kenneth Jung, Nigam H Shah
Our health care system is plagued by missed opportunities, waste, and harm. Data generated in the course of care are often underutilized, scientific insight goes untranslated, and evidence is overlooked. To address these problems, we envisioned a system where aggregate patient data can be used at the bedside to provide practice-based evidence. To create that system, we directly connect practicing physicians to clinical researchers and data scientists through an informatics consult. Our team processes and classifies questions posed by clinicians, identifies the appropriate patient data to use, runs the appropriate analyses, and returns an answer, ideally in a 48-hour time window...
January 22, 2018: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29393522/derivation-and-validation-of-a-clostridium-difficile-infection-recurrence-prediction-rule-in-a-national-cohort-of-veterans
#12
Kelly R Reveles, Eric M Mortensen, Jim M Koeller, Kenneth A Lawson, Mary Jo V Pugh, Sarah A Rumbellow, Jacqueline R Argamany, Christopher R Frei
STUDY OBJECTIVE: Prior studies have identified risk factors for recurrent Clostridium difficile infection (CDI), but few studies have integrated these factors into a clinical prediction rule that can aid clinical decision making. The objective of this study was to derive and validate a CDI recurrence prediction rule to identify patients at risk for first recurrence in a national cohort of veterans. DESIGN: Retrospective cohort study. DATA SOURCE: Veterans Affairs Informatics and Computing Infrastructure...
February 2, 2018: Pharmacotherapy
https://www.readbyqxmd.com/read/29393191/acute-kidney-injury-and-big-data
#13
Scott M Sutherland, Stuart L Goldstein, Sean M Bagshaw
The recognition of a standardized, consensus definition for acute kidney injury (AKI) has been an important milestone in critical care nephrology, which has facilitated innovation in prevention, quality of care, and outcomes research among the growing population of hospitalized patients susceptible to AKI. Concomitantly, there have been substantial advances in "big data" technologies in medicine, including electronic health records (EHR), data registries and repositories, and data management and analytic methodologies...
2018: Contributions to Nephrology
https://www.readbyqxmd.com/read/29389426/registry-assessment-of-peripheral-interventional-devices-rapid-registry-assessment-of-peripheral-interventional-devices-core-data-elements
#14
W Schuyler Jones, Mitchell W Krucoff, Pablo Morales, Rebecca W Wilgus, Anne H Heath, Mary F Williams, James E Tcheng, J Danica Marinac-Dabic, Misti L Malone, Terrie L Reed, Rie Fukaya, Robert A Lookstein, Nobuhiro Handa, Herbert D Aronow, Daniel J Bertges, Michael R Jaff, Thomas T Tsai, Joshua A Smale, Margo J Zaugg, Robert J Thatcher, Jack L Cronenwett
OBJECTIVE: The current state of evaluating patients with peripheral artery disease and more specifically of evaluating medical devices used for peripheral vascular intervention (PVI) remains challenging because of the heterogeneity of the disease process, the multiple physician specialties that perform PVI, the multitude of devices available to treat peripheral artery disease, and the lack of consensus about the best treatment approaches. Because PVI core data elements are not standardized across clinical care, clinical trials, and registries, aggregation of data across different data sources and physician specialties is currently not feasible...
February 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29367497/registry-assessment-of-peripheral-interventional-devices-rapid-%C3%A3-registry-assessment-of-peripheral-interventional-devices-core-data-elements
#15
W Schuyler Jones, Mitchell W Krucoff, Pablo Morales, Rebecca W Wilgus, Anne H Heath, Mary F Williams, James E Tcheng, J Danica Marinac-Dabic, Misti L Malone, Terrie L Reed, Rie Fukaya, Robert Lookstein, Nobuhiro Handa, Herbert D Aronow, Daniel J Bertges, Michael R Jaff, Thomas T Tsai, Joshua A Smale, Margo J Zaugg, Robert J Thatcher, Jack L Cronenwett, Durham Nc, Silver Spring Md, Tokyo Japan, New York Ny, Providence Ri, Burlington Vt, Newton Mass, Denver Colo, Tempe Ariz, Santa Clara Calif, Minneapolis Minn, Lebanon Nh
BACKGROUND: The current state of evaluating patients with peripheral artery disease and more specifically of evaluating medical devices used for peripheral vascular intervention (PVI) remains challenging because of the heterogeneity of the disease process, the multiple physician specialties that perform PVI, the multitude of devices available to treat peripheral artery disease, and the lack of consensus about the best treatment approaches. Because PVI core data elements are not standardized across clinical care, clinical trials, and registries, aggregation of data across different data sources and physician specialties is currently not feasible...
January 25, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29358341/temporal-effects-of-combined-birinapant-and-paclitaxel-on-pancreatic-cancer-cells-investigated-via-large-scale-ion-current-based-quantitative-proteomics-ionstar
#16
Xue Wang, Jin Niu, Jun Li, Xiaomeng Shen, Shichen Shen, Robert M Straubinger, Jun Qu
Despite decades of effort, pancreatic adenocarcinoma (PDAC) remains an intractable clinical challenge. An insufficient understanding of mechanisms underlying tumor cell responses to chemotherapy contributes significantly to the lack of effective treatment regimens. Here, paclitaxel, a first-line chemotherapeutic agent, was observed to interact synergistically with birinapant, a Second Mitochondrial-derived Activator of Caspases mimetic. Therefore, we investigated molecular-level drug interaction mechanisms using comprehensive, reproducible, and well-controlled ion-current-based MS1 quantification (IonStar)...
January 22, 2018: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/29350683/ccat1-stimulation-of-the-symmetric-division-of-nsclc-stem-cells-through-activation-of-the-wnt-signalling-cascade
#17
Chongwen Xu, Guodong Xiao, Boxiang Zhang, Meng Wang, Jichang Wang, Dapeng Liu, Jing Zhang, Hong Ren, Xin Sun
Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related mortalities worldwide, yet this condition remains a poorly understood malignancy, and the subgroup of cancer stem cells (CSCs) leading to therapeutic resistance and adverse prognosis have not been well studied. CSCs frequently undergo symmetric division, which facilitates expansion of the stem cell pool, contributing to long-term relapse and therapy failure. CCAT1 could act as a miRNA sponge to influence downstream genes; however, its roles in NSCLC stem cell are unclear...
January 19, 2018: Gene Therapy
https://www.readbyqxmd.com/read/29344894/systems-biology-approaches-in-cancer-pathology
#18
Aaron DeWard, Rebecca J Critchley-Thorne
The complex network of the tissue system, in both pre-neoplastic tissues and tumors, demonstrates the need for a systems biology approach to cancer pathology, in which quantification of key tissue system processes is combined with informatics tools to produce actionable scores to aid clinical decision-making. A systems biology approach to cancer pathology enables integration of key system features that are relevant to diagnoses, patient outcomes, and responses to therapies. Key tissue system features relevant to cancer pathology include molecular and morphologic abnormalities in epithelia, cellular changes in the stroma such as immune infiltrates, and relationships between components of the system, such as interactions and spatial relationships between epithelial and stromal components, and also between specific immune cell subsets...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29334353/genesis-of-a-uk-faculty-of-clinical-informatics-at-a-time-of-anticipation-for-some-and-ruby-golden-and-diamond-celebrations-for-others
#19
Simon De Lusignan, Jeremy Barlow, Philip J Scott
This Editorial marks the launch of the UK Faculty of Clinical Informatics (FCI) at the time when non-clinically qualified informaticians are anticipating the lauch of  the Federation of Informatics Professionals in Health and Care (Fed-IP).
January 12, 2018: Journal of Innovation in Health Informatics
https://www.readbyqxmd.com/read/29316298/improving-the-safety-assessment-of-chemicals-and-drug-candidates-by-the-integration-of-bio-informatics-and-chemoinformatics-data
#20
Thomas Steger-Hartmann, Francois Pognan
The application of read-across and in silico tools for regulatory decision-making has been limited for pharmaceutical compounds to the assessment of genotoxic impurity. In contrast, the broad availability of toxicity data for industrial chemicals has triggered regulatory frameworks for read-across (e.g. ECHA read-across assessment framework), software tools and public databases for an automated process of gap filling for safety assessment framework. This MiniReview provides an overview of the currently existing in silico and read-across approaches for chemicals together with recent developments for pharmaceutical compounds in these areas...
January 7, 2018: Basic & Clinical Pharmacology & Toxicology
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