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https://www.readbyqxmd.com/read/29668140/-standardization-of-a-multiplex-real-time-pcr-test-for-the-identification-of-angiostrongylus-cantonensis-a-costaricensis-and-a-vasorum
#1
Rubén E Varela-M, Jinney Stefany Arias, Luz Elena Velásquez
INTRODUCTION: Angiostrongyliasis is a disease caused by Angiostrongylus nematodes that is present worldwide. The infections with the highest impact on human and animal health are caused by A. cantonensis, A. costaricensis, and A. vasorum. Clinical forms of the disease in humans are eosinophilic meningitis and abdominal angiostrongyliasis, while the most common effect on dogs are cardiopulmonary damages. It is deemed as an emerging disease as the result of the global dissemination of the African snail Lissachatina fulica, an intermediary host of these parasites...
March 15, 2018: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/29656848/the-discipline-of-epidemiology-engaging-in-the-full-breadth-of-population-health-science
#2
EDITORIAL
Harold I Feldman
This address was delivered by Harold I. Feldman, MD, MSCE, at the Annual Meeting of the American College of Epidemiology in New Orleans, Louisiana, on September 26, 2017. Dr. Feldman is George S. Pepper Professor of Public Health and Preventive Medicine, Professor of Epidemiology and Medicine, and Chair, Department of Biostatistics, Epidemiology, and Informatics at the Perelman School of Medicine at the University of Pennsylvania. He is recognized nationally and internationally for his expertise in kidney disease epidemiology...
March 21, 2018: Annals of Epidemiology
https://www.readbyqxmd.com/read/29649348/development-of-the-american-college-of-rheumatology-electronic-clinical-quality-measures-for-gout
#3
John D Fitzgerald, Ted R Mikuls, Tuhina Neogi, Jasvinder A Singh, Mark Robbins, Puja P Khanna, Amy S Turner, Rachel Myslinski, Lisa G Suter
OBJECTIVE: Electronic clinical quality measures (eCQMs) are increasingly used by health registries and third parties to evaluate and improve the quality of health care. To complete these eCQMs, data are extracted from electronic health records (EHRs). The treatment of gout has been an area identified with gaps in quality of care. On behalf of the American College of Rheumatology (ACR), we sought to develop and test eCQMs to evaluate gout care. METHODS: Drawing from the 2012 ACR gout guidelines, a working group developed candidate gout process measures that were evaluated by an interdisciplinary panel of health care stakeholders, the ACR Quality Measures Subcommittee (QMS), and ultimately the ACR Board of Directors for formal validity testing...
April 12, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29629054/health-information-technology-in-ambulatory-care-in-a-developing-country
#4
Ghasem Deimazar, Mehdi Kahouei, Afsane Zamani, Zahra Ganji
Background: Physicians need to apply new technologies in ambulatory care. At present, with regard to the extended use of information technology in other departments in Iran it has yet to be considerably developed by physicians and clinical technicians in the health department. Objective: To determine the rate of use of health information technology in the clinics of specialist- and subspecialist physicians in Semnan city, Iran. Methods: This was a 2016 cross-sectional study conducted in physicians' offices of Semnan city in Iran...
February 2018: Electronic Physician
https://www.readbyqxmd.com/read/29626127/apto-253-stabilizes-g-quadruplex-dna-inhibits-myc-expression-and-induces-dna-damage-in-acute-myeloid-leukemia-cells
#5
Andrea Local, Hongying Zhang, Khalid D Benbatoul, Peter Folger, Xia Sheng, Cheng-Yu Tsai, Stephen B Howell, William G Rice
APTO-253 is a Phase 1 clinical stage small molecule that selectively induces CDKN1A (p21), promotes G0/G1 cell cycle arrest and triggers apoptosis in acute myeloid leukemia (AML) cells without producing myelosuppression in various animal species and humans. Differential gene expression analysis identified a pharmacodynamic effect on MYC expression, as well as induction of DNA repair and stress response pathways. APTO-253 was found to elicit a concentration-dependent and time-dependent reduction in MYC mRNA expression and protein levels...
April 6, 2018: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/29621832/identifying-associations-between-somatic-mutations-and-clinicopathologic-findings-in-lung-cancer-pathology-reports
#6
Nishant Kumar, Laura J Tafe, John H Higgins, Jason D Peterson, Francise Blumental de Abreu, Sophie J Deharvengt, Gregory J Tsongalis, Christopher I Amos, Saeed Hassanpour
OBJECTIVE: We aim to build an informatics methodology capable of identifying statistically significant associations between the clinical findings of non-small cell lung cancer (NSCLC) recorded in patient pathology reports and the various clinically actionable genetic mutations identified from next-generation sequencing (NGS) of patient tumor samples. METHODS: We built an information extraction and analysis pipeline to identify the associations between clinical findings in the pathology reports of patients and corresponding genetic mutations...
February 2018: Methods of Information in Medicine
https://www.readbyqxmd.com/read/29621387/diagnostic-accuracy-of-ophthalmoscopy-vs-telemedicine-in-examinations-for-retinopathy-of-prematurity
#7
Hilal Biten, Travis K Redd, Chace Moleta, J Peter Campbell, Susan Ostmo, Karyn Jonas, R V Paul Chan, Michael F Chiang
Importance: Examinations for retinopathy of prematurity (ROP) are typically performed using binocular indirect ophthalmoscopy. Telemedicine studies have traditionally assessed the accuracy of telemedicine compared with ophthalmoscopy as a criterion standard. However, it is not known whether ophthalmoscopy is truly more accurate than telemedicine. Objective: To directly compare the accuracy and sensitivity of ophthalmoscopy vs telemedicine in diagnosing ROP using a consensus reference standard...
April 5, 2018: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29602312/clinical-natural-language-processing-in-languages-other-than-english-opportunities-and-challenges
#8
REVIEW
Aurélie Névéol, Hercules Dalianis, Sumithra Velupillai, Guergana Savova, Pierre Zweigenbaum
BACKGROUND: Natural language processing applied to clinical text or aimed at a clinical outcome has been thriving in recent years. This paper offers the first broad overview of clinical Natural Language Processing (NLP) for languages other than English. Recent studies are summarized to offer insights and outline opportunities in this area. MAIN BODY: We envision three groups of intended readers: (1) NLP researchers leveraging experience gained in other languages, (2) NLP researchers faced with establishing clinical text processing in a language other than English, and (3) clinical informatics researchers and practitioners looking for resources in their languages in order to apply NLP techniques and tools to clinical practice and/or investigation...
March 30, 2018: Journal of Biomedical Semantics
https://www.readbyqxmd.com/read/29596094/database-quality-and-access-issues-relevant-to-research-using-anesthesia-information-management-system-data
#9
Richard H Epstein, Franklin Dexter
For this special article, we reviewed the computer code, used to extract the data, and the text of all 47 studies published between January 2006 and August 2017 using anesthesia information management system (AIMS) data from Thomas Jefferson University Hospital (TJUH). Data from this institution were used in the largest number (P = .0007) of papers describing the use of AIMS published in this time frame. The AIMS was replaced in April 2017, making this finite sample finite. The objective of the current article was to identify factors that made TJUH successful in publishing anesthesia informatics studies...
March 27, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29590633/disease-ontology-improving-and-unifying-disease-annotations-across-species
#10
Susan M Bello, Mary Shimoyama, Elvira Mitraka, Stanley J F Laulederkind, Cynthia L Smith, Janan T Eppig, Lynn M Schriml
Model organisms are vital to uncovering the mechanisms of human disease and developing new therapeutic tools. Researchers collecting and integrating relevant model organism and/or human data often apply disparate terminologies (vocabularies and ontologies), making comparisons and inferences difficult. A unified disease ontology is required that connects data annotated using diverse disease terminologies, and in which the terminology relationships are continuously maintained. The Mouse Genome Database (MGD, http://www...
March 12, 2018: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/29581716/a-meta-analysis-of-soluble-suppression-of-tumorigenicity-2-sst2-and-clinical-outcomes-in-pulmonary-hypertension
#11
King Sum Luk, Christina Ip, Meng-Qi Gong, Sunny Hei Wong, William Kk Wu, Mei Dong, Guang-Ping Li, Ka Pang Chan, Yi-Mei Du, Tong Liu, Martin Cs Wong, David Shu Cheong Hui, Gary Tse
No abstract text is available yet for this article.
December 2017: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/29572314/pharmacy-informatics-in-multihospital-health-systems-opportunities-and-challenges
#12
Jeffrey Chalmers, Mark Siska, Trinh Le, Scott Knoer
PURPOSE: Challenges and opportunities in managing pharmacy-related technology in a multihospital health system are reviewed. SUMMARY: With electronic medical record (EMR) implementations, pharmacy technology deployments, and increased numbers of hospitals merging into single health systems, opportunities and challenges for pharmacy informatics (PI) teams have grown. Pharmacy leaders must consider the implications of using technology in a multihospital health-system environment, as well as the impact of the health system's organizational structures on technology implementations and dedicated support teams...
April 1, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29572311/utilizing-big-data-to-provide-better-health-at-lower-cost
#13
Laney K Jones, Rebecca Pulk, Michael R Gionfriddo, Michael A Evans, Dean Parry
PURPOSE: The efficient use of big data in order to provide better health at a lower cost is described. SUMMARY: As data become more usable and accessible in healthcare, organizations need to be prepared to use this information to positively impact patient care. In order to be successful, organizations need teams with expertise in informatics and data management that can build new infrastructure and restructure existing infrastructure to support quality and process improvements in real time, such as creating discrete data fields that can be easily retrieved and used to analyze and monitor care delivery...
April 1, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29568713/translating-new-science-into-the-drug-review-process-the-us-fda-s-division-of-applied-regulatory-science
#14
Rodney Rouse, Naomi Kruhlak, James Weaver, Keith Burkhart, Vikram Patel, David G Strauss
In 2011, the US Food and drug Administration (FDA) developed a strategic plan for regulatory science that focuses on developing new tools, standards, and approaches to assess the safety, efficacy, quality, and performance of FDA-regulated products. In line with this, the Division of Applied Regulatory Science was created to move new science into the Center for Drug Evaluation and Research (CDER) review process and close the gap between scientific innovation and drug review. The Division, located in the Office of Clinical Pharmacology, is unique in that it performs mission-critical applied research and review across the translational research spectrum including in vitro and in vivo laboratory research, in silico computational modeling and informatics, and integrated clinical research covering clinical pharmacology, experimental medicine, and postmarket analyses...
March 2018: Therapeutic Innovation & Regulatory Science
https://www.readbyqxmd.com/read/29566172/biomedical-informatics-and-machine-learning-for-clinical-genomics
#15
James Diao, Isaac S Kohane, Arjun K Manrai
While tens of thousands of pathogenic variants are used in the myriad clinical applications of genomics, there remains limited quantitative risk information (i.e. penetrance) or consensus about the clinical utility of the majority of extant variants and tests. Relatedly, with the rising demand for genetic counseling, there is a need for computational approaches that scale the ability of counselors to interpret new and existing variants, whether by automating the determination of pathogenicity or filtering variants too common in the general population to be sufficiently penetrant...
March 16, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29562338/development-and-evaluation-of-a-novel-user-interface-for-reviewing-clinical-microbiology-results
#16
Adam Wright, Pamela M Neri, Skye Aaron, Thu-Trang T Hickman, Francine L Maloney, Daniel A Solomon, Dustin McEvoy, Angela Ai, Kevin Kron, Gianna Zuccotti
Background: Microbiology laboratory results are complex and cumbersome to review. We sought to develop a new review tool to improve the ease and accuracy of microbiology results review. Methods: We observed and informally interviewed clinicians to determine areas in which existing microbiology review tools were lacking. We developed a new tool that reorganizes microbiology results by time and organism. We conducted a scenario-based usability evaluation to compare the new tool to existing legacy tools, using a balanced block design...
March 17, 2018: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29557802/patient-and-system-characteristics-associated-with-performance-on-the-hedis-measures-of-alcohol-and-other-drug-treatment-initiation-and-engagement
#17
Bobbi Jo H Yarborough, Felicia W Chi, Carla A Green, Agatha Hinman, Jennifer Mertens, Arne Beck, Michael Horberg, Constance Weisner, Cynthia I Campbell
OBJECTIVES: Understand patient and system characteristics associated with performance on the Healthcare Effectiveness Data and Information Set (HEDIS) Alcohol and Other Drug (AOD) Initiation and Engagement of Treatment (IET) measures. METHODS: This mixed-methods study linked patient and health system data from four Kaiser Permanente regions to HEDIS performance measure data for 44,320 commercially or Medicare-insured adults with HEDIS-eligible AOD diagnoses in 2012...
March 19, 2018: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/29544780/using-modified-information-delivery-to-enhance-the-traditional-pharmacy-osce-program-at-tmu-a-pilot-study
#18
Che-Wei Lin, Elizabeth H Chang, Daniel L Clinciu, Yun-Ting Peng, Wen-Chen Huang, Chien-Chih Wu, Jen-Chieh Wu, Yu-Chuan Li
BACKGROUND AND OBJECTIVE: Objective Structured Clinical Examination (OSCE) has been used in many areas of healthcare training over the years. However, it constantly needs to be upgraded and enhanced due to technological and teaching changes. We aim at implementing an integrative OSCE method which employs informatics via the virtual patient within the pharmacy education curriculum at Taipei Medical University to enhance the pharmacy students' competence for using and disseminating information and to also improve critical thinking and clinical reasoning...
May 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29544642/characterization-of-the-ovarian-tumor-peptidome
#19
Tao Liu, Karin D Rodland, Richard D Smith
Aberrant degradation of proteins is associated with many pathological states, including cancers. Mass spectrometric analysis of the tumor peptidome has the potential to provide biological insights on proteolytic processing in cancer. However, attempts to use the tumors peptidome information in cancer research have been fairly limited to date, largely due to the lack of effective approaches for robust peptidomics identification and quantification, and the prevalence of confounding factors and biases associated with sample handling and processing...
2018: Vitamins and Hormones
https://www.readbyqxmd.com/read/29539190/mseqdr-mvtool-a-mitochondrial-dna-web-and-api-resource-for-comprehensive-variant-annotation-universal-nomenclature-collation-and-reference-genome-conversion
#20
Lishuang Shen, Marcella Attimonelli, Renkui Bai, Marie T Lott, Douglas C Wallace, Marni J Falk, Xiaowu Gai
Accurate mitochondrial DNA (mtDNA) variant annotation is essential for the clinical diagnosis of diverse human diseases. Substantial challenges to this process include the inconsistency in mtDNA nomenclatures, the existence of multiple reference genomes, and a lack of reference population frequency data. Clinicians need a simple bioinformatics tool that is user-friendly, and bioinformaticians need a powerful informatics resource for programmatic usage. Here, we report the development and functionality of the MSeqDR mtDNA Variant Tool set (mvTool), a one-stop mtDNA variant annotation and analysis web service...
March 14, 2018: Human Mutation
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