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Juvenile rheumatoid

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https://www.readbyqxmd.com/read/28530766/right-ring-finger-volar-mass-in-a-14-year-old-boy
#1
Mary P Fox, Jack E McKay, Randall D Craver, Nicholas D Pappas
A trigger digit is relatively uncommon in adolescents and often has a different etiology in that age group vs adults. In the pediatric population, trigger digits frequently arise from a variety of underlying anatomic situations, including thickening of the flexor digitorum superficialis or flexor digitorum profundus tendons, an abnormal relationship between the flexor digitorum superficialis and flexor digitorum profundus tendons, a proximal flexor digitorum superficialis decussation, or constriction of the pulleys...
May 20, 2017: Orthopedics
https://www.readbyqxmd.com/read/28530020/golimumab-a-review-in-inflammatory-arthritis
#2
James E Frampton
Golimumab (Simponi(®)), a fully human monoclonal antibody against tumour necrosis factor-alpha (TNFα), is given once monthly by subcutaneous injection. In the EU, golimumab is approved as monotherapy and/or in combination with methotrexate for the treatment of inflammatory arthritis, including rheumatoid arthritis (RA), psoriatic arthritis (PsA) and axial spondyloarthritis [comprising ankylosing spondylitis (AS) and non-radiographic axial spondyloarthritis (nr-axSpA)] in adults, and polyarticular juvenile idiopathic arthritis (pJIA) in children...
May 22, 2017: BioDrugs: Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
https://www.readbyqxmd.com/read/28528519/il-6-blockade-in-the-management-of-non-infectious-uveitis
#3
Giuseppe Lopalco, Claudia Fabiani, Jurgen Sota, Orso Maria Lucherini, Gian Marco Tosi, Bruno Frediani, Florenzo Iannone, Mauro Galeazzi, Rossella Franceschini, Donato Rigante, Luca Cantarini
Several pathogenetic studies have paved the way for a newer more rational therapeutic approach to non-infectious uveitis, and treatment of different forms of immune-driven uveitis has drastically evolved in recent years after the advent of biotechnological drugs. Tumor necrosis factor-α targeted therapies, the first-line recommended biologics in uveitis, have certainly led to remarkable results in patients with non-infectious uveitis. Nevertheless, the decision-making process turns out to be extremely difficult in anti-tumor necrosis factor or multidrug-resistant cases...
May 20, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28524764/lack-of-association-between-stat4-single-nucleotide-polymorphisms-and-iranian-juvenile-rheumatoid-arthritis-patients
#4
Saeed Aslani, Mahdi Mahmoudi, Arash Salmaninejad, Shiva Poursani, Vahid Ziaee, Nima Rezaei
Juvenile rheumatoid arthritis (JRA) is a common chronic systemic autoimmune disease in children. Single nucleotide polymorphisms (SNPs) of signal transducer and activator of transcription 4 (STAT4) gene are suspected to have association with the risk of autoimmune diseases. Previous investigations have indicated that the STAT4 rs7574865 T allele was significantly associated with rheumatoid arthritis. In this study, we aimed to evaluate the association of STAT4 SNPs with JRA in Iranian population. T allele of STAT4 rs7574865 SNP was less frequent in patients than in controls, and the difference was not significant (p = 0...
March 2, 2017: Fetal and Pediatric Pathology
https://www.readbyqxmd.com/read/28502061/validation-of-administrative-case-ascertainment-algorithms-for-chronic-childhood-arthritis-in-manitoba-canada
#5
Natalie Jane Shiff, Kiem Oen, Rasheda Rabbani, Lisa M Lix
We validated case ascertainment algorithms for juvenile idiopathic arthritis (JIA) in the provincial health administrative databases of Manitoba, Canada. A population-based pediatric rheumatology clinical database from April 1st 1980 to March 31st 2012 was used to test case definitions in individuals diagnosed at ≤15 years of age. The case definitions varied the number of diagnosis codes (1, 2, or 3), time frame (1, 2 or 3 years), time between diagnoses (ever, >1 day, or ≥8 weeks), and physician specialty...
May 13, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28494794/juvenile-idiopathic-arthritis-in-relation-to-perinatal-and-maternal-characteristics-a-case-control-study
#6
Samantha W Bell, Susan Shenoi, J Lee Nelson, Parveen Bhatti, Beth A Mueller
BACKGROUND: Existing data on associations between maternal and early childhood exposures and juvenile idiopathic arthritis (JIA) risk is scant and inconsistent with previous studies showing potential role for prematurity, number of siblings and infections. We explored JIA and International League of Associations for Rheumatology (ILAR) JIA categories in relation to selected infant (birthweight, size-for-gestational-age, gestational age), and maternal (parity, delivery type, prior fetal loss) characteristics that may be markers for exposures related to two pathways (hygiene hypothesis, microchimerism) potentially associated with autoimmune disorder occurrence...
May 11, 2017: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/28437514/a-retrospective-study-on-possible-predictive-factors-for-long-term-temporomandibular-joint-degeneration-and-impaired-mobility-in-juvenile-arthritis-patients
#7
Stanimira I Kalaykova, Adriaan T Klitsie, Corine M Visscher, Machiel Naeije, Frank Lobbezoo
AIMS: To determine possible predictive factors for long-term temporomandibular joint (TMJ) degeneration and dysfunction in juvenile idiopathic arthritis (JIA) patients. METHODS: A total of 94 patients (77% female) who had received a JIA diagnosis in an outpatient rheumatology clinic from 1993 to 1994 at a mean ± standard deviation age of 8.3 ± 4.53 years were included in the study. At inclusion, TMJ status regarding condylar degeneration was assessed orthopantomographically and given a Rohlin and Petersson score of 0 or ≥ 1...
April 2017: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/28428675/uveitis-associated-with-juvenile-idiopathic-arthritis-our-observations
#8
Almira Cosickic, Meliha Halilbasic, Amela Selimovic, Harun Avdagic
INTRODUCTION: Uveitis as extra-articular manifestation of juvenile idiopathic arthritis (JIA) is present in 20% of children with the persistent form, in 30% with the extended oligoarticular form, while it is present in psoriatic and polyarticular rheumatoid factor (RF) negative arthritis in 10% and 14%, respectively. AIM: The aim of the study was to evaluate the frequency of uveitis and its complications in children with JIA. MATERIAL AND METHODS: A retrospective study was conducted with an analysis of the medical records of children with JIA who were treated for the last 5 years...
February 2017: Medical Archives
https://www.readbyqxmd.com/read/28420491/telemedicine-for-patients-with-rheumatic-diseases-systematic-review-and-proposal-for-research-agenda
#9
REVIEW
Matteo Piga, Ignazio Cangemi, Alessandro Mathieu, Alberto Cauli
OBJECTIVE: To systematically review the scientific literature regarding tele-rheumatology and draw conclusions about feasibility, effectiveness, and patient satisfaction. METHODS: PubMed, Scopus, and Cochrane database searches were performed (April 2016) using relevant MeSH and keyword terms for telemedicine and rheumatic diseases. Articles were selected if reporting outcomes for feasibility, effectiveness, and patient satisfaction and methodologically appraised using the Cochrane Collaboration's tool for assessing risk of bias and a modified version of CONSORT 2010 Statement...
March 22, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28418334/juvenile-idiopathic-arthritis
#10
Kenan Barut, Amra Adrovic, Sezgin Şahin, Özgür Kasapçopur
Juvenile idiopathic arthritis is the most common chronic rheumatic disease of unknown aetiology in childhood and predominantly presents with peripheral arthritis. The disease is divided into several subgroups, according to demographic characteristics, clinical features, treatment modalities and disease prognosis. Systemic juvenile idiopathic arthritis, which is one of the most frequent disease subtypes, is characterized by recurrent fever and rash. Oligoarticular juvenile idiopathic arthritis, common among young female patients, is usually accompanied by anti-nuclear antibodie positivity and anterior uveitis...
April 5, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28412712/antitumor-necrosis-factor-%C3%AE-therapy-associated-with-inflammatory-bowel-disease-three-cases-and-a-systematic-literature-review
#11
Amir Bieber, Abdallah Fawaz, Irena Novofastovski, Reuven Mader
OBJECTIVE: Antitumor necrosis factor-α (anti-TNF-α) therapy is the most prescribed biologic agent therapy in rheumatology and gastroenterology. However, a number of serious side effects have been reported with these drugs. Only a handful of cases of new-onset inflammatory bowel disease (IBD), mostly in children diagnosed with juvenile idiopathic arthritis (JIA), have been reported during anti-TNF-α therapy. We present 3 cases of adult IBD following anti-TNF-α therapy and a literature review on this topic...
April 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28380667/antibodies-to-citrullinated-peptides-in-patients-with-juvenile-idiopathic-arthritis-and-rheumatoid-arthritis-shared-expression-of-the-inherently-autoreactive-9g4-idiotype
#12
Hannah Peckham, Geraldine Cambridge, Lauren Bourke, Debajit Sen, Anna Radziszewska, Maria Leandro, Yiannis Ioannou
Objective Antibodies to cyclic citrullinated peptides (CCP) in rheumatoid arthritis (RA) can express the inherently autoreactive gene, VH4-34, as detected using the rat monoclonal antibody, 9G4. Patients with the polyarticular sub-type of juvenile idiopathic arthritis (pJIA) share some but not all features of RA in adults. The aim of this study was to profile rheumatoid factor (RF), anti-CCP and 9G4-CCP serology of a large JIA cohort and compare to a cohort of adult RA patients. Methods Serum from 88 pJIA, 29 enthesitis-related arthritis (ERA), 38 extended oligoarthritis (EOA), 31 adolescent controls, 35 RA and 30 adult controls were tested for RF, IgG, IgA and IgM anti-CCP and 9G4+CCP by ELISA...
April 5, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28366220/standards-of-care-for-inflammatory-arthritis-a-literature-review
#13
REVIEW
Brooke A Wilson, Matthew Cooper, Claire E H Barber
OBJECTIVE: Quality standards are tools that may be used for advocacy, education, and for quality improvement purposes. The objective of this review is to describe the current landscape of quality standards for inflammatory arthritis (including rheumatoid arthritis, juvenile idiopathic arthritis, and spondyloarthritis), and to describe the methodology for standard development. METHODS: Three medical databases were reviewed, as well as major rheumatology and health care quality websites...
March 6, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28356614/a-study-on-the-physical-fitness-of-children-with-juvenile-rheumatoid-arthritis
#14
Hyo-Jeong Kwon, You Lim Kim, Hyun Soo Lee, Suk Min Lee
[Purpose] This study was conducted to assess the physical fitness of children with juvenile rheumatoid arthritis (JRA). [Subjects and Methods] In total, 26 children with juvenile rheumatoid arthritis (JRA) and 25 healthy controls participated in this study. Using the physical fitness measurement instruments, the Inbody 720 and Quark b2, the elements of physical fitness that were assessed included muscular strength, muscular endurance, flexibility, lung capacity, and body composition. [Results] The results revealed significant differences in muscular strength, muscular endurance, lung capacity, body composition, functional ability, and health-related quality of life between the children with juvenile rheumatoid arthritis (JRA) and the control group...
March 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28343613/effects-of-the-use-of-growth-hormone-in-children-and-adolescents-with-juvenile-idiopathic-arthritis-a-systematic-review
#15
Renan Bazuco Frittoli, Barbara Sugui Longui, Amanda Meireles Silva, Antônio de Azevedo Barros Filho, Maria Ângela Reis de Góes Monteiro, Simone Appenzeller
INTRODUCTION: Children with juvenile idiopathic arthritis (JIA) often have impaired growth and short stature. There is evidence that the therapeutic use of growth hormone (GH) is useful and safe in these patients. OBJECTIVE: To analyze the effects of GH use in patients with JIA. METHOD: A systematic review of the literature over the last 18 years in Medline and Embase databases. The criteria were analyzed independently by the researchers. We used the following keywords: "growth hormone", "arthritis, juvenile", "arthritis, rheumatoid", "child" and "adolescent"...
March 2017: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/28333965/worm-infestations-and-development-of-autoimmunity-in-children-the-abis-study
#16
Johnny Ludvigsson, Michael P Jones, Åshild Faresjö
Worm infestations influence the immune system and may therefore decrease the risk for autoimmune diseases. The aim of the study was to determine whether children who have developed autoimmune disease were less likely to have had worm infestations in childhood. The ABIS-study is a prospective population-based cohort study of children born in southeast Sweden 1997/99. 17.055 children participated. As of June 2014 116 individuals had developed Type 1 diabetes, 181 celiac disease, and 53 Juvenile Rheumatoid Arthritis...
2017: PloS One
https://www.readbyqxmd.com/read/28328098/plasma-exchange-successfully-treated-macrophage-activation-syndrome-in-rheumatoid-factor-positive-polyarticular-juvenile-idiopathic-arthritis-with-combined-pneumonia
#17
Lianjie Shi, Fanlei Hu, Chuanhui Xu, Huaqun Zhu, Di Qie, Chuanjie Yuan, Yuhong Tao, Hanmin Liu
Macrophage activation syndrome (MAS) is one of the serious complications associated with rheumatic diseases, especially systemic juvenile idiopathic arthritis (sJIA). Here we describe a 9-year-old girl with rheumatoid factor (RF)-positive polyarticular JIA, not sJIA, combined with pneumonia who was successfully treated by plasma exchange. She was diagnosed with RF-positive polyarticular JIA based on positive RF and multiple joint swelling and tenderness 3 years ago. She was admitted in our hospital with myalgia for 2 days and a high fever for half a day...
March 22, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28326423/removing-a-well-fixed-femoral-sleeve-during-revision-total-knee-arthroplasty
#18
J Ryan Martin, Tyler S Watters, Daniel L Levy, Jason M Jennings, Douglas A Dennis
The following surgical technique describes a case of a 51-year-old man with severe juvenile rheumatoid arthritis that required a 2-stage revision of an infected revision total knee implant. The patient had previously been implanted with a revision rotating platform, constrained condylar device which gained excellent fixation through the use of diaphyseal-engaging stems, and a well-ingrown, fully porous-coated femoral metaphyseal sleeve. To avoid intraoperative complications while removing the femoral sleeve, a novel technique for femoral sleeve extraction was used...
December 2016: Arthroplasty Today
https://www.readbyqxmd.com/read/28293448/serum-calreticulin-as-a-novel-biomarker-of-juvenile-idiopathic-arthritis-disease-activity
#19
Nashwa Ismail Hashaad, Rasha Mohamed Fawzy, Abeer Ahmed Abo Elazem, Mohamed Ibrahim Youssef
OBJECTIVE: This study aimed to investigate the relations between calreticulin (CRT) serum level and both disease activity and severity parameters in juvenile idiopathic arthritis (JIA). MATERIAL AND METHODS: In this study, 60 children with JIA and 50 age-and-sex-matched healthy subjects were enrolled. The assessment of the disease activity was done using juvenile arthritis disease activity score 27 (JADAS-27). The assessment of disease severity was done via gray-scale ultrasonography (US) and power Doppler US (PDUS)...
March 2017: European Journal of Rheumatology
https://www.readbyqxmd.com/read/28290137/sarilumab-first-global-approval
#20
REVIEW
Lesley J Scott
Sarilumab (Kevzara™) is a fully human IgG1 monoclonal antibody that binds specifically to both soluble and membrane-bound interleukin (IL)-6 receptors (sIL-6Rα and mIL-6Rα) and thereby inhibits IL-6-mediated signalling through these receptors. Subcutaneous sarilumab is approved in Canada for the treatment of adult patients with moderately to severely active rheumatoid arthritis who have had an inadequate response to one or more biological or non-biological disease-modifying anti-rheumatic drugs. It is under regulatory review for use in rheumatoid arthritis in other countries, including in the EU, USA and Japan...
April 2017: Drugs
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