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Hepatitis delta

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https://www.readbyqxmd.com/read/28805896/the-composition-of-dietary-fat-alters-the-transcriptional-profile-of-pathways-associated-with-lipid-metabolism-in-the-liver-and-adipose-tissue-in-the-pig
#1
T A Kellner, N K Gabler, J F Patience
The objective was to investigate the of effect chemical composition of dietary fat on transcription of genes involved in lipid metabolism in adipose tissue and the liver via transcriptional profiling in growing pigs. A total of 48 Genetiporc 6.0 × Genetiporc F25 (PIC, Inc., Hendersonville, TN) barrows (initial BW of 44.1 ± 1.2 kg) were randomly allotted to 1 of 6 dietary treatments. Each experimental diet included 95% of a corn-soybean meal basal diet and 5% cornstarch (control; CNTR), animal-vegetable blend (AV), coconut oil (COCO), corn oil (COIL), fish oil (FO), or tallow (TAL)...
August 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28795384/contribution-of-hepatobiliary-scintigraphy-in-assessing-alpps-most-suited-timing
#2
Stéphanie Truant, Clio Baillet, Anne Claire Deshorgue, Mehdi El Amrani, Damien Huglo, François-René Pruvot
To reduce post-hepatectomy liver failure (PHLF), associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) has been recently developed for patients with a limited future remnant liver (FRL). Nevertheless, high morbi-mortality rates have been reported . The current study aimed to analyze the kinetics of FRL function in patients who were offered ALPPS. Serial SPECT (99 m)Tc-mebrofenin hepatobiliary scintigraphy (HBS) was performed in all patients before and after surgery as well as at inter-stage to quantitatively assess hepatic function [total liver (TL) and FRL]...
August 9, 2017: Updates in Surgery
https://www.readbyqxmd.com/read/28774414/hepatitis-delta-infection-current-and-new-treatment-options
#3
REVIEW
Menashe Elazar, Christopher Koh, Jeffrey S Glenn
In humans, hepatitis D virus (HDV) infection only occurs in the presence of a concomitant hepatitis B virus (HBV) infection, and induces the most severe form of human viral hepatitis. Even though HDV is spread worldwide and is endemic in some regions, screening and treatment has been often neglected in part due to the lack of an effective therapy. Moreover, HDV prevalence rates are increasing in many countries driven by immigration from areas of high endemicity. Currently, no FDA-approved anti-HDV therapy is available, although interferon (IFN) alpha therapy has demonstrated benefit in a minority of patients...
June 2017: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/28760138/age-standardized-mortality-rates-related-to-viral-hepatitis-in-brazil
#4
Hugo Perazzo, Antonio G Pacheco, Paula M Luz, Rodolfo Castro, Chris Hyde, Juliana Fittipaldi, Caroline Rigolon, Sandra W Cardoso, Beatriz Grinsztejn, Valdiléa G Veloso
BACKGROUND: Liver-related mortality has been increasing worldwide. We aimed to estimate the age-standardized mortality rates from viral hepatitis in Brazil. METHODS: The Brazilian National Death Registry was analyzed from 2008 to 2014. Viral hepatitis deaths were defined by the following ICD-10 codes in the death certificate: hepatitis A [B15.0; B15.9]; hepatitis B [B16.2; B16.9; B18.1]; hepatitis C [B17.1; B18.2]; hepatitis Delta [B16.0; B16.1; B18.0; B17.0] and other viral hepatitis [B17...
July 31, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28751953/pcsk9-and-carbohydrate-metabolism-a-double-edged-sword
#5
EDITORIAL
Theodosios D Filippatos, Sebastian Filippas-Ntekouan, Eleni Pappa, Thalia Panagiotopoulou, Vasilios Tsimihodimos, Moses S Elisaf
Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays a paramount role in the degradation of low-density lipoprotein (LDL) receptors (LDLR) on the hepatic cells surface and subsequently affects LDL particles catabolism and LDL cholesterol (LDL-c) levels. The anti-PCSK9 monoclonal antibodies lead to substantial decrease of LDL-c concentration. PCSK9 (which is also expressed in pancreatic delta-cells) can decrease LDLR and subsequently decrease cholesterol accumulation in pancreatic beta-cells, which impairs glucose metabolism and reduces insulin secretion...
July 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28750657/rapid-expression-and-purification-of-the-hepatitis-delta-virus-antigen-using-the-methylotropic-yeast-pichia-pastoris
#6
Stephanie P Cartwright, Roslyn M Bill, Bui Tien Sy, Hieu Tran-Van, Hung Minh Nguyen
OBJECTIVE: Patients with dual hepatitis B (HBV) and hepatitis D (HDV) virus infection are at an increased risk of progression to liver cirrhosis and hepatocellular carcinoma than patients with a single viral infection. Treatment of viral hepatitis due to dual HBV/HDV infection represents a challenge. Currently there is no vaccine against HDV. Recombinant production of HDV antigen (HDAg) is the first step towards a potential vaccine candidate and the development of assays for HDV detection...
July 27, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28749453/mindfulness-based-stress-reduction-therapy-improves-patient-and-caregiver-reported-outcomes-in-cirrhosis
#7
Jasmohan S Bajaj, Michael Ellwood, Timothy Ainger, Thomas Burroughs, Andrew Fagan, Edith A Gavis, Douglas M Heuman, Michael Fuchs, Binu John, James B Wade
OBJECTIVES: Patient-reported outcomes such as health-related quality of life (HRQOL) are impaired in cirrhosis due to under-treated mood and sleep disorders, which can adversely impact their caregivers. Mindfulness-based stress reduction (MBSR) can improve patient-reported outcomes (PRO) in non-cirrhotic patients but their impact in cirrhosis is unclear. To evaluate the effect of MBSR and supportive group therapy on mood, sleep and HRQOL in cirrhotic patients and their caregivers. METHODS: Cirrhotic outpatients with mild depression (Beck Depression Inventory (BDI)>14) on screening with an adult caregiver were enrolled...
July 27, 2017: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/28742055/kinetic-validation-of-the-limax-test-during-10-000-intravenous-13c-methacetin-breath-tests
#8
Tom Moses Rubin, Karsten Heyne, Axel Luchterhand, Jan Bednarsch, Florian W Vondran, Georgios Polychronidis, Maciej Malinowski, Alen Nikolic, Hans-Michael Tautenhahn, Maximilian Jara, Tilo Wuensch, Martin Stockmann, Johan Friso Lock
The LiMAx test, a novel 13C-methacetin-breath-test, has proven clinical validity in determining the hepatic metabolic capacity. In contrast to prior 13C-methacetin-breath-test protocols, the LiMAx-test is performed by intravenous body-weight adjusted substrate administration. Furthermore, the DOB kinetics (Delta over Baseline of the time dependent exhaled 13CO2/12CO2-ratio) are measured online at bedside with a high time resolution in order to determine the DOB maximum. The aim of this study was to analyze the recorded DOB kinetics in a large population for further refinement of the test protocol...
July 25, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28740596/improved-hepascore-in-hepatitis-c-predicts-reversal-in-risk-of-adverse-outcome
#9
Angus W Jeffrey, Yi Huang, W Bastiaan de Boer, Leon A Adams, Gerry MacQuillan, David Speers, John Joseph, Gary P Jeffrey
AIM: To establish if serial Hepascore tests (referred to as delta Hepascore) in those with chronic hepatitis C (CHC) correlate with the increase and/or decrease in risk of liver related complications. METHODS: Three hundred and forty-six CHC patients who had two Hepascore tests performed were studied. During 1944 patient years follow-up 28 (8.1%) reached an endpoint. The Hepascore is a serum test that provides clinically useful data regarding the stage of liver fibrosis and subsequent clinical outcomes in chronic liver disease...
July 8, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28700067/acquired-hepatocerebral-degeneration-in-a-patient-with-hepatitis-b-and-hepatitis-delta-virus-coinfection
#10
Viviane de Carvalho, Dessana Francis Chehuan, Marcia Melo Damian
Acquired hepatocerebral degeneration is a neurological syndrome with typical clinical (extrapyramidal and neuropsychiatric) symptoms and brain magnetic resonance imaging findings (high T1 signal in the globus pallidus). It occurs mainly in patients with advanced liver disease, such as in patients co-infected with hepatitis B virus (HBV) and hepatitis delta virus (HDV). However, there are no reports relating HBV/HDV coinfection and acquired hepatocerebral degeneration. This report presents the case of a 49-year-old woman with characteristics of acquired hepatocerebral degeneration and liver cirrhosis due to HBV/HDV coinfection, and presents the main theories of the physiopathology of this condition...
May 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/28677645/hepatitis-delta-virus-replication-strategy-and-upcoming-therapeutic-options-for-a-neglected-human-pathogen
#11
REVIEW
Florian A Lempp, Stephan Urban
The human Hepatitis Delta Virus (HDV) is unique among all viral pathogens. Encoding only one protein (Hepatitis Delta Antigen; HDAg) within its viroid-like self-complementary RNA, HDV constitutes the smallest known virus in the animal kingdom. To disseminate in its host, HDV depends on a helper virus, the human Hepatitis B virus (HBV), which provides the envelope proteins required for HDV assembly. HDV affects an estimated 15-20 million out of the 240 million chronic HBV-carriers and disperses unequally in disparate geographical regions of the world...
July 4, 2017: Viruses
https://www.readbyqxmd.com/read/28676994/cimetidine-lactulose-therapy-ameliorates-erythropoietic-protoporphyria-related-liver-injury
#12
Naoyuki Fujimori, Michiharu Komatsu, Naoki Tanaka, Mai Iwaya, Hajime Nakano, Ayumi Sugiura, Tomoo Yamazaki, Soichiro Shibata, Yugo Iwaya, Takashi Muraki, Yuki Ichikawa, Takefumi Kimura, Satoru Joshita, Takeji Umemura, Akihiro Matsumoto, Eiji Tanaka
A 21-year-old Japanese man was admitted to our hospital because of severe abdominal pain and jaundice. He had been suffering from abdominal pain attacks and liver dysfunction since 18 years of age. Liver histology showed amorphous brown deposits in the sinusoidal space and significant periportal fibrosis without apparent hepatitis. Increased protoporphyrin in serum and feces and ferrochelatase gene mutation confirmed the final diagnosis of erythropoietic protoporphyria (EPP). Since ursodeoxycholic acid (UDCA) intake and glucose infusion are insufficient to ameliorate jaundice and abdominal attacks, cimetidine and lactulose were added in order to suppress hepatic delta-aminolevulinic acid synthase and limit re-absorption of protoporphyrin, respectively...
July 4, 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/28676076/prevalence-of-hepatitis-b-and-delta-according-to-hiv-type-a-multi-country-cross-sectional-survey-in-west-africa
#13
Patrick A Coffie, Boris K Tchounga, Guillaume Bado, Mathieu Kabran, Daouda K Minta, Gilles Wandeler, Geoffrey S Gottlieb, François Dabis, Serge P Eholie, Didier K Ekouevi
BACKGROUND: In West Africa where HIV-1 and HIV-2 co-circulate, the co-infection with hepatitis B virus (HBV) and hepatitis Delta virus (HDV) is not well described. This study aimed at estimating the prevalence of HBV and HBV/HDV co-infection according to HIV types and risk factors for HBV infection among West African HIV-infected patients. METHOD: A cross-sectional survey was conducted within the IeDEA West Africa cohort from March to December 2012 in Côte d'Ivoire (three sites), Burkina Faso and Mali (one site each)...
July 4, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28675280/-is-there-hope-for-hepatitis-delta
#14
Stefano Guglielmi, Jean-Louis Frossard, Francesco Negro
Hepatitis D or delta is a chronic liver disease globally reaching 15‑20M people. Its agent, hepatitis D virus (HDV) requires the presence of hepatitis B virus (HBV) to complete its life cycle. It represents one of the most severe forms of viral hepatitis. Current therapy with pegylated interferon alpha leads to viral eradication only in 25 % of cases. New treatments targeting the virus life cycle are sought. For example Myrcludex-B, which inhibits the entry into hepatocytes, lonafarnib which prevents the assemblage of the viral particle and the molecule REP 2139 which, among other unclear mechanisms, impedes the exit of the virus...
August 31, 2016: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28654602/a-morphometric-study-of-the-newborn-ear-and-an-analysis-of-factors-related-to-congenital-auricular-deformities
#15
Hui Zhao, Limin Ma, Xiangdong Qi, Jianzeng Qin, Baoming Yin, Mei Zhong, Yanjun He, Chenghong Wang
BACKGROUND: The incidence of neonatal ear deformities varies widely in the literature, and the incidence of those that correct spontaneously is largely unknown. To address these questions, the authors analyzed the auricles of 1500 newborns from the Pearl River Delta within the first 7 days of life and again at 30 days of age. METHODS: Using a combination of direct measurement and digital image measurement, the authors measured physiognomic ear length, physiognomic ear breadth, morphologic ear length, vertical distance between head and ear, and auriculocephalic angle of the newborns...
July 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28631044/-personalized-treatment-of-viral-hepatitis-of-the-present-and-the-future-hepatitis%C3%A2-b-c-delta-and-e
#16
REVIEW
R Bartenschlager, M Cornberg, T Pietschmann
Precision medicine is also possible for infectious diseases as shown for the treatment of chronic viral hepatitis, especially if different options are available. In hepatitis B virus (HBV) infection, treatment indication as well as the choice of treatment and the decisions to stop treatment are based on viral markers and alanine aminotransferase (ALT) level. Future therapies for HBV infection aiming for functional cure or even virus elimination may be even more personalized and have to take into account the immune status of a given patient...
June 19, 2017: Der Internist
https://www.readbyqxmd.com/read/28621670/analyses-of-a-whole-genome-inter-clade-recombination-map-of-hepatitis-delta-virus-suggest-a-host-polymerase-driven-and-viral-rna-structure-promoted-template-switching-mechanism-for-viral-rna-recombination
#17
Mei Chao, Tzu-Chi Wang, Chia-Chi Lin, Robert Yung-Liang Wang, Wen-Bin Lin, Shang-En Lee, Ying-Yu Cheng, Chau-Ting Yeh, Shan-Bei Iang
The genome of hepatitis delta virus (HDV) is a 1.7-kb single-stranded circular RNA that folds into an unbranched rod-like structure and has ribozyme activity. HDV redirects host RNA polymerase(s) (RNAP) to perform viral RNA-directed RNA transcription. RNA recombination is known to contribute to the genetic heterogeneity of HDV, but its molecular mechanism is poorly understood. Here, we established a whole-genome HDV-1/HDV-4 recombination map using two cloned sequences coexisting in cultured cells. Our functional analyses of the resulting chimeric delta antigens (the only viral-encoded protein) and recombinant genomes provide insights into how recombination promotes the genotypic and phenotypic diversity of HDV...
June 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28620012/metabolic-disturbances-of-non-alcoholic-fatty-liver-resemble-the-alterations-typical-for-type-2-diabetes
#18
Bram Brouwers, Vera B Schrauwen-Hinderling, Tomas Jelenik, Anne Gemmink, Bas Havekes, Yvonne Bruls, Dennis Dahlmans, Michael Roden, Matthijs K C Hesselink, Patrick Schrauwen
Non-alcoholic fatty liver (NAFL) is an independent risk factor for the development of type 2 diabetes (T2DM). We examined metabolic perturbations in people with NAFL, patients with T2DM and people with normal intrahepatic lipid (IHL) (CON). A 2-step (10mU/m(2)/min, 40mU/m(2)/min) hyperinsulinemic-euglycemic clamp was performed in 11 NAFL, 13 T2DM and 11 CON, all matched for BMI and aerobic fitness. IHL was measured using proton magnetic resonance spectroscopy. Because of high IHL variability in T2DM patients, this group was separated into a high IHL (IHL≥5...
June 15, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28611272/a-case-report-of-hepatocellular-carcinoma-5-years-after-hbsag-loss-in-chronic-hepatitis-delta-how-long-surveillance-is-required
#19
Laura Escolà-Vergé, Mar Riveiro-Barciela, Maria Buti
BACKGROUND: Hepatitis delta virus infection occurs as acute co-infection or as superinfection in patients with preexisting chronic hepatitis B. Chronic hepatitis delta leads to more severe disease than chronic hepatitis B, with more rapid progression of fibrosis and increased risk of hepatocelullar carcinoma. CASE REPORT: We report a case of hepatocelullar carcinoma 5 years after spontaneous clearance of Hepatitis B surface antigen in a patient with previous chronic hepatitis delta...
August 1, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/28573087/structural-and-nucleic-acid-binding-properties-of-hepatitis-delta-virus-small-antigen
#20
Carolina Alves, Hong Cheng, João Paulo Tavanez, Ana Casaca, Severin Gudima, Heinrich Roder, Celso Cunha
AIM: To further characterize the structure and nucleic acid binding properties of the 195 amino acid small delta antigen, S-HDAg, a study was made of a truncated form of S-HDAg, comprising amino acids 61-195 (∆60HDAg), thus lacking the domain considered necessary for dimerization and higher order multimerization. METHODS: Circular dichroism, and nuclear magnetic resonance experiments were used to assess the structure of ∆60HDAg. Nucleic acid binding properties were investigated by gel retardation assays...
May 12, 2017: World Journal of Virology
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