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Hepatitis delta

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https://www.readbyqxmd.com/read/29340126/hepatosplenic-gamma-delta-t-cell-lymphoma-hsgdtcl-two-rare-case-reports-from-western-india
#1
Irappa Madabhavi, Gaurang Modi, Harsha Panchal, Apurva Patel, Swaroop Revannasiddaiah, Asha Anand, Sonia Parikh, Kshitij Joshi, Malay Sarkar
Peripheral T cell lymphomas are a heterogeneous group of post-thymic, mature lymphoid malignancies, accounting for approximately 10-15% of all non-Hodgkin's lymphomas. Hepatosplenic T-cell lymphoma (HSGDTCL) is a rare entity, which is characterized by primary extra nodal disease with typical sinusoidal or sinusal infiltration of the liver and the spleen, respectively by expression of the T-cell receptor γδ chain, and by a number of other frequent clinicopathologic features, including aggressive course of disease...
October 1, 2017: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/29319168/hepatic-mir-125b-inhibits-insulin-signaling-pathway-by-targeting-pik3cd
#2
Xiliang Du, Xiaobing Li, Liang Chen, Min Zhan, Lin Lei, Wenwen Gao, Zhen Shi, Yuhao Dong, Zhe Wang, Xinwei Li, Guowen Liu
Insulin resistance is often characterized as the most critical factor contributing to the development of (T2D) type 2 diabetes. MicroRNAs (miRNAs) are endogenous non-coding short single-stranded RNAs that function as negative regulators in many physiological and pathological processes. The objective of this study was to evaluate the roles of miR-125b in the regulation of insulin sensitivity in hepatocytes. We found that hepatic miR-125b levels were significantly increased in the patients with type 2 diabetes, high fat diet (HFD) mice, ob/ob and db/db mice...
January 10, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29307146/prevalent-use-of-combined-prophylaxis-of-hepatitis-b-after-liver-transplantation-in-italy-results-of-a-national-survey-in-a-large-cohort
#3
Alfredo Marzano, Pietro Andreone, Patrizia Boccagni, Patrizia Burra, Francesco Caneschi, Pasquale F Conoscitore, Carmine Coppola, Luciano DE Carlis, Stefano Fagiuoli, Paolo Forte, Giovanni B Gaeta, Rosa M Iemmolo, Anna Lotti Suffredini, Michele Mazzola, Manuela Merli, Gianpaolo Parrilli, Guido Piai, Maria R Piras, Mauro Salizzoni, Mariarosa Tamè, Giuseppe Tisone, Pierluigi Toniutto, Giovanni Vennarecci, Riccardo Volpes, Fausto Zamboni, Lucio Caccamo
BACKGROUND: Prophylaxis of hepatitis B after liver transplantation with antiviral(s) and immunoglobulins efficiently protect the majority of recipients; however recent experiences suggest a decline of HBsAg-positive candidates and the use of hepatitis B Immunoglobulin-free schedules. METHODS: This national survey evaluated the epidemiology and clinical results of hepatitis B prophylaxis among 10,365 liver transplants performed in 25 years in 13 Italian centers. RESULTS: With a percentage of 22, 2260 procedures were performed in HBsAg-positive recipients and 714 out of 1080 anti-HBc-positive grafts were used in HBsAg-negative recipients; a total of 2974 patients (29%) were considered at risk of hepatitis B after liver transplantation...
March 2018: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/29303104/diagnosis-management-and-treatment-of-hepatitis-delta-virus-infection-turkey-2017-clinical-practice-guidelines
#4
Cihan Yurdaydın, Fehmi Tabak, Sabahattin Kaymakoğlu, Mesut Akarsu, Esra G Akıncı, Hikmet Akkız, Canan Alkım, Ayhan H Çekin, Nefise Ö Çuvalcı, Kadir Demir, Bülent Değertekin, İlyas Dökmetaş, Galip Ersöz, Kenan Hizel, Fatma Ö Kandemir, Yusuf Önlen, Abdullah Sonsuz, Ebubekir Şenateş, Selma Tosun, Nurdan Tözün, Ramazan Idilman, Viral Hepatitis Guidelines Study Group
No abstract text is available yet for this article.
December 2017: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/29291180/delta-model-for-end-stage-liver-disease-and-delta-clinical-prognostic-indicator-as-predictors-of-mortality-in-patients-with-viral-acute-liver-failure
#5
Ashok Kumar Pannu, Ashish Bhalla, Chelapati Rao, Charanpreet Singh
Objective: The objective of the study is to compare the model for end-stage liver disease (MELD) with clinical prognostic indicators (CPI) specifically the change in these parameters after 48 h of admission in predicting the mortality in patients with acute liver failure (ALF) due to acute viral hepatitis. Materials and Methods: An open label, investigator-initiated prospective study was conducted that included 41 patients with acute viral hepatitis with ALF. The cases were followed prospectively till death or discharge...
October 2017: International Journal of Critical Illness and Injury Science
https://www.readbyqxmd.com/read/29259325/clinical-characteristics-and-molecular-epidemiology-of-hepatitis-e-in-shenzhen-china-a-shift-toward-foodborne-transmission-of-hepatitis-e-virus-infection
#6
Siddharth Sridhar, Simon Kf Lo, Fanfan Xing, Jin Yang, Haiyan Ye, Jasper Fw Chan, Jade Ll Teng, Chuan Huang, Cyril Cy Yip, Susanna Kp Lau, Patrick Cy Woo
Hepatitis E virus (HEV) is the most common cause of acute viral hepatitis in China. Recently, a shift in molecular epidemiology from hepatitis E genotype 1 (HEV-1) to hepatitis E genotype 4 (HEV-4) has been observed in Northern China, marking a switch from human-to-human transmission to zoonosis. However, similar data from cities in Southern China are lacking. This observational study of human hepatitis E cases in Shenzhen, a metropolitan city in the Pearl River Delta region, aimed to describe the clinical features and molecular epidemiology of hepatitis E in Southern China...
December 20, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/29247673/tat-enhanced-delivery-of-the-c-terminus-of-hdag-l-inhibits-assembly-and-secretion-of-hepatitis-d-virus
#7
Hsiu-Chen Huang, Hsu-Feng Lu, Yu-Heng Lai, Chung-Pei Lee, Hui-Kang Liu, Cheng Huang
Hepatitis D virus (HDV) contains a single-stranded circular RNA genome that encodes two forms of hepatitis delta antigen (HDAg), the small delta antigen (HDAg-S) and the large delta antigen (HDAg-L). The two proteins have an identical amino acid sequence, except that HDAg-L has a 19-amino-acid extension at the C terminus. The domain spanning amino acid residues 198-210 of the HDAg-L (HDAg-L(198-210)) contains a nuclear export signal (NES), which is important for the nuclear export of HDV ribonucleoprotein to the cytoplasm...
December 14, 2017: Antiviral Research
https://www.readbyqxmd.com/read/29234199/prevalence-and-characteristics-of-hepatitis-delta-virus-infection-in-a-tertiary-hospital-setting-in-cameroon
#8
Henry N Luma, Servais A F B Eloumou, Cécile Okalla, Olivier Donfack-Sontsa, Ruth Koumitana, Agnes Malongue, Georges B Nko'Ayissi, Dominique N Noah
Background/Aims: Hepatitis B virus (HBV) and hepatitis D virus (HDV) coinfection is associated with more severe liver disease than HBV alone. More knowledge on the epidemiology and clinical impact of HDV-infected individuals is needed in Cameroon.We aimed at determining the frequency of anti-HDV antibody testing in hepatitis B surface antigen (HBsAg) positive patients, the proportion of anti-HDV positivity, and the characteristics of anti-HDV positive compared to anti-HDV negative patients in a tertiary hospital setting in Cameroon...
December 2017: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29217749/hepatitis-delta-virus-persists-during-liver-regeneration-and-is-amplified-through-cell-division-both-in-vitro-and-in-vivo
#9
Katja Giersch, Oliver D Bhadra, Tassilo Volz, Lena Allweiss, Kristoffer Riecken, Boris Fehse, Ansgar W Lohse, Joerg Petersen, Camille Sureau, Stephan Urban, Maura Dandri, Marc Lütgehetmann
OBJECTIVE: Hepatitis delta virus (HDV) was shown to persist for weeks in the absence of HBV and for months after liver transplantation, demonstrating the ability of HDV to persevere in quiescent hepatocytes. The aim of the study was to evaluate the impact of cell proliferation on HDV persistence in vitro and in vivo. DESIGN: Genetically labelled human sodium taurocholate cotransporting polypeptide (hNTCP)-transduced human hepatoma(HepG2) cells were infected with HBV/HDV and passaged every 7 days for 100 days in the presence of the entry inhibitor Myrcludex-B...
December 7, 2017: Gut
https://www.readbyqxmd.com/read/29212929/nucleic-acid-polymers-are-active-against-hepatitis-delta-virus-infection-in-vitro
#10
Frauke Beilstein, Matthieu Blanchet, Andrew Vaillant, Camille Sureau
In this study, an in vitro infection model for the hepatitis delta virus (HDV) was used to evaluate the antiviral effects of phosphorothioate nucleic acid polymers (NAPs) and investigate their mechanism of action. The results show that NAPs inhibit HDV infection at less than 4 micromolar concentrations in cultures of differentiated human hepatoma cells. NAPs were shown to be active at viral entry, but inactive post entry on HDV RNA replication. Inhibition was independent of the NAPs nucleotide sequence, but dependent on both size and amphipathicity of the polymer...
December 6, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29207996/crispr-cas9-mediated-gene-deletions-in-lager-yeast-saccharomyces-pastorianus
#11
Arthur R Gorter de Vries, Philip A de Groot, Marcel van den Broek, Jean-Marc G Daran
BACKGROUND: The ease of use of CRISPR-Cas9 reprogramming, its high efficacy, and its multiplexing capabilities have brought this technology at the forefront of genome editing techniques. Saccharomyces pastorianus is an aneuploid interspecific hybrid of Saccharomyces cerevisiae and Saccharomyces eubayanus that has been domesticated for centuries and is used for the industrial fermentation of lager beer. For yet uncharacterised reasons, this hybrid yeast is far more resilient to genetic alteration than its ancestor S...
December 5, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/29197497/delta-like-homolog1-gata-binding-protein-2-axis-mediates-leptin-inhibition-of-ppar%C3%AE-2-expression-in-hepatic-stellate-cells-in-vitro
#12
Yuanyuan Cheng, Xiaofei Zhu, Fangyun Cheng, Li Ji, Yajun Zhou
AIMS: Peroxisome-proliferator activated receptor γ (PPARγ) plays a pivotal role in inhibition of hepatic stellate cell (HSC) activation, a key step for liver fibrogenesis. Adipocyte-derived hormone leptin has been shown to promote liver fibrosis in murine and human. PPARγ includes two subtypes, PPARγ1 and PPARγ2. Our previous study indicated that leptin down-regulated PPARγ1 expression in HSCs. The aim of this study was to investigate the effect of leptin on PPARγ2 expression and the underlying mechanisms in HSCs...
November 29, 2017: Life Sciences
https://www.readbyqxmd.com/read/29190670/quantification-of-hbsag-to-predict-low-levels-and-seroclearance-in-hbeag-negative-patients-receiving-nucleos-t-ide-analogues
#13
Teresa Broquetas, Montserrat Garcia-Retortillo, Juan José Hernandez, Marc Puigvehí, Nuria Cañete, Susana Coll, Beatriz Cabrero, Maria Dolors Giménez, Ricard Solà, José A Carrión
BACKGROUND: HBeAg-negative chronic hepatitis B patients require long-term nucleos(t)ide analogues(NAs) because loss of surface antigen (HBsAg) is unusual. Low quantitative HBsAg (qHBsAg) levels can identify patients with higher probability of seroclearance. The aim of our study was to evaluate qHBsAg in HBeAg-negative patients receiving NAs to predict a reduction of HBsAg levels and seroclearance. METHODS: Retrospective analysis of qHBsAg in HBeAg-negative patients before and at years 1, 3, 5, 8 and over of NAs treatment...
2017: PloS One
https://www.readbyqxmd.com/read/29187686/-portal-systemic-encephalopathy-with-bilateral-thalamic-and-internal-capsule-lesions-using-diffusion-weighted-mri-in-a-super-aged-patient
#14
Michiaki Matsuda, Shinpei Takesako, Mitsuhiro Nakazaki, Toru Nandate, Fujio Umehara
We describe the case of a 90-year-old woman who was hospitalized in July 2016 and subsequently experienced a sudden decline in consciousness level resulting in a state of deep coma. Involuntary movements were not observed, and bilateral Babinski signs were inconclusive. Diffusion-weighted MRI (DWI) of the brain showed bilateral hyperintensity in the thalamus and internal capsule, laboratory testing detected high levels of plasma ammonia, and an electroencephalogram showed delta waves and triphasic waves predominantly in the frontal lobe...
November 28, 2017: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/29187150/identification-of-pathogens-for-differential-diagnosis-of-fever-with-jaundice-in-the-central-african-republic-a-retrospective-assessment-2008-2010
#15
Christelle Luce Bobossi Gadia, Alexandre Manirakiza, Gaspard Tekpa, Xavier Konamna, Ulrich Vickos, Emmanuel Nakoune
BACKGROUND: Febrile jaundice results clinically in generalized yellow coloration of the teguments and mucous membranes due to excess plasma bilirubin, accompanied by fever. Two types are found: conjugated and unconjugated bilirubin jaundice. Jaundice is a sign in several diseases due to viruses (viral hepatitis and arbovirus), parasites (malaria) and bacteria (leptospirosis). In the Central African Republic (CAR), only yellow fever is included on the list of diseases for surveillance...
November 29, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29186286/obesity-induced-changes-in-hepatic-and-placental-clock-gene-networks-in-rat-pregnancy
#16
Rachael C Crew, Brendan J Waddell, Peter J Mark
Maternal obesity induces pregnancy complications and disturbs fetal development, but the specific mechanisms underlying these outcomes are unclear. Circadian rhythms are implicated in metabolic complications associated with obesity, and maternal metabolic adaptations to pregnancy. Accordingly, obesity-induced circadian dysfunction may drive adverse outcomes in obese pregnancy. This study investigated whether maternal obesity alters the rhythmic expression of clock genes and associated nuclear receptors across maternal, fetal and placental tissues...
November 25, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29173205/effect-of-maternal-dyslipidaemia-on-the-cardiorespiratory-physiology-and-biochemical-parameters-in-male-rat-offspring
#17
Keyth Sulamitta L Guimarães, Emmanuel Veríssimo de Araújo, Jailane Souza Aquino, Danilo Assis Gadelha, Camille Moura Balarini, João Henrique Costa-Silva, Marciane Magnani, Hubert Vidal, Valdir Andrade Braga, José Luiz de Brito Alves
The present study evaluated the effects of maternal dyslipidaemia on blood pressure (BP), cardiorespiratory physiology and biochemical parameters in male offspring. Wistar rat dams were fed either a control (CTL) or a dyslipidaemic (DLP) diet during pregnancy and lactation. After weaning, both CTL and DLP offspring received standard diet. On the 30th and 90th day of life, blood samples were collected for metabolic analyses. Direct measurements of BP, respiratory frequency (RF), tidal volume (VT) and ventilation (VE) under baseline condition, as well as during hypercapnia (7 % CO2) and hypoxia (KCN, 0·04 %), were recorded from awake 90-d-old male offspring...
November 27, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/29162431/adenine-accelerated-the-diabetic-wound-healing-by-ppar-delta-and-angiogenic-regulation
#18
Jyh-Gang Leu, Ming-Hsing Chiang, Chao-Yi Chen, Jiun-Tsai Lin, Han-Min Chen, Yen-Lin Chen, Yao-Jen Liang
Wound healing is one of the major complications of diabetes, and problems with wound healing in diabetics often lead to amputation and even death. AMP-activated protein kinase (AMPK) is a protein involved in intracellular metabolism. Activated AMPK can reduce visceral fat and cholesterol synthesis and even inhibit hepatic gluconeogenesis. Activation of AMPK has been widely used in the treatment of type II diabetes. We applied an AMPK activator (Adenine) to human fibroblasts and to the wounds of streptozotocin-induced diabetic mice...
November 18, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29152762/optimizing-lonafarnib-treatment-for-the-management-of-chronic-delta-hepatitis-the-lowr-hdv-1-study
#19
Cihan Yurdaydin, Onur Keskin, Çağdaş Kalkan, Fatih Karakaya, Aysun Çalişkan, Ersin Karatayli, Senem Karatayli, A Mithat Bozdayi, Christopher Koh, Theo Heller, Ramazan Idilman, Jeffrey S Glenn
BACKGROUND AND RATIONALE: In a proof-of-concept (POC) study, the oral prenylation inhibitor lonafarnib (LNF) decreased HDV RNA during 4 weeks of treatment. Here we explored optimal LNF regimens. METHODS: 15 patients (5 groups; 3 per group) completed dosing as follows: 1) LNF 200 mg BID (12 weeks); 2) LNF 300 mg BID (12 weeks); 3) LNF 100 mg TID (5 weeks); 4) LNF 100 mg BID + pegylated interferon alfa (PEG-IFNα) 180 mcg QW (8 weeks); and 5) LNF 100 mg BID + ritonavir (RTV) 100 mg QD (8 weeks)...
November 20, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29134331/optimization-and-application-of-a-dna-launched-infectious-clone-of-equine-arteritis-virus
#20
Ting Qi, Xiaojun Wang
Reverse genetics is one of the most powerful tools in modern virology. Equine arteritis virus (EAV) is the prototype member of the Equartevirus. In this study, a new reverse genetics system for the recovery of equine arteritis virus from a cDNA plasmid, which contains viral cDNA sequence flanked by hammerhead ribozyme (HamRz) and hepatitis delta virus ribozyme (HdvRz) sequences in both terminals of the viral genome, was developed by optimization of the promoter and terminator regions. Cellular RNA polymerase II drove the transcription of the viral genome...
November 13, 2017: Applied Microbiology and Biotechnology
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