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Hepatitis delta

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https://www.readbyqxmd.com/read/28340836/effect-of-dosage-and-type-of-hepatitis-b-immunoglobulin-on-hepatitis-antibody-levels-in-liver-transplant-recipients
#1
A Ulku, A T Akcam, A Rencuzogullari, K Dalci, O Yalav, I C Eray, G Saritas
BACKGROUND: The current study aimed to evaluate the effect of dosage and type (intramuscular [IM] vs intravenous [IV]) of hepatitis B immunoglobulin (HBIG) on hepatitis antibody level in liver transplant recipients. METHODS: Between September 2000 and August 2016, patients who underwent orthotropic liver transplantation for chronic liver failure or hepatocellular carcinoma secondary to chronic hepatitis B virus (HBV) were retrospectively reviewed from a prospectively maintained database...
April 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28329027/prevalence-and-predictors-for-compensated-advanced-chronic-liver-disease-c-acld-in-patients-with-chronic-hepatitis-delta-virus-hdv-infection
#2
Ingrid Couto, Marilu Victoria, Valdiléa G Veloso, Lorena Rodrigues, Beatriz Grinsztejn, Marcus Lacerda, Flamir Victoria, Hugo Perazzo
OBJECTIVE: The study aimed to evaluate the prevalence and predictor factors for compensated advanced chronic liver disease (c-ACLD) in patients with hepatitis Delta virus (HDV) infection. METHODS: This cross-sectional study included consecutive HDV-infected patients defined by positive anti-HDV. Patients with hepatitis C coinfection, liver transplantation or presence of conditions that limit liver (LSM) or spleen stiffness measurement (SSM) were excluded. Blood tests, abdominal ultrasound, SSM and LSM by transient elastography (FibroScan®) were performed at the same day...
2017: PloS One
https://www.readbyqxmd.com/read/28320596/phillyrin-lowers-body-weight-in-obese-mice-via-the-modulation-of-ppar-beta-delta-angptl-4-pathway
#3
Hong-Bo Xiao, Guo-Guang Sui, Xiang-Yang Lu
OBJECTIVE: Previous investigations have shown that the peroxisome proliferator activated receptor beta/delta (PPAR<beta>/<delta>)-angiopoietin-like protein 4 (ANGPTL4) pathways may be a new pharmacologic target for treatment of obesity. The present study was conducted to test the effect of phillyrin, ‎a glucoside, on obesity in mice. METHOD: Fifty mice were randomly divided into 5 groups (n=10): control group (C57BL/6J mice), obese mice group, two groups of obese mice treated with phillyrin (15 or 45mg/kg/day), one group of obese mice treated with PPAR<beta>/<delta> agonist GW0742 (3mg/kg/day)...
March 17, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28267532/r2-relaxometry-of-the-pancreas-in-patients-with-human-hemochromatosis-protein-associated-hereditary-hemochromatosis
#4
B Henninger, S Rauch, H Zoller, M Plaikner, W Jaschke, C Kremser
PURPOSE: To evaluate pancreatic iron in patients with human hemochromatosis protein associated hereditary hemochromatosis (HHC) using R2* relaxometry. MATERIALS AND METHODS: 81 patients (58 male, 23 female; median age 49.5, range 10-81 years) with HHC were retrospectively studied. All underwent 1.5T magnetic resonance imaging (MRI) of the abdomen. A fat-saturated multi-gradient echo sequence with 12 echoes (TR=200ms; TE-initial 0.99ms; Delta-TE 1.41ms; 12 echoes; flip-angle: 20°) was used for the R2* quantification of the liver and the pancreas...
April 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28261291/the-prevalence-and-impact-of-brucellosis-in-patients-with-hepatitis-delta-virus-infection-inside-the-brucella-outbreak-with-cirrhosis
#5
Burak Suvak, Ahmet Cumhur Dulger, Ozlem Suvak, Aysun Özel Yesilyurt, Bilge Gultepe, Huseyin Guducuoglu
INTRODUCTION: Hepatitis D virus (HDV) infection is a serious health problem leading to cirrhosis and hepatocellular carcinoma (HCC). Despite evidence that zoonotic infections are associated with end-stage liver disease, brucellosis in patients with delta hepatitis related to liver disease has not been well characterized. So, we examined this relationship using recent hospital-based data. MATERIAL AND METHODS: We analyzed data from 96 delta hepatitis patients (mean age: 52...
March 1, 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28240840/liver-transplant-modulates-gut-microbial-dysbiosis-and-cognitive-function-in-cirrhosis
#6
Jasmohan S Bajaj, Andrew Fagan, Masoumeh Sikaroodi, Melanie B White, Richard K Sterling, HoChong Gilles, Douglas Heuman, R T Stravitz, Scott C Matherly, Mohammed S Siddiqui, Puneet Puri, Arun J Sanyal, Velimir Luketic, Binu John, Michael Fuchs, Vishwadeep Ahluwalia, Patrick M Gillevet
Liver transplant (LT) improves daily function and cognition in cirrhosis but a subset can remain impaired. Unfavorable microbiota or dysbiosis is observed in cirrhosis but the effect of LT on microbial composition; especially with poor post-LT cognition, is unclear. AIMS: (1) determine the effect of LT on gut microbiota and (b) to determine whether gut microbiota are associated with cognitive dysfunction post-LT. We enrolled outpatient cirrhotics on the LT list and followed them till 6 months post-LT...
February 27, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28223128/a-screening-assay-for-the-identification-of-host-cell-requirements-and-antiviral-targets-for-hepatitis-d-virus-infection
#7
Bettina Buchmann, Katinka Döhner, Thomas Schirdewahn, Beate Sodeik, Michael P Manns, Heiner Wedemeyer, Sandra Ciesek, Thomas von Hahn
Hepatitis delta virus (HDV) is a minimalistic satellite virus of hepatitis B virus (HBV). HBV/HDV co-infection, i.e. "hepatitis D", is the most severe form of viral hepatitis. No effective therapy for HDV infection is available partly due to the fact that HDV is a highly host-dependent virus devoid of any potentially drugable enzyme encoded in its small genome. In this study we present a semi-automated method to evaluate HDV infection and replication under the influence of different drugs. We utilized a Huh-7/hNTCP cell culture based system in a 96-well plate format, an automated microscope and image acquisition as well as analysis with the CellProfiler software to quantify the impact of these drugs on HDV infection...
May 2017: Antiviral Research
https://www.readbyqxmd.com/read/28199492/impact-of-tenofovir-on-hepatitis-delta-virus-replication-in-the-swiss-hiv-cohort-study
#8
Charles Béguelin, Nicole Friolet, Darius Moradpour, Roland Sahli, Franziska Suter-Riniker, Alexander Lüthi, Matthias Cavassini, Huldrych F Günthard, Manuel Battegay, Enos Bernasconi, Patrick Schmid, Alexandra Calmy, Andrew Atkinson, Andri Rauch, Gilles Wandeler
No abstract text is available yet for this article.
February 11, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28185139/rescue-of-a-recombinant-newcastle-disease-virus-strain-r2b-expressing-green-fluorescent-protein
#9
Madhan Mohan Chellappa, Sohini Dey, Satish Gaikwad, Dinesh C Pathak, Vikram N Vakharia
Newcastle disease virus (NDV), strain R2B is a mesogenic vaccine strain used for booster vaccination in chickens against Newcastle disease in India and many south East Asian countries. A full-length cDNA clone of the virus was generated by ligating eight overlapping fragments generated by reverse transcription polymerase chain reaction having unique restriction enzyme sites within them. This full-length cDNA clone was flanked by hammerhead ribozyme and hepatitis delta virus ribozyme sequences. Defined genetic markers were introduced into the NDV genome to differentiate the rescued virus from the parent virus...
February 9, 2017: Virus Genes
https://www.readbyqxmd.com/read/28159835/mir-135a-5p-mediated-downregulation-of-protein-tyrosine-phosphatase-receptor-delta-is-a-candidate-driver-of-hcv-associated-hepatocarcinogenesis
#10
Nicolaas Van Renne, Armando Andres Roca Suarez, Francois H T Duong, Claire Gondeau, Diego Calabrese, Nelly Fontaine, Amina Ababsa, Simonetta Bandiera, Tom Croonenborghs, Nathalie Pochet, Vito De Blasi, Patrick Pessaux, Tullio Piardi, Daniele Sommacale, Atsushi Ono, Kazuaki Chayama, Masashi Fujita, Hidewaki Nakagawa, Yujin Hoshida, Mirjam B Zeisel, Markus H Heim, Thomas F Baumert, Joachim Lupberger
BACKGROUND AND AIMS: HCV infection is a leading risk factor of hepatocellular carcinoma (HCC). However, even after viral clearance, HCC risk remains elevated. HCV perturbs host cell signalling to maintain infection, and derailed signalling circuitry is a key driver of carcinogenesis. Since protein phosphatases are regulators of signalling events, we aimed to identify phosphatases that respond to HCV infection with relevance for hepatocarcinogenesis. METHODS: We assessed mRNA and microRNA (miRNA) expression profiles in primary human hepatocytes, liver biopsies and resections of patients with HCC, and analysed microarray and RNA-seq data from paired liver biopsies of patients with HCC...
February 3, 2017: Gut
https://www.readbyqxmd.com/read/28141591/impact-of-interleukin-28b-rs12979860-c-t-polymorphism-on-severity-of-disease-and-response-to-treatment-in-hepatitis-delta
#11
Murat Ispiroglu, Ibrahim Halil Bahcecioglu, Ulvi Demirel, Mehmet Yalniz
INTRODUCTION: Pegylated-interferon alpha (Peg-IFN α) is the therapy most commonly used to treat chronic hepatitis delta virus (HDV) infection. In the present study, we planned to investigate effect of IL28B polymorphism on response to Peg-IFN α therapy and disease progression in patients with chronic HDV. METHODOLOGY: A total of 47 patients who received Peg-IFNα therapy for at least one year were investigated. The patients were divided into three groups based on their response to treatment: sustained viral response (SVR) (32%), unresponsive (53%), and relapse (15%)...
January 30, 2017: Journal of Infection in Developing Countries
https://www.readbyqxmd.com/read/28127203/3-dimensional-liver-volume-assessment-in-patients-with-hepatitis-b-virus-related-liver-cirrhosis-during-long-term-oral-nucleos-t-ide-analogues-therapy
#12
Chang Hun Lee, In Hee Kim, Jin Chang Moon, Seung Young Seo, Seong Hun Kim, Sang Wook Kim, Seung Ok Lee, Soo Teik Lee, Dae Ghon Kim, Jae Do Yang, Hee Chul Yu
AIM: To assess the effect of long-term oral nucleos(t)ide analogues (NUCs) therapy on liver volume change in patients with suppress hepatitis B virus (HBV)-related liver cirrhosis. METHODS: We reviewed the data of naïve patients with HBV-related liver cirrhosis, who had taken oral NUCs therapy, between 2003 and 2007 at Chonbuk University Hospital. We analyzed two consecutive sets of abdominal computerized tomography scans-one at the time of treatment initiation and another at the second-year follow-up...
January 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28126507/-hepatitis-delta-clinical-aspects-and-therapeutic-perspectives
#13
Dulce Alfaiate, Clothilde Miaglia, Fabien Zoulim
HDV prevalence must not be disregarded, as the virus is associated with a higher severity of hepatic disease. All HBV carriers should be tested for HDV as well, at least once during the disease history, and in case of worsening of a chronic HBV hepatitis. Diagnosis should rely on anti-HDV antibody testing, and confirmed by HDV RNA detection and quantification by RT-qPCR. The only treatment available is pegylated alpha interferon. Optimal duration of treatment has not yet been proven, and relapses are common...
January 23, 2017: La Presse Médicale
https://www.readbyqxmd.com/read/28121714/hepatitis-delta-and-hiv-infection
#14
Vincent Soriano, Kenneth E Sherman, Pablo Barreiro
Viral liver diseases are frequent comorbidities and major contributors to death in HIV-positive individuals on antiretroviral therapy. Although cure of hepatitis C and control of hepatitis B with antivirals avert liver disease progression in most HIV-coinfected patients, the lack of satisfactory treatment for hepatitis delta virus (HDV) infection remains a major threat for developing cirrhosis and liver cancer in this population. In the European Union (EU) and North America, sexual contact has replaced injection drug use that has been the major transmission route for HDV in HIV-positive persons...
April 24, 2017: AIDS
https://www.readbyqxmd.com/read/28109755/construction-of-agrobacterium-tumefaciens-mediated-tomato-black-ring-virus-infectious-cdna-clones
#15
Aleksandra Zarzyńska-Nowak, Inmaculada Ferriol, Bryce W Falk, Natasza Borodynko-Filas, Beata Hasiów-Jaroszewska
Tomato black ring virus (TBRV, genus Nepovirus) infects a wide range of economically important plants such as tomato, potato, tobacco and cucumber. Here, a successful construction of infectious full-length cDNA clones of the TBRV genomic RNAs (RNA1 and RNA2) is reported for the first time. The engineered constructs consisting of PCR-amplified DNAs were cloned into binary vector pJL89 immediately downstream of a double cauliflower mosaic virus (CaMV) 35S promoter, and upstream of the hepatitis delta virus (HDV) ribozyme and nopaline synthase terminator (NOS)...
January 18, 2017: Virus Research
https://www.readbyqxmd.com/read/28105258/efficacy-and-safety-of-tenofovir-in-chronic-hepatitis-b-australian-real-world-experience
#16
Grace C Lovett, Tin Nguyen, David M Iser, Jacinta A Holmes, Robert Chen, Barbara Demediuk, Gideon Shaw, Sally J Bell, Paul V Desmond, Alexander J Thompson
AIM: To evaluate the long-term treatment outcomes of tenofovir therapy in patients in a real world Australian tertiary care setting. METHODS: We performed a retrospective analysis of treatment outcomes among treatment-naïve and treatment-experienced patients receiving a minimum 3 mo tenofovir therapy through St Vincent's Hospital Melbourne, Australia. We included patients receiving tenofovir [tenofovir disoproxil fumarate (TDF)] monotherapy, as well as patients treated with TDF in combination with a second antiviral agent...
January 8, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28104130/recurrent-hepatitis-b-and-d-virus-infection-in-a-liver-transplant-recipient
#17
H Miyaaki, Y Tamada, K Hayashi, N Taura, S Miuma, H Shibata, A Soyama, M Hidaka, M Takatsuki, S Eguchi, K Nakao
Hepatitis B virus (HBV) and hepatitis delta virus (HDV) co-infections progress rapidly and lead to cirrhosis. In Japan, the prevalence of HBV and HDV co-infected patients is low. Therefore, there are few reports of patients with HBV and HDV co-infection having undergone liver transplantation. Herein, we report a rare case of recurrence of HBV and HDV in a 41-year-old man who underwent living donor liver transplantation 4 years prior.
January 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28098111/incidence-of-hepatitis-c-virus-seroconversion-among-hemodialysis-patients-in-the-nile-delta-of-egypt-a-single-center-study
#18
Amany Talaat Kamal, Mohamed Nazmy Farres, Abeer Mohamed Eissa, Naglaa Ahmed Arafa, Raafat Saad Abdel-Reheem
Egypt has the highest worldwide prevalence of hepatitis C virus (HCV) infection, caused in part by nosocomial transmission. Patients on hemodialysis (HD) are at especially high risk of infection. We aimed to estimate the incidence of seroconversion among HCV-negative patients undergoing regular HD at a unit in a large public hospital in the Nile Delta of Egypt, which implements the Egyptian Ministry of Health guidelines for infection control, and an isolation policy for hepatitis-positive patients. We also assessed the adherence to infection control practices and evaluated nurses and physicians' knowledge and attitude toward infection control procedures...
January 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28092214/treatment-of-delta-hepatitis-today-and-in-the-future-a-review
#19
REVIEW
Ibrahim Halil Bahcecioglu, Abdurrahman Sahin
Hepatitis delta virus (HDV) is a defective satellite virus and propagates in the presence of Hepatitis B virus (HBV) surface antigen (HBsAg). Approximately 5% of the people who infected with HBV are also infected with HDV. Chronic hepatitis caused by delta is the most severe form of chronic viral hepatitis including accelerated fibrosis, liver decompensation and development of hepatocellular carcinoma. Interferon-based therapies still remain the only treatment option of the hepatitis delta. The beneficiary effects of the interferon-based therapies, however, stop frequently with termination of the given therapy and relapse rate is very high...
April 2017: Infectious Diseases
https://www.readbyqxmd.com/read/28074227/heavy-metals-in-liver-and-brain-of-waterfowl-from-the-evros-delta-greece
#20
Maria Aloupi, Asimina Karagianni, Savas Kazantzidis, Triantaphyllos Akriotis
The concentrations of six heavy metals (cadmium [Cd], chromium [Cr], copper [Cu], manganese [Mn], lead [Pb], and zinc [Zn]) were determined in liver and brain of nine species of waterfowl from the Evros Delta, one of the most important wetlands in Greece, to assess metal contamination and potential risk to waterfowl. Significant differences among species were found for hepatic Cr, Cu, Pb, and Zn; the highest levels of all metals were found in liver of mute swans. Cd increased significantly with age in both organs of wigeon; some differences were also observed between males and females of the same species...
February 2017: Archives of Environmental Contamination and Toxicology
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