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https://www.readbyqxmd.com/read/28911778/applications-of-isotope-ratio-mass-spectrometry-in-sports-drug-testing-accounting-for-isotope-fractionation-in-analysis-of-biological-samples
#1
Thomas Piper, Mario Thevis
The misuse of anabolic-androgenic steroids (AAS) in sports aiming at enhancing athletic performance has been a challenging matter for doping control laboratories for decades. While the presence of a xenobiotic AAS or its metabolite(s) in human urine immediately represents an antidoping rule violation, the detection of the misuse of endogenous steroids such as testosterone necessitates comparably complex procedures. Concentration thresholds and diagnostic analyte ratios computed from urinary steroid concentrations of, e...
2017: Methods in Enzymology
https://www.readbyqxmd.com/read/28903836/reconsidering-a-lower-level-of-follicle-stimulating-hormone-as-abnormal-in-sub-fertile-males-of-pakistan
#2
Shehla Arif, Ayesha Khan
OBJECTIVE: To assess the association between Follicle-Stimulating Hormone (FSH) and semen parameters in order to evaluate whether the current laboratory reference for abnormal FSH levels should be readjusted. STUDY DESIGN: Observational, cross-sectional study. PLACE AND DURATION OF STUDY: Infertility Clinic of Gynecology Unit 1, Civil Hospital, Karachi, from May 2015 to April 2016. METHODOLOGY: The study included 100 sub-fertile males inducted from the clinic...
August 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28902623/chronic-endurance-exercise-antagonizes-the-cardiac-ucp2-and-ucp3-protein-up-regulation-induced-by-nandrolone-decanoate
#3
Gholamreza Bayat, Mohammad Javan, Azadeh Khalili, Fatemeh Safari, Saeed Shokri, Sohrab Hajizadeh
BACKGROUND: Several lines of evidence revealed that chronic treatment of anabolic androgenic steroids (AASs) is accompanied with some cardiovascular side effects and in addition they also negatively mask the beneficial effects of exercise training on cardiac performance. METHODS: The present study examined whether the nandrolone decanoate (ND)-induced cardiac effects were mediated by changing the cardiac uncoupling protein 2 (UCP2) and 3 (UCP3) expression. Five groups of male wistar-albino rats including sedentary control (SC), sedentary vehicle (SV), sedentary nandrolone decanoate (SND), exercise control (EC), and exercise nandrolone decanoate (END) were used...
September 13, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28891676/pornography-use-in-sexual-minority-males-associations-with-body-dissatisfaction-eating-disorder-symptoms-thoughts-about-using-anabolic-steroids-and-quality-of-life
#4
Scott Griffiths, Deborah Mitchison, Stuart B Murray, Jonathan M Mond
OBJECTIVE: We examined two hypotheses regarding the potential association of pornography use with body image-related and eating disorder-related psychopathology among sexual minority males (i.e. non-heterosexual males). Our primary hypothesis was that pornography use would be associated with males' body dissatisfaction, eating disorder symptoms, thoughts about using anabolic steroids and quality of life impairment; our secondary hypothesis was that the type of pornography, namely, professional versus amateur pornography, which contains idealised and non-idealised (i...
September 1, 2017: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/28877688/effects-of-hyaluronic-acid-combined-with-anti-inflammatory-drugs-compared-with-hyaluronic-acid-alone-in-clinical-trials-and-experiments-in-osteoarthritis-a-systematic-review-and-meta-analysis
#5
Thippaporn Euppayo, Veerasak Punyapornwithaya, Siriwadee Chomdej, Siriwan Ongchai, Korakot Nganvongpanit
BACKGROUND: The objectives are to compare the efficacy of intra-articular hyaluronic acid (IA-HA) alone and in combination with anti-inflammatory drugs (IA-HA + AI), corticosteroids (CS) or non-steroidal anti-inflammatory drugs (NSAIDs) in clinical trials and in vivo and in vitro studies of osteoarthritis (OA). METHODS: Data in the BIOSIS, CINAHL, Cochrane Library, EMBASE and Medline databases were collected and analyzed. Random effects models were used to compute the effect size (ES) of the mean difference in pain reduction scores from baseline and the relative risk (RR) of adverse events...
September 6, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28863033/increased-blood-pressure-and-aortic-stiffness-among-abusers-of-anabolic-androgenic-steroids-potential-effect-of-suppressed-natriuretic-peptides-in-plasma
#6
Jon J Rasmussen, Morten Schou, Per L Madsen, Christian Selmer, Marie L Johansen, Peter Hovind, Peter S Ulriksen, Jens Faber, Finn Gustafsson, Caroline Kistorp
BACKGROUND: Abuse of anabolic androgenic steroids (AAS) is prevalent among recreational athletes and adverse effects on blood pressure (BP) and arterial stiffness could be substantial. Testosterone decreases natriuretic peptides which are key components in BP-regulation and may impair BP-homeostasis in AAS abusers. OBJECTIVE: To investigate BP and aortic stiffness in relation to natriuretic peptides among current AAS abusers, former AAS abusers and controls. METHODS: In this cross-sectional study, 37 current AAS abusers, 33 former AAS abusers and 30 controls were included...
August 31, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28853020/illicit-drug-use-among-gym-goers-a-cross-sectional-study-of-gym-goers-in-sweden
#7
Yasmina Molero, Ann-Sofie Bakshi, Johanna Gripenberg
BACKGROUND: The use of anabolic-androgenic steroids has increased among gym-goers, and it has been proposed that this may be part of a polysubstance use pattern that includes the use of illicit drugs. Still, epidemiological data on illicit drug use among gym-goers of both genders are meager. The aim of the present study was thus to examine the use of illicit drugs and its correlates in a large sample of men and women who engaged in weight training at gyms across Sweden. METHODS: In this cross-sectional study, a total of 1969 gym-goers who engaged in weight training in 54 gyms across Sweden were invited to fill in a questionnaire...
August 29, 2017: Sports Medicine—Open
https://www.readbyqxmd.com/read/28842970/steroid-profile-and-irms-analysis-of-musk-administration-for-doping-control
#8
Jingzhu Wang, Yi He, Xin Liu, Zhiyong Yang, Wenning Yang
Musk, the dried secretion of the musk pod (sac) of adult male musk deer, has been used as traditional Chinese Medicine (TCM) in China and south-east Asian countries for thousands of years. Due to the anabolic steroid component in this TCM, musk preparations have been included in the list of medical products containing prohibited substances employed for doping by the State Food and Drug Administration of China. The application of musk pod formulation was claimed to be responsible for some adverse analytical findings (AAF) in the 2011 FIFA Women's World Cup...
August 25, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28832209/triceps-tendon-ruptures-a-systematic-review
#9
John C Dunn, Nicholas Kusnezov, Austin Fares, Sydney Rubin, Justin Orr, Darren Friedman, Kelly Kilcoyne
BACKGROUND: Triceps tendon ruptures (TTR) are an uncommon injury. The aim of this systematic review was to classify diagnostic signs, report outcomes and rerupture rates, and identify potential predisposing risk factors in all reported cases of surgical treated TTR. METHODS: A literature search collecting surgical treated cases of TTR was performed, identifying 175 articles, 40 of which met inclusion criteria, accounting for 262 patients. Data were pooled and analyzed focusing on medical comorbidities, presence of a fleck fracture on the preoperative lateral elbow x-ray film (Dunn-Kusnezov Sign [DKS]), outcomes, and rerupture rates...
September 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28822347/screening-and-confirmation-of-steroids-and-nitroimidazoles-in-urine-blood-and-food-matrices-sample-preparation-methods-and-liquid-chromatography-tandem-mass-spectrometric-separations
#10
Ádám Tölgyesi, Enikő Barta, Andrea Simon, Thomas J McDonald, Virender K Sharma
Veterinary drugs containing synthetic anabolic steroid and nitroimidazole active agents are not allowed for their applications in livestock of the European Union (EU). This paper presents analyses of twelve selected steroids and six nitroimidazole antibiotics at low levels (1.56μg/L-4.95μg/L and 0.17μg/kg-2.14μg/kg, respectively) in body fluids and egg incurred samples. Analyses involved clean-up procedures, high performance liquid chromatography (HPLC) separation, and tandem mass spectrometric screening and confirmatory methods...
October 25, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28817355/total-training-load-may-explain-similar-strength-gains-and-muscle-hypertrophy-seen-in-aged-rats-submitted-to-resistance-training-and-anabolic-steroids
#11
Walter Krause Neto, Wellington de Assis Silva, Adriano Polican Ciena, Danilo Bocalini, Ricardo Aparecido Baptista Nucci, Carlos Alberto Anaruma, Eliane Florencio Gama
This study aimed to quantify training parameters and analyze the morphological response of aged muscles submitted to resistance training and anabolic steroids. Aged Wistar rats were divided into groups: C - initial control; CF - final control; CAS - control with anabolic steroid, RT - resistance training, and RTA - resistance training with anabolic steroid. Maximum carried load, absolute and relative loads increased significantly in RT and RTA. RTA demonstrated greater relative load than RT. Average total volume, total climbing volume, relative total volume, relative total climbing volume, and mean climbing volume were similar between groups RT and RTA...
August 17, 2017: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/28811140/divergent-effects-of-resistance-training-and-anabolic-steroid-on-the-postsynaptic-region-of-different-skeletal-muscles-of-aged-rats
#12
Walter Krause Neto, Wellington de Assis Silva, Adriano Polican Ciena, Carlos Alberto Anaruma, Eliane Florencio Gama
This study aimed to analyze the effects of resistance training associated with testosterone administration in the neuromuscular junction (NMJ) postsynaptic region of different skeletal muscle types of aged rats. Wistar rats were divided into: SEI - 20-months-old control, SEF - 24-months-old control, T - 20-months-old with testosterone, S - 20-months-old resistance trained and ST - 20-months-old with resistance training associated with testosterone propionate. All groups were submitted to familiarization and maximum load carrying testing (MLCT)...
August 12, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28810407/intrasexual-competition-as-a-potential-influence-on-anabolic-androgenic-steroid-use-initiation
#13
Marc Harris, Michael Dunn, Tina Alwyn
An estimated 293,000 people living in the United Kingdom have used anabolic-androgenic steroids. However, there is currently no intervention to reduce usage available in practice or academic circulation throughout the United Kingdom. This study aimed to test a novel hypothesis that increased levels of intrasexual competition may play an important influential role in the use of anabolic-androgenic steroids. Significantly higher levels of intrasexual competition were evident in users compared to non-users but only in the novice group (0-2 years of experience)...
February 1, 2017: Journal of Health Psychology
https://www.readbyqxmd.com/read/28810404/sexual-orientation-bullying-for-being-labeled-gay-or-bisexual-and-steroid-use-among-us-adolescent-boys
#14
Mike C Parent, Tyler C Bradstreet
Use of anabolic-androgenic steroids is a public health concern for adolescent boys. This study examined bullying based on being labeled gay/bisexual and steroid use among US adolescent boys, including sexual orientation disparities. Data from 2660 boys from the 2015 Youth Behavior Risk Survey were used. Among heterosexual boys, steroid use was higher among those who reported being bullied due to being labeled gay or bisexual. No such relationship existed among non-heterosexual boys. The results speak to the need to address issues of masculinity in clinical work with boys and young men...
February 1, 2017: Journal of Health Psychology
https://www.readbyqxmd.com/read/28803647/determination-of-selected-endogenous-anabolic-androgenic-steroids-and-ratios-in-urine-by-ultra-high-performance-liquid-chromatography-tandem-mass-spectrometry-and-isotope-pattern-deconvolution
#15
J Pitarch-Motellón, J V Sancho, M Ibáñez, O Pozo, A F Roig-Navarro
An isotope dilution mass spectrometry (IDMS) method for the determination of selected endogenous anabolic androgenic steroids (EAAS) in urine by UHPLC-MS/MS has been developed using the isotope pattern deconvolution (IPD) mathematical tool. The method has been successfully validated for testosterone, epitestosterone, androsterone and etiocholanolone, employing their respective deuterated analogs using two certified reference materials (CRM). Accuracy was evaluated as recovery of the certified values and ranged from 75% to 108%...
August 3, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28777732/body-image-and-eating-disorders-are-common-among-professional-and-amateur-athletes-using-performance-and-image-enhancing-drugs-a-cross-sectional-study
#16
Daria Piacentino, Georgios D Kotzalidis, Livia Longo, Antonio Pavan, Luciano Stivali, Guido Stivali, Stefano Ferracuti, Roberto Brugnoli, Paola Frati, Vittorio Fineschi, Paolo Girardi, Gabriele Sani
The use of performance and image enhancing drugs (PIEDs) is not uncommon in athletes and appears to be associated with several psychopathological disorders of unclear prevalence. In this multicenter, cross-sectional study, we aimed to evaluate the prevalence of body image disorders (BIDs) and eating disorders (EDs) in PIED-using athletes vs. PIED nonusers. We enrolled 84 consecutive professional and amateur athletes training in sport centers in Italy, who underwent semi-structured interviews (SCID-I, SCID-II) and completed the Body Image Concern Inventory (BICI) and the Sick, Control, One, Fat, Food Eating Disorder Screening Test (SCOFF)...
August 4, 2017: Journal of Psychoactive Drugs
https://www.readbyqxmd.com/read/28743567/androgenic-anabolic-steroids-inhibited-post-exercise-hypotension-a-case-control-study
#17
Jefferson F C R Junior, Alexandre S Silva, Glêbia A Cardoso, Valmir O Silvino, Maria C C Martins, Marcos A P Santos
BACKGROUND: There is evidence of hypertensive effects caused by anabolic androgenic steroids (AAS). A single exercise session promotes the acute reduction of blood pressure, but the effects of AAS on this phenomenon are unknown. OBJECTIVES: To investigate the post-exercise blood pressure response in androgenic-anabolic steroid users. METHODS: Thirteen AAS users (23.9±4.3 years old) and sixteen controls (22.1±4.5 years old) performed a session of aerobic exercise...
July 11, 2017: Brazilian Journal of Physical Therapy
https://www.readbyqxmd.com/read/28738774/advanced-methods-for-analysis-of-testosterone
#18
Livia Alexandra Gugoasa, Raluca Ioana Stefan-van Staden
Testosterone is the principal endogenous androgenic-anabolic steroid in humans. The levels of testosterone in the human body are correlated with many hormonal disorders (hypogonadism, impotence, etc) mostly in men, and with many types of diseases such as: prostate cancer, metabolic syndrome, obesity, cardiovascular diseases and so on. Testosterone is extensively used among sportsmen willing to increase strength, aggressiveness, and recovery; making it the most commonly reported substance in steroid abuse. Fast, easy and cheap methods for the evaluation of testosterone are extremely needed in clinics and hospitals...
July 24, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28732133/ionization-and-collision-induced-dissociation-of-steroid-bis-glucuronides
#19
Argitxu Esquivel, Xavier Matabosch, Aristotelis Kotronoulas, Georgina Balcells, Jesús Joglar, Rosa Ventura
Studies on steroid metabolism are of utmost importance to improve the detection capabilities of anabolic androgenic steroids (AAS) misuse in sports drug testing. In humans, glucuronoconjugates are the most abundant phase II metabolites of AAS. Bis-glucuronidation is a reaction where two separated functional groups on the same molecule are conjugated with glucuronic acid. These metabolites have not been studied in depth for steroids and could be interesting markers for doping control. The aim of the present work was to study the ionization and collision induced dissociation of steroid bis-glucuronides to be able to develop mass spectrometric analytical strategies for their detection in urine samples after AAS administration...
July 21, 2017: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/28721347/peliosis-hepatis-complicating-pregnancy-a-rare-entity
#20
Muhammad Osama Butt, Nasir Hassan Luck, Syed Mujahid Hassan, Zaigham Abbas, Muhammed Mubarak
Peliosis hepatis (PH) is a rare, benign condition of the liver characterized by the presence of blood-filled lacunar spaces in the parenchyma. It usually has a chronic presentation and is a rare cause of portal hypertension reported in adult patients. Its etiology is diverse and ranges from infectious agents to tumors to toxic substances and anabolic steroids; however, the cause remains unclear in 25-50% of patients. Similarly, the symptomatology and imaging findings are diverse. Biopsy is the definitive test to diagnose the condition...
June 2017: Journal of Translational Internal Medicine
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