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https://www.readbyqxmd.com/read/29688324/determinants-of-long-term-clinical-outcomes-in-patients-with-angina-but-without-obstructive-coronary-artery-disease-a-systematic-review-and-meta-analysis
#1
Francesco Radico, Marco Zimarino, Fabio Fulgenzi, Fabrizio Ricci, Marta Di Nicola, Lasse Jespersen, Su Min Chang, Karin H Humphries, Mario Marzilli, Raffaele De Caterina
Aims: The long-term prognosis of angina in patients without obstructive coronary artery disease (CAD) is uncertain. To assess the incidence of long-term adverse outcomes in such patients. Methods and results: We searched PubMed, Cochrane Library, the Embase database, and the Clinical Trials Registry for studies published in English until January 2017, assessing the composite primary outcome of all-cause death and non-fatal myocardial infarction using random-effects models to estimate pooled incidences...
April 23, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29688209/-hybrid-intervention-for-an-atherosclerotic-lesion-of-arteries-of-the-iliofemoral-segment
#2
K A Kireev, A A Fokin, D V Rodnianskiĭ
The article describes a clinical case report regarding a successfully performed hybrid intervention in a patient presenting with critical ischaemia of a lower limb and an atherosclerotic lesion of arteries of the iliofemoral segment. Endovascular reconstruction in an isolated manner turned out to be impossible for both technical and anatomical reasons, whereas open reconstruction required two surgical accesses, an extended scope of the operation, and the use of a synthetic graft. Using a hybrid approach favourably contributed to adequate restoration of blood flow in the ischaemized limb, a decrease in the traumatic nature of the intervention, and also ensured angiographic control over the state of the operated arterial segment...
2018: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/29688198/-hybrid-surgical-treatment-of-a-multilevel-lesion-of-lower-limb-arteries
#3
P D Puzdriak, V V Shlomin, E A Shloĭdo, M A Ivanov, Iu P Didenko, I V Kas'ianov, P B Bondarenko, N Iu Grebenkina, T B Rakhmatillaev
The study was aimed at assessing immediate postoperative and remote results of hybrid surgical treatment of patients with a multilevel lesion of lower-limb arteries. Described herein is the authors' experience with simultaneous hybrid surgical management of 48 patients, including 43 subjects with a multilevel lesion of arteries of the lower extremities. There were 40 men and 8 women, with the average age amounting to 65.8±7.9 years. Of these, 30 patients suffered from stage II-b chronic arterial insufficiency (CAI), 11 had stage III CAI and 7 had stage IV CAI according to A...
2018: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/29688190/-present-day-possibilities-of-non-invasive-control-over-microcirculation-and-metabolism-in-man
#4
A A Fedorovich, A G Bagdasarian, I G Uchkin, G N Soboleva, S A Boĭtsov
The main function of the microcirculatory bed consists in maintaining tissue homeostasis at an optimal level irrespective of the effect of various external and internal factors. Of all types of metabolism (diffusive, filtration-reabsorption and vesicular), directly dependent on the haemodynamic parameters is filtration-reabsorption metabolism which provides exchange of water, low-molecular-weight and water-soluble substances at the opposite to the heart «pole» of the cardiovascular system. The present study was aimed at testing a hypothesis that activation of metabolic processes in man would be accompanied by alterations in haemodynamic parameters which may be registered by means of modern non-invasive methods of examination, i...
2018: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/29684674/natural-products-targeting-er-stress-pathway-for-the-treatment-of-cardiovascular-diseases
#5
REVIEW
Ker Woon Choy, Dharmani Murugan, Mohd Rais Mustafa
Endoplasmic reticulum (ER) is the main organelle for the synthesis, folding, and processing of secretory and transmembrane proteins. Pathological stimuli including hypoxia, ischaemia, inflammation and oxidative stress interrupt the homeostatic function of ER, leading to accumulation of unfolded proteins, a condition referred to as ER stress. ER stress triggers a complex signalling network referred as the unfolded protein response (UPR). Extensive studies have demonstrated that ER stress plays an important role in the pathogenesis of various cardiovascular diseases such as heart failure, ischemic heart disease and atherosclerosis...
April 20, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29680175/three-year-patency-and-recurrence-rates-of-revision-using-distal-inflow-with-a-venous-interposition-graft-for-high-flow-brachial-artery-based-arteriovenous-fistula
#6
Michael W M Gerrickens, Roel H D Vaes, Bastiaan Govaert, Magda van Loon, Jan H M Tordoir, Frank van Hoek, Joep A W Teijink, Marc R Scheltinga
OBJECTIVES: Upper arm arteriovenous fistulas (AVF) occasionally develop high flow. Revision using distal inflow (RUDI) effectively reduces flow of high flow accesses (HFA) in the short-term and is also popularised for treatment of haemodialysis access induced distal ischaemia (HAIDI). The long-term efficacy is unknown. The study's aim was to report on 3 year RUDI patency and recurrence rates for HFA with and without HAIDI. MATERIAL AND METHODS: This was a retrospective cohort study of patients with a HFA with or without HAIDI undergoing RUDI using greater saphenous vein (GSV) interposition between March 2011 and October 2017 at three facilities...
April 18, 2018: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29679638/inhibition-of-immunoproteasome-promotes-angiogenesis-via-enhancing-hypoxia-inducible-factor-1%C3%AE-abundance-in-rats-following-focal-cerebral-ischaemia
#7
Xingyong Chen, Xu Zhang, Ting Chen, Xiulong Jiang, Xiaosong Wang, Huixin Lei, Yinzhou Wang
Angiogenesis after ischemic stroke contributes to the restoration of blood supply in the ischemic zone. Strategies to improve angiogenesis may facilitate the function recovery after stroke. Growing evidence shows that proteasome inhibitors enhance angioneurogenesis and induces a long-term neuroprotection after cerebral ischemia in rodents' models. We have previously reported that inhibition of the immunoproteasome subunit low molecular mass peptide 2 (LMP2) offers a strong neuroprotection in ischemic stroke rats...
April 18, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29678775/involvement-of-gap-junctions-in-astrocyte-impairment-induced-by-manganese-exposure
#8
Cailing Lu, Zhijuan Meng, Yiyuan He, Deqiang Xiao, Haiqing Cai, Yilu Xu, Xianghong Liu, Xinhang Wang, Laiming Mo, Ziwei Liang, Xuejing Wei, Qingqing Ao, Boying Liang, Xiyi Li, Shen Tang, Songchao Guo
Glutamate excitotoxicity, characterized as excessive glutamate stress, is considered to be involved in cerebral ischaemia, brain trauma, and neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease. Glutamate homeostasis disruption was highlighted in Mn neurotoxicity caused by high levels of Mn. Astrocytes, accounting for approximately 50% of the neuronal cells in the central nervous system and maintain glutamate homeostasis, are sensitive to neurotoxicity induced by Mn exposure. Astrocytes are tightly coupled with gap junctions (GJ), which are comprised of connexins, mainly connexin43 (Cx43)...
April 17, 2018: Brain Research Bulletin
https://www.readbyqxmd.com/read/29678502/monitoring-of-glycolytic-activity-secondary-to-ischaemia-in-knee-replacement-surgery
#9
V J León-Muñoz, A J Lisón-Almagro, C H Hernández-García, M López-López
OBJECTIVES: To non-invasively assess tissue lesion secondary to ischaemia applied during knee replacement surgery. Secondary objectives: to assess whether this lesion correlates with the duration of ischaemia and whether instrumental and gender variables influence it. MATERIAL AND METHODS: Prospective cohort study. Pre and postoperative serum lactate levels have been determined as an indicator of glycolytic activity secondary to ischaemia in 88 patients. Serum lactate determination was performed by reactive strips of enzymatic-amperometric detection on capillary blood...
April 17, 2018: Revista Española de Cirugía Ortopédica y Traumatología
https://www.readbyqxmd.com/read/29676052/rapamycin-protects-against-early-brain-injury-independent-of-cerebral-blood-flow-changes-in-a-mouse-model-of-subarachnoid-haemorrhage
#10
Kazumasu Sasaki, Shuzo Yamamoto, Tatsushi Mutoh, Yoshiharu Tsuru, Yasuyuki Taki, Ryuta Kawashima
We evaluated the neuroprotective role of rapamycin, a mammalian target of rapamycin (mTOR) kinase inhibitor, in cerebral ischaemia and locomotor function in a mouse model of subarachnoid haemorrhage (SAH). Pretreatment with rapamycin, a mTOR kinase inhibitor, resulted in better recovery from cerebral hypoxia early after SAH than control (P < .05), while the values of peak flow velocity in the middle cerebral artery did not change significantly (P > .05). The ratio of central-area distance/total travelled distance determined by open-field test after day 14 was significantly higher in mice pretreated with rapamycin than in control mice (P < ...
April 19, 2018: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29674360/retrospective-observational-study-of-emergency-department-syndromic-surveillance-data-during-air-pollution-episodes-across-london-and-paris-in-2014
#11
Helen E Hughes, Roger Morbey, Anne Fouillet, Céline Caserio-Schönemann, Alec Dobney, Thomas C Hughes, Gillian E Smith, Alex J Elliot
INTRODUCTION: Poor air quality (AQ) is a global public health issue and AQ events can span across countries. Using emergency department (ED) syndromic surveillance from England and France, we describe changes in human health indicators during periods of particularly poor AQ in London and Paris during 2014. METHODS: Using daily AQ data for 2014, we identified three periods of poor AQ affecting both London and Paris. Anonymised near real-time ED attendance syndromic surveillance data from EDs across England and France were used to monitor the health impact of poor AQ...
April 19, 2018: BMJ Open
https://www.readbyqxmd.com/read/29672718/mineralocorticoid-receptor-antagonists-in-kidney-transplantation-time-to-consider
#12
Sophie Girerd, Frédéric Jaisser
Although patient survival is significantly improved by kidney transplantation (KT) in comparison with dialysis, it remains significantly lower than that observed in the general population. Graft function is one of the major determinants of patient survival after KT. Mineralocorticoid receptor antagonists (MRAs) could be of particular interest in this population to improve graft function and treat or prevent cardiovascular (CV) complications. In KT, ischaemia/reperfusion injury is a major factor involved in delayed graft function, which is often associated with inferior long-term graft survival...
April 17, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29671939/synthetic-cpg-oligonucleotides-induce-a-genetic-profile-ameliorating-murine-myocardial-i-r-injury
#13
Tobias Hilbert, Paul Markowski, Stilla Frede, Olaf Boehm, Pascal Knuefermann, Georg Baumgarten, Andreas Hoeft, Sven Klaschik
We previously demonstrated that pre-conditioning with CpG oligonucleotide (ODN) 1668 induces quick up-regulation of gene expression 3 hours post-murine myocardial ischaemia/reperfusion (I/R) injury, terminating inflammatory processes that sustain I/R injury. Now, performing comprehensive microarray and biocomputational analyses, we sought to further enlighten the "black box" beyond these first 3 hours. C57BL/6 mice were pretreated with either CpG 1668 or with control ODN 1612, respectively. Sixteen hours later, myocardial ischaemia was induced for 1 hour in a closed-chest model, followed by reperfusion for 24 hours...
April 19, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29668855/the-negative-ultraslow-potential-electrophysiological-correlate-of-infarction-in-the-human-cortex
#14
Janos Lückl, Coline L Lemale, Vasilis Kola, Viktor Horst, Uldus Khojasteh, Ana I Oliveira-Ferreira, Sebastian Major, Maren K L Winkler, Eun-Jeung Kang, Karl Schoknecht, Peter Martus, Jed A Hartings, Johannes Woitzik, Jens P Dreier
Spreading depolarizations are characterized by abrupt, near-complete breakdown of the transmembrane ion gradients, neuronal oedema, mitochondrial depolarization, glutamate excitotoxicity and activity loss (depression). Spreading depolarization induces either transient hyperperfusion in normal tissue; or hypoperfusion (inverse coupling = spreading ischaemia) in tissue at risk for progressive injury. The concept of the spreading depolarization continuum is critical since many spreading depolarizations have intermediate characteristics, as opposed to the two extremes of spreading depolarization in either severely ischaemic or normal tissue...
April 16, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29666943/the-gtn-patch-a-simple-and-effective-new-approach-to-cardioprotection
#15
Derek M Yellon, Zhenhe He, Rayomand Khambata, Amrita Ahluwalia, Sean M Davidson
There remains a significant un-met need to reduce the extent of myocardial injury caused by ischaemia and reperfusion injury in patients experiencing an ST-elevation MI. Although nitric oxide is central to many cardioprotective strategies currently undergoing investigation, cardioprotection from the delivery of nitrates/nitrites has been inconsistently observed. The route of administration appears to be a critical variable. The glyceryl trinitrate (GTN) patch is commonly used as a simple and practical means of delivering nitric oxide to patients with ischaemic heart disease, but whether acute cardioprotection can be achieved by application of a GTN patch has not been investigated before...
April 17, 2018: Basic Research in Cardiology
https://www.readbyqxmd.com/read/29665191/the-impact-of-donor-body-mass-index-on-outcomes-after-deceased-kidney-transplantation
#16
Adam Arshad, James Hodson, Imogen Chappelow, Nicholas G Inston, Andrew R Ready, Jay Nath, Adnan Sharif
The aim of this study was to determine the effect of donor body mass index (BMI) on deceased-donor kidney transplant outcomes. Data were collected from the UK Transplant Registry for all deceased-donor kidney transplant recipients between January 2003 and January 2015. Univariable and multivariable analyses were undertaken to assess the impact of donor BMI on a range of outcomes. Donor BMI (kg/m2 ) was stratified as <18.5 (n=380), 18.5-25.0 (n=6890), 25.1-30.0 (n=6669), 30.1-35.0 (n=2503) and >35.0 (n=1148)...
April 17, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29665013/planhab-hypoxia-does-not-worsen-the-impairment-of-skeletal-muscle-oxidative-function-induced-by-bed-rest-alone
#17
Desy Salvadego, Michail E Keramidas, Roger Kölegård, Lorenza Brocca, Stefano Lazzer, Irene Mavelli, Jörn Rittweger, Ola Eiken, Igor B Mekjavic, Bruno Grassi
KEY POINTS: Superposition of hypoxia on 21 day bed rest did not worsen the impairment of skeletal muscle oxidative function induced by bed rest alone. A significant impairment of maximal oxidative performance was identified downstream of cardiovascular O2 delivery, involving both the intramuscular matching between O2 supply and utilization and mitochondrial respiration. These chronic adaptations appear to be relevant in terms of exposure to spaceflights and reduced gravity habitats (Moon or Mars), as characterized by low gravity and hypoxia, in patients with chronic diseases characterized by hypomobility/immobility and hypoxia, as well as in ageing...
April 17, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29664117/perioperative-hyperoxia-and-post-operative-cardiac-complications-in-adults-undergoing-non-cardiac-surgery-systematic-review-protocol
#18
REVIEW
C Petersen, J Wetterslev, C S Meyhoff
BACKGROUND: Oxygen therapy is used liberally for all patients undergoing anaesthesia. Recent studies have raised concerns that it may not be without complications when arterial oxygen concentrations reach supranormal concentrations (hyperoxia). Studies of oxygen therapy have raised concerns that the risk of myocardial injury and infarction is elevated in patients with hyperoxia due to vasoconstriction and formation of reactive oxygen species. Due to lack of symptoms or silent ischaemia, post-operative myocardial injury may be missed clinically...
April 17, 2018: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/29663176/serum-magnesium-and-risk-of-incident-heart-failure-in-older-men-the-british-regional-heart-study
#19
Sasiwarang Goya Wannamethee, Olia Papacosta, Lucy Lennon, Peter H Whincup
To examine the association between serum magnesium and incident heart failure (HF) in older men and investigate potential pathways including cardiac function, inflammation and lung function. Prospective study of 3523 men aged 60-79 years with no prevalent HF or myocardial infarction followed up for a mean period of 15 years, during which 268 incident HF cases were ascertained. Serum magnesium was inversely associated with many CVD risk factors including prevalent atrial fibrillation, lung function (FEV1 ) and markers of inflammation (IL-6), endothelial dysfunction (vWF) and cardiac dysfunction [NT-proBNP and cardiac troponin T (cTnT)]...
April 17, 2018: European Journal of Epidemiology
https://www.readbyqxmd.com/read/29660909/the-effect-of-trimetazidine-in-reducing-the-ischemia-reperfusion-injury-in-rat-epigastric-skin-flaps
#20
Laura Petrovics, Tibor Nagy, Peter Hardi, Laura Bognar, Gabor Pavlovics, Gyorgy Tizedes, Ildiko Takacs, Gabor Jancso
BACKGROUND: Ischemia-reperfusion injury may lead to insufficient microcirculation and results in partial flap loss during the free flap surgeries. OBJECTIVE: This study aimed to investigate the effect of trimetazidine (TMZ) on oxidative stress, inflammation and histopathological changes, using the epigastric skin flap model in rats. METHODS: 40 male Wistar rats were used, that were divided into four groups. Control group, non-treated ischemic (I/R)-group and two trimetazidine treated groups (preischemically, postischemically) were established...
April 13, 2018: Clinical Hemorheology and Microcirculation
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