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https://www.readbyqxmd.com/read/29924788/-results-of-hybrid-loop-endarterectomy-from-the-superficial-femoral-artery-with-the-multitasc
#1
E R Lysenko, A S Azarian, O G Griaznov, A V Amirova, E V Bushueva, A V Troitskiĭ
The purpose of this study was to analyse the results of hybrid loop endarterectomy from the superficial femoral artery (SFA) in its occlusion, preformed in a total of forty-two patients. Of these, 27 patients had prior to the intervention been diagnosed with stage II B ischaemia and 15 patients had been diagnosed as having critical ischaemia. Technical success of the operation amounted to 88%, with the frequency of early thromboses equalling 2.7%. In the early postoperative period, one patient died of acute myocardial infarction...
2018: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/29924784/-in-hospital-outcomes-of-reconstructive-interventions-on-the-aortofemoral-segment-in-patients-with-multifocal-atherosclerosis
#2
N N Burkov, A N Kazantsev, R S Tarasov
The purpose of the study was to analyse the in-hospital results of surgical treatment in a total of 275 patients presenting with atherosclerotic occlusive and stenotic lesions of the aortofemoral segment within the framework of a single-centre prospective register. The authors performed a detailed analysis of prognostic significance of a wide spectrum of clinico-instrumental, anatomo-angiographic and perioperative factors, followed by revealing the causes of an unfavourable prognosis during the in-hospital period...
2018: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/29924774/-contrast-enhanced-ultrasonographic-study-in-patients-with-lower-limb-arterial-lesions
#3
I E Timina, N N Askerova, G G Karmazanovskiĭ, I I Piatkova, A E Zotikov
BACKGROUND: The introduction into clinical practice of contrast-enhanced ultrasonographic examination made it possible to assess patency of tibial arteries and perfusion of crural muscles in patients with occlusive lesions of lower-limb arteries. These findings are important for planning optimal treatment policy and assessing efficacy of operative or medicamentous treatment. OBJECTIVE: The study was aimed at investigating a possibility of contrast-enhanced ultrasound examination for assessment of patency of tibial arteries and quantitative assessment of perfusion of crural muscles in patient with occlusive lesions of lower-limb arteries...
2018: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/29924773/-gene-mediated-induction-of-angiogenesis-in-inoperable-patients-with-atherosclerosis-and-diabetes-mellitus
#4
R E Kalinin, I A Suchkov, R V Deev, N D Mzhavanadze, A A Krylov
Analysed in the article are the results of a comprehensive approach to treatment of patients presenting with lower limb critical ischaemia and diabetes mellitus by means of gene-induced angiogenesis. The study comprised a total of 65 patients found to have an ill-suited for surgical reconstruction peripheral arterial bed and undergoing conservative therapy. The patients were divided into two groups. The Study Group patients additionally to the conventional conservative therapy received 2 intramuscular injections of therapeutic agent Neovasculgen at a course dose of 2...
2018: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/29924772/-biological-aspects-and-clinical-application-of-bone-marrow-stem-cells-in-critical-lower-limb-ischaemia
#5
P Iu Orekhov, A V Troitskiĭ, A V Chupin
Critical lower-limb ischaemia (CLLI) is associated with high risk of limb loss and a lethal outcome, as well as with decreased quality of life. The underlying cause of the disease is imbalance between blood supply of ischaemized tissues and their metabolic demands. Restoration of adequate perfusion with the help of standard medicamentous therapy or operative treatment is often inefficient or impossible. Cell therapy (CT) is a novel strategy making it possible to stimulate the growth of the microvascular bed and the mechanisms of molecular-cellular repair...
2018: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/29922725/management-of-lower-extremity-ischaemia-during-type-a-dissection-repair
#6
Kathryn L Howe, John Harlock, Dominic Parry
Introduction: Type A aortic dissection can present with malperfusion syndrome. Lower limb ischaemia may resolve with repair of the dissection; however, the long duration of repair and/or persistent ischaemia may leave tissue at risk of necrosis with potential for substantial morbidity. Report: Here, the case of a 67 year old man who presented with a Type A aortic dissection with malperfusion of the lower extremities is described. The Vascular Surgery and Cardiac Surgery divisions were consulted simultaneously...
2018: EJVES Short Reports
https://www.readbyqxmd.com/read/29921218/a-comparison-of-lkb1-ampk-mtor-metabolic-axis-response-to-global-ischaemia-in-brain-heart-liver-and-kidney-in-a-rat-model-of-cardiac-arrest
#7
Shohreh Majd, John H T Power, Timothy K Chataway, Hugh J M Grantham
BACKGROUND: Cellular energy failure in high metabolic rate organs is one of the underlying causes for many disorders such as neurodegenerative diseases, cardiomyopathies, liver and renal failures. In the past decade, numerous studies have discovered the cellular axis of LKB1/AMPK/mTOR as an essential modulator of cell homeostasis in response to energy stress. Through regulating adaptive mechanisms, this axis adjusts the energy availability to its demand by a systematized control on metabolism...
June 19, 2018: BMC Cell Biology
https://www.readbyqxmd.com/read/29921042/cardioprotection-of-ischaemic-preconditioning-is-associated-with-inhibition-of-translocation-of-mlkl-within-the-plasma-membrane
#8
Adrián Szobi, Veronika Farkašová-Ledvényiová, Martin Lichý, Martina Muráriková, Slávka Čarnická, Tatiana Ravingerová, Adriana Adameová
Necroptosis, a form of cell loss involving the RIP1-RIP3-MLKL axis, has been identified in cardiac pathologies while its inhibition is cardioprotective. We investigated whether the improvement of heart function because of ischaemic preconditioning is associated with mitigation of necroptotic signaling, and these effects were compared with a pharmacological antinecroptotic approach targeting RIP1. Langendorff-perfused rat hearts were subjected to ischaemic preconditioning with or without a RIP1 inhibitor (Nec-1s)...
June 19, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29921037/hydrogen-gas-inhalation-protects-against-cutaneous-ischaemia-reperfusion-injury-in-a-mouse-model-of-pressure-ulcer
#9
Wei Fang, Guizhen Wang, Luyan Tang, Huilin Su, Huyan Chen, Wanqing Liao, Jinhua Xu
Pressure ulcer formation depends on various factors among which repetitive ischaemia/reperfusion(I/R) injury plays a vital role. Molecular hydrogen (H2 ) was reported to have protective effects on I/R injuries of various internal organs. In this study, we investigated the effects of H2 inhalation on pressure ulcer and the underlying mechanisms. H2 inhalation significantly reduced wound area, 8-oxo-dG level (oxidative DNA damage) and cell apoptosis rates in skin lesions. H2 remarkably decreased ROS accumulation and enhanced antioxidant enzymes activities by up-regulating expression of Nrf2 and its downstream components in wound tissue and/or H2 O2 -treated endothelia...
June 19, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29920851/a-unified-model-of-the-excitability-of-mouse-sensory-and-motor-axons
#10
Preet G S Makker, José Manuel Matamala, Susanna B Park, Justin G Lees, Matthew C Kiernan, David Burke, Gila Moalem-Taylor, James Howells
Non-invasive nerve excitability techniques have provided valuable insight into the understanding of neurological disorders. The widespread use of mice in translational research on peripheral nerve disorders and by pharmaceutical companies during drug development requires valid and reliable models that can be compared to humans. This study established a novel experimental protocol that enables comparative assessment of the excitability properties of motor and sensory axons at the same site in mouse caudal nerve, compared the mouse data to data for motor and sensory axons in human median nerve at the wrist, and constructed a mathematical model of the excitability of mouse axons...
June 19, 2018: Journal of the Peripheral Nervous System: JPNS
https://www.readbyqxmd.com/read/29917246/protective-effect-of-tadalafil-and-verapamil-on-testicular-function-and-oxidative-stress-after-torsion-detorsion-in-adult-male-rat
#11
Mojtaba Ameli, Mohaddeseh Sadat Hashemi, Maryam Moghimian, Majid Shokoohi
OBJECTIVE: This study used a rat model to investigate the protective effect of tadalafil and verapamil on testicular function and oxidative stress after torsion/detorsion. METHODS AND MATERIALS: Animals were randomly divided into five groups: G1, Sham group; G2, testicular torsion followed by detorsion (TD); G3, testicular torsion/detorsion received 0/4 mg/kg of tadalafil (TDT); G4, testicular torsion/detorsion received 0/1 mg/kg of verapamil (TDV); and G5, testicular torsion/detorsion received 0/1 mg/kg of verapamil and 0/4 mg/kg of tadalafil (TDTV)...
June 19, 2018: Andrologia
https://www.readbyqxmd.com/read/29917121/new-insights-into-spinal-cord-ischaemia-after-thoracic-aortic-procedures-the-importance-of-the-number-of-anterior-radiculomedullary-arteries-for-surgical-outcome
#12
Fabian A Kari, Babak Saravi, Sonja Krause, Luisa Puttfarcken, Johannes Scheumann, Katharina Förster, Bartosz Rylski, Sven Maier, Ulrich Göbel, Matthias Siepe, Martin Czerny, Friedhelm Beyersdorf
OBJECTIVES: Anterior radiculomedullary arteries (ARMAs) link dorsal segmental arteries and the intraspinal compartment of the spinal collateral network. The number of thoracic ARMA is highly variable from one person to another. The impact of the number of ARMAs on spinal cord perfusion during thoracic aortic procedures is unknown. We investigated the influence of the number of thoracic ARMAs on spinal cord perfusion in an aortic surgical large animal model. METHODS: Twenty-six pigs were included (20 treatment animals, 6 sham animals, weight 34 ± 3 kg)...
July 1, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29914695/sensitivity-analysis-of-st-segment-epicardial-potentials-arising-from-changes-in-ischaemic-region-conductivities-in-early-and-late-stage-ischaemia
#13
Barbara M Johnston, Peter R Johnston
Although computational studies are increasingly used to gain insight into diseases such as myocardial ischaemia, there is still considerable uncertainty about the values for many of the parameters in these studies. This is particularly true for the bidomain conductivity values that are used in normal tissue and, even more so, in ischaemic tissue, when modelling ischaemia. In this work, we extended a previous study that used a half-ellipsoidal model and a realistic model to study subendocardial ischaemia during the ST segment, so that we could simulate both early and late stage ischaemia...
June 15, 2018: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29912599/the-impact-of-nuchal-cord-on-umbilical-cord-blood-gas-analysis-and-ischaemia-modified-albumin-levels-in-elective-c-section
#14
Aslı Yarcı Gursoy, Burcin Ozgu, Yasemin Tasci, Tuba Candar, Salim Erkaya, Gamze Sinem Caglar
This study was designed to evaluate umbilical cord ischaemia-modified albumin (IMA) levels and the cord blood gas parameters of foetuses with or without nuchal cords, at the time of elective C-section. The cross-sectional study population consisted of the patients who were admitted to the Tertiary Care Center between February and June 2015. Women with uncomplicated single term gestations between 37 and 40 completed weeks and scheduled for elective C-sections were included in the study. Fifty cases with a nuchal cord and 50 cases without a nuchal cord were recruited...
June 18, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29912386/impairment-of-the-akt-pathway-in-transplanted-type-1-diabetic-hearts-is-associated-with-post-transplant-graft-injury
#15
Sevil Korkmaz-Icöz, Shiliang Li, Sivakkanan Loganathan, Tamás Radovits, Mihály Ruppert, Paige Brlecic, Alex Ali Sayour, Gábor Veres, Thomas Fleming, Maik Brune, Patrick Most, Matthias Karck, Gábor Szabó
OBJECTIVES: The use of 'marginal' hearts, such as from donors with diabetes mellitus (DM), could offer an opportunity to expand the donor pool in cardiac transplantation. Previous studies have shown that the phosphatidylinositol-3-kinase (PI3K)/Akt pathway is altered after ischaemia/reperfusion injury in the diabetic myocardium. We hypothesized that DM-induced cardiac dysfunction in donors is further impaired after heart transplantation and that PI3K/Akt-pathway alterations may be one of the underlying pathomechanisms...
June 14, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29909663/an-innovative-way-of-managing-coeliac-artery-stenosis-during-pancreaticoduodenectomy
#16
S Balakrishnan, S Kapoor, P Vijayanath, H Singh, A Nandhakumar, K Venkatesulu, V Shanmugam
Coeliac artery stenosis (CAS) is rarely of consequence owing to rich collateral supply from the superior mesenteric artery via the pancreatic head. Pancreaticoduodenectomy (PD) in CAS disrupts these collaterals, and places the liver, stomach and spleen at risk of ischaemia. A 56-year-old man presented with a 3-week history of obstructive jaundice. Computed tomography revealed an operable periampullary tumour with CAS due to compression by the median arcuate ligament with multiple collaterals in the pancreatic head and a prominent gastroduodenal artery (GDA)...
June 18, 2018: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/29909384/common-femoral-artery-aneurysm-repair-using-bifurcated-graft
#17
Sesi Ayodele Hotonu, Charles Henry North Johnson, Nisheeth Kansal, Vish Bhattacharya
Common femoral artery aneurysms are rare, and surgical repair is indicated if they are significantly large, or if they are symptomatic (thrombosis causing limb ischaemia and compression of surrounding structures). Synthetic grafts are preferred, especially in cases involving large aneurysms, or the bifurcation of the common femoral artery. We present a case of bilateral common femoral artery aneurysms extending into the bifurcation repaired using a synthetic graft which is traditionally used for an axillobifemoral bypass...
June 15, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29907444/diagnostic-accuracy-of-asla-score-a-novel-ct-angiographic-index-and-aggregate-plaque-volume-in-the-assessment-of-functional-significance-of-coronary-stenosis
#18
Ravi Kiran Munnur, James D Cameron, Liam M McCormick, Peter J Psaltis, Nitesh Nerlekar, Brian S H Ko, Ian T Meredith, Sujith Seneviratne, Dennis T L Wong
BACKGROUND: Visual assessment of diameter-stenosis on Computed Tomography Coronary Angiography (CTCA) lacks specificity to determine functional significance of coronary artery stenosis. Percent-aggregate plaque volume (%APV) and ASLA score, which incorporates Area of Stenosis, Lesion length, and area of myocardium subtended estimated by APPROACH score (Alberta Provincial Project for Outcome Assessment in Coronary Heart Disease) have been described to predict lesion specific ischaemia in focal lesions with intermediate stenosis...
June 8, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29903719/electroacupuncture-a-new-approach-to-open-the-blood-brain-barrier-in-rats-recovering-from-middle-cerebral-artery-occlusion
#19
Jiangsong Zhang, Xianming Lin, Hui Zhou, Yuanyuan Chen, Shuangkai Xiao, Junyue Jiao, Yibin Zhao, Zhong Di
OBJECTIVE: To examine for an opening effect on the blood-brain barrier (BBB) in intact rats and rats with experimental ischaemia-reperfusion (I/R) during the recovery period after various electroacupuncture (EA) treatments with different time courses, and to determine whether there is a time-dependent effect. An additional objective was to determine whether this method could induce the penetration of nerve growth factor (NGF) through the BBB. METHODS: A middle cerebral artery occlusion (MCAO) model was first established...
June 14, 2018: Acupuncture in Medicine: Journal of the British Medical Acupuncture Society
https://www.readbyqxmd.com/read/29903393/one-year-prognosis-of-non-traumatic-cortical-subarachnoid-haemorrhage-a-prospective-series-of-34-patients
#20
R F Galiano Blancart, G Fortea, A Pampliega Pérez, S Martí, V Parkhutik, A V Sánchez Cruz, C Soriano, D Geffner Sclarsky, M T Pérez Saldaña, N López Hernández, I Beltrán, A Lago Martín
INTRODUCTION: Cortical subarachnoid haemorrhage (cSAH) has multiple aetiologies. No prospective study has reported the long-term progression of the condition. The objective of this study is to describe the clinical and aetiological characteristics of patients with cSAH and to gain insight into prognosis. METHODS: We performed a prospective, observational, multi-centre study. Data on clinical and radiological variables were collected; during a one-year follow-up period, we recorded data on mortality, dependence, rebleeding, and the appearance of dementia...
June 11, 2018: Neurología: Publicación Oficial de la Sociedad Española de Neurología
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