Lei Pei, Ranran Li, Xiaofeng Wang, Dan Xu, Fangchen Gong, Weiwei Chen, Xiangtao Zheng, Wenbin Liu, Shanzhi Zhao, Qiuyun Wang, Enqiang Mao, Erzhen Chen, Ying Chen, Zhitao Yang
Sepsis-associated liver dysfunction (SALD) aggravates the disease progression and prognosis of patients. Macrophages in the liver play a crucial role in the occurrence and development of SALD. Human umbilical cord mesenchymal stem cells (MSCs), by secreting extracellular vesicles (EVs), show beneficial effects in various inflammatory diseases. However, whether MSC-derived EVs (MSC-EVs) could ameliorate the inflammatory response in liver macrophages and the underlying mechanisms remain unclear. In this study, a mouse model of sepsis induced by lipopolysaccharide (LPS) challenge was used to investigate the immunomodulatory functions of MSC-EVs in SALD...
January 26, 2024: International Immunopharmacology