keyword
https://read.qxmd.com/read/38298716/hif-1a-as-a-prognostic-biomarker-related-to-invasion-migration-and-immunosuppression-of-cervical-cancer
#21
JOURNAL ARTICLE
Zhenyu Li, Ran Wei, Shunyu Yao, Fang Meng, Lingsuo Kong
BACKGROUND: The incidence of cervical cancer ranks second among malignant tumors in women, exerting a significant impact on their quality of life and overall well-being. The hypoxic microenvironment plays a pivotal role in the initiation and progression of tumorigenesis. The present study aims to investigate the fundamental genes and pathways associated with the hypoxia-inducible factor (HIF-1A) in cervical cancer, aiming to identify potential downstream targets for diagnostic and therapeutic purposes...
January 30, 2024: Heliyon
https://read.qxmd.com/read/38289159/liensinine-inhibits-progression-of-intrahepatic-cholangiocarcinoma-by-regulating-tgf-%C3%AE-1-p-smad3-signaling-through-hif-1a
#22
JOURNAL ARTICLE
Xuewen Zhu, Wenming Bao, Xiaozai Xie, Bo Chen, Rizhao Li, Jungang Zhao, Lijun Wu, Zhengping Yu, Shi Li, Qiandong Zhu, Gang Chen, Jiacheng Li
Intrahepatic cholangiocarcinoma (ICC) is a high-grade malignant digestive system tumor with an insidious onset and unfavorable prognosis. Liensinine, a small molecule derived from plants, has been proven to have significant tumor suppressor activity in other cancers. However, there are no reports on whether liensinine can inhibit the proliferation or metastasis of ICC. This study aimed to explore the tumor-suppressive activity of liensinine in ICC and its underlying mechanisms. The phenotypic changes in ICC cells were monitored in vitro using cell function tests...
January 30, 2024: Molecular Carcinogenesis
https://read.qxmd.com/read/38280334/mscs-derived-extracellular-vesicles-alleviate-sepsis-associated-liver-dysfunction-by-inhibiting-macrophage-glycolysis-mediated-inflammatory-response
#23
JOURNAL ARTICLE
Lei Pei, Ranran Li, Xiaofeng Wang, Dan Xu, Fangchen Gong, Weiwei Chen, Xiangtao Zheng, Wenbin Liu, Shanzhi Zhao, Qiuyun Wang, Enqiang Mao, Erzhen Chen, Ying Chen, Zhitao Yang
Sepsis-associated liver dysfunction (SALD) aggravates the disease progression and prognosis of patients. Macrophages in the liver play a crucial role in the occurrence and development of SALD. Human umbilical cord mesenchymal stem cells (MSCs), by secreting extracellular vesicles (EVs), show beneficial effects in various inflammatory diseases. However, whether MSC-derived EVs (MSC-EVs) could ameliorate the inflammatory response in liver macrophages and the underlying mechanisms remain unclear. In this study, a mouse model of sepsis induced by lipopolysaccharide (LPS) challenge was used to investigate the immunomodulatory functions of MSC-EVs in SALD...
January 26, 2024: International Immunopharmacology
https://read.qxmd.com/read/38255159/exploring-the-three-dimensional-frontier-advancements-in-msc-spheroids-and-their-implications-for-breast-cancer-and-personalized-regenerative-therapies
#24
REVIEW
Veronika Smolinska, Stefan Harsanyi, Martin Bohac, Lubos Danisovic
To more accurately replicate the in vivo three-dimensional (3D) mesenchymal stem cell (MSC) niche and enhance cellular phenotypes for superior in vivo treatments, MSC functionalization through in vitro 3D culture approaches has gained attention. The organization of MSCs in 3D spheroids results in altered cell shape, cytoskeleton rearrangement, and polarization. Investigations have revealed that the survival and secretory capability of MSCs are positively impacted by moderate hypoxia within the inner zones of MSC spheroids...
December 25, 2023: Biomedicines
https://read.qxmd.com/read/38252891/induced-pluripotent-stem-cell-derived-exosomes-attenuate-vascular-remodelling-in-pulmonary-arterial-hypertension-by-targeting-hif-1%C3%AE-and-runx2
#25
JOURNAL ARTICLE
Pei-Ling Chi, Chin-Chang Cheng, Mei-Tzu Wang, Jia-Bin Liao, Shu-Hung Kuo, Kun-Chang Lin, Min-Ci Shen, Wei-Chun Huang
AIMS: Pulmonary arterial hypertension (PAH) is characterized by extensive pulmonary arterial remodelling. Although mesenchymal stem cell (MSC)-derived exosomes provide protective effects in PAH, MSCs exhibit limited senescence during in vitro expansion compared with the induced pluripotent stem cells (iPSCs). Moreover, the exact mechanism is not known. METHODS AND RESULTS: In this study, we used murine iPSCs generated from mouse embryonic fibroblasts with triple factor (Oct4, Klf4, and Sox2) transduction to determine the efficacy and action mechanism of iPSC-derived exosomes (iPSC-Exo) in attenuating PAH in rats with monocrotaline (MCT)-induced pulmonary hypertension...
January 22, 2024: Cardiovascular Research
https://read.qxmd.com/read/38247203/a-pro-regenerative-supramolecular-prodrug-protects-against-and-repairs-colon-damage-in-experimental-colitis
#26
JOURNAL ARTICLE
Kelsey G DeFrates, Elaine Tong, Jing Cheng, Ellen Heber-Katz, Phillip B Messersmith
Structural repair of the intestinal epithelium is strongly correlated with disease remission in inflammatory bowel disease (IBD); however, ulcer healing is not addressed by existing therapies. To address this need, this study reports the use of a small molecule prolyl hydroxylase (PHD) inhibitor (DPCA) to upregulate hypoxia-inducible factor one-alpha (HIF-1α) and induce mammalian regeneration. Sustained delivery of DPCA is achieved through subcutaneous injections of a supramolecular hydrogel, formed through the self-assembly of PEG-DPCA conjugates...
January 21, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38237887/a-novel-antagonist-of-the-ccl5-ccr5-axis-suppresses-the-tumor-growth-and-metastasis-of-triple-negative-breast-cancer-by-ccr5-yap1-regulation
#27
JOURNAL ARTICLE
Ling Chen, Guiying Xu, Xiaoxu Song, Lianbo Zhang, Chuyu Chen, Gang Xiang, Shuxuan Wang, Zijian Zhang, Fang Wu, Xuanming Yang, Lei Zhang, Xiaojing Ma, Jing Yu
Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer (BC) with a high mortality rate, and few effective therapeutic strategies are available. CCL5/CCR5 is an appealing immunotherapeutic target for TNBC. However, its signaling mechanism is poorly understood and its direct antagonists have not been reported. Here, we developed a high-throughput screening (HTS) assay for discovering its antagonists. Verteporfin was identified as a more selective and potent antagonist than the known CCR5 antagonist maraviroc...
January 16, 2024: Cancer Letters
https://read.qxmd.com/read/38235568/expression-of-the-hif-1%C3%AE-vegf-pathway-is-upregulated-to-protect-alveolar-bone-density-reduction-in-nasal-obstructed-rats
#28
JOURNAL ARTICLE
Zishan Liu, Yongming Li
BACKGROUND: Hypoxia and mouth breathing are closely related to maxillofacial bone metabolism and are characteristic of obstructive sleep apnea-hypopnea syndrome (OSAHS). Being key factors in the hypoxia response, hypoxia-inducible factor 1α (HIF-1α) and HIF-responsive gene vascular endothelial growth factor (VEGF) are essential for bone remodeling. This study focuses on the role of the HIF-1α/VEGF pathway in alveolar bone metabolism during OSAHS. MATERIALS AND METHODS: 36 three-week-old male Wistar rats were divided into three groups: twelve control rats, twelve bilateral nasal obstructed (BNO) rats, twelve BNO rats treated with intraperitoneal injection of Dimethyloxalylglycine (DMOG)...
January 2, 2024: Histology and Histopathology
https://read.qxmd.com/read/38232132/series-of-desloratadine-platinum-iv-hybrids-displaying-potent-antimetastatic-competence-by-inhibiting-epithelial-mesenchymal-transition-and-arousing-immune-response
#29
JOURNAL ARTICLE
Ming Zhang, Yan Chen, Zhifang Liu, Min Liu, Qingpeng Wang
Metastasis is the major obstacle to the survival of cancer patients. Herein, a series of new desloratadine platinum(IV) conjugates with promising antiproliferative and antimetastatic activities were developed and evaluated. The candidate complex caused significant DNA damage and stimulated mitochondrial apoptosis through the Bcl-2/Bax/caspase3 pathway. Then, it suppressed the epithelial-mesenchymal transition (EMT) process in tumors effectively through NMT-1/HPCAL1 and β-catenin signaling. Subsequently, the angiogenesis was inhibited with the downregulation of key proteins HIF-1α, VEGFA, MMP-9, and CD34...
January 17, 2024: Journal of Medicinal Chemistry
https://read.qxmd.com/read/38228132/downregulation-of-tet2-contributes-to-nasal-polypogenesis-through-hif1%C3%AE-mediated-epithelial-to-mesenchymal-transition
#30
JOURNAL ARTICLE
Kunyu Liu, Yu Xu
OBJECTIVES: Hypoxia-inducible factor (HIF) 1α and Ten-eleven translocation 2 (TET2) have been reported to mediate nasal polypogenesis through epithelial-to-mesenchymal transition (EMT). Besides, expression and function of TET2 can be regulated by HIF1α. However, the precise mechanism of how TET2 regulated EMT through HIF1α-induced EMT in nasal epithelial cell is still poorly understood. METHODS: Nasal tissue samples were collected from patients with CRSwNP, CRSsNP and controls...
December 28, 2023: Clinical and Experimental Otorhinolaryngology
https://read.qxmd.com/read/38226010/cobalt-doped-layered-hydroxide-coating-on-titanium-implants-promotes-vascularization-and-osteogenesis-for-accelerated-fracture-healing
#31
JOURNAL ARTICLE
Xiaodong Chen, Shuohan He, Yilong Dong, Maohua Chen, Zengzilu Xia, Kaiyong Cai, Yan Hu
Angiogenesis at the fracture site plays crucial roles in the endogenous osteogenesis process and is a prerequisite for the efficient repair of implant fixed bone defects. To improve the peri-implant vascularization of titanium implant for accelerating defect healing, we developed a Co-doped Mg-Al layered hydroxide coating on the surface of titanium using hydrothermal reaction and then modified the surface with gallic acid (Ti-LDH/GA). Gallic acid coating enabled the sustained release of Co2+ and Mg2+ to the defect site over a month...
February 2024: Materials today. Bio
https://read.qxmd.com/read/38213726/ldh-a-inhibitor-as-a-remedy-to-potentiate-the-anticancer-effect-of-docetaxel-in-prostate-cancer
#32
JOURNAL ARTICLE
Cagri Cakici, Benay Daylan, Ruveyde Safiye Unluer, Ebru Emekli-Alturfan, Sule Ayla, Hilal Eren Gozel, Pakize Yigit, Elif Yavuz Dokgoz, Turkan Yigitbasi
Increased LDH-A activity promotes tumor growth, migration, invasion, and metastasis. This study aimed to investigate the effects of the combination of LDH-A inhibitor and Docetaxel on apoptosis and epithelial-mesenchymal transition (EMT) in the murine prostate cancer (PCa) model. The prostate cancer murine model was developed subcutaneously in 50 male B57CL/6 mice using the Tramp-C2 prostate cancer cell line. From the tumor tissue samples, apoptosis analysis was performed using TUNEL staining, and EMT was investigated using western blot and qPCR...
2024: Journal of Cancer
https://read.qxmd.com/read/38211551/challenging-the-anticolorectal-cancer-capacity-of-quinoxaline-based-scaffold-via-triazole-ligation-unveiled-new-efficient-dual-vegfr-2-mao-b-inhibitors
#33
JOURNAL ARTICLE
Mohammed Salah Ayoup, Ahmed Ammar, Hamida Abdel-Hamid, Adel Amer, Marwa M Abu-Serie, Samah A Nasr, Doaa A Ghareeb, Mohamed Teleb, Gina N Tageldin
Monoamine oxidases (MAOs) and vascular endothelial growth factor receptor-2 (VEGFR-2) are promoters of colorectal cancer (CRC) and central signaling nodes in epithelial-mesenchymal transition (EMT) induced by activating hypoxia-inducible factors (HIFs). Herein, a novel series of rationally designed triazole-tethered quinoxalines were synthesized and evaluated against HCT-116 CRC cells. The tailored scaffolds combine the pharmacophoric themes of both VEGFR-2 inhibitors and MAO inhibitors. All the synthesized derivatives were screened utilizing the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay for their possible cytotoxic effects on normal human colonocytes, then evaluated for their anticancer activities against HCT-116 cells overexpressing MAOs...
January 6, 2024: Bioorganic Chemistry
https://read.qxmd.com/read/38195914/hsa_circ_0081065-exacerbates-ih-induced-endmt-via-regulating-mir-665-hif-1%C3%AE-signal-axis-and-hif-1%C3%AE-nuclear-translocation
#34
JOURNAL ARTICLE
Shan Jiang, Xiaowei Xing, Ming Hong, Xingqian Zhang, Fei Xu, Guang-Hao Zhang
CircRNAs play an important role in various physiological and pathological biological processes. Despite their widespread involvement, the function of circRNAs in intermittent hypoxia (IH) remain incompletely understood. This study aims to clarify the molecular mechanism of it in IH. Differentially expressed circRNAs were identified by transcriptome sequencing analysis in intermittent hypoxia (IH) model. GO and KEGG enrichment analys were performed on the identified differentially expressed circRNAs. The circular characteristics of hsa_circ_0081065 in human umbilical vein endothelial cells (HUVECs) were detected by RT-qPCR...
January 9, 2024: Scientific Reports
https://read.qxmd.com/read/38182070/unraveling-the-molecular-mechanisms-of-cell-migration-impairment-and-apoptosis-associated-with-steroid-sulfatase-deficiency-implications-for-x-linked-ichthyosis
#35
JOURNAL ARTICLE
Tae-Uk Kwon, Yeo-Jung Kwon, Hyoung-Seok Baek, Hyemin Park, Hyein Lee, Young-Jin Chun
Steroid sulfatase (STS) deficiency is responsible for X-linked ichthyosis (XLI), a genetic disorder characterized by rough and dry skin caused by excessive keratinization. The impaired keratinization process leads to reduced cell mobility and increased apoptosis, which can cause an excessive buildup of the stratum corneum. In this study, we investigated the mechanisms underlying XLI and found that STS deficiency reduces cell mobility and increases apoptosis in human keratinocyte HaCaT cells. To explore these mechanisms further, RNA-sequencing was conducted on skin tissues from STS transgenic and knockout mice...
January 3, 2024: Biochimica et Biophysica Acta. Molecular Basis of Disease
https://read.qxmd.com/read/38175202/cd204-positive-m2-like-tumor-associated-macrophages-increase-migration-of-gastric-cancer-cells-by-upregulating-mir-210-to-reduce-ntn4-expression
#36
JOURNAL ARTICLE
Chin-Wang Chen, Hao-Chen Wang, I-Min Tsai, I-Shu Chen, Chang-Jung Chen, Ya-Chin Hou, Yan-Shen Shan
BACKGROUND: Tumor-associated macrophages (TAMs) are the predominant immune cells in the tumor microenvironment and portend poor prognosis. However, the molecular mechanisms underlying the tumor promotion of TAMs have not been fully elucidated. METHODS: Coculture of gastric cancer cells with U937 cells was performed to investigate the impact of TAMs on cancer cell behavior. MicroRNA (miRNA) microarray and bioinformatics were applied to identify the involved miRNAs and the functional target genes...
January 4, 2024: Cancer Immunology, Immunotherapy: CII
https://read.qxmd.com/read/38165484/associations-between-hifs-and-tumor-immune-checkpoints-mechanism-and-therapy
#37
REVIEW
Jiayu Liu, Ying Jiang, Lingyan Chen, Zhiwen Qian, Yan Zhang
Hypoxia, which activates a variety of signaling pathways to enhance tumor cell growth and metabolism, is among the primary features of tumor cells. Hypoxia-inducible factors (HIFs) have a substantial impact on a variety of facets of tumor biology, such as epithelial-mesenchymal transition, metabolic reprogramming, angiogenesis, and improved radiation resistance. HIFs induce hypoxia-adaptive responses in tumor cells. Many academics have presented preclinical and clinical research targeting HIFs in tumor therapy, highlighting the potential applicability of targeted HIFs...
January 2, 2024: Discover. Oncology
https://read.qxmd.com/read/38157907/the-role-of-%C3%AE-7-nachr-mediated-pi3k-akt-pathway-in-lung-cancer-induced-by-nicotine
#38
REVIEW
Zihan He, Yuqin Xu, Zihan Rao, Zhongwei Zhang, Jianming Zhou, Tong Zhou, Huai Wang
Nicotine enters the environment mainly through human activity, as well as natural sources. This review article examines the increasing evidence implicating nicotine in the initiation and progression of lung cancer. Moreover, it primarily focuses on elucidating the activation mechanism of phosphoinositide 3-kinase (PI3K)/protein kinase B (PKB, also known as AKT) signaling pathway, regulated by α7 subtype nicotinic acetylcholine receptor (α7-nAChR), in relation to the proliferation, invasion, and metastasis of lung cancer cells induced by nicotine, as well as nicotine-mediated anti-apoptotic effects...
December 27, 2023: Science of the Total Environment
https://read.qxmd.com/read/38154967/acy-241-a-histone-deacetylase-6-inhibitor-suppresses-the-epithelial-mesenchymal-transition-in-lung-cancer-cells-by-downregulating-hypoxia-inducible-factor-1-alpha
#39
JOURNAL ARTICLE
Seong-Jun Park, Naeun Lee, Chul-Ho Jeong
Hypoxia-inducible factor-1 alpha (HIF-1α) is a transcription factor activated under hypoxic conditions, and it plays a crucial role in cellular stress regulation. While HIF-1α activity is essential in normal tissues, its presence in the tumor microenvironment represents a significant risk factor as it can induce angiogenesis and confer resistance to anti-cancer drugs, thereby contributing to poor prognoses. Typically, HIF-1α undergoes rapid degradation in normoxic conditions via oxygen-dependent degradation mechanisms...
January 1, 2024: Korean Journal of Physiology & Pharmacology
https://read.qxmd.com/read/38145606/investigating-the-therapeutic-effects-and-mechanisms-of-roxadustat-on-peritoneal-fibrosis-based-on-the-tgf-%C3%AE-smad-pathway
#40
JOURNAL ARTICLE
Lingyun Wang, Jiangqing Fan, Ting Yang, Jizhong Shen, Lulu Wang, Weihong Ge
Peritoneal fibrosis (PF) is particularly common in individuals undergoing peritoneal dialysis (PD). Fibrosis of the parenchymal tissue typically progresses slowly. Therefore, preventing and reducing the advancement of fibrosis is crucial for effective patient treatment. Roxadustat is a hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI), primarily used to treat and improve renal anemia. Recent studies have found that HIF-1α possesses antioxidant activity and exerts a certain protective effect in ischemic heart disease and spinal cord injury, while it can also delay the progression of pulmonary and renal fibrosis...
December 14, 2023: Biochemical and Biophysical Research Communications
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