keyword
MENU ▼
Read by QxMD icon Read
search

Information Systems

keyword
https://www.readbyqxmd.com/read/29161596/an-in-toto-approach-to-dissecting-cellular-interactions-in-complex-tissues
#1
Pavak Kirit Shah, Anthony Santella, Adrian Jacobo, Kimberly Siletti, A J Hudspeth, Zhirong Bao
Single-cell measurements have broadened our understanding of heterogeneity in biology, yet have been limited to mostly observational studies of normal or globally perturbed systems. Typically, perturbations are utilized in an open-ended approach wherein an endpoint is assayed during or after the biological event of interest. Here we describe ShootingStar, a platform for perturbation analysis in vivo, which combines live imaging, real-time image analysis, and automated optical perturbations. ShootingStar builds a quantitative record of the state of the sample being analyzed, which is used to automate the identification of target cells for perturbation, as well as to validate the impacts of the perturbation...
November 20, 2017: Developmental Cell
https://www.readbyqxmd.com/read/29161593/mitotic-cortical-waves-predict-future-division-sites-by-encoding-positional-and-size-information
#2
Shengping Xiao, Cheesan Tong, Yang Yang, Min Wu
Dynamic spatial patterns such as traveling waves could theoretically encode spatial information, but little is known about whether or how they are employed by biological systems, especially higher eukaryotes. Here, we show that concentric target or spiral waves of active Cdc42 and the F-BAR protein FBP17 are invoked in adherent cells at the onset of mitosis. These waves predict the future sites of cell divisions and represent the earliest known spatial cues for furrow assembly. Unlike interphase waves, the frequencies and wavelengths of the mitotic waves display size-dependent scaling properties...
November 20, 2017: Developmental Cell
https://www.readbyqxmd.com/read/29161505/characterization-of-the-distribution-of-pyrene-molecules-in-confined-geometries-with-the-model-free-analysis
#3
Xinzhi Cao, Remi Casier, Hunter Little, Jean Duhamel
Evidence is provided showing that global Model Free Analysis (MFA) of monomer and excimer fluorescence decays of pyrene dissolved in aqueous solutions of sodium dodecyl sulfate (SDS) provides the same structural and dynamic information on SDS micelles as the well-established Micelle Model (MM) does. Both MFA and MM were employed to characterize the quenching kinetics between dyes and quenchers located in surfactant micelles and the aggregation number of surfactant micelles. However, contrary to the MM which assumes that dyes and quenchers distribute themselves among SDS micelles according to a Poisson distribution and react with a rate constant that is proportional to the number of reactants in a micelle, the MFA accomplishes this task without making any assumption about the process of pyrene excimer formation in SDS micelles...
November 21, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29161465/neuromuscular-electrical-stimulation-for-the-prevention-of-venous-thromboembolism
#4
REVIEW
Shahab Hajibandeh, Shahin Hajibandeh, George A Antoniou, James Rh Scurr, Francesco Torella
BACKGROUND: Venous thromboembolism (VTE) is a serious but preventable cause of morbidity and mortality. Neuromuscular electrical stimulation systems (NMES) for the prevention of VTE may be beneficial for patients in whom pharmacological or standard mechanical prophylaxis methods are contraindicated or are regarded as unsafe or impractical. Although findings of experimental studies suggest that NMES reduce venous stasis, the clinical utility and effectiveness of NMES in VTE prevention remain controversial...
November 21, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29161304/proposal-for-a-common-nomenclature-for-fragment-ions-in-mass-spectra-of-lipids
#5
Josch K Pauling, Martin Hermansson, Jürgen Hartler, Klaus Christiansen, Sandra F Gallego, Bing Peng, Robert Ahrends, Christer S Ejsing
Advances in mass spectrometry-based lipidomics have in recent years prompted efforts to standardize the annotation of the vast number of lipid molecules that can be detected in biological systems. These efforts have focused on cataloguing, naming and drawing chemical structures of intact lipid molecules, but have provided no guidelines for annotation of lipid fragment ions detected using tandem and multi-stage mass spectrometry, albeit these fragment ions are mandatory for structural elucidation and high confidence lipid identification, especially in high throughput lipidomics workflows...
2017: PloS One
https://www.readbyqxmd.com/read/29161280/microbial-caddisfly-bioherm-association-from-the-lower-cretaceous-shinekhudag-formation-mongolia-earliest-record-of-plant-armoring-in-fossil-caddisfly-cases
#6
Tsolmon Adiya, Cari L Johnson, Mark A Loewen, Kathleen A Ritterbush, Kurt N Constenius, Cory M Dinter
Caddisfly larvae construct underwater protective cases using surrounding materials, thus providing information on environmental conditions in both modern and ancient systems. Microbial bioherms associated with caddisfly cases are found in the Berriassian-Hauterivian (~140-130 Ma) Shinekhudag Formation of Mongolia, and yield new insights into aspects of lacustrine paleoecosystems and paleoenvironments. This formation contains the earliest record of plant-armored caddisfly cases and a rare occurrence of microbial-caddisfly association from the Mesozoic...
2017: PloS One
https://www.readbyqxmd.com/read/29160772/crystal-identification-for-a-dual-layer-offset-lyso-based-pet-system-via-lu-176-background-radiation-and-mean-shift-algorithm
#7
Qingyang Wei, Tianyu Ma, Tianpeng Xu, Ming Zeng, Yu Gu, Tiantian Dai, Yaqiang Liu
Modern positron emission tomography (PET) detectors are made from pixelated scintillation crystal arrays and readout by Anger logic. The interaction position of the gamma-ray should be assigned to a crystal using a crystal position map or look-up table. Crystal identification is a critical procedure for pixelated PET systems. In this paper, we propose a novel crystal identification method for a dual-layer-offset LYSO based animal PET system via Lu-176 background radiation and mean shift algorithm. Single photon event data of the Lu-176 background radiation are acquired in list-mode for 3 hours to generate a single photon flood map (SPFM)...
November 21, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29160637/fetal-surgery-for-lower-urinary-tract-obstruction-the-importance-of-staging-prior-to-intervention
#8
Elizabeth A Enninga, Rodrigo Ruano
Fetal lower urinary tract obstruction (LUTO) is a heterogeneous pathology associated with a high morbidity and mortality due to pulmonary hypoplasia. Previously, when a fetus was diagnosed on ultrasound with LUTO, expectant care or termination was the only option; this has changed because of fetal surgical intervention. Vesicoamniotic shunts and cystoscopy are the current methods utilized to treat LUTO; however, it remains difficult to determine whether or not fetal prognosis favors intervention and long term outcome follow up has been limited...
November 21, 2017: Minerva Pediatrica
https://www.readbyqxmd.com/read/29160594/leptin-action-in-normal-and-pathological-pregnancies
#9
REVIEW
Antonio Pérez-Pérez, Ayelén Toro, Teresa Vilariño-García, Julieta Maymó, Pilar Guadix, José L Dueñas, Manuel Fernández-Sánchez, Cecilia Varone, Víctor Sánchez-Margalet
Leptin is now considered an important signalling molecule of the reproductive system, as it regulates the production of gonadotrophins, the blastocyst formation and implantation, the normal placentation, as well as the foeto-placental communication. Leptin is a peptide hormone secreted mainly by adipose tissue, and the placenta is the second leptin-producing tissue in humans. Placental leptin is an important cytokine which regulates placental functions in an autocrine or paracrine manner. Leptin seems to play a crucial role during the first stages of pregnancy as it modulates critical processes such as proliferation, protein synthesis, invasion and apoptosis in placental cells...
November 21, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29160462/access-to-medicines-relations-with-the-institutionalization-of-pharmaceutical-services
#10
Rafael Damasceno de Barros, Ediná Alves Costa, Djanilson Barbosa Dos Santos, Gisélia Santana Souza, Juliana Álvares, Augusto Afonso Guerra, Francisco de Assis Acurcio, Ione Aquemi Guibu, Karen Sarmento Costa, Margô Gomes de Oliveira Karnikowski, Orlando Mario Soeiro, Silvana Nair Leite
OBJETIVE: To analyze the relationship between access to medicines by the population and the institutionalization of pharmaceutical services in Brazilian primary health care. METHODS: This study is part of the Pesquisa Nacional sobre Acesso, Utilização e Promoção do Uso Racional de Medicamentos - Serviços 2015 (PNAUM - National Survey on Access, Use and Promotion of Rational Use of Medicines - Services 2015), a cross-sectional, exploratory, and evaluative study composed of an information survey in a representative sample of cities, stratified by Brazilian regions...
November 13, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29160459/characterization-of-the-institutionalization-of-pharmaceutical-services-in-brazilian-primary-health-care
#11
Gisélia Santana Souza, Ediná Alves Costa, Rafael Damasceno de Barros, Marcelo Tavares Pereira, Joslene Lacerda Barreto, Augusto Afonso Guerra, Francisco de Assis Acurcio, Ione Aquemi Guibu, Juliana Álvares, Karen Sarmento Costa, Margô Gomes de Oliveira Karnikowski, Orlando Mario Soeiro, Silvana Nair Leite
OBJECTIVE: To characterize the current stage of the institutionalization of pharmaceutical services in Brazilian cities. METHODS: This study is part of the Pesquisa Nacional sobre Acesso, Utilização e Promoção do Uso Racional de Medicamentos (PNAUM - National Survey on Access, Use and Promotion of Rational Use of Medicines), a cross-sectional, exploratory, and evaluative study composed by an information survey in a representative sample of cities, stratified by Brazilian regions...
November 13, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29160457/medicine-dispensing-service-in-primary-health-care-of-sus
#12
Silvana Nair Leite, Noemia Liege Maria da Cunha Bernardo, Juliana Álvares, Augusto Afonso Guerra, Ediná Alves Costa, Francisco de Assis Acurcio, Ione Aquemi Guibu, Karen Sarmento Costa, Margô Gomes de Oliveira Karnikowski, Orlando Mario Soeiro, Luciano Soares
OBJECTIVE: To characterize the medicine dispensing services in the primary health care network in Brazil and in its different regions, aiming to promote the access and rational use of medicines. METHODS: This is a cross-sectional, quantitative study with data obtained from the Pesquisa Nacional sobre Acesso, Utilização e Uso Racional de Medicamentos (PNAUM - National Survey on Access, Use and Promotion of Rational Use of Medicines), 2015. Observation visits were carried out in 1,175 dispensing units, and interviews were held with 1,139 professionals responsible for the dispensation of medicines in the dispensing units and 495 municipal coordinators of pharmaceutical services...
November 13, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29160456/infrastructure-of-pharmacies-of-the-primary-health-care-in-the-brazilian-unified-health-system-analysis-of-pnaum-services-data
#13
Silvana Nair Leite, Fernanda Manzini, Juliana Álvares, Augusto Afonso Guerra, Ediná Alves Costa, Francisco de Assis Acurcio, Ione Aquemi Guibu, Karen Sarmento Costa, Margô Gomes de Oliveira Karnikowski, Orlando Mário Soeiro, Mareni Rocha Farias
OBJECTIVE: To characterize the infrastructure of the primary health care pharmacies of the Brazilian Unified Health System, aiming at humanizing the offered services. METHODS: This is a cross-sectional study, of quantitative approach, from data obtained in the Pesquisa Nacional de Acesso, Utilização e Promoção do Uso Racional de Medicamentos - Serviços, 2015 (PNAUM - National Survey on Access, Use and Promotion of Rational Use of Medicines - Services, 2015)...
November 13, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29160454/pharmaceutical-care-in-brazil-s-primary-health-care
#14
Patricia Sodré Araújo, Ediná Alves Costa, Augusto Afonso Guerra, Francisco de Assis Acurcio, Ione Aquemi Guibu, Juliana Álvares, Karen Sarmento Costa, Margô Gomes de Oliveira Karnikowski, Orlando Mario Soeiro, Silvana Nair Leite
OBJECTIVE: To characterize the activities of clinical nature developed by pharmacists in basic health units and their participation in educational activities aiming at health promotion. METHODS: This article is part of the Pesquisa Nacional sobre Acesso, Utilização e Promoção do Uso Racional de Medicamentos - Serviços, 2015 (PNAUM - National Survey on Access, Use and Promotion of Rational Use of Medicines - Services, 2015), a cross-sectional and exploratory study, of evaluative nature, consisting of a survey of information in a representative sample of cities, stratified by the Brazilian regions that constitute domains of study, and a subsample of primary health care services...
November 13, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29160452/technical-issues-and-conservation-conditions-of-medicines-in-the-primary-health-care-of-the-brazilian-unified-health-system
#15
Ediná Alves Costa, Patrícia Sodré Araújo, Marcelo Tavares Pereira, Ana Cristina Souto, Gisélia Santana Souza, Augusto Afonso Guerra, Francisco de Assis Acurcio, Ione Aquemi Guibu, Juliana Alvares, Karen Sarmento Costa, Margô Gomes de Oliveira Karnikowski, Orlando Mario Soeiro, Silvana Nair Leite
OBJECTIVE: To characterize the technical issues and conditions of medicines conservation in Primary Health Care of Brazilian regions, responsible for pharmacy/dispensing unit profile; environmental, storage, and dose fractioning conditions; inventory control and waste management; fire and electrical failure safety items; transportation problems; advertising regulation; and pharmacovigilance. METHODS: This article is part of the Pesquisa Nacional sobre Acesso, Utilização e Promoção do Uso Racional de Medicamentos - Serviços (National Survey on Access, Use and Promotion of Rational Use of Medicines - Services)-, a cross-sectional and exploratory study, of evaluative nature, consisting of an information survey within a representative sample of municipalities, stratified by Brazilian regions, which constitute the study domains, and a sample of Primary Health Care services...
November 13, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29160447/financing-of-pharmaceutical-services-in-the-municipal-management-of-the-brazilian-unified-health-system
#16
Daniel Resende Faleiros, Francisco de Assis Acurcio, Juliana Álvares, Renata Cristina Rezende Macedo do Nascimento, Ediná Alves Costa, Ione Aquemi Guibu, Orlando Mario Soeiro, Silvana Nair Leite, Margô Gomes de Oliveira Karnikowski, Karen Sarmento Costa, Augusto Afonso Guerra
OBJECTIVE: To discuss factors related to the financing of the Basic Component of Pharmaceutical Services within the municipal management of the Brazilian Unified Health System. METHODS: The Pesquisa Nacional sobre Acesso, Utilização e Promoção do Uso Racional de Medicamentos no Brasil - Serviços (PNAUM - National Survey on Access, Use and Promotion of Rational Use of Medicines - Services) is a cross-sectional, exploratory, and evaluative study that performed an information survey in a representative sample, stratified by Brazilian regions It considered different study populations in the sampling plan, which represent primary health care services in the cities...
November 13, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29160445/epidemiological-profile-of-tuberculosis-in-s%C3%A3-o-paulo-municipality-from-2006-to-2013
#17
Priscila Fernanda Porto Scaff Pinto, Cássio Silveira, Maria Josefa Penon Rujula, Francisco Chiaravalloti, Manoel Carlos Sampaio de Almeida Ribeiro
BACKGROUND: Tuberculosis is a serious public health problem that still persists in the world and in Brazil. The municipality of São Paulo, Brazil, is among the prioritized ones in the country for disease control. OBJECTIVE: To describe the epidemiological profile of all new tuberculosis cases in São Paulo municipality reported between the years 2006 and 2013. METHODS: The variables selected for the study were: socioeconomic, demographic and clinical-epidemiologic obtained through the online information system TB-WEB...
July 2017: Revista Brasileira de Epidemiologia, Brazilian Journal of Epidemiology
https://www.readbyqxmd.com/read/29160415/interregional-correlations-of-glucose-metabolism-between-the-basal-ganglia-and-different-cortical-areas-an-ultra-high-resolution-pet-mri-fusion-study-using-18f-fdg
#18
J H Kim, Y D Son, J M Kim, H K Kim, Y B Kim, C Lee, C H Oh
Basal ganglia have complex functional connections with the cerebral cortex and are involved in motor control, executive functions of the forebrain, such as the planning of movement, and cognitive behaviors based on their connections. The aim of this study was to provide detailed functional correlation patterns between the basal ganglia and cerebral cortex by conducting an interregional correlation analysis of the 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) data based on precise structural information...
November 13, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/29160039/fine-tuning-the-p-pastoris-imt1026-genome-scale-metabolic-model-for-improved-prediction-of-growth-on-methanol-or-glycerol-as-sole-carbon-sources
#19
Màrius Tomàs-Gamisans, Pau Ferrer, Joan Albiol
The methylotrophic yeast Pichia pastoris (Komagataella spp.) is widely used as cell factory for recombinant protein production. In the past recent years, important breakthroughs in the systems-level quantitative analysis of its physiology have been achieved. This wealth of information has allowed the development of genome-scale metabolic models, which make new approaches possible for host cell and bioprocess engineering. Nevertheless, the predictive accuracy of the previous consensus model required to be upgraded and validated with new experimental data sets for P...
November 21, 2017: Microbial Biotechnology
https://www.readbyqxmd.com/read/29159885/two-stage-ionoacoustic-range-verification-leveraging-monte-carlo-and-acoustic-simulations-to-stably-account-for-tissue-inhomogeneity-and-accelerator-specific-time-structure-a-simulation-study
#20
Sarah K Patch, Daniel E M Hoff, Tyler B Webb, Lee G Sobotka, Tianyu Zhao
PURPOSE: Range errors constrain treatment planning by limiting choice of ion beam angles and requiring large margins. Ionoacoustic range verification requires recovering the location of an acoustic source from low frequency signals. A priori information is applied to stably overcome resolution limits of inverse acoustic source imaging in this simulation study. In particular, the accuracy and robustness of ionoacoustic range verification for lateral and oblique delivery of high-energy protons to the prostate is examined...
November 20, 2017: Medical Physics
keyword
keyword
12505
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"