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https://www.readbyqxmd.com/read/28743172/modelling-nutritional-mutualisms-challenges-and-opportunities-for-data-integration
#1
REVIEW
Teresa J Clark, Colleen A Friel, Emily Grman, Yair Shachar-Hill, Maren L Friesen
Nutritional mutualisms are ancient, widespread, and profoundly influential in biological communities and ecosystems. Although much is known about these interactions, comprehensive answers to fundamental questions, such as how resource availability and structured interactions influence mutualism persistence, are still lacking. Mathematical modelling of nutritional mutualisms has great potential to facilitate the search for comprehensive answers to these and other fundamental questions by connecting the physiological and genomic underpinnings of mutualisms with ecological and evolutionary processes...
July 25, 2017: Ecology Letters
https://www.readbyqxmd.com/read/28742931/dynamics-of-lipids-and-metabolites-during-the-cell-cycle-of-chlamydomonas-reinhardtii
#2
Jessica Jüppner, Umarah Mubeen, Andrea Leisse, Camila Caldana, Henrike Brust, Martin Steup, Marion Herrmann, Dirk Steinhauser, Patrick Giavalisco
Metabolites and lipids are the final products of enzymatic processes, distinguishing the different cellular functions and activities of single cells or whole tissues. Understanding these cellular functions within a well-established model system, requires a systemic collection of molecular and physiological information. In the current report, the green algae Chlamydomonas reinhardtii was selected to establish a comprehensive workflow for the detailed multi-omics analysis of a synchronously growing cell culture system...
July 25, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/28742853/leadership-and-management-training-as-a-catalyst-to-health-system-strengthening-in-low-income-settings-evidence-from-implementation-of-the-zambia-management-and-leadership-course-for-district-health-managers-in-zambia
#3
Wilbroad Mutale, Anne-Thora Vardoy-Mutale, Arthur Kachemba, Roman Mukendi, Kupela Clarke, Dennis Mulenga
BACKGROUND: Research has shown that the modes of leadership and management may influence health outcomes. However, majority of health leaders and managers in many low-income countries are promoted on account of clinical expertise. It has been recognised that these new managers are often ill-prepared for managing complex health systems. In response to this challenge, the Zambian Ministry of Health (MoH) has developed the Governance and Management Capacity Building (GMCB) Strategic Plan (2012-2016), whose overarching goal is to improve health sector governance and create an environment that is result-oriented, accountable and transparent...
2017: PloS One
https://www.readbyqxmd.com/read/28742851/knowledge-attitude-and-practice-for-cervical-cancer-prevention-and-control-among-women-of-childbearing-age-in-hossana-town-hadiya-zone-southern-ethiopia-community-based-cross-sectional-study
#4
Yitagesu Habtu Aweke, Samuel Yohannes Ayanto, Tariku Laelago Ersado
BACKGROUND: Cervical cancer is the second most common female cancer which Ethiopia put a strategic goal to reduce its incidence and mortality by 2020. Lack of knowledge and poor attitude towards the disease and risk factors can affect screening practice and development of preventive behavior for cervical cancer. The aim of this study was to assess knowledge, attitude, practices and factors for each domain for cervical cancer among women of child bearing age in Hossana town, Southern, Ethiopia...
2017: PloS One
https://www.readbyqxmd.com/read/28742757/concurrent-validity-and-responsiveness-of-promis-health-domains-among-patients-presenting-for-anterior-cervical-spine-surgery
#5
Taylor E Purvis, Elena Andreou, Brian J Neuman, Lee H Riley, Richard L Skolasky
STUDY DESIGN: Prospective cohort study. OBJECTIVE: To determine validity and responsiveness of Patient-Reported Outcomes Measurement Information System (PROMIS) health domains. SUMMARY OF BACKGROUND DATA: PROMIS health domains (anxiety, depression, fatigue, pain, physical function, satisfaction with participation in social roles, sleep disturbance) may measure quality of care and determine minimal important differences (MIDs) after spine surgery...
July 24, 2017: Spine
https://www.readbyqxmd.com/read/28742610/near-point-of-convergence-and-gait-deficits-in-adolescents-after-sport-related-concussion
#6
David R Howell, Michael J OʼBrien, Aparna Raghuram, Ankoor S Shah, William P Meehan
OBJECTIVE: To prospectively examine gait characteristics of participants acutely after concussion with and without receded near point of convergence (NPC), compared with healthy controls. DESIGN: Cross-sectional study. SETTING: Sports-medicine clinic. PARTICIPANTS: Patients examined after concussion (n = 33; mean ± SD = 7.2 ± 3.1 days) and a group of uninjured athletes (n = 31) completed a Postconcussion Symptom Scale, underwent NPC testing, and single/dual-task gait assessments...
July 21, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/28742602/is-there-a-relationship-between-the-functional-movement-screen-star-excursion-balance-test-and-balance-error-scoring-system
#7
Nicole D Harshbarger, Barton E Anderson, Kenneth C Lam
OBJECTIVE: To evaluate associations between the Functional Movement Screen (FMS), Star Excursion Balance Test (SEBT), and Balance Error Scoring System (BESS) scores. DESIGN: Correlational. SETTING: College athletic training facilities. PARTICIPANTS: Fifty-two intercollegiate athletes (men = 36 and women = 16) representing 8 sports and cleared for unrestricted sport participation. INTERVENTIONS: Participants completed the FMS, SEBT, and BESS, in random order, during 1 testing session...
July 21, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/28742544/the-marginal-costs-of-adverse-drug-events-associated-with-exposures-to-anticoagulants-and-hypoglycemic-agents-during-hospitalization
#8
William D Spector, Rhona Limcangco, Michael F Furukawa, William E Encinosa
BACKGROUND: Anticoagulants and hypoglycemic agents are 2 of the most challenging drug classes for medical management in the hospital resulting in many adverse drug events (ADE). OBJECTIVE: Estimating the marginal cost (MC) of ADEs associated with anticoagulants and hypoglycemic agents for adults in 5 patient groups during their hospital stay and the total annual ADE costs for all patients exposed to these drugs during their stay. RESEARCH DESIGN AND SUBJECT: Data are from 2010 to 2013 Healthcare Cost and Utilization Project (HCUP) State Inpatient Databases and Medicare Patient Safety Monitoring System (MPSMS)...
July 24, 2017: Medical Care
https://www.readbyqxmd.com/read/28742524/early-postnatal-echocardiographic-assessment-of-pulmonary-blood-flow-in-newborns-with-congenital-diaphragmatic-hernia
#9
Florian Kipfmueller, Katrin Heindel, Lukas Schroeder, Christoph Berg, Oliver Dewald, Heiko Reutter, Peter Bartmann, Andreas Mueller
OBJECTIVE: Echocardiography is the most important tool to assess infants with congenital diaphragmatic hernia (CDH) for pulmonary hypertension (PH). The pattern of blood flow in the pulmonary artery [described as time to peak velocity (TPV)/right ventricular ejection time (RVET) ratio] provides distinct information about pulmonary arterial pressure. The aim of our study was to investigate the correlation of TPV/RVET measurements with the most commonly used classification system for PH in CDH newborns and the association of these measurements with outcome parameters...
July 25, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28742457/epidemic-network-analysis-for-mitigation-of-invasive-pathogens-in-seed-systems-potato-in-ecuador
#10
Christopher Buddenhagen, John Hernandez Nopsa, Kelsey F Andersen, Jorge Andrade-Piedra, Greg Forbes, Peter Kromann, Sara Thomas-Sharma, Pilar Useche, Karen A Garrett
Seed systems have an important role in the distribution of high quality seed and improved varieties. The structure of seed networks also helps to determine the epidemiological risk for seedborne disease. We present a new method for evaluating the epidemiological role of nodes in seed networks, and apply it to a regional potato farmer consortium (CONPAPA) in Ecuador. We surveyed farmers to estimate the structure of networks of farmer seed tuber and ware potato transactions, and farmer information sources about pest and disease management...
July 25, 2017: Phytopathology
https://www.readbyqxmd.com/read/28742410/content-analysis-of-advantages-and-disadvantages-of-drinking-among-individuals-with-the-lived-experience-of-homelessness-and-alcohol-use-disorders
#11
Susan E Collins, Emily Taylor, Connor Jones, Laura Haelsig, Véronique S Grazioli, Jessica L Mackelprang, Jessica Holttum, Molly Koker, Alyssa Hatsukami, Madeline Baker, Seema L Clifasefi
BACKGROUND: Alcohol use disorders (AUDs) are more prevalent among people who are homeless than in the general population. Thus, homeless individuals experience disproportionately high levels of alcohol-related problems and associated publicly funded criminal justice and healthcare system utilization. Available treatment services, however, are not effective at engaging and treating this population. To better tailor treatment services to their needs, it is imperative we understand this population's perceptions of their alcohol use...
July 25, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28742381/systemic-error-in-radiology
#12
Stephen Waite, Jinel Moore Scott, Alan Legasto, Srinivas Kolla, Brian Gale, Elizabeth A Krupinski
OBJECTIVE: Interpretive errors in diagnostic imaging result in significant patient morbidity and mortality, but the importance of errors and process failures in the imaging cycle other than during image interpretation is underappreciated. In this article, we describe these errors and potential solutions, providing a framework to improve patient safety and understand the changing roles of radiologists beyond image interpretation. CONCLUSION: For comprehensive improvements to health care delivery, other failures in the cycle besides diagnostic interpretive error-such as ordering inappropriate studies, PACS failures, and a lack of accurate clinician contact information (with resultant communication failure)-should be recognized as contributors to patient harm because they lead to wasted resources and delayed care...
July 25, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28742377/reducing-delay-in-diagnosis-multistage-recommendation-tracking
#13
Ben Wandtke, Sarah Gallagher
OBJECTIVE: The purpose of this study was to determine whether a multistage tracking system could improve communication between health care providers, reducing the risk of delay in diagnosis related to inconsistent communication and tracking of radiology follow-up recommendations. MATERIALS AND METHODS: Unconditional recommendations for imaging follow-up of all diagnostic imaging modalities excluding mammography (n = 589) were entered into a database and tracked through a multistage tracking system for 13 months...
July 25, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28742334/health-effects-of-dietary-oxidized-tyrosine-and-dityrosine-administration-in-mice-with-nutrimetabolomic-strategies
#14
Yuhui Yang, Hui Zhang, Biao Yan, Tianyu Zhang, Ying Gao, Yonghui Shi, Guowei Le
This study aims to investigate the health effects of long-term dietary oxidized tyrosine (O-Tyr) and its main product (dityrosine) administration on mice metabolism. Mice received daily intragastric administration of either O-Tyr (320 μg/kg body weight), dityrosine (Dityr, 320 μg/kg body weight) or saline for consecutive six weeks. Urine and plasma samples were analyzed by NMR-based metabolomics strategies. Body weight, clinical chemistry, oxidative damage indexes and histopathological data were obtained as complementary information...
July 25, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28742275/the-proteome-and-transcriptome-of-the-infectious-metacyclic-form-of-trypanosoma-brucei-define-quiescent-cells-primed-for-mammalian-invasion
#15
Romain Christiano, Nikolay G Kolev, Huafang Shi, Elisabetta Ullu, Tobias C Walther, Christian Tschudi
The infectious metacyclic forms of Trypanosoma brucei result from a complex development in the tsetse fly vector. When they infect mammals, they cause African sleeping sickness in humans. Due to scarcity of biological material and difficulties of the tsetse fly as an experimental system, very limited information is available concerning the gene expression profile of metacyclic forms. We used an in vitro system based on expressing the RNA binding protein 6 to obtain infectious metacyclics and determined their protein and mRNA repertoires by mass-spectrometry (MS) based proteomics and mRNA sequencing (RNA-Seq) in comparison to non-infectious procyclic trypanosomes...
July 25, 2017: Molecular Microbiology
https://www.readbyqxmd.com/read/28742259/off-label-use-of-rituximab-in-autoimmune-disease-in-the-top-end-of-the-northern-territory-2008-2016
#16
Sarah Wongseelashote, Vipin Tayal, Peter Francis Bourke
BACKGROUND: Rituximab, an anti-CD20 B cell depleting monoclonal antibody, is increasingly prescribed off-label for a range of autoimmune diseases. There has not previously been an audit of off-label rituximab use in the Northern Territory, where the majority of patients are Aboriginal. AIMS: To retrospectively evaluate off-label rituximab use in autoimmune diseases in the Top End of the Northern Territory. METHOD: We performed a retrospective audit of eight years of off-label rituximab use at the Royal Darwin Hospital, the sole tertiary referral centre for the Darwin, Katherine and East Arnhem regions...
July 25, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28742243/data-privacy-management-and-data-quality-monitoring-in-the-german-centre-for-cardiovascular-research-s-multicentre-translational-registry-for-cardiomyopathies-dzhk-torch
#17
Thea Schwaneberg, Kerstin Weitmann, Andreas Dösch, Claudia Seyler, Thomas Bahls, Lars Geidel, Dana Stahl, Mahsa Lee, Monika Kraus, Hugo A Katus, Wolfgang Hoffmann
AIMS: The multicentric TranslatiOnal Registry for CardiomyopatHies (TORCH) of the German Centre for Cardiovascular Research aims to recruit 2300 patients with non-ischemic cardiomyopthies. METHODS AND RESULTS: The investigations were performed after standard operating procedures. The data are collected in standardized electronic case report forms provided by the data holding of the central data management of the German Centre for Cardiovascular Research using secuTrial (interActive Systems GmbH, Berlin, Germany)...
July 18, 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/28742226/documentation-of-penicillin-adverse-drug-reactions-in-electronic-health-records-inconsistent-use-of-allergy-and-intolerance-labels
#18
Joshua M Inglis, Gillian E Caughey, William Smith, Sepehr Shakib
BACKGROUND: The majority of patients with penicillin allergy labels tolerate penicillins. Inappropriate avoidance of penicillin is associated with increased hospitalisation, infections and healthcare costs. AIMS: To examine the documentation of penicillin adverse drug reactions (ADR) in a large-scale hospital-based electronic health record. METHODS: Penicillin ADRs were extracted from 96,708 patient records in the Enterprise Patient Administration System in South Australia...
July 25, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28742111/axonal-outgrowth-neuropeptides-expression-and-receptors-tyrosine-kinase-phosphorylation-in-3d-organotypic-cultures-of-adult-dorsal-root-ganglia
#19
Estrela Neto, Cecília J Alves, Luís Leitão, Daniela M Sousa, Inês S Alencastre, Francisco Conceição, Meriem Lamghari
Limited knowledge from mechanistic studies on adult sensory neuronal activity was generated, to some extent, in recapitulated adult in vivo 3D microenvironment. To fill this gap there is a real need to better characterize the adult dorsal root ganglia (aDRG) organotypic cultures to make these in vitro systems exploitable for different approaches, ranging from basic neurobiology to regenerative therapies, to address the sensory nervous system in adult stage. We conducted a direct head-to-head comparison of aDRG and embryonic DRG (eDRG) organotypic culture focusing on axonal growth, neuropeptides expression and receptors tyrosine kinase (RTK) activation associated with neuronal survival, proliferation and differentiation...
2017: PloS One
https://www.readbyqxmd.com/read/28742091/multiple-visual-objects-are-sampled-sequentially
#20
Ole Jensen, Marlies E Vissers
When acting in a complex visual environment, it is essential to be able to flexibly allocate attention to parts of the visual scene that may contain goal-relevant information. The paper by Jia et al. provides novel evidence that our brains sequentially sample different objects in a visual scene. The results were obtained using "temporal response functions," in which unique electroencephalographic (EEG) signals corresponding to the processing of 2 continuously presented objects were isolated in an object-specific way...
July 24, 2017: PLoS Biology
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