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https://www.readbyqxmd.com/read/28528458/cardiac-amyloidosis-diagnosis-and-treatment-strategies
#1
REVIEW
Mirela Tuzovic, Eric H Yang, Arnold S Baas, Eugene C Depasquale, Mario C Deng, Daniel Cruz, Gabriel Vorobiof
Cardiac amyloidosis in the United States is most often due to myocardial infiltration by immunoglobulin protein, such as in AL amyloidosis, or by the protein transthyretin, such as in hereditary and senile amyloidosis. Cardiac amyloidosis often portends a poor prognosis especially in patients with systemic AL amyloidosis. Despite better understanding of the pathophysiology of amyloid, many patients are still diagnosed late in the disease course. This review investigates the current understanding and new research on the diagnosis and treatment strategies in patients with cardiac amyloidosis...
July 2017: Current Oncology Reports
https://www.readbyqxmd.com/read/28528380/the-rat-corticospinal-system-is-functionally-and-anatomically-segregated
#2
Rafael Olivares-Moreno, Yunuen Moreno-Lopez, Luis Concha, Guadalupe Martínez-Lorenzana, Miguel Condés-Lara, Matilde Cordero-Erausquin, Gerardo Rojas-Piloni
The descending corticospinal (CS) projection has been considered a key element for motor control, which results from direct and indirect modulation of spinal cord pre-motor interneurons in the intermediate gray matter of the spinal cord, which, in turn, influences motoneurons in the ventral horn. The CS tract (CST) is also involved in a selective and complex modulation of sensory information in the dorsal horn. However, little is known about the spinal network engaged by the CST and the organization of CS projections that may encode different cortical outputs to the spinal cord...
May 20, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28528373/the-association-between-primary-source-of-healthcare-coverage-and-colorectal-cancer-screening-among-us-veterans
#3
Folasade P May, Elizabeth M Yano, Dawn Provenzale, W Neil Steers, Donna L Washington
BACKGROUND: Colorectal cancer (CRC) is a deadly but largely preventable disease. Screening improves outcomes, but screening rates vary across healthcare coverage models. In the Veterans Health Administration (VA), screening rates are high; however, it is unknown how CRC screening rates compare for Veterans with other types of healthcare coverage. AIMS: To determine whether Veterans with Veteran-status-related coverage (VA, military, TRICARE) have higher rates of CRC screening than Veterans with alternate sources of healthcare coverage...
May 20, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28528371/assessment-of-the-psychometric-properties-of-the-eq-5d-3l-and-eq-5d-5l-instruments-in-psoriasis
#4
John Yfantopoulos, Athanasios Chantzaras, Stathis Kontodimas
The aim of this study was to assess the psychometric properties of the five-level (EQ-5D-5L) in comparison with the standard three-level (EQ-5D-3L) classification systems of the EQ-5D in a sample of psoriatic patients. Psoriatic subjects (n = 396) recruited from 16 private practicing centers from various areas of Greece self-completed the two EQ-5D versions and the Dermatology Life Quality Index, while information was also collected on socio-demographics, clinical characteristics and comorbidities. The EQ-5D-5L and EQ-5D-3L were evaluated in terms of agreement, feasibility, ceiling effects, redistribution properties, inconsistency, informativity, and convergent and known-groups validity...
May 20, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28528284/biomarkers-in-epilepsy-a-modelling-perspective
#5
Sven C van Dijkman, Rob A Voskuyl, Elizabeth C de Lange
Biomarkers can be categorised from type 0 (genotype or phenotype), through 6 (clinical scales), each level representing a part of the processes involved in the biological system and drug treatment. This classification facilitates the identification and connection of information required to fully (mathematically) model a disease and its treatment using integrated information from biomarkers. Two recent reviews thoroughly discussed the current status and development of biomarkers for epilepsy, but a path towards the integration of such biomarkers for the personalisation of anti-epileptic drug treatment is lacking...
May 17, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28528262/stable-isotope-tracing-of-ni-and-cu-pollution-in-north-east-norway-potentials-and-drawbacks
#6
Hana Šillerová, Vladislav Chrastný, Martina Vítková, Anna Francová, Jan Jehlička, Marissa R Gutsch, Jana Kocourková, Paul E Aspholm, Lars O Nilsson, Tore F Berglen, Henning K B Jensen, Michael Komárek
The use of Ni and Cu isotopes for tracing contamination sources in the environment remains a challenging task due to the limited information about the influence of various biogeochemical processes influencing stable isotope fractionation. This work focuses on a relatively simple system in north-east Norway with two possible endmembers (smelter-bedrock) and various environmental samples (snow, soil, lichens, PM10). In general, the whole area is enriched in heavy Ni and Cu isotopes highlighting the impact of the smelting activity...
May 18, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28528256/evaluation-of-artificial-time-series-microarray-data-for-dynamic-gene-regulatory-network-inference
#7
P Xenitidis, I Seimenis, S Kakolyris, A Adamopoulos
High-throughput technology like microarrays is widely used in the inference of gene regulatory networks (GRNs). We focused on time series data since we are interested in the dynamics of GRNs and the identification of dynamic networks. We evaluated the amount of information that exists in artificial time series microarray data and the ability of an inference process to produce accurate models based on them. We used dynamic artificial gene regulatory networks in order to create artificial microarray data. Key features that characterize microarray data such as the time separation of directly triggered genes, the percentage of directly triggered genes and the triggering function type were altered in order to reveal the limits that are imposed by the nature of microarray data on the inference process...
May 17, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28528137/fuzzy-dynamic-output-feedback-h%C3%A2-control-for-continuous-time-t-s-fuzzy-systems-under-imperfect-premise-matching
#8
Tao Zhao, Songyi Dian
This paper addresses a fuzzy dynamic output feedback H∞ control design problem for continuous-time nonlinear systems via T-S fuzzy model. The stability of the fuzzy closed-loop system which is formed by a T-S fuzzy model and a fuProd. Type: FTPzzy dynamic output feedback H∞ controller connected in a closed loop is investigated with Lyapunov stability theory. The proposed fuzzy controller does not share the same membership functions and number of rules with T-S fuzzy systems, which can enhance design flexibility...
May 17, 2017: ISA Transactions
https://www.readbyqxmd.com/read/28528114/postoperative-outcomes-of-two-and-three-dimensional-planning-in-orthognathic-surgery-a-comparative-study
#9
Ting-Yu Wu, Hsiu-Hsia Lin, Lun-Jou Lo, Cheng-Ting Ho
OBJECTIVE: Compared with conventional two-dimensional (2D) planning, three-dimensional (3D) planning in orthognathic surgery yields more accurate anatomical information and enables the precise positioning of maxillary and mandibular segments, particularly for patients with facial asymmetry. Accordingly, surgical outcomes achieved using 3D planning should be superior. This study determined the differences between the 2D and 3D planning techniques by comparing their surgical outcomes. MATERIALS AND METHODS: In this retrospective study, patients who underwent surgery following the traditional 2D planning technique were classified into the 2D planning group...
April 23, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28528092/structural-strength-analysis-of-amorphous-trehalose-maltodextrin-systems
#10
V A Maidannyk, B Nurhadi, Y H Roos
Fundamental knowledge of physical state of materials gives practically important information for food, biological and pharmaceutical industry. Based on Williams-Landel-Ferry (WLF) equation, the strength concept was introduced. This concept provides a simple parameter, S, to express resistance of solids to flow above the glass transition temperature. To develop this approach, miscible trehalose-maltodextrin (0:100; 20:80; 40:60; 60:40; 80:20 and 100:0) systems with different ratios of components were used in the present study...
June 2017: Food Research International
https://www.readbyqxmd.com/read/28527950/the-building-blocks-of-drinking-experience-across-men-and-women-a-case-study-with-craft-and-industrial-beers
#11
Carlos Gómez-Corona, Héctor B Escalona-Buendía, Sylvie Chollet, Dominique Valentin
In today's market, every product seems to be marked by the label of "experience". It is expected that successful products give the consumer "extraordinary experiences". The research in consumption experience is growing, but much work still needs to be done to understand the food and beverage experience. A qualitative study was conducted using contextual focus groups to explore the building blocks of consumers' drinking experience of industrial and craft beers. The results show that drinking experience is shaped by our cognitive, sensory or affective systems, especially during the core consumption experience...
May 17, 2017: Appetite
https://www.readbyqxmd.com/read/28527861/cellular-computational-generalized-neuron-network-for-frequency-situational-intelligence-in-a-multi-machine-power-system
#12
Yawei Wei, Ganesh Kumar Venayagamoorthy
To prevent large interconnected power system from a cascading failure, brownout or even blackout, grid operators require access to faster than real-time information to make appropriate just-in-time control decisions. However, the communication and computational system limitations of currently used supervisory control and data acquisition (SCADA) system can only deliver delayed information. However, the deployment of synchrophasor measurement devices makes it possible to capture and visualize, in near-real-time, grid operational data with extra granularity...
April 4, 2017: Neural Networks: the Official Journal of the International Neural Network Society
https://www.readbyqxmd.com/read/28527794/farmers-preferences-for-automatic-lameness-detection-systems-in-dairy-cattle
#13
T Van De Gucht, W Saeys, A Van Nuffel, L Pluym, K Piccart, L Lauwers, J Vangeyte, S Van Weyenberg
As lameness is a major health problem in dairy herds, a lot of attention goes to the development of automated lameness-detection systems. Few systems have made it to the market, as most are currently still in development. To get these systems ready for practice, developers need to define which system characteristics are important for the farmers as end users. In this study, farmers' preferences for the different characteristics of proposed lameness-detection systems were investigated. In addition, the influence of sociodemographic and farm characteristics on farmers' preferences was assessed...
May 17, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28527792/3d-cmro2-mapping-in-human-brain-with-direct-17-o-mri-comparison-of-conventional-and-proton-constrained-reconstructions
#14
Dmitry Kurzhunov, Robert Borowiak, Marco Reisert, Axel Joachim Krafft, Ali Caglar Özen, Michael Bock
Oxygen metabolism is altered in brain tumor regions and is quantified by the cerebral metabolic rate of oxygen consumption (CMRO2). Direct dynamic (17)O MRI with inhalation of isotopically enriched (17)O2 gas can be used to quantify CMRO2; however, pixel-wise CMRO2 quantification in human brain is challenging due to low natural abundance of (17)O isotope and, thus, the low signal-to-noise ratio (SNR) of (17)O MR images. To test the feasibility CMRO2 mapping at a clinical 3 T MRI system, a new iterative reconstruction was proposed, which uses the edge information contained in a co-registered (1)H gradient image to construct a non-homogeneous anisotropic diffusion (AD) filter...
May 17, 2017: NeuroImage
https://www.readbyqxmd.com/read/28527790/visual-cortex-signals-a-mismatch-between-regularity-of-auditory-and-visual-streams
#15
Michael Andric, Ben Davis, Uri Hasson
Understanding how humans code for and respond to environmental uncertainty/regularity is a question shared by current computational and neurobiological approaches to human cognition. To date, studies investigating neurobiological systems that track input uncertainty have examined responses to uni-sensory streams. It is not known, however, whether there exist brain systems that combine information about the regularity of input streams presented to different senses. We report an fMRI study that aimed to identify brain systems that relate statistical information across sensory modalities...
May 17, 2017: NeuroImage
https://www.readbyqxmd.com/read/28527573/retinoid-related-orphan-receptor-%C3%AE-and-transcriptional-control-of-neuronal-differentiation
#16
Hong Liu, Michihiko Aramaki, Yulong Fu, Douglas Forrest
The ability to generate neuronal diversity is central to the function of the nervous system. Here we discuss the key neurodevelopmental roles of retinoid-related orphan receptor β (RORβ) encoded by the Rorb (Nr1f2) gene. Recent studies have reported loss of function of the human RORB gene in cases of familial epilepsy and intellectual disability. Principal sites of expression of the Rorb gene in model species include sensory organs, the spinal cord, and brain regions that process sensory and circadian information...
2017: Current Topics in Developmental Biology
https://www.readbyqxmd.com/read/28527507/it-takes-two-to-tango-engaging-patients-and-providers-with-portals
#17
REVIEW
Sachin D Shah, David Liebovitz
Patient portals are designed to be tools to more fully engage patients in their health care and help enable them to better manage their own health information. As the U.S. health care system rapidly adopted electronic health records (EHRs) over the past decade, many with linked patient portals, enthusiasm and expectations for this new technology as a means to engage and empower patients grew. Most patient portals have a set of core features designed to facilitate health care transactions, information tracking, and communication with care team members...
May 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28527506/technology-enabled-population-health-management-two-communities-use-of-an-electronic-care-alert-system
#18
REVIEW
Todd Rowland, Jill Nielsen-Farrell, Kathy Church, Barbara Riddell
Population health management is an approach to improve the health outcomes of a specific group of people, such as frequent users of the emergency department or those at high-risk for hospital admissions. When combined with quality improvement strategies, the targeted application of health information exchange and health information technology (health IT) can swiftly move health care systems and providers from basic to advanced population health management. One such tool is an electronic alert system (alert system), which informs a provider or site about a patient's visit to the emergency department or hospital admission on a daily basis...
May 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28527502/selection-and-implementation-of-an-electronic-health-record
#19
REVIEW
Grant S Fletcher, Thomas H Payne
Electronic health records (EHRs) are now the standard of practice in most communities, because of transition to reimbursement that increasingly focuses on risk sharing and quality measurement, and government EHR incentive programs. The selection and implementation of an EHR is one of the most important decisions a practice faces. Organizing the search for an EHR that fits a practice, negotiating a contract, planning and successfully implementing an EHR are best accomplished with a well-informed, strong, multidisciplinary team using project management techniques...
May 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28527499/it-is-from-mars-and-physicians-from-venus-bridging-the-gap
#20
REVIEW
Mark E Huang
With increasing adoption of electronic health records (EHRs) and legislative mandates for its use within the United States, collaboration between physicians and information technology (IT) staff is essential. Current challenges that physicians face include addressing EHR usability, system performance, adequate training, issue resolution, regulatory compliance, and lack of awareness of IT roles. These challenges lead to gaps in communication between clinicians and IT staff. Strategies to improve collaboration between physicians and IT staff include increasing physician involvement with health information technology software development, involvement with legislative regulations and standards, IT project implementation, as well as system stabilization and optimization...
May 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
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