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https://www.readbyqxmd.com/read/28803389/gastrointestinal-manifestations-of-stat3-deficient-hyper-ige-syndrome
#1
Manish Arora, Preet Bagi, Anna Strongin, Jennifer Heimall, Xiongce Zhao, Monica G Lawrence, Apurva Trivedi, Carolyn Henderson, Amy Hsu, Martha Quezado, David E Kleiner, Aradhana M Venkatesan, Steven M Holland, Alexandra F Freeman, Theo Heller
OBJECTIVE: STAT 3 deficiency (autosomal dominant hyper immunoglobulin E syndrome (AD-HIES)) is a primary immunodeficiency disorder with multi-organ involvement caused by dominant negative signal transducer and activator of transcription gene 3 (STAT3) mutations. We sought to describe the gastrointestinal (GI) manifestations of this disease. METHODS: Seventy subjects aged five to 60 years with a molecular diagnosis of AD-HIES were evaluated at the National Institutes of Health (NIH)...
August 13, 2017: Journal of Clinical Immunology
https://www.readbyqxmd.com/read/28800288/population-based-study-of-the-national-implementation-of-therapeutic-hypothermia-in-infants-with-hypoxic-ischemic-encephalopathy
#2
Juan Arnaez, Alfredo García-Alix, Gemma Arca, Sonia Caserío, Eva Valverde, M Teresa Moral, Isabel Benavente-Fernández, Simón Lubián-López
Data on the incidence of hypoxic-ischemic encephalopathy (HIE) in the first 6 hours of life together with the implementation of therapeutic hypothermia (TH) are relevant to delineate actions to achieve the lowest rates of neonatal mortality, morbidity, and long-term impact on health associated with HIE. This is population-based national survey study, including newborns ≥35 weeks of gestation with moderate-to-severe HIE from all level III neonatal care units, to provide the incidence of HIE for the period 2012-2013, and the implementation of TH up to June 2015 in Spain...
August 11, 2017: Therapeutic Hypothermia and Temperature Management
https://www.readbyqxmd.com/read/28797191/systematic-review-seeking-erythropoietin-role-for-neuroprotection-in-neonates-with-hypoxic-ischemic-encephalopathy-presently-where-do-we-stand
#3
Bhawan Deep Garg, Deepak Sharma, Anju Bansal
BACKGROUND: Hypoxic ischemic encephalopathy (HIE) is one of the leading causes of neonatal mortality in developing countries and leads to some form of neuro-developmental disability in latter part of life. AIMS: To evaluate the role of erythropoietin (EPO) in neuro-protection for term newborn having HIE. METHOD: The literature search was done for various trials by searching the Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, EMBASE, Web of science, Scopus, Index Copernicus, and other data base...
August 10, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28796992/abnormal-interhemispheric-synchrony-in-neonatal-hypoxic-ischemic-encephalopathy-a-retrospective-pilot-study
#4
Elise Leroy-Terquem, Anne Isabelle Vermersch, Pauline Dean, Ziad Assaf, Nathalie Boddaert, Alexandre Lapillonne, Jean-François Magny
BACKGROUND: Abnormal interhemispheric synchrony has been described in many clinical compromises in brain function, but its prognostic value in neonatal hypoxic-ischemic encephalopathy (HIE) is unknown. OBJECTIVES: The study aimed at describing the frequency of abnormal interhemispheric synchrony in infants with HIE and to explore its prognostic value. The main outcome was survival without major disabilities. METHODS: We performed a single-center retrospective cohort study and enrolled 40 neonates with HIE who underwent hypothermia...
August 11, 2017: Neonatology
https://www.readbyqxmd.com/read/28795155/detection-of-urine-dna-markers-for-monitoring-recurrent-hepatocellular-carcinoma
#5
Hie-Won Hann, Surbhi Jain, Grace Park, Jamin D Steffen, Wei Song, Ying-Hsiu Su
AIM: This study aimed to explore the potential of detecting hepatocellular carcinoma (HCC)-associated DNA markers, TP53 249T mutations and aberrant methylation of RASSF1A and GSTP1 genes, for monitoring HCC recurrence. HCC remains a leading cause of death worldwide, with one of the fastest growing incidence rates in the US. While treatment options are available and new ones emerging, there remains a poor prognosis of this disease mostly due to its late diagnosis and high recurrence rate...
2017: Hepatoma Research
https://www.readbyqxmd.com/read/28792689/predictive-value-of-neurodevelopmental-outcome-and-serum-tau-protein-level-in-neonates-with-hypoxic-ischemic-encephalopathy
#6
Hong-Yan Lv, Su-Jing Wu, Xiu-Ling Gu, Qiu-Li Wang, Peng-Shun Ren, Yan Ma, Li-Ying Peng, Lin-Hong Jin, Lian-Xiang Li
BACKGROUND: Tau protein is s specific protein expressed by neurons in the central nervous system. Elevated serum Tau protein is associated with many diseases of the central nervous system. The serum Tau protein level in neonates with hypoxic ischemic encephalopathy (HIE) is still poorly understood. METHODS: Forty-one human neonates with HIE and thirty-five healthy neonates (control group) within 24 hours after birth were studied. Tau protein in serum was detected by enzyme-linked immunosorbent assay...
July 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28780000/systemic-infusions-of-anti-interleukin-1%C3%AE-neutralizing-antibodies-reduce-short-term-brain-injury-after-cerebral-ischemia-in-the-ovine-fetus
#7
Xiaodi Chen, Virginia Hovanesian, Syed Naqvi, Yow-Pin Lim, Richard Tucker, John E Donahue, Edward G Stopa, Barbara S Stonestreet
Perinatal hypoxic-ischemic reperfusion (I/R)-related brain injury is a leading cause of neurologic morbidity and life-long disability in children. Infants exposed to I/R brain injury develop long-term cognitive and behavioral deficits, placing a large burden on parents and society. Therapeutic strategies are currently not available for infants with I/R brain damage, except for hypothermia, which can only be used in full term infants with hypoxic-ischemic encephalopathy (HIE). Moreover, hypothermia is only partially protective...
August 2, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28772198/cerebral-regional-oxygen-saturation-trends-in-infants-with-hypoxic-ischemic-encephalopathy
#8
Siddharth V Jain, Lindsay Pagano, Maria Gillam-Krakauer, James C Slaughter, Sumit Pruthi, Barbara Engelhardt
BACKGROUND: Neurological outcomes in neonatal hypoxic-ischemic encephalopathy (HIE) continue to be sub-optimal despite therapeutic hypothermia (TH). Cerebral near-infrared spectroscopy provides real-time regional oxygen saturation (CrSO2) that may be a marker of adverse MRI findings and neurodevelopmental outcomes. AIM: The aim of this study was to examine the value of CrSO2 monitoring in infants with HIE undergoing TH. STUDY DESIGN AND SUBJECTS: In this prospective study, CrSO2 was continuously recorded in 21 infants with HIE admitted for TH...
July 31, 2017: Early Human Development
https://www.readbyqxmd.com/read/28770451/pharmacotherapy-for-seizures-in-neonates-with-hypoxic-ischemic-encephalopathy
#9
REVIEW
Elissa Yozawitz, Arthur Stacey, Ronit M Pressler
Seizures are common in neonates with moderate and severe hypoxic ischemic encephalopathy (HIE) and are associated with worse outcomes, independent of HIE severity. In contrast to adults and older children, no new drugs have been licensed for treatment of neonatal seizures over the last 50 years, because of a lack of controlled clinical trials. Hence, many antiseizure medications licensed in older children and adults are used off-label for neonatal seizure, which is associated with potential risks of adverse effects during a period when the brain is particularly vulnerable...
August 2, 2017: Paediatric Drugs
https://www.readbyqxmd.com/read/28764944/-incidence-of-hypoxic-ischaemic-encephalopathy-and-use-of-therapeutic-hypothermia-in-spain
#10
Juan Arnaez, Alfredo García-Alix, Gemma Arca, Eva Valverde, Sonia Caserío, M Teresa Moral, Isabel Benavente-Fernández, Simón Lubián-López
INTRODUCTION: There are no data on the incidence of hypoxic-ischaemic encephalopathy (HIE) and the implementation of therapeutic hypothermia (TH) in Spain. METHODS: This is a cross-sectional, national study, performed using an on-line questionnaire targeting level III neonatal care units in Spain. Participants were requested to provide data of all newborns ≥ 35 weeks of gestational age diagnosed with moderate-severe HIE over a two year-period (2012-2013), and of the implementation of TH up to June 2015...
July 29, 2017: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/28756088/protein-s100b-in-umbilical-cord-blood-as-a-potential-biomarker-of-hypoxic-ischemic-encephalopathy-in-asphyxiated-newborns
#11
Mehreen Zaigham, Fredrik Lundberg, Per Olofsson
BACKGROUND: Neonatal hypoxic ischemic encephalopathy (HIE) is a devastating condition resulting from a sustained lack of oxygen during birth. The interest in identifying a relevant biomarker of HIE has thrown into limelight the role of protein S100B as a clinical diagnostic marker of hypoxic brain damage in neonates. AIMS: To evaluate the diagnostic value of protein S100B, measured in umbilical cord blood immediately after birth, as a useful biomarker in the diagnosis of HIE Sarnat stages II-III as well as a marker for long-term mortality and morbidity...
July 27, 2017: Early Human Development
https://www.readbyqxmd.com/read/28750727/safety-of-moderate-hypothermia-for-perinatal-hypoxic-ischemic-encephalopathy-a-meta-analysis
#12
Wei Zhang, Jing Ma, Quzhen Danzeng, Yue Tang, Meizhu Lu, Yan Kang
BACKGROUND: We investigated the safety of therapeutic hypothermia during intervention in infants with hypoxic-ischemic encephalopathy (HIE). METHODS: The MEDLINE, EMBASE, PubMed, and the Cochrane Central Register of Controlled Trials from onset to November 30, 2016 were searched for studies on perinatal HIE. Randomized controlled trials comparing the use of therapeutic hypothermia with normothermia for perinatal HIE were included in the study. Safety and efficacy data for therapeutic hypothermia in 1806 infants with HIE were included in this meta-analysis...
May 5, 2017: Pediatric Neurology
https://www.readbyqxmd.com/read/28745563/validity-of-routinely-collected-data-in-identifying-hip-fractures-at-a-major-tertiary-hospital-in-australia
#13
Lieu Thi Thuy Trinh, Helen Achat, Sze Ming Loh, Robert Pascoe, Hassan Assareh, Joanne Stubbs, Veth Guevarra
OBJECTIVES: To examine the validity of routinely collected data in identifying hip fractures (HFs) and to identify factors associated with incorrect coding. METHOD: In a prospective cohort study between January 2014 and June 2016, HFs were identified using physician diagnosis and diagnostic imaging and were recorded in a Registry. Records of HFs in the health information exchange (HIE) were identified using International Statistical Classification of Diseases and Related Health Problems, Tenth Revision, Australian Modification/Australian Classification of Health Interventions/Australian Coding Standards codes...
January 1, 2017: HIM Journal
https://www.readbyqxmd.com/read/28742101/urban-rural-differences-in-disability-free-life-expectancy-in-bangladesh-using-the-2010-hies-data
#14
Md Shariful Islam, Md Ismail Tareque, Md Nazrul Islam Mondal, Ahbab Mohammad Fazle Rabbi, Hafiz T A Khan, Sharifa Begum
BACKGROUND: Research on health expectancy has been carried out in Bangladesh but none of it has examined the differences in Disability-Free Life Expectancy (DFLE) between urban and rural setting in context of rapid urbanization of Bangladesh in past decades. OBJECTIVES: The present study aims to estimate DFLE for people of all ages living in urban and rural areas in Bangladesh, and to examine the differences in DFLE between these two areas. METHODS: Data from the Sample Vital Registration System 2010 and the Bangladesh Household Income and Expenditure Survey (HIES) 2010 were used in this study...
2017: PloS One
https://www.readbyqxmd.com/read/28741799/multicenter-study-for-brain-body-hypothermia-for-hie-investigation-of-changes-in-hmgb-1
#15
Toshihiko Nakamura, Hideomi Asanuma, Satoshi Kusuda, Ken Imai, Shigeharu Hosono, Ryota Kato, Satoshi Suzuki, Kyoko Yokoi, Minoru Kokubo, Shingo Yamada, Takashi Kamohara
BACKGROUND: We measured changes in the blood levels of high mobility group box-1 (HMGB-1) at 24-hour intervals in neonates treated with brain/body hypothermia (BHT) for hypoxic ischemic encephalopathy (HIE), to evaluate the usefulness of HMGB-1 levels for determining outcomes. METHODS: We studied 15 neonates with HIE who underwent BHT (BHT (+) group) and 6 neonates with HIE who did not (BHT (-) group). We recorded HMGB-1 changes at 24-hour intervals, creatinine phosphokinase (CK), and the resistance index of the anterior cerebral artery (ACA-RI)...
July 25, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28741035/biomarkers-of-hepatic-injury-and-function-in-neonatal-hypoxic-ischemic-encephalopathy-and-with-therapeutic-hypothermia
#16
Hemananda Muniraman, Danielle Gardner, Jane Skinner, Anna Paweletz, Anitha Vayalakkad, Ying Hui Chee, Clare Clifford, Sunil Sanka, Vidheya Venkatesh, Anna Curley, Suresh Victor, Mark A Turner, Paul Clarke
Therapeutic hypothermia (TH) is now provided as standard care to infants with moderate-severe hypoxic ischemic encephalopathy (HIE). The role of TH in limiting neuronal injury is well recognized, but its effect on hepatic injury which occurs frequently in neonatal HIE is not known. Our objective was to characterize biomarkers of liver injury and function in the setting of neonatal HIE and to describe whether HIE severity and provision of TH influence these hepatic biomarkers. We performed a multicenter retrospective study and compared hepatic biomarkers obtained during the first postnatal week, according to the severity of HIE and whether treated with TH...
July 24, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28733155/implementation-of-a-health-information-exchange-into-community-pharmacy-workflow
#17
Kenneth C Hohmeier, Christina A Spivey, Samantha Boldin, Tara B Moore, Marie Chisholm-Burns
OBJECTIVES: To explore the feasibility and report preliminary outcomes of the integration of a health information exchange (HIE) into community pharmacy workflow clinical service delivery. SETTING: Independent pharmacy in eastern Tennessee. PRACTICE DESCRIPTION: The pharmacy offers medication reconciliation services via HIE access, as well as other clinical pharmacy services. The average number of prescriptions filled weekly is 1900, and staffing included 3...
July 18, 2017: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/28730122/corneal-blindness-and-current-major-treatment-concern-graft-scarcity
#18
REVIEW
Kah Hie Wong, Ka Wai Kam, Li Jia Chen, Alvin L Young
According to World Health Organization, the global prevalence of blindness in 2010 was 39 million people, among which 4% were due to corneal opacities. Often, the sole resort for visual restoration of patients with damaged corneas is corneal transplantation. However, despite rapid developments of surgical techniques, instrumentations and immunosuppressive agents, corneal blindness remains a prevalent global health issue. This is largely due to the scarcity of good quality corneal grafts. In this review, the causes of corneal blindness, its major treatment options, and the major contributory factors of corneal graft scarcity with potential solutions are discussed...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28715260/does-adding-information-on-toxic-constituents-to-cigarette-pack-warnings-increase-smokers-perceptions-about-the-health-risks-of-smoking-a-longitudinal-study-in-australia-canada-mexico-and-the-united-states
#19
Yoo Jin Cho, James F Thrasher, Kamala Swayampakala, Isaac Lipkus, David Hammond, Kenneth Michael Cummings, Ron Borland, Hua-Hie Yong, James W Hardin
BACKGROUND: Health warning labels (HWLs) on cigarette packs in Australia, Canada, Mexico, and the United States include varying information about toxic cigarette smoke constituents and smoking-related health risks. HWL information changed more recently in Australia, Canada, and Mexico than in the United States. AIMS: To investigate whether smokers' knowledge of toxic constituents and perceived smoking-related risks increased after adding this information to HWLs and how knowledge of toxic constituents is associated with perceptions of smoking-related risks...
June 1, 2017: Health Education & Behavior: the Official Publication of the Society for Public Health Education
https://www.readbyqxmd.com/read/28706860/targeted-temperature-management-in-neurological-intensive-care-unit
#20
REVIEW
Sombat Muengtaweepongsa, Winchana Srivilaithon
Targeted temperature management (TTM) shows the most promising neuroprotective therapy against hypoxic/ischemic encephalopathy (HIE). In addition, TTM is also useful for treatment of elevated intracranial pressure (ICP). HIE and elevated ICP are common catastrophic conditions in patients admitted in Neurologic intensive care unit (ICU). The most common cause of HIE is cardiac arrest. Randomized control trials demonstrate clinical benefits of TTM in patients with post-cardiac arrest. Although clinical benefit of ICP control by TTM in some specific critical condition, for an example in traumatic brain injury, is still controversial, efficacy of ICP control by TTM is confirmed by both in vivo and in vitro studies...
June 26, 2017: World Journal of Methodology
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