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https://www.readbyqxmd.com/read/29153922/e-health-in-switzerland-the-laborious-adoption-of-the-federal-law-on-electronic-health-records-ehr-and-health-information-exchange-hie-networks
#1
Carlo De Pietro, Igor Francetic
Within the framework of a broader e-health strategy launched a decade ago, in 2015 Switzerland passed a new federal law on patients' electronic health records (EHR). The reform requires hospitals to adopt interoperable EHRs to facilitate data sharing and cooperation among healthcare providers, ultimately contributing to improvements in quality of care and efficiency in the health system. Adoption is voluntary for ambulatories and private practices, that may however be pushed towards EHRs by patients. The latter have complete discretion in the choice of the health information to share...
November 10, 2017: Health Policy
https://www.readbyqxmd.com/read/29138115/active-forms-of-akt-and-erk-are-dominant-in-the-cerebral-cortex-of-newborn-pigs-that-are-unaffected-by-asphyxia
#2
Viktória Kovács, Valéria Tóth-Szűki, János Németh, Viktória Varga, Gábor Remzső, Ferenc Domoki
AIMS: Perinatal asphyxia (PA) often results in hypoxic-ischemic encephalopathy (HIE) in term neonates. Introduction of therapeutic hypothermia improved HIE outcome, but further neuroprotective therapies are still warranted. The present study sought to determine the feasibility of the activation of the cytoprotective PI-3-K/Akt and the MAPK/ERK signaling pathways in the subacute phase of HIE development in a translational newborn pig PA/HIE model. MAIN METHODS: Phosphorylated and total levels of Akt and ERK were determined by Western blotting in brain samples obtained from untreated naive, time control, and PA/HIE animals at 24-48h survival (n=3-3-6,respectively)...
November 11, 2017: Life Sciences
https://www.readbyqxmd.com/read/29136169/disparagement-of-health-warning-labels-on-cigarette-packages-and-cessation-attempts-results-from-four-countries
#3
Amira Osman, James F Thrasher, Hua-Hie Yong, Edna Arillo-Santillán, David Hammond
Health warning labels (HWLs) on cigarette packs that use strong fear appeals may evoke defensive responses including acts of disparaging the warnings. Whether warning disparagement undermines HWL effectiveness remains unclear. We assessed correlates of one type of HWL disparagement and its association with subsequent cessation attempts. Longitudinal data (2012-14) on adult smokers from Australia, Canada, Mexico and the United States (US) were analyzed. HWL disparagement was assessed as the frequency of making fun of HWLs in the past month...
November 10, 2017: Health Education Research
https://www.readbyqxmd.com/read/29112164/effect-of-intranasally-delivered-rh-vegf165-on-angiogenesis-following-cerebral-hypoxia-ischemia-in-the-cerebral-cortex-of-newborn-piglets
#4
Amit Jain, Panagiotis Kratimenos, Ioannis Koutroulis, Amishi Jain, Amulya Buddhavarapu, Jahan Ara
BACKGROUND: Vascular endothelial growth factor (VEGF) stimulates vascular genesis and angiogenesis. Cerebral Hypoxia-Ischemia (HI) leads to the reduction of vasculature in the cerebral cortex of newborn piglets. OBJECTIVE: The present study tests the hypothesis that post-hypoxia intranasal administration of recombinant human VEGF165 (rh-VEGF165) for 3 days increases the vascular density in the cerebral cortex of newborn piglets without promoting neovascularization...
November 7, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29106555/falling-short-how-state-laws-can-address-health-information-exchange-barriers-and-enablers
#5
Cason D Schmit, Sarah A Wetter, Bita A Kash
Objective: Research on the implementation of health information exchange (HIE) organizations has identified both positive and negative effects of laws relating to governance, incentives, mandates, sustainability, stakeholder participation, patient engagement, privacy, confidentiality, and security. We fill a substantial research gap by describing whether comprehensive state and territorial HIE legal frameworks address identified legal facilitators and barriers. Materials and Methods: We used the Westlaw database to identify state and territorial laws relating to HIEs in effect on June 7, 2016 (53 jurisdictions)...
November 2, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29105819/neuroprotective-effect-of-licochalcone-a-against-oxygen-glucose-deprivation-reperfusion-in-rat-primary-cortical-neurons-by-attenuating-oxidative-stress-injury-and-inflammatory-response-via-the-sirt1-nrf2-pathway
#6
Xiaohong Liu, Ying Ma, Xiaodi Wei, Ting Fan
Perinatal hypoxic-ischemic encephalopathy (HIE) is a leading cause of neonatal death and neurological disability. Oxidative stress and neuroinflammation are typical pathogenic factors of HIE. Licochalcone A (LCA) exerts various biological properties, including anti-inflammatory and antioxidant activities. However, no data have been reported to elucidate the role of LCA in the development of HIE. In the present study, primary cultured rat cortical neurons were exposed to oxygen-glucose deprivation/reoxygenation (OGD/R) in vitro to simulate the in vivo situation of neonatal HIE...
November 6, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29096946/path-analysis-of-warning-label-effects-on-negative-emotions-and-quit-attempts-a-longitudinal-study-of-smokers-in-australia-canada-mexico-and-the-us
#7
Yoo Jin Cho, James F Thrasher, Hua-Hie Yong, André Salem Szklo, Richard J O'Connor, Maansi Bansal-Travers, David Hammond, Geoffrey T Fong, James Hardin, Ron Borland
BACKGROUND: Cigarette pack health warning labels can elicit negative emotions among smokers, yet little is known about how these negative emotions influence behavior change. OBJECTIVE: Guided by psychological theories emphasizing the role of emotions on risk concern and behavior change, we investigated whether smokers who reported stronger negative emotional responses when viewing warnings reported stronger responses to warnings in daily life and were more likely to try to quit at follow-up...
October 12, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/29095369/a-population-ecology-perspective-on-the-functioning-and-future-of-health-information-organizations
#8
Joshua R Vest, Nir Menachemi
BACKGROUND: Increasingly, health care providers need to exchange information to meet policy expectations and business needs. A variety of health information organizations (HIOs) provide services to facilitate health information exchange (HIE). However, the future of these organizations is unclear. PURPOSE: The aim of this study was to explore the environmental context, potential futures, and survivability of community HIOs, enterprise HIEs, and electronic health record vendor-mediated exchange using the population ecology theory...
November 1, 2017: Health Care Management Review
https://www.readbyqxmd.com/read/29093656/functional-defects-in-type-3-innate-lymphoid-cells-and-classical-monocytes-in-a-patient-with-hyper-ige-syndrome
#9
Yuna Chang, Sung-Yoon Kang, Jihyun Kim, Hye-Ryun Kang, Hye Young Kim
Hyper-IgE syndrome (HIES) is a very rare primary immune deficiency characterized by elevated serum IgE levels, recurrent bacterial infections, chronic dermatitis, and connective tissue abnormalities. Autosomal dominant (AD) HIES involves a mutation in signal transducer and activator of transcription 3 (STAT3) that leads to an impaired TH17 response. STAT3 signaling is also involved in the function of RORγt(+) type 3 innate lymphoid cells (ILC3s) and RORγt(+)TH17 cells. The aim of this study was to investigate the role of innate immune cells such as innate lymphoid cells (ILCs), granulocytes, and monocytes in a patient with HIES...
October 2017: Immune Network
https://www.readbyqxmd.com/read/29081419/saccadic-dysfunction-in-patients-with-hypoxic-ischemic-encephalopathy
#10
Elena L Teslenko, Elena V Damyanovich, Ilija Damjanović, Zoran Gačić, Boris K Baziyan
Electrophysiological monitoring of saccadic eye movements in patients with hypoxic-ischemic encephalopathy (HIE) was carried out. Externally guided saccades (prosaccades) were recorded using a patented hardware-software complex for studying the subject's physical activity. Recordings were performed in two independent experimental procedures - for saccades separately and when they were in coordination with the motion of head and hand. In both cases statistically significant differences in latent periods and durations of saccadic eye movements were noticed in HIE patients in comparison with healthy subjects of the same age group (p<0...
October 25, 2017: Journal of Integrative Neuroscience
https://www.readbyqxmd.com/read/29069937/the-safety-of-high-dose-insulin-euglycaemia-therapy-in-toxin-induced-cardiac-toxicity
#11
Colin B Page, Nicole M Ryan, Geoffrey K Isbister
CONTEXT: High-dose insulin euglycaemia (HIE) is recommended in the management of toxin-induced cardiac toxicity, with increasing insulin doses now being used. We aimed to investigate the safety of HIE in toxin-induced cardiac toxicity. METHODS: This was a retrospective review of cases from two clinical toxicology units. Demographics, toxin(s) ingested, clinical effects, investigations (serum glucose, electrolytes), treatments (insulin, glucose, electrolyte replacement), length of stay (LOS) and outcomes were extracted from the patients' medical records...
October 26, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/29064865/head-impact-exposure-in-youth-soccer-and-variation-by-age-and-sex
#12
Sara P D Chrisman, Beth E Ebel, Elizabeth Stein, Sarah J Lowry, Frederick P Rivara
OBJECTIVE: To examine variation in head impact exposure (HIE) by age and sex in youth soccer. DESIGN: Prospective cohort study. SETTING AND PARTICIPANTS: Youth soccer athletes (11-14 years old) in local clubs. EXPOSURES: Age and sex. OUTCOME MEASURES: Head impact exposure measured using adhesive-mounted accelerometers during 1 month of soccer. RESULTS: Forty-six youth athletes (54% female) participated...
October 20, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/29063960/neurodevelopmental-outcome-in-survivors-of-hypoxic-ischemic-encephalopathy-without-cerebral-palsy
#13
Breda C Hayes, Elaine Doherty, Andrea Grehan, Cathy Madigan, Cliona McGarvey, Siobhan Mulvany, Tom G Matthews, Mary D King
To access outcome following hypoxic ischemic encephalopathy (HIE), survivors without cerebral palsy were invited for formal developmental assessment. Children aged ≥ 42 months were assessed using the NEPSY-2, Movement Assessment Battery for Children 2 (Movement ABC-2), Behavior Rating Inventory of Executive Function, and the Child Behavior Checklist. Children aged < 42 months were assessed using the Bayley Scales of Infant and Toddler Development, Third Edition (BSITD-3). One hundred forty-six children attended for assessments [Grade 1 (112), Grade 2 (33), and Grade 3 (1)]...
October 24, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29063541/best-paper-selection
#14
(no author information available yet)
Bahous MC, Shadmi E. Health information exchange and information gaps in referrals to a pediatric emergency department. Int J Med Inform 2016;87:68-74 https://linkinghub.elsevier.com/retrieve/pii/S1386-5056(15)30078-2 Esmaeilzadeh P, Sambasivan M. Health Information Exchange (HIE): A literature review, assimilation pattern and a proposed classification for a new policy approach. J Biomed Inform 2016;64:74-86 http://www.sciencedirect.com/science/article/pii/S1532046416301241?via%3Dihub Massoudi BL, Marcial LH, Tant E, Adler-Milstein J, West SL...
August 2017: Yearbook of Medical Informatics
https://www.readbyqxmd.com/read/29053702/the-effects-of-adding-prophylactic-phenobarbital-to-therapeutic-hypothermia-in-the-term-equivalent-hypoxic-ischemic-rat
#15
Sushma Krishna, Alexandra Hutton, Eric Aronowitz, Holly Moore, Susan J Vannucci
BackgroundHypoxic-ischemic encephalopathy (HIE) is a major cause of neonatal morbidity and mortality. Therapeutic hypothermia (TH) is the only available intervention, but neuroprotection is incomplete and variable. Seizures are common in infants with HIE undergoing TH and may worsen outcome. Phenobarbital is sometimes added, although use of prophylactic phenobarbital is controversial in the neonate. We hypothesize that prophylactic phenobarbital (PB) will not reduce, and may enhance, the neuroprotective effects of TH on brain injury and motor outcomes in the postnatal-day 10 (P10) hypoxic-ischemic (HI) rat...
October 20, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29047256/analysis-of-genes-with-alternatively-spliced-transcripts-in-the-leaf-root-panicle-and-seed-of-rice-using-a-long-oligomer-microarray-and-rna-seq
#16
Songhwa Chae, Joung Sug Kim, Kyong Mi Jun, Sang-Bok Lee, Myung Soon Kim, Baek Hie Nahm, Yeon-Ki Kim
Pre-mRNA splicing further increases protein diversity acquired through evolution. The underlying driving forces for this phenomenon are unknown, especially in terms of gene expression. A rice alternatively spliced transcript detection microarray (ASDM) and RNA sequencing (RNA-Seq) were applied to differentiate the transcriptome of 4 representative organs of Oryza sativa L. cv. Ilmi: leaves, roots, 1-cm-stage panicles and young seeds at 21 days after pollination. Comparison of data obtained by microarray and RNA-Seq showed a bell-shaped distribution and a co-lineation for highly expressed genes...
October 2017: Molecules and Cells
https://www.readbyqxmd.com/read/29020835/quantifying-benefits-of-using-health-information-exchange-to-support-public-health-sti-reporting-and-treatment-in-western-new-york
#17
Saira N Haque, Heather Territo, Robert Bailey, Barbara Massoudi, Ross Loomis, Gale Burstein
OBJECTIVE: To calculate average savings of using health information exchange (HIE) for demographic and treatment requests for chlamydia and gonorrhoea in Western New York, specifically the Erie County Department of Health and its catchment area. METHOD: We conducted a mixed-method case study. Qualitative methods included interviews, document review, and workflow mapping, which were used as the inputs to identify time savings. Case rates, time savings, and salary averages were used to calculate average savings...
January 1, 2017: HIM Journal
https://www.readbyqxmd.com/read/29017421/access-to-medical-records-impact-on-community-pharmacist-delivered-medication-therapy-management-a-pilot-from-the-medication-safety-research-network-of-indiana-rx-safenet
#18
Stephanie A Gernant, Alan J Zillich, Margie E Snyder
BACKGROUND: Medication therapy management (MTM) may be optimized if pharmacists engaged in health information exchange (HIE) by reviewing unedited medical records. METHODS: In this nonblinded, randomized, controlled pilot, pharmacists delivered a part of MTM, comprehensive medication reviews (CMRs), to adult patients in a practice-based research network (PBRN). Intervention community pharmacists solicited the last 6 months of patients' primary care provider-held, unedited medical records...
January 1, 2017: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29016557/future-perspectives-of-cell-therapy-for-neonatal-hypoxic-ischemic-encephalopathy
#19
REVIEW
Makoto Nabetani, Haruo Shintaku, Takashi Hamazaki
Neonatal ischemic brain injury causes permanent motor-deficit cerebral palsy. Hypoxic-ischemic encephalopathy (HIE) is a very serious condition that can result in death and disability. In 1997, we reported that irreversible neuronal cell damage is induced by the elevation of intracellular Ca ion concentration that has occurred in sequence after excess accumulation of the excitatory neurotransmitter glutamate during ischemia. We also reported that hypothermia was effective in treating ischemic brain damage in rats by suppressing energy loss and raising intracellular Ca ion concentration...
October 10, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28994852/h%C3%A3-gdos-insulin%C3%A2-%C3%A2-euglykemiterapi-vid-sv%C3%A3-r-%C3%A2-toxisk-myokard%C3%A2-depression-ett-viktigt-tillskott-i-behandlingsarsenalen
#20
Erik Lindeman, Lovisa Baer Eriksson, Martin Thorsson, Johanna Nordmark Grass
High dose insulin euglycemia therapy - an important addition to the treatment arsenal in severe toxic myocardial depression Fifty-nine patients who developed hemodynamic symptoms necessitating treatment with vasopressors or inotropes after poisoning with calcium channel blockers (CCB) and beta blockers (BB) between January 2010 and August 2016 were identified by a search of the Poisons Information Centre database. In-hospital circulatory arrest occurred in 16/59 (27 %) and the mortality rate was 7/59 (12 %)...
October 9, 2017: Läkartidningen
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