Heini Sánez Tähtisalo, Sanni Ruotsalainen, Nina Mars, Kimmo Porthan, Lasse Oikarinen, Juha Virolainen, Frej Fyhrquist, Samuli Ripatti, Kimmo K Kontula, Timo P Hiltunen
Polygenic risk scores (PRSs) for essential hypertension, calculated from > 900 genomic loci, were recently found to explain a significant fraction of hypertension heritability and complications. To investigate whether variation of hypertension PRS also captures variation of antihypertensive drug responsiveness, we calculated two different PRSs for both systolic and diastolic blood pressure: one based on the top 793 independent hypertension-associated single nucleotide polymorphisms and another based on over 1 million genome-wide variants...
July 20, 2020: Scientific Reports