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https://read.qxmd.com/read/37899885/microarray-expression-profile-and-bioinformatic-analysis-of-circular-rna-in-human-arteriosclerosis-obliterans
#1
JOURNAL ARTICLE
Yu Zhou, Huoying Cai, Lin Huang, Mingshan Wang, Ruiming Liu, Siwen Wang, Yuansen Qin, Chen Yao, Zuojun Hu
BACKGROUND: Arteriosclerosis obliterans (ASO) is the leading cause of nontraumatic lower-extremity amputations. Multiple researches have suggested that circular RNAs (circRNAs) played vital regulatory functions in cancer and cardiovascular disease. Nevertheless, the underlying effect and pathological mechanism of circRNAs in the formation and progression of ASO are still indistinct. METHODS AND RESULTS: This study used microarray analysis to investigate the expression portrait of circRNAs in normal lower extremity arteries and ASO arteries...
2023: Pharmacogenomics and Personalized Medicine
https://read.qxmd.com/read/32686723/human-essential-hypertension-no-significant-association-of-polygenic-risk-scores-with-antihypertensive-drug-responses
#2
JOURNAL ARTICLE
Heini Sánez Tähtisalo, Sanni Ruotsalainen, Nina Mars, Kimmo Porthan, Lasse Oikarinen, Juha Virolainen, Frej Fyhrquist, Samuli Ripatti, Kimmo K Kontula, Timo P Hiltunen
Polygenic risk scores (PRSs) for essential hypertension, calculated from > 900 genomic loci, were recently found to explain a significant fraction of hypertension heritability and complications. To investigate whether variation of hypertension PRS also captures variation of antihypertensive drug responsiveness, we calculated two different PRSs for both systolic and diastolic blood pressure: one based on the top 793 independent hypertension-associated single nucleotide polymorphisms and another based on over 1 million genome-wide variants...
July 20, 2020: Scientific Reports
https://read.qxmd.com/read/26083242/genome-wide-association-study-identifies-novel-pharmacogenomic-loci-for-therapeutic-response-to-montelukast-in-asthma
#3
JOURNAL ARTICLE
Amber Dahlin, Augusto Litonjua, John J Lima, Mayumi Tamari, Michiaki Kubo, Charles G Irvin, Stephen P Peters, Kelan G Tantisira
BACKGROUND: Genome-wide association study (GWAS) is a powerful tool to identify novel pharmacogenetic single nucleotide polymorphisms (SNPs). Leukotriene receptor antagonists (LTRAs) are a major class of asthma medications, and genetic factors contribute to variable responses to these drugs. We used GWAS to identify novel SNPs associated with the response to the LTRA, montelukast, in asthmatics. METHODS: Using genome-wide genotype and phenotypic data available from American Lung Association - Asthma Clinical Research Center (ALA-ACRC) cohorts, we evaluated 8-week change in FEV1 related to montelukast administration in a discovery population of 133 asthmatics...
2015: PloS One
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