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https://www.readbyqxmd.com/read/29341860/risk-management-of-free-radicals-involved-in-air-travel-syndromes-by-antioxidants
#1
Jeum-Nam Kim, Byung-Mu Lee
Frequent air travelers and airplane pilots may develop various types of illnesses. The environmental risk factors associated with air travel syndromes (ATS) or air travel-related adverse health outcomes raised concerns and need to be assessed in the context of risk management and public health. Accordingly, the aim of the present review was to determine ATS, risk factors, and mechanisms underlying ATS using scientific data and information obtained from Medline, Toxline, and regulatory agencies. Additional information was also extracted from websites of organizations, such as the International Air Transport Association (IATA), International Association for Medical Assistance to Travelers (IAMAT), and International Civil Aviation Organization (ICAO)...
January 17, 2018: Journal of Toxicology and Environmental Health. Part B, Critical Reviews
https://www.readbyqxmd.com/read/29334653/depletion-study-withdrawal-period-calculation-and-bioaccumulation-of-sulfamethazine-in-tilapia-oreochromis-niloticus-treated-with-medicated-feed
#2
Kátia S D Nunes, José H Vallim, Márcia R Assalin, Sonia C N Queiroz, Lourival C Paraíba, Claudio M Jonsson, Felix G R Reyes
The residue depletion of sulfamethazine (SMZ) was evaluated in tilapia (Oreochromis niloticus) after 11 days of administration of medicated feed containing SMZ, at the dose of 422 mg/kg body weight (bw). The determination of SMZ in feed and tilapia fillet was carried out using the QuEChERS approach for sample preparation, and high performance liquid chromatography with diode array detector (HPLC-DAD) and ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QToF-MS) for quantitation, respectively...
January 9, 2018: Chemosphere
https://www.readbyqxmd.com/read/29332776/compliance-with-a-national-standard-by-norwegian-helicopter-emergency-physicians
#3
Lars Petter Bjørnsen, Andrea Marie Solheim, Oddvar Uleberg, Eirik Skogvoll
OBJECTIVE: The "National Standard Requirements for Helicopter Emergency Medicine Services Physicians" gives recommendations on medical requirements for flight physicians. This study describes the level of formal competence, experience, and guideline compliance of Norwegian helicopter emergency medical service (HEMS) physicians. METHODS: In May 2013, all HEMS physicians with full-time engagement at Norwegian HEMS bases were invited to participate in a cross-sectional survey using a structured, Web-based questionnaire...
January 2018: Air Medical Journal
https://www.readbyqxmd.com/read/29332773/does-medical-staffing-influence-perceived-safety-an-international-survey-on-medical-crew-models-in-helicopter-emergency-medical-services
#4
Kristen Rasmussen, Jo Røislien, Stephen J M Sollid
OBJECTIVE: The competence, composition, and number of crewmembers have generally been considered to influence the degree of patient care and safety in helicopter emergency medical services (HEMS), but evidence to support the advantages of one crew concept over another is ambiguous; additionally, the benefit of physicians as crewmembers is still highly debated. METHODS: To compare perceived safety in different medical crew models, we surveyed international HEMS medical directors regarding the types of crew compositions their system currently used and their supportive rationales and to evaluate patient and flight safety within their services...
January 2018: Air Medical Journal
https://www.readbyqxmd.com/read/29332730/biomechanical-factors-associated-with-running-economy-and-performance-of-elite-kenyan-distance-runners-a-systematic-review
#5
REVIEW
Nassib Tawa, Quinette Louw
BACKGROUND: Running economy (RE) is a determinant of performance in endurance sports and is a complex multi-factorial measure which reflects the combined functioning of bio-mechanical, neuro-muscular, metabolic and cardio-respiratory factors some of which are hereditary or adapt to coaching. Kenyan distance runners have dominated major global events with their unmatched performance for decades and this phenomenon has prompted several investigations aimed at establishing possible factors associated with their performance...
January 2018: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/29308793/extensive-first-principles-molecular-dynamics-study-on-li-encapsulation-into-c60-and-its-experimental-confirmation
#6
K Ohno, A Manjanath, Y Kawazoe, R Hatakeyama, F Misaizu, E Kwon, H Fukumura, H Ogasawara, Y Yamada, C Zhang, N Sumi, T Kamigaki, K Kawachi, K Yokoo, S Ono, Y Kasama
The aim of increasing the production ratio of endohedral C60 by impinging foreign atoms against C60 is a crucial matter of the science and technology employed towards industrialization of these functional building block materials. Among these endohedral fullerenes, Li+@C60 exhibits a wide variety of physical and chemical phenomena and has the potential to be applicable in areas spanning the medical field to photovoltaics. However, currently, Li+@C60 can be experimentally produced with only ∼1% ratio using the plasma shower method with a 30 eV kinetic energy provided to the impinging Li+ ion...
January 8, 2018: Nanoscale
https://www.readbyqxmd.com/read/29307641/is-there-a-doctor-onboard-the-ethical-conundrum-of-a-specialist-asked-to-provide-in-flight-medical-assistance
#7
Sunil H Adwani, Preeti Jhorar, Jane M Grant-Kels
No abstract text is available yet for this article.
January 4, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29306937/the-effects-of-stress-and-meditation-on-the-immune-system-human-microbiota-and-epigenetics
#8
Ayman Mukerji Househam, Christine Tara Peterson, Paul J Mills, Deepak Chopra
Context • Globally, more than 25% of individuals are affected by anxiety and depression disorders. Meditation is gaining popularity in clinical settings and its treatment efficacy is being studied for a wide array of psychological and physiological ailments. An exploration of stress physiology is an essential precursor to delineation of the mechanisms underlying the beneficial effects of meditation practices. Objective • The review outlines a model of interconnected physiological processes that might support the continued inclusion and expansion of meditation in the treatment of diverse medical conditions and to investigate the role that gut microbiota may play in realizing well-being through meditation...
October 2017: Advances in Mind-body Medicine
https://www.readbyqxmd.com/read/29305644/mal-de-debarquement-syndrome-a-survey-on-subtypes-misdiagnoses-onset-and-associated-psychological-features
#9
V Mucci, J M Canceri, R Brown, M Dai, S Yakushin, S Watson, A Van Ombergen, V Topsakal, P H Van de Heyning, F L Wuyts, C J Browne
INTRODUCTION: Mal de Debarquement Syndrome (MdDS) is a neurological condition typically characterized by a sensation of motion, that persists longer than a month following exposure to passive motion (e.g., cruise, flight, etc.). The most common form of MdDS is motion triggered (MT). However, recently it has been acknowledged that some patients develop typical MdDS symptoms without an apparent motion trigger. These cases are identified here as spontaneous or other onset (SO) MdDS. This study aimed to address similarities and differences between the MdDS subtypes...
January 5, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29301034/impact-of-%C3%AE-glucuronidase-mediated-hydrolysis-on-haldol%C3%A2-urinalysis
#10
Oneka T Cummings, Erin C Strickland, Jeffrey R Enders, Gregory McIntire
Reports have suggested that patients with mental health disorders including major depressive disorder and schizophrenia have dramatically low adherence levels to prescribed medications. Patients on haloperidol (Haldol®) therapy, regardless of their disease, were found to have higher adherence levels-though still strikingly low. This work shows that high levels of the glucuronidated form of haloperidol are present in patient urine samples. Time-of-Flight (TOF) mass spectrometry experiments are consistent with both the presence of haloperidol glucuronide and that hydrolysis of haloperidol patient urine samples leads to significantly increased concentrations of free haloperidol...
December 28, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/29299505/utility-of-adjunctive-procedures-with-balloon-dilation-of-the-eustachian-tube
#11
Yehia Ashry, Kosuke Kawai, Dennis Poe
Objective: To assess the role and effect of concomitant adjunctive procedures when combined with balloon dilation of the Eustachian tube (BDET), including a new technique for treating obstructive disease within the bony Eustachian tube (ET). Study Design: Retrospective case series. Setting: Tertiary medical center. Subjects: Adults with persistent (≥2 years): 1) OME or non-fixed TM retraction AND type B or C tympanogram OR 2) Consistent symptoms of barochallenge with flights or diving, all despite medical treatment for ≥6 weeks...
December 2017: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/29228515/aging-and-cardiometabolic-risk-in-european-hems-pilots-an-assessment-of-occupational-old-age-limits-as-a-regulatory-risk-management-strategy
#12
Hans Bauer, Dennis Nowak, Britta Herbig
Old-age limits are imposed in some occupations in an effort to ensure public safety. In aviation, the "Age 60 Rule" limits permissible flight operations conducted by pilots aged 60 and over. Using a retrospective cohort design, we assessed this rule's validity by comparing age-related change rates of cardiometabolic incapacitation risk markers in European helicopter emergency medical service (HEMS) pilots near age 60 with those in younger pilots. Specifically, individual clinical, laboratory, and electrocardiogram (ECG)-based risk markers and an overall cardiovascular event risk score were determined from aeromedical examination records of 66 German, Austrian, Polish, and Czech HEMS pilots (average follow-up 8...
December 11, 2017: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/29227188/clinical-strains-of-chryseobacterium-and-elizabethkingia-spp-isolated-from-pediatric-patients-in-a-university-hospital-performance-of-maldi-tof-ms-based-identification-antimicrobial-susceptibilities-and-baseline-patient-characteristics
#13
Hasan Cenk Mirza, Özlem Tuncer, Serpil Ölmez, Burçin Şener, Gökçen Dilşa Tuğcu, Uğur Özçelik, Nafia Canan Gürsoy, Barış Otlu, Ayşe Büyükçam, Ateş Kara, Banu Sancak
Our objective was to evaluate the performance of matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) for identification of the Chryseobacterium and Elizabethkingia spp. isolated from pediatric patients at Hacettepe University Hospital using 16S rRNA gene sequencing as the gold standard and to determine the antimicrobial susceptibility patterns of the isolates and baseline characteristics of patients. All stored Chryseobacterium and Elizabethkingia spp. isolated from various clinical specimens (sputum, blood, and urine) of pediatric patients at Hacettepe University Hospital between 2012 and 2016 were included in this study...
December 11, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29224023/negative-symptoms-and-avoidance-of-social-interaction-a-study-of-non-verbal-behaviour
#14
Elizabeth Worswick, Sara Dimic, Christiane Wildgrube, Stefan Priebe
BACKGROUND: Non-verbal behaviour is fundamental to social interaction. Patients with schizophrenia display an expressivity deficit of non-verbal behaviour, exhibiting behaviour that differs from both healthy subjects and patients with different psychiatric diagnoses. The present study aimed to explore the association between non-verbal behaviour and symptom domains, overcoming methodological shortcomings of previous studies. SAMPLING AND METHODS: Standardised interviews with 63 outpatients diagnosed with schizophrenia were videotaped...
December 9, 2017: Psychopathology
https://www.readbyqxmd.com/read/29216684/the-impact-of-corynebacterium-glucuronolyticum-on-semen-parameters-a-prospective-pre-post-treatment-study
#15
T Meštrović, B Bedenić, J Wilson, S Ljubin-Sternak, M Sviben, M Neuberg, R Ribić, G Kozina, Z Profozić
Corynebacterium glucuronolyticum (C. glucuronolyticum) is a rare isolate that is only recently being acknowledged as a potential urogenital pathogen. The bibliographical references on this bacterial species are scarce, and its influence on all semen parameters was hitherto unknown - therefore, the aim of this study was to evaluate its effects on a range of sperm quality parameters. A prospective approach to compare semen parameters before and after treatment was used in this study. C. glucuronolyticum in semen specimens was identified using analytical profile index biotyping system (API Coryne) and additionally confirmed by matrix-assisted laser desorption/ionization time-of-flight mass-spectrometry (MALDI-TOF MS), with the determination of antimicrobial susceptibility by Kirby-Bauer method...
December 7, 2017: Andrology
https://www.readbyqxmd.com/read/29214236/characterization-of-byproducts-from-chemical-syntheses-of-oligonucleotides-containing-1-methyladenine-and-3-methylcytosine
#16
Qi Tang, Ang Cai, Ke Bian, Fangyi Chen, James C Delaney, Sravani Adusumalli, Alvin C Bach, Fatemeh Akhlaghi, Bongsup P Cho, Deyu Li
Oligonucleotides serve as important tools for biological, chemical, and medical research. The preparation of oligonucleotides through automated solid-phase synthesis is well-established. However, identification of byproducts generated from DNA synthesis, especially from oligonucleotides containing site-specific modifications, is sometimes challenging. Typical high-performance liquid chromatography (HPLC), mass spectrometry (MS), and gel electrophoresis methods alone are not sufficient for characterizing unexpected byproducts, especially for those having identical or very similar molecular weight (MW) to the products...
November 30, 2017: ACS Omega
https://www.readbyqxmd.com/read/29205628/clinical-neuroimaging-using-7-t-mri-challenges-and-prospects
#17
REVIEW
Maria Isabel Vargas, Pascal Martelli, Lijing Xin, Ozlem Ipek, Frederic Grouiller, Francesca Pittau, Robert Trampel, Rolf Gruetter, Serge Vulliemoz, Francois Lazeyras
The aim of this article is to illustrate the principal challenges, from the medical and technical point of view, associated with the use of ultrahigh field (UHF) scanners in the clinical setting and to present available solutions to circumvent these limitations. We would like to show the differences between UHF scanners and those used routinely in clinical practice, the principal advantages, and disadvantages, the different UHFs that are ready be applied to routine clinical practice such as susceptibility-weighted imaging, fluid-attenuated inversion recovery, 3-dimensional time of flight, magnetization-prepared rapid acquisition gradient echo, magnetization-prepared 2 rapid acquisition gradient echo, and diffusion-weighted imaging, the technical principles of these sequences, and the particularities of advanced techniques such as diffusion tensor imaging, spectroscopy, and functional imaging at 7TMR...
January 2018: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/29202769/impact-of-systolic-blood-pressure-limits-on-the-diagnostic-value-of-triage-algorithms
#18
Tobias Neidel, Nicolas Salvador, Axel R Heller
BACKGROUND: Major incidents are characterized by a lack of resources compared to an overwhelming number of casualties, requiring a prioritization of medical treatment. Triage algorithms are an essential tool for prioritizing the urgency of treatment for patients, but the evidence to support one over another is very limited. We determined the influence of blood pressure limits on the diagnostic value of triage algorithms, considering if pulse should be palpated centrally or peripherally...
December 4, 2017: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/29195773/cognitive-deficits-in-bipolar-disorders-implications-for-emotion
#19
REVIEW
Isabela M M Lima, Andrew D Peckham, Sheri L Johnson
Prominent cognitive deficits have been documented in bipolar disorder, and multiple studies suggest that these deficits can be observed among non-affected first-degree relatives of those with bipolar disorder. Although there is variability in the degree of cognitive deficits, these deficits are robustly relevant for functional outcomes. A separate literature documents clear difficulties in emotionality, emotion regulation, and emotion-relevant impulsivity within bipolar disorder, and demonstrates that these emotion-relevant variables are also central to outcome...
November 21, 2017: Clinical Psychology Review
https://www.readbyqxmd.com/read/29194963/simultaneous-detection-of-protein-and-mrna-in-jurkat-and-kg-1a-cells-by-mass-cytometry
#20
Anastasia Mavropoulos, Bedilu Allo, Mingxiao He, Emily Park, Daniel Majonis, Olga Ornatsky
Mass cytometry uniquely enables high-dimensional single-cell analysis of complex populations. This recently developed technology is based on inductively coupled time-of-flight mass spectrometry for multiplex proteomic analysis of more than 40 markers per cell. The ability to characterize the transcriptome is critical for the understanding of disease pathophysiology, medical diagnostics, and drug discovery. Current techniques allowing the in situ detection of transcripts in single cells are limited to a small number of simultaneous targets and are generally tedious and labor-intensive...
November 30, 2017: Cytometry. Part A: the Journal of the International Society for Analytical Cytology
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