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https://www.readbyqxmd.com/read/28087424/clinical-applications-of-maldi-imaging-technologies-in-cancer-and-neurodegenerative-diseases
#1
REVIEW
Yasemin Ucal, Zeynep Aslıhan Durer, Hakan Atak, Elif Kadioglu, Betul Sahin, Abdurrahman Coskun, Ahmet Tarık Baykal, Aysel Ozpinar
Matrix-assisted laser desorption/ionization (MALDI) time-of-flight (TOF) imaging mass spectrometry (IMS) enables localization of analytes of interest along with histology. More specifically, MALDI-IMS identifies the distributions of proteins, peptides, small molecules, lipids, and drugs and their metabolites in tissues, with high spatial resolution. This unique capacity to directly analyze tissue samples without the need for lengthy sample preparation reduces technical variability and renders MALDI-IMS ideal for the identification of potential diagnostic and prognostic biomarkers and disease gradation...
January 10, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28081144/digital-health-tracking-physiomes-and-activity-using-wearable-biosensors-reveals-useful-health-related-information
#2
Xiao Li, Jessilyn Dunn, Denis Salins, Gao Zhou, Wenyu Zhou, Sophia Miryam Schüssler-Fiorenza Rose, Dalia Perelman, Elizabeth Colbert, Ryan Runge, Shannon Rego, Ria Sonecha, Somalee Datta, Tracey McLaughlin, Michael P Snyder
A new wave of portable biosensors allows frequent measurement of health-related physiology. We investigated the use of these devices to monitor human physiological changes during various activities and their role in managing health and diagnosing and analyzing disease. By recording over 250,000 daily measurements for up to 43 individuals, we found personalized circadian differences in physiological parameters, replicating previous physiological findings. Interestingly, we found striking changes in particular environments, such as airline flights (decreased peripheral capillary oxygen saturation [SpO2] and increased radiation exposure)...
January 2017: PLoS Biology
https://www.readbyqxmd.com/read/28069916/flight-lieutenant-peach-s-observations-on-burning-feet-syndrome-in-far-eastern-prisoners-of-war-1942-45
#3
N T Roocroft, E Mayhew, M Parkes, W A Frankland, G V Gill, D Bouhassira, A S C Rice
INTRODUCTION: 'Burning Feet Syndrome' affected up to one third of Far Eastern Prisoners of War in World War 2. Recently discovered medical records, produced by RAF Medical Officer Nowell Peach whilst in captivity, are the first to detail neurological examinations of patients with this condition. METHODS: The 54 sets of case notes produced at the time were analysed using modern diagnostic criteria to determine if the syndrome can be retrospectively classed as neuropathic pain...
November 15, 2016: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/28068211/cost-analysis-of-measles-in-refugees-arriving-at-los-angeles-international-airport-from-malaysia
#4
Margaret S Coleman, Heather M Burke, Bethany L Welstead, Tarissa Mitchell, Eboni M Taylor, Dmitry Shapovalov, Brian A Maskery, Heesoo Joo, Michelle Weinberg
Background On August 24, 2011, 31 U.S.-bound refugees from Kuala Lumpur, Malaysia (KL) arrived in Los Angeles. One of them was diagnosed with measles post-arrival. He exposed others during a flight, and persons in the community while disembarking and seeking medical care. As a result, nine cases of measles were identified. Methods We estimated costs of response to this outbreak and conducted a comparative cost analysis examining what might have happened had all U.S.-bound refugees been vaccinated before leaving Malaysia...
January 9, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28068065/sustained-nitric-oxide-release-from-a-tertiary-s-nitrosothiol-based-polyphosphazene-coating
#5
Alec Lutzke, Jesus B Tapia, Megan J Neufeld, Melissa M Reynolds
Nitric oxide (NO) occurs naturally in mammalian biochemistry as a critical signaling molecule and exhibits antithrombotic, antibacterial, and wound-healing properties. NO-forming biodegradable polymers have been utilized in the development of antithrombotic or antibacterial materials for biointerfacial applications, including tissue engineering and the fabrication of erodible coatings for medical devices such as stents. Use of such NO-forming polymers has frequently been constrained by short-term release or limited NO storage capacity and has led to the pursuit of new materials with improved NO release function...
January 9, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28061924/asymptomatic-wolff-parkinson-white-pattern-ecg-in-usaf-aviators
#6
Eddie D Davenport, Karen A N Rupp, Edwin Palileo, Jared Haynes
INTRODUCTION: Wolff-Parkinson-White (WPW) pattern is occasionally found in asymptomatic aviators during routine ECGs. Aeromedical concerns regarding WPW pattern include risk of dysrhythmia or sudden cardiac death (SCD), thus affecting the safety of flight. The purpose of this study was to determine the prevalence and outcomes of aviators with asymptomatic WPW pattern and assess for risk factors that contribute to progression to dysrhythmia or symptoms. METHODS: The U...
January 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28061920/the-u-s-experience-with-waivers-for-insulin-treated-pilots
#7
William D Mills, Charles A DeJohn, Mustafa Alaziz
INTRODUCTION: This study explores the U.S. experience with waivers for insulin treatment for third-class medical certificates. From 1997 through 2014, the Federal Aviation Administration (FAA) approved an estimated 1500 waivers for insulin-treated diabetes with a total of 450 active waivers as of December 31, 2014. These pilots were involved in 25 accidents, but none were attributed to medical issues. METHODS: Data for the insulin waiver group and control group were obtained from the FAA's aeromedical certification system and matching accident data from the NTSB database...
January 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28061918/clinical-experience-and-learning-style-of-flight-nurse-and-aeromedical-evacuation-technician-students
#8
Marla J De Jong, Susan F Dukes, Karey M Dufour, Darcy L Mortimer
BACKGROUND: The clinical experience and preferred learning style of U.S. Air Force flight nurses and aeromedical evacuation technicians are unknown. METHODS: Using a cross-sectional survey design, we gathered data regarding the clinical experience, level of comfort providing clinical care, and preferred learning style of 77 active duty (AD), Air Force Reserve (AFR), and Air National Guard (ANG) nurses enrolled in the U.S. Air Force School of Aerospace Medicine Flight Nurse course, and 121 AD, AFR, and ANG medical technicians enrolled in the Aeromedical Evacuation Technician course...
January 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28061915/prevalence-predictors-and-prevention-of-motion-sickness-in-zero-g-parabolic-flights
#9
John F Golding, Aurore C Paillard, Hervé Normand, Stéphane Besnard, Pierre Denise
INTRODUCTION: Zero-G parabolic flight reproduces the weightlessness of space for short periods. However, motion sickness may affect some fliers. The aim was to assess the extent of this problem and to find possible predictors and modifying factors. METHODS: Airbus zero-G flights consist of 31 parabolas performed in blocks. Each parabola consisted of 20 s of 0 g sandwiched by 20 s of hypergravity of 1.5-1.8 g. The survey covered N = 246 person-flights (193 men, 53 women), ages (M ± SD) 36...
January 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28059581/hot-and-cold-drugs-national-park-service-medication-stability-at-the-extremes-of-temperature
#10
Patil Armenian, Danielle Campagne, Geoff Stroh, Crystal Ives Tallman, William Z D Zeng, Thomas Lin, Roy R Gerona
STUDY OBJECTIVE: National Park Service (NPS) Parkmedics provide medical care in austere environments. The objective of this study was to evaluate the stability of specific medications used by Parkmedics at extremes of temperatures likely to be faced in the field. METHODS: This is a bench research study conducted in the laboratory setting over a 4-week period. Parenteral medications were separated into 4 temperature exposure groups: A) 45°C (hot); B) -20°C (cold); C) hot then cold temperatures alternating weekly; and D) cold then hot temperatures alternating weekly...
January 6, 2017: Prehospital Emergency Care
https://www.readbyqxmd.com/read/28056838/first-case-report-of-myopericarditis-linked-to-campylobacter-coli-enterocolitis
#11
Cameron R M Moffatt, Soniah B Moloi, Karina J Kennedy
BACKGROUND: Campylobacter spp. are a common cause of mostly self-limiting enterocolitis. Although rare, pericarditis and myopericarditis have been increasingly documented as complications following campylobacteriosis. Such cases have occurred predominantly in younger males, and involved a single causative species, namely Campylobacter jejuni. We report the first case of myopericarditis following Campylobacter coli enterocolitis, with illness occurring in an immunocompetent middle-aged female...
January 5, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28030500/analysis-of-aeromedical-retrieval-coverage-using-elliptical-isochrones-an-evaluation-of-helicopter-fleet-size-configurations-in-scotland
#12
Naomi Dodds, Phillip Emerson, Stephanie Phillips, David R Green, Jan O Jansen
BACKGROUND: Trauma systems in remote and rural regions often rely on helicopter emergency medical services to facilitate access to definitive care. The siting of such resources is key, but often relies on simplistic modelling of coverage, using circular isochrones. Scotland is in the process of implementing a national trauma network, and there have been calls for an expansion of aeromedical retrieval capacity. The aim of this study was to analyse population and area coverage of the current retrieval service configuration, with three aircraft, and a configuration with an additional helicopter, in the North East of Scotland, using a novel methodology...
December 23, 2016: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28027558/cognitive-evoked-potentials-p300-after-radiation-exposure
#13
K M Loganovsky, K V Kuts
OBJECTIVE: The study was aimed at evaluating features of brain information processes and cognitive functioning in the remote period after irradiation due to the Chornobyl accident by using cognitive evoked potentials P300. MATERIALS AND METHODS: The study included 128 people, 112 male Chornobyl clean up workers in 1986-1987 with the records of radiation doses available in Clinical and Epidemiological Registry (CER) of State Institution «National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine» (NRCRM) (study group) and 16 unexposed persons due to the Chornobyl disaster (control group)...
December 2016: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
https://www.readbyqxmd.com/read/28027163/the-business-of-health-physics-jobs-in-a-changing-market
#14
Matthew P Moeller
The health physics profession was born abruptly when once rare and precious radioactive materials became commonplace. The technological advancements that triggered an industrial complex and ended World War II demanded radiation safety on an unprecedented scale. Until then, protective measures against radiation were largely absent in laboratories. Over the subsequent decades, health physicists began protecting people and the environment in a wide range of settings including medical, research, and industrial...
February 2017: Health Physics
https://www.readbyqxmd.com/read/27999095/a-case-report-of-fatal-desmethyl-carbodenafil-toxicity
#15
Erica L Bakota, Anna T Kelly, Jeffrey P Walterscheid, Darshan R Phatak
We present the case report of a 34-year-old Hispanic male who was found unresponsive in the carport of his residence. Surveillance video footage from a security camera showed that he collapsed as he was walking to his vehicle. The decedent had no medical history and no history of illicit drug use. Initial toxicology testing revealed no alcohol or illicit drugs. Autopsy findings indicated a need for additional toxicological analysis due to a lack of trauma and the paucity of pathophysiologically significant natural disease...
December 19, 2016: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/27974043/airplane-pilot-mental-health-and-suicidal-thoughts-a-cross-sectional-descriptive-study-via-anonymous-web-based-survey
#16
Alexander C Wu, Deborah Donnelly-McLay, Marc G Weisskopf, Eileen McNeely, Theresa S Betancourt, Joseph G Allen
BACKGROUND: The Germanwings Flight 9525 crash has brought the sensitive subject of airline pilot mental health to the forefront in aviation. Globally, 350 million people suffer from depression-a common mental disorder. This study provides further information on this important topic regarding mental health especially among female airline pilots. This is the first study to describe airline pilot mental health-with a focus on depression and suicidal thoughts-outside of the information derived from aircraft accident investigations, regulated health examinations, or identifiable self-reports, which are records protected by civil aviation authorities and airline companies...
December 15, 2016: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/27957598/clinical-and-microbiological-features-of-actinotignum-bacteremia-a-retrospective-observational-study-of-57-cases
#17
H Pedersen, E Senneby, M Rasmussen
The purpose of this study was to investigate the incidence, clinical presentation, and prognosis of Actinotignum bacteremia in southern Sweden. Actinotignum isolates in blood cultures were identified retrospectively between 1st January 2012 and 31st March 2016 through searches in the clinical microbiology laboratory database. The population covered by this laboratory is approximately 1.3 million. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) was used for species determination...
December 12, 2016: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/27943430/tissue-specific-metabolite-profiling-of-benzylisoquinoline-alkaloids-in-the-root-of-macleaya-cordata-by-combining-laser-microdissection-with-ultra-high-performance-liquid-chromatography-tandem-mass-spectrometry
#18
Zi Zuo, Yajie Zheng, Zhitao Liang, Yisong Liu, Qi Tang, Xiubin Liu, Zhongzhen Zhao, Jianguo Zeng
RATIONALE: Tissue-specific metabolite profiling helps finding trace alkaloids masked during the organ analysis, which contributes to understand the alkaloid biosynthetic pathways in vivo and evaluate the quality of medical plant by morphology. As Macleaya cordata contains the diverse types of benzylisoquinoline alkaloids (BIAs), the alkaloid metabolite profiling was carried out on the various tissues of root. METHODS: The laser microdissection with fluorescence detection was used to recognize and dissect different tissues from the root of M...
December 11, 2016: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/27941573/in-flight-injuries-involving-children-on-commercial-airline-flights
#19
Paulo M Alves, Neil Nerwich, Alexandre T Rotta
BACKGROUND: More than 3 billion passengers are transported every year on commercial airline flights worldwide, many of whom are children. The incidence of in-flight medical events (IFMEs) affecting children is largely unknown. This study seeks to characterize pediatric IFMEs, with particular focus on in-flight injuries (IFIs). METHODS: We reviewed the records of all IFMEs from January 2009 to January 2014 involving children treated in consultation with a ground-based medical support center providing medical support to commercial airlines...
December 9, 2016: Pediatric Emergency Care
https://www.readbyqxmd.com/read/27924713/acetylcholinesterase-and-neuropathy-target-esterase-activities-in-11-cases-of-symptomatic-flight-crew-members-after-fume-events
#20
Astrid R R Heutelbeck, Catherine Bornemann, Martina Lange, Anke Seeckts, Michael M Müller
In modern aviation, so-called fume events such as exposure to an unknown mixture of chemicals introduced into the aircraft cabin with bleed air drawn off at the engines may occur. Human exposure may result in (neuro)toxic symptoms described as so-called "aerotoxic syndrome." Currently, among other agents organophosphates (OP) are regarded as a likely cause of the observed adverse effects. After fume events 11 flight crew members (9 female/2 male; ages 23-58 yr) were admitted for a medical examination within 5 d post exposure...
2016: Journal of Toxicology and Environmental Health. Part A
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